-- dump date 20140619_151854 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1205674000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1205674000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674000003 Walker A motif; other site 1205674000004 ATP binding site [chemical binding]; other site 1205674000005 Walker B motif; other site 1205674000006 arginine finger; other site 1205674000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1205674000008 DnaA box-binding interface [nucleotide binding]; other site 1205674000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1205674000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1205674000011 putative DNA binding surface [nucleotide binding]; other site 1205674000012 dimer interface [polypeptide binding]; other site 1205674000013 beta-clamp/clamp loader binding surface; other site 1205674000014 beta-clamp/translesion DNA polymerase binding surface; other site 1205674000015 recF protein; Region: recf; TIGR00611 1205674000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1205674000017 Walker A/P-loop; other site 1205674000018 ATP binding site [chemical binding]; other site 1205674000019 Q-loop/lid; other site 1205674000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674000021 ABC transporter signature motif; other site 1205674000022 Walker B; other site 1205674000023 D-loop; other site 1205674000024 H-loop/switch region; other site 1205674000025 hypothetical protein; Provisional; Region: PRK03195 1205674000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1205674000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674000028 Mg2+ binding site [ion binding]; other site 1205674000029 G-X-G motif; other site 1205674000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1205674000031 anchoring element; other site 1205674000032 dimer interface [polypeptide binding]; other site 1205674000033 ATP binding site [chemical binding]; other site 1205674000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1205674000035 active site 1205674000036 putative metal-binding site [ion binding]; other site 1205674000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1205674000038 DNA gyrase subunit A; Validated; Region: PRK05560 1205674000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1205674000040 CAP-like domain; other site 1205674000041 active site 1205674000042 primary dimer interface [polypeptide binding]; other site 1205674000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205674000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205674000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205674000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205674000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205674000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205674000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1205674000050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674000051 salt bridge; other site 1205674000052 non-specific DNA binding site [nucleotide binding]; other site 1205674000053 sequence-specific DNA binding site [nucleotide binding]; other site 1205674000054 Domain of unknown function (DUF955); Region: DUF955; cl01076 1205674000055 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1205674000056 transposase; Provisional; Region: PRK06526 1205674000057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674000058 Walker A motif; other site 1205674000059 ATP binding site [chemical binding]; other site 1205674000060 Walker B motif; other site 1205674000061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205674000062 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1205674000063 Integrase core domain; Region: rve; pfam00665 1205674000064 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674000065 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1205674000066 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1205674000067 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1205674000068 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205674000069 active site 1205674000070 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205674000071 putative septation inhibitor protein; Reviewed; Region: PRK00159 1205674000072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205674000073 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205674000074 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1205674000075 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1205674000076 glutamine binding [chemical binding]; other site 1205674000077 catalytic triad [active] 1205674000078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674000079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674000080 active site 1205674000081 ATP binding site [chemical binding]; other site 1205674000082 substrate binding site [chemical binding]; other site 1205674000083 activation loop (A-loop); other site 1205674000084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1205674000085 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205674000086 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205674000087 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205674000088 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205674000089 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674000090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674000091 active site 1205674000092 ATP binding site [chemical binding]; other site 1205674000093 substrate binding site [chemical binding]; other site 1205674000094 activation loop (A-loop); other site 1205674000095 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205674000096 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205674000097 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1205674000098 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1205674000099 active site 1205674000100 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674000101 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674000102 phosphopeptide binding site; other site 1205674000103 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1205674000104 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674000105 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674000106 phosphopeptide binding site; other site 1205674000107 Nitronate monooxygenase; Region: NMO; pfam03060 1205674000108 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205674000109 FMN binding site [chemical binding]; other site 1205674000110 substrate binding site [chemical binding]; other site 1205674000111 putative catalytic residue [active] 1205674000112 Ras GTPase Activating Domain; Region: RasGAP; cl02569 1205674000113 Transcription factor WhiB; Region: Whib; pfam02467 1205674000114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205674000115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674000116 non-specific DNA binding site [nucleotide binding]; other site 1205674000117 salt bridge; other site 1205674000118 sequence-specific DNA binding site [nucleotide binding]; other site 1205674000119 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205674000120 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205674000121 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205674000122 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205674000123 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205674000124 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1205674000125 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1205674000126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1205674000127 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1205674000128 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1205674000129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674000130 catalytic residue [active] 1205674000131 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1205674000132 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1205674000133 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1205674000134 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674000135 acyl-activating enzyme (AAE) consensus motif; other site 1205674000136 active site 1205674000137 TIGR03084 family protein; Region: TIGR03084 1205674000138 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205674000139 Wyosine base formation; Region: Wyosine_form; pfam08608 1205674000140 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205674000141 hypothetical protein; Validated; Region: PRK00228 1205674000142 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205674000143 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1205674000144 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674000145 active site 1205674000146 HIGH motif; other site 1205674000147 nucleotide binding site [chemical binding]; other site 1205674000148 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1205674000149 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674000150 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674000151 active site 1205674000152 KMSKS motif; other site 1205674000153 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1205674000154 tRNA binding surface [nucleotide binding]; other site 1205674000155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205674000156 MarR family; Region: MarR; pfam01047 1205674000157 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205674000158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674000159 DNA-binding site [nucleotide binding]; DNA binding site 1205674000160 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1205674000161 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674000162 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674000163 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1205674000164 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1205674000165 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205674000166 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205674000167 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205674000168 Transglycosylase; Region: Transgly; pfam00912 1205674000169 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1205674000170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205674000171 Predicted integral membrane protein [Function unknown]; Region: COG5650 1205674000172 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1205674000173 conserved cys residue [active] 1205674000174 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1205674000175 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1205674000176 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1205674000177 dimer interface [polypeptide binding]; other site 1205674000178 ssDNA binding site [nucleotide binding]; other site 1205674000179 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1205674000180 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1205674000181 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1205674000182 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1205674000183 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1205674000184 replicative DNA helicase; Validated; Region: PRK07773 1205674000185 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1205674000186 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1205674000187 Walker A motif; other site 1205674000188 ATP binding site [chemical binding]; other site 1205674000189 Walker B motif; other site 1205674000190 DNA binding loops [nucleotide binding] 1205674000191 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205674000192 protein-splicing catalytic site; other site 1205674000193 thioester formation/cholesterol transfer; other site 1205674000194 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205674000195 protein-splicing catalytic site; other site 1205674000196 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205674000197 Evidence 5 : No homology to any previously reported sequences; PubMedId : 11929527, 12657046 1205674000198 Evidence 5 : No homology to any previously reported sequences 1205674000199 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1205674000200 ADP-ribose binding site [chemical binding]; other site 1205674000201 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1205674000202 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1205674000203 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674000204 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674000205 Berberine and berberine like; Region: BBE; pfam08031 1205674000206 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205674000207 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205674000208 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1205674000209 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1205674000210 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1205674000211 DNA binding residues [nucleotide binding] 1205674000212 dimer interface [polypeptide binding]; other site 1205674000213 metal binding site [ion binding]; metal-binding site 1205674000214 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1205674000215 hypothetical protein; Validated; Region: PRK00068 1205674000216 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205674000217 homotetrameric interface [polypeptide binding]; other site 1205674000218 putative active site [active] 1205674000219 metal binding site [ion binding]; metal-binding site 1205674000220 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1205674000221 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1205674000222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000224 short chain dehydrogenase; Provisional; Region: PRK06197 1205674000225 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205674000226 putative NAD(P) binding site [chemical binding]; other site 1205674000227 active site 1205674000228 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1205674000229 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1205674000230 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1205674000231 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1205674000232 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1205674000233 dimer interface [polypeptide binding]; other site 1205674000234 active site 1205674000235 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1205674000236 folate binding site [chemical binding]; other site 1205674000237 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674000238 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674000239 active site 1205674000240 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205674000241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205674000242 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205674000243 Walker A/P-loop; other site 1205674000244 ATP binding site [chemical binding]; other site 1205674000245 Q-loop/lid; other site 1205674000246 ABC transporter signature motif; other site 1205674000247 Walker B; other site 1205674000248 D-loop; other site 1205674000249 H-loop/switch region; other site 1205674000250 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674000251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674000252 ligand binding site [chemical binding]; other site 1205674000253 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205674000254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205674000255 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205674000256 active site 1205674000257 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1205674000258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674000260 homodimer interface [polypeptide binding]; other site 1205674000261 catalytic residue [active] 1205674000262 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674000263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000265 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1205674000266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674000267 dimerization interface [polypeptide binding]; other site 1205674000268 putative DNA binding site [nucleotide binding]; other site 1205674000269 putative Zn2+ binding site [ion binding]; other site 1205674000270 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1205674000271 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205674000272 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1205674000273 NADH dehydrogenase; Region: NADHdh; cl00469 1205674000274 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1205674000275 hydrogenase 4 subunit F; Validated; Region: PRK06458 1205674000276 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205674000277 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1205674000278 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1205674000279 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1205674000280 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1205674000281 putative hydrophobic ligand binding site [chemical binding]; other site 1205674000282 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205674000283 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674000284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674000285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674000286 S-adenosylmethionine binding site [chemical binding]; other site 1205674000287 Predicted membrane protein [Function unknown]; Region: COG3305 1205674000288 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1205674000289 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1205674000290 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205674000291 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205674000292 metal-binding site [ion binding] 1205674000293 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674000294 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205674000295 Predicted integral membrane protein [Function unknown]; Region: COG5660 1205674000296 Putative zinc-finger; Region: zf-HC2; pfam13490 1205674000297 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674000298 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674000299 active site 1205674000300 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000301 PPE family; Region: PPE; pfam00823 1205674000302 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1205674000303 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1205674000304 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1205674000305 acyl-CoA synthetase; Validated; Region: PRK05857 1205674000306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000308 acyl-activating enzyme (AAE) consensus motif; other site 1205674000309 acyl-activating enzyme (AAE) consensus motif; other site 1205674000310 AMP binding site [chemical binding]; other site 1205674000311 active site 1205674000312 CoA binding site [chemical binding]; other site 1205674000313 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674000314 AMP-binding enzyme; Region: AMP-binding; pfam00501 1205674000315 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000316 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000317 acyl-activating enzyme (AAE) consensus motif; other site 1205674000318 acyl-activating enzyme (AAE) consensus motif; other site 1205674000319 active site 1205674000320 AMP binding site [chemical binding]; other site 1205674000321 CoA binding site [chemical binding]; other site 1205674000322 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674000323 Condensation domain; Region: Condensation; pfam00668 1205674000324 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205674000325 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205674000326 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205674000327 acyl-activating enzyme (AAE) consensus motif; other site 1205674000328 AMP binding site [chemical binding]; other site 1205674000329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674000330 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1205674000331 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1205674000332 putative NAD(P) binding site [chemical binding]; other site 1205674000333 active site 1205674000334 putative substrate binding site [chemical binding]; other site 1205674000335 Predicted membrane protein [Function unknown]; Region: COG3336 1205674000336 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205674000337 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205674000338 metal-binding site [ion binding] 1205674000339 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674000340 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205674000341 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674000342 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674000343 ligand binding site [chemical binding]; other site 1205674000344 flexible hinge region; other site 1205674000345 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205674000346 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1205674000347 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1205674000348 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205674000349 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674000350 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1205674000351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674000352 motif II; other site 1205674000353 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205674000354 PE family; Region: PE; pfam00934 1205674000355 Rhomboid family; Region: Rhomboid; pfam01694 1205674000356 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205674000357 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1205674000358 active site 1205674000359 catalytic triad [active] 1205674000360 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205674000361 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1205674000362 NADP-binding site; other site 1205674000363 homotetramer interface [polypeptide binding]; other site 1205674000364 substrate binding site [chemical binding]; other site 1205674000365 homodimer interface [polypeptide binding]; other site 1205674000366 active site 1205674000367 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1205674000368 dimer interface [polypeptide binding]; other site 1205674000369 active site 1205674000370 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1205674000371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674000372 active site 1205674000373 motif I; other site 1205674000374 motif II; other site 1205674000375 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1205674000376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205674000377 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205674000378 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205674000379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205674000380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205674000381 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1205674000382 dimerization interface [polypeptide binding]; other site 1205674000383 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1205674000384 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205674000385 PYR/PP interface [polypeptide binding]; other site 1205674000386 dimer interface [polypeptide binding]; other site 1205674000387 TPP binding site [chemical binding]; other site 1205674000388 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205674000389 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1205674000390 TPP-binding site; other site 1205674000391 dimer interface [polypeptide binding]; other site 1205674000392 acyl-CoA synthetase; Validated; Region: PRK05852 1205674000393 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000394 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1205674000395 acyl-activating enzyme (AAE) consensus motif; other site 1205674000396 acyl-activating enzyme (AAE) consensus motif; other site 1205674000397 putative AMP binding site [chemical binding]; other site 1205674000398 putative active site [active] 1205674000399 putative CoA binding site [chemical binding]; other site 1205674000400 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1205674000401 elongation factor G; Reviewed; Region: PRK12740 1205674000402 G1 box; other site 1205674000403 putative GEF interaction site [polypeptide binding]; other site 1205674000404 GTP/Mg2+ binding site [chemical binding]; other site 1205674000405 Switch I region; other site 1205674000406 G2 box; other site 1205674000407 G3 box; other site 1205674000408 Switch II region; other site 1205674000409 G4 box; other site 1205674000410 G5 box; other site 1205674000411 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205674000412 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205674000413 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205674000414 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1205674000415 PE family; Region: PE; pfam00934 1205674000416 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1205674000417 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205674000418 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205674000419 trehalose synthase; Region: treS_nterm; TIGR02456 1205674000420 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1205674000421 active site 1205674000422 catalytic site [active] 1205674000423 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1205674000424 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1205674000425 Predicted membrane protein [Function unknown]; Region: COG3619 1205674000426 Predicted esterase [General function prediction only]; Region: COG0627 1205674000427 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1205674000428 putative active site [active] 1205674000429 putative catalytic site [active] 1205674000430 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674000431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674000432 active site 1205674000433 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1205674000434 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674000435 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1205674000436 Coenzyme A binding pocket [chemical binding]; other site 1205674000437 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674000438 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1205674000439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000441 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674000442 Cytochrome P450; Region: p450; cl12078 1205674000443 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1205674000444 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205674000445 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1205674000446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674000447 NAD(P) binding site [chemical binding]; other site 1205674000448 active site 1205674000449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205674000450 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1205674000451 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1205674000452 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205674000453 minor groove reading motif; other site 1205674000454 helix-hairpin-helix signature motif; other site 1205674000455 active site 1205674000456 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1205674000457 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1205674000458 Cl- selectivity filter; other site 1205674000459 Cl- binding residues [ion binding]; other site 1205674000460 pore gating glutamate residue; other site 1205674000461 dimer interface [polypeptide binding]; other site 1205674000462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000464 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674000465 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674000466 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674000467 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674000468 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1205674000469 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1205674000470 NAD(P) binding site [chemical binding]; other site 1205674000471 catalytic residues [active] 1205674000472 short chain dehydrogenase; Provisional; Region: PRK07791 1205674000473 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1205674000474 NAD binding site [chemical binding]; other site 1205674000475 homodimer interface [polypeptide binding]; other site 1205674000476 active site 1205674000477 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205674000478 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1205674000479 NAD(P) binding site [chemical binding]; other site 1205674000480 PE family; Region: PE; pfam00934 1205674000481 PE-PPE domain; Region: PE-PPE; pfam08237 1205674000482 PE family; Region: PE; pfam00934 1205674000483 PE-PPE domain; Region: PE-PPE; pfam08237 1205674000484 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1205674000485 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1205674000486 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1205674000487 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674000488 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1205674000489 FAD binding site [chemical binding]; other site 1205674000490 substrate binding site [chemical binding]; other site 1205674000491 catalytic base [active] 1205674000492 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1205674000493 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10510226; Product type pe : putative enzyme 1205674000494 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205674000495 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1205674000496 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1205674000497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000499 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1205674000500 PE family; Region: PE; pfam00934 1205674000501 PE-PPE domain; Region: PE-PPE; pfam08237 1205674000502 PE family; Region: PE; pfam00934 1205674000503 PE-PPE domain; Region: PE-PPE; pfam08237 1205674000504 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674000505 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674000506 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1205674000507 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205674000508 NAD(P) binding site [chemical binding]; other site 1205674000509 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205674000510 active site 1205674000511 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205674000512 putative hydrophobic ligand binding site [chemical binding]; other site 1205674000513 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205674000514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674000515 DNA-binding site [nucleotide binding]; DNA binding site 1205674000516 FCD domain; Region: FCD; pfam07729 1205674000517 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1205674000518 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000519 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205674000520 acyl-activating enzyme (AAE) consensus motif; other site 1205674000521 acyl-activating enzyme (AAE) consensus motif; other site 1205674000522 putative AMP binding site [chemical binding]; other site 1205674000523 putative active site [active] 1205674000524 putative CoA binding site [chemical binding]; other site 1205674000525 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674000526 Permease; Region: Permease; pfam02405 1205674000527 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674000528 Permease; Region: Permease; pfam02405 1205674000529 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674000530 mce related protein; Region: MCE; pfam02470 1205674000531 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674000532 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674000533 mce related protein; Region: MCE; pfam02470 1205674000534 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674000535 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674000536 mce related protein; Region: MCE; pfam02470 1205674000537 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674000538 mce related protein; Region: MCE; pfam02470 1205674000539 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674000540 mce related protein; Region: MCE; pfam02470 1205674000541 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674000542 mce related protein; Region: MCE; pfam02470 1205674000543 RDD family; Region: RDD; pfam06271 1205674000544 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1205674000545 Predicted membrane protein [Function unknown]; Region: COG1511 1205674000546 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1205674000547 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1205674000548 Pirin-related protein [General function prediction only]; Region: COG1741 1205674000549 Pirin; Region: Pirin; pfam02678 1205674000550 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1205674000551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674000552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674000553 DNA binding residues [nucleotide binding] 1205674000554 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205674000555 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1205674000556 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205674000557 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1205674000558 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1205674000559 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1205674000560 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205674000561 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1205674000562 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1205674000563 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205674000564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674000565 S-adenosylmethionine binding site [chemical binding]; other site 1205674000566 SPW repeat; Region: SPW; pfam03779 1205674000567 SPW repeat; Region: SPW; pfam03779 1205674000568 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1205674000569 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1205674000570 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205674000571 putative homodimer interface [polypeptide binding]; other site 1205674000572 putative homotetramer interface [polypeptide binding]; other site 1205674000573 putative allosteric switch controlling residues; other site 1205674000574 putative metal binding site [ion binding]; other site 1205674000575 putative homodimer-homodimer interface [polypeptide binding]; other site 1205674000576 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205674000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674000578 putative substrate translocation pore; other site 1205674000579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205674000580 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205674000581 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205674000582 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205674000583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205674000584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674000585 Walker A/P-loop; other site 1205674000586 ATP binding site [chemical binding]; other site 1205674000587 Q-loop/lid; other site 1205674000588 ABC transporter signature motif; other site 1205674000589 Walker B; other site 1205674000590 D-loop; other site 1205674000591 H-loop/switch region; other site 1205674000592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205674000593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674000594 Walker A/P-loop; other site 1205674000595 ATP binding site [chemical binding]; other site 1205674000596 Q-loop/lid; other site 1205674000597 ABC transporter signature motif; other site 1205674000598 Walker B; other site 1205674000599 D-loop; other site 1205674000600 H-loop/switch region; other site 1205674000601 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674000602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674000603 dimerization interface [polypeptide binding]; other site 1205674000604 DNA binding residues [nucleotide binding] 1205674000605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000607 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1205674000608 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674000609 molybdopterin cofactor binding site; other site 1205674000610 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674000611 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1205674000612 putative molybdopterin cofactor binding site; other site 1205674000613 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674000614 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205674000615 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674000616 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1205674000617 Predicted integral membrane protein [Function unknown]; Region: COG0392 1205674000618 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205674000619 MMPL family; Region: MMPL; pfam03176 1205674000620 MMPL family; Region: MMPL; pfam03176 1205674000621 LabA_like proteins; Region: LabA_like; cd06167 1205674000622 putative metal binding site [ion binding]; other site 1205674000623 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1205674000624 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1205674000625 active site 1205674000626 substrate-binding site [chemical binding]; other site 1205674000627 metal-binding site [ion binding] 1205674000628 GTP binding site [chemical binding]; other site 1205674000629 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1205674000630 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674000631 active site 1205674000632 nucleotide binding site [chemical binding]; other site 1205674000633 HIGH motif; other site 1205674000634 KMSKS motif; other site 1205674000635 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1205674000636 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1205674000637 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1205674000638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674000639 FeS/SAM binding site; other site 1205674000640 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1205674000641 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000642 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205674000643 acyl-activating enzyme (AAE) consensus motif; other site 1205674000644 acyl-activating enzyme (AAE) consensus motif; other site 1205674000645 putative AMP binding site [chemical binding]; other site 1205674000646 putative active site [active] 1205674000647 putative CoA binding site [chemical binding]; other site 1205674000648 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674000649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674000650 active site 1205674000651 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1205674000652 putative active site [active] 1205674000653 putative catalytic site [active] 1205674000654 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205674000655 active site 2 [active] 1205674000656 active site 1 [active] 1205674000657 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205674000658 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674000659 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1205674000660 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1205674000661 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1205674000662 Moco binding site; other site 1205674000663 metal coordination site [ion binding]; other site 1205674000664 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674000665 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205674000666 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674000667 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674000668 enoyl-CoA hydratase; Provisional; Region: PRK08252 1205674000669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674000670 substrate binding site [chemical binding]; other site 1205674000671 oxyanion hole (OAH) forming residues; other site 1205674000672 trimer interface [polypeptide binding]; other site 1205674000673 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1205674000674 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205674000675 NAD binding site [chemical binding]; other site 1205674000676 catalytic residues [active] 1205674000677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674000678 S-adenosylmethionine binding site [chemical binding]; other site 1205674000679 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205674000680 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205674000681 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1205674000682 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205674000683 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205674000684 putative active site [active] 1205674000685 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205674000686 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1205674000687 active site 1205674000688 substrate binding pocket [chemical binding]; other site 1205674000689 homodimer interaction site [polypeptide binding]; other site 1205674000690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674000691 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205674000692 active site 1205674000693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000695 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1205674000696 active site 1205674000697 diiron metal binding site [ion binding]; other site 1205674000698 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1205674000699 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1205674000700 NAD(P) binding site [chemical binding]; other site 1205674000701 catalytic residues [active] 1205674000702 Lipase maturation factor; Region: LMF1; pfam06762 1205674000703 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1205674000704 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1205674000705 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205674000706 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1205674000707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000709 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205674000710 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1205674000711 active site 2 [active] 1205674000712 active site 1 [active] 1205674000713 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1205674000714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674000715 NAD(P) binding site [chemical binding]; other site 1205674000716 active site 1205674000717 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1205674000718 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205674000719 dimer interface [polypeptide binding]; other site 1205674000720 active site 1205674000721 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1205674000722 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1205674000723 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1205674000724 FAD binding site [chemical binding]; other site 1205674000725 substrate binding site [chemical binding]; other site 1205674000726 catalytic residues [active] 1205674000727 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1205674000728 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205674000729 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1205674000730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674000731 catalytic loop [active] 1205674000732 iron binding site [ion binding]; other site 1205674000733 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1205674000734 L-aspartate oxidase; Provisional; Region: PRK06175 1205674000735 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205674000736 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1205674000737 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1205674000738 putative dimer interface [polypeptide binding]; other site 1205674000739 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1205674000740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674000741 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1205674000742 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205674000743 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1205674000744 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]; Region: CobU; COG2087 1205674000745 cobyric acid synthase; Provisional; Region: PRK00784 1205674000746 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1205674000747 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205674000748 catalytic triad [active] 1205674000749 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000750 PPE family; Region: PPE; pfam00823 1205674000751 Evidence 5 : No homology to any previously reported sequences 1205674000752 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205674000753 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1205674000754 putative active site [active] 1205674000755 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1205674000756 putative active site [active] 1205674000757 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1205674000758 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1205674000759 active site 1205674000760 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1205674000761 DNA binding site [nucleotide binding] 1205674000762 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205674000763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674000764 Coenzyme A binding pocket [chemical binding]; other site 1205674000765 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1205674000766 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1205674000767 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1205674000768 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205674000769 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205674000770 intersubunit interface [polypeptide binding]; other site 1205674000771 5-oxoprolinase; Region: PLN02666 1205674000772 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1205674000773 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1205674000774 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1205674000775 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205674000776 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 1205674000777 nucleotide binding site [chemical binding]; other site 1205674000778 acyl-CoA synthetase; Validated; Region: PRK07788 1205674000779 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000780 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674000781 active site 1205674000782 CoA binding site [chemical binding]; other site 1205674000783 AMP binding site [chemical binding]; other site 1205674000784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674000785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674000786 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205674000787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674000788 FAD binding site [chemical binding]; other site 1205674000789 substrate binding site [chemical binding]; other site 1205674000790 catalytic base [active] 1205674000791 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205674000792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000794 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1205674000795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674000796 Zn binding site [ion binding]; other site 1205674000797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205674000798 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205674000799 putative active site [active] 1205674000800 PE family; Region: PE; pfam00934 1205674000801 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000802 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000803 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674000804 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674000805 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205674000806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674000807 Walker A motif; other site 1205674000808 ATP binding site [chemical binding]; other site 1205674000809 Walker B motif; other site 1205674000810 arginine finger; other site 1205674000811 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205674000812 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205674000813 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674000814 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205674000815 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674000816 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674000817 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000818 PPE family; Region: PPE; pfam00823 1205674000819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205674000820 EspG family; Region: ESX-1_EspG; pfam14011 1205674000821 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205674000822 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205674000823 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205674000824 active site 1205674000825 catalytic residues [active] 1205674000826 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205674000827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205674000828 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1205674000829 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1205674000830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674000831 S-adenosylmethionine binding site [chemical binding]; other site 1205674000832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1205674000833 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674000834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674000835 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674000836 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205674000837 Sulfatase; Region: Sulfatase; cl17466 1205674000838 hypothetical protein; Region: PHA01748 1205674000839 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205674000840 putative active site [active] 1205674000841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674000844 protochlorophyllide reductase; Region: PLN00015 1205674000845 NAD(P) binding site [chemical binding]; other site 1205674000846 active site 1205674000847 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000848 PPE family; Region: PPE; pfam00823 1205674000849 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000850 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000851 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000852 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000853 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000854 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000855 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000856 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000857 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000858 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000859 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000860 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000861 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000862 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1205674000863 putative FMN binding site [chemical binding]; other site 1205674000864 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1205674000865 active site 1205674000866 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1205674000867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1205674000868 SnoaL-like domain; Region: SnoaL_4; pfam13577 1205674000869 SnoaL-like domain; Region: SnoaL_3; pfam13474 1205674000870 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1205674000871 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205674000872 nucleotide binding site [chemical binding]; other site 1205674000873 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1205674000874 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205674000875 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1205674000876 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1205674000877 active site 1205674000878 catalytic residues [active] 1205674000879 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1205674000880 Muconolactone delta-isomerase; Region: MIase; cl01992 1205674000881 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1205674000882 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205674000883 putative active site [active] 1205674000884 catalytic site [active] 1205674000885 putative metal binding site [ion binding]; other site 1205674000886 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1205674000887 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1205674000888 putative substrate binding pocket [chemical binding]; other site 1205674000889 AC domain interface; other site 1205674000890 catalytic triad [active] 1205674000891 AB domain interface; other site 1205674000892 interchain disulfide; other site 1205674000893 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205674000894 trimer interface [polypeptide binding]; other site 1205674000895 active site 1205674000896 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1205674000897 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205674000898 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1205674000899 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1205674000900 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1205674000901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674000902 dimerization interface [polypeptide binding]; other site 1205674000903 putative DNA binding site [nucleotide binding]; other site 1205674000904 putative Zn2+ binding site [ion binding]; other site 1205674000905 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205674000906 active site residue [active] 1205674000907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674000908 S-adenosylmethionine binding site [chemical binding]; other site 1205674000909 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674000910 Cytochrome P450; Region: p450; cl12078 1205674000911 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1205674000912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000913 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205674000914 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1205674000915 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1205674000916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674000917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674000918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205674000919 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205674000920 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205674000921 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205674000922 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1205674000923 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1205674000924 substrate binding site; other site 1205674000925 tetramer interface; other site 1205674000926 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674000927 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674000928 active site 1205674000929 aminotransferase AlaT; Validated; Region: PRK09265 1205674000930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674000931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674000932 homodimer interface [polypeptide binding]; other site 1205674000933 catalytic residue [active] 1205674000934 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1205674000935 4Fe-4S binding domain; Region: Fer4; pfam00037 1205674000936 Cysteine-rich domain; Region: CCG; pfam02754 1205674000937 Cysteine-rich domain; Region: CCG; pfam02754 1205674000938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674000939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674000940 DNA binding residues [nucleotide binding] 1205674000941 dimerization interface [polypeptide binding]; other site 1205674000942 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1205674000943 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205674000944 G1 box; other site 1205674000945 GTP/Mg2+ binding site [chemical binding]; other site 1205674000946 G2 box; other site 1205674000947 Switch I region; other site 1205674000948 G3 box; other site 1205674000949 Switch II region; other site 1205674000950 G4 box; other site 1205674000951 G5 box; other site 1205674000952 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1205674000953 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205674000954 G1 box; other site 1205674000955 GTP/Mg2+ binding site [chemical binding]; other site 1205674000956 G2 box; other site 1205674000957 Switch I region; other site 1205674000958 G3 box; other site 1205674000959 Switch II region; other site 1205674000960 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205674000961 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1205674000962 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1205674000963 nucleotide binding site [chemical binding]; other site 1205674000964 NEF interaction site [polypeptide binding]; other site 1205674000965 SBD interface [polypeptide binding]; other site 1205674000966 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1205674000967 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1205674000968 dimer interface [polypeptide binding]; other site 1205674000969 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1205674000970 chaperone protein DnaJ; Provisional; Region: PRK14279 1205674000971 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205674000972 HSP70 interaction site [polypeptide binding]; other site 1205674000973 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205674000974 Zn binding sites [ion binding]; other site 1205674000975 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205674000976 dimer interface [polypeptide binding]; other site 1205674000977 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1205674000978 DNA binding residues [nucleotide binding] 1205674000979 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205674000980 putative dimer interface [polypeptide binding]; other site 1205674000981 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000982 PPE family; Region: PPE; pfam00823 1205674000983 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000984 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000985 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000986 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000987 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000988 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674000989 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000990 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674000991 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205674000992 CoenzymeA binding site [chemical binding]; other site 1205674000993 subunit interaction site [polypeptide binding]; other site 1205674000994 PHB binding site; other site 1205674000995 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1205674000996 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1205674000997 GDP-binding site [chemical binding]; other site 1205674000998 ACT binding site; other site 1205674000999 IMP binding site; other site 1205674001000 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1205674001001 Peptidase family M50; Region: Peptidase_M50; pfam02163 1205674001002 active site 1205674001003 putative substrate binding region [chemical binding]; other site 1205674001004 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1205674001005 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1205674001006 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1205674001007 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1205674001008 Divalent cation transporter; Region: MgtE; pfam01769 1205674001009 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1205674001010 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1205674001011 active site 1205674001012 intersubunit interface [polypeptide binding]; other site 1205674001013 zinc binding site [ion binding]; other site 1205674001014 Na+ binding site [ion binding]; other site 1205674001015 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1205674001016 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1205674001017 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1205674001018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1205674001019 AAA domain; Region: AAA_33; pfam13671 1205674001020 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1205674001021 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1205674001022 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1205674001023 metal ion-dependent adhesion site (MIDAS); other site 1205674001024 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1205674001025 putative hydrophobic ligand binding site [chemical binding]; other site 1205674001026 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205674001027 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1205674001028 Ligand binding site; other site 1205674001029 metal-binding site 1205674001030 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1205674001031 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205674001032 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205674001033 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1205674001034 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1205674001035 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1205674001036 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1205674001037 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674001038 catalytic loop [active] 1205674001039 iron binding site [ion binding]; other site 1205674001040 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1205674001041 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1205674001042 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1205674001043 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205674001044 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1205674001045 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205674001046 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205674001047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205674001048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205674001049 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1205674001050 dimerization interface [polypeptide binding]; other site 1205674001051 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1205674001052 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205674001053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674001054 active site 1205674001055 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1205674001056 Clp amino terminal domain; Region: Clp_N; pfam02861 1205674001057 Clp amino terminal domain; Region: Clp_N; pfam02861 1205674001058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674001059 Walker A motif; other site 1205674001060 ATP binding site [chemical binding]; other site 1205674001061 Walker B motif; other site 1205674001062 arginine finger; other site 1205674001063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674001064 Walker A motif; other site 1205674001065 ATP binding site [chemical binding]; other site 1205674001066 Walker B motif; other site 1205674001067 arginine finger; other site 1205674001068 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205674001069 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1205674001070 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1205674001071 heme-binding site [chemical binding]; other site 1205674001072 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1205674001073 FAD binding pocket [chemical binding]; other site 1205674001074 FAD binding motif [chemical binding]; other site 1205674001075 phosphate binding motif [ion binding]; other site 1205674001076 beta-alpha-beta structure motif; other site 1205674001077 NAD binding pocket [chemical binding]; other site 1205674001078 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674001079 cyclase homology domain; Region: CHD; cd07302 1205674001080 nucleotidyl binding site; other site 1205674001081 metal binding site [ion binding]; metal-binding site 1205674001082 dimer interface [polypeptide binding]; other site 1205674001083 Predicted ATPase [General function prediction only]; Region: COG3903 1205674001084 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205674001085 Walker A motif; other site 1205674001086 ATP binding site [chemical binding]; other site 1205674001087 Walker B motif; other site 1205674001088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674001089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674001090 DNA binding residues [nucleotide binding] 1205674001091 dimerization interface [polypeptide binding]; other site 1205674001092 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674001093 PPE family; Region: PPE; pfam00823 1205674001094 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1205674001095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205674001096 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1205674001097 active site residue [active] 1205674001098 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1205674001099 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205674001100 homodimer interface [polypeptide binding]; other site 1205674001101 substrate-cofactor binding pocket; other site 1205674001102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674001103 catalytic residue [active] 1205674001104 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205674001105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674001106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674001107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674001108 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674001109 active site 1205674001110 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1205674001111 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674001112 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205674001113 acyl-CoA synthetase; Validated; Region: PRK05850 1205674001114 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674001115 acyl-activating enzyme (AAE) consensus motif; other site 1205674001116 active site 1205674001117 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1205674001118 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674001119 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205674001120 active site 1205674001121 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205674001122 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674001123 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674001124 Thioesterase; Region: PKS_TE; smart00824 1205674001125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205674001126 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1205674001127 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1205674001128 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674001129 phosphate acetyltransferase; Reviewed; Region: PRK05632 1205674001130 DRTGG domain; Region: DRTGG; pfam07085 1205674001131 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1205674001132 propionate/acetate kinase; Provisional; Region: PRK12379 1205674001133 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1205674001134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674001135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674001136 active site 1205674001137 ATP binding site [chemical binding]; other site 1205674001138 substrate binding site [chemical binding]; other site 1205674001139 activation loop (A-loop); other site 1205674001140 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205674001141 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1205674001142 substrate binding pocket [chemical binding]; other site 1205674001143 membrane-bound complex binding site; other site 1205674001144 hinge residues; other site 1205674001145 NUDIX domain; Region: NUDIX; pfam00293 1205674001146 nudix motif; other site 1205674001147 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1205674001148 thiamine phosphate binding site [chemical binding]; other site 1205674001149 active site 1205674001150 pyrophosphate binding site [ion binding]; other site 1205674001151 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1205674001152 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1205674001153 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1205674001154 thiS-thiF/thiG interaction site; other site 1205674001155 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1205674001156 ThiS interaction site; other site 1205674001157 putative active site [active] 1205674001158 tetramer interface [polypeptide binding]; other site 1205674001159 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205674001160 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1205674001161 PA/protease or protease-like domain interface [polypeptide binding]; other site 1205674001162 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1205674001163 Peptidase family M28; Region: Peptidase_M28; pfam04389 1205674001164 active site 1205674001165 metal binding site [ion binding]; metal-binding site 1205674001166 Predicted metalloprotease [General function prediction only]; Region: COG2321 1205674001167 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1205674001168 Zn binding site [ion binding]; other site 1205674001169 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205674001170 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1205674001171 dimer interface [polypeptide binding]; other site 1205674001172 substrate binding site [chemical binding]; other site 1205674001173 ATP binding site [chemical binding]; other site 1205674001174 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1205674001175 ThiC-associated domain; Region: ThiC-associated; pfam13667 1205674001176 ThiC family; Region: ThiC; pfam01964 1205674001177 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674001178 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1205674001179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674001180 motif II; other site 1205674001181 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205674001182 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1205674001183 putative catalytic site [active] 1205674001184 putative phosphate binding site [ion binding]; other site 1205674001185 active site 1205674001186 metal binding site A [ion binding]; metal-binding site 1205674001187 DNA binding site [nucleotide binding] 1205674001188 putative AP binding site [nucleotide binding]; other site 1205674001189 putative metal binding site B [ion binding]; other site 1205674001190 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1205674001191 active site 1205674001192 catalytic residues [active] 1205674001193 metal binding site [ion binding]; metal-binding site 1205674001194 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1205674001195 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205674001196 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1205674001197 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1205674001198 E-class dimer interface [polypeptide binding]; other site 1205674001199 P-class dimer interface [polypeptide binding]; other site 1205674001200 active site 1205674001201 Cu2+ binding site [ion binding]; other site 1205674001202 Zn2+ binding site [ion binding]; other site 1205674001203 carboxylate-amine ligase; Provisional; Region: PRK13517 1205674001204 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1205674001205 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1205674001206 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1205674001207 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1205674001208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674001209 Walker A motif; other site 1205674001210 ATP binding site [chemical binding]; other site 1205674001211 Walker B motif; other site 1205674001212 arginine finger; other site 1205674001213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674001214 Walker A motif; other site 1205674001215 ATP binding site [chemical binding]; other site 1205674001216 Walker B motif; other site 1205674001217 arginine finger; other site 1205674001218 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1205674001219 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1205674001220 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1205674001221 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205674001222 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205674001223 dimer interface [polypeptide binding]; other site 1205674001224 putative functional site; other site 1205674001225 putative MPT binding site; other site 1205674001226 short chain dehydrogenase; Provisional; Region: PRK06197 1205674001227 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205674001228 putative NAD(P) binding site [chemical binding]; other site 1205674001229 active site 1205674001230 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205674001231 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205674001232 ring oligomerisation interface [polypeptide binding]; other site 1205674001233 ATP/Mg binding site [chemical binding]; other site 1205674001234 stacking interactions; other site 1205674001235 hinge regions; other site 1205674001236 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1205674001237 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674001238 PPE family; Region: PPE; pfam00823 1205674001239 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1205674001240 DinB superfamily; Region: DinB_2; pfam12867 1205674001241 putative anti-sigmaE protein; Provisional; Region: PRK13920 1205674001242 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1205674001243 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1205674001244 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674001245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674001246 DNA binding residues [nucleotide binding] 1205674001247 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1205674001248 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001249 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 1205674001250 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1205674001251 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1205674001252 dimer interface [polypeptide binding]; other site 1205674001253 Transport protein; Region: actII; TIGR00833 1205674001254 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205674001255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674001256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674001257 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674001258 PPE family; Region: PPE; pfam00823 1205674001259 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674001260 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1205674001261 enoyl-CoA hydratase; Provisional; Region: PRK12478 1205674001262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674001263 substrate binding site [chemical binding]; other site 1205674001264 oxyanion hole (OAH) forming residues; other site 1205674001265 trimer interface [polypeptide binding]; other site 1205674001266 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1205674001267 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205674001268 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205674001269 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205674001270 NAD(P) binding site [chemical binding]; other site 1205674001271 catalytic residues [active] 1205674001272 Protein of unknown function (DUF779); Region: DUF779; cl01432 1205674001273 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1205674001274 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1205674001275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674001276 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205674001277 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205674001278 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205674001279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205674001280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674001281 non-specific DNA binding site [nucleotide binding]; other site 1205674001282 salt bridge; other site 1205674001283 sequence-specific DNA binding site [nucleotide binding]; other site 1205674001284 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1205674001285 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205674001286 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1205674001287 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1205674001288 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205674001289 active site 1205674001290 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205674001291 active site 2 [active] 1205674001292 isocitrate lyase; Provisional; Region: PRK15063 1205674001293 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1205674001294 oligomerization interface [polypeptide binding]; other site 1205674001295 active site 1205674001296 metal binding site [ion binding]; metal-binding site 1205674001297 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1205674001298 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205674001299 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205674001300 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001302 S-adenosylmethionine binding site [chemical binding]; other site 1205674001303 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674001305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001306 S-adenosylmethionine binding site [chemical binding]; other site 1205674001307 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1205674001308 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1205674001309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674001310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674001311 Predicted membrane protein [Function unknown]; Region: COG2733 1205674001312 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205674001313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674001314 non-specific DNA binding site [nucleotide binding]; other site 1205674001315 salt bridge; other site 1205674001316 sequence-specific DNA binding site [nucleotide binding]; other site 1205674001317 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1205674001318 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1205674001319 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1205674001320 intersubunit interface [polypeptide binding]; other site 1205674001321 active site 1205674001322 catalytic residue [active] 1205674001323 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205674001324 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1205674001325 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1205674001326 putative active site [active] 1205674001327 catalytic triad [active] 1205674001328 putative dimer interface [polypeptide binding]; other site 1205674001329 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1205674001330 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1205674001331 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674001332 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1205674001333 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205674001334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205674001335 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205674001336 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205674001337 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1205674001338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674001339 NAD(P) binding site [chemical binding]; other site 1205674001340 active site 1205674001341 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205674001342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205674001343 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1205674001344 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1205674001345 putative ADP-binding pocket [chemical binding]; other site 1205674001346 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1205674001347 L-lysine exporter; Region: 2a75; TIGR00948 1205674001348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674001349 catalytic core [active] 1205674001350 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1205674001351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674001352 dimer interface [polypeptide binding]; other site 1205674001353 phosphorylation site [posttranslational modification] 1205674001354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674001355 ATP binding site [chemical binding]; other site 1205674001356 Mg2+ binding site [ion binding]; other site 1205674001357 G-X-G motif; other site 1205674001358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674001359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674001360 active site 1205674001361 phosphorylation site [posttranslational modification] 1205674001362 intermolecular recognition site; other site 1205674001363 dimerization interface [polypeptide binding]; other site 1205674001364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674001365 DNA binding site [nucleotide binding] 1205674001366 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1205674001367 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205674001368 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205674001369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674001370 DNA-binding site [nucleotide binding]; DNA binding site 1205674001371 FCD domain; Region: FCD; pfam07729 1205674001372 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1205674001373 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1205674001374 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1205674001375 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1205674001376 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1205674001377 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1205674001378 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1205674001379 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1205674001380 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1205674001381 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205674001382 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205674001383 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1205674001384 putative NAD(P) binding site [chemical binding]; other site 1205674001385 active site 1205674001386 putative substrate binding site [chemical binding]; other site 1205674001387 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674001388 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205674001389 putative acyl-acceptor binding pocket; other site 1205674001390 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674001392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001393 S-adenosylmethionine binding site [chemical binding]; other site 1205674001394 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205674001395 active site 1205674001396 catalytic site [active] 1205674001397 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205674001398 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1205674001399 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205674001400 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674001401 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1205674001402 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1205674001403 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1205674001404 tRNA; other site 1205674001405 putative tRNA binding site [nucleotide binding]; other site 1205674001406 putative NADP binding site [chemical binding]; other site 1205674001407 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1205674001408 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1205674001409 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1205674001410 domain interfaces; other site 1205674001411 active site 1205674001412 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1205674001413 active site 1205674001414 homodimer interface [polypeptide binding]; other site 1205674001415 SAM binding site [chemical binding]; other site 1205674001416 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1205674001417 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1205674001418 active site 1205674001419 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1205674001420 dimer interface [polypeptide binding]; other site 1205674001421 active site 1205674001422 Schiff base residues; other site 1205674001423 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674001424 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674001425 active site 1205674001426 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205674001427 anti sigma factor interaction site; other site 1205674001428 regulatory phosphorylation site [posttranslational modification]; other site 1205674001429 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205674001430 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1205674001431 active site 1205674001432 catalytic triad [active] 1205674001433 oxyanion hole [active] 1205674001434 Evidence 4 : Homologs of previously reported genes of unknown function 1205674001435 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674001436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674001437 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205674001438 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205674001439 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1205674001440 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205674001441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674001442 catalytic residue [active] 1205674001443 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674001444 catalytic core [active] 1205674001445 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1205674001446 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205674001447 catalytic residues [active] 1205674001448 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205674001449 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205674001450 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1205674001451 ResB-like family; Region: ResB; pfam05140 1205674001452 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1205674001453 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674001454 AAA domain; Region: AAA_31; pfam13614 1205674001455 P-loop; other site 1205674001456 Magnesium ion binding site [ion binding]; other site 1205674001457 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1205674001458 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1205674001459 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1205674001460 dimer interface [polypeptide binding]; other site 1205674001461 active site 1205674001462 CoA binding pocket [chemical binding]; other site 1205674001463 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1205674001464 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205674001465 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1205674001466 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205674001467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674001468 NAD(P) binding site [chemical binding]; other site 1205674001469 active site 1205674001470 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1205674001471 Ligand binding site; other site 1205674001472 Putative Catalytic site; other site 1205674001473 DXD motif; other site 1205674001474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1205674001475 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1205674001476 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674001477 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674001478 acyl-activating enzyme (AAE) consensus motif; other site 1205674001479 acyl-activating enzyme (AAE) consensus motif; other site 1205674001480 AMP binding site [chemical binding]; other site 1205674001481 active site 1205674001482 CoA binding site [chemical binding]; other site 1205674001483 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1205674001484 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205674001485 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674001486 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205674001487 active site 1205674001488 short chain dehydrogenase; Provisional; Region: PRK05866 1205674001489 classical (c) SDRs; Region: SDR_c; cd05233 1205674001490 NAD(P) binding site [chemical binding]; other site 1205674001491 active site 1205674001492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674001493 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1205674001494 substrate binding site [chemical binding]; other site 1205674001495 oxyanion hole (OAH) forming residues; other site 1205674001496 trimer interface [polypeptide binding]; other site 1205674001497 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205674001498 putative active site [active] 1205674001499 homotetrameric interface [polypeptide binding]; other site 1205674001500 metal binding site [ion binding]; metal-binding site 1205674001501 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1205674001502 acyl-CoA synthetase; Validated; Region: PRK06188 1205674001503 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205674001504 putative active site [active] 1205674001505 putative CoA binding site [chemical binding]; other site 1205674001506 putative AMP binding site [chemical binding]; other site 1205674001507 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1205674001508 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1205674001509 active site 1205674001510 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1205674001511 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1205674001512 active site 1205674001513 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674001514 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205674001515 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205674001516 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1205674001517 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1205674001518 dimer interface [polypeptide binding]; other site 1205674001519 tetramer interface [polypeptide binding]; other site 1205674001520 PYR/PP interface [polypeptide binding]; other site 1205674001521 TPP binding site [chemical binding]; other site 1205674001522 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1205674001523 TPP-binding site; other site 1205674001524 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1205674001525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205674001526 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1205674001527 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1205674001528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001529 S-adenosylmethionine binding site [chemical binding]; other site 1205674001530 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674001531 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205674001532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001533 S-adenosylmethionine binding site [chemical binding]; other site 1205674001534 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1205674001535 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205674001536 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205674001537 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205674001538 substrate binding pocket [chemical binding]; other site 1205674001539 chain length determination region; other site 1205674001540 substrate-Mg2+ binding site; other site 1205674001541 catalytic residues [active] 1205674001542 aspartate-rich region 1; other site 1205674001543 active site lid residues [active] 1205674001544 aspartate-rich region 2; other site 1205674001545 heat shock protein HtpX; Provisional; Region: PRK03072 1205674001546 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1205674001547 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205674001548 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1205674001549 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674001550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205674001551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1205674001552 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1205674001553 O-methyltransferase; Region: Methyltransf_2; pfam00891 1205674001554 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674001555 Cytochrome P450; Region: p450; cl12078 1205674001556 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205674001557 ATP cone domain; Region: ATP-cone; pfam03477 1205674001558 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1205674001559 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1205674001560 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1205674001561 active site 1205674001562 dimer interface [polypeptide binding]; other site 1205674001563 effector binding site; other site 1205674001564 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1205674001565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674001566 active site 1205674001567 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205674001568 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1205674001569 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1205674001570 active site 1205674001571 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1205674001572 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1205674001573 putative active site [active] 1205674001574 putative metal binding site [ion binding]; other site 1205674001575 hypothetical protein; Provisional; Region: PRK07588 1205674001576 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205674001577 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1205674001578 ABC1 family; Region: ABC1; pfam03109 1205674001579 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674001580 Cytochrome P450; Region: p450; cl12078 1205674001581 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205674001582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674001583 Cytochrome P450; Region: p450; cl12078 1205674001584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674001585 dimerization interface [polypeptide binding]; other site 1205674001586 putative DNA binding site [nucleotide binding]; other site 1205674001587 putative Zn2+ binding site [ion binding]; other site 1205674001588 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1205674001589 putative hydrophobic ligand binding site [chemical binding]; other site 1205674001590 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205674001591 TIGR03086 family protein; Region: TIGR03086 1205674001592 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205674001593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674001594 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205674001595 PE family; Region: PE; pfam00934 1205674001596 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1205674001597 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1205674001598 Protein of unknown function DUF82; Region: DUF82; pfam01927 1205674001599 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674001600 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205674001601 putative active site [active] 1205674001602 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205674001603 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1205674001604 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1205674001605 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1205674001606 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205674001607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674001608 DNA-binding site [nucleotide binding]; DNA binding site 1205674001609 FCD domain; Region: FCD; pfam07729 1205674001610 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674001611 Permease; Region: Permease; pfam02405 1205674001612 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674001613 Permease; Region: Permease; pfam02405 1205674001614 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674001615 mce related protein; Region: MCE; pfam02470 1205674001616 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674001617 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1205674001618 mce related protein; Region: MCE; pfam02470 1205674001619 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674001620 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674001621 mce related protein; Region: MCE; pfam02470 1205674001622 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674001623 mce related protein; Region: MCE; pfam02470 1205674001624 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674001625 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674001626 mce related protein; Region: MCE; pfam02470 1205674001627 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674001628 mce related protein; Region: MCE; pfam02470 1205674001629 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205674001630 oligomeric interface; other site 1205674001631 putative active site [active] 1205674001632 homodimer interface [polypeptide binding]; other site 1205674001633 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205674001634 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1205674001635 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1205674001636 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1205674001637 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205674001638 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1205674001639 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1205674001640 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205674001641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674001642 Probable transposase; Region: OrfB_IS605; pfam01385 1205674001643 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1205674001644 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205674001645 putative active site [active] 1205674001646 SEC-C motif; Region: SEC-C; pfam02810 1205674001647 penicillin-binding protein 2; Provisional; Region: PRK10795 1205674001648 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205674001649 putative active site [active] 1205674001650 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1205674001651 dimer interface [polypeptide binding]; other site 1205674001652 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1205674001653 active site 1205674001654 galactokinase; Provisional; Region: PRK00555 1205674001655 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1205674001656 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674001657 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205674001658 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674001659 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205674001660 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205674001661 FIST N domain; Region: FIST; pfam08495 1205674001662 FIST C domain; Region: FIST_C; pfam10442 1205674001663 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1205674001664 AAA domain; Region: AAA_30; pfam13604 1205674001665 Family description; Region: UvrD_C_2; pfam13538 1205674001666 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1205674001667 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1205674001668 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1205674001669 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1205674001670 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205674001671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674001672 substrate binding site [chemical binding]; other site 1205674001673 oxyanion hole (OAH) forming residues; other site 1205674001674 trimer interface [polypeptide binding]; other site 1205674001675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205674001676 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205674001677 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1205674001678 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205674001679 active site 1205674001680 catalytic site [active] 1205674001681 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1205674001682 active site 1205674001683 catalytic site [active] 1205674001684 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205674001685 active site 1205674001686 catalytic site [active] 1205674001687 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1205674001688 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1205674001689 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1205674001690 putative homodimer interface [polypeptide binding]; other site 1205674001691 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1205674001692 heterodimer interface [polypeptide binding]; other site 1205674001693 homodimer interface [polypeptide binding]; other site 1205674001694 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1205674001695 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1205674001696 23S rRNA interface [nucleotide binding]; other site 1205674001697 L7/L12 interface [polypeptide binding]; other site 1205674001698 putative thiostrepton binding site; other site 1205674001699 L25 interface [polypeptide binding]; other site 1205674001700 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1205674001701 mRNA/rRNA interface [nucleotide binding]; other site 1205674001702 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001704 S-adenosylmethionine binding site [chemical binding]; other site 1205674001705 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674001707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001708 S-adenosylmethionine binding site [chemical binding]; other site 1205674001709 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674001711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001712 S-adenosylmethionine binding site [chemical binding]; other site 1205674001713 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674001714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674001715 S-adenosylmethionine binding site [chemical binding]; other site 1205674001716 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674001717 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205674001718 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1205674001719 ABC1 family; Region: ABC1; cl17513 1205674001720 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1205674001721 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1205674001722 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1205674001723 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1205674001724 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205674001725 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205674001726 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1205674001727 23S rRNA interface [nucleotide binding]; other site 1205674001728 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1205674001729 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1205674001730 core dimer interface [polypeptide binding]; other site 1205674001731 peripheral dimer interface [polypeptide binding]; other site 1205674001732 L10 interface [polypeptide binding]; other site 1205674001733 L11 interface [polypeptide binding]; other site 1205674001734 putative EF-Tu interaction site [polypeptide binding]; other site 1205674001735 putative EF-G interaction site [polypeptide binding]; other site 1205674001736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674001737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674001738 WHG domain; Region: WHG; pfam13305 1205674001739 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1205674001740 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1205674001741 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1205674001742 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1205674001743 Walker A/P-loop; other site 1205674001744 ATP binding site [chemical binding]; other site 1205674001745 Q-loop/lid; other site 1205674001746 ABC transporter signature motif; other site 1205674001747 Walker B; other site 1205674001748 D-loop; other site 1205674001749 H-loop/switch region; other site 1205674001750 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205674001751 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205674001752 CAAX protease self-immunity; Region: Abi; pfam02517 1205674001753 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205674001754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674001755 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674001756 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674001757 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674001758 Evidence 5 : No homology to any previously reported sequences 1205674001759 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15993073 1205674001760 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205674001761 Sulfatase; Region: Sulfatase; pfam00884 1205674001762 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205674001763 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205674001764 oligomeric interface; other site 1205674001765 putative active site [active] 1205674001766 homodimer interface [polypeptide binding]; other site 1205674001767 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1205674001768 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1205674001769 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1205674001770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1205674001771 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1205674001772 RPB10 interaction site [polypeptide binding]; other site 1205674001773 RPB1 interaction site [polypeptide binding]; other site 1205674001774 RPB11 interaction site [polypeptide binding]; other site 1205674001775 RPB3 interaction site [polypeptide binding]; other site 1205674001776 RPB12 interaction site [polypeptide binding]; other site 1205674001777 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1205674001778 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1205674001779 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1205674001780 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1205674001781 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1205674001782 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1205674001783 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1205674001784 G-loop; other site 1205674001785 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1205674001786 DNA binding site [nucleotide binding] 1205674001787 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1205674001788 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1205674001789 endonuclease IV; Provisional; Region: PRK01060 1205674001790 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1205674001791 AP (apurinic/apyrimidinic) site pocket; other site 1205674001792 DNA interaction; other site 1205674001793 Metal-binding active site; metal-binding site 1205674001794 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1205674001795 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1205674001796 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1205674001797 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674001798 active site 1205674001799 enoyl-CoA hydratase; Provisional; Region: PRK12478 1205674001800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674001801 substrate binding site [chemical binding]; other site 1205674001802 oxyanion hole (OAH) forming residues; other site 1205674001803 trimer interface [polypeptide binding]; other site 1205674001804 PaaX-like protein; Region: PaaX; pfam07848 1205674001805 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1205674001806 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205674001807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674001808 substrate binding site [chemical binding]; other site 1205674001809 oxyanion hole (OAH) forming residues; other site 1205674001810 trimer interface [polypeptide binding]; other site 1205674001811 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674001812 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205674001813 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1205674001814 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205674001815 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205674001816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674001817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674001818 WHG domain; Region: WHG; pfam13305 1205674001819 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1205674001820 S17 interaction site [polypeptide binding]; other site 1205674001821 S8 interaction site; other site 1205674001822 16S rRNA interaction site [nucleotide binding]; other site 1205674001823 streptomycin interaction site [chemical binding]; other site 1205674001824 23S rRNA interaction site [nucleotide binding]; other site 1205674001825 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1205674001826 30S ribosomal protein S7; Validated; Region: PRK05302 1205674001827 elongation factor G; Reviewed; Region: PRK00007 1205674001828 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1205674001829 G1 box; other site 1205674001830 putative GEF interaction site [polypeptide binding]; other site 1205674001831 GTP/Mg2+ binding site [chemical binding]; other site 1205674001832 Switch I region; other site 1205674001833 G2 box; other site 1205674001834 G3 box; other site 1205674001835 Switch II region; other site 1205674001836 G4 box; other site 1205674001837 G5 box; other site 1205674001838 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205674001839 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205674001840 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205674001841 elongation factor Tu; Reviewed; Region: PRK00049 1205674001842 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1205674001843 G1 box; other site 1205674001844 GEF interaction site [polypeptide binding]; other site 1205674001845 GTP/Mg2+ binding site [chemical binding]; other site 1205674001846 Switch I region; other site 1205674001847 G2 box; other site 1205674001848 G3 box; other site 1205674001849 Switch II region; other site 1205674001850 G4 box; other site 1205674001851 G5 box; other site 1205674001852 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205674001853 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1205674001854 Antibiotic Binding Site [chemical binding]; other site 1205674001855 Short C-terminal domain; Region: SHOCT; pfam09851 1205674001856 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1205674001857 classical (c) SDRs; Region: SDR_c; cd05233 1205674001858 NAD(P) binding site [chemical binding]; other site 1205674001859 active site 1205674001860 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205674001861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674001862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1205674001863 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205674001864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674001865 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1205674001866 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1205674001867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674001868 FeS/SAM binding site; other site 1205674001869 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1205674001870 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1205674001871 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205674001872 phosphate binding site [ion binding]; other site 1205674001873 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1205674001874 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1205674001875 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205674001876 Probable Catalytic site; other site 1205674001877 metal-binding site 1205674001878 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1205674001879 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205674001880 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1205674001881 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1205674001882 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1205674001883 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1205674001884 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1205674001885 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1205674001886 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1205674001887 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1205674001888 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1205674001889 putative translocon binding site; other site 1205674001890 protein-rRNA interface [nucleotide binding]; other site 1205674001891 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1205674001892 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1205674001893 G-X-X-G motif; other site 1205674001894 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1205674001895 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1205674001896 23S rRNA interface [nucleotide binding]; other site 1205674001897 5S rRNA interface [nucleotide binding]; other site 1205674001898 putative antibiotic binding site [chemical binding]; other site 1205674001899 L25 interface [polypeptide binding]; other site 1205674001900 L27 interface [polypeptide binding]; other site 1205674001901 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1205674001902 putative translocon interaction site; other site 1205674001903 23S rRNA interface [nucleotide binding]; other site 1205674001904 signal recognition particle (SRP54) interaction site; other site 1205674001905 L23 interface [polypeptide binding]; other site 1205674001906 trigger factor interaction site; other site 1205674001907 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1205674001908 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205674001909 Sulfatase; Region: Sulfatase; pfam00884 1205674001910 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1205674001911 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1205674001912 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1205674001913 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1205674001914 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1205674001915 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1205674001916 RNA binding site [nucleotide binding]; other site 1205674001917 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1205674001918 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1205674001919 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1205674001920 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1205674001921 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1205674001922 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205674001923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205674001924 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1205674001925 5S rRNA interface [nucleotide binding]; other site 1205674001926 23S rRNA interface [nucleotide binding]; other site 1205674001927 L5 interface [polypeptide binding]; other site 1205674001928 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1205674001929 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1205674001930 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1205674001931 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1205674001932 23S rRNA binding site [nucleotide binding]; other site 1205674001933 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1205674001934 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1205674001935 tandem repeat interface [polypeptide binding]; other site 1205674001936 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1205674001937 oligomer interface [polypeptide binding]; other site 1205674001938 active site residues [active] 1205674001939 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1205674001940 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1205674001941 tandem repeat interface [polypeptide binding]; other site 1205674001942 oligomer interface [polypeptide binding]; other site 1205674001943 active site residues [active] 1205674001944 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1205674001945 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674001946 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674001947 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674001948 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674001949 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1205674001950 intersubunit interface [polypeptide binding]; other site 1205674001951 active site 1205674001952 Zn2+ binding site [ion binding]; other site 1205674001953 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1205674001954 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205674001955 NAD binding site [chemical binding]; other site 1205674001956 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1205674001957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205674001958 nucleotide binding site [chemical binding]; other site 1205674001959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205674001960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674001961 Coenzyme A binding pocket [chemical binding]; other site 1205674001962 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674001963 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674001964 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1205674001965 SecY translocase; Region: SecY; pfam00344 1205674001966 adenylate kinase; Reviewed; Region: adk; PRK00279 1205674001967 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1205674001968 AMP-binding site [chemical binding]; other site 1205674001969 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1205674001970 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205674001971 active site 1205674001972 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1205674001973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674001974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674001975 DNA binding residues [nucleotide binding] 1205674001976 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1205674001977 Putative zinc-finger; Region: zf-HC2; pfam13490 1205674001978 MarR family; Region: MarR; pfam01047 1205674001979 TIGR03086 family protein; Region: TIGR03086 1205674001980 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205674001981 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205674001982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205674001983 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205674001984 Helix-turn-helix domain; Region: HTH_17; pfam12728 1205674001985 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674001986 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674001987 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205674001988 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1205674001989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674001990 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1205674001991 substrate binding pocket [chemical binding]; other site 1205674001992 FAD binding site [chemical binding]; other site 1205674001993 catalytic base [active] 1205674001994 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1205674001995 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1205674001996 tetrameric interface [polypeptide binding]; other site 1205674001997 NAD binding site [chemical binding]; other site 1205674001998 catalytic residues [active] 1205674001999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674002000 catalytic core [active] 1205674002001 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002002 PPE family; Region: PPE; pfam00823 1205674002003 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674002006 active site 1205674002007 phosphorylation site [posttranslational modification] 1205674002008 intermolecular recognition site; other site 1205674002009 dimerization interface [polypeptide binding]; other site 1205674002010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674002011 DNA binding site [nucleotide binding] 1205674002012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205674002013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674002014 dimerization interface [polypeptide binding]; other site 1205674002015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674002016 dimer interface [polypeptide binding]; other site 1205674002017 phosphorylation site [posttranslational modification] 1205674002018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674002019 ATP binding site [chemical binding]; other site 1205674002020 Mg2+ binding site [ion binding]; other site 1205674002021 G-X-G motif; other site 1205674002022 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1205674002023 nucleotide binding site/active site [active] 1205674002024 HIT family signature motif; other site 1205674002025 catalytic residue [active] 1205674002026 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1205674002027 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1205674002028 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205674002029 NAD binding site [chemical binding]; other site 1205674002030 catalytic Zn binding site [ion binding]; other site 1205674002031 substrate binding site [chemical binding]; other site 1205674002032 structural Zn binding site [ion binding]; other site 1205674002033 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205674002034 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205674002035 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674002036 Cytochrome P450; Region: p450; cl12078 1205674002037 short chain dehydrogenase; Provisional; Region: PRK07775 1205674002038 classical (c) SDRs; Region: SDR_c; cd05233 1205674002039 NAD(P) binding site [chemical binding]; other site 1205674002040 active site 1205674002041 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674002042 Cytochrome P450; Region: p450; cl12078 1205674002043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674002044 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1205674002045 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1205674002046 NAD binding site [chemical binding]; other site 1205674002047 catalytic residues [active] 1205674002048 short chain dehydrogenase; Provisional; Region: PRK07774 1205674002049 classical (c) SDRs; Region: SDR_c; cd05233 1205674002050 NAD(P) binding site [chemical binding]; other site 1205674002051 active site 1205674002052 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1205674002053 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1205674002054 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1205674002055 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1205674002056 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1205674002057 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1205674002058 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1205674002059 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1205674002060 Predicted esterase [General function prediction only]; Region: COG0627 1205674002061 S-formylglutathione hydrolase; Region: PLN02442 1205674002062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205674002063 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1205674002064 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1205674002065 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1205674002066 tetramer interface [polypeptide binding]; other site 1205674002067 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674002068 Cytochrome P450; Region: p450; cl12078 1205674002069 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1205674002070 ATP binding site [chemical binding]; other site 1205674002071 active site 1205674002072 substrate binding site [chemical binding]; other site 1205674002073 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1205674002074 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205674002075 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205674002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674002077 putative substrate translocation pore; other site 1205674002078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674002079 Predicted deacetylase [General function prediction only]; Region: COG3233 1205674002080 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1205674002081 putative active site [active] 1205674002082 putative Zn binding site [ion binding]; other site 1205674002083 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205674002084 FAD binding domain; Region: FAD_binding_2; pfam00890 1205674002085 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674002086 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674002087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674002088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205674002089 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1205674002090 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1205674002091 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1205674002092 putative active site [active] 1205674002093 catalytic triad [active] 1205674002094 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205674002095 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205674002096 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674002097 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205674002098 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205674002099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674002100 DNA-binding site [nucleotide binding]; DNA binding site 1205674002101 UTRA domain; Region: UTRA; pfam07702 1205674002102 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205674002103 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674002104 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674002105 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1205674002106 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205674002107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674002108 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205674002109 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1205674002110 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1205674002111 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1205674002112 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1205674002113 active site 1205674002114 metal binding site [ion binding]; metal-binding site 1205674002115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205674002116 active site 1205674002117 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205674002118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205674002119 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1205674002120 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1205674002121 dimerization interface [polypeptide binding]; other site 1205674002122 ATP binding site [chemical binding]; other site 1205674002123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1205674002124 dimerization interface [polypeptide binding]; other site 1205674002125 ATP binding site [chemical binding]; other site 1205674002126 CAAX protease self-immunity; Region: Abi; pfam02517 1205674002127 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205674002128 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1205674002129 active site 1205674002130 metal binding site [ion binding]; metal-binding site 1205674002131 hexamer interface [polypeptide binding]; other site 1205674002132 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1205674002133 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1205674002134 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1205674002135 active site 1205674002136 tetramer interface [polypeptide binding]; other site 1205674002137 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674002138 active site 1205674002139 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1205674002140 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1205674002141 dimerization interface [polypeptide binding]; other site 1205674002142 putative ATP binding site [chemical binding]; other site 1205674002143 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1205674002144 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1205674002145 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1205674002146 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1205674002147 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1205674002148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674002149 catalytic residue [active] 1205674002150 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1205674002151 heme-binding site [chemical binding]; other site 1205674002152 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1205674002153 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205674002154 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205674002155 active site residue [active] 1205674002156 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205674002157 active site residue [active] 1205674002158 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205674002159 catalytic residues [active] 1205674002160 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205674002161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674002162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674002163 DNA binding site [nucleotide binding] 1205674002164 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1205674002165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205674002166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674002167 Coenzyme A binding pocket [chemical binding]; other site 1205674002168 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1205674002169 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205674002170 Walker A/P-loop; other site 1205674002171 ATP binding site [chemical binding]; other site 1205674002172 Q-loop/lid; other site 1205674002173 ABC transporter signature motif; other site 1205674002174 Walker B; other site 1205674002175 D-loop; other site 1205674002176 H-loop/switch region; other site 1205674002177 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1205674002178 PhoU domain; Region: PhoU; pfam01895 1205674002179 PhoU domain; Region: PhoU; pfam01895 1205674002180 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1205674002181 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205674002182 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1205674002183 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1205674002184 FMN binding site [chemical binding]; other site 1205674002185 active site 1205674002186 catalytic residues [active] 1205674002187 substrate binding site [chemical binding]; other site 1205674002188 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1205674002189 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1205674002190 homodimer interface [polypeptide binding]; other site 1205674002191 putative substrate binding pocket [chemical binding]; other site 1205674002192 diiron center [ion binding]; other site 1205674002193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674002194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205674002195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674002196 dimerization interface [polypeptide binding]; other site 1205674002197 putative DNA binding site [nucleotide binding]; other site 1205674002198 putative Zn2+ binding site [ion binding]; other site 1205674002199 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205674002200 dimer interface [polypeptide binding]; other site 1205674002201 catalytic motif [active] 1205674002202 nucleoside/Zn binding site; other site 1205674002203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674002204 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674002205 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674002206 TIGR04255 family protein; Region: sporadTIGR04255 1205674002207 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1205674002208 putative transposase OrfB; Reviewed; Region: PHA02517 1205674002209 Protein of unknown function (DUF433); Region: DUF433; cl01030 1205674002210 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10537214, 11973159, 12775759 1205674002211 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10537214, 11973159, 12775759 1205674002212 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674002213 Evidence 4 : Homologs of previously reported genes of unknown function 1205674002214 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1205674002215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1205674002216 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1205674002217 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1205674002218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674002219 S-adenosylmethionine binding site [chemical binding]; other site 1205674002220 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1205674002221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674002222 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674002223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674002224 putative substrate translocation pore; other site 1205674002225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674002226 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1205674002227 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205674002228 tetramer interface [polypeptide binding]; other site 1205674002229 TPP-binding site [chemical binding]; other site 1205674002230 heterodimer interface [polypeptide binding]; other site 1205674002231 phosphorylation loop region [posttranslational modification] 1205674002232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674002233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674002234 active site 1205674002235 phosphorylation site [posttranslational modification] 1205674002236 intermolecular recognition site; other site 1205674002237 dimerization interface [polypeptide binding]; other site 1205674002238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674002239 DNA binding residues [nucleotide binding] 1205674002240 dimerization interface [polypeptide binding]; other site 1205674002241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205674002242 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205674002243 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1205674002244 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1205674002245 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1205674002246 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1205674002247 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205674002248 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205674002249 dimer interface [polypeptide binding]; other site 1205674002250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674002251 catalytic residue [active] 1205674002252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674002253 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1205674002254 putative substrate translocation pore; other site 1205674002255 TIGR04255 family protein; Region: sporadTIGR04255 1205674002256 short chain dehydrogenase; Provisional; Region: PRK05876 1205674002257 classical (c) SDRs; Region: SDR_c; cd05233 1205674002258 NAD(P) binding site [chemical binding]; other site 1205674002259 active site 1205674002260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674002261 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1205674002262 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1205674002263 dimer interface [polypeptide binding]; other site 1205674002264 PYR/PP interface [polypeptide binding]; other site 1205674002265 TPP binding site [chemical binding]; other site 1205674002266 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205674002267 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1205674002268 TPP-binding site [chemical binding]; other site 1205674002269 dimer interface [polypeptide binding]; other site 1205674002270 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205674002271 putative hydrophobic ligand binding site [chemical binding]; other site 1205674002272 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205674002273 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205674002274 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205674002275 putative hydrophobic ligand binding site [chemical binding]; other site 1205674002276 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205674002277 putative hydrophobic ligand binding site [chemical binding]; other site 1205674002278 aminotransferase; Validated; Region: PRK07777 1205674002279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674002280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674002281 homodimer interface [polypeptide binding]; other site 1205674002282 catalytic residue [active] 1205674002283 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1205674002284 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205674002285 dimer interface [polypeptide binding]; other site 1205674002286 active site 1205674002287 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1205674002288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674002289 substrate binding site [chemical binding]; other site 1205674002290 oxyanion hole (OAH) forming residues; other site 1205674002291 trimer interface [polypeptide binding]; other site 1205674002292 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205674002293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205674002294 hypothetical protein; Provisional; Region: PRK07588 1205674002295 hypothetical protein; Provisional; Region: PRK07236 1205674002296 hypothetical protein; Provisional; Region: PRK07236 1205674002297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674002298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674002299 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674002300 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205674002301 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1205674002302 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205674002303 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205674002304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674002305 ATP binding site [chemical binding]; other site 1205674002306 putative Mg++ binding site [ion binding]; other site 1205674002307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674002308 nucleotide binding region [chemical binding]; other site 1205674002309 ATP-binding site [chemical binding]; other site 1205674002310 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205674002311 WYL domain; Region: WYL; pfam13280 1205674002312 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205674002313 trimer interface [polypeptide binding]; other site 1205674002314 dimer interface [polypeptide binding]; other site 1205674002315 putative active site [active] 1205674002316 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1205674002317 MPT binding site; other site 1205674002318 trimer interface [polypeptide binding]; other site 1205674002319 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205674002320 MoaE homodimer interface [polypeptide binding]; other site 1205674002321 MoaD interaction [polypeptide binding]; other site 1205674002322 active site residues [active] 1205674002323 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205674002324 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205674002325 MoaE interaction surface [polypeptide binding]; other site 1205674002326 MoeB interaction surface [polypeptide binding]; other site 1205674002327 thiocarboxylated glycine; other site 1205674002328 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1205674002329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674002330 FeS/SAM binding site; other site 1205674002331 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205674002332 hypothetical protein; Provisional; Region: PRK11770 1205674002333 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205674002334 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205674002335 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205674002336 DNA-binding site [nucleotide binding]; DNA binding site 1205674002337 RNA-binding motif; other site 1205674002338 PE family; Region: PE; pfam00934 1205674002339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674002340 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674002341 active site 1205674002342 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1205674002343 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205674002344 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1205674002345 PPE family; Region: PPE; pfam00823 1205674002346 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002347 PPE family; Region: PPE; pfam00823 1205674002348 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002349 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205674002350 MarR family; Region: MarR; pfam01047 1205674002351 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205674002352 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205674002353 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205674002354 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1205674002355 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1205674002356 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1205674002357 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674002358 catalytic residue [active] 1205674002359 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1205674002360 Ferredoxin [Energy production and conversion]; Region: COG1146 1205674002361 4Fe-4S binding domain; Region: Fer4; pfam00037 1205674002362 ferredoxin-NADP+ reductase; Region: PLN02852 1205674002363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674002364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1205674002365 putative dimer interface [polypeptide binding]; other site 1205674002366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674002367 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1205674002368 putative catalytic site [active] 1205674002369 putative phosphate binding site [ion binding]; other site 1205674002370 putative metal binding site [ion binding]; other site 1205674002371 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1205674002372 dimer interface [polypeptide binding]; other site 1205674002373 Citrate synthase; Region: Citrate_synt; pfam00285 1205674002374 active site 1205674002375 citrylCoA binding site [chemical binding]; other site 1205674002376 oxalacetate/citrate binding site [chemical binding]; other site 1205674002377 coenzyme A binding site [chemical binding]; other site 1205674002378 catalytic triad [active] 1205674002379 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674002380 cyclase homology domain; Region: CHD; cd07302 1205674002381 nucleotidyl binding site; other site 1205674002382 metal binding site [ion binding]; metal-binding site 1205674002383 dimer interface [polypeptide binding]; other site 1205674002384 Predicted ATPase [General function prediction only]; Region: COG3903 1205674002385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674002386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674002387 DNA binding residues [nucleotide binding] 1205674002388 dimerization interface [polypeptide binding]; other site 1205674002389 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674002390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205674002391 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674002392 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674002393 AAA ATPase domain; Region: AAA_16; pfam13191 1205674002394 Predicted ATPase [General function prediction only]; Region: COG3903 1205674002395 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674002396 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674002397 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1205674002398 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1205674002399 dimer interface [polypeptide binding]; other site 1205674002400 active site 1205674002401 citrylCoA binding site [chemical binding]; other site 1205674002402 NADH binding [chemical binding]; other site 1205674002403 cationic pore residues; other site 1205674002404 oxalacetate/citrate binding site [chemical binding]; other site 1205674002405 coenzyme A binding site [chemical binding]; other site 1205674002406 catalytic triad [active] 1205674002407 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205674002408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674002409 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1205674002410 BON domain; Region: BON; pfam04972 1205674002411 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1205674002412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1205674002413 ligand binding site [chemical binding]; other site 1205674002414 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1205674002415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205674002416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674002417 dimerization interface [polypeptide binding]; other site 1205674002418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674002419 dimer interface [polypeptide binding]; other site 1205674002420 phosphorylation site [posttranslational modification] 1205674002421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674002422 Mg2+ binding site [ion binding]; other site 1205674002423 G-X-G motif; other site 1205674002424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674002425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674002426 active site 1205674002427 phosphorylation site [posttranslational modification] 1205674002428 intermolecular recognition site; other site 1205674002429 dimerization interface [polypeptide binding]; other site 1205674002430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674002431 DNA binding site [nucleotide binding] 1205674002432 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1205674002433 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1205674002434 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205674002435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674002436 substrate binding site [chemical binding]; other site 1205674002437 oxyanion hole (OAH) forming residues; other site 1205674002438 trimer interface [polypeptide binding]; other site 1205674002439 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205674002440 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1205674002441 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674002442 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674002443 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1205674002444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205674002445 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674002446 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205674002447 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002448 PPE family; Region: PPE; pfam00823 1205674002449 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002450 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002451 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002452 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002453 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002454 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002455 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002456 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002457 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002458 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002459 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002460 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674002461 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205674002462 hydrophobic ligand binding site; other site 1205674002463 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205674002464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674002465 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205674002466 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674002467 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1205674002468 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1205674002469 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1205674002470 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205674002471 active site 1205674002472 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002473 PPE family; Region: PPE; pfam00823 1205674002474 PE family; Region: PE; pfam00934 1205674002475 BCCT family transporter; Region: BCCT; pfam02028 1205674002476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1205674002477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674002478 Coenzyme A binding pocket [chemical binding]; other site 1205674002479 Phage capsid family; Region: Phage_capsid; pfam05065 1205674002480 Phage capsid family; Region: Phage_capsid; pfam05065 1205674002481 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1205674002482 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1205674002483 Phage Terminase; Region: Terminase_1; pfam03354 1205674002484 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674002485 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674002486 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1205674002487 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205674002488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674002489 non-specific DNA binding site [nucleotide binding]; other site 1205674002490 salt bridge; other site 1205674002491 sequence-specific DNA binding site [nucleotide binding]; other site 1205674002492 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1205674002493 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674002494 active site 1205674002495 DNA binding site [nucleotide binding] 1205674002496 Int/Topo IB signature motif; other site 1205674002497 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205674002498 MULE transposase domain; Region: MULE; pfam10551 1205674002499 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205674002500 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1205674002501 catalytic residues [active] 1205674002502 catalytic nucleophile [active] 1205674002503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674002504 Probable transposase; Region: OrfB_IS605; pfam01385 1205674002505 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1205674002506 putative active site pocket [active] 1205674002507 dimerization interface [polypeptide binding]; other site 1205674002508 putative catalytic residue [active] 1205674002509 Phage-related replication protein [General function prediction only]; Region: COG4195 1205674002510 manganese transport protein MntH; Reviewed; Region: PRK00701 1205674002511 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1205674002512 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205674002513 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1205674002514 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1205674002515 short chain dehydrogenase; Provisional; Region: PRK07814 1205674002516 classical (c) SDRs; Region: SDR_c; cd05233 1205674002517 NAD(P) binding site [chemical binding]; other site 1205674002518 active site 1205674002519 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1205674002520 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1205674002521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674002522 dimer interface [polypeptide binding]; other site 1205674002523 conserved gate region; other site 1205674002524 putative PBP binding loops; other site 1205674002525 ABC-ATPase subunit interface; other site 1205674002526 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1205674002527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674002528 dimer interface [polypeptide binding]; other site 1205674002529 conserved gate region; other site 1205674002530 putative PBP binding loops; other site 1205674002531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205674002532 ABC-ATPase subunit interface; other site 1205674002533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674002534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674002535 active site 1205674002536 ATP binding site [chemical binding]; other site 1205674002537 substrate binding site [chemical binding]; other site 1205674002538 activation loop (A-loop); other site 1205674002539 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205674002540 NHL repeat; Region: NHL; pfam01436 1205674002541 NHL repeat; Region: NHL; pfam01436 1205674002542 NHL repeat; Region: NHL; pfam01436 1205674002543 NHL repeat; Region: NHL; pfam01436 1205674002544 NHL repeat; Region: NHL; pfam01436 1205674002545 PBP superfamily domain; Region: PBP_like_2; cl17296 1205674002546 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1205674002547 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205674002548 Walker A/P-loop; other site 1205674002549 ATP binding site [chemical binding]; other site 1205674002550 Q-loop/lid; other site 1205674002551 ABC transporter signature motif; other site 1205674002552 Walker B; other site 1205674002553 D-loop; other site 1205674002554 H-loop/switch region; other site 1205674002555 PBP superfamily domain; Region: PBP_like_2; cl17296 1205674002556 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1205674002557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674002558 dimer interface [polypeptide binding]; other site 1205674002559 conserved gate region; other site 1205674002560 putative PBP binding loops; other site 1205674002561 ABC-ATPase subunit interface; other site 1205674002562 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1205674002563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674002564 dimer interface [polypeptide binding]; other site 1205674002565 conserved gate region; other site 1205674002566 putative PBP binding loops; other site 1205674002567 ABC-ATPase subunit interface; other site 1205674002568 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1205674002569 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1205674002570 putative DNA binding site [nucleotide binding]; other site 1205674002571 putative homodimer interface [polypeptide binding]; other site 1205674002572 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1205674002573 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1205674002574 nucleotide binding site [chemical binding]; other site 1205674002575 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1205674002576 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1205674002577 active site 1205674002578 DNA binding site [nucleotide binding] 1205674002579 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1205674002580 DNA binding site [nucleotide binding] 1205674002581 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1205674002582 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205674002583 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205674002584 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205674002585 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674002586 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205674002587 anti sigma factor interaction site; other site 1205674002588 regulatory phosphorylation site [posttranslational modification]; other site 1205674002589 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674002590 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1205674002591 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1205674002592 homodimer interface [polypeptide binding]; other site 1205674002593 active site 1205674002594 SAM binding site [chemical binding]; other site 1205674002595 PE family; Region: PE; pfam00934 1205674002596 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205674002597 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1205674002598 putative DNA binding site [nucleotide binding]; other site 1205674002599 catalytic residue [active] 1205674002600 putative H2TH interface [polypeptide binding]; other site 1205674002601 putative catalytic residues [active] 1205674002602 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205674002603 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205674002604 short chain dehydrogenase; Provisional; Region: PRK08251 1205674002605 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1205674002606 putative NAD(P) binding site [chemical binding]; other site 1205674002607 active site 1205674002608 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1205674002609 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1205674002610 active site 1205674002611 dimer interface [polypeptide binding]; other site 1205674002612 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1205674002613 dimer interface [polypeptide binding]; other site 1205674002614 active site 1205674002615 hypothetical protein; Provisional; Region: PRK07857 1205674002616 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1205674002617 Part of AAA domain; Region: AAA_19; pfam13245 1205674002618 Family description; Region: UvrD_C_2; pfam13538 1205674002619 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205674002620 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205674002621 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1205674002622 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1205674002623 CoA-ligase; Region: Ligase_CoA; pfam00549 1205674002624 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1205674002625 CoA binding domain; Region: CoA_binding; smart00881 1205674002626 CoA-ligase; Region: Ligase_CoA; pfam00549 1205674002627 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205674002628 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674002629 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674002630 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674002631 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1205674002632 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1205674002633 active site 1205674002634 substrate binding site [chemical binding]; other site 1205674002635 cosubstrate binding site; other site 1205674002636 catalytic site [active] 1205674002637 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1205674002638 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1205674002639 purine monophosphate binding site [chemical binding]; other site 1205674002640 dimer interface [polypeptide binding]; other site 1205674002641 putative catalytic residues [active] 1205674002642 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1205674002643 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1205674002644 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1205674002645 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1205674002646 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1205674002647 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205674002648 metal ion-dependent adhesion site (MIDAS); other site 1205674002649 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205674002650 homotetrameric interface [polypeptide binding]; other site 1205674002651 putative active site [active] 1205674002652 metal binding site [ion binding]; metal-binding site 1205674002653 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205674002654 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205674002655 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1205674002656 putative homodimer interface [polypeptide binding]; other site 1205674002657 putative homotetramer interface [polypeptide binding]; other site 1205674002658 allosteric switch controlling residues; other site 1205674002659 putative metal binding site [ion binding]; other site 1205674002660 putative homodimer-homodimer interface [polypeptide binding]; other site 1205674002661 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205674002662 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1205674002663 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674002664 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205674002665 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674002666 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674002667 enoyl-CoA hydratase; Provisional; Region: PRK07827 1205674002668 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674002669 substrate binding site [chemical binding]; other site 1205674002670 oxyanion hole (OAH) forming residues; other site 1205674002671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674002672 trimer interface [polypeptide binding]; other site 1205674002673 oxyanion hole (OAH) forming residues; other site 1205674002674 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674002675 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205674002676 active site 1205674002677 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205674002678 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205674002679 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205674002680 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205674002681 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205674002682 carboxyltransferase (CT) interaction site; other site 1205674002683 biotinylation site [posttranslational modification]; other site 1205674002684 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205674002685 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205674002686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674002687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674002688 active site 1205674002689 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1205674002690 PE family; Region: PE; pfam00934 1205674002691 PE family; Region: PE; pfam00934 1205674002692 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205674002693 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205674002694 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205674002695 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205674002696 PE family; Region: PE; pfam00934 1205674002697 NHL repeat; Region: NHL; pfam01436 1205674002698 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205674002699 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205674002700 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205674002701 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205674002702 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205674002703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674002704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674002705 active site 1205674002706 phosphorylation site [posttranslational modification] 1205674002707 intermolecular recognition site; other site 1205674002708 dimerization interface [polypeptide binding]; other site 1205674002709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674002710 DNA binding site [nucleotide binding] 1205674002711 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205674002712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674002713 dimerization interface [polypeptide binding]; other site 1205674002714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674002715 dimer interface [polypeptide binding]; other site 1205674002716 phosphorylation site [posttranslational modification] 1205674002717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674002718 ATP binding site [chemical binding]; other site 1205674002719 Mg2+ binding site [ion binding]; other site 1205674002720 G-X-G motif; other site 1205674002721 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1205674002722 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205674002723 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1205674002724 MPT binding site; other site 1205674002725 trimer interface [polypeptide binding]; other site 1205674002726 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1205674002727 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1205674002728 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205674002729 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205674002730 Walker A/P-loop; other site 1205674002731 ATP binding site [chemical binding]; other site 1205674002732 Q-loop/lid; other site 1205674002733 ABC transporter signature motif; other site 1205674002734 Walker B; other site 1205674002735 D-loop; other site 1205674002736 H-loop/switch region; other site 1205674002737 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1205674002738 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205674002739 FtsX-like permease family; Region: FtsX; pfam02687 1205674002740 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205674002741 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1205674002742 FtsX-like permease family; Region: FtsX; pfam02687 1205674002743 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1205674002744 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205674002745 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205674002746 substrate binding pocket [chemical binding]; other site 1205674002747 chain length determination region; other site 1205674002748 substrate-Mg2+ binding site; other site 1205674002749 catalytic residues [active] 1205674002750 aspartate-rich region 1; other site 1205674002751 active site lid residues [active] 1205674002752 aspartate-rich region 2; other site 1205674002753 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1205674002754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1205674002755 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1205674002756 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1205674002757 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1205674002758 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1205674002759 active site 1205674002760 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205674002761 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205674002762 dimer interface [polypeptide binding]; other site 1205674002763 putative functional site; other site 1205674002764 putative MPT binding site; other site 1205674002765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205674002766 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205674002767 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674002768 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674002769 ligand binding site [chemical binding]; other site 1205674002770 flexible hinge region; other site 1205674002771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205674002772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674002773 Coenzyme A binding pocket [chemical binding]; other site 1205674002774 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1205674002775 arginine deiminase; Provisional; Region: PRK01388 1205674002776 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1205674002777 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1205674002778 Predicted methyltransferases [General function prediction only]; Region: COG0313 1205674002779 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1205674002780 putative SAM binding site [chemical binding]; other site 1205674002781 putative homodimer interface [polypeptide binding]; other site 1205674002782 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1205674002783 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1205674002784 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1205674002785 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1205674002786 active site 1205674002787 HIGH motif; other site 1205674002788 KMSKS motif; other site 1205674002789 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1205674002790 tRNA binding surface [nucleotide binding]; other site 1205674002791 anticodon binding site; other site 1205674002792 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1205674002793 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1205674002794 active site 1205674002795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1205674002796 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205674002797 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205674002798 G5 domain; Region: G5; pfam07501 1205674002799 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205674002800 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1205674002801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674002802 S-adenosylmethionine binding site [chemical binding]; other site 1205674002803 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1205674002804 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1205674002805 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1205674002806 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674002807 acyl-activating enzyme (AAE) consensus motif; other site 1205674002808 AMP binding site [chemical binding]; other site 1205674002809 active site 1205674002810 CoA binding site [chemical binding]; other site 1205674002811 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1205674002812 putative active site [active] 1205674002813 catalytic residue [active] 1205674002814 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1205674002815 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1205674002816 5S rRNA interface [nucleotide binding]; other site 1205674002817 CTC domain interface [polypeptide binding]; other site 1205674002818 L16 interface [polypeptide binding]; other site 1205674002819 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205674002820 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1205674002821 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1205674002822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674002823 active site 1205674002824 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1205674002825 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1205674002826 Substrate binding site; other site 1205674002827 Mg++ binding site; other site 1205674002828 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1205674002829 active site 1205674002830 substrate binding site [chemical binding]; other site 1205674002831 CoA binding site [chemical binding]; other site 1205674002832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674002833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674002834 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1205674002835 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1205674002836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674002837 ATP binding site [chemical binding]; other site 1205674002838 putative Mg++ binding site [ion binding]; other site 1205674002839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674002840 nucleotide binding region [chemical binding]; other site 1205674002841 ATP-binding site [chemical binding]; other site 1205674002842 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1205674002843 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1205674002844 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1205674002845 homodimer interface [polypeptide binding]; other site 1205674002846 metal binding site [ion binding]; metal-binding site 1205674002847 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1205674002848 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1205674002849 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205674002850 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205674002851 enolase; Provisional; Region: eno; PRK00077 1205674002852 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1205674002853 dimer interface [polypeptide binding]; other site 1205674002854 metal binding site [ion binding]; metal-binding site 1205674002855 substrate binding pocket [chemical binding]; other site 1205674002856 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1205674002857 Septum formation initiator; Region: DivIC; pfam04977 1205674002858 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1205674002859 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1205674002860 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1205674002861 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1205674002862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674002863 active site 1205674002864 phosphorylation site [posttranslational modification] 1205674002865 intermolecular recognition site; other site 1205674002866 dimerization interface [polypeptide binding]; other site 1205674002867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674002868 DNA binding site [nucleotide binding] 1205674002869 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1205674002870 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1205674002871 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1205674002872 Ligand Binding Site [chemical binding]; other site 1205674002873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674002874 dimer interface [polypeptide binding]; other site 1205674002875 phosphorylation site [posttranslational modification] 1205674002876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674002877 ATP binding site [chemical binding]; other site 1205674002878 Mg2+ binding site [ion binding]; other site 1205674002879 G-X-G motif; other site 1205674002880 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1205674002881 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1205674002882 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674002883 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205674002884 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1205674002885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205674002886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674002887 dimer interface [polypeptide binding]; other site 1205674002888 phosphorylation site [posttranslational modification] 1205674002889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674002890 ATP binding site [chemical binding]; other site 1205674002891 Mg2+ binding site [ion binding]; other site 1205674002892 G-X-G motif; other site 1205674002893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674002894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674002895 active site 1205674002896 phosphorylation site [posttranslational modification] 1205674002897 intermolecular recognition site; other site 1205674002898 dimerization interface [polypeptide binding]; other site 1205674002899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674002900 DNA binding site [nucleotide binding] 1205674002901 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205674002902 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205674002903 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674002904 PPE family; Region: PPE; pfam00823 1205674002905 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674002906 PE family; Region: PE; pfam00934 1205674002907 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674002908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674002909 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1205674002910 Walker A motif; other site 1205674002911 ATP binding site [chemical binding]; other site 1205674002912 Walker B motif; other site 1205674002913 arginine finger; other site 1205674002914 Evidence 4 : Homologs of previously reported genes of unknown function 1205674002915 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 1205674002916 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205674002917 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1205674002918 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1205674002919 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1205674002920 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1205674002921 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1205674002922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674002923 ATP binding site [chemical binding]; other site 1205674002924 putative Mg++ binding site [ion binding]; other site 1205674002925 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1205674002926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674002927 nucleotide binding region [chemical binding]; other site 1205674002928 ATP-binding site [chemical binding]; other site 1205674002929 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1205674002930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674002931 non-specific DNA binding site [nucleotide binding]; other site 1205674002932 salt bridge; other site 1205674002933 sequence-specific DNA binding site [nucleotide binding]; other site 1205674002934 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205674002935 MarR family; Region: MarR_2; pfam12802 1205674002936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674002937 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674002938 NAD(P) binding site [chemical binding]; other site 1205674002939 active site 1205674002940 PIN domain; Region: PIN_3; pfam13470 1205674002941 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205674002942 Fic/DOC family; Region: Fic; pfam02661 1205674002943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674002944 DNA binding site [nucleotide binding] 1205674002945 Int/Topo IB signature motif; other site 1205674002946 active site 1205674002947 Domain of unknown function (DUF427); Region: DUF427; cl00998 1205674002948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205674002949 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674002950 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674002951 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205674002952 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1205674002953 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1205674002954 dimer interface [polypeptide binding]; other site 1205674002955 acyl-activating enzyme (AAE) consensus motif; other site 1205674002956 putative active site [active] 1205674002957 AMP binding site [chemical binding]; other site 1205674002958 putative CoA binding site [chemical binding]; other site 1205674002959 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1205674002960 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1205674002961 hydrophobic ligand binding site; other site 1205674002962 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1205674002963 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1205674002964 putative active site [active] 1205674002965 putative dimer interface [polypeptide binding]; other site 1205674002966 Patatin-like phospholipase; Region: Patatin; pfam01734 1205674002967 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205674002968 nucleophile elbow; other site 1205674002969 hypothetical protein; Provisional; Region: PRK10279 1205674002970 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1205674002971 active site 1205674002972 nucleophile elbow; other site 1205674002973 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1205674002974 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1205674002975 active site residue [active] 1205674002976 PE family; Region: PE; pfam00934 1205674002977 Predicted membrane protein [Function unknown]; Region: COG4425 1205674002978 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1205674002979 enoyl-CoA hydratase; Provisional; Region: PRK05862 1205674002980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674002981 substrate binding site [chemical binding]; other site 1205674002982 oxyanion hole (OAH) forming residues; other site 1205674002983 trimer interface [polypeptide binding]; other site 1205674002984 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1205674002985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674002986 substrate binding site [chemical binding]; other site 1205674002987 oxyanion hole (OAH) forming residues; other site 1205674002988 trimer interface [polypeptide binding]; other site 1205674002989 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1205674002990 Predicted membrane protein [Function unknown]; Region: COG4760 1205674002991 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205674002992 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1205674002993 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1205674002994 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205674002995 dimer interface [polypeptide binding]; other site 1205674002996 active site 1205674002997 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1205674002998 active site 1205674002999 catalytic triad [active] 1205674003000 oxyanion hole [active] 1205674003001 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205674003002 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205674003003 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1205674003004 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205674003005 dimer interface [polypeptide binding]; other site 1205674003006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674003007 catalytic residue [active] 1205674003008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1205674003009 RDD family; Region: RDD; pfam06271 1205674003010 cystathionine gamma-synthase; Provisional; Region: PRK07811 1205674003011 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205674003012 homodimer interface [polypeptide binding]; other site 1205674003013 substrate-cofactor binding pocket; other site 1205674003014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674003015 catalytic residue [active] 1205674003016 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1205674003017 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1205674003018 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205674003019 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1205674003020 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1205674003021 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1205674003022 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1205674003023 catalytic residues [active] 1205674003024 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1205674003025 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1205674003026 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1205674003027 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1205674003028 catalytic residue [active] 1205674003029 putative FPP diphosphate binding site; other site 1205674003030 putative FPP binding hydrophobic cleft; other site 1205674003031 dimer interface [polypeptide binding]; other site 1205674003032 putative IPP diphosphate binding site; other site 1205674003033 PE family; Region: PE; pfam00934 1205674003034 Evidence 4 : Homologs of previously reported genes of unknown function 1205674003035 pantothenate kinase; Provisional; Region: PRK05439 1205674003036 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1205674003037 ATP-binding site [chemical binding]; other site 1205674003038 CoA-binding site [chemical binding]; other site 1205674003039 Mg2+-binding site [ion binding]; other site 1205674003040 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1205674003041 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1205674003042 dimer interface [polypeptide binding]; other site 1205674003043 active site 1205674003044 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1205674003045 folate binding site [chemical binding]; other site 1205674003046 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1205674003047 dinuclear metal binding motif [ion binding]; other site 1205674003048 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1205674003049 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1205674003050 putative active site [active] 1205674003051 PhoH-like protein; Region: PhoH; pfam02562 1205674003052 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205674003053 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1205674003054 NodB motif; other site 1205674003055 active site 1205674003056 catalytic site [active] 1205674003057 metal binding site [ion binding]; metal-binding site 1205674003058 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1205674003059 Class II fumarases; Region: Fumarase_classII; cd01362 1205674003060 active site 1205674003061 tetramer interface [polypeptide binding]; other site 1205674003062 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1205674003063 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1205674003064 putative active site [active] 1205674003065 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1205674003066 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205674003067 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1205674003068 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205674003069 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205674003070 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205674003071 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205674003072 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1205674003073 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1205674003074 putative NAD(P) binding site [chemical binding]; other site 1205674003075 active site 1205674003076 putative substrate binding site [chemical binding]; other site 1205674003077 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1205674003078 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1205674003079 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1205674003080 generic binding surface II; other site 1205674003081 generic binding surface I; other site 1205674003082 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1205674003083 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1205674003084 GTP-binding protein YchF; Reviewed; Region: PRK09601 1205674003085 YchF GTPase; Region: YchF; cd01900 1205674003086 G1 box; other site 1205674003087 GTP/Mg2+ binding site [chemical binding]; other site 1205674003088 Switch I region; other site 1205674003089 G2 box; other site 1205674003090 Switch II region; other site 1205674003091 G3 box; other site 1205674003092 G4 box; other site 1205674003093 G5 box; other site 1205674003094 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1205674003095 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1205674003096 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1205674003097 putative active site [active] 1205674003098 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205674003099 cyclase homology domain; Region: CHD; cd07302 1205674003100 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674003101 cyclase homology domain; Region: CHD; cd07302 1205674003102 nucleotidyl binding site; other site 1205674003103 metal binding site [ion binding]; metal-binding site 1205674003104 dimer interface [polypeptide binding]; other site 1205674003105 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1205674003106 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205674003107 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205674003108 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205674003109 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1205674003110 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205674003111 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205674003112 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674003113 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674003114 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674003115 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1205674003116 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205674003117 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1205674003118 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674003119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674003120 active site 1205674003121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205674003122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674003123 non-specific DNA binding site [nucleotide binding]; other site 1205674003124 salt bridge; other site 1205674003125 sequence-specific DNA binding site [nucleotide binding]; other site 1205674003126 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1205674003127 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205674003128 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1205674003129 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1205674003130 citrate synthase; Provisional; Region: PRK14033 1205674003131 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1205674003132 oxalacetate binding site [chemical binding]; other site 1205674003133 citrylCoA binding site [chemical binding]; other site 1205674003134 coenzyme A binding site [chemical binding]; other site 1205674003135 catalytic triad [active] 1205674003136 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1205674003137 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1205674003138 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1205674003139 THF binding site; other site 1205674003140 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1205674003141 substrate binding site [chemical binding]; other site 1205674003142 THF binding site; other site 1205674003143 zinc-binding site [ion binding]; other site 1205674003144 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674003145 PPE family; Region: PPE; pfam00823 1205674003146 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674003147 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674003148 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205674003149 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1205674003150 catalytic residues [active] 1205674003151 catalytic nucleophile [active] 1205674003152 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205674003153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674003154 Probable transposase; Region: OrfB_IS605; pfam01385 1205674003155 Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 15525680; Product type e : enzyme 1205674003156 Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 15525680; Product type e : enzyme 1205674003157 Evidence 4 : Homologs of previously reported genes of unknown function 1205674003158 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1205674003159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1205674003160 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1205674003161 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205674003162 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674003163 substrate binding site [chemical binding]; other site 1205674003164 oxyanion hole (OAH) forming residues; other site 1205674003165 trimer interface [polypeptide binding]; other site 1205674003166 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205674003167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674003168 substrate binding site [chemical binding]; other site 1205674003169 oxyanion hole (OAH) forming residues; other site 1205674003170 trimer interface [polypeptide binding]; other site 1205674003171 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205674003172 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205674003173 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1205674003174 NAD binding site [chemical binding]; other site 1205674003175 homodimer interface [polypeptide binding]; other site 1205674003176 homotetramer interface [polypeptide binding]; other site 1205674003177 active site 1205674003178 MMPL family; Region: MMPL; pfam03176 1205674003179 MMPL family; Region: MMPL; pfam03176 1205674003180 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674003181 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674003182 active site 1205674003183 NAD-dependent deacetylase; Provisional; Region: PRK00481 1205674003184 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1205674003185 NAD+ binding site [chemical binding]; other site 1205674003186 substrate binding site [chemical binding]; other site 1205674003187 Zn binding site [ion binding]; other site 1205674003188 Predicted transcriptional regulators [Transcription]; Region: COG1725 1205674003189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674003190 DNA-binding site [nucleotide binding]; DNA binding site 1205674003191 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674003192 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1205674003193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1205674003194 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205674003195 uncharacterized HhH-GPD family protein; Region: TIGR03252 1205674003196 minor groove reading motif; other site 1205674003197 helix-hairpin-helix signature motif; other site 1205674003198 mannosyltransferase; Provisional; Region: pimE; PRK13375 1205674003199 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205674003200 aromatic arch; other site 1205674003201 DCoH dimer interaction site [polypeptide binding]; other site 1205674003202 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205674003203 DCoH tetramer interaction site [polypeptide binding]; other site 1205674003204 substrate binding site [chemical binding]; other site 1205674003205 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1205674003206 active site 1205674003207 8-oxo-dGMP binding site [chemical binding]; other site 1205674003208 nudix motif; other site 1205674003209 metal binding site [ion binding]; metal-binding site 1205674003210 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1205674003211 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1205674003212 [4Fe-4S] binding site [ion binding]; other site 1205674003213 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674003214 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674003215 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674003216 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1205674003217 molybdopterin cofactor binding site; other site 1205674003218 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1205674003219 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1205674003220 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1205674003221 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1205674003222 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1205674003223 G1 box; other site 1205674003224 putative GEF interaction site [polypeptide binding]; other site 1205674003225 GTP/Mg2+ binding site [chemical binding]; other site 1205674003226 Switch I region; other site 1205674003227 G2 box; other site 1205674003228 G3 box; other site 1205674003229 Switch II region; other site 1205674003230 G4 box; other site 1205674003231 G5 box; other site 1205674003232 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1205674003233 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1205674003234 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205674003235 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205674003236 PE family; Region: PE; pfam00934 1205674003237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674003238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674003239 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674003240 PPE family; Region: PPE; pfam00823 1205674003241 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674003242 PE family; Region: PE; pfam00934 1205674003243 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1205674003244 PE family; Region: PE; pfam00934 1205674003245 FO synthase; Reviewed; Region: fbiC; PRK09234 1205674003246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674003247 FeS/SAM binding site; other site 1205674003248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674003249 FeS/SAM binding site; other site 1205674003250 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1205674003251 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1205674003252 active site 1205674003253 FMN binding site [chemical binding]; other site 1205674003254 2,4-decadienoyl-CoA binding site; other site 1205674003255 catalytic residue [active] 1205674003256 4Fe-4S cluster binding site [ion binding]; other site 1205674003257 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1205674003258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674003259 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205674003260 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205674003261 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1205674003262 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1205674003263 4Fe-4S binding domain; Region: Fer4; pfam00037 1205674003264 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1205674003265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674003266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674003267 homodimer interface [polypeptide binding]; other site 1205674003268 catalytic residue [active] 1205674003269 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205674003270 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1205674003271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205674003272 ATP binding site [chemical binding]; other site 1205674003273 putative Mg++ binding site [ion binding]; other site 1205674003274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205674003275 nucleotide binding region [chemical binding]; other site 1205674003276 ATP-binding site [chemical binding]; other site 1205674003277 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674003278 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674003279 active site 1205674003280 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674003281 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674003282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674003283 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674003284 Enoylreductase; Region: PKS_ER; smart00829 1205674003285 NAD(P) binding site [chemical binding]; other site 1205674003286 KR domain; Region: KR; pfam08659 1205674003287 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205674003288 putative NADP binding site [chemical binding]; other site 1205674003289 active site 1205674003290 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674003291 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205674003292 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674003293 PE-PPE domain; Region: PE-PPE; pfam08237 1205674003294 acyl-CoA synthetase; Validated; Region: PRK05850 1205674003295 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674003296 acyl-activating enzyme (AAE) consensus motif; other site 1205674003297 active site 1205674003298 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205674003299 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205674003300 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1205674003301 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1205674003302 Glutamate binding site [chemical binding]; other site 1205674003303 NAD binding site [chemical binding]; other site 1205674003304 catalytic residues [active] 1205674003305 Proline dehydrogenase; Region: Pro_dh; cl03282 1205674003306 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1205674003307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674003308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674003309 DNA binding residues [nucleotide binding] 1205674003310 haloalkane dehalogenase; Provisional; Region: PRK03204 1205674003311 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205674003312 catalytic site [active] 1205674003313 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674003314 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1205674003315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205674003316 PGAP1-like protein; Region: PGAP1; pfam07819 1205674003317 acyl-CoA synthetase; Validated; Region: PRK07787 1205674003318 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674003319 acyl-activating enzyme (AAE) consensus motif; other site 1205674003320 AMP binding site [chemical binding]; other site 1205674003321 active site 1205674003322 CoA binding site [chemical binding]; other site 1205674003323 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205674003324 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205674003325 PE family; Region: PE; pfam00934 1205674003326 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674003327 PPE family; Region: PPE; pfam00823 1205674003328 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674003329 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205674003330 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205674003331 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205674003332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674003333 putative substrate translocation pore; other site 1205674003334 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1205674003335 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1205674003336 putative trimer interface [polypeptide binding]; other site 1205674003337 putative CoA binding site [chemical binding]; other site 1205674003338 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1205674003339 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1205674003340 metal binding site [ion binding]; metal-binding site 1205674003341 putative dimer interface [polypeptide binding]; other site 1205674003342 Predicted ATPase [General function prediction only]; Region: COG3899 1205674003343 TIGR00730 family protein; Region: TIGR00730 1205674003344 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1205674003345 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1205674003346 acyl-activating enzyme (AAE) consensus motif; other site 1205674003347 putative AMP binding site [chemical binding]; other site 1205674003348 putative active site [active] 1205674003349 putative CoA binding site [chemical binding]; other site 1205674003350 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1205674003351 dihydropteroate synthase; Region: DHPS; TIGR01496 1205674003352 substrate binding pocket [chemical binding]; other site 1205674003353 dimer interface [polypeptide binding]; other site 1205674003354 inhibitor binding site; inhibition site 1205674003355 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1205674003356 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205674003357 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205674003358 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1205674003359 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1205674003360 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1205674003361 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205674003362 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1205674003363 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1205674003364 ligand binding site; other site 1205674003365 oligomer interface; other site 1205674003366 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1205674003367 dimer interface [polypeptide binding]; other site 1205674003368 N-terminal domain interface [polypeptide binding]; other site 1205674003369 sulfate 1 binding site; other site 1205674003370 Evidence 4 : Homologs of previously reported genes of unknown function 1205674003371 PE family; Region: PE; pfam00934 1205674003372 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1205674003373 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1205674003374 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1205674003375 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1205674003376 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205674003377 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205674003378 Walker A/P-loop; other site 1205674003379 ATP binding site [chemical binding]; other site 1205674003380 Q-loop/lid; other site 1205674003381 ABC transporter signature motif; other site 1205674003382 Walker B; other site 1205674003383 D-loop; other site 1205674003384 H-loop/switch region; other site 1205674003385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674003386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674003387 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205674003388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674003389 S-adenosylmethionine binding site [chemical binding]; other site 1205674003390 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1205674003391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674003392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674003393 DNA binding residues [nucleotide binding] 1205674003394 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1205674003395 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205674003396 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205674003397 protein binding site [polypeptide binding]; other site 1205674003398 sec-independent translocase; Provisional; Region: PRK03100 1205674003399 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205674003400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674003401 active site 1205674003402 motif I; other site 1205674003403 motif II; other site 1205674003404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674003405 Predicted membrane protein [Function unknown]; Region: COG3428 1205674003406 Bacterial PH domain; Region: DUF304; pfam03703 1205674003407 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1205674003408 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1205674003409 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205674003410 putative active site [active] 1205674003411 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674003412 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674003413 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674003414 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674003415 Domain of unknown function DUF59; Region: DUF59; cl00941 1205674003416 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1205674003417 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1205674003418 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1205674003419 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205674003420 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205674003421 catalytic residue [active] 1205674003422 Predicted membrane protein [Function unknown]; Region: COG4420 1205674003423 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1205674003424 MgtE intracellular N domain; Region: MgtE_N; smart00924 1205674003425 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1205674003426 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1205674003427 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205674003428 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205674003429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674003430 dimer interface [polypeptide binding]; other site 1205674003431 conserved gate region; other site 1205674003432 putative PBP binding loops; other site 1205674003433 ABC-ATPase subunit interface; other site 1205674003434 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205674003435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674003436 dimer interface [polypeptide binding]; other site 1205674003437 conserved gate region; other site 1205674003438 ABC-ATPase subunit interface; other site 1205674003439 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205674003440 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205674003441 Walker A/P-loop; other site 1205674003442 ATP binding site [chemical binding]; other site 1205674003443 Q-loop/lid; other site 1205674003444 ABC transporter signature motif; other site 1205674003445 Walker B; other site 1205674003446 D-loop; other site 1205674003447 H-loop/switch region; other site 1205674003448 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1205674003449 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1205674003450 oligomer interface [polypeptide binding]; other site 1205674003451 metal binding site [ion binding]; metal-binding site 1205674003452 metal binding site [ion binding]; metal-binding site 1205674003453 putative Cl binding site [ion binding]; other site 1205674003454 basic sphincter; other site 1205674003455 hydrophobic gate; other site 1205674003456 periplasmic entrance; other site 1205674003457 malate dehydrogenase; Provisional; Region: PRK05442 1205674003458 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1205674003459 NAD(P) binding site [chemical binding]; other site 1205674003460 dimer interface [polypeptide binding]; other site 1205674003461 malate binding site [chemical binding]; other site 1205674003462 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674003463 PE family; Region: PE; pfam00934 1205674003464 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1205674003465 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1205674003466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674003467 NAD(P) binding site [chemical binding]; other site 1205674003468 active site 1205674003469 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205674003470 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205674003471 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1205674003472 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205674003473 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 1205674003474 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1205674003475 TPP-binding site [chemical binding]; other site 1205674003476 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1205674003477 dimer interface [polypeptide binding]; other site 1205674003478 PYR/PP interface [polypeptide binding]; other site 1205674003479 TPP binding site [chemical binding]; other site 1205674003480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674003481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674003482 putative substrate translocation pore; other site 1205674003483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674003484 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1205674003485 RNase_H superfamily; Region: RNase_H_2; pfam13482 1205674003486 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1205674003487 Part of AAA domain; Region: AAA_19; pfam13245 1205674003488 AAA domain; Region: AAA_12; pfam13087 1205674003489 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205674003490 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1205674003491 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205674003492 ATP binding site [chemical binding]; other site 1205674003493 Mg++ binding site [ion binding]; other site 1205674003494 motif III; other site 1205674003495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674003496 nucleotide binding region [chemical binding]; other site 1205674003497 ATP-binding site [chemical binding]; other site 1205674003498 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1205674003499 putative RNA binding site [nucleotide binding]; other site 1205674003500 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1205674003501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674003502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674003503 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674003504 Cytochrome P450; Region: p450; cl12078 1205674003505 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674003506 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205674003507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674003508 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205674003509 putative substrate translocation pore; other site 1205674003510 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1205674003511 Fe-S cluster binding site [ion binding]; other site 1205674003512 DNA binding site [nucleotide binding] 1205674003513 active site 1205674003514 hypothetical protein; Validated; Region: PRK05868 1205674003515 hypothetical protein; Provisional; Region: PRK07236 1205674003516 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205674003517 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205674003518 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1205674003519 HIT family signature motif; other site 1205674003520 catalytic residue [active] 1205674003521 amidase; Provisional; Region: PRK12470 1205674003522 Amidase; Region: Amidase; pfam01425 1205674003523 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674003524 cyclase homology domain; Region: CHD; cd07302 1205674003525 nucleotidyl binding site; other site 1205674003526 metal binding site [ion binding]; metal-binding site 1205674003527 dimer interface [polypeptide binding]; other site 1205674003528 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674003529 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674003530 active site 1205674003531 ATP binding site [chemical binding]; other site 1205674003532 substrate binding site [chemical binding]; other site 1205674003533 activation loop (A-loop); other site 1205674003534 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674003535 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674003536 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674003537 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674003538 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674003539 phosphopeptide binding site; other site 1205674003540 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674003541 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674003542 phosphopeptide binding site; other site 1205674003543 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1205674003544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205674003545 Walker A/P-loop; other site 1205674003546 ATP binding site [chemical binding]; other site 1205674003547 Q-loop/lid; other site 1205674003548 ABC transporter signature motif; other site 1205674003549 Walker B; other site 1205674003550 D-loop; other site 1205674003551 H-loop/switch region; other site 1205674003552 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1205674003553 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205674003554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674003555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674003556 active site 1205674003557 ATP binding site [chemical binding]; other site 1205674003558 substrate binding site [chemical binding]; other site 1205674003559 activation loop (A-loop); other site 1205674003560 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205674003561 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205674003562 DNA binding site [nucleotide binding] 1205674003563 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674003564 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674003565 phosphopeptide binding site; other site 1205674003566 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1205674003567 putative active site [active] 1205674003568 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1205674003569 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205674003570 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674003571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205674003572 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1205674003573 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205674003574 Walker A/P-loop; other site 1205674003575 ATP binding site [chemical binding]; other site 1205674003576 Q-loop/lid; other site 1205674003577 ABC transporter signature motif; other site 1205674003578 Walker B; other site 1205674003579 D-loop; other site 1205674003580 H-loop/switch region; other site 1205674003581 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205674003582 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205674003583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674003584 Walker A/P-loop; other site 1205674003585 ATP binding site [chemical binding]; other site 1205674003586 Q-loop/lid; other site 1205674003587 ABC transporter signature motif; other site 1205674003588 Walker B; other site 1205674003589 D-loop; other site 1205674003590 H-loop/switch region; other site 1205674003591 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205674003592 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205674003593 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674003594 catalytic core [active] 1205674003595 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1205674003596 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1205674003597 active site 1205674003598 metal binding site [ion binding]; metal-binding site 1205674003599 DNA binding site [nucleotide binding] 1205674003600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674003601 Walker A/P-loop; other site 1205674003602 ATP binding site [chemical binding]; other site 1205674003603 choline dehydrogenase; Validated; Region: PRK02106 1205674003604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674003605 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205674003606 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205674003607 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205674003608 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1205674003609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205674003610 Walker A/P-loop; other site 1205674003611 ATP binding site [chemical binding]; other site 1205674003612 Q-loop/lid; other site 1205674003613 ABC transporter signature motif; other site 1205674003614 Walker B; other site 1205674003615 D-loop; other site 1205674003616 H-loop/switch region; other site 1205674003617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205674003618 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205674003619 Walker A/P-loop; other site 1205674003620 ATP binding site [chemical binding]; other site 1205674003621 Q-loop/lid; other site 1205674003622 ABC transporter signature motif; other site 1205674003623 Walker B; other site 1205674003624 D-loop; other site 1205674003625 H-loop/switch region; other site 1205674003626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1205674003627 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205674003628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674003629 dimer interface [polypeptide binding]; other site 1205674003630 conserved gate region; other site 1205674003631 putative PBP binding loops; other site 1205674003632 ABC-ATPase subunit interface; other site 1205674003633 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1205674003634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674003635 dimer interface [polypeptide binding]; other site 1205674003636 conserved gate region; other site 1205674003637 putative PBP binding loops; other site 1205674003638 ABC-ATPase subunit interface; other site 1205674003639 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1205674003640 active site clefts [active] 1205674003641 zinc binding site [ion binding]; other site 1205674003642 dimer interface [polypeptide binding]; other site 1205674003643 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10537214, 11271494, 11929522, 11929527, 12368446, 12657046, 16573683; Product type pe : putative enzyme 1205674003644 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1205674003645 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1205674003646 CysD dimerization site [polypeptide binding]; other site 1205674003647 G1 box; other site 1205674003648 putative GEF interaction site [polypeptide binding]; other site 1205674003649 GTP/Mg2+ binding site [chemical binding]; other site 1205674003650 Switch I region; other site 1205674003651 G2 box; other site 1205674003652 G3 box; other site 1205674003653 Switch II region; other site 1205674003654 G4 box; other site 1205674003655 G5 box; other site 1205674003656 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1205674003657 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1205674003658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674003659 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1205674003660 Walker A/P-loop; other site 1205674003661 ligand-binding site [chemical binding]; other site 1205674003662 ATP binding site [chemical binding]; other site 1205674003663 Rrf2 family protein; Region: rrf2_super; TIGR00738 1205674003664 Transcriptional regulator; Region: Rrf2; pfam02082 1205674003665 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205674003666 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1205674003667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205674003668 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205674003669 Putative esterase; Region: Esterase; pfam00756 1205674003670 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1205674003671 Predicted membrane protein [Function unknown]; Region: COG4325 1205674003672 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1205674003673 Evidence 4 : Homologs of previously reported genes of unknown function 1205674003674 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674003675 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205674003676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674003677 Probable transposase; Region: OrfB_IS605; pfam01385 1205674003678 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1205674003679 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205674003680 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1205674003681 catalytic residues [active] 1205674003682 catalytic nucleophile [active] 1205674003683 hypothetical protein; Provisional; Region: PRK13696 1205674003684 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1205674003685 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674003686 active site 1205674003687 DNA binding site [nucleotide binding] 1205674003688 Int/Topo IB signature motif; other site 1205674003689 Helix-turn-helix domain; Region: HTH_17; pfam12728 1205674003690 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1205674003691 active site 1205674003692 metal binding site [ion binding]; metal-binding site 1205674003693 interdomain interaction site; other site 1205674003694 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1205674003695 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1205674003696 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1205674003697 Phage capsid family; Region: Phage_capsid; pfam05065 1205674003698 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1205674003699 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1205674003700 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1205674003701 active site 1205674003702 HIGH motif; other site 1205674003703 KMSK motif region; other site 1205674003704 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1205674003705 tRNA binding surface [nucleotide binding]; other site 1205674003706 anticodon binding site; other site 1205674003707 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1205674003708 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1205674003709 active site 1205674003710 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205674003711 substrate binding site [chemical binding]; other site 1205674003712 catalytic residues [active] 1205674003713 dimer interface [polypeptide binding]; other site 1205674003714 homoserine dehydrogenase; Provisional; Region: PRK06349 1205674003715 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1205674003716 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1205674003717 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1205674003718 threonine synthase; Reviewed; Region: PRK06721 1205674003719 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1205674003720 homodimer interface [polypeptide binding]; other site 1205674003721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674003722 catalytic residue [active] 1205674003723 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1205674003724 transcription termination factor Rho; Provisional; Region: PRK12678 1205674003725 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1205674003726 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205674003727 RNA binding site [nucleotide binding]; other site 1205674003728 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1205674003729 multimer interface [polypeptide binding]; other site 1205674003730 Walker A motif; other site 1205674003731 ATP binding site [chemical binding]; other site 1205674003732 Walker B motif; other site 1205674003733 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1205674003734 peptide chain release factor 1; Region: prfA; TIGR00019 1205674003735 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205674003736 RF-1 domain; Region: RF-1; pfam00472 1205674003737 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1205674003738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674003739 S-adenosylmethionine binding site [chemical binding]; other site 1205674003740 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1205674003741 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1205674003742 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1205674003743 Mg++ binding site [ion binding]; other site 1205674003744 putative catalytic motif [active] 1205674003745 substrate binding site [chemical binding]; other site 1205674003746 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1205674003747 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1205674003748 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1205674003749 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1205674003750 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1205674003751 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1205674003752 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1205674003753 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1205674003754 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1205674003755 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205674003756 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205674003757 Walker A motif; other site 1205674003758 ATP binding site [chemical binding]; other site 1205674003759 Walker B motif; other site 1205674003760 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205674003761 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1205674003762 core domain interface [polypeptide binding]; other site 1205674003763 delta subunit interface [polypeptide binding]; other site 1205674003764 epsilon subunit interface [polypeptide binding]; other site 1205674003765 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1205674003766 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205674003767 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1205674003768 alpha subunit interaction interface [polypeptide binding]; other site 1205674003769 Walker A motif; other site 1205674003770 ATP binding site [chemical binding]; other site 1205674003771 Walker B motif; other site 1205674003772 inhibitor binding site; inhibition site 1205674003773 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205674003774 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1205674003775 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1205674003776 gamma subunit interface [polypeptide binding]; other site 1205674003777 epsilon subunit interface [polypeptide binding]; other site 1205674003778 LBP interface [polypeptide binding]; other site 1205674003779 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1205674003780 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1205674003781 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1205674003782 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1205674003783 hinge; other site 1205674003784 active site 1205674003785 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1205674003786 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1205674003787 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205674003788 DNA binding site [nucleotide binding] 1205674003789 active site 1205674003790 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1205674003791 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1205674003792 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1205674003793 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1205674003794 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205674003795 minor groove reading motif; other site 1205674003796 helix-hairpin-helix signature motif; other site 1205674003797 substrate binding pocket [chemical binding]; other site 1205674003798 active site 1205674003799 HAMP domain; Region: HAMP; pfam00672 1205674003800 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674003801 cyclase homology domain; Region: CHD; cd07302 1205674003802 nucleotidyl binding site; other site 1205674003803 metal binding site [ion binding]; metal-binding site 1205674003804 dimer interface [polypeptide binding]; other site 1205674003805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674003806 dimerization interface [polypeptide binding]; other site 1205674003807 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674003808 cyclase homology domain; Region: CHD; cd07302 1205674003809 nucleotidyl binding site; other site 1205674003810 metal binding site [ion binding]; metal-binding site 1205674003811 dimer interface [polypeptide binding]; other site 1205674003812 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1205674003813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674003814 dimerization interface [polypeptide binding]; other site 1205674003815 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674003816 cyclase homology domain; Region: CHD; cd07302 1205674003817 nucleotidyl binding site; other site 1205674003818 metal binding site [ion binding]; metal-binding site 1205674003819 dimer interface [polypeptide binding]; other site 1205674003820 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1205674003821 hypothetical protein; Provisional; Region: PRK03298 1205674003822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674003823 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1205674003824 dimer interface [polypeptide binding]; other site 1205674003825 substrate binding site [chemical binding]; other site 1205674003826 metal binding site [ion binding]; metal-binding site 1205674003827 putative acyltransferase; Provisional; Region: PRK05790 1205674003828 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205674003829 dimer interface [polypeptide binding]; other site 1205674003830 active site 1205674003831 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1205674003832 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1205674003833 Evidence 5 : No homology to any previously reported sequences 1205674003834 Evidence 4 : Homologs of previously reported genes of unknown function 1205674003835 Evidence 4 : Homologs of previously reported genes of unknown function 1205674003836 Evidence 5 : No homology to any previously reported sequences 1205674003837 glycogen branching enzyme; Provisional; Region: PRK05402 1205674003838 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1205674003839 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1205674003840 active site 1205674003841 catalytic site [active] 1205674003842 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1205674003843 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1205674003844 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1205674003845 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1205674003846 active site 1205674003847 homodimer interface [polypeptide binding]; other site 1205674003848 catalytic site [active] 1205674003849 acceptor binding site [chemical binding]; other site 1205674003850 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1205674003851 putative homodimer interface [polypeptide binding]; other site 1205674003852 putative active site pocket [active] 1205674003853 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1205674003854 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674003855 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674003856 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1205674003857 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1205674003858 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1205674003859 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1205674003860 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1205674003861 active site 1205674003862 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1205674003863 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1205674003864 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1205674003865 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1205674003866 putative active site pocket [active] 1205674003867 cleavage site 1205674003868 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1205674003869 MPN+ (JAMM) motif; other site 1205674003870 Zinc-binding site [ion binding]; other site 1205674003871 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205674003872 MoaE interaction surface [polypeptide binding]; other site 1205674003873 MoeB interaction surface [polypeptide binding]; other site 1205674003874 thiocarboxylated glycine; other site 1205674003875 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205674003876 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205674003877 dimer interface [polypeptide binding]; other site 1205674003878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674003879 catalytic residue [active] 1205674003880 Rhomboid family; Region: Rhomboid; cl11446 1205674003881 glutamate racemase; Provisional; Region: PRK00865 1205674003882 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205674003883 ribonuclease PH; Reviewed; Region: rph; PRK00173 1205674003884 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1205674003885 hexamer interface [polypeptide binding]; other site 1205674003886 active site 1205674003887 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1205674003888 active site 1205674003889 dimerization interface [polypeptide binding]; other site 1205674003890 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1205674003891 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1205674003892 acyl carrier protein; Validated; Region: PRK05883 1205674003893 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1205674003894 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674003895 acyl-activating enzyme (AAE) consensus motif; other site 1205674003896 active site 1205674003897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674003898 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674003899 active site 1205674003900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1205674003901 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1205674003902 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205674003903 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205674003904 FAD binding pocket [chemical binding]; other site 1205674003905 FAD binding motif [chemical binding]; other site 1205674003906 phosphate binding motif [ion binding]; other site 1205674003907 NAD binding pocket [chemical binding]; other site 1205674003908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674003909 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205674003910 Walker A/P-loop; other site 1205674003911 ATP binding site [chemical binding]; other site 1205674003912 Q-loop/lid; other site 1205674003913 ABC transporter signature motif; other site 1205674003914 Walker B; other site 1205674003915 D-loop; other site 1205674003916 H-loop/switch region; other site 1205674003917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674003918 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205674003919 Walker A/P-loop; other site 1205674003920 ATP binding site [chemical binding]; other site 1205674003921 Q-loop/lid; other site 1205674003922 ABC transporter signature motif; other site 1205674003923 Walker B; other site 1205674003924 D-loop; other site 1205674003925 H-loop/switch region; other site 1205674003926 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205674003927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674003928 NAD(P) binding site [chemical binding]; other site 1205674003929 active site 1205674003930 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1205674003931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674003932 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205674003933 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205674003934 GAF domain; Region: GAF; pfam01590 1205674003935 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1205674003936 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1205674003937 metal binding site [ion binding]; metal-binding site 1205674003938 active site 1205674003939 I-site; other site 1205674003940 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205674003941 hypothetical protein; Provisional; Region: PRK07877 1205674003942 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1205674003943 ATP binding site [chemical binding]; other site 1205674003944 substrate interface [chemical binding]; other site 1205674003945 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205674003946 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205674003947 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674003948 cyclase homology domain; Region: CHD; cd07302 1205674003949 dimer interface [polypeptide binding]; other site 1205674003950 nucleotidyl binding site; other site 1205674003951 metal binding site [ion binding]; metal-binding site 1205674003952 AAA ATPase domain; Region: AAA_16; pfam13191 1205674003953 Predicted ATPase [General function prediction only]; Region: COG3903 1205674003954 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674003955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674003956 DNA binding residues [nucleotide binding] 1205674003957 dimerization interface [polypeptide binding]; other site 1205674003958 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674003959 cyclase homology domain; Region: CHD; cd07302 1205674003960 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1205674003961 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674003962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674003963 PPE family; Region: PPE; pfam00823 1205674003964 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674003965 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674003966 PAS fold; Region: PAS_4; pfam08448 1205674003967 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205674003968 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1205674003969 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205674003970 anti sigma factor interaction site; other site 1205674003971 regulatory phosphorylation site [posttranslational modification]; other site 1205674003972 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205674003973 anti sigma factor interaction site; other site 1205674003974 regulatory phosphorylation site [posttranslational modification]; other site 1205674003975 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205674003976 synthetase active site [active] 1205674003977 NTP binding site [chemical binding]; other site 1205674003978 metal binding site [ion binding]; metal-binding site 1205674003979 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674003980 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674003981 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205674003982 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1205674003983 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205674003984 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205674003985 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205674003986 malonyl-CoA binding site [chemical binding]; other site 1205674003987 dimer interface [polypeptide binding]; other site 1205674003988 active site 1205674003989 product binding site; other site 1205674003990 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205674003991 uncharacterized domain; Region: TIGR00702 1205674003992 YcaO-like family; Region: YcaO; pfam02624 1205674003993 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1205674003994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674003995 S-adenosylmethionine binding site [chemical binding]; other site 1205674003996 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674003997 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1205674003998 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1205674003999 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1205674004000 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1205674004001 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205674004002 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205674004003 dihydroorotase; Validated; Region: pyrC; PRK09357 1205674004004 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205674004005 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1205674004006 active site 1205674004007 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1205674004008 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1205674004009 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1205674004010 catalytic site [active] 1205674004011 subunit interface [polypeptide binding]; other site 1205674004012 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1205674004013 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205674004014 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205674004015 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1205674004016 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205674004017 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205674004018 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1205674004019 IMP binding site; other site 1205674004020 dimer interface [polypeptide binding]; other site 1205674004021 interdomain contacts; other site 1205674004022 partial ornithine binding site; other site 1205674004023 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1205674004024 active site 1205674004025 dimer interface [polypeptide binding]; other site 1205674004026 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674004027 PPE family; Region: PPE; pfam00823 1205674004028 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1205674004029 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1205674004030 catalytic site [active] 1205674004031 G-X2-G-X-G-K; other site 1205674004032 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1205674004033 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1205674004034 Flavoprotein; Region: Flavoprotein; pfam02441 1205674004035 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1205674004036 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1205674004037 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1205674004038 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1205674004039 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1205674004040 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674004041 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205674004042 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674004043 Cytochrome P450; Region: p450; cl12078 1205674004044 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205674004045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205674004046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205674004047 PE family; Region: PE; pfam00934 1205674004048 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205674004049 oligomeric interface; other site 1205674004050 putative active site [active] 1205674004051 homodimer interface [polypeptide binding]; other site 1205674004052 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674004053 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205674004054 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674004055 substrate binding pocket [chemical binding]; other site 1205674004056 Predicted membrane protein [Function unknown]; Region: COG3714 1205674004057 primosome assembly protein PriA; Provisional; Region: PRK14873 1205674004058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004059 S-adenosylmethionine binding site [chemical binding]; other site 1205674004060 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205674004061 MarR family; Region: MarR; pfam01047 1205674004062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004063 S-adenosylmethionine binding site [chemical binding]; other site 1205674004064 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1205674004065 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1205674004066 putative active site [active] 1205674004067 substrate binding site [chemical binding]; other site 1205674004068 putative cosubstrate binding site; other site 1205674004069 catalytic site [active] 1205674004070 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1205674004071 substrate binding site [chemical binding]; other site 1205674004072 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1205674004073 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1205674004074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004075 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1205674004076 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1205674004077 substrate binding site [chemical binding]; other site 1205674004078 hexamer interface [polypeptide binding]; other site 1205674004079 metal binding site [ion binding]; metal-binding site 1205674004080 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1205674004081 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1205674004082 catalytic motif [active] 1205674004083 Zn binding site [ion binding]; other site 1205674004084 RibD C-terminal domain; Region: RibD_C; pfam01872 1205674004085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674004086 putative substrate translocation pore; other site 1205674004087 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205674004088 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1205674004089 Lumazine binding domain; Region: Lum_binding; pfam00677 1205674004090 Lumazine binding domain; Region: Lum_binding; pfam00677 1205674004091 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205674004092 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1205674004093 dimer interface [polypeptide binding]; other site 1205674004094 active site 1205674004095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205674004096 substrate binding site [chemical binding]; other site 1205674004097 catalytic residue [active] 1205674004098 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1205674004099 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1205674004100 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1205674004101 dimerization interface [polypeptide binding]; other site 1205674004102 active site 1205674004103 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1205674004104 homopentamer interface [polypeptide binding]; other site 1205674004105 active site 1205674004106 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205674004107 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674004108 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1205674004109 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1205674004110 putative sugar binding sites [chemical binding]; other site 1205674004111 Q-X-W motif; other site 1205674004112 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1205674004113 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205674004114 GIY-YIG motif/motif A; other site 1205674004115 active site 1205674004116 catalytic site [active] 1205674004117 putative DNA binding site [nucleotide binding]; other site 1205674004118 metal binding site [ion binding]; metal-binding site 1205674004119 UvrB/uvrC motif; Region: UVR; pfam02151 1205674004120 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1205674004121 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205674004122 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1205674004123 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1205674004124 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1205674004125 phosphate binding site [ion binding]; other site 1205674004126 putative substrate binding pocket [chemical binding]; other site 1205674004127 dimer interface [polypeptide binding]; other site 1205674004128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1205674004129 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1205674004130 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674004131 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674004132 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205674004133 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674004134 substrate binding pocket [chemical binding]; other site 1205674004135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205674004136 acyl-CoA synthetase; Provisional; Region: PRK13382 1205674004137 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205674004138 acyl-activating enzyme (AAE) consensus motif; other site 1205674004139 putative AMP binding site [chemical binding]; other site 1205674004140 putative active site [active] 1205674004141 putative CoA binding site [chemical binding]; other site 1205674004142 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674004143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205674004144 putative acyl-acceptor binding pocket; other site 1205674004145 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205674004146 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205674004147 PE family; Region: PE; pfam00934 1205674004148 PE-PPE domain; Region: PE-PPE; pfam08237 1205674004149 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1205674004150 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205674004151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674004152 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205674004153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205674004154 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205674004155 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1205674004156 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1205674004157 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1205674004158 Phosphoglycerate kinase; Region: PGK; pfam00162 1205674004159 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1205674004160 substrate binding site [chemical binding]; other site 1205674004161 hinge regions; other site 1205674004162 ADP binding site [chemical binding]; other site 1205674004163 catalytic site [active] 1205674004164 triosephosphate isomerase; Provisional; Region: PRK14567 1205674004165 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1205674004166 substrate binding site [chemical binding]; other site 1205674004167 dimer interface [polypeptide binding]; other site 1205674004168 catalytic triad [active] 1205674004169 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205674004170 Preprotein translocase SecG subunit; Region: SecG; cl09123 1205674004171 PE family; Region: PE; pfam00934 1205674004172 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1205674004173 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1205674004174 molybdopterin cofactor binding site [chemical binding]; other site 1205674004175 substrate binding site [chemical binding]; other site 1205674004176 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1205674004177 molybdopterin cofactor binding site; other site 1205674004178 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205674004179 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1205674004180 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1205674004181 putative active site [active] 1205674004182 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1205674004183 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1205674004184 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1205674004185 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205674004186 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205674004187 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1205674004188 putative active site [active] 1205674004189 transaldolase; Provisional; Region: PRK03903 1205674004190 catalytic residue [active] 1205674004191 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1205674004192 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1205674004193 TPP-binding site [chemical binding]; other site 1205674004194 dimer interface [polypeptide binding]; other site 1205674004195 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205674004196 PYR/PP interface [polypeptide binding]; other site 1205674004197 dimer interface [polypeptide binding]; other site 1205674004198 TPP binding site [chemical binding]; other site 1205674004199 Evidence 4 : Homologs of previously reported genes of unknown function 1205674004200 Evidence 4 : Homologs of previously reported genes of unknown function 1205674004201 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1205674004202 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205674004203 Evidence 4 : Homologs of previously reported genes of unknown function 1205674004204 Evidence 5 : No homology to any previously reported sequences 1205674004205 Evidence 4 : Homologs of previously reported genes of unknown function 1205674004206 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205674004207 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205674004208 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1205674004209 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1205674004210 NADP binding site [chemical binding]; other site 1205674004211 dimer interface [polypeptide binding]; other site 1205674004212 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1205674004213 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1205674004214 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205674004215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205674004216 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205674004217 Walker A/P-loop; other site 1205674004218 ATP binding site [chemical binding]; other site 1205674004219 Q-loop/lid; other site 1205674004220 ABC transporter signature motif; other site 1205674004221 Walker B; other site 1205674004222 D-loop; other site 1205674004223 H-loop/switch region; other site 1205674004224 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1205674004225 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205674004226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674004227 dimerization interface [polypeptide binding]; other site 1205674004228 putative DNA binding site [nucleotide binding]; other site 1205674004229 putative Zn2+ binding site [ion binding]; other site 1205674004230 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205674004231 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205674004232 protein-splicing catalytic site; other site 1205674004233 thioester formation/cholesterol transfer; other site 1205674004234 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1205674004235 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205674004236 protein-splicing catalytic site; other site 1205674004237 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205674004238 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205674004239 protein-splicing catalytic site; other site 1205674004240 thioester formation/cholesterol transfer; other site 1205674004241 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1205674004242 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1205674004243 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205674004244 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1205674004245 FeS assembly protein SufD; Region: sufD; TIGR01981 1205674004246 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1205674004247 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1205674004248 Walker A/P-loop; other site 1205674004249 ATP binding site [chemical binding]; other site 1205674004250 Q-loop/lid; other site 1205674004251 ABC transporter signature motif; other site 1205674004252 Walker B; other site 1205674004253 D-loop; other site 1205674004254 H-loop/switch region; other site 1205674004255 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205674004256 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1205674004257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674004258 catalytic residue [active] 1205674004259 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1205674004260 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1205674004261 trimerization site [polypeptide binding]; other site 1205674004262 active site 1205674004263 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1205674004264 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1205674004265 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1205674004266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674004267 active site 1205674004268 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1205674004269 PE family; Region: PE; pfam00934 1205674004270 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1205674004271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674004272 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674004273 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674004274 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205674004275 catalytic residues [active] 1205674004276 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205674004277 catalytic residues [active] 1205674004278 enoyl-CoA hydratase; Provisional; Region: PRK05864 1205674004279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674004280 substrate binding site [chemical binding]; other site 1205674004281 oxyanion hole (OAH) forming residues; other site 1205674004282 trimer interface [polypeptide binding]; other site 1205674004283 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205674004284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674004285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674004286 Walker A/P-loop; other site 1205674004287 ATP binding site [chemical binding]; other site 1205674004288 Q-loop/lid; other site 1205674004289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674004290 ABC transporter signature motif; other site 1205674004291 Walker B; other site 1205674004292 D-loop; other site 1205674004293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674004294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674004295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674004296 aconitate hydratase; Validated; Region: PRK09277 1205674004297 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1205674004298 substrate binding site [chemical binding]; other site 1205674004299 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1205674004300 ligand binding site [chemical binding]; other site 1205674004301 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1205674004302 substrate binding site [chemical binding]; other site 1205674004303 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205674004304 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205674004305 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205674004306 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205674004307 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205674004308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674004309 Walker A motif; other site 1205674004310 ATP binding site [chemical binding]; other site 1205674004311 Walker B motif; other site 1205674004312 arginine finger; other site 1205674004313 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205674004314 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205674004315 hypothetical protein; Provisional; Region: PRK13685 1205674004316 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1205674004317 metal ion-dependent adhesion site (MIDAS); other site 1205674004318 Evidence 4 : Homologs of previously reported genes of unknown function 1205674004319 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1205674004320 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1205674004321 NAD(P) binding site [chemical binding]; other site 1205674004322 homotetramer interface [polypeptide binding]; other site 1205674004323 homodimer interface [polypeptide binding]; other site 1205674004324 active site 1205674004325 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1205674004326 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1205674004327 NAD binding site [chemical binding]; other site 1205674004328 homotetramer interface [polypeptide binding]; other site 1205674004329 homodimer interface [polypeptide binding]; other site 1205674004330 substrate binding site [chemical binding]; other site 1205674004331 active site 1205674004332 ferrochelatase; Reviewed; Region: hemH; PRK00035 1205674004333 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1205674004334 C-terminal domain interface [polypeptide binding]; other site 1205674004335 active site 1205674004336 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1205674004337 active site 1205674004338 N-terminal domain interface [polypeptide binding]; other site 1205674004339 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1205674004340 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205674004341 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1205674004342 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205674004343 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205674004344 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1205674004345 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1205674004346 heterodimer interface [polypeptide binding]; other site 1205674004347 substrate interaction site [chemical binding]; other site 1205674004348 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1205674004349 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1205674004350 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1205674004351 active site 1205674004352 substrate binding site [chemical binding]; other site 1205674004353 coenzyme B12 binding site [chemical binding]; other site 1205674004354 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1205674004355 B12 binding site [chemical binding]; other site 1205674004356 cobalt ligand [ion binding]; other site 1205674004357 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205674004358 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1205674004359 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1205674004360 Walker A; other site 1205674004361 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674004362 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674004363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004364 S-adenosylmethionine binding site [chemical binding]; other site 1205674004365 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1205674004366 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1205674004367 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1205674004368 Ligand binding site; other site 1205674004369 Putative Catalytic site; other site 1205674004370 DXD motif; other site 1205674004371 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1205674004372 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1205674004373 active site 1205674004374 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1205674004375 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205674004376 inhibitor-cofactor binding pocket; inhibition site 1205674004377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674004378 catalytic residue [active] 1205674004379 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1205674004380 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1205674004381 putative trimer interface [polypeptide binding]; other site 1205674004382 putative CoA binding site [chemical binding]; other site 1205674004383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004384 S-adenosylmethionine binding site [chemical binding]; other site 1205674004385 WbqC-like protein family; Region: WbqC; pfam08889 1205674004386 Evidence 4 : Homologs of previously reported genes of unknown function 1205674004387 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 1205674004388 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1205674004389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674004390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674004391 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205674004392 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1205674004393 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1205674004394 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1205674004395 NADP-binding site; other site 1205674004396 homotetramer interface [polypeptide binding]; other site 1205674004397 substrate binding site [chemical binding]; other site 1205674004398 homodimer interface [polypeptide binding]; other site 1205674004399 active site 1205674004400 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1205674004401 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1205674004402 NADP binding site [chemical binding]; other site 1205674004403 active site 1205674004404 putative substrate binding site [chemical binding]; other site 1205674004405 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205674004406 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1205674004407 metal-binding site 1205674004408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004409 S-adenosylmethionine binding site [chemical binding]; other site 1205674004410 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205674004411 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205674004412 active site 1205674004413 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205674004414 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205674004415 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1205674004416 active site 1205674004417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205674004418 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205674004419 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205674004420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205674004421 active site 1205674004422 acyl-CoA synthetase; Validated; Region: PRK05850 1205674004423 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674004424 acyl-activating enzyme (AAE) consensus motif; other site 1205674004425 active site 1205674004426 Transport protein; Region: actII; TIGR00833 1205674004427 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205674004428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004429 S-adenosylmethionine binding site [chemical binding]; other site 1205674004430 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205674004431 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205674004432 homodimer interface [polypeptide binding]; other site 1205674004433 active site 1205674004434 TDP-binding site; other site 1205674004435 acceptor substrate-binding pocket; other site 1205674004436 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205674004437 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205674004438 Probable Catalytic site; other site 1205674004439 metal-binding site 1205674004440 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205674004441 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205674004442 homodimer interface [polypeptide binding]; other site 1205674004443 active site 1205674004444 TDP-binding site; other site 1205674004445 acceptor substrate-binding pocket; other site 1205674004446 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674004447 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674004448 active site 1205674004449 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205674004450 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674004451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674004452 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674004453 Enoylreductase; Region: PKS_ER; smart00829 1205674004454 NAD(P) binding site [chemical binding]; other site 1205674004455 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205674004456 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674004457 putative NADP binding site [chemical binding]; other site 1205674004458 active site 1205674004459 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674004460 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12368446, 12657046, 16573683; Product type pe : putative enzyme 1205674004461 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12368446, 12657046, 16573683 1205674004462 acyl-CoA synthetase; Validated; Region: PRK05850 1205674004463 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674004464 acyl-activating enzyme (AAE) consensus motif; other site 1205674004465 active site 1205674004466 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205674004467 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205674004468 NAD(P) binding site [chemical binding]; other site 1205674004469 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205674004470 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205674004471 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205674004472 CoenzymeA binding site [chemical binding]; other site 1205674004473 subunit interaction site [polypeptide binding]; other site 1205674004474 PHB binding site; other site 1205674004475 Nitronate monooxygenase; Region: NMO; pfam03060 1205674004476 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205674004477 FMN binding site [chemical binding]; other site 1205674004478 substrate binding site [chemical binding]; other site 1205674004479 putative catalytic residue [active] 1205674004480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674004481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674004482 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1205674004483 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205674004484 HIGH motif; other site 1205674004485 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205674004486 active site 1205674004487 KMSKS motif; other site 1205674004488 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1205674004489 tRNA binding surface [nucleotide binding]; other site 1205674004490 anticodon binding site; other site 1205674004491 DNA polymerase IV; Provisional; Region: PRK03348 1205674004492 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1205674004493 active site 1205674004494 DNA binding site [nucleotide binding] 1205674004495 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1205674004496 active site 1205674004497 homodimer interface [polypeptide binding]; other site 1205674004498 homotetramer interface [polypeptide binding]; other site 1205674004499 lipoprotein signal peptidase; Provisional; Region: PRK14764 1205674004500 lipoprotein signal peptidase; Provisional; Region: PRK14787 1205674004501 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1205674004502 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1205674004503 active site 1205674004504 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1205674004505 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1205674004506 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1205674004507 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1205674004508 apolar tunnel; other site 1205674004509 heme binding site [chemical binding]; other site 1205674004510 dimerization interface [polypeptide binding]; other site 1205674004511 short chain dehydrogenase; Provisional; Region: PRK05866 1205674004512 classical (c) SDRs; Region: SDR_c; cd05233 1205674004513 NAD(P) binding site [chemical binding]; other site 1205674004514 active site 1205674004515 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205674004516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674004517 NAD(P) binding site [chemical binding]; other site 1205674004518 active site 1205674004519 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205674004520 hydrophobic ligand binding site; other site 1205674004521 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1205674004522 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1205674004523 active site 1205674004524 PHP Thumb interface [polypeptide binding]; other site 1205674004525 metal binding site [ion binding]; metal-binding site 1205674004526 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1205674004527 generic binding surface II; other site 1205674004528 generic binding surface I; other site 1205674004529 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674004530 PPE family; Region: PPE; pfam00823 1205674004531 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674004532 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674004533 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205674004534 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205674004535 acyl-activating enzyme (AAE) consensus motif; other site 1205674004536 putative AMP binding site [chemical binding]; other site 1205674004537 putative active site [active] 1205674004538 putative CoA binding site [chemical binding]; other site 1205674004539 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1205674004540 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1205674004541 putative acyl-acceptor binding pocket; other site 1205674004542 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1205674004543 L-aspartate oxidase; Provisional; Region: PRK06175 1205674004544 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205674004545 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1205674004546 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1205674004547 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1205674004548 D-subunit interface [polypeptide binding]; other site 1205674004549 Iron-sulfur protein interface; other site 1205674004550 proximal quinone binding site [chemical binding]; other site 1205674004551 distal quinone binding site [chemical binding]; other site 1205674004552 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1205674004553 Iron-sulfur protein interface; other site 1205674004554 proximal quinone binding site [chemical binding]; other site 1205674004555 C-subunit interface; other site 1205674004556 distal quinone binding site; other site 1205674004557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674004558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674004559 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205674004560 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674004561 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205674004562 threonine dehydratase; Validated; Region: PRK08639 1205674004563 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1205674004564 tetramer interface [polypeptide binding]; other site 1205674004565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674004566 catalytic residue [active] 1205674004567 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1205674004568 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205674004569 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205674004570 putative active site [active] 1205674004571 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1205674004572 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1205674004573 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1205674004574 catalytic site [active] 1205674004575 active site 1205674004576 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1205674004577 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1205674004578 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1205674004579 active site 1205674004580 catalytic site [active] 1205674004581 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1205674004582 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1205674004583 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1205674004584 active site 1205674004585 catalytic site [active] 1205674004586 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205674004587 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205674004588 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205674004589 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1205674004590 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205674004591 inhibitor-cofactor binding pocket; inhibition site 1205674004592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674004593 catalytic residue [active] 1205674004594 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1205674004595 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1205674004596 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674004597 catalytic residue [active] 1205674004598 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1205674004599 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1205674004600 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674004601 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674004602 active site 1205674004603 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674004604 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674004605 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674004606 biotin synthase; Validated; Region: PRK06256 1205674004607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674004608 FeS/SAM binding site; other site 1205674004609 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1205674004610 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1205674004611 Secretory lipase; Region: LIP; pfam03583 1205674004612 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1205674004613 nudix motif; other site 1205674004614 quinolinate synthetase; Provisional; Region: PRK09375 1205674004615 L-aspartate oxidase; Provisional; Region: PRK07804 1205674004616 L-aspartate oxidase; Provisional; Region: PRK06175 1205674004617 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205674004618 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1205674004619 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1205674004620 dimerization interface [polypeptide binding]; other site 1205674004621 active site 1205674004622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004623 S-adenosylmethionine binding site [chemical binding]; other site 1205674004624 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1205674004625 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1205674004626 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1205674004627 NAD binding site [chemical binding]; other site 1205674004628 dimerization interface [polypeptide binding]; other site 1205674004629 product binding site; other site 1205674004630 substrate binding site [chemical binding]; other site 1205674004631 zinc binding site [ion binding]; other site 1205674004632 catalytic residues [active] 1205674004633 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1205674004634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674004635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674004636 homodimer interface [polypeptide binding]; other site 1205674004637 catalytic residue [active] 1205674004638 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1205674004639 4-fold oligomerization interface [polypeptide binding]; other site 1205674004640 putative active site pocket [active] 1205674004641 metal binding residues [ion binding]; metal-binding site 1205674004642 3-fold/trimer interface [polypeptide binding]; other site 1205674004643 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1205674004644 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1205674004645 putative active site [active] 1205674004646 oxyanion strand; other site 1205674004647 catalytic triad [active] 1205674004648 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1205674004649 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205674004650 catalytic residues [active] 1205674004651 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205674004652 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1205674004653 active site 1205674004654 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1205674004655 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205674004656 substrate binding site [chemical binding]; other site 1205674004657 glutamase interaction surface [polypeptide binding]; other site 1205674004658 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1205674004659 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1205674004660 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1205674004661 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205674004662 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1205674004663 catalytic triad [active] 1205674004664 anthranilate synthase component I; Provisional; Region: PRK13571 1205674004665 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1205674004666 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205674004667 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1205674004668 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1205674004669 active site 1205674004670 ribulose/triose binding site [chemical binding]; other site 1205674004671 phosphate binding site [ion binding]; other site 1205674004672 substrate (anthranilate) binding pocket [chemical binding]; other site 1205674004673 product (indole) binding pocket [chemical binding]; other site 1205674004674 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1205674004675 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1205674004676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674004677 catalytic residue [active] 1205674004678 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1205674004679 substrate binding site [chemical binding]; other site 1205674004680 active site 1205674004681 catalytic residues [active] 1205674004682 heterodimer interface [polypeptide binding]; other site 1205674004683 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1205674004684 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1205674004685 TM2 domain; Region: TM2; pfam05154 1205674004686 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1205674004687 pyruvate kinase; Provisional; Region: PRK06247 1205674004688 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1205674004689 domain interfaces; other site 1205674004690 active site 1205674004691 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1205674004692 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205674004693 active site 1205674004694 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1205674004695 catalytic triad [active] 1205674004696 dimer interface [polypeptide binding]; other site 1205674004697 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1205674004698 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1205674004699 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1205674004700 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1205674004701 Walker A/P-loop; other site 1205674004702 ATP binding site [chemical binding]; other site 1205674004703 Q-loop/lid; other site 1205674004704 ABC transporter signature motif; other site 1205674004705 Walker B; other site 1205674004706 D-loop; other site 1205674004707 H-loop/switch region; other site 1205674004708 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1205674004709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674004710 Walker A/P-loop; other site 1205674004711 ATP binding site [chemical binding]; other site 1205674004712 Q-loop/lid; other site 1205674004713 ABC transporter signature motif; other site 1205674004714 Walker B; other site 1205674004715 D-loop; other site 1205674004716 H-loop/switch region; other site 1205674004717 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1205674004718 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1205674004719 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1205674004720 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1205674004721 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1205674004722 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1205674004723 cyclase homology domain; Region: CHD; cd07302 1205674004724 nucleotidyl binding site; other site 1205674004725 metal binding site [ion binding]; metal-binding site 1205674004726 dimer interface [polypeptide binding]; other site 1205674004727 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1205674004728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674004729 active site 1205674004730 phosphorylation site [posttranslational modification] 1205674004731 intermolecular recognition site; other site 1205674004732 dimerization interface [polypeptide binding]; other site 1205674004733 ANTAR domain; Region: ANTAR; pfam03861 1205674004734 lipid-transfer protein; Provisional; Region: PRK06059 1205674004735 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205674004736 active site 1205674004737 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205674004738 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1205674004739 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205674004740 DNA polymerase I; Provisional; Region: PRK05755 1205674004741 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1205674004742 active site 1205674004743 metal binding site 1 [ion binding]; metal-binding site 1205674004744 putative 5' ssDNA interaction site; other site 1205674004745 metal binding site 3; metal-binding site 1205674004746 metal binding site 2 [ion binding]; metal-binding site 1205674004747 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1205674004748 putative DNA binding site [nucleotide binding]; other site 1205674004749 putative metal binding site [ion binding]; other site 1205674004750 3'-5' exonuclease; Region: 35EXOc; smart00474 1205674004751 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1205674004752 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1205674004753 active site 1205674004754 DNA binding site [nucleotide binding] 1205674004755 catalytic site [active] 1205674004756 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1205674004757 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1205674004758 RNA binding site [nucleotide binding]; other site 1205674004759 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1205674004760 RNA binding site [nucleotide binding]; other site 1205674004761 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205674004762 RNA binding site [nucleotide binding]; other site 1205674004763 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1205674004764 RNA binding site [nucleotide binding]; other site 1205674004765 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1205674004766 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1205674004767 CoA-binding site [chemical binding]; other site 1205674004768 ATP-binding [chemical binding]; other site 1205674004769 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1205674004770 Protein of unknown function (DUF402); Region: DUF402; cl00979 1205674004771 excinuclease ABC subunit B; Provisional; Region: PRK05298 1205674004772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674004773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674004774 nucleotide binding region [chemical binding]; other site 1205674004775 ATP-binding site [chemical binding]; other site 1205674004776 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1205674004777 UvrB/uvrC motif; Region: UVR; pfam02151 1205674004778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674004779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674004780 putative substrate translocation pore; other site 1205674004781 Predicted membrane protein [Function unknown]; Region: COG5305 1205674004782 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674004783 Ligand Binding Site [chemical binding]; other site 1205674004784 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205674004785 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1205674004786 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205674004787 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205674004788 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1205674004789 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1205674004790 Predicted esterase [General function prediction only]; Region: COG0627 1205674004791 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1205674004792 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1205674004793 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1205674004794 dimer interface [polypeptide binding]; other site 1205674004795 putative anticodon binding site; other site 1205674004796 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205674004797 motif 1; other site 1205674004798 dimer interface [polypeptide binding]; other site 1205674004799 active site 1205674004800 motif 2; other site 1205674004801 motif 3; other site 1205674004802 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1205674004803 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1205674004804 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1205674004805 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1205674004806 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1205674004807 23S rRNA binding site [nucleotide binding]; other site 1205674004808 L21 binding site [polypeptide binding]; other site 1205674004809 L13 binding site [polypeptide binding]; other site 1205674004810 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205674004811 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205674004812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205674004813 PE family; Region: PE; pfam00934 1205674004814 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674004815 cyclase homology domain; Region: CHD; cd07302 1205674004816 nucleotidyl binding site; other site 1205674004817 metal binding site [ion binding]; metal-binding site 1205674004818 dimer interface [polypeptide binding]; other site 1205674004819 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1205674004820 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1205674004821 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1205674004822 dimer interface [polypeptide binding]; other site 1205674004823 motif 1; other site 1205674004824 active site 1205674004825 motif 2; other site 1205674004826 motif 3; other site 1205674004827 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1205674004828 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1205674004829 putative tRNA-binding site [nucleotide binding]; other site 1205674004830 B3/4 domain; Region: B3_4; pfam03483 1205674004831 tRNA synthetase B5 domain; Region: B5; smart00874 1205674004832 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1205674004833 dimer interface [polypeptide binding]; other site 1205674004834 motif 1; other site 1205674004835 motif 3; other site 1205674004836 motif 2; other site 1205674004837 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1205674004838 PE family; Region: PE; pfam00934 1205674004839 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1205674004840 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205674004841 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1205674004842 heterotetramer interface [polypeptide binding]; other site 1205674004843 active site pocket [active] 1205674004844 cleavage site 1205674004845 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1205674004846 feedback inhibition sensing region; other site 1205674004847 homohexameric interface [polypeptide binding]; other site 1205674004848 nucleotide binding site [chemical binding]; other site 1205674004849 N-acetyl-L-glutamate binding site [chemical binding]; other site 1205674004850 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1205674004851 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205674004852 inhibitor-cofactor binding pocket; inhibition site 1205674004853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674004854 catalytic residue [active] 1205674004855 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1205674004856 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205674004857 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205674004858 arginine repressor; Provisional; Region: PRK03341 1205674004859 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1205674004860 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1205674004861 argininosuccinate synthase; Provisional; Region: PRK13820 1205674004862 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1205674004863 ANP binding site [chemical binding]; other site 1205674004864 Substrate Binding Site II [chemical binding]; other site 1205674004865 Substrate Binding Site I [chemical binding]; other site 1205674004866 argininosuccinate lyase; Provisional; Region: PRK00855 1205674004867 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1205674004868 active sites [active] 1205674004869 tetramer interface [polypeptide binding]; other site 1205674004870 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205674004871 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205674004872 malonyl-CoA binding site [chemical binding]; other site 1205674004873 dimer interface [polypeptide binding]; other site 1205674004874 active site 1205674004875 product binding site; other site 1205674004876 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674004877 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674004878 active site 1205674004879 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674004880 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674004881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674004882 Enoylreductase; Region: PKS_ER; smart00829 1205674004883 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674004884 NAD(P) binding site [chemical binding]; other site 1205674004885 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205674004886 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674004887 putative NADP binding site [chemical binding]; other site 1205674004888 active site 1205674004889 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674004890 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674004891 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674004892 active site 1205674004893 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674004894 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674004895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674004896 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674004897 Enoylreductase; Region: PKS_ER; smart00829 1205674004898 NAD(P) binding site [chemical binding]; other site 1205674004899 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205674004900 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674004901 putative NADP binding site [chemical binding]; other site 1205674004902 active site 1205674004903 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674004904 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205674004905 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674004906 active site 1205674004907 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205674004908 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674004909 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674004910 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205674004911 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205674004912 malonyl-CoA binding site [chemical binding]; other site 1205674004913 dimer interface [polypeptide binding]; other site 1205674004914 active site 1205674004915 product binding site; other site 1205674004916 Cytochrome P450; Region: p450; cl12078 1205674004917 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674004918 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205674004919 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674004920 ABC transporter; Region: ABC_tran_2; pfam12848 1205674004921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674004922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205674004923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674004924 putative substrate translocation pore; other site 1205674004925 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205674004926 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205674004927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674004928 dimerization interface [polypeptide binding]; other site 1205674004929 putative DNA binding site [nucleotide binding]; other site 1205674004930 putative Zn2+ binding site [ion binding]; other site 1205674004931 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1205674004932 active site residue [active] 1205674004933 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674004934 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674004935 ligand binding site [chemical binding]; other site 1205674004936 flexible hinge region; other site 1205674004937 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1205674004938 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1205674004939 putative catalytic residues [active] 1205674004940 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1205674004941 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205674004942 catalytic residues [active] 1205674004943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674004944 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205674004945 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205674004946 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1205674004947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205674004948 substrate binding pocket [chemical binding]; other site 1205674004949 membrane-bound complex binding site; other site 1205674004950 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1205674004951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674004952 FeS/SAM binding site; other site 1205674004953 DivIVA protein; Region: DivIVA; pfam05103 1205674004954 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205674004955 acyl-CoA synthetase; Validated; Region: PRK07868 1205674004956 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1205674004957 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674004958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674004959 acyl-activating enzyme (AAE) consensus motif; other site 1205674004960 AMP binding site [chemical binding]; other site 1205674004961 active site 1205674004962 CoA binding site [chemical binding]; other site 1205674004963 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1205674004964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674004965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674004966 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205674004967 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205674004968 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205674004969 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1205674004970 Walker A/P-loop; other site 1205674004971 ATP binding site [chemical binding]; other site 1205674004972 Q-loop/lid; other site 1205674004973 ABC transporter signature motif; other site 1205674004974 Walker B; other site 1205674004975 D-loop; other site 1205674004976 H-loop/switch region; other site 1205674004977 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1205674004978 active site 1205674004979 DNA binding site [nucleotide binding] 1205674004980 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1205674004981 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1205674004982 active site 1205674004983 HIGH motif; other site 1205674004984 dimer interface [polypeptide binding]; other site 1205674004985 KMSKS motif; other site 1205674004986 S4 RNA-binding domain; Region: S4; smart00363 1205674004987 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674004988 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205674004989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674004990 active site 1205674004991 motif I; other site 1205674004992 motif II; other site 1205674004993 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205674004994 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1205674004995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205674004996 RNA binding surface [nucleotide binding]; other site 1205674004997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674004998 S-adenosylmethionine binding site [chemical binding]; other site 1205674004999 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1205674005000 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1205674005001 DNA repair protein RecN; Region: recN; TIGR00634 1205674005002 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205674005003 Walker A/P-loop; other site 1205674005004 ATP binding site [chemical binding]; other site 1205674005005 Q-loop/lid; other site 1205674005006 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205674005007 ABC transporter signature motif; other site 1205674005008 Walker B; other site 1205674005009 D-loop; other site 1205674005010 H-loop/switch region; other site 1205674005011 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1205674005012 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1205674005013 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1205674005014 CTP synthetase; Validated; Region: pyrG; PRK05380 1205674005015 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1205674005016 Catalytic site [active] 1205674005017 active site 1205674005018 UTP binding site [chemical binding]; other site 1205674005019 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1205674005020 active site 1205674005021 putative oxyanion hole; other site 1205674005022 catalytic triad [active] 1205674005023 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1205674005024 dimer interface [polypeptide binding]; other site 1205674005025 ADP-ribose binding site [chemical binding]; other site 1205674005026 active site 1205674005027 nudix motif; other site 1205674005028 metal binding site [ion binding]; metal-binding site 1205674005029 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1205674005030 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674005031 active site 1205674005032 DNA binding site [nucleotide binding] 1205674005033 Int/Topo IB signature motif; other site 1205674005034 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674005035 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674005036 active site 1205674005037 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205674005038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674005039 S-adenosylmethionine binding site [chemical binding]; other site 1205674005040 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1205674005041 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005042 PPE family; Region: PPE; pfam00823 1205674005043 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674005044 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005045 PPE family; Region: PPE; pfam00823 1205674005046 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674005047 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205674005048 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205674005049 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205674005050 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205674005051 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674005052 P-loop; other site 1205674005053 Magnesium ion binding site [ion binding]; other site 1205674005054 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674005055 Magnesium ion binding site [ion binding]; other site 1205674005056 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1205674005057 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1205674005058 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1205674005059 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1205674005060 active site 1205674005061 cytidylate kinase; Provisional; Region: cmk; PRK00023 1205674005062 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1205674005063 CMP-binding site; other site 1205674005064 The sites determining sugar specificity; other site 1205674005065 GTP-binding protein Der; Reviewed; Region: PRK03003 1205674005066 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1205674005067 GTP/Mg2+ binding site [chemical binding]; other site 1205674005068 Switch I region; other site 1205674005069 G2 box; other site 1205674005070 Switch II region; other site 1205674005071 G3 box; other site 1205674005072 G4 box; other site 1205674005073 G5 box; other site 1205674005074 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1205674005075 G1 box; other site 1205674005076 GTP/Mg2+ binding site [chemical binding]; other site 1205674005077 Switch I region; other site 1205674005078 G2 box; other site 1205674005079 G3 box; other site 1205674005080 Switch II region; other site 1205674005081 G4 box; other site 1205674005082 G5 box; other site 1205674005083 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1205674005084 classical (c) SDRs; Region: SDR_c; cd05233 1205674005085 NAD(P) binding site [chemical binding]; other site 1205674005086 active site 1205674005087 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1205674005088 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205674005089 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205674005090 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1205674005091 Cupin domain; Region: Cupin_2; cl17218 1205674005092 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1205674005093 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205674005094 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205674005095 putative switch regulator; other site 1205674005096 non-specific DNA interactions [nucleotide binding]; other site 1205674005097 DNA binding site [nucleotide binding] 1205674005098 sequence specific DNA binding site [nucleotide binding]; other site 1205674005099 putative cAMP binding site [chemical binding]; other site 1205674005100 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205674005101 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205674005102 putative active site [active] 1205674005103 homotetrameric interface [polypeptide binding]; other site 1205674005104 metal binding site [ion binding]; metal-binding site 1205674005105 biotin carboxylase-like protein; Validated; Region: PRK06524 1205674005106 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1205674005107 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674005108 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674005109 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205674005110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674005111 dimerization interface [polypeptide binding]; other site 1205674005112 putative DNA binding site [nucleotide binding]; other site 1205674005113 putative Zn2+ binding site [ion binding]; other site 1205674005114 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205674005115 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674005116 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674005117 Berberine and berberine like; Region: BBE; pfam08031 1205674005118 TIGR03086 family protein; Region: TIGR03086 1205674005119 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205674005120 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674005121 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674005122 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674005123 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674005124 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1205674005125 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1205674005126 NAD(P) binding site [chemical binding]; other site 1205674005127 catalytic residues [active] 1205674005128 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1205674005129 putative catalytic residue [active] 1205674005130 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205674005131 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1205674005132 gating phenylalanine in ion channel; other site 1205674005133 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1205674005134 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1205674005135 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1205674005136 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1205674005137 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1205674005138 [4Fe-4S] binding site [ion binding]; other site 1205674005139 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674005140 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674005141 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674005142 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1205674005143 molybdopterin cofactor binding site; other site 1205674005144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674005145 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1205674005146 putative substrate translocation pore; other site 1205674005147 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1205674005148 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205674005149 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1205674005150 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205674005151 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205674005152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205674005153 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1205674005154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674005155 active site 1205674005156 ATP binding site [chemical binding]; other site 1205674005157 substrate binding site [chemical binding]; other site 1205674005158 activation loop (A-loop); other site 1205674005159 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1205674005160 Thioredoxin; Region: Thioredoxin_4; cl17273 1205674005161 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1205674005162 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1205674005163 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1205674005164 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1205674005165 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1205674005166 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 1205674005167 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674005168 catalytic loop [active] 1205674005169 iron binding site [ion binding]; other site 1205674005170 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1205674005171 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1205674005172 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1205674005173 active site 1205674005174 metal binding site [ion binding]; metal-binding site 1205674005175 nudix motif; other site 1205674005176 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674005177 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205674005178 active site 1205674005179 ATP binding site [chemical binding]; other site 1205674005180 substrate binding site [chemical binding]; other site 1205674005181 activation loop (A-loop); other site 1205674005182 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674005183 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674005184 phosphopeptide binding site; other site 1205674005185 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674005186 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674005187 phosphopeptide binding site; other site 1205674005188 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1205674005189 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1205674005190 Walker A/P-loop; other site 1205674005191 ATP binding site [chemical binding]; other site 1205674005192 Q-loop/lid; other site 1205674005193 ABC transporter signature motif; other site 1205674005194 Walker B; other site 1205674005195 D-loop; other site 1205674005196 H-loop/switch region; other site 1205674005197 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205674005198 acyl-CoA synthetase; Provisional; Region: PRK13388 1205674005199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674005200 acyl-activating enzyme (AAE) consensus motif; other site 1205674005201 AMP binding site [chemical binding]; other site 1205674005202 active site 1205674005203 CoA binding site [chemical binding]; other site 1205674005204 hypothetical protein; Provisional; Region: PRK06185 1205674005205 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205674005206 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205674005207 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1205674005208 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005209 PPE family; Region: PPE; pfam00823 1205674005210 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1205674005211 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205674005212 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205674005213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205674005214 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1205674005215 sulfite oxidase; Provisional; Region: PLN00177 1205674005216 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1205674005217 Moco binding site; other site 1205674005218 metal coordination site [ion binding]; other site 1205674005219 dimerization interface [polypeptide binding]; other site 1205674005220 Transport protein; Region: actII; TIGR00833 1205674005221 Cutinase; Region: Cutinase; pfam01083 1205674005222 PE family; Region: PE; pfam00934 1205674005223 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674005224 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674005225 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1205674005226 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1205674005227 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674005228 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674005229 active site 1205674005230 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674005231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674005232 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674005233 Integrase core domain; Region: rve; pfam00665 1205674005234 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205674005235 putative homotetramer interface [polypeptide binding]; other site 1205674005236 putative homodimer interface [polypeptide binding]; other site 1205674005237 putative allosteric switch controlling residues; other site 1205674005238 putative metal binding site [ion binding]; other site 1205674005239 putative homodimer-homodimer interface [polypeptide binding]; other site 1205674005240 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1205674005241 PE family; Region: PE; pfam00934 1205674005242 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205674005243 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1205674005244 dimer interface [polypeptide binding]; other site 1205674005245 active site 1205674005246 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205674005247 substrate binding site [chemical binding]; other site 1205674005248 catalytic residue [active] 1205674005249 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1205674005250 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205674005251 metal binding site [ion binding]; metal-binding site 1205674005252 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1205674005253 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674005254 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205674005255 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1205674005256 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205674005257 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205674005258 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205674005259 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674005260 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674005261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674005262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674005263 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674005264 Cytochrome P450; Region: p450; cl12078 1205674005265 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1205674005266 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1205674005267 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1205674005268 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205674005269 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205674005270 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674005271 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205674005272 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674005273 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674005274 Cytochrome P450; Region: p450; cl12078 1205674005275 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205674005276 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005277 PPE family; Region: PPE; pfam00823 1205674005278 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674005279 PE family; Region: PE; pfam00934 1205674005280 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005281 PPE family; Region: PPE; pfam00823 1205674005282 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674005283 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005284 PPE family; Region: PPE; pfam00823 1205674005285 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674005286 PE family; Region: PE; pfam00934 1205674005287 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205674005288 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205674005289 EspG family; Region: ESX-1_EspG; pfam14011 1205674005290 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205674005291 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205674005292 catalytic residues [active] 1205674005293 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205674005294 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1205674005295 active site 1205674005296 catalytic residues [active] 1205674005297 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205674005298 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205674005299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674005300 Walker A motif; other site 1205674005301 ATP binding site [chemical binding]; other site 1205674005302 Walker B motif; other site 1205674005303 arginine finger; other site 1205674005304 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005305 PPE family; Region: PPE; pfam00823 1205674005306 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005307 PE-PPE domain; Region: PE-PPE; pfam08237 1205674005308 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005309 PPE family; Region: PPE; pfam00823 1205674005310 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005311 PPE family; Region: PPE; pfam00823 1205674005312 PE family; Region: PE; pfam00934 1205674005313 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674005314 PE family; Region: PE; pfam00934 1205674005315 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005316 PPE family; Region: PPE; pfam00823 1205674005317 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005318 PPE family; Region: PPE; pfam00823 1205674005319 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005320 PPE family; Region: PPE; pfam00823 1205674005321 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674005322 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674005323 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1205674005324 MgtC family; Region: MgtC; pfam02308 1205674005325 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205674005326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674005327 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1205674005328 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1205674005329 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1205674005330 hypothetical protein; Validated; Region: PRK07121 1205674005331 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1205674005332 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1205674005333 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1205674005334 hypothetical protein; Provisional; Region: PRK05858 1205674005335 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205674005336 PYR/PP interface [polypeptide binding]; other site 1205674005337 dimer interface [polypeptide binding]; other site 1205674005338 TPP binding site [chemical binding]; other site 1205674005339 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205674005340 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1205674005341 TPP-binding site; other site 1205674005342 dimer interface [polypeptide binding]; other site 1205674005343 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1205674005344 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1205674005345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205674005346 nucleotide binding region [chemical binding]; other site 1205674005347 ATP-binding site [chemical binding]; other site 1205674005348 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205674005349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205674005350 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205674005351 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1205674005352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205674005353 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205674005354 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1205674005355 lipoyl attachment site [posttranslational modification]; other site 1205674005356 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674005357 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674005358 phosphopeptide binding site; other site 1205674005359 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1205674005360 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205674005361 DNA binding residues [nucleotide binding] 1205674005362 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1205674005363 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1205674005364 DNA binding residues [nucleotide binding] 1205674005365 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205674005366 putative dimer interface [polypeptide binding]; other site 1205674005367 glycine dehydrogenase; Provisional; Region: PRK05367 1205674005368 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1205674005369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674005370 tetramer interface [polypeptide binding]; other site 1205674005371 catalytic residue [active] 1205674005372 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1205674005373 tetramer interface [polypeptide binding]; other site 1205674005374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674005375 catalytic residue [active] 1205674005376 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 17443846; Product type pe : putative enzyme 1205674005377 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 17443846; Product type pe : putative enzyme 1205674005378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205674005379 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1205674005380 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1205674005381 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205674005382 metal ion-dependent adhesion site (MIDAS); other site 1205674005383 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1205674005384 active site 1205674005385 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205674005386 putative active site [active] 1205674005387 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205674005388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205674005389 FOG: CBS domain [General function prediction only]; Region: COG0517 1205674005390 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205674005391 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205674005392 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205674005393 Transporter associated domain; Region: CorC_HlyC; smart01091 1205674005394 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1205674005395 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205674005396 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205674005397 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205674005398 active site 1205674005399 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205674005400 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1205674005401 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1205674005402 Peptidase family M48; Region: Peptidase_M48; cl12018 1205674005403 Predicted transcriptional regulator [Transcription]; Region: COG3682 1205674005404 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205674005405 CoenzymeA binding site [chemical binding]; other site 1205674005406 subunit interaction site [polypeptide binding]; other site 1205674005407 PHB binding site; other site 1205674005408 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1205674005409 alpha-gamma subunit interface [polypeptide binding]; other site 1205674005410 beta-gamma subunit interface [polypeptide binding]; other site 1205674005411 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1205674005412 gamma-beta subunit interface [polypeptide binding]; other site 1205674005413 alpha-beta subunit interface [polypeptide binding]; other site 1205674005414 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1205674005415 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1205674005416 subunit interactions [polypeptide binding]; other site 1205674005417 active site 1205674005418 flap region; other site 1205674005419 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1205674005420 UreF; Region: UreF; pfam01730 1205674005421 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205674005422 UreD urease accessory protein; Region: UreD; cl00530 1205674005423 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205674005424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674005425 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205674005426 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674005427 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674005428 short chain dehydrogenase; Provisional; Region: PRK05884 1205674005429 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1205674005430 NAD(P) binding site [chemical binding]; other site 1205674005431 active site 1205674005432 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1205674005433 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205674005434 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205674005435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674005436 dimer interface [polypeptide binding]; other site 1205674005437 conserved gate region; other site 1205674005438 putative PBP binding loops; other site 1205674005439 ABC-ATPase subunit interface; other site 1205674005440 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1205674005441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674005442 Walker A/P-loop; other site 1205674005443 ATP binding site [chemical binding]; other site 1205674005444 Q-loop/lid; other site 1205674005445 ABC transporter signature motif; other site 1205674005446 Walker B; other site 1205674005447 D-loop; other site 1205674005448 H-loop/switch region; other site 1205674005449 TOBE domain; Region: TOBE; pfam03459 1205674005450 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1205674005451 Predicted membrane protein [Function unknown]; Region: COG2261 1205674005452 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1205674005453 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1205674005454 putative NAD(P) binding site [chemical binding]; other site 1205674005455 putative substrate binding site [chemical binding]; other site 1205674005456 catalytic Zn binding site [ion binding]; other site 1205674005457 structural Zn binding site [ion binding]; other site 1205674005458 CAAX protease self-immunity; Region: Abi; pfam02517 1205674005459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1205674005460 MOSC domain; Region: MOSC; pfam03473 1205674005461 short chain dehydrogenase; Provisional; Region: PRK07825 1205674005462 classical (c) SDRs; Region: SDR_c; cd05233 1205674005463 NAD(P) binding site [chemical binding]; other site 1205674005464 active site 1205674005465 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205674005466 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205674005467 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205674005468 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205674005469 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1205674005470 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1205674005471 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205674005472 active site 1205674005473 hypothetical protein; Provisional; Region: PRK12320 1205674005474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674005475 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1205674005476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674005477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674005478 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205674005479 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1205674005480 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1205674005481 active site 1205674005482 substrate binding site [chemical binding]; other site 1205674005483 FMN binding site [chemical binding]; other site 1205674005484 putative catalytic residues [active] 1205674005485 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1205674005486 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205674005487 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1205674005488 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1205674005489 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1205674005490 heme binding site [chemical binding]; other site 1205674005491 ferroxidase pore; other site 1205674005492 ferroxidase diiron center [ion binding]; other site 1205674005493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674005494 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674005495 putative substrate translocation pore; other site 1205674005496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674005497 putative substrate translocation pore; other site 1205674005498 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205674005499 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205674005500 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205674005501 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205674005502 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674005503 Cytochrome P450; Region: p450; cl12078 1205674005504 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1205674005505 short chain dehydrogenase; Provisional; Region: PRK08267 1205674005506 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1205674005507 putative NAD(P) binding site [chemical binding]; other site 1205674005508 active site 1205674005509 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205674005510 hydrophobic ligand binding site; other site 1205674005511 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205674005512 chorismate mutase; Provisional; Region: PRK09269 1205674005513 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1205674005514 Putative esterase; Region: Esterase; pfam00756 1205674005515 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674005516 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674005517 YceI-like domain; Region: YceI; cl01001 1205674005518 Nitronate monooxygenase; Region: NMO; pfam03060 1205674005519 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205674005520 FMN binding site [chemical binding]; other site 1205674005521 substrate binding site [chemical binding]; other site 1205674005522 putative catalytic residue [active] 1205674005523 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674005524 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674005525 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1205674005526 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1205674005527 putative active site [active] 1205674005528 putative NTP binding site [chemical binding]; other site 1205674005529 putative nucleic acid binding site [nucleotide binding]; other site 1205674005530 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1205674005531 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1205674005532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205674005533 DNA-binding interface [nucleotide binding]; DNA binding site 1205674005534 Integrase core domain; Region: rve_3; cl15866 1205674005535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674005536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674005537 putative substrate translocation pore; other site 1205674005538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674005539 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674005540 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674005541 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205674005542 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1205674005543 active site 1205674005544 nucleophile elbow; other site 1205674005545 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1205674005546 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1205674005547 PE family; Region: PE; pfam00934 1205674005548 PE family; Region: PE; pfam00934 1205674005549 PE family; Region: PE; pfam00934 1205674005550 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005551 PPE family; Region: PPE; pfam00823 1205674005552 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005553 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674005554 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674005555 Secretory lipase; Region: LIP; pfam03583 1205674005556 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1205674005557 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205674005558 catalytic Zn binding site [ion binding]; other site 1205674005559 NAD(P) binding site [chemical binding]; other site 1205674005560 structural Zn binding site [ion binding]; other site 1205674005561 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674005562 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674005563 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1205674005564 putative active site [active] 1205674005565 dimerization interface [polypeptide binding]; other site 1205674005566 putative tRNAtyr binding site [nucleotide binding]; other site 1205674005567 Domain of unknown function DUF77; Region: DUF77; pfam01910 1205674005568 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11271494, 12657046, 17443846 1205674005569 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674005570 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674005571 cyclase homology domain; Region: CHD; cd07302 1205674005572 nucleotidyl binding site; other site 1205674005573 metal binding site [ion binding]; metal-binding site 1205674005574 dimer interface [polypeptide binding]; other site 1205674005575 competence damage-inducible protein A; Provisional; Region: PRK00549 1205674005576 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1205674005577 putative MPT binding site; other site 1205674005578 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1205674005579 putative sialic acid transporter; Region: 2A0112; TIGR00891 1205674005580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674005581 putative substrate translocation pore; other site 1205674005582 Predicted membrane protein [Function unknown]; Region: COG1950 1205674005583 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205674005584 anti sigma factor interaction site; other site 1205674005585 regulatory phosphorylation site [posttranslational modification]; other site 1205674005586 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1205674005587 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1205674005588 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1205674005589 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1205674005590 dimer interface [polypeptide binding]; other site 1205674005591 active site 1205674005592 heme binding site [chemical binding]; other site 1205674005593 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1205674005594 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205674005595 metal binding site 2 [ion binding]; metal-binding site 1205674005596 putative DNA binding helix; other site 1205674005597 metal binding site 1 [ion binding]; metal-binding site 1205674005598 dimer interface [polypeptide binding]; other site 1205674005599 structural Zn2+ binding site [ion binding]; other site 1205674005600 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674005601 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674005602 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205674005603 substrate binding site [chemical binding]; other site 1205674005604 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205674005605 substrate binding site [chemical binding]; other site 1205674005606 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205674005607 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1205674005608 putative NAD(P) binding site [chemical binding]; other site 1205674005609 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205674005610 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205674005611 tetramer interface [polypeptide binding]; other site 1205674005612 active site 1205674005613 Mg2+/Mn2+ binding site [ion binding]; other site 1205674005614 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1205674005615 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005616 PPE family; Region: PPE; pfam00823 1205674005617 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674005618 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674005619 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674005620 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674005621 PPE family; Region: PPE; pfam00823 1205674005622 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674005623 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674005624 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205674005625 putative hydrophobic ligand binding site [chemical binding]; other site 1205674005626 protein interface [polypeptide binding]; other site 1205674005627 gate; other site 1205674005628 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674005629 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205674005630 putative acyl-acceptor binding pocket; other site 1205674005631 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205674005632 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674005633 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674005634 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674005635 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674005636 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1205674005637 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674005638 acyl-activating enzyme (AAE) consensus motif; other site 1205674005639 active site 1205674005640 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1205674005641 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1205674005642 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674005643 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15024109; Product type pe : putative enzyme 1205674005644 TIGR03085 family protein; Region: TIGR03085 1205674005645 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1205674005646 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1205674005647 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1205674005648 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1205674005649 conserved cys residue [active] 1205674005650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205674005651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205674005652 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1205674005653 dimer interface [polypeptide binding]; other site 1205674005654 catalytic triad [active] 1205674005655 peroxidatic and resolving cysteines [active] 1205674005656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674005657 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205674005658 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205674005659 active site 1205674005660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674005661 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205674005662 FAD binding site [chemical binding]; other site 1205674005663 substrate binding site [chemical binding]; other site 1205674005664 catalytic base [active] 1205674005665 enoyl-CoA hydratase; Provisional; Region: PRK08290 1205674005666 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674005667 substrate binding site [chemical binding]; other site 1205674005668 oxyanion hole (OAH) forming residues; other site 1205674005669 trimer interface [polypeptide binding]; other site 1205674005670 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674005671 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205674005672 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1205674005673 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674005674 catalytic loop [active] 1205674005675 iron binding site [ion binding]; other site 1205674005676 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1205674005677 FAD binding pocket [chemical binding]; other site 1205674005678 FAD binding motif [chemical binding]; other site 1205674005679 phosphate binding motif [ion binding]; other site 1205674005680 beta-alpha-beta structure motif; other site 1205674005681 NAD binding pocket [chemical binding]; other site 1205674005682 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674005683 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205674005684 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205674005685 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1205674005686 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1205674005687 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1205674005688 dimerization interface [polypeptide binding]; other site 1205674005689 active site 1205674005690 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1205674005691 putative NAD(P) binding site [chemical binding]; other site 1205674005692 active site 1205674005693 homodimer interface [polypeptide binding]; other site 1205674005694 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205674005695 SEC-C motif; Region: SEC-C; pfam02810 1205674005696 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674005697 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674005698 active site 1205674005699 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1205674005700 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1205674005701 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205674005702 putative active site [active] 1205674005703 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205674005704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674005705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674005706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674005707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674005708 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674005709 Permease; Region: Permease; pfam02405 1205674005710 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674005711 Permease; Region: Permease; pfam02405 1205674005712 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674005713 mce related protein; Region: MCE; pfam02470 1205674005714 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674005715 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674005716 mce related protein; Region: MCE; pfam02470 1205674005717 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674005718 mce related protein; Region: MCE; pfam02470 1205674005719 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674005720 mce related protein; Region: MCE; pfam02470 1205674005721 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674005722 mce related protein; Region: MCE; pfam02470 1205674005723 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674005724 mce related protein; Region: MCE; pfam02470 1205674005725 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674005726 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1205674005727 YacP-like NYN domain; Region: NYN_YacP; cl01491 1205674005728 PE family; Region: PE; pfam00934 1205674005729 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205674005730 Peptidase family M48; Region: Peptidase_M48; pfam01435 1205674005731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674005732 S-adenosylmethionine binding site [chemical binding]; other site 1205674005733 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205674005734 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1205674005735 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1205674005736 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1205674005737 dimer interface [polypeptide binding]; other site 1205674005738 putative radical transfer pathway; other site 1205674005739 diiron center [ion binding]; other site 1205674005740 tyrosyl radical; other site 1205674005741 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205674005742 putative active site [active] 1205674005743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205674005744 PE family; Region: PE; pfam00934 1205674005745 Cutinase; Region: Cutinase; pfam01083 1205674005746 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1205674005747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205674005748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205674005749 dimerization interface [polypeptide binding]; other site 1205674005750 Lysine efflux permease [General function prediction only]; Region: COG1279 1205674005751 Cellulose binding domain; Region: CBM_2; pfam00553 1205674005752 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205674005753 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674005754 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1205674005755 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674005756 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205674005757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674005758 dimerization interface [polypeptide binding]; other site 1205674005759 putative DNA binding site [nucleotide binding]; other site 1205674005760 putative Zn2+ binding site [ion binding]; other site 1205674005761 Hemerythrin-like domain; Region: Hr-like; cd12108 1205674005762 Fe binding site [ion binding]; other site 1205674005763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674005764 Ligand Binding Site [chemical binding]; other site 1205674005765 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674005766 Ligand Binding Site [chemical binding]; other site 1205674005767 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205674005768 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1205674005769 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674005770 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1205674005771 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205674005772 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205674005773 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205674005774 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1205674005775 tetramer interface [polypeptide binding]; other site 1205674005776 active site 1205674005777 Mg2+/Mn2+ binding site [ion binding]; other site 1205674005778 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205674005779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205674005780 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1205674005781 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1205674005782 homotetramer interface [polypeptide binding]; other site 1205674005783 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205674005784 NAD binding site [chemical binding]; other site 1205674005785 homodimer interface [polypeptide binding]; other site 1205674005786 active site 1205674005787 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205674005788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674005789 S-adenosylmethionine binding site [chemical binding]; other site 1205674005790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1205674005791 Predicted kinase [General function prediction only]; Region: COG0645 1205674005792 AAA domain; Region: AAA_17; pfam13207 1205674005793 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674005794 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674005795 Ligand Binding Site [chemical binding]; other site 1205674005796 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1205674005797 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1205674005798 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1205674005799 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1205674005800 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1205674005801 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1205674005802 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1205674005803 Ferredoxin [Energy production and conversion]; Region: COG1146 1205674005804 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205674005805 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205674005806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674005807 Walker A motif; other site 1205674005808 ATP binding site [chemical binding]; other site 1205674005809 Walker B motif; other site 1205674005810 arginine finger; other site 1205674005811 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205674005812 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205674005813 putative active site [active] 1205674005814 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205674005815 MarR family; Region: MarR_2; pfam12802 1205674005816 Phage envelope protein [General function prediction only]; Region: COG5562 1205674005817 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674005818 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674005819 active site 1205674005820 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205674005821 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674005822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674005823 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674005824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674005825 sequence-specific DNA binding site [nucleotide binding]; other site 1205674005826 salt bridge; other site 1205674005827 RES domain; Region: RES; cl02411 1205674005828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674005829 non-specific DNA binding site [nucleotide binding]; other site 1205674005830 salt bridge; other site 1205674005831 sequence-specific DNA binding site [nucleotide binding]; other site 1205674005832 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1205674005833 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1205674005834 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205674005835 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674005836 P-loop; other site 1205674005837 Magnesium ion binding site [ion binding]; other site 1205674005838 Predicted helicase [General function prediction only]; Region: COG4889 1205674005839 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1205674005840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674005841 ATP binding site [chemical binding]; other site 1205674005842 putative Mg++ binding site [ion binding]; other site 1205674005843 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1205674005844 ATP-binding site [chemical binding]; other site 1205674005845 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205674005846 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1205674005847 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1205674005848 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674005849 Ligand Binding Site [chemical binding]; other site 1205674005850 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674005851 Ligand Binding Site [chemical binding]; other site 1205674005852 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205674005853 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205674005854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205674005855 Histidine kinase; Region: HisKA_3; pfam07730 1205674005856 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674005857 Ligand Binding Site [chemical binding]; other site 1205674005858 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1205674005859 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1205674005860 putative substrate binding site [chemical binding]; other site 1205674005861 putative ATP binding site [chemical binding]; other site 1205674005862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674005863 active site 1205674005864 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1205674005865 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1205674005866 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1205674005867 putative dimer interface [polypeptide binding]; other site 1205674005868 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205674005869 dimer interface [polypeptide binding]; other site 1205674005870 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1205674005871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674005872 putative DNA binding site [nucleotide binding]; other site 1205674005873 dimerization interface [polypeptide binding]; other site 1205674005874 putative Zn2+ binding site [ion binding]; other site 1205674005875 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1205674005876 putative hydrophobic ligand binding site [chemical binding]; other site 1205674005877 CLM binding site; other site 1205674005878 L1 loop; other site 1205674005879 DNA binding site [nucleotide binding] 1205674005880 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205674005881 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205674005882 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1205674005883 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205674005884 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1205674005885 nucleophile elbow; other site 1205674005886 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205674005887 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205674005888 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205674005889 Walker A/P-loop; other site 1205674005890 ATP binding site [chemical binding]; other site 1205674005891 Q-loop/lid; other site 1205674005892 ABC transporter signature motif; other site 1205674005893 Walker B; other site 1205674005894 D-loop; other site 1205674005895 H-loop/switch region; other site 1205674005896 TOBE domain; Region: TOBE_2; pfam08402 1205674005897 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205674005898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674005899 dimer interface [polypeptide binding]; other site 1205674005900 conserved gate region; other site 1205674005901 putative PBP binding loops; other site 1205674005902 ABC-ATPase subunit interface; other site 1205674005903 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1205674005904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674005905 dimer interface [polypeptide binding]; other site 1205674005906 conserved gate region; other site 1205674005907 putative PBP binding loops; other site 1205674005908 ABC-ATPase subunit interface; other site 1205674005909 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205674005910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205674005911 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1205674005912 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1205674005913 Isochorismatase family; Region: Isochorismatase; pfam00857 1205674005914 catalytic triad [active] 1205674005915 metal binding site [ion binding]; metal-binding site 1205674005916 conserved cis-peptide bond; other site 1205674005917 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1205674005918 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1205674005919 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205674005920 substrate binding pocket [chemical binding]; other site 1205674005921 catalytic triad [active] 1205674005922 hypothetical protein; Provisional; Region: PRK05865 1205674005923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674005924 NAD(P) binding site [chemical binding]; other site 1205674005925 active site 1205674005926 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1205674005927 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674005928 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674005929 active site 1205674005930 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674005931 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674005932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674005933 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674005934 Enoylreductase; Region: PKS_ER; smart00829 1205674005935 NAD(P) binding site [chemical binding]; other site 1205674005936 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205674005937 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674005938 putative NADP binding site [chemical binding]; other site 1205674005939 active site 1205674005940 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674005941 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674005942 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674005943 active site 1205674005944 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674005945 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674005946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674005947 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674005948 Enoylreductase; Region: PKS_ER; smart00829 1205674005949 NAD(P) binding site [chemical binding]; other site 1205674005950 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205674005951 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674005952 putative NADP binding site [chemical binding]; other site 1205674005953 active site 1205674005954 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674005955 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1205674005956 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1205674005957 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1205674005958 putative active site [active] 1205674005959 catalytic triad [active] 1205674005960 putative dimer interface [polypeptide binding]; other site 1205674005961 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1205674005962 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1205674005963 Ligand binding site; other site 1205674005964 Putative Catalytic site; other site 1205674005965 DXD motif; other site 1205674005966 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1205674005967 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205674005968 active site 1205674005969 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1205674005970 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1205674005971 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1205674005972 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1205674005973 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1205674005974 putative active site [active] 1205674005975 30S ribosomal protein S18; Provisional; Region: PRK13401 1205674005976 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1205674005977 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1205674005978 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205674005979 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1205674005980 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205674005981 intersubunit interface [polypeptide binding]; other site 1205674005982 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1205674005983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674005984 Walker A/P-loop; other site 1205674005985 ATP binding site [chemical binding]; other site 1205674005986 Q-loop/lid; other site 1205674005987 ABC transporter signature motif; other site 1205674005988 Walker B; other site 1205674005989 D-loop; other site 1205674005990 H-loop/switch region; other site 1205674005991 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1205674005992 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1205674005993 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1205674005994 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205674005995 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205674005996 PemK-like protein; Region: PemK; pfam02452 1205674005997 precorrin-3B synthase; Region: CobG; TIGR02435 1205674005998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205674005999 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1205674006000 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1205674006001 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1205674006002 active site 1205674006003 SAM binding site [chemical binding]; other site 1205674006004 homodimer interface [polypeptide binding]; other site 1205674006005 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1205674006006 active site 1205674006007 SAM binding site [chemical binding]; other site 1205674006008 homodimer interface [polypeptide binding]; other site 1205674006009 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205674006010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674006011 S-adenosylmethionine binding site [chemical binding]; other site 1205674006012 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1205674006013 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205674006014 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1205674006015 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674006016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674006017 DNA binding residues [nucleotide binding] 1205674006018 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1205674006019 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1205674006020 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1205674006021 active site 1205674006022 SAM binding site [chemical binding]; other site 1205674006023 homodimer interface [polypeptide binding]; other site 1205674006024 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1205674006025 active site 1205674006026 putative homodimer interface [polypeptide binding]; other site 1205674006027 SAM binding site [chemical binding]; other site 1205674006028 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1205674006029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674006030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674006031 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205674006032 NAD(P) binding site [chemical binding]; other site 1205674006033 active site 1205674006034 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205674006035 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1205674006036 putative active site [active] 1205674006037 catalytic site [active] 1205674006038 putative metal binding site [ion binding]; other site 1205674006039 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1205674006040 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1205674006041 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205674006042 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759, 17443846 1205674006043 hypothetical protein; Provisional; Region: PRK12705 1205674006044 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674006045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674006046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674006047 active site 1205674006048 ATP binding site [chemical binding]; other site 1205674006049 substrate binding site [chemical binding]; other site 1205674006050 activation loop (A-loop); other site 1205674006051 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674006052 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1205674006053 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1205674006054 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1205674006055 active site 1205674006056 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1205674006057 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1205674006058 active site 1205674006059 metal binding site 1 [ion binding]; metal-binding site 1205674006060 putative 5' ssDNA interaction site; other site 1205674006061 metal binding site 3; metal-binding site 1205674006062 metal binding site 2 [ion binding]; metal-binding site 1205674006063 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1205674006064 putative DNA binding site [nucleotide binding]; other site 1205674006065 putative metal binding site [ion binding]; other site 1205674006066 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205674006067 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1205674006068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674006069 ATP binding site [chemical binding]; other site 1205674006070 putative Mg++ binding site [ion binding]; other site 1205674006071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674006072 nucleotide binding region [chemical binding]; other site 1205674006073 ATP-binding site [chemical binding]; other site 1205674006074 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1205674006075 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1205674006076 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1205674006077 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1205674006078 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205674006079 WYL domain; Region: WYL; pfam13280 1205674006080 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205674006081 WYL domain; Region: WYL; pfam13280 1205674006082 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1205674006083 Evidence 4 : Homologs of previously reported genes of unknown function 1205674006084 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15024109, 15525680; Product type pe : putative enzyme 1205674006085 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15024109, 15525680; Product type pe : putative enzyme 1205674006086 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15024109, 15525680; Product type pe : putative enzyme 1205674006087 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15024109, 15525680; Product type pe : putative enzyme 1205674006088 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15024109, 15525680; Product type pe : putative enzyme 1205674006089 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1205674006090 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205674006091 putative active site [active] 1205674006092 PE family; Region: PE; pfam00934 1205674006093 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674006094 PPE family; Region: PPE; pfam00823 1205674006095 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1205674006096 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1205674006097 active site 1205674006098 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1205674006099 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1205674006100 active site 1205674006101 Pup-like protein; Region: Pup; pfam05639 1205674006102 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1205674006103 proteasome ATPase; Region: pup_AAA; TIGR03689 1205674006104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674006105 Walker A motif; other site 1205674006106 ATP binding site [chemical binding]; other site 1205674006107 Walker B motif; other site 1205674006108 arginine finger; other site 1205674006109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1205674006110 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1205674006111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674006112 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205674006113 Predicted membrane protein [Function unknown]; Region: COG3918 1205674006114 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1205674006115 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1205674006116 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1205674006117 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1205674006118 homodimer interface [polypeptide binding]; other site 1205674006119 putative metal binding site [ion binding]; other site 1205674006120 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674006121 PPE family; Region: PPE; pfam00823 1205674006122 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1205674006123 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1205674006124 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1205674006125 substrate binding pocket [chemical binding]; other site 1205674006126 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1205674006127 B12 binding site [chemical binding]; other site 1205674006128 cobalt ligand [ion binding]; other site 1205674006129 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1205674006130 PAC2 family; Region: PAC2; pfam09754 1205674006131 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205674006132 short chain dehydrogenase; Provisional; Region: PRK05872 1205674006133 classical (c) SDRs; Region: SDR_c; cd05233 1205674006134 NAD(P) binding site [chemical binding]; other site 1205674006135 active site 1205674006136 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205674006137 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1205674006138 active site 1205674006139 HIGH motif; other site 1205674006140 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674006141 active site 1205674006142 KMSKS motif; other site 1205674006143 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1205674006144 tRNA binding surface [nucleotide binding]; other site 1205674006145 anticodon binding site; other site 1205674006146 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1205674006147 active site 1205674006148 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674006149 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674006150 putative active site [active] 1205674006151 conserved hypothetical protein; Region: TIGR03843 1205674006152 conserved hypothetical protein; Region: TIGR03847 1205674006153 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674006154 catalytic core [active] 1205674006155 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1205674006156 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1205674006157 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1205674006158 quinone interaction residues [chemical binding]; other site 1205674006159 active site 1205674006160 catalytic residues [active] 1205674006161 FMN binding site [chemical binding]; other site 1205674006162 substrate binding site [chemical binding]; other site 1205674006163 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205674006164 substrate binding site [chemical binding]; other site 1205674006165 hypothetical protein; Provisional; Region: PRK07906 1205674006166 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1205674006167 putative metal binding site [ion binding]; other site 1205674006168 Putative addiction module component; Region: Unstab_antitox; cl09921 1205674006169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674006170 active site 1205674006171 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205674006172 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1205674006173 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205674006174 Predicted integral membrane protein [Function unknown]; Region: COG0762 1205674006175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1205674006176 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1205674006177 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205674006178 catalytic residue [active] 1205674006179 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1205674006180 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1205674006181 cell division protein FtsZ; Validated; Region: PRK09330 1205674006182 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1205674006183 nucleotide binding site [chemical binding]; other site 1205674006184 SulA interaction site; other site 1205674006185 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1205674006186 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1205674006187 Cell division protein FtsQ; Region: FtsQ; pfam03799 1205674006188 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1205674006189 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205674006190 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205674006191 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205674006192 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1205674006193 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1205674006194 active site 1205674006195 homodimer interface [polypeptide binding]; other site 1205674006196 cell division protein FtsW; Region: ftsW; TIGR02614 1205674006197 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1205674006198 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205674006199 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205674006200 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1205674006201 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1205674006202 Mg++ binding site [ion binding]; other site 1205674006203 putative catalytic motif [active] 1205674006204 putative substrate binding site [chemical binding]; other site 1205674006205 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205674006206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205674006207 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205674006208 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1205674006209 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205674006210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205674006211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205674006212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674006213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674006214 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205674006215 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674006216 PE family; Region: PE; pfam00934 1205674006217 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205674006218 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1205674006219 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205674006220 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1205674006221 MraW methylase family; Region: Methyltransf_5; pfam01795 1205674006222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1205674006223 MraZ protein; Region: MraZ; pfam02381 1205674006224 MraZ protein; Region: MraZ; pfam02381 1205674006225 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1205674006226 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1205674006227 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205674006228 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205674006229 substrate binding pocket [chemical binding]; other site 1205674006230 chain length determination region; other site 1205674006231 substrate-Mg2+ binding site; other site 1205674006232 catalytic residues [active] 1205674006233 aspartate-rich region 1; other site 1205674006234 active site lid residues [active] 1205674006235 aspartate-rich region 2; other site 1205674006236 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1205674006237 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674006238 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674006239 active site 1205674006240 ATP binding site [chemical binding]; other site 1205674006241 substrate binding site [chemical binding]; other site 1205674006242 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205674006243 substrate binding site [chemical binding]; other site 1205674006244 activation loop (A-loop); other site 1205674006245 activation loop (A-loop); other site 1205674006246 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1205674006247 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1205674006248 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674006249 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205674006250 putative acyl-acceptor binding pocket; other site 1205674006251 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205674006252 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205674006253 DTAP/Switch II; other site 1205674006254 Switch I; other site 1205674006255 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205674006256 putative hydrophobic ligand binding site [chemical binding]; other site 1205674006257 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205674006258 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205674006259 acyl-activating enzyme (AAE) consensus motif; other site 1205674006260 putative AMP binding site [chemical binding]; other site 1205674006261 putative active site [active] 1205674006262 putative CoA binding site [chemical binding]; other site 1205674006263 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205674006264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205674006265 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1205674006266 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205674006267 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205674006268 hypothetical protein; Validated; Region: PRK07883 1205674006269 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205674006270 active site 1205674006271 catalytic site [active] 1205674006272 substrate binding site [chemical binding]; other site 1205674006273 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205674006274 GIY-YIG motif/motif A; other site 1205674006275 active site 1205674006276 catalytic site [active] 1205674006277 putative DNA binding site [nucleotide binding]; other site 1205674006278 metal binding site [ion binding]; metal-binding site 1205674006279 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1205674006280 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205674006281 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205674006282 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1205674006283 Subunit I/III interface [polypeptide binding]; other site 1205674006284 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1205674006285 Cytochrome c; Region: Cytochrom_C; pfam00034 1205674006286 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1205674006287 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1205674006288 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1205674006289 iron-sulfur cluster [ion binding]; other site 1205674006290 [2Fe-2S] cluster binding site [ion binding]; other site 1205674006291 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1205674006292 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1205674006293 heme bH binding site [chemical binding]; other site 1205674006294 intrachain domain interface; other site 1205674006295 heme bL binding site [chemical binding]; other site 1205674006296 interchain domain interface [polypeptide binding]; other site 1205674006297 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1205674006298 Qo binding site; other site 1205674006299 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1205674006300 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205674006301 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1205674006302 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1205674006303 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1205674006304 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1205674006305 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1205674006306 dimer interface [polypeptide binding]; other site 1205674006307 active site 1205674006308 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1205674006309 Ligand Binding Site [chemical binding]; other site 1205674006310 Molecular Tunnel; other site 1205674006311 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1205674006312 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205674006313 substrate binding site [chemical binding]; other site 1205674006314 ATP binding site [chemical binding]; other site 1205674006315 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1205674006316 Glycerate kinase family; Region: Gly_kinase; pfam02595 1205674006317 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1205674006318 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1205674006319 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1205674006320 putative dimer interface [polypeptide binding]; other site 1205674006321 active site pocket [active] 1205674006322 putative cataytic base [active] 1205674006323 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1205674006324 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1205674006325 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1205674006326 homodimer interface [polypeptide binding]; other site 1205674006327 substrate-cofactor binding pocket; other site 1205674006328 catalytic residue [active] 1205674006329 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1205674006330 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1205674006331 cyclase homology domain; Region: CHD; cd07302 1205674006332 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674006333 nucleotidyl binding site; other site 1205674006334 metal binding site [ion binding]; metal-binding site 1205674006335 dimer interface [polypeptide binding]; other site 1205674006336 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1205674006337 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1205674006338 interface (dimer of trimers) [polypeptide binding]; other site 1205674006339 Substrate-binding/catalytic site; other site 1205674006340 Zn-binding sites [ion binding]; other site 1205674006341 short chain dehydrogenase; Validated; Region: PRK05855 1205674006342 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205674006343 classical (c) SDRs; Region: SDR_c; cd05233 1205674006344 NAD(P) binding site [chemical binding]; other site 1205674006345 active site 1205674006346 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1205674006347 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205674006348 E3 interaction surface; other site 1205674006349 lipoyl attachment site [posttranslational modification]; other site 1205674006350 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205674006351 E3 interaction surface; other site 1205674006352 lipoyl attachment site [posttranslational modification]; other site 1205674006353 e3 binding domain; Region: E3_binding; pfam02817 1205674006354 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205674006355 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1205674006356 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1205674006357 putative NAD(P) binding site [chemical binding]; other site 1205674006358 putative active site [active] 1205674006359 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674006360 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674006361 lipoate-protein ligase B; Provisional; Region: PRK14345 1205674006362 lipoyl synthase; Provisional; Region: PRK05481 1205674006363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674006364 FeS/SAM binding site; other site 1205674006365 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1205674006366 RDD family; Region: RDD; cl00746 1205674006367 glutamine synthetase, type I; Region: GlnA; TIGR00653 1205674006368 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205674006369 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205674006370 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1205674006371 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205674006372 metal binding triad; other site 1205674006373 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205674006374 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205674006375 metal binding triad; other site 1205674006376 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205674006377 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205674006378 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205674006379 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205674006380 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205674006381 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205674006382 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205674006383 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205674006384 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1205674006385 oligomerization interface [polypeptide binding]; other site 1205674006386 active site 1205674006387 metal binding site [ion binding]; metal-binding site 1205674006388 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1205674006389 putative active site; other site 1205674006390 putative metal binding residues [ion binding]; other site 1205674006391 signature motif; other site 1205674006392 putative triphosphate binding site [ion binding]; other site 1205674006393 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1205674006394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1205674006395 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1205674006396 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1205674006397 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205674006398 active site 1205674006399 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674006400 catalytic core [active] 1205674006401 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1205674006402 Putative zinc ribbon domain; Region: DUF164; pfam02591 1205674006403 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1205674006404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1205674006405 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1205674006406 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1205674006407 hypothetical protein; Provisional; Region: PRK07908 1205674006408 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674006409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674006410 homodimer interface [polypeptide binding]; other site 1205674006411 catalytic residue [active] 1205674006412 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1205674006413 putative active site [active] 1205674006414 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1205674006415 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1205674006416 Acid Phosphatase; Region: Acid_PPase; cl17256 1205674006417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674006418 motif II; other site 1205674006419 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205674006420 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1205674006421 active site 1205674006422 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1205674006423 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1205674006424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205674006425 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205674006426 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1205674006427 dimer interface [polypeptide binding]; other site 1205674006428 catalytic triad [active] 1205674006429 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1205674006430 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1205674006431 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1205674006432 dimer interface [polypeptide binding]; other site 1205674006433 TPP-binding site [chemical binding]; other site 1205674006434 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205674006435 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205674006436 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205674006437 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205674006438 acyl carrier protein; Provisional; Region: acpP; PRK00982 1205674006439 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1205674006440 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205674006441 dimer interface [polypeptide binding]; other site 1205674006442 active site 1205674006443 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1205674006444 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205674006445 dimer interface [polypeptide binding]; other site 1205674006446 active site 1205674006447 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205674006448 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205674006449 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205674006450 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205674006451 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1205674006452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674006453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674006454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674006455 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674006456 diacylglycerol kinase; Reviewed; Region: PRK11914 1205674006457 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205674006458 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1205674006459 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674006460 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674006461 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205674006462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674006463 S-adenosylmethionine binding site [chemical binding]; other site 1205674006464 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1205674006465 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205674006466 NAD binding site [chemical binding]; other site 1205674006467 catalytic Zn binding site [ion binding]; other site 1205674006468 substrate binding site [chemical binding]; other site 1205674006469 structural Zn binding site [ion binding]; other site 1205674006470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205674006471 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1205674006472 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1205674006473 putative active site [active] 1205674006474 catalytic triad [active] 1205674006475 putative dimer interface [polypeptide binding]; other site 1205674006476 short chain dehydrogenase; Provisional; Region: PRK05854 1205674006477 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205674006478 putative NAD(P) binding site [chemical binding]; other site 1205674006479 active site 1205674006480 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1205674006481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205674006482 nucleotide binding site [chemical binding]; other site 1205674006483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674006484 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674006485 Cytochrome P450; Region: p450; cl12078 1205674006486 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205674006487 Cytochrome P450; Region: p450; cl12078 1205674006488 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674006489 Septum formation; Region: Septum_form; pfam13845 1205674006490 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1205674006491 Domain of unknown function (DUF202); Region: DUF202; cl09954 1205674006492 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1205674006493 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674006494 Cytochrome P450; Region: p450; cl12078 1205674006495 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1205674006496 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205674006497 putative active site [active] 1205674006498 catalytic site [active] 1205674006499 putative metal binding site [ion binding]; other site 1205674006500 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205674006501 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674006502 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205674006503 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205674006504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205674006505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205674006506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205674006507 dimerization interface [polypeptide binding]; other site 1205674006508 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205674006509 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674006510 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205674006511 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674006512 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674006513 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205674006514 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205674006515 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1205674006516 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1205674006517 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205674006518 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205674006519 active site residue [active] 1205674006520 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205674006521 active site residue [active] 1205674006522 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1205674006523 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1205674006524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674006525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674006526 homodimer interface [polypeptide binding]; other site 1205674006527 catalytic residue [active] 1205674006528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1205674006529 haloalkane dehalogenase; Provisional; Region: PRK00870 1205674006530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205674006531 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205674006532 active site 1205674006533 catalytic tetrad [active] 1205674006534 heat shock protein 90; Provisional; Region: PRK05218 1205674006535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674006536 ATP binding site [chemical binding]; other site 1205674006537 Mg2+ binding site [ion binding]; other site 1205674006538 G-X-G motif; other site 1205674006539 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205674006540 Cutinase; Region: Cutinase; pfam01083 1205674006541 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205674006542 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205674006543 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1205674006544 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205674006545 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205674006546 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205674006547 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1205674006548 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type e : enzyme 1205674006549 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205674006550 DNA binding residues [nucleotide binding] 1205674006551 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205674006552 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1205674006553 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1205674006554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674006555 putative PBP binding loops; other site 1205674006556 ABC-ATPase subunit interface; other site 1205674006557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205674006558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674006559 dimer interface [polypeptide binding]; other site 1205674006560 conserved gate region; other site 1205674006561 putative PBP binding loops; other site 1205674006562 ABC-ATPase subunit interface; other site 1205674006563 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205674006564 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205674006565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674006566 Ligand Binding Site [chemical binding]; other site 1205674006567 Universal stress protein family; Region: Usp; pfam00582 1205674006568 amino acid transporter; Region: 2A0306; TIGR00909 1205674006569 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1205674006570 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205674006571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674006572 catalytic residue [active] 1205674006573 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205674006574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674006575 Amidinotransferase; Region: Amidinotransf; pfam02274 1205674006576 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1205674006577 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205674006578 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1205674006579 putative DNA binding site [nucleotide binding]; other site 1205674006580 putative Zn2+ binding site [ion binding]; other site 1205674006581 AsnC family; Region: AsnC_trans_reg; pfam01037 1205674006582 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674006583 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674006584 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1205674006585 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205674006586 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1205674006587 Walker A/P-loop; other site 1205674006588 ATP binding site [chemical binding]; other site 1205674006589 Q-loop/lid; other site 1205674006590 ABC transporter signature motif; other site 1205674006591 Walker B; other site 1205674006592 D-loop; other site 1205674006593 H-loop/switch region; other site 1205674006594 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205674006595 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205674006596 Walker A/P-loop; other site 1205674006597 ATP binding site [chemical binding]; other site 1205674006598 Q-loop/lid; other site 1205674006599 ABC transporter signature motif; other site 1205674006600 Walker B; other site 1205674006601 D-loop; other site 1205674006602 H-loop/switch region; other site 1205674006603 MarR family; Region: MarR; pfam01047 1205674006604 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205674006605 PE family; Region: PE; pfam00934 1205674006606 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205674006607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674006608 putative substrate translocation pore; other site 1205674006609 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205674006610 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674006611 malate dehydrogenase; Provisional; Region: PRK13529 1205674006612 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1205674006613 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1205674006614 NAD(P) binding site [chemical binding]; other site 1205674006615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674006616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674006617 putative substrate translocation pore; other site 1205674006618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674006619 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205674006620 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205674006621 dimer interface [polypeptide binding]; other site 1205674006622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674006623 catalytic residue [active] 1205674006624 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1205674006625 serine O-acetyltransferase; Region: cysE; TIGR01172 1205674006626 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1205674006627 trimer interface [polypeptide binding]; other site 1205674006628 active site 1205674006629 substrate binding site [chemical binding]; other site 1205674006630 CoA binding site [chemical binding]; other site 1205674006631 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1205674006632 hypothetical protein; Provisional; Region: PRK14851 1205674006633 hypothetical protein; Validated; Region: PRK08223 1205674006634 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1205674006635 ATP binding site [chemical binding]; other site 1205674006636 substrate interface [chemical binding]; other site 1205674006637 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674006638 PE family; Region: PE; pfam00934 1205674006639 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674006640 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674006641 DNA primase; Validated; Region: dnaG; PRK05667 1205674006642 CHC2 zinc finger; Region: zf-CHC2; cl17510 1205674006643 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1205674006644 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1205674006645 active site 1205674006646 metal binding site [ion binding]; metal-binding site 1205674006647 interdomain interaction site; other site 1205674006648 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1205674006649 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1205674006650 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1205674006651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205674006652 Zn2+ binding site [ion binding]; other site 1205674006653 Mg2+ binding site [ion binding]; other site 1205674006654 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1205674006655 Repair protein; Region: Repair_PSII; pfam04536 1205674006656 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205674006657 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205674006658 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205674006659 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205674006660 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205674006661 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205674006662 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205674006663 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205674006664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205674006665 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205674006666 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674006667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674006668 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674006669 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674006670 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674006671 PPE family; Region: PPE; pfam00823 1205674006672 PPE family; Region: PPE; pfam00823 1205674006673 PPE family; Region: PPE; pfam00823 1205674006674 PPE family; Region: PPE; pfam00823 1205674006675 PPE family; Region: PPE; pfam00823 1205674006676 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1205674006677 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205674006678 motif 1; other site 1205674006679 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1205674006680 active site 1205674006681 motif 2; other site 1205674006682 motif 3; other site 1205674006683 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1205674006684 anticodon binding site; other site 1205674006685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674006686 dimerization interface [polypeptide binding]; other site 1205674006687 putative DNA binding site [nucleotide binding]; other site 1205674006688 putative Zn2+ binding site [ion binding]; other site 1205674006689 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205674006690 metal binding site 2 [ion binding]; metal-binding site 1205674006691 putative DNA binding helix; other site 1205674006692 metal binding site 1 [ion binding]; metal-binding site 1205674006693 dimer interface [polypeptide binding]; other site 1205674006694 structural Zn2+ binding site [ion binding]; other site 1205674006695 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1205674006696 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1205674006697 catalytic residue [active] 1205674006698 putative FPP diphosphate binding site; other site 1205674006699 putative FPP binding hydrophobic cleft; other site 1205674006700 dimer interface [polypeptide binding]; other site 1205674006701 putative IPP diphosphate binding site; other site 1205674006702 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1205674006703 Recombination protein O N terminal; Region: RecO_N; pfam11967 1205674006704 Recombination protein O C terminal; Region: RecO_C; pfam02565 1205674006705 amidase; Provisional; Region: PRK06061 1205674006706 Amidase; Region: Amidase; pfam01425 1205674006707 GTPase Era; Reviewed; Region: era; PRK00089 1205674006708 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1205674006709 G1 box; other site 1205674006710 GTP/Mg2+ binding site [chemical binding]; other site 1205674006711 Switch I region; other site 1205674006712 G2 box; other site 1205674006713 Switch II region; other site 1205674006714 G3 box; other site 1205674006715 G4 box; other site 1205674006716 G5 box; other site 1205674006717 KH domain; Region: KH_2; pfam07650 1205674006718 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205674006719 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205674006720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205674006721 Transporter associated domain; Region: CorC_HlyC; smart01091 1205674006722 metal-binding heat shock protein; Provisional; Region: PRK00016 1205674006723 K homology RNA-binding domain; Region: KH; smart00322 1205674006724 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1205674006725 PhoH-like protein; Region: PhoH; pfam02562 1205674006726 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205674006727 PE family; Region: PE; pfam00934 1205674006728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1205674006729 RNA methyltransferase, RsmE family; Region: TIGR00046 1205674006730 chaperone protein DnaJ; Provisional; Region: PRK14278 1205674006731 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205674006732 HSP70 interaction site [polypeptide binding]; other site 1205674006733 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205674006734 Zn binding sites [ion binding]; other site 1205674006735 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205674006736 dimer interface [polypeptide binding]; other site 1205674006737 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1205674006738 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205674006739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1205674006740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674006741 Condensation domain; Region: Condensation; pfam00668 1205674006742 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205674006743 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205674006744 acyl-activating enzyme (AAE) consensus motif; other site 1205674006745 AMP binding site [chemical binding]; other site 1205674006746 Condensation domain; Region: Condensation; pfam00668 1205674006747 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205674006748 Condensation domain; Region: Condensation; pfam00668 1205674006749 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205674006750 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205674006751 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205674006752 acyl-activating enzyme (AAE) consensus motif; other site 1205674006753 AMP binding site [chemical binding]; other site 1205674006754 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674006755 Condensation domain; Region: Condensation; pfam00668 1205674006756 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205674006757 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205674006758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674006759 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674006760 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205674006761 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674006762 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205674006763 NADP binding site [chemical binding]; other site 1205674006764 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674006765 active site 1205674006766 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674006767 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674006768 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205674006769 active site 1205674006770 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1205674006771 Condensation domain; Region: Condensation; pfam00668 1205674006772 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205674006773 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1205674006774 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1205674006775 acyl-activating enzyme (AAE) consensus motif; other site 1205674006776 AMP binding site [chemical binding]; other site 1205674006777 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674006778 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205674006779 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1205674006780 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1205674006781 acyl-activating enzyme (AAE) consensus motif; other site 1205674006782 active site 1205674006783 AMP binding site [chemical binding]; other site 1205674006784 substrate binding site [chemical binding]; other site 1205674006785 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205674006786 salicylate synthase MbtI; Reviewed; Region: PRK07912 1205674006787 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205674006788 Predicted permease [General function prediction only]; Region: COG3329 1205674006789 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1205674006790 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205674006791 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1205674006792 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205674006793 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205674006794 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1205674006795 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1205674006796 Active Sites [active] 1205674006797 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205674006798 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1205674006799 putative active site [active] 1205674006800 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1205674006801 putative active site [active] 1205674006802 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1205674006803 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1205674006804 Predicted membrane protein [Function unknown]; Region: COG1297 1205674006805 putative oligopeptide transporter, OPT family; Region: TIGR00733 1205674006806 PE family; Region: PE; pfam00934 1205674006807 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1205674006808 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1205674006809 Walker A/P-loop; other site 1205674006810 ATP binding site [chemical binding]; other site 1205674006811 Q-loop/lid; other site 1205674006812 ABC transporter signature motif; other site 1205674006813 Walker B; other site 1205674006814 D-loop; other site 1205674006815 H-loop/switch region; other site 1205674006816 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205674006817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674006818 dimer interface [polypeptide binding]; other site 1205674006819 conserved gate region; other site 1205674006820 putative PBP binding loops; other site 1205674006821 ABC-ATPase subunit interface; other site 1205674006822 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205674006823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674006824 dimer interface [polypeptide binding]; other site 1205674006825 conserved gate region; other site 1205674006826 putative PBP binding loops; other site 1205674006827 ABC-ATPase subunit interface; other site 1205674006828 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205674006829 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1205674006830 Evidence 4 : Homologs of previously reported genes of unknown function 1205674006831 Evidence 4 : Homologs of previously reported genes of unknown function 1205674006832 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1205674006833 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1205674006834 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674006835 GTP-binding protein LepA; Provisional; Region: PRK05433 1205674006836 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1205674006837 G1 box; other site 1205674006838 putative GEF interaction site [polypeptide binding]; other site 1205674006839 GTP/Mg2+ binding site [chemical binding]; other site 1205674006840 Switch I region; other site 1205674006841 G2 box; other site 1205674006842 G3 box; other site 1205674006843 Switch II region; other site 1205674006844 G4 box; other site 1205674006845 G5 box; other site 1205674006846 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1205674006847 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1205674006848 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1205674006849 PemK-like protein; Region: PemK; pfam02452 1205674006850 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1205674006851 FOG: CBS domain [General function prediction only]; Region: COG0517 1205674006852 ribonuclease Z; Reviewed; Region: PRK00055 1205674006853 Evidence 4 : Homologs of previously reported genes of unknown function 1205674006854 Evidence 4 : Homologs of previously reported genes of unknown function 1205674006855 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205674006856 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205674006857 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205674006858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1205674006859 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1205674006860 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1205674006861 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1205674006862 hypothetical protein; Reviewed; Region: PRK07914 1205674006863 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1205674006864 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1205674006865 Competence protein; Region: Competence; pfam03772 1205674006866 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1205674006867 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205674006868 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1205674006869 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674006870 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674006871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674006872 Coenzyme A binding pocket [chemical binding]; other site 1205674006873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1205674006874 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1205674006875 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1205674006876 active site 1205674006877 catalytic triad [active] 1205674006878 oxyanion hole [active] 1205674006879 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674006880 catalytic core [active] 1205674006881 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1205674006882 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1205674006883 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1205674006884 active site 1205674006885 (T/H)XGH motif; other site 1205674006886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674006887 S-adenosylmethionine binding site [chemical binding]; other site 1205674006888 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674006889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674006890 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674006891 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674006892 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1205674006893 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205674006894 metal ion-dependent adhesion site (MIDAS); other site 1205674006895 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1205674006896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674006897 Walker A motif; other site 1205674006898 ATP binding site [chemical binding]; other site 1205674006899 Walker B motif; other site 1205674006900 arginine finger; other site 1205674006901 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1205674006902 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1205674006903 putative catalytic cysteine [active] 1205674006904 Evidence 4 : Homologs of previously reported genes of unknown function 1205674006905 Evidence 4 : Homologs of previously reported genes of unknown function 1205674006906 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205674006907 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1205674006908 dimer interface [polypeptide binding]; other site 1205674006909 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1205674006910 catalytic triad [active] 1205674006911 peroxidatic and resolving cysteines [active] 1205674006912 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1205674006913 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1205674006914 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674006915 PPE family; Region: PPE; pfam00823 1205674006916 PE family; Region: PE; pfam00934 1205674006917 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1205674006918 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1205674006919 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674006920 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674006921 ligand binding site [chemical binding]; other site 1205674006922 flexible hinge region; other site 1205674006923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674006924 dimerization interface [polypeptide binding]; other site 1205674006925 Heme NO binding associated; Region: HNOBA; pfam07701 1205674006926 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1205674006927 cyclase homology domain; Region: CHD; cd07302 1205674006928 nucleotidyl binding site; other site 1205674006929 metal binding site [ion binding]; metal-binding site 1205674006930 dimer interface [polypeptide binding]; other site 1205674006931 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205674006932 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1205674006933 substrate binding site [chemical binding]; other site 1205674006934 ATP binding site [chemical binding]; other site 1205674006935 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1205674006936 NAD synthetase; Reviewed; Region: nadE; PRK02628 1205674006937 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1205674006938 multimer interface [polypeptide binding]; other site 1205674006939 active site 1205674006940 catalytic triad [active] 1205674006941 protein interface 1 [polypeptide binding]; other site 1205674006942 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1205674006943 homodimer interface [polypeptide binding]; other site 1205674006944 NAD binding pocket [chemical binding]; other site 1205674006945 ATP binding pocket [chemical binding]; other site 1205674006946 Mg binding site [ion binding]; other site 1205674006947 active-site loop [active] 1205674006948 gamma-glutamyl kinase; Provisional; Region: PRK05429 1205674006949 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1205674006950 nucleotide binding site [chemical binding]; other site 1205674006951 homotetrameric interface [polypeptide binding]; other site 1205674006952 putative phosphate binding site [ion binding]; other site 1205674006953 putative allosteric binding site; other site 1205674006954 PUA domain; Region: PUA; pfam01472 1205674006955 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1205674006956 GTP1/OBG; Region: GTP1_OBG; pfam01018 1205674006957 Obg GTPase; Region: Obg; cd01898 1205674006958 G1 box; other site 1205674006959 GTP/Mg2+ binding site [chemical binding]; other site 1205674006960 Switch I region; other site 1205674006961 G2 box; other site 1205674006962 G3 box; other site 1205674006963 Switch II region; other site 1205674006964 G4 box; other site 1205674006965 G5 box; other site 1205674006966 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1205674006967 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1205674006968 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1205674006969 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1205674006970 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1205674006971 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1205674006972 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1205674006973 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1205674006974 homodimer interface [polypeptide binding]; other site 1205674006975 oligonucleotide binding site [chemical binding]; other site 1205674006976 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1205674006977 active site 1205674006978 multimer interface [polypeptide binding]; other site 1205674006979 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1205674006980 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1205674006981 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205674006982 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1205674006983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674006984 active site 1205674006985 HIGH motif; other site 1205674006986 nucleotide binding site [chemical binding]; other site 1205674006987 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1205674006988 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1205674006989 active site 1205674006990 KMSKS motif; other site 1205674006991 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1205674006992 tRNA binding surface [nucleotide binding]; other site 1205674006993 anticodon binding site; other site 1205674006994 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1205674006995 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1205674006996 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1205674006997 NAD(P) binding pocket [chemical binding]; other site 1205674006998 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205674006999 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1205674007000 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1205674007001 GTP binding site; other site 1205674007002 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1205674007003 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1205674007004 TPP-binding site [chemical binding]; other site 1205674007005 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1205674007006 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1205674007007 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1205674007008 dimer interface [polypeptide binding]; other site 1205674007009 PYR/PP interface [polypeptide binding]; other site 1205674007010 TPP binding site [chemical binding]; other site 1205674007011 substrate binding site [chemical binding]; other site 1205674007012 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1205674007013 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1205674007014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674007015 Walker A motif; other site 1205674007016 ATP binding site [chemical binding]; other site 1205674007017 Walker B motif; other site 1205674007018 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1205674007019 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1205674007020 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1205674007021 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1205674007022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674007023 putative substrate translocation pore; other site 1205674007024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674007025 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1205674007026 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205674007027 oligomer interface [polypeptide binding]; other site 1205674007028 active site residues [active] 1205674007029 Clp protease; Region: CLP_protease; pfam00574 1205674007030 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205674007031 oligomer interface [polypeptide binding]; other site 1205674007032 active site residues [active] 1205674007033 trigger factor; Provisional; Region: tig; PRK01490 1205674007034 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1205674007035 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1205674007036 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674007037 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674007038 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205674007039 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1205674007040 putative DNA binding site [nucleotide binding]; other site 1205674007041 catalytic residue [active] 1205674007042 putative H2TH interface [polypeptide binding]; other site 1205674007043 putative catalytic residues [active] 1205674007044 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205674007045 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205674007046 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1205674007047 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205674007048 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205674007049 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1205674007050 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1205674007051 Zn binding site [ion binding]; other site 1205674007052 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1205674007053 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674007054 active site 1205674007055 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1205674007056 apolar tunnel; other site 1205674007057 heme binding site [chemical binding]; other site 1205674007058 dimerization interface [polypeptide binding]; other site 1205674007059 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1205674007060 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1205674007061 active site 1205674007062 catalytic site [active] 1205674007063 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205674007064 active site 1205674007065 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1205674007066 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1205674007067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674007068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674007069 ABC transporter; Region: ABC_tran_2; pfam12848 1205674007070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205674007071 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1205674007072 dimer interface [polypeptide binding]; other site 1205674007073 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1205674007074 ssDNA binding site [nucleotide binding]; other site 1205674007075 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1205674007076 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1205674007077 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1205674007078 putative acyl-acceptor binding pocket; other site 1205674007079 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205674007080 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1205674007081 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674007082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205674007083 putative acyl-acceptor binding pocket; other site 1205674007084 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674007085 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674007086 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205674007087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205674007088 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205674007089 enoyl-CoA hydratase; Provisional; Region: PRK05870 1205674007090 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674007091 substrate binding site [chemical binding]; other site 1205674007092 oxyanion hole (OAH) forming residues; other site 1205674007093 trimer interface [polypeptide binding]; other site 1205674007094 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674007095 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674007096 PE family; Region: PE; pfam00934 1205674007097 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674007098 cyclase homology domain; Region: CHD; cd07302 1205674007099 nucleotidyl binding site; other site 1205674007100 metal binding site [ion binding]; metal-binding site 1205674007101 dimer interface [polypeptide binding]; other site 1205674007102 Predicted ATPase [General function prediction only]; Region: COG3903 1205674007103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674007104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674007105 DNA binding residues [nucleotide binding] 1205674007106 dimerization interface [polypeptide binding]; other site 1205674007107 PE family; Region: PE; pfam00934 1205674007108 TIGR00725 family protein; Region: TIGR00725 1205674007109 thymidylate synthase; Provisional; Region: thyA; PRK00956 1205674007110 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674007111 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1205674007112 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205674007113 E3 interaction surface; other site 1205674007114 lipoyl attachment site [posttranslational modification]; other site 1205674007115 e3 binding domain; Region: E3_binding; pfam02817 1205674007116 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205674007117 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1205674007118 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1205674007119 alpha subunit interface [polypeptide binding]; other site 1205674007120 TPP binding site [chemical binding]; other site 1205674007121 heterodimer interface [polypeptide binding]; other site 1205674007122 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205674007123 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1205674007124 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205674007125 tetramer interface [polypeptide binding]; other site 1205674007126 TPP-binding site [chemical binding]; other site 1205674007127 heterodimer interface [polypeptide binding]; other site 1205674007128 phosphorylation loop region [posttranslational modification] 1205674007129 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205674007130 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1205674007131 putative active site [active] 1205674007132 putative catalytic site [active] 1205674007133 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674007134 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674007135 active site 1205674007136 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205674007137 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205674007138 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1205674007139 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1205674007140 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205674007141 carboxyltransferase (CT) interaction site; other site 1205674007142 biotinylation site [posttranslational modification]; other site 1205674007143 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205674007144 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205674007145 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205674007146 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1205674007147 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1205674007148 AMP-binding domain protein; Validated; Region: PRK08315 1205674007149 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674007150 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1205674007151 acyl-activating enzyme (AAE) consensus motif; other site 1205674007152 acyl-activating enzyme (AAE) consensus motif; other site 1205674007153 putative AMP binding site [chemical binding]; other site 1205674007154 putative active site [active] 1205674007155 putative CoA binding site [chemical binding]; other site 1205674007156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674007157 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1205674007158 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205674007159 classical (c) SDRs; Region: SDR_c; cd05233 1205674007160 NAD(P) binding site [chemical binding]; other site 1205674007161 active site 1205674007162 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1205674007163 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1205674007164 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1205674007165 catalytic site [active] 1205674007166 putative active site [active] 1205674007167 putative substrate binding site [chemical binding]; other site 1205674007168 dimer interface [polypeptide binding]; other site 1205674007169 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1205674007170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674007171 non-specific DNA binding site [nucleotide binding]; other site 1205674007172 salt bridge; other site 1205674007173 sequence-specific DNA binding site [nucleotide binding]; other site 1205674007174 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1205674007175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1205674007176 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205674007177 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205674007178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205674007179 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205674007180 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1205674007181 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205674007182 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1205674007183 catalytic triad [active] 1205674007184 hypothetical protein; Provisional; Region: PRK07907 1205674007185 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1205674007186 active site 1205674007187 metal binding site [ion binding]; metal-binding site 1205674007188 dimer interface [polypeptide binding]; other site 1205674007189 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1205674007190 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205674007191 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1205674007192 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205674007193 phosphate binding site [ion binding]; other site 1205674007194 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1205674007195 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1205674007196 putative active site [active] 1205674007197 putative catalytic site [active] 1205674007198 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205674007199 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205674007200 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1205674007201 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1205674007202 putative NAD(P) binding site [chemical binding]; other site 1205674007203 active site 1205674007204 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1205674007205 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1205674007206 active site 1205674007207 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1205674007208 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205674007209 putative active site [active] 1205674007210 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1205674007211 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1205674007212 Restriction endonuclease; Region: Mrr_cat; pfam04471 1205674007213 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15525680 1205674007214 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15525680 1205674007215 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205674007216 putative active site [active] 1205674007217 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1205674007218 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205674007219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674007220 catalytic residue [active] 1205674007221 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1205674007222 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1205674007223 putative RNA binding site [nucleotide binding]; other site 1205674007224 elongation factor P; Validated; Region: PRK00529 1205674007225 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1205674007226 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1205674007227 RNA binding site [nucleotide binding]; other site 1205674007228 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1205674007229 RNA binding site [nucleotide binding]; other site 1205674007230 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1205674007231 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1205674007232 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1205674007233 active site 1205674007234 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1205674007235 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1205674007236 trimer interface [polypeptide binding]; other site 1205674007237 active site 1205674007238 dimer interface [polypeptide binding]; other site 1205674007239 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1205674007240 active site 1205674007241 dimer interface [polypeptide binding]; other site 1205674007242 metal binding site [ion binding]; metal-binding site 1205674007243 shikimate kinase; Reviewed; Region: aroK; PRK00131 1205674007244 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1205674007245 ADP binding site [chemical binding]; other site 1205674007246 magnesium binding site [ion binding]; other site 1205674007247 putative shikimate binding site; other site 1205674007248 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1205674007249 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1205674007250 Tetramer interface [polypeptide binding]; other site 1205674007251 active site 1205674007252 FMN-binding site [chemical binding]; other site 1205674007253 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007254 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007255 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205674007256 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007257 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205674007258 putative active site [active] 1205674007259 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674007260 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205674007261 oligomeric interface; other site 1205674007262 putative active site [active] 1205674007263 homodimer interface [polypeptide binding]; other site 1205674007264 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1205674007265 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674007266 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1205674007267 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1205674007268 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1205674007269 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1205674007270 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1205674007271 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1205674007272 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1205674007273 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1205674007274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205674007275 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1205674007276 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1205674007277 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1205674007278 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1205674007279 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1205674007280 NAD(P) binding site [chemical binding]; other site 1205674007281 shikimate binding site; other site 1205674007282 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1205674007283 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1205674007284 dimerization interface [polypeptide binding]; other site 1205674007285 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1205674007286 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1205674007287 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1205674007288 motif 1; other site 1205674007289 active site 1205674007290 motif 2; other site 1205674007291 motif 3; other site 1205674007292 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1205674007293 DHHA1 domain; Region: DHHA1; pfam02272 1205674007294 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1205674007295 recombination factor protein RarA; Reviewed; Region: PRK13342 1205674007296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674007297 Walker A motif; other site 1205674007298 ATP binding site [chemical binding]; other site 1205674007299 Walker B motif; other site 1205674007300 arginine finger; other site 1205674007301 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1205674007302 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1205674007303 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1205674007304 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205674007305 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205674007306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205674007307 Walker A/P-loop; other site 1205674007308 ATP binding site [chemical binding]; other site 1205674007309 Q-loop/lid; other site 1205674007310 ABC transporter signature motif; other site 1205674007311 Walker B; other site 1205674007312 D-loop; other site 1205674007313 H-loop/switch region; other site 1205674007314 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674007315 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674007316 ligand binding site [chemical binding]; other site 1205674007317 flexible hinge region; other site 1205674007318 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674007319 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674007320 ligand binding site [chemical binding]; other site 1205674007321 flexible hinge region; other site 1205674007322 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205674007323 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1205674007324 active site 1205674007325 nucleophile elbow; other site 1205674007326 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205674007327 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205674007328 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205674007329 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1205674007330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1205674007331 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1205674007332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1205674007333 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1205674007334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1205674007335 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1205674007336 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205674007337 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205674007338 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1205674007339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1205674007340 Predicted membrane protein [Function unknown]; Region: COG4129 1205674007341 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1205674007342 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1205674007343 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1205674007344 dimer interface [polypeptide binding]; other site 1205674007345 anticodon binding site; other site 1205674007346 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1205674007347 homodimer interface [polypeptide binding]; other site 1205674007348 motif 1; other site 1205674007349 active site 1205674007350 motif 2; other site 1205674007351 GAD domain; Region: GAD; pfam02938 1205674007352 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205674007353 active site 1205674007354 motif 3; other site 1205674007355 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1205674007356 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1205674007357 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1205674007358 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205674007359 putative hydrophobic ligand binding site [chemical binding]; other site 1205674007360 protein interface [polypeptide binding]; other site 1205674007361 gate; other site 1205674007362 Predicted metalloprotease [General function prediction only]; Region: COG2321 1205674007363 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1205674007364 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205674007365 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205674007366 active site 1205674007367 metal binding site [ion binding]; metal-binding site 1205674007368 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1205674007369 haloalkane dehalogenase; Provisional; Region: PRK03592 1205674007370 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1205674007371 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1205674007372 motif 1; other site 1205674007373 dimer interface [polypeptide binding]; other site 1205674007374 active site 1205674007375 motif 2; other site 1205674007376 motif 3; other site 1205674007377 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1205674007378 anticodon binding site; other site 1205674007379 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205674007380 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205674007381 active site 1205674007382 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1205674007383 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205674007384 Zn2+ binding site [ion binding]; other site 1205674007385 Mg2+ binding site [ion binding]; other site 1205674007386 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205674007387 synthetase active site [active] 1205674007388 NTP binding site [chemical binding]; other site 1205674007389 metal binding site [ion binding]; metal-binding site 1205674007390 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1205674007391 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1205674007392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674007393 active site 1205674007394 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1205674007395 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205674007396 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1205674007397 Protein export membrane protein; Region: SecD_SecF; pfam02355 1205674007398 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1205674007399 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1205674007400 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1205674007401 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1205674007402 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205674007403 inhibitor-cofactor binding pocket; inhibition site 1205674007404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674007405 catalytic residue [active] 1205674007406 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205674007407 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674007408 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674007409 acyl-activating enzyme (AAE) consensus motif; other site 1205674007410 AMP binding site [chemical binding]; other site 1205674007411 active site 1205674007412 CoA binding site [chemical binding]; other site 1205674007413 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1205674007414 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1205674007415 putative NAD(P) binding site [chemical binding]; other site 1205674007416 active site 1205674007417 putative substrate binding site [chemical binding]; other site 1205674007418 PE family; Region: PE; pfam00934 1205674007419 PE family; Region: PE; pfam00934 1205674007420 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1205674007421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674007422 Walker A motif; other site 1205674007423 ATP binding site [chemical binding]; other site 1205674007424 Walker B motif; other site 1205674007425 arginine finger; other site 1205674007426 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1205674007427 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1205674007428 RuvA N terminal domain; Region: RuvA_N; pfam01330 1205674007429 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1205674007430 active site 1205674007431 putative DNA-binding cleft [nucleotide binding]; other site 1205674007432 dimer interface [polypeptide binding]; other site 1205674007433 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1205674007434 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1205674007435 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205674007436 putative active site [active] 1205674007437 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1205674007438 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1205674007439 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1205674007440 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1205674007441 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1205674007442 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1205674007443 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1205674007444 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674007445 hypothetical protein; Validated; Region: PRK00110 1205674007446 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1205674007447 predicted active site [active] 1205674007448 catalytic triad [active] 1205674007449 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1205674007450 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205674007451 active site 1205674007452 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1205674007453 catalytic triad [active] 1205674007454 dimer interface [polypeptide binding]; other site 1205674007455 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1205674007456 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1205674007457 active site 1205674007458 multimer interface [polypeptide binding]; other site 1205674007459 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1205674007460 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205674007461 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1205674007462 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674007463 PPE family; Region: PPE; pfam00823 1205674007464 PE-PPE domain; Region: PE-PPE; pfam08237 1205674007465 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674007466 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1205674007467 nudix motif; other site 1205674007468 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205674007469 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205674007470 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1205674007471 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1205674007472 putative acyl-acceptor binding pocket; other site 1205674007473 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205674007474 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1205674007475 nucleotide binding site/active site [active] 1205674007476 HIT family signature motif; other site 1205674007477 catalytic residue [active] 1205674007478 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1205674007479 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1205674007480 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1205674007481 active site 1205674007482 dimer interface [polypeptide binding]; other site 1205674007483 motif 1; other site 1205674007484 motif 2; other site 1205674007485 motif 3; other site 1205674007486 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1205674007487 anticodon binding site; other site 1205674007488 PE family; Region: PE; pfam00934 1205674007489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1205674007490 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205674007491 Helix-turn-helix domain; Region: HTH_20; pfam12840 1205674007492 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1205674007493 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205674007494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674007495 S-adenosylmethionine binding site [chemical binding]; other site 1205674007496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674007497 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674007498 Ligand Binding Site [chemical binding]; other site 1205674007499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674007500 Ligand Binding Site [chemical binding]; other site 1205674007501 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674007502 Ligand Binding Site [chemical binding]; other site 1205674007503 Universal stress protein family; Region: Usp; pfam00582 1205674007504 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1205674007505 active site 1205674007506 putative substrate binding region [chemical binding]; other site 1205674007507 FOG: CBS domain [General function prediction only]; Region: COG0517 1205674007508 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1205674007509 FOG: CBS domain [General function prediction only]; Region: COG0517 1205674007510 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1205674007511 peptide chain release factor 1; Provisional; Region: PRK04011 1205674007512 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1205674007513 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1205674007514 hypothetical protein; Reviewed; Region: PRK09588 1205674007515 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1205674007516 Hemerythrin-like domain; Region: Hr-like; cd12108 1205674007517 Fe binding site [ion binding]; other site 1205674007518 PE family; Region: PE; pfam00934 1205674007519 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1205674007520 P-loop motif; other site 1205674007521 ATP binding site [chemical binding]; other site 1205674007522 Chloramphenicol (Cm) binding site [chemical binding]; other site 1205674007523 catalytic residue [active] 1205674007524 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1205674007525 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1205674007526 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205674007527 anti sigma factor interaction site; other site 1205674007528 regulatory phosphorylation site [posttranslational modification]; other site 1205674007529 hypothetical protein; Provisional; Region: PRK02237 1205674007530 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674007531 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205674007532 putative DNA binding site [nucleotide binding]; other site 1205674007533 putative Zn2+ binding site [ion binding]; other site 1205674007534 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1205674007535 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205674007536 putative metal binding site [ion binding]; other site 1205674007537 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674007538 dimerization interface [polypeptide binding]; other site 1205674007539 putative DNA binding site [nucleotide binding]; other site 1205674007540 putative Zn2+ binding site [ion binding]; other site 1205674007541 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1205674007542 arsenical-resistance protein; Region: acr3; TIGR00832 1205674007543 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1205674007544 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205674007545 active site 1205674007546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674007547 active site 1205674007548 Int/Topo IB signature motif; other site 1205674007549 DNA binding site [nucleotide binding] 1205674007550 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674007551 Clp protease ATP binding subunit; Region: clpC; CHL00095 1205674007552 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1205674007553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674007554 Coenzyme A binding pocket [chemical binding]; other site 1205674007555 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1205674007556 hypothetical protein; Provisional; Region: PRK14059 1205674007557 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1205674007558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674007559 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205674007560 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1205674007561 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1205674007562 SelR domain; Region: SelR; pfam01641 1205674007563 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205674007564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674007565 S-adenosylmethionine binding site [chemical binding]; other site 1205674007566 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1205674007567 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1205674007568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674007569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674007570 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1205674007571 substrate binding site [chemical binding]; other site 1205674007572 active site 1205674007573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674007574 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205674007575 substrate binding site [chemical binding]; other site 1205674007576 oxyanion hole (OAH) forming residues; other site 1205674007577 trimer interface [polypeptide binding]; other site 1205674007578 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1205674007579 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1205674007580 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1205674007581 catalytic site [active] 1205674007582 putative active site [active] 1205674007583 putative substrate binding site [chemical binding]; other site 1205674007584 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1205674007585 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1205674007586 TPP-binding site; other site 1205674007587 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205674007588 PYR/PP interface [polypeptide binding]; other site 1205674007589 dimer interface [polypeptide binding]; other site 1205674007590 TPP binding site [chemical binding]; other site 1205674007591 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205674007592 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205674007593 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205674007594 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1205674007595 transmembrane helices; other site 1205674007596 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205674007597 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1205674007598 transmembrane helices; other site 1205674007599 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205674007600 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205674007601 Walker A/P-loop; other site 1205674007602 ATP binding site [chemical binding]; other site 1205674007603 Q-loop/lid; other site 1205674007604 ABC transporter signature motif; other site 1205674007605 Walker B; other site 1205674007606 D-loop; other site 1205674007607 H-loop/switch region; other site 1205674007608 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205674007609 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205674007610 TrkA-N domain; Region: TrkA_N; pfam02254 1205674007611 TrkA-C domain; Region: TrkA_C; pfam02080 1205674007612 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205674007613 TrkA-N domain; Region: TrkA_N; pfam02254 1205674007614 TrkA-C domain; Region: TrkA_C; pfam02080 1205674007615 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1205674007616 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1205674007617 generic binding surface II; other site 1205674007618 ssDNA binding site; other site 1205674007619 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1205674007620 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205674007621 trimer interface [polypeptide binding]; other site 1205674007622 active site 1205674007623 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1205674007624 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1205674007625 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205674007626 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205674007627 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1205674007628 active site 1205674007629 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205674007630 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205674007631 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205674007632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674007633 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205674007634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674007635 DNA binding residues [nucleotide binding] 1205674007636 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1205674007637 homotrimer interaction site [polypeptide binding]; other site 1205674007638 putative active site [active] 1205674007639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1205674007640 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1205674007641 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1205674007642 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1205674007643 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205674007644 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1205674007645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674007646 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205674007647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674007648 DNA binding residues [nucleotide binding] 1205674007649 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1205674007650 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1205674007651 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205674007652 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1205674007653 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1205674007654 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1205674007655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674007656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674007657 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205674007658 PAC2 family; Region: PAC2; pfam09754 1205674007659 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674007660 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1205674007661 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1205674007662 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1205674007663 heme-binding site [chemical binding]; other site 1205674007664 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1205674007665 ATP cone domain; Region: ATP-cone; pfam03477 1205674007666 LysM domain; Region: LysM; pfam01476 1205674007667 LexA repressor; Validated; Region: PRK00215 1205674007668 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1205674007669 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1205674007670 Catalytic site [active] 1205674007671 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1205674007672 LGFP repeat; Region: LGFP; pfam08310 1205674007673 LGFP repeat; Region: LGFP; pfam08310 1205674007674 LGFP repeat; Region: LGFP; pfam08310 1205674007675 LGFP repeat; Region: LGFP; pfam08310 1205674007676 LGFP repeat; Region: LGFP; pfam08310 1205674007677 Integral membrane protein TerC family; Region: TerC; cl10468 1205674007678 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674007679 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674007680 active site 1205674007681 GTPases [General function prediction only]; Region: HflX; COG2262 1205674007682 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1205674007683 HflX GTPase family; Region: HflX; cd01878 1205674007684 G1 box; other site 1205674007685 GTP/Mg2+ binding site [chemical binding]; other site 1205674007686 Switch I region; other site 1205674007687 G2 box; other site 1205674007688 G3 box; other site 1205674007689 Switch II region; other site 1205674007690 G4 box; other site 1205674007691 G5 box; other site 1205674007692 diaminopimelate epimerase; Region: DapF; TIGR00652 1205674007693 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205674007694 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205674007695 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1205674007696 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1205674007697 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1205674007698 active site 1205674007699 metal binding site [ion binding]; metal-binding site 1205674007700 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007701 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007702 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205674007703 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205674007704 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205674007705 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1205674007706 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1205674007707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674007708 FeS/SAM binding site; other site 1205674007709 TRAM domain; Region: TRAM; cl01282 1205674007710 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1205674007711 recA bacterial DNA recombination protein; Region: RecA; cl17211 1205674007712 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205674007713 thioester formation/cholesterol transfer; other site 1205674007714 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 1205674007715 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 1205674007716 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1205674007717 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205674007718 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1205674007719 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1205674007720 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1205674007721 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205674007722 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205674007723 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1205674007724 PE family; Region: PE; pfam00934 1205674007725 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1205674007726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674007727 non-specific DNA binding site [nucleotide binding]; other site 1205674007728 salt bridge; other site 1205674007729 sequence-specific DNA binding site [nucleotide binding]; other site 1205674007730 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205674007731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674007732 Coenzyme A binding pocket [chemical binding]; other site 1205674007733 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1205674007734 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674007735 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1205674007736 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205674007737 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1205674007738 classical (c) SDRs; Region: SDR_c; cd05233 1205674007739 NAD(P) binding site [chemical binding]; other site 1205674007740 active site 1205674007741 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674007742 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674007743 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1205674007744 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205674007745 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1205674007746 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1205674007747 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1205674007748 dimer interface [polypeptide binding]; other site 1205674007749 active site 1205674007750 catalytic residue [active] 1205674007751 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1205674007752 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1205674007753 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1205674007754 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205674007755 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205674007756 putative active site [active] 1205674007757 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205674007758 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205674007759 putative active site [active] 1205674007760 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1205674007761 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1205674007762 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1205674007763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1205674007764 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1205674007765 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1205674007766 folate binding site [chemical binding]; other site 1205674007767 NADP+ binding site [chemical binding]; other site 1205674007768 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1205674007769 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1205674007770 dimerization interface [polypeptide binding]; other site 1205674007771 active site 1205674007772 Dienelactone hydrolase family; Region: DLH; pfam01738 1205674007773 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1205674007774 classical (c) SDRs; Region: SDR_c; cd05233 1205674007775 NAD(P) binding site [chemical binding]; other site 1205674007776 active site 1205674007777 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674007778 PPE family; Region: PPE; pfam00823 1205674007779 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674007780 PE family; Region: PE; pfam00934 1205674007781 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674007782 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674007783 PPE family; Region: PPE; pfam00823 1205674007784 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1205674007785 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1205674007786 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1205674007787 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1205674007788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205674007789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674007790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205674007791 Coenzyme A binding pocket [chemical binding]; other site 1205674007792 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205674007793 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1205674007794 FMN-binding pocket [chemical binding]; other site 1205674007795 flavin binding motif; other site 1205674007796 phosphate binding motif [ion binding]; other site 1205674007797 beta-alpha-beta structure motif; other site 1205674007798 NAD binding pocket [chemical binding]; other site 1205674007799 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674007800 catalytic loop [active] 1205674007801 iron binding site [ion binding]; other site 1205674007802 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1205674007803 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1205674007804 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205674007805 hydrophobic ligand binding site; other site 1205674007806 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205674007807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674007808 putative DNA binding site [nucleotide binding]; other site 1205674007809 putative Zn2+ binding site [ion binding]; other site 1205674007810 AsnC family; Region: AsnC_trans_reg; pfam01037 1205674007811 alanine dehydrogenase; Region: alaDH; TIGR00518 1205674007812 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1205674007813 hexamer interface [polypeptide binding]; other site 1205674007814 ligand binding site [chemical binding]; other site 1205674007815 putative active site [active] 1205674007816 NAD(P) binding site [chemical binding]; other site 1205674007817 Nitronate monooxygenase; Region: NMO; pfam03060 1205674007818 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205674007819 FMN binding site [chemical binding]; other site 1205674007820 substrate binding site [chemical binding]; other site 1205674007821 putative catalytic residue [active] 1205674007822 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1205674007823 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1205674007824 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1205674007825 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1205674007826 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1205674007827 oligomer interface [polypeptide binding]; other site 1205674007828 RNA binding site [nucleotide binding]; other site 1205674007829 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1205674007830 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1205674007831 RNase E interface [polypeptide binding]; other site 1205674007832 trimer interface [polypeptide binding]; other site 1205674007833 active site 1205674007834 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1205674007835 putative nucleic acid binding region [nucleotide binding]; other site 1205674007836 G-X-X-G motif; other site 1205674007837 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1205674007838 RNA binding site [nucleotide binding]; other site 1205674007839 domain interface; other site 1205674007840 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1205674007841 16S/18S rRNA binding site [nucleotide binding]; other site 1205674007842 S13e-L30e interaction site [polypeptide binding]; other site 1205674007843 25S rRNA binding site [nucleotide binding]; other site 1205674007844 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1205674007845 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1205674007846 active site 1205674007847 Riboflavin kinase; Region: Flavokinase; pfam01687 1205674007848 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205674007849 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1205674007850 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1205674007851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674007852 putative DNA binding site [nucleotide binding]; other site 1205674007853 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205674007854 FeoA domain; Region: FeoA; pfam04023 1205674007855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674007856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674007857 active site 1205674007858 lipid-transfer protein; Provisional; Region: PRK08256 1205674007859 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205674007860 active site 1205674007861 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1205674007862 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1205674007863 RNA binding site [nucleotide binding]; other site 1205674007864 active site 1205674007865 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1205674007866 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1205674007867 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1205674007868 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205674007869 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205674007870 active site 1205674007871 metal binding site [ion binding]; metal-binding site 1205674007872 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1205674007873 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1205674007874 nucleophilic elbow; other site 1205674007875 catalytic triad; other site 1205674007876 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205674007877 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1205674007878 Predicted acyl esterases [General function prediction only]; Region: COG2936 1205674007879 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1205674007880 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205674007881 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1205674007882 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1205674007883 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674007884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674007885 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674007886 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674007887 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674007888 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007889 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007890 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007891 Evidence 4 : Homologs of previously reported genes of unknown function 1205674007892 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674007893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674007894 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674007895 Evidence 4 : Homologs of previously reported genes of unknown function; Product type e : enzyme 1205674007896 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1205674007897 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1205674007898 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1205674007899 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1205674007900 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1205674007901 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 1205674007902 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 1205674007903 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 1205674007904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205674007905 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1205674007906 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1205674007907 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1205674007908 putative active site [active] 1205674007909 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205674007910 enoyl-CoA hydratase; Provisional; Region: PRK06190 1205674007911 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674007912 substrate binding site [chemical binding]; other site 1205674007913 oxyanion hole (OAH) forming residues; other site 1205674007914 trimer interface [polypeptide binding]; other site 1205674007915 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205674007916 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205674007917 Walker A/P-loop; other site 1205674007918 ATP binding site [chemical binding]; other site 1205674007919 Q-loop/lid; other site 1205674007920 ABC transporter signature motif; other site 1205674007921 Walker B; other site 1205674007922 D-loop; other site 1205674007923 H-loop/switch region; other site 1205674007924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205674007925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205674007926 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205674007927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674007928 dimer interface [polypeptide binding]; other site 1205674007929 conserved gate region; other site 1205674007930 putative PBP binding loops; other site 1205674007931 ABC-ATPase subunit interface; other site 1205674007932 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1205674007933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674007934 dimer interface [polypeptide binding]; other site 1205674007935 conserved gate region; other site 1205674007936 putative PBP binding loops; other site 1205674007937 ABC-ATPase subunit interface; other site 1205674007938 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1205674007939 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1205674007940 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1205674007941 DHH family; Region: DHH; pfam01368 1205674007942 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1205674007943 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12368446, 12657046, 15525680; Product type pf : putative factor 1205674007944 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12368446, 12657046, 15525680; Product type pf : putative factor 1205674007945 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1205674007946 putative RNA binding cleft [nucleotide binding]; other site 1205674007947 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1205674007948 NusA N-terminal domain; Region: NusA_N; pfam08529 1205674007949 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1205674007950 RNA binding site [nucleotide binding]; other site 1205674007951 homodimer interface [polypeptide binding]; other site 1205674007952 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1205674007953 G-X-X-G motif; other site 1205674007954 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1205674007955 G-X-X-G motif; other site 1205674007956 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1205674007957 Sm and related proteins; Region: Sm_like; cl00259 1205674007958 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1205674007959 putative oligomer interface [polypeptide binding]; other site 1205674007960 putative RNA binding site [nucleotide binding]; other site 1205674007961 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1205674007962 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1205674007963 dinuclear metal binding motif [ion binding]; other site 1205674007964 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1205674007965 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1205674007966 dimer interface [polypeptide binding]; other site 1205674007967 motif 1; other site 1205674007968 active site 1205674007969 motif 2; other site 1205674007970 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1205674007971 putative deacylase active site [active] 1205674007972 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205674007973 active site 1205674007974 motif 3; other site 1205674007975 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1205674007976 anticodon binding site; other site 1205674007977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674007978 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205674007979 putative substrate translocation pore; other site 1205674007980 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1205674007981 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1205674007982 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1205674007983 homodimer interface [polypeptide binding]; other site 1205674007984 active site 1205674007985 SAM binding site [chemical binding]; other site 1205674007986 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1205674007987 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205674007988 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1205674007989 catalytic triad [active] 1205674007990 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1205674007991 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1205674007992 homodimer interface [polypeptide binding]; other site 1205674007993 Walker A motif; other site 1205674007994 ATP binding site [chemical binding]; other site 1205674007995 hydroxycobalamin binding site [chemical binding]; other site 1205674007996 Walker B motif; other site 1205674007997 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1205674007998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674007999 Walker A motif; other site 1205674008000 ATP binding site [chemical binding]; other site 1205674008001 Walker B motif; other site 1205674008002 arginine finger; other site 1205674008003 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1205674008004 metal ion-dependent adhesion site (MIDAS); other site 1205674008005 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1205674008006 malate:quinone oxidoreductase; Validated; Region: PRK05257 1205674008007 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1205674008008 PE family; Region: PE; pfam00934 1205674008009 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1205674008010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205674008011 mycothione reductase; Reviewed; Region: PRK07846 1205674008012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674008013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674008014 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205674008015 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1205674008016 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205674008017 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674008018 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205674008019 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205674008020 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205674008021 short chain dehydrogenase; Provisional; Region: PRK06057 1205674008022 classical (c) SDRs; Region: SDR_c; cd05233 1205674008023 NAD(P) binding site [chemical binding]; other site 1205674008024 active site 1205674008025 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205674008026 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205674008027 NAD(P) binding site [chemical binding]; other site 1205674008028 catalytic residues [active] 1205674008029 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1205674008030 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1205674008031 catalytic triad [active] 1205674008032 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205674008033 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205674008034 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205674008035 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205674008036 active site 1205674008037 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205674008038 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205674008039 putative active site [active] 1205674008040 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1205674008041 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205674008042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205674008043 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205674008044 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205674008045 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1205674008046 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1205674008047 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1205674008048 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205674008049 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205674008050 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1205674008051 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1205674008052 active site 1205674008053 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1205674008054 protein binding site [polypeptide binding]; other site 1205674008055 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1205674008056 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1205674008057 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1205674008058 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1205674008059 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674008060 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674008061 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1205674008062 Fasciclin domain; Region: Fasciclin; pfam02469 1205674008063 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205674008064 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205674008065 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1205674008066 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205674008067 catalytic residues [active] 1205674008068 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1205674008069 Fasciclin domain; Region: Fasciclin; pfam02469 1205674008070 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1205674008071 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205674008072 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1205674008073 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205674008074 catalytic residues [active] 1205674008075 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1205674008076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674008077 FeS/SAM binding site; other site 1205674008078 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1205674008079 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1205674008080 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1205674008081 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1205674008082 hinge region; other site 1205674008083 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1205674008084 putative nucleotide binding site [chemical binding]; other site 1205674008085 uridine monophosphate binding site [chemical binding]; other site 1205674008086 homohexameric interface [polypeptide binding]; other site 1205674008087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674008088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674008089 DNA binding site [nucleotide binding] 1205674008090 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205674008091 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205674008092 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205674008093 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1205674008094 catalytic residues [active] 1205674008095 catalytic nucleophile [active] 1205674008096 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205674008097 MarR family; Region: MarR; pfam01047 1205674008098 amidase; Provisional; Region: PRK07869 1205674008099 Amidase; Region: Amidase; pfam01425 1205674008100 elongation factor Ts; Provisional; Region: tsf; PRK09377 1205674008101 UBA/TS-N domain; Region: UBA; pfam00627 1205674008102 Elongation factor TS; Region: EF_TS; pfam00889 1205674008103 Elongation factor TS; Region: EF_TS; pfam00889 1205674008104 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1205674008105 rRNA interaction site [nucleotide binding]; other site 1205674008106 S8 interaction site; other site 1205674008107 putative laminin-1 binding site; other site 1205674008108 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205674008109 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205674008110 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008111 PPE family; Region: PPE; pfam00823 1205674008112 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674008113 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1205674008114 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674008115 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1205674008116 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674008117 active site 1205674008118 DNA binding site [nucleotide binding] 1205674008119 Int/Topo IB signature motif; other site 1205674008120 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205674008121 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205674008122 FAD binding pocket [chemical binding]; other site 1205674008123 FAD binding motif [chemical binding]; other site 1205674008124 phosphate binding motif [ion binding]; other site 1205674008125 NAD binding pocket [chemical binding]; other site 1205674008126 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1205674008127 DNA protecting protein DprA; Region: dprA; TIGR00732 1205674008128 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1205674008129 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205674008130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674008131 Walker A motif; other site 1205674008132 ATP binding site [chemical binding]; other site 1205674008133 Walker B motif; other site 1205674008134 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1205674008135 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1205674008136 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205674008137 hypothetical protein; Reviewed; Region: PRK12497 1205674008138 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1205674008139 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1205674008140 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1205674008141 putative molybdopterin cofactor binding site [chemical binding]; other site 1205674008142 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1205674008143 putative molybdopterin cofactor binding site; other site 1205674008144 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1205674008145 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1205674008146 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205674008147 active site 1205674008148 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1205674008149 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1205674008150 Catalytic site [active] 1205674008151 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1205674008152 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1205674008153 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205674008154 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1205674008155 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1205674008156 RimM N-terminal domain; Region: RimM; pfam01782 1205674008157 hypothetical protein; Provisional; Region: PRK02821 1205674008158 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1205674008159 G-X-X-G motif; other site 1205674008160 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1205674008161 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1205674008162 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1205674008163 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205674008164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674008165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674008166 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1205674008167 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1205674008168 active site 1205674008169 putative substrate binding pocket [chemical binding]; other site 1205674008170 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205674008171 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674008172 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674008173 active site 1205674008174 ATP binding site [chemical binding]; other site 1205674008175 substrate binding site [chemical binding]; other site 1205674008176 activation loop (A-loop); other site 1205674008177 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205674008178 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1205674008179 active site 1205674008180 signal recognition particle protein; Provisional; Region: PRK10867 1205674008181 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1205674008182 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1205674008183 P loop; other site 1205674008184 GTP binding site [chemical binding]; other site 1205674008185 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1205674008186 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205674008187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205674008188 ATP binding site [chemical binding]; other site 1205674008189 putative Mg++ binding site [ion binding]; other site 1205674008190 PII uridylyl-transferase; Provisional; Region: PRK03381 1205674008191 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1205674008192 metal binding triad [ion binding]; metal-binding site 1205674008193 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205674008194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205674008195 Zn2+ binding site [ion binding]; other site 1205674008196 Mg2+ binding site [ion binding]; other site 1205674008197 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1205674008198 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1205674008199 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1205674008200 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1205674008201 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1205674008202 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205674008203 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1205674008204 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205674008205 Walker A/P-loop; other site 1205674008206 ATP binding site [chemical binding]; other site 1205674008207 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1205674008208 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205674008209 ABC transporter signature motif; other site 1205674008210 Walker B; other site 1205674008211 D-loop; other site 1205674008212 H-loop/switch region; other site 1205674008213 acylphosphatase; Provisional; Region: PRK14422 1205674008214 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1205674008215 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1205674008216 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1205674008217 DNA binding site [nucleotide binding] 1205674008218 catalytic residue [active] 1205674008219 H2TH interface [polypeptide binding]; other site 1205674008220 putative catalytic residues [active] 1205674008221 turnover-facilitating residue; other site 1205674008222 intercalation triad [nucleotide binding]; other site 1205674008223 8OG recognition residue [nucleotide binding]; other site 1205674008224 putative reading head residues; other site 1205674008225 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205674008226 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205674008227 ribonuclease III; Reviewed; Region: rnc; PRK00102 1205674008228 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1205674008229 dimerization interface [polypeptide binding]; other site 1205674008230 active site 1205674008231 metal binding site [ion binding]; metal-binding site 1205674008232 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1205674008233 dsRNA binding site [nucleotide binding]; other site 1205674008234 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1205674008235 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1205674008236 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1205674008237 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205674008238 acyl-CoA synthetase; Validated; Region: PRK05850 1205674008239 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674008240 acyl-activating enzyme (AAE) consensus motif; other site 1205674008241 active site 1205674008242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674008243 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674008244 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674008245 active site 1205674008246 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205674008247 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674008248 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205674008249 NADP binding site [chemical binding]; other site 1205674008250 KR domain; Region: KR; pfam08659 1205674008251 active site 1205674008252 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674008253 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674008254 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205674008255 active site 1205674008256 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205674008257 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1205674008258 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205674008259 KR domain; Region: KR; pfam08659 1205674008260 NADP binding site [chemical binding]; other site 1205674008261 active site 1205674008262 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674008263 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674008264 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674008265 active site 1205674008266 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1205674008267 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674008268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674008269 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674008270 Enoylreductase; Region: PKS_ER; smart00829 1205674008271 NAD(P) binding site [chemical binding]; other site 1205674008272 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205674008273 KR domain; Region: KR; pfam08659 1205674008274 putative NADP binding site [chemical binding]; other site 1205674008275 active site 1205674008276 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674008277 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674008278 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674008279 active site 1205674008280 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674008281 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674008282 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205674008283 KR domain; Region: KR; pfam08659 1205674008284 putative NADP binding site [chemical binding]; other site 1205674008285 active site 1205674008286 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674008287 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674008288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674008289 active site 1205674008290 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674008291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205674008292 Condensation domain; Region: Condensation; pfam00668 1205674008293 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205674008294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674008295 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205674008296 Walker A/P-loop; other site 1205674008297 ATP binding site [chemical binding]; other site 1205674008298 Q-loop/lid; other site 1205674008299 ABC transporter signature motif; other site 1205674008300 Walker B; other site 1205674008301 D-loop; other site 1205674008302 H-loop/switch region; other site 1205674008303 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205674008304 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1205674008305 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1205674008306 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205674008307 acyltransferase PapA5; Provisional; Region: PRK09294 1205674008308 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674008309 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674008310 active site 1205674008311 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205674008312 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674008313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674008314 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674008315 Enoylreductase; Region: PKS_ER; smart00829 1205674008316 NAD(P) binding site [chemical binding]; other site 1205674008317 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205674008318 KR domain; Region: KR; pfam08659 1205674008319 putative NADP binding site [chemical binding]; other site 1205674008320 active site 1205674008321 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674008322 acyl-CoA synthetase; Validated; Region: PRK05850 1205674008323 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674008324 acyl-activating enzyme (AAE) consensus motif; other site 1205674008325 active site 1205674008326 MMPL family; Region: MMPL; pfam03176 1205674008327 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674008328 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674008329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674008330 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674008331 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674008332 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205674008333 Erythronolide synthase docking; Region: Docking; pfam08990 1205674008334 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674008335 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674008336 active site 1205674008337 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674008338 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674008339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674008340 Enoylreductase; Region: PKS_ER; smart00829 1205674008341 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674008342 NAD(P) binding site [chemical binding]; other site 1205674008343 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205674008344 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205674008345 putative NADP binding site [chemical binding]; other site 1205674008346 active site 1205674008347 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674008348 acyl-CoA synthetase; Validated; Region: PRK06060 1205674008349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674008350 acyl-activating enzyme (AAE) consensus motif; other site 1205674008351 AMP binding site [chemical binding]; other site 1205674008352 active site 1205674008353 CoA binding site [chemical binding]; other site 1205674008354 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674008355 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1205674008356 acyl-CoA synthetase; Validated; Region: PRK05850 1205674008357 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674008358 acyl-activating enzyme (AAE) consensus motif; other site 1205674008359 active site 1205674008360 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205674008361 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674008362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674008363 S-adenosylmethionine binding site [chemical binding]; other site 1205674008364 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1205674008365 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205674008366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674008367 S-adenosylmethionine binding site [chemical binding]; other site 1205674008368 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205674008369 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1205674008370 metal-binding site 1205674008371 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205674008372 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205674008373 active site 1205674008374 TDP-binding site; other site 1205674008375 acceptor substrate-binding pocket; other site 1205674008376 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1205674008377 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205674008378 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205674008379 Predicted permease; Region: DUF318; pfam03773 1205674008380 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1205674008381 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1205674008382 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1205674008383 putative active site [active] 1205674008384 putative substrate binding site [chemical binding]; other site 1205674008385 putative cosubstrate binding site; other site 1205674008386 catalytic site [active] 1205674008387 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1205674008388 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1205674008389 active site 1205674008390 (T/H)XGH motif; other site 1205674008391 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1205674008392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674008393 S-adenosylmethionine binding site [chemical binding]; other site 1205674008394 pyruvate carboxylase; Reviewed; Region: PRK12999 1205674008395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205674008396 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205674008397 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205674008398 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1205674008399 active site 1205674008400 catalytic residues [active] 1205674008401 metal binding site [ion binding]; metal-binding site 1205674008402 homodimer binding site [polypeptide binding]; other site 1205674008403 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205674008404 carboxyltransferase (CT) interaction site; other site 1205674008405 biotinylation site [posttranslational modification]; other site 1205674008406 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1205674008407 putative active site [active] 1205674008408 redox center [active] 1205674008409 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1205674008410 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1205674008411 catalytic residues [active] 1205674008412 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205674008413 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674008414 substrate binding pocket [chemical binding]; other site 1205674008415 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1205674008416 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205674008417 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205674008418 active site 1205674008419 catalytic tetrad [active] 1205674008420 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1205674008421 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1205674008422 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1205674008423 generic binding surface II; other site 1205674008424 ssDNA binding site; other site 1205674008425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674008426 ATP binding site [chemical binding]; other site 1205674008427 putative Mg++ binding site [ion binding]; other site 1205674008428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674008429 nucleotide binding region [chemical binding]; other site 1205674008430 ATP-binding site [chemical binding]; other site 1205674008431 DAK2 domain; Region: Dak2; cl03685 1205674008432 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1205674008433 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205674008434 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1205674008435 ligand binding site [chemical binding]; other site 1205674008436 active site 1205674008437 UGI interface [polypeptide binding]; other site 1205674008438 catalytic site [active] 1205674008439 thiamine monophosphate kinase; Provisional; Region: PRK05731 1205674008440 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1205674008441 ATP binding site [chemical binding]; other site 1205674008442 dimerization interface [polypeptide binding]; other site 1205674008443 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205674008444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674008445 Probable transposase; Region: OrfB_IS605; pfam01385 1205674008446 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205674008447 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1205674008448 catalytic residues [active] 1205674008449 catalytic nucleophile [active] 1205674008450 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1205674008451 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1205674008452 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1205674008453 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1205674008454 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1205674008455 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205674008456 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1205674008457 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1205674008458 polyphosphate kinase; Provisional; Region: PRK05443 1205674008459 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1205674008460 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1205674008461 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1205674008462 putative domain interface [polypeptide binding]; other site 1205674008463 putative active site [active] 1205674008464 catalytic site [active] 1205674008465 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1205674008466 putative domain interface [polypeptide binding]; other site 1205674008467 putative active site [active] 1205674008468 catalytic site [active] 1205674008469 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1205674008470 active site 1205674008471 Ap6A binding site [chemical binding]; other site 1205674008472 nudix motif; other site 1205674008473 metal binding site [ion binding]; metal-binding site 1205674008474 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674008475 catalytic core [active] 1205674008476 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1205674008477 IHF - DNA interface [nucleotide binding]; other site 1205674008478 IHF dimer interface [polypeptide binding]; other site 1205674008479 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1205674008480 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1205674008481 substrate binding site [chemical binding]; other site 1205674008482 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1205674008483 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1205674008484 substrate binding site [chemical binding]; other site 1205674008485 ligand binding site [chemical binding]; other site 1205674008486 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205674008487 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205674008488 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205674008489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674008490 S-adenosylmethionine binding site [chemical binding]; other site 1205674008491 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1205674008492 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205674008493 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1205674008494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674008495 active site 1205674008496 HIGH motif; other site 1205674008497 nucleotide binding site [chemical binding]; other site 1205674008498 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1205674008499 active site 1205674008500 KMSKS motif; other site 1205674008501 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1205674008502 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1205674008503 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205674008504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674008505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205674008506 putative substrate translocation pore; other site 1205674008507 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1205674008508 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1205674008509 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1205674008510 ligand binding site [chemical binding]; other site 1205674008511 NAD binding site [chemical binding]; other site 1205674008512 dimerization interface [polypeptide binding]; other site 1205674008513 catalytic site [active] 1205674008514 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1205674008515 putative L-serine binding site [chemical binding]; other site 1205674008516 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205674008517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674008518 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674008519 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674008520 active site 1205674008521 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1205674008522 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1205674008523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674008524 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205674008525 Walker A/P-loop; other site 1205674008526 ATP binding site [chemical binding]; other site 1205674008527 Q-loop/lid; other site 1205674008528 ABC transporter signature motif; other site 1205674008529 Walker B; other site 1205674008530 D-loop; other site 1205674008531 H-loop/switch region; other site 1205674008532 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1205674008533 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1205674008534 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1205674008535 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1205674008536 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1205674008537 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1205674008538 putative valine binding site [chemical binding]; other site 1205674008539 dimer interface [polypeptide binding]; other site 1205674008540 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1205674008541 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1205674008542 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205674008543 PYR/PP interface [polypeptide binding]; other site 1205674008544 dimer interface [polypeptide binding]; other site 1205674008545 TPP binding site [chemical binding]; other site 1205674008546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205674008547 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1205674008548 TPP-binding site [chemical binding]; other site 1205674008549 dimer interface [polypeptide binding]; other site 1205674008550 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205674008551 Predicted membrane protein [Function unknown]; Region: COG2259 1205674008552 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1205674008553 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1205674008554 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1205674008555 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1205674008556 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1205674008557 GatB domain; Region: GatB_Yqey; smart00845 1205674008558 6-phosphofructokinase; Provisional; Region: PRK03202 1205674008559 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1205674008560 active site 1205674008561 ADP/pyrophosphate binding site [chemical binding]; other site 1205674008562 dimerization interface [polypeptide binding]; other site 1205674008563 allosteric effector site; other site 1205674008564 fructose-1,6-bisphosphate binding site; other site 1205674008565 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205674008566 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1205674008567 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1205674008568 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1205674008569 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1205674008570 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1205674008571 nucleotide binding pocket [chemical binding]; other site 1205674008572 K-X-D-G motif; other site 1205674008573 catalytic site [active] 1205674008574 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1205674008575 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1205674008576 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1205674008577 Dimer interface [polypeptide binding]; other site 1205674008578 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1205674008579 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674008580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205674008581 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008582 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1205674008583 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1205674008584 Ligand Binding Site [chemical binding]; other site 1205674008585 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1205674008586 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1205674008587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674008588 catalytic residue [active] 1205674008589 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674008590 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205674008591 putative acyl-acceptor binding pocket; other site 1205674008592 Putative hemolysin [General function prediction only]; Region: COG3176 1205674008593 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1205674008594 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1205674008595 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1205674008596 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1205674008597 Ligand binding site [chemical binding]; other site 1205674008598 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1205674008599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674008600 S-adenosylmethionine binding site [chemical binding]; other site 1205674008601 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1205674008602 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1205674008603 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1205674008604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205674008605 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205674008606 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205674008607 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205674008608 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1205674008609 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1205674008610 trimer interface [polypeptide binding]; other site 1205674008611 active site 1205674008612 substrate binding site [chemical binding]; other site 1205674008613 CoA binding site [chemical binding]; other site 1205674008614 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1205674008615 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1205674008616 active site 1205674008617 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1205674008618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674008619 S-adenosylmethionine binding site [chemical binding]; other site 1205674008620 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674008621 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205674008622 substrate binding site [chemical binding]; other site 1205674008623 oxyanion hole (OAH) forming residues; other site 1205674008624 trimer interface [polypeptide binding]; other site 1205674008625 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1205674008626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674008627 Walker A/P-loop; other site 1205674008628 ATP binding site [chemical binding]; other site 1205674008629 Q-loop/lid; other site 1205674008630 ABC transporter signature motif; other site 1205674008631 Walker B; other site 1205674008632 D-loop; other site 1205674008633 H-loop/switch region; other site 1205674008634 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1205674008635 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1205674008636 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205674008637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674008638 motif II; other site 1205674008639 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1205674008640 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1205674008641 Binuclear center (active site) [active] 1205674008642 K-pathway; other site 1205674008643 Putative proton exit pathway; other site 1205674008644 Putative water exit pathway; other site 1205674008645 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1205674008646 D-pathway; other site 1205674008647 Low-spin heme binding site [chemical binding]; other site 1205674008648 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1205674008649 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205674008650 siderophore binding site; other site 1205674008651 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1205674008652 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1205674008653 putative NAD(P) binding site [chemical binding]; other site 1205674008654 putative substrate binding site [chemical binding]; other site 1205674008655 catalytic Zn binding site [ion binding]; other site 1205674008656 structural Zn binding site [ion binding]; other site 1205674008657 dimer interface [polypeptide binding]; other site 1205674008658 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1205674008659 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1205674008660 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1205674008661 dimer interface [polypeptide binding]; other site 1205674008662 putative radical transfer pathway; other site 1205674008663 diiron center [ion binding]; other site 1205674008664 tyrosyl radical; other site 1205674008665 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674008666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205674008667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674008668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674008669 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1205674008670 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1205674008671 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1205674008672 active site 1205674008673 dimer interface [polypeptide binding]; other site 1205674008674 catalytic residues [active] 1205674008675 effector binding site; other site 1205674008676 R2 peptide binding site; other site 1205674008677 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1205674008678 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1205674008679 catalytic residues [active] 1205674008680 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205674008681 Predicted flavoprotein [General function prediction only]; Region: COG0431 1205674008682 DNA polymerase IV; Validated; Region: PRK03352 1205674008683 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1205674008684 active site 1205674008685 DNA binding site [nucleotide binding] 1205674008686 short chain dehydrogenase; Provisional; Region: PRK07832 1205674008687 classical (c) SDRs; Region: SDR_c; cd05233 1205674008688 NAD(P) binding site [chemical binding]; other site 1205674008689 active site 1205674008690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674008691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674008692 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674008693 Cytochrome P450; Region: p450; cl12078 1205674008694 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205674008695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674008696 DNA-binding site [nucleotide binding]; DNA binding site 1205674008697 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1205674008698 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205674008699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205674008700 DNA-binding site [nucleotide binding]; DNA binding site 1205674008701 FCD domain; Region: FCD; pfam07729 1205674008702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674008703 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205674008704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674008705 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674008706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674008707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674008708 active site 1205674008709 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1205674008710 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1205674008711 active site 1205674008712 DNA binding site [nucleotide binding] 1205674008713 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1205674008714 DNA binding site [nucleotide binding] 1205674008715 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1205674008716 Carbon starvation protein CstA; Region: CstA; pfam02554 1205674008717 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1205674008718 Predicted membrane protein [Function unknown]; Region: COG2259 1205674008719 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1205674008720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205674008721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674008722 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674008723 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1205674008724 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1205674008725 active site 1205674008726 substrate binding site [chemical binding]; other site 1205674008727 metal binding site [ion binding]; metal-binding site 1205674008728 camphor resistance protein CrcB; Provisional; Region: PRK14216 1205674008729 camphor resistance protein CrcB; Provisional; Region: PRK14228 1205674008730 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1205674008731 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1205674008732 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1205674008733 Evidence 5 : No homology to any previously reported sequences; PubMedId : 12657046 1205674008734 Evidence 4 : Homologs of previously reported genes of unknown function 1205674008735 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1205674008736 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674008737 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674008738 active site 1205674008739 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205674008740 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205674008741 putative hydrophobic ligand binding site [chemical binding]; other site 1205674008742 protein interface [polypeptide binding]; other site 1205674008743 gate; other site 1205674008744 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205674008745 Sulfatase; Region: Sulfatase; pfam00884 1205674008746 Evidence 4 : Homologs of previously reported genes of unknown function 1205674008747 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674008748 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674008749 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205674008750 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205674008751 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205674008752 active site 1205674008753 ATP binding site [chemical binding]; other site 1205674008754 substrate binding site [chemical binding]; other site 1205674008755 activation loop (A-loop); other site 1205674008756 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1205674008757 AAA ATPase domain; Region: AAA_16; pfam13191 1205674008758 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 1205674008759 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205674008760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205674008761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205674008762 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674008763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205674008764 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674008765 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1205674008766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674008767 NAD(P) binding site [chemical binding]; other site 1205674008768 active site 1205674008769 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1205674008770 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205674008771 NAD binding site [chemical binding]; other site 1205674008772 catalytic Zn binding site [ion binding]; other site 1205674008773 substrate binding site [chemical binding]; other site 1205674008774 structural Zn binding site [ion binding]; other site 1205674008775 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674008776 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674008777 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674008778 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674008779 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1205674008780 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1205674008781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674008782 acyl-activating enzyme (AAE) consensus motif; other site 1205674008783 AMP binding site [chemical binding]; other site 1205674008784 active site 1205674008785 CoA binding site [chemical binding]; other site 1205674008786 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1205674008787 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205674008788 Patatin-like phospholipase; Region: Patatin; pfam01734 1205674008789 Protein of unknown function (DUF808); Region: DUF808; cl01002 1205674008790 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1205674008791 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674008792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674008793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674008794 active site 1205674008795 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205674008796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674008797 dimerization interface [polypeptide binding]; other site 1205674008798 putative DNA binding site [nucleotide binding]; other site 1205674008799 putative Zn2+ binding site [ion binding]; other site 1205674008800 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1205674008801 PE family; Region: PE; pfam00934 1205674008802 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674008803 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205674008804 PE family; Region: PE; pfam00934 1205674008805 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674008806 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205674008807 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205674008808 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205674008809 putative active site [active] 1205674008810 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1205674008811 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205674008812 active site 1205674008813 catalytic site [active] 1205674008814 substrate binding site [chemical binding]; other site 1205674008815 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674008816 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674008817 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674008818 active site 1205674008819 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674008820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674008821 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674008822 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674008823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674008824 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674008825 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674008826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674008827 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674008828 PemK-like protein; Region: PemK; pfam02452 1205674008829 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205674008830 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205674008831 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205674008832 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1205674008833 SmpB-tmRNA interface; other site 1205674008834 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1205674008835 FtsX-like permease family; Region: FtsX; pfam02687 1205674008836 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205674008837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205674008838 Walker A/P-loop; other site 1205674008839 ATP binding site [chemical binding]; other site 1205674008840 Q-loop/lid; other site 1205674008841 ABC transporter signature motif; other site 1205674008842 Walker B; other site 1205674008843 D-loop; other site 1205674008844 H-loop/switch region; other site 1205674008845 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1205674008846 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1205674008847 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1205674008848 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205674008849 RF-1 domain; Region: RF-1; pfam00472 1205674008850 ferredoxin-NADP+ reductase; Region: PLN02852 1205674008851 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674008852 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674008853 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1205674008854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674008855 FeS/SAM binding site; other site 1205674008856 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205674008857 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205674008858 aromatic arch; other site 1205674008859 DCoH dimer interaction site [polypeptide binding]; other site 1205674008860 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205674008861 DCoH tetramer interaction site [polypeptide binding]; other site 1205674008862 substrate binding site [chemical binding]; other site 1205674008863 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205674008864 trimer interface [polypeptide binding]; other site 1205674008865 dimer interface [polypeptide binding]; other site 1205674008866 putative active site [active] 1205674008867 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1205674008868 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205674008869 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205674008870 nucleoside/Zn binding site; other site 1205674008871 dimer interface [polypeptide binding]; other site 1205674008872 catalytic motif [active] 1205674008873 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1205674008874 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1205674008875 ATP binding site [chemical binding]; other site 1205674008876 substrate interface [chemical binding]; other site 1205674008877 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205674008878 active site residue [active] 1205674008879 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205674008880 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205674008881 active site residue [active] 1205674008882 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205674008883 active site residue [active] 1205674008884 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1205674008885 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205674008886 MoaE homodimer interface [polypeptide binding]; other site 1205674008887 MoaD interaction [polypeptide binding]; other site 1205674008888 active site residues [active] 1205674008889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674008890 S-adenosylmethionine binding site [chemical binding]; other site 1205674008891 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674008892 Cytochrome P450; Region: p450; cl12078 1205674008893 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205674008894 MULE transposase domain; Region: MULE; pfam10551 1205674008895 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674008896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674008897 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674008898 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674008899 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205674008900 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205674008901 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008902 PPE family; Region: PPE; pfam00823 1205674008903 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205674008904 Integrase core domain; Region: rve; pfam00665 1205674008905 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674008906 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674008907 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205674008908 dimer interface [polypeptide binding]; other site 1205674008909 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205674008910 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205674008911 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205674008912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205674008913 Histidine kinase; Region: HisKA_3; pfam07730 1205674008914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674008915 ATP binding site [chemical binding]; other site 1205674008916 Mg2+ binding site [ion binding]; other site 1205674008917 G-X-G motif; other site 1205674008918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205674008919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674008920 active site 1205674008921 phosphorylation site [posttranslational modification] 1205674008922 intermolecular recognition site; other site 1205674008923 dimerization interface [polypeptide binding]; other site 1205674008924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205674008925 DNA binding residues [nucleotide binding] 1205674008926 dimerization interface [polypeptide binding]; other site 1205674008927 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205674008928 Ligand Binding Site [chemical binding]; other site 1205674008929 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008930 PPE family; Region: PPE; pfam00823 1205674008931 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674008932 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008933 PPE family; Region: PPE; pfam00823 1205674008934 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674008935 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205674008936 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1205674008937 active site 1205674008938 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1205674008939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674008940 FeS/SAM binding site; other site 1205674008941 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674008942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674008943 active site 1205674008944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674008945 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674008946 active site 1205674008947 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205674008948 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1205674008949 NAD(P) binding site [chemical binding]; other site 1205674008950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674008951 active site 1205674008952 phosphorylation site [posttranslational modification] 1205674008953 intermolecular recognition site; other site 1205674008954 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008955 PPE family; Region: PPE; pfam00823 1205674008956 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1205674008957 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1205674008958 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1205674008959 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1205674008960 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1205674008961 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1205674008962 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1205674008963 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1205674008964 putative dimer interface [polypeptide binding]; other site 1205674008965 [2Fe-2S] cluster binding site [ion binding]; other site 1205674008966 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1205674008967 SLBB domain; Region: SLBB; pfam10531 1205674008968 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1205674008969 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1205674008970 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674008971 catalytic loop [active] 1205674008972 iron binding site [ion binding]; other site 1205674008973 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1205674008974 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674008975 molybdopterin cofactor binding site; other site 1205674008976 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205674008977 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1205674008978 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1205674008979 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1205674008980 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1205674008981 4Fe-4S binding domain; Region: Fer4; pfam00037 1205674008982 4Fe-4S binding domain; Region: Fer4; pfam00037 1205674008983 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1205674008984 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1205674008985 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1205674008986 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1205674008987 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205674008988 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1205674008989 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205674008990 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1205674008991 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205674008992 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008993 PPE family; Region: PPE; pfam00823 1205674008994 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674008995 PPE family; Region: PPE; pfam00823 1205674008996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674008997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674008998 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1205674008999 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1205674009000 [2Fe-2S] cluster binding site [ion binding]; other site 1205674009001 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1205674009002 putative alpha subunit interface [polypeptide binding]; other site 1205674009003 putative active site [active] 1205674009004 putative substrate binding site [chemical binding]; other site 1205674009005 Fe binding site [ion binding]; other site 1205674009006 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205674009007 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205674009008 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205674009009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674009010 Walker A motif; other site 1205674009011 ATP binding site [chemical binding]; other site 1205674009012 Walker B motif; other site 1205674009013 arginine finger; other site 1205674009014 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1205674009015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674009016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674009017 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1205674009018 putative active site [active] 1205674009019 putative substrate binding site [chemical binding]; other site 1205674009020 ATP binding site [chemical binding]; other site 1205674009021 Phosphotransferase enzyme family; Region: APH; pfam01636 1205674009022 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1205674009023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674009024 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205674009025 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674009026 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205674009027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674009028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674009029 short chain dehydrogenase; Validated; Region: PRK08264 1205674009030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674009031 NAD(P) binding site [chemical binding]; other site 1205674009032 active site 1205674009033 amidase; Provisional; Region: PRK06170 1205674009034 Amidase; Region: Amidase; pfam01425 1205674009035 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674009036 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674009037 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205674009038 Domain of unknown function (DUF385); Region: DUF385; cl04387 1205674009039 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674009040 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205674009041 AAA domain; Region: AAA_14; pfam13173 1205674009042 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1205674009043 putative active site [active] 1205674009044 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205674009045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1205674009046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205674009047 non-specific DNA binding site [nucleotide binding]; other site 1205674009048 salt bridge; other site 1205674009049 sequence-specific DNA binding site [nucleotide binding]; other site 1205674009050 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1205674009051 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674009052 hypothetical protein; Validated; Region: PRK00068 1205674009053 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1205674009054 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1205674009055 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1205674009056 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205674009057 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1205674009058 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1205674009059 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205674009060 ABC1 family; Region: ABC1; pfam03109 1205674009061 Phosphotransferase enzyme family; Region: APH; pfam01636 1205674009062 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1205674009063 active site 1205674009064 ATP binding site [chemical binding]; other site 1205674009065 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205674009066 Part of AAA domain; Region: AAA_19; pfam13245 1205674009067 Family description; Region: UvrD_C_2; pfam13538 1205674009068 HRDC domain; Region: HRDC; pfam00570 1205674009069 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1205674009070 catalytic residues [active] 1205674009071 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1205674009072 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1205674009073 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1205674009074 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1205674009075 putative NADH binding site [chemical binding]; other site 1205674009076 putative active site [active] 1205674009077 nudix motif; other site 1205674009078 putative metal binding site [ion binding]; other site 1205674009079 Ion channel; Region: Ion_trans_2; pfam07885 1205674009080 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205674009081 TrkA-N domain; Region: TrkA_N; pfam02254 1205674009082 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205674009083 Part of AAA domain; Region: AAA_19; pfam13245 1205674009084 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1205674009085 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205674009086 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205674009087 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205674009088 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205674009089 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205674009090 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205674009091 active site 1205674009092 DNA binding site [nucleotide binding] 1205674009093 TIGR02569 family protein; Region: TIGR02569_actnb 1205674009094 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1205674009095 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1205674009096 ATP binding site [chemical binding]; other site 1205674009097 substrate interface [chemical binding]; other site 1205674009098 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205674009099 active site residue [active] 1205674009100 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1205674009101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674009102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674009103 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1205674009104 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1205674009105 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205674009106 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205674009107 ATP binding site [chemical binding]; other site 1205674009108 Mg++ binding site [ion binding]; other site 1205674009109 motif III; other site 1205674009110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674009111 nucleotide binding region [chemical binding]; other site 1205674009112 ATP-binding site [chemical binding]; other site 1205674009113 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205674009114 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674009115 P-loop; other site 1205674009116 Magnesium ion binding site [ion binding]; other site 1205674009117 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674009118 Magnesium ion binding site [ion binding]; other site 1205674009119 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674009120 catalytic core [active] 1205674009121 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1205674009122 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205674009123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205674009124 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1205674009125 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1205674009126 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205674009127 Transcription factor WhiB; Region: Whib; pfam02467 1205674009128 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1205674009129 PAS domain S-box; Region: sensory_box; TIGR00229 1205674009130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1205674009131 Histidine kinase; Region: HisKA_2; pfam07568 1205674009132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674009133 ATP binding site [chemical binding]; other site 1205674009134 Mg2+ binding site [ion binding]; other site 1205674009135 G-X-G motif; other site 1205674009136 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205674009137 carboxyltransferase (CT) interaction site; other site 1205674009138 biotinylation site [posttranslational modification]; other site 1205674009139 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1205674009140 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674009141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674009142 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674009143 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1205674009144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674009145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674009146 DNA binding residues [nucleotide binding] 1205674009147 short chain dehydrogenase; Provisional; Region: PRK08278 1205674009148 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1205674009149 NAD(P) binding site [chemical binding]; other site 1205674009150 homodimer interface [polypeptide binding]; other site 1205674009151 active site 1205674009152 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1205674009153 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205674009154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205674009155 Coenzyme A binding pocket [chemical binding]; other site 1205674009156 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1205674009157 Phosphotransferase enzyme family; Region: APH; pfam01636 1205674009158 putative active site [active] 1205674009159 putative substrate binding site [chemical binding]; other site 1205674009160 ATP binding site [chemical binding]; other site 1205674009161 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1205674009162 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1205674009163 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1205674009164 hinge; other site 1205674009165 active site 1205674009166 Predicted GTPases [General function prediction only]; Region: COG1162 1205674009167 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1205674009168 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1205674009169 GTP/Mg2+ binding site [chemical binding]; other site 1205674009170 G4 box; other site 1205674009171 G5 box; other site 1205674009172 G1 box; other site 1205674009173 Switch I region; other site 1205674009174 G2 box; other site 1205674009175 G3 box; other site 1205674009176 Switch II region; other site 1205674009177 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205674009178 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1205674009179 putative di-iron ligands [ion binding]; other site 1205674009180 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1205674009181 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205674009182 FAD binding pocket [chemical binding]; other site 1205674009183 FAD binding motif [chemical binding]; other site 1205674009184 phosphate binding motif [ion binding]; other site 1205674009185 beta-alpha-beta structure motif; other site 1205674009186 NAD binding pocket [chemical binding]; other site 1205674009187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674009188 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1205674009189 catalytic loop [active] 1205674009190 iron binding site [ion binding]; other site 1205674009191 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1205674009192 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674009193 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674009194 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1205674009195 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1205674009196 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1205674009197 TrkA-C domain; Region: TrkA_C; pfam02080 1205674009198 Phospholipid methyltransferase; Region: PEMT; cl17370 1205674009199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674009200 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205674009201 putative substrate translocation pore; other site 1205674009202 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674009203 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674009204 ligand binding site [chemical binding]; other site 1205674009205 flexible hinge region; other site 1205674009206 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205674009207 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205674009208 nucleophile elbow; other site 1205674009209 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1205674009210 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1205674009211 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1205674009212 30S subunit binding site; other site 1205674009213 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1205674009214 active site 1205674009215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1205674009216 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205674009217 lipoprotein LpqB; Provisional; Region: PRK13616 1205674009218 Sporulation and spore germination; Region: Germane; pfam10646 1205674009219 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205674009220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674009221 dimerization interface [polypeptide binding]; other site 1205674009222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674009223 dimer interface [polypeptide binding]; other site 1205674009224 phosphorylation site [posttranslational modification] 1205674009225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674009226 ATP binding site [chemical binding]; other site 1205674009227 Mg2+ binding site [ion binding]; other site 1205674009228 G-X-G motif; other site 1205674009229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674009230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674009231 active site 1205674009232 phosphorylation site [posttranslational modification] 1205674009233 intermolecular recognition site; other site 1205674009234 dimerization interface [polypeptide binding]; other site 1205674009235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674009236 DNA binding site [nucleotide binding] 1205674009237 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1205674009238 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1205674009239 TMP-binding site; other site 1205674009240 ATP-binding site [chemical binding]; other site 1205674009241 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1205674009242 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1205674009243 homotetramer interface [polypeptide binding]; other site 1205674009244 ligand binding site [chemical binding]; other site 1205674009245 catalytic site [active] 1205674009246 NAD binding site [chemical binding]; other site 1205674009247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674009248 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1205674009249 Rubredoxin [Energy production and conversion]; Region: COG1773 1205674009250 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1205674009251 iron binding site [ion binding]; other site 1205674009252 Rubredoxin [Energy production and conversion]; Region: COG1773 1205674009253 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1205674009254 iron binding site [ion binding]; other site 1205674009255 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1205674009256 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1205674009257 Di-iron ligands [ion binding]; other site 1205674009258 amino acid transporter; Region: 2A0306; TIGR00909 1205674009259 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1205674009260 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1205674009261 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1205674009262 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205674009263 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205674009264 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1205674009265 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1205674009266 active site 1205674009267 substrate binding site [chemical binding]; other site 1205674009268 metal binding site [ion binding]; metal-binding site 1205674009269 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1205674009270 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1205674009271 Transcription factor WhiB; Region: Whib; pfam02467 1205674009272 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1205674009273 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1205674009274 phosphate binding site [ion binding]; other site 1205674009275 dimer interface [polypeptide binding]; other site 1205674009276 substrate binding site [chemical binding]; other site 1205674009277 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1205674009278 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1205674009279 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1205674009280 putative FMN binding site [chemical binding]; other site 1205674009281 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1205674009282 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205674009283 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1205674009284 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1205674009285 active site 1205674009286 Substrate binding site; other site 1205674009287 Mg++ binding site; other site 1205674009288 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1205674009289 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205674009290 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205674009291 Probable Catalytic site; other site 1205674009292 metal-binding site 1205674009293 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1205674009294 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1205674009295 NADP binding site [chemical binding]; other site 1205674009296 active site 1205674009297 putative substrate binding site [chemical binding]; other site 1205674009298 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205674009299 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205674009300 TIGR03089 family protein; Region: TIGR03089 1205674009301 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205674009302 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205674009303 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674009304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1205674009305 active site 1205674009306 motif I; other site 1205674009307 motif II; other site 1205674009308 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674009309 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674009310 active site 1205674009311 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759; Product type e : enzyme 1205674009312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205674009313 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009314 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009315 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1205674009316 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205674009317 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205674009318 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205674009319 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205674009320 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1205674009321 active site clefts [active] 1205674009322 zinc binding site [ion binding]; other site 1205674009323 dimer interface [polypeptide binding]; other site 1205674009324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674009325 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1205674009326 FAD binding site [chemical binding]; other site 1205674009327 homotetramer interface [polypeptide binding]; other site 1205674009328 substrate binding pocket [chemical binding]; other site 1205674009329 catalytic base [active] 1205674009330 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1205674009331 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1205674009332 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205674009333 Predicted membrane protein [Function unknown]; Region: COG2246 1205674009334 GtrA-like protein; Region: GtrA; pfam04138 1205674009335 Bacterial PH domain; Region: DUF304; pfam03703 1205674009336 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1205674009337 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1205674009338 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1205674009339 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205674009340 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205674009341 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205674009342 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1205674009343 Maf-like protein; Region: Maf; pfam02545 1205674009344 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1205674009345 active site 1205674009346 dimer interface [polypeptide binding]; other site 1205674009347 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205674009348 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205674009349 active site residue [active] 1205674009350 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205674009351 active site residue [active] 1205674009352 Fe-S metabolism associated domain; Region: SufE; cl00951 1205674009353 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205674009354 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205674009355 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1205674009356 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205674009357 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205674009358 carboxyltransferase (CT) interaction site; other site 1205674009359 biotinylation site [posttranslational modification]; other site 1205674009360 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1205674009361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674009362 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205674009363 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1205674009364 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1205674009365 L-lysine aminotransferase; Provisional; Region: PRK08297 1205674009366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205674009367 inhibitor-cofactor binding pocket; inhibition site 1205674009368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674009369 catalytic residue [active] 1205674009370 putative DNA binding site [nucleotide binding]; other site 1205674009371 dimerization interface [polypeptide binding]; other site 1205674009372 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205674009373 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205674009374 putative Zn2+ binding site [ion binding]; other site 1205674009375 AsnC family; Region: AsnC_trans_reg; pfam01037 1205674009376 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1205674009377 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1205674009378 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205674009379 tetrameric interface [polypeptide binding]; other site 1205674009380 NAD binding site [chemical binding]; other site 1205674009381 catalytic residues [active] 1205674009382 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205674009383 AAA domain; Region: AAA_14; pfam13173 1205674009384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674009385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674009386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674009387 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1205674009388 ATP binding site [chemical binding]; other site 1205674009389 putative Mg++ binding site [ion binding]; other site 1205674009390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674009391 nucleotide binding region [chemical binding]; other site 1205674009392 ATP-binding site [chemical binding]; other site 1205674009393 DEAD/H associated; Region: DEAD_assoc; pfam08494 1205674009394 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205674009395 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1205674009396 putative DNA binding site [nucleotide binding]; other site 1205674009397 catalytic residue [active] 1205674009398 putative H2TH interface [polypeptide binding]; other site 1205674009399 putative catalytic residues [active] 1205674009400 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205674009401 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1205674009402 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205674009403 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205674009404 Sulfatase; Region: Sulfatase; pfam00884 1205674009405 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1205674009406 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1205674009407 probable active site [active] 1205674009408 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1205674009409 PhoU domain; Region: PhoU; pfam01895 1205674009410 PhoU domain; Region: PhoU; pfam01895 1205674009411 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1205674009412 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1205674009413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674009414 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205674009415 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1205674009416 putative active site pocket [active] 1205674009417 dimerization interface [polypeptide binding]; other site 1205674009418 putative catalytic residue [active] 1205674009419 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1205674009420 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1205674009421 metal binding site [ion binding]; metal-binding site 1205674009422 putative dimer interface [polypeptide binding]; other site 1205674009423 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1205674009424 amidohydrolase; Region: amidohydrolases; TIGR01891 1205674009425 metal binding site [ion binding]; metal-binding site 1205674009426 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1205674009427 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1205674009428 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1205674009429 active site 1205674009430 substrate binding site [chemical binding]; other site 1205674009431 metal binding site [ion binding]; metal-binding site 1205674009432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674009433 active site 1205674009434 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205674009435 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674009436 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1205674009437 adenosine deaminase; Provisional; Region: PRK09358 1205674009438 active site 1205674009439 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1205674009440 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205674009441 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205674009442 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1205674009443 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1205674009444 active site 1205674009445 catalytic motif [active] 1205674009446 Zn binding site [ion binding]; other site 1205674009447 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1205674009448 putative Iron-sulfur protein interface [polypeptide binding]; other site 1205674009449 putative proximal heme binding site [chemical binding]; other site 1205674009450 putative SdhD-like interface [polypeptide binding]; other site 1205674009451 putative distal heme binding site [chemical binding]; other site 1205674009452 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1205674009453 putative Iron-sulfur protein interface [polypeptide binding]; other site 1205674009454 putative proximal heme binding site [chemical binding]; other site 1205674009455 putative SdhC-like subunit interface [polypeptide binding]; other site 1205674009456 putative distal heme binding site [chemical binding]; other site 1205674009457 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1205674009458 L-aspartate oxidase; Provisional; Region: PRK06175 1205674009459 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205674009460 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1205674009461 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1205674009462 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674009463 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205674009464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674009465 S-adenosylmethionine binding site [chemical binding]; other site 1205674009466 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205674009467 MoaE interaction surface [polypeptide binding]; other site 1205674009468 MoeB interaction surface [polypeptide binding]; other site 1205674009469 thiocarboxylated glycine; other site 1205674009470 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205674009471 MoaE homodimer interface [polypeptide binding]; other site 1205674009472 MoaD interaction [polypeptide binding]; other site 1205674009473 active site residues [active] 1205674009474 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205674009475 trimer interface [polypeptide binding]; other site 1205674009476 dimer interface [polypeptide binding]; other site 1205674009477 putative active site [active] 1205674009478 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205674009479 aromatic arch; other site 1205674009480 DCoH dimer interaction site [polypeptide binding]; other site 1205674009481 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205674009482 DCoH tetramer interaction site [polypeptide binding]; other site 1205674009483 substrate binding site [chemical binding]; other site 1205674009484 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1205674009485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674009486 FeS/SAM binding site; other site 1205674009487 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205674009488 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205674009489 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205674009490 DNA binding site [nucleotide binding] 1205674009491 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674009492 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674009493 phosphopeptide binding site; other site 1205674009494 Condensation domain; Region: Condensation; pfam00668 1205674009495 Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 12775759; Product type e : enzyme 1205674009496 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1205674009497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674009498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674009499 DNA binding residues [nucleotide binding] 1205674009500 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205674009501 hypothetical protein; Provisional; Region: PRK06541 1205674009502 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205674009503 inhibitor-cofactor binding pocket; inhibition site 1205674009504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674009505 catalytic residue [active] 1205674009506 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205674009507 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1205674009508 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1205674009509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674009510 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1205674009511 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1205674009512 active site 1205674009513 dimer interface [polypeptide binding]; other site 1205674009514 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674009515 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1205674009516 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205674009517 DNA binding residues [nucleotide binding] 1205674009518 dimer interface [polypeptide binding]; other site 1205674009519 metal binding site [ion binding]; metal-binding site 1205674009520 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1205674009521 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1205674009522 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1205674009523 active site 1205674009524 HIGH motif; other site 1205674009525 dimer interface [polypeptide binding]; other site 1205674009526 KMSKS motif; other site 1205674009527 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674009528 isocitrate dehydrogenase; Validated; Region: PRK08299 1205674009529 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1205674009530 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205674009531 homodimer interface [polypeptide binding]; other site 1205674009532 substrate-cofactor binding pocket; other site 1205674009533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674009534 catalytic residue [active] 1205674009535 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1205674009536 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1205674009537 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205674009538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674009539 S-adenosylmethionine binding site [chemical binding]; other site 1205674009540 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009541 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009542 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009543 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009544 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009545 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009546 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009547 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009548 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009549 Sec24-related protein; Provisional; Region: PTZ00395 1205674009550 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009551 PPE family; Region: PPE; pfam00823 1205674009552 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009553 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009554 PPE family; Region: PPE; pfam00823 1205674009555 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009556 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009557 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009558 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009559 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009560 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009561 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674009562 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009563 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674009564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674009565 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674009566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205674009567 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205674009568 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205674009569 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1205674009570 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1205674009571 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1205674009572 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1205674009573 homodimer interface [polypeptide binding]; other site 1205674009574 NADP binding site [chemical binding]; other site 1205674009575 substrate binding site [chemical binding]; other site 1205674009576 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205674009577 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1205674009578 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1205674009579 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1205674009580 active site 1205674009581 FMN binding site [chemical binding]; other site 1205674009582 substrate binding site [chemical binding]; other site 1205674009583 putative catalytic residue [active] 1205674009584 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205674009585 phosphate binding site [ion binding]; other site 1205674009586 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674009587 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205674009588 phosphopeptide binding site; other site 1205674009589 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205674009590 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205674009591 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205674009592 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205674009593 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205674009594 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205674009595 G1 box; other site 1205674009596 GTP/Mg2+ binding site [chemical binding]; other site 1205674009597 G2 box; other site 1205674009598 Switch I region; other site 1205674009599 G3 box; other site 1205674009600 Switch II region; other site 1205674009601 G4 box; other site 1205674009602 G5 box; other site 1205674009603 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205674009604 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1205674009605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205674009606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674009607 ATP binding site [chemical binding]; other site 1205674009608 Mg2+ binding site [ion binding]; other site 1205674009609 G-X-G motif; other site 1205674009610 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1205674009611 PE family; Region: PE; pfam00934 1205674009612 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1205674009613 FMN binding site [chemical binding]; other site 1205674009614 dimer interface [polypeptide binding]; other site 1205674009615 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 1205674009616 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1205674009617 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1205674009618 active site 1205674009619 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1205674009620 generic binding surface II; other site 1205674009621 generic binding surface I; other site 1205674009622 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674009623 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674009624 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1205674009625 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1205674009626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674009627 active site 1205674009628 motif I; other site 1205674009629 motif II; other site 1205674009630 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1205674009631 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674009632 substrate binding site [chemical binding]; other site 1205674009633 oxyanion hole (OAH) forming residues; other site 1205674009634 trimer interface [polypeptide binding]; other site 1205674009635 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205674009636 Amidase; Region: Amidase; pfam01425 1205674009637 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1205674009638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674009639 motif II; other site 1205674009640 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1205674009641 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1205674009642 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1205674009643 TPP-binding site [chemical binding]; other site 1205674009644 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1205674009645 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205674009646 PYR/PP interface [polypeptide binding]; other site 1205674009647 dimer interface [polypeptide binding]; other site 1205674009648 TPP binding site [chemical binding]; other site 1205674009649 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205674009650 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1205674009651 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1205674009652 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205674009653 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205674009654 substrate binding pocket [chemical binding]; other site 1205674009655 chain length determination region; other site 1205674009656 substrate-Mg2+ binding site; other site 1205674009657 catalytic residues [active] 1205674009658 aspartate-rich region 1; other site 1205674009659 active site lid residues [active] 1205674009660 aspartate-rich region 2; other site 1205674009661 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1205674009662 putative active site [active] 1205674009663 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205674009664 enoyl-CoA hydratase; Region: PLN02864 1205674009665 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205674009666 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1205674009667 dimer interaction site [polypeptide binding]; other site 1205674009668 substrate-binding tunnel; other site 1205674009669 active site 1205674009670 catalytic site [active] 1205674009671 substrate binding site [chemical binding]; other site 1205674009672 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674009673 short chain dehydrogenase; Provisional; Region: PRK07201 1205674009674 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1205674009675 putative NAD(P) binding site [chemical binding]; other site 1205674009676 active site 1205674009677 putative substrate binding site [chemical binding]; other site 1205674009678 classical (c) SDRs; Region: SDR_c; cd05233 1205674009679 NAD(P) binding site [chemical binding]; other site 1205674009680 active site 1205674009681 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674009682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674009683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674009684 S-adenosylmethionine binding site [chemical binding]; other site 1205674009685 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1205674009686 active site 1205674009687 DNA Polymerase Y-family; Region: PolY_like; cd03468 1205674009688 DNA binding site [nucleotide binding] 1205674009689 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1205674009690 GMP synthase; Reviewed; Region: guaA; PRK00074 1205674009691 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1205674009692 AMP/PPi binding site [chemical binding]; other site 1205674009693 candidate oxyanion hole; other site 1205674009694 catalytic triad [active] 1205674009695 potential glutamine specificity residues [chemical binding]; other site 1205674009696 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1205674009697 ATP Binding subdomain [chemical binding]; other site 1205674009698 Ligand Binding sites [chemical binding]; other site 1205674009699 Dimerization subdomain; other site 1205674009700 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1205674009701 active site lid residues [active] 1205674009702 substrate binding pocket [chemical binding]; other site 1205674009703 catalytic residues [active] 1205674009704 substrate-Mg2+ binding site; other site 1205674009705 aspartate-rich region 1; other site 1205674009706 aspartate-rich region 2; other site 1205674009707 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205674009708 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205674009709 substrate binding pocket [chemical binding]; other site 1205674009710 chain length determination region; other site 1205674009711 substrate-Mg2+ binding site; other site 1205674009712 catalytic residues [active] 1205674009713 aspartate-rich region 1; other site 1205674009714 active site lid residues [active] 1205674009715 aspartate-rich region 2; other site 1205674009716 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674009717 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674009718 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1205674009719 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205674009720 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1205674009721 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1205674009722 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1205674009723 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1205674009724 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1205674009725 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205674009726 inhibitor-cofactor binding pocket; inhibition site 1205674009727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674009728 catalytic residue [active] 1205674009729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1205674009730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674009731 hypothetical protein; Provisional; Region: PRK07579 1205674009732 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1205674009733 active site 1205674009734 cosubstrate binding site; other site 1205674009735 substrate binding site [chemical binding]; other site 1205674009736 catalytic site [active] 1205674009737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674009738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674009739 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1205674009740 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1205674009741 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205674009742 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1205674009743 putative active site [active] 1205674009744 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1205674009745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674009746 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205674009747 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1205674009748 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205674009749 phosphate binding site [ion binding]; other site 1205674009750 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1205674009751 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205674009752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1205674009753 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205674009754 active site 1205674009755 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1205674009756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674009757 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674009758 DNA binding residues [nucleotide binding] 1205674009759 Transcription factor WhiB; Region: Whib; pfam02467 1205674009760 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205674009761 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205674009762 ring oligomerisation interface [polypeptide binding]; other site 1205674009763 ATP/Mg binding site [chemical binding]; other site 1205674009764 stacking interactions; other site 1205674009765 hinge regions; other site 1205674009766 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1205674009767 oligomerisation interface [polypeptide binding]; other site 1205674009768 mobile loop; other site 1205674009769 roof hairpin; other site 1205674009770 UGMP family protein; Validated; Region: PRK09604 1205674009771 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1205674009772 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1205674009773 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205674009774 Coenzyme A binding pocket [chemical binding]; other site 1205674009775 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1205674009776 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1205674009777 alanine racemase; Reviewed; Region: alr; PRK00053 1205674009778 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1205674009779 active site 1205674009780 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205674009781 dimer interface [polypeptide binding]; other site 1205674009782 substrate binding site [chemical binding]; other site 1205674009783 catalytic residues [active] 1205674009784 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009785 PPE family; Region: PPE; pfam00823 1205674009786 Evidence 4 : Homologs of previously reported genes of unknown function 1205674009787 Evidence 4 : Homologs of previously reported genes of unknown function 1205674009788 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009789 PPE family; Region: PPE; pfam00823 1205674009790 Evidence 4 : Homologs of previously reported genes of unknown function 1205674009791 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009792 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009793 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009794 PPE family; Region: PPE; pfam00823 1205674009795 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674009796 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009797 PPE family; Region: PPE; pfam00823 1205674009798 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205674009799 MULE transposase domain; Region: MULE; pfam10551 1205674009800 PPE family; Region: PPE; pfam00823 1205674009801 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009802 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674009803 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674009804 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009805 PPE family; Region: PPE; pfam00823 1205674009806 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009807 PPE family; Region: PPE; pfam00823 1205674009808 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009809 PPE family; Region: PPE; pfam00823 1205674009810 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009811 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009812 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009813 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674009814 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1205674009815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674009816 catalytic residue [active] 1205674009817 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1205674009818 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1205674009819 putative substrate binding site [chemical binding]; other site 1205674009820 putative ATP binding site [chemical binding]; other site 1205674009821 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1205674009822 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1205674009823 glutaminase active site [active] 1205674009824 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1205674009825 dimer interface [polypeptide binding]; other site 1205674009826 active site 1205674009827 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1205674009828 dimer interface [polypeptide binding]; other site 1205674009829 active site 1205674009830 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1205674009831 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1205674009832 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1205674009833 active site 1205674009834 substrate binding site [chemical binding]; other site 1205674009835 metal binding site [ion binding]; metal-binding site 1205674009836 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1205674009837 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1205674009838 23S rRNA interface [nucleotide binding]; other site 1205674009839 L3 interface [polypeptide binding]; other site 1205674009840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205674009841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205674009842 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1205674009843 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12775759, 15525680 1205674009844 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12775759, 15525680 1205674009845 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205674009846 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205674009847 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205674009848 active site 1205674009849 catalytic residues [active] 1205674009850 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205674009851 Cutinase; Region: Cutinase; pfam01083 1205674009852 Cutinase; Region: Cutinase; pfam01083 1205674009853 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1205674009854 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1205674009855 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1205674009856 dimerization interface 3.5A [polypeptide binding]; other site 1205674009857 active site 1205674009858 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1205674009859 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1205674009860 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1205674009861 alphaNTD - beta interaction site [polypeptide binding]; other site 1205674009862 alphaNTD homodimer interface [polypeptide binding]; other site 1205674009863 alphaNTD - beta' interaction site [polypeptide binding]; other site 1205674009864 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1205674009865 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1205674009866 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1205674009867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205674009868 RNA binding surface [nucleotide binding]; other site 1205674009869 30S ribosomal protein S11; Validated; Region: PRK05309 1205674009870 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1205674009871 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1205674009872 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1205674009873 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1205674009874 rRNA binding site [nucleotide binding]; other site 1205674009875 predicted 30S ribosome binding site; other site 1205674009876 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1205674009877 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1205674009878 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1205674009879 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1205674009880 NAD binding site [chemical binding]; other site 1205674009881 substrate binding site [chemical binding]; other site 1205674009882 homodimer interface [polypeptide binding]; other site 1205674009883 active site 1205674009884 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1205674009885 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674009886 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674009887 active site 1205674009888 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205674009889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674009890 NAD(P) binding site [chemical binding]; other site 1205674009891 active site 1205674009892 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1205674009893 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1205674009894 active site 1205674009895 catalytic residues [active] 1205674009896 metal binding site [ion binding]; metal-binding site 1205674009897 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1205674009898 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205674009899 PYR/PP interface [polypeptide binding]; other site 1205674009900 dimer interface [polypeptide binding]; other site 1205674009901 TPP binding site [chemical binding]; other site 1205674009902 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205674009903 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1205674009904 TPP-binding site [chemical binding]; other site 1205674009905 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1205674009906 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1205674009907 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674009908 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205674009909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674009910 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205674009911 putative substrate translocation pore; other site 1205674009912 PE family; Region: PE; pfam00934 1205674009913 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674009914 PPE family; Region: PPE; pfam00823 1205674009915 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674009916 patatin-related protein; Region: TIGR03607 1205674009917 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674009918 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674009919 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1205674009920 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205674009921 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1205674009922 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205674009923 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205674009924 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205674009925 short chain dehydrogenase; Provisional; Region: PRK05875 1205674009926 classical (c) SDRs; Region: SDR_c; cd05233 1205674009927 NAD(P) binding site [chemical binding]; other site 1205674009928 active site 1205674009929 Predicted membrane protein [Function unknown]; Region: COG2259 1205674009930 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205674009931 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205674009932 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205674009933 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205674009934 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1205674009935 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1205674009936 active site 1205674009937 homotetramer interface [polypeptide binding]; other site 1205674009938 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674009939 mce related protein; Region: MCE; pfam02470 1205674009940 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674009941 mce related protein; Region: MCE; pfam02470 1205674009942 mce related protein; Region: MCE; pfam02470 1205674009943 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674009944 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674009945 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674009946 mce related protein; Region: MCE; pfam02470 1205674009947 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674009948 mce related protein; Region: MCE; pfam02470 1205674009949 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205674009950 mce related protein; Region: MCE; pfam02470 1205674009951 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205674009952 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674009953 Permease; Region: Permease; pfam02405 1205674009954 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205674009955 Permease; Region: Permease; pfam02405 1205674009956 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1205674009957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674009958 NAD(P) binding site [chemical binding]; other site 1205674009959 active site 1205674009960 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205674009961 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205674009962 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674009963 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205674009964 FAD binding site [chemical binding]; other site 1205674009965 substrate binding site [chemical binding]; other site 1205674009966 catalytic base [active] 1205674009967 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674009968 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205674009969 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674009970 active site 1205674009971 acyl-CoA synthetase; Validated; Region: PRK07867 1205674009972 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1205674009973 acyl-activating enzyme (AAE) consensus motif; other site 1205674009974 putative AMP binding site [chemical binding]; other site 1205674009975 putative active site [active] 1205674009976 putative CoA binding site [chemical binding]; other site 1205674009977 PE family; Region: PE; pfam00934 1205674009978 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11973159, 12657046 1205674009979 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11973159, 12657046 1205674009980 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11973159, 12657046 1205674009981 PE family; Region: PE; pfam00934 1205674009982 hypothetical protein; Validated; Region: PRK07586 1205674009983 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205674009984 PYR/PP interface [polypeptide binding]; other site 1205674009985 dimer interface [polypeptide binding]; other site 1205674009986 TPP binding site [chemical binding]; other site 1205674009987 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1205674009988 TPP-binding site [chemical binding]; other site 1205674009989 dimer interface [polypeptide binding]; other site 1205674009990 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205674009991 PE family; Region: PE; pfam00934 1205674009992 Evidence 4 : Homologs of previously reported genes of unknown function 1205674009993 acyl-CoA synthetase; Validated; Region: PRK07798 1205674009994 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674009995 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1205674009996 acyl-activating enzyme (AAE) consensus motif; other site 1205674009997 acyl-activating enzyme (AAE) consensus motif; other site 1205674009998 putative AMP binding site [chemical binding]; other site 1205674009999 putative active site [active] 1205674010000 putative CoA binding site [chemical binding]; other site 1205674010001 enoyl-CoA hydratase; Provisional; Region: PRK07799 1205674010002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674010003 substrate binding site [chemical binding]; other site 1205674010004 oxyanion hole (OAH) forming residues; other site 1205674010005 trimer interface [polypeptide binding]; other site 1205674010006 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674010007 Cytochrome P450; Region: p450; cl12078 1205674010008 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1205674010009 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205674010010 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1205674010011 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205674010012 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205674010013 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205674010014 lipid-transfer protein; Provisional; Region: PRK07937 1205674010015 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205674010016 active site 1205674010017 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1205674010018 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205674010019 active site 1205674010020 NHL repeat; Region: NHL; pfam01436 1205674010021 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205674010022 NHL repeat; Region: NHL; pfam01436 1205674010023 NHL repeat; Region: NHL; pfam01436 1205674010024 NHL repeat; Region: NHL; pfam01436 1205674010025 NHL repeat; Region: NHL; pfam01436 1205674010026 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1205674010027 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1205674010028 trimer interface [polypeptide binding]; other site 1205674010029 putative metal binding site [ion binding]; other site 1205674010030 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1205674010031 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1205674010032 O-methyltransferase; Region: Methyltransf_2; pfam00891 1205674010033 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1205674010034 short chain dehydrogenase; Provisional; Region: PRK07890 1205674010035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674010036 NAD(P) binding site [chemical binding]; other site 1205674010037 active site 1205674010038 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010039 PPE family; Region: PPE; pfam00823 1205674010040 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205674010041 PPE family; Region: PPE; pfam00823 1205674010042 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010043 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205674010044 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1205674010045 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1205674010046 active site 1205674010047 catalytic residues [active] 1205674010048 metal binding site [ion binding]; metal-binding site 1205674010049 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1205674010050 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1205674010051 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205674010052 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1205674010053 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1205674010054 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1205674010055 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205674010056 enoyl-CoA hydratase; Region: PLN02864 1205674010057 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205674010058 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1205674010059 dimer interaction site [polypeptide binding]; other site 1205674010060 substrate-binding tunnel; other site 1205674010061 active site 1205674010062 catalytic site [active] 1205674010063 substrate binding site [chemical binding]; other site 1205674010064 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010065 PPE family; Region: PPE; pfam00823 1205674010066 PE-PPE domain; Region: PE-PPE; pfam08237 1205674010067 lipid-transfer protein; Provisional; Region: PRK07855 1205674010068 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205674010069 active site 1205674010070 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1205674010071 putative active site [active] 1205674010072 putative catalytic site [active] 1205674010073 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205674010074 active site 1205674010075 catalytic site [active] 1205674010076 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205674010077 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205674010078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010079 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010080 active site 1205674010081 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010082 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205674010083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010084 active site 1205674010085 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674010086 Cytochrome P450; Region: p450; cl12078 1205674010087 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1205674010088 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205674010089 dimer interface [polypeptide binding]; other site 1205674010090 active site 1205674010091 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205674010092 short chain dehydrogenase; Provisional; Region: PRK07791 1205674010093 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1205674010094 homodimer interface [polypeptide binding]; other site 1205674010095 NAD binding site [chemical binding]; other site 1205674010096 active site 1205674010097 short chain dehydrogenase; Provisional; Region: PRK07856 1205674010098 classical (c) SDRs; Region: SDR_c; cd05233 1205674010099 NAD(P) binding site [chemical binding]; other site 1205674010100 active site 1205674010101 enoyl-CoA hydratase; Provisional; Region: PRK06495 1205674010102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674010103 substrate binding site [chemical binding]; other site 1205674010104 oxyanion hole (OAH) forming residues; other site 1205674010105 trimer interface [polypeptide binding]; other site 1205674010106 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1205674010107 Coenzyme A transferase; Region: CoA_trans; cl17247 1205674010108 Nitronate monooxygenase; Region: NMO; pfam03060 1205674010109 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205674010110 FMN binding site [chemical binding]; other site 1205674010111 substrate binding site [chemical binding]; other site 1205674010112 putative catalytic residue [active] 1205674010113 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205674010114 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1205674010115 putative di-iron ligands [ion binding]; other site 1205674010116 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1205674010117 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1205674010118 FAD binding pocket [chemical binding]; other site 1205674010119 FAD binding motif [chemical binding]; other site 1205674010120 phosphate binding motif [ion binding]; other site 1205674010121 beta-alpha-beta structure motif; other site 1205674010122 NAD(p) ribose binding residues [chemical binding]; other site 1205674010123 NAD binding pocket [chemical binding]; other site 1205674010124 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1205674010125 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674010126 catalytic loop [active] 1205674010127 iron binding site [ion binding]; other site 1205674010128 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205674010129 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1205674010130 putative active site [active] 1205674010131 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1205674010132 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205674010133 dimer interface [polypeptide binding]; other site 1205674010134 active site 1205674010135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674010136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674010137 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010138 PPE family; Region: PPE; pfam00823 1205674010139 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205674010140 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010141 PPE family; Region: PPE; pfam00823 1205674010142 short chain dehydrogenase; Provisional; Region: PRK07831 1205674010143 classical (c) SDRs; Region: SDR_c; cd05233 1205674010144 NAD(P) binding site [chemical binding]; other site 1205674010145 active site 1205674010146 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010148 active site 1205674010149 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1205674010150 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205674010151 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1205674010152 acyl-activating enzyme (AAE) consensus motif; other site 1205674010153 putative AMP binding site [chemical binding]; other site 1205674010154 putative active site [active] 1205674010155 putative CoA binding site [chemical binding]; other site 1205674010156 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010157 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010158 active site 1205674010159 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205674010160 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010162 active site 1205674010163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010164 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205674010165 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010166 active site 1205674010167 aspartate aminotransferase; Provisional; Region: PRK05764 1205674010168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674010169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674010170 homodimer interface [polypeptide binding]; other site 1205674010171 catalytic residue [active] 1205674010172 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1205674010173 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205674010174 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1205674010175 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1205674010176 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1205674010177 active site 1205674010178 Fe binding site [ion binding]; other site 1205674010179 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1205674010180 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205674010181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010182 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1205674010183 Flavin binding site [chemical binding]; other site 1205674010184 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205674010185 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1205674010186 FAD binding pocket [chemical binding]; other site 1205674010187 FAD binding motif [chemical binding]; other site 1205674010188 phosphate binding motif [ion binding]; other site 1205674010189 beta-alpha-beta structure motif; other site 1205674010190 NAD(p) ribose binding residues [chemical binding]; other site 1205674010191 NAD binding pocket [chemical binding]; other site 1205674010192 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1205674010193 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1205674010194 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205674010195 catalytic loop [active] 1205674010196 iron binding site [ion binding]; other site 1205674010197 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010199 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205674010200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010201 active site 1205674010202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674010203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674010204 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205674010205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205674010206 DNA binding site [nucleotide binding] 1205674010207 domain linker motif; other site 1205674010208 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1205674010209 putative dimerization interface [polypeptide binding]; other site 1205674010210 putative ligand binding site [chemical binding]; other site 1205674010211 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674010212 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205674010213 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205674010214 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205674010215 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1205674010216 transmembrane helices; other site 1205674010217 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1205674010218 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1205674010219 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1205674010220 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205674010221 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1205674010222 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205674010223 active site 1205674010224 HIGH motif; other site 1205674010225 nucleotide binding site [chemical binding]; other site 1205674010226 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205674010227 KMSKS motif; other site 1205674010228 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1205674010229 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1205674010230 homotrimer interaction site [polypeptide binding]; other site 1205674010231 zinc binding site [ion binding]; other site 1205674010232 CDP-binding sites; other site 1205674010233 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1205674010234 substrate binding site; other site 1205674010235 dimer interface; other site 1205674010236 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1205674010237 DNA repair protein RadA; Provisional; Region: PRK11823 1205674010238 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1205674010239 Walker A motif/ATP binding site; other site 1205674010240 ATP binding site [chemical binding]; other site 1205674010241 Walker B motif; other site 1205674010242 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205674010243 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1205674010244 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1205674010245 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1205674010246 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1205674010247 active site clefts [active] 1205674010248 zinc binding site [ion binding]; other site 1205674010249 dimer interface [polypeptide binding]; other site 1205674010250 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205674010251 endonuclease III; Region: ENDO3c; smart00478 1205674010252 minor groove reading motif; other site 1205674010253 helix-hairpin-helix signature motif; other site 1205674010254 substrate binding pocket [chemical binding]; other site 1205674010255 active site 1205674010256 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1205674010257 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674010258 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205674010259 catalytic site [active] 1205674010260 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1205674010261 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1205674010262 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205674010263 Ami_2 domain; Region: Ami_2; smart00644 1205674010264 amidase catalytic site [active] 1205674010265 Zn binding residues [ion binding]; other site 1205674010266 substrate binding site [chemical binding]; other site 1205674010267 PE family; Region: PE; pfam00934 1205674010268 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1205674010269 Clp amino terminal domain; Region: Clp_N; pfam02861 1205674010270 Clp amino terminal domain; Region: Clp_N; pfam02861 1205674010271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674010272 Walker A motif; other site 1205674010273 ATP binding site [chemical binding]; other site 1205674010274 Walker B motif; other site 1205674010275 arginine finger; other site 1205674010276 UvrB/uvrC motif; Region: UVR; pfam02151 1205674010277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674010278 Walker A motif; other site 1205674010279 ATP binding site [chemical binding]; other site 1205674010280 Walker B motif; other site 1205674010281 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205674010282 Lsr2; Region: Lsr2; pfam11774 1205674010283 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1205674010284 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1205674010285 dimer interface [polypeptide binding]; other site 1205674010286 putative anticodon binding site; other site 1205674010287 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205674010288 motif 1; other site 1205674010289 dimer interface [polypeptide binding]; other site 1205674010290 active site 1205674010291 motif 2; other site 1205674010292 motif 3; other site 1205674010293 pantothenate kinase; Reviewed; Region: PRK13318 1205674010294 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1205674010295 tetramerization interface [polypeptide binding]; other site 1205674010296 active site 1205674010297 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1205674010298 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1205674010299 active site 1205674010300 ATP-binding site [chemical binding]; other site 1205674010301 pantoate-binding site; other site 1205674010302 HXXH motif; other site 1205674010303 Rossmann-like domain; Region: Rossmann-like; pfam10727 1205674010304 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1205674010305 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1205674010306 PE family; Region: PE; pfam00934 1205674010307 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1205674010308 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1205674010309 catalytic center binding site [active] 1205674010310 ATP binding site [chemical binding]; other site 1205674010311 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1205674010312 homooctamer interface [polypeptide binding]; other site 1205674010313 active site 1205674010314 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1205674010315 dihydropteroate synthase; Region: DHPS; TIGR01496 1205674010316 substrate binding pocket [chemical binding]; other site 1205674010317 dimer interface [polypeptide binding]; other site 1205674010318 inhibitor binding site; inhibition site 1205674010319 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1205674010320 homodecamer interface [polypeptide binding]; other site 1205674010321 GTP cyclohydrolase I; Provisional; Region: PLN03044 1205674010322 active site 1205674010323 putative catalytic site residues [active] 1205674010324 zinc binding site [ion binding]; other site 1205674010325 GTP-CH-I/GFRP interaction surface; other site 1205674010326 FtsH Extracellular; Region: FtsH_ext; pfam06480 1205674010327 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1205674010328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674010329 Walker A motif; other site 1205674010330 ATP binding site [chemical binding]; other site 1205674010331 Walker B motif; other site 1205674010332 arginine finger; other site 1205674010333 Peptidase family M41; Region: Peptidase_M41; pfam01434 1205674010334 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205674010335 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674010336 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205674010337 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205674010338 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205674010339 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205674010340 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205674010341 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010342 PPE family; Region: PPE; pfam00823 1205674010343 PE family; Region: PE; pfam00934 1205674010344 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1205674010345 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1205674010346 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674010347 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674010348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205674010349 active site 1205674010350 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1205674010351 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1205674010352 Ligand Binding Site [chemical binding]; other site 1205674010353 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1205674010354 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205674010355 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1205674010356 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1205674010357 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1205674010358 dimer interface [polypeptide binding]; other site 1205674010359 substrate binding site [chemical binding]; other site 1205674010360 metal binding sites [ion binding]; metal-binding site 1205674010361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1205674010362 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1205674010363 Ligand binding site; other site 1205674010364 Putative Catalytic site; other site 1205674010365 DXD motif; other site 1205674010366 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1205674010367 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1205674010368 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205674010369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674010370 NAD(P) binding site [chemical binding]; other site 1205674010371 active site 1205674010372 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674010373 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674010374 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1205674010375 Fic/DOC family; Region: Fic; cl00960 1205674010376 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1205674010377 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674010378 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1205674010379 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1205674010380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205674010381 dimerization interface [polypeptide binding]; other site 1205674010382 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205674010383 cyclase homology domain; Region: CHD; cd07302 1205674010384 nucleotidyl binding site; other site 1205674010385 metal binding site [ion binding]; metal-binding site 1205674010386 dimer interface [polypeptide binding]; other site 1205674010387 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1205674010388 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1205674010389 active site 1205674010390 interdomain interaction site; other site 1205674010391 putative metal-binding site [ion binding]; other site 1205674010392 nucleotide binding site [chemical binding]; other site 1205674010393 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1205674010394 domain I; other site 1205674010395 phosphate binding site [ion binding]; other site 1205674010396 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1205674010397 domain II; other site 1205674010398 domain III; other site 1205674010399 nucleotide binding site [chemical binding]; other site 1205674010400 DNA binding groove [nucleotide binding] 1205674010401 catalytic site [active] 1205674010402 domain IV; other site 1205674010403 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205674010404 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205674010405 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205674010406 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205674010407 DNA-binding site [nucleotide binding]; DNA binding site 1205674010408 RNA-binding motif; other site 1205674010409 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1205674010410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205674010411 ATP binding site [chemical binding]; other site 1205674010412 putative Mg++ binding site [ion binding]; other site 1205674010413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205674010414 nucleotide binding region [chemical binding]; other site 1205674010415 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1205674010416 PE family; Region: PE; pfam00934 1205674010417 Evidence 4 : Homologs of previously reported genes of unknown function 1205674010418 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1205674010419 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1205674010420 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1205674010421 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1205674010422 Walker A motif; other site 1205674010423 hexamer interface [polypeptide binding]; other site 1205674010424 ATP binding site [chemical binding]; other site 1205674010425 Walker B motif; other site 1205674010426 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1205674010427 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205674010428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674010429 motif II; other site 1205674010430 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1205674010431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205674010432 Walker A/P-loop; other site 1205674010433 ATP binding site [chemical binding]; other site 1205674010434 Q-loop/lid; other site 1205674010435 ABC transporter signature motif; other site 1205674010436 Walker B; other site 1205674010437 D-loop; other site 1205674010438 H-loop/switch region; other site 1205674010439 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205674010440 Walker A/P-loop; other site 1205674010441 ATP binding site [chemical binding]; other site 1205674010442 Q-loop/lid; other site 1205674010443 ABC transporter signature motif; other site 1205674010444 Walker B; other site 1205674010445 D-loop; other site 1205674010446 H-loop/switch region; other site 1205674010447 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205674010448 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1205674010449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674010450 ABC-ATPase subunit interface; other site 1205674010451 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205674010452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674010453 dimer interface [polypeptide binding]; other site 1205674010454 conserved gate region; other site 1205674010455 ABC-ATPase subunit interface; other site 1205674010456 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1205674010457 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1205674010458 acetyl-CoA synthetase; Provisional; Region: PRK00174 1205674010459 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1205674010460 active site 1205674010461 CoA binding site [chemical binding]; other site 1205674010462 acyl-activating enzyme (AAE) consensus motif; other site 1205674010463 AMP binding site [chemical binding]; other site 1205674010464 acetate binding site [chemical binding]; other site 1205674010465 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1205674010466 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205674010467 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205674010468 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1205674010469 putative active site [active] 1205674010470 putative CoA binding site [chemical binding]; other site 1205674010471 nudix motif; other site 1205674010472 metal binding site [ion binding]; metal-binding site 1205674010473 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1205674010474 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205674010475 catalytic residues [active] 1205674010476 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1205674010477 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205674010478 minor groove reading motif; other site 1205674010479 helix-hairpin-helix signature motif; other site 1205674010480 substrate binding pocket [chemical binding]; other site 1205674010481 active site 1205674010482 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1205674010483 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674010484 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674010485 ligand binding site [chemical binding]; other site 1205674010486 flexible hinge region; other site 1205674010487 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205674010488 putative switch regulator; other site 1205674010489 non-specific DNA interactions [nucleotide binding]; other site 1205674010490 DNA binding site [nucleotide binding] 1205674010491 sequence specific DNA binding site [nucleotide binding]; other site 1205674010492 putative cAMP binding site [chemical binding]; other site 1205674010493 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205674010494 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1205674010495 homotrimer interaction site [polypeptide binding]; other site 1205674010496 putative active site [active] 1205674010497 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1205674010498 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205674010499 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205674010500 P loop; other site 1205674010501 Nucleotide binding site [chemical binding]; other site 1205674010502 DTAP/Switch II; other site 1205674010503 Switch I; other site 1205674010504 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205674010505 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205674010506 DTAP/Switch II; other site 1205674010507 Switch I; other site 1205674010508 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205674010509 Transcription factor WhiB; Region: Whib; pfam02467 1205674010510 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1205674010511 Transglycosylase; Region: Transgly; pfam00912 1205674010512 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205674010513 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205674010514 phosphodiesterase YaeI; Provisional; Region: PRK11340 1205674010515 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1205674010516 putative active site [active] 1205674010517 putative metal binding site [ion binding]; other site 1205674010518 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205674010519 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205674010520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674010521 catalytic residue [active] 1205674010522 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205674010523 Cytochrome P450; Region: p450; cl12078 1205674010524 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205674010525 anti sigma factor interaction site; other site 1205674010526 regulatory phosphorylation site [posttranslational modification]; other site 1205674010527 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1205674010528 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1205674010529 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1205674010530 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205674010531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674010532 Walker A motif; other site 1205674010533 ATP binding site [chemical binding]; other site 1205674010534 Walker B motif; other site 1205674010535 arginine finger; other site 1205674010536 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205674010537 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205674010538 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1205674010539 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1205674010540 glycerol kinase; Provisional; Region: glpK; PRK00047 1205674010541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205674010542 nucleotide binding site [chemical binding]; other site 1205674010543 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205674010544 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205674010545 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205674010546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674010547 S-adenosylmethionine binding site [chemical binding]; other site 1205674010548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205674010549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674010550 catalytic residue [active] 1205674010551 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1205674010552 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1205674010553 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1205674010554 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1205674010555 putative active site [active] 1205674010556 putative dimer interface [polypeptide binding]; other site 1205674010557 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1205674010558 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1205674010559 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205674010560 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205674010561 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1205674010562 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1205674010563 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205674010564 aspartate kinase; Reviewed; Region: PRK06635 1205674010565 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1205674010566 putative nucleotide binding site [chemical binding]; other site 1205674010567 putative catalytic residues [active] 1205674010568 putative Mg ion binding site [ion binding]; other site 1205674010569 putative aspartate binding site [chemical binding]; other site 1205674010570 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1205674010571 putative allosteric regulatory site; other site 1205674010572 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1205674010573 putative allosteric regulatory residue; other site 1205674010574 2-isopropylmalate synthase; Validated; Region: PRK03739 1205674010575 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1205674010576 active site 1205674010577 catalytic residues [active] 1205674010578 metal binding site [ion binding]; metal-binding site 1205674010579 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1205674010580 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1205674010581 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205674010582 active site 1205674010583 catalytic site [active] 1205674010584 substrate binding site [chemical binding]; other site 1205674010585 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1205674010586 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1205674010587 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205674010588 catalytic triad [active] 1205674010589 recombination protein RecR; Reviewed; Region: recR; PRK00076 1205674010590 RecR protein; Region: RecR; pfam02132 1205674010591 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1205674010592 putative active site [active] 1205674010593 putative metal-binding site [ion binding]; other site 1205674010594 tetramer interface [polypeptide binding]; other site 1205674010595 hypothetical protein; Validated; Region: PRK00153 1205674010596 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1205674010597 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1205674010598 active site 1205674010599 metal binding site [ion binding]; metal-binding site 1205674010600 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1205674010601 hydrophobic ligand binding site; other site 1205674010602 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674010603 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674010604 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205674010605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674010606 S-adenosylmethionine binding site [chemical binding]; other site 1205674010607 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1205674010608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674010609 Walker A motif; other site 1205674010610 ATP binding site [chemical binding]; other site 1205674010611 Walker B motif; other site 1205674010612 arginine finger; other site 1205674010613 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1205674010614 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1205674010615 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205674010616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674010617 catalytic residue [active] 1205674010618 Cutinase; Region: Cutinase; pfam01083 1205674010619 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1205674010620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674010621 NAD(P) binding site [chemical binding]; other site 1205674010622 active site 1205674010623 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205674010624 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1205674010625 putative NAD(P) binding site [chemical binding]; other site 1205674010626 catalytic Zn binding site [ion binding]; other site 1205674010627 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1205674010628 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1205674010629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674010630 putative substrate translocation pore; other site 1205674010631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205674010632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205674010633 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205674010634 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205674010635 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205674010636 active site 1205674010637 nucleophile elbow; other site 1205674010638 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1205674010639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205674010640 FeS/SAM binding site; other site 1205674010641 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205674010642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674010643 S-adenosylmethionine binding site [chemical binding]; other site 1205674010644 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1205674010645 nucleotide binding site [chemical binding]; other site 1205674010646 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1205674010647 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1205674010648 active site 1205674010649 DNA binding site [nucleotide binding] 1205674010650 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1205674010651 DNA binding site [nucleotide binding] 1205674010652 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 1205674010653 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1205674010654 nudix motif; other site 1205674010655 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674010656 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674010657 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1205674010658 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205674010659 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205674010660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205674010661 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1205674010662 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1205674010663 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1205674010664 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010665 PPE family; Region: PPE; pfam00823 1205674010666 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205674010667 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205674010668 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674010669 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1205674010670 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205674010671 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205674010672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205674010673 dimerization interface [polypeptide binding]; other site 1205674010674 putative DNA binding site [nucleotide binding]; other site 1205674010675 putative Zn2+ binding site [ion binding]; other site 1205674010676 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1205674010677 PIN domain; Region: PIN_3; pfam13470 1205674010678 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205674010679 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205674010680 active site 1205674010681 Int/Topo IB signature motif; other site 1205674010682 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205674010683 nucleoside/Zn binding site; other site 1205674010684 dimer interface [polypeptide binding]; other site 1205674010685 catalytic motif [active] 1205674010686 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1205674010687 prephenate dehydrogenase; Validated; Region: PRK06545 1205674010688 prephenate dehydrogenase; Validated; Region: PRK08507 1205674010689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1205674010690 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1205674010691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205674010692 dimer interface [polypeptide binding]; other site 1205674010693 conserved gate region; other site 1205674010694 ABC-ATPase subunit interface; other site 1205674010695 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1205674010696 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1205674010697 Walker A/P-loop; other site 1205674010698 ATP binding site [chemical binding]; other site 1205674010699 Q-loop/lid; other site 1205674010700 ABC transporter signature motif; other site 1205674010701 Walker B; other site 1205674010702 D-loop; other site 1205674010703 H-loop/switch region; other site 1205674010704 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1205674010705 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1205674010706 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1205674010707 putative active site [active] 1205674010708 putative substrate binding site [chemical binding]; other site 1205674010709 ATP binding site [chemical binding]; other site 1205674010710 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1205674010711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205674010712 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1205674010713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205674010714 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1205674010715 dimerization interface [polypeptide binding]; other site 1205674010716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205674010717 dimer interface [polypeptide binding]; other site 1205674010718 phosphorylation site [posttranslational modification] 1205674010719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205674010720 ATP binding site [chemical binding]; other site 1205674010721 Mg2+ binding site [ion binding]; other site 1205674010722 G-X-G motif; other site 1205674010723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205674010724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205674010725 active site 1205674010726 phosphorylation site [posttranslational modification] 1205674010727 intermolecular recognition site; other site 1205674010728 dimerization interface [polypeptide binding]; other site 1205674010729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205674010730 DNA binding site [nucleotide binding] 1205674010731 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1205674010732 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674010733 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674010734 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205674010735 Winged helix-turn helix; Region: HTH_29; pfam13551 1205674010736 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1205674010737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205674010738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205674010739 homodimer interface [polypeptide binding]; other site 1205674010740 catalytic residue [active] 1205674010741 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205674010742 TIGR03086 family protein; Region: TIGR03086 1205674010743 enoyl-CoA hydratase; Provisional; Region: PRK06142 1205674010744 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205674010745 substrate binding site [chemical binding]; other site 1205674010746 oxyanion hole (OAH) forming residues; other site 1205674010747 trimer interface [polypeptide binding]; other site 1205674010748 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205674010749 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205674010750 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205674010751 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205674010752 active site 1205674010753 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1205674010754 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1205674010755 NAD(P) binding site [chemical binding]; other site 1205674010756 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205674010757 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1205674010758 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205674010759 catalytic residue [active] 1205674010760 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1205674010761 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1205674010762 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1205674010763 Walker A/P-loop; other site 1205674010764 ATP binding site [chemical binding]; other site 1205674010765 Q-loop/lid; other site 1205674010766 ABC transporter signature motif; other site 1205674010767 Walker B; other site 1205674010768 D-loop; other site 1205674010769 H-loop/switch region; other site 1205674010770 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205674010771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205674010772 active site 1205674010773 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1205674010774 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205674010775 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205674010776 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1205674010777 NAD binding site [chemical binding]; other site 1205674010778 substrate binding site [chemical binding]; other site 1205674010779 active site 1205674010780 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205674010781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205674010782 active site 1205674010783 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205674010784 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205674010785 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205674010786 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205674010787 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1205674010788 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205674010789 Predicted membrane protein [Function unknown]; Region: COG2246 1205674010790 GtrA-like protein; Region: GtrA; pfam04138 1205674010791 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205674010792 FAD binding domain; Region: FAD_binding_4; pfam01565 1205674010793 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205674010794 short chain dehydrogenase; Provisional; Region: PRK07904 1205674010795 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205674010796 NAD(P) binding site [chemical binding]; other site 1205674010797 active site 1205674010798 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1205674010799 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1205674010800 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205674010801 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205674010802 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205674010803 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205674010804 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1205674010805 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205674010806 FAD binding site [chemical binding]; other site 1205674010807 substrate binding site [chemical binding]; other site 1205674010808 catalytic residues [active] 1205674010809 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205674010810 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205674010811 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205674010812 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674010813 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674010814 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205674010815 active site 1205674010816 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205674010817 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674010818 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674010819 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1205674010820 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1205674010821 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674010822 acyl-activating enzyme (AAE) consensus motif; other site 1205674010823 active site 1205674010824 Cutinase; Region: Cutinase; pfam01083 1205674010825 Predicted esterase [General function prediction only]; Region: COG0627 1205674010826 Putative esterase; Region: Esterase; pfam00756 1205674010827 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1205674010828 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1205674010829 active site 1205674010830 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205674010831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1205674010832 active site 1205674010833 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205674010834 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1205674010835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674010836 UDP-galactopyranose mutase; Region: GLF; pfam03275 1205674010837 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1205674010838 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205674010839 amidase catalytic site [active] 1205674010840 Zn binding residues [ion binding]; other site 1205674010841 substrate binding site [chemical binding]; other site 1205674010842 LGFP repeat; Region: LGFP; pfam08310 1205674010843 PE family; Region: PE; pfam00934 1205674010844 Transposase domain (DUF772); Region: DUF772; pfam05598 1205674010845 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205674010846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205674010847 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1205674010848 active site 1205674010849 motif I; other site 1205674010850 motif II; other site 1205674010851 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205674010852 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674010853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205674010854 putative acyl-acceptor binding pocket; other site 1205674010855 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674010856 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205674010857 putative acyl-acceptor binding pocket; other site 1205674010858 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205674010859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205674010860 putative acyl-acceptor binding pocket; other site 1205674010861 Phosphotransferase enzyme family; Region: APH; pfam01636 1205674010862 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1205674010863 active site 1205674010864 ATP binding site [chemical binding]; other site 1205674010865 antibiotic binding site [chemical binding]; other site 1205674010866 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205674010867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205674010868 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1205674010869 iron-sulfur cluster [ion binding]; other site 1205674010870 [2Fe-2S] cluster binding site [ion binding]; other site 1205674010871 Condensation domain; Region: Condensation; pfam00668 1205674010872 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205674010873 PE-PPE domain; Region: PE-PPE; pfam08237 1205674010874 Evidence 7 : Gene remnant; Product type pe : putative enzyme 1205674010875 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674010876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674010877 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674010878 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205674010879 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205674010880 Condensation domain; Region: Condensation; pfam00668 1205674010881 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205674010882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205674010883 active site 1205674010884 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205674010885 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205674010886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205674010887 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205674010888 Enoylreductase; Region: PKS_ER; smart00829 1205674010889 NAD(P) binding site [chemical binding]; other site 1205674010890 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205674010891 KR domain; Region: KR; pfam08659 1205674010892 putative NADP binding site [chemical binding]; other site 1205674010893 active site 1205674010894 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205674010895 acyl-CoA synthetase; Validated; Region: PRK05850 1205674010896 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205674010897 acyl-activating enzyme (AAE) consensus motif; other site 1205674010898 active site 1205674010899 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205674010900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674010901 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205674010902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674010903 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1205674010904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205674010905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205674010906 Cupin domain; Region: Cupin_2; cl17218 1205674010907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205674010908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205674010909 seryl-tRNA synthetase; Provisional; Region: PRK05431 1205674010910 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1205674010911 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1205674010912 dimer interface [polypeptide binding]; other site 1205674010913 active site 1205674010914 motif 1; other site 1205674010915 motif 2; other site 1205674010916 motif 3; other site 1205674010917 Septum formation; Region: Septum_form; pfam13845 1205674010918 Septum formation; Region: Septum_form; pfam13845 1205674010919 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1205674010920 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205674010921 catalytic core [active] 1205674010922 prephenate dehydratase; Provisional; Region: PRK11898 1205674010923 Prephenate dehydratase; Region: PDT; pfam00800 1205674010924 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1205674010925 putative L-Phe binding site [chemical binding]; other site 1205674010926 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205674010927 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205674010928 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1205674010929 Ferritin-like domain; Region: Ferritin; pfam00210 1205674010930 ferroxidase diiron center [ion binding]; other site 1205674010931 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1205674010932 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205674010933 putative active site [active] 1205674010934 catalytic site [active] 1205674010935 putative metal binding site [ion binding]; other site 1205674010936 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1205674010937 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205674010938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205674010939 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205674010940 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674010941 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205674010942 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1205674010943 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1205674010944 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1205674010945 Evidence 4 : Homologs of previously reported genes of unknown function 1205674010946 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1205674010947 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205674010948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205674010949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205674010950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205674010951 hypothetical protein; Provisional; Region: PRK07945 1205674010952 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1205674010953 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1205674010954 active site 1205674010955 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1205674010956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205674010957 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1205674010958 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1205674010959 active site 1205674010960 dimer interface [polypeptide binding]; other site 1205674010961 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1205674010962 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1205674010963 active site 1205674010964 FMN binding site [chemical binding]; other site 1205674010965 substrate binding site [chemical binding]; other site 1205674010966 3Fe-4S cluster binding site [ion binding]; other site 1205674010967 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1205674010968 domain interface; other site 1205674010969 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205674010970 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205674010971 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205674010972 EspG family; Region: ESX-1_EspG; pfam14011 1205674010973 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205674010974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674010975 Walker A motif; other site 1205674010976 ATP binding site [chemical binding]; other site 1205674010977 Walker B motif; other site 1205674010978 arginine finger; other site 1205674010979 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205674010980 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205674010981 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674010982 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205674010983 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674010984 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674010985 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205674010986 PPE family; Region: PPE; pfam00823 1205674010987 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205674010988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205674010989 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205674010990 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205674010991 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1205674010992 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205674010993 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205674010994 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205674010995 active site 1205674010996 catalytic residues [active] 1205674010997 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205674010998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205674010999 Walker A motif; other site 1205674011000 ATP binding site [chemical binding]; other site 1205674011001 Walker B motif; other site 1205674011002 arginine finger; other site 1205674011003 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205674011004 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205674011005 catalytic residues [active] 1205674011006 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205674011007 active site 1205674011008 catalytic residues [active] 1205674011009 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205674011010 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205674011011 EspG family; Region: ESX-1_EspG; pfam14011 1205674011012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205674011013 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205674011014 PPE family; Region: PPE; pfam00823 1205674011015 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205674011016 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674011017 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205674011018 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674011019 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205674011020 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205674011021 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205674011022 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205674011023 catalytic residue [active] 1205674011024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205674011025 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1205674011026 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1205674011027 active site 1205674011028 NTP binding site [chemical binding]; other site 1205674011029 metal binding triad [ion binding]; metal-binding site 1205674011030 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1205674011031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205674011032 Zn2+ binding site [ion binding]; other site 1205674011033 Mg2+ binding site [ion binding]; other site 1205674011034 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1205674011035 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1205674011036 active site 1205674011037 Ap6A binding site [chemical binding]; other site 1205674011038 nudix motif; other site 1205674011039 metal binding site [ion binding]; metal-binding site 1205674011040 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1205674011041 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1205674011042 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1205674011043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205674011044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205674011045 DNA binding residues [nucleotide binding] 1205674011046 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1205674011047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205674011048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205674011049 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205674011050 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205674011051 catalytic residues [active] 1205674011052 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1205674011053 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205674011054 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205674011055 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1205674011056 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1205674011057 active site 1205674011058 metal binding site [ion binding]; metal-binding site 1205674011059 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1205674011060 ParB-like nuclease domain; Region: ParB; smart00470 1205674011061 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205674011062 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674011063 P-loop; other site 1205674011064 Magnesium ion binding site [ion binding]; other site 1205674011065 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205674011066 Magnesium ion binding site [ion binding]; other site 1205674011067 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1205674011068 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1205674011069 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1205674011070 G-X-X-G motif; other site 1205674011071 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1205674011072 RxxxH motif; other site 1205674011073 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1205674011074 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1205674011075 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1205674011076 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399