-- dump date 20140619_151939 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1205677000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1205677000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677000003 Walker A motif; other site 1205677000004 ATP binding site [chemical binding]; other site 1205677000005 Walker B motif; other site 1205677000006 arginine finger; other site 1205677000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1205677000008 DnaA box-binding interface [nucleotide binding]; other site 1205677000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1205677000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1205677000011 putative DNA binding surface [nucleotide binding]; other site 1205677000012 dimer interface [polypeptide binding]; other site 1205677000013 beta-clamp/clamp loader binding surface; other site 1205677000014 beta-clamp/translesion DNA polymerase binding surface; other site 1205677000015 recF protein; Region: recf; TIGR00611 1205677000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1205677000017 Walker A/P-loop; other site 1205677000018 ATP binding site [chemical binding]; other site 1205677000019 Q-loop/lid; other site 1205677000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677000021 ABC transporter signature motif; other site 1205677000022 Walker B; other site 1205677000023 D-loop; other site 1205677000024 H-loop/switch region; other site 1205677000025 hypothetical protein; Provisional; Region: PRK03195 1205677000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1205677000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677000028 Mg2+ binding site [ion binding]; other site 1205677000029 G-X-G motif; other site 1205677000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1205677000031 anchoring element; other site 1205677000032 dimer interface [polypeptide binding]; other site 1205677000033 ATP binding site [chemical binding]; other site 1205677000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1205677000035 active site 1205677000036 putative metal-binding site [ion binding]; other site 1205677000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1205677000038 DNA gyrase subunit A; Validated; Region: PRK05560 1205677000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1205677000040 CAP-like domain; other site 1205677000041 active site 1205677000042 primary dimer interface [polypeptide binding]; other site 1205677000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205677000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205677000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205677000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205677000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205677000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205677000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1205677000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1205677000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205677000052 active site 1205677000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205677000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 1205677000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205677000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205677000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1205677000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1205677000059 glutamine binding [chemical binding]; other site 1205677000060 catalytic triad [active] 1205677000061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677000062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677000063 active site 1205677000064 ATP binding site [chemical binding]; other site 1205677000065 substrate binding site [chemical binding]; other site 1205677000066 activation loop (A-loop); other site 1205677000067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1205677000068 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205677000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205677000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205677000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205677000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677000073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677000074 active site 1205677000075 ATP binding site [chemical binding]; other site 1205677000076 substrate binding site [chemical binding]; other site 1205677000077 activation loop (A-loop); other site 1205677000078 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205677000079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205677000080 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1205677000081 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1205677000082 active site 1205677000083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677000085 phosphopeptide binding site; other site 1205677000086 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1205677000087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677000089 phosphopeptide binding site; other site 1205677000090 Nitronate monooxygenase; Region: NMO; pfam03060 1205677000091 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205677000092 FMN binding site [chemical binding]; other site 1205677000093 substrate binding site [chemical binding]; other site 1205677000094 putative catalytic residue [active] 1205677000095 Transcription factor WhiB; Region: Whib; pfam02467 1205677000096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205677000097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677000098 non-specific DNA binding site [nucleotide binding]; other site 1205677000099 salt bridge; other site 1205677000100 sequence-specific DNA binding site [nucleotide binding]; other site 1205677000101 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205677000102 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205677000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205677000104 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205677000105 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205677000106 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1205677000107 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1205677000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1205677000109 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1205677000110 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1205677000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677000112 catalytic residue [active] 1205677000113 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1205677000114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1205677000115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1205677000116 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677000117 acyl-activating enzyme (AAE) consensus motif; other site 1205677000118 active site 1205677000119 TIGR03084 family protein; Region: TIGR03084 1205677000120 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205677000121 Wyosine base formation; Region: Wyosine_form; pfam08608 1205677000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205677000123 hypothetical protein; Validated; Region: PRK00228 1205677000124 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205677000125 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1205677000126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677000127 active site 1205677000128 HIGH motif; other site 1205677000129 nucleotide binding site [chemical binding]; other site 1205677000130 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1205677000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677000133 active site 1205677000134 KMSKS motif; other site 1205677000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1205677000136 tRNA binding surface [nucleotide binding]; other site 1205677000137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205677000138 MarR family; Region: MarR; pfam01047 1205677000139 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205677000140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677000141 DNA-binding site [nucleotide binding]; DNA binding site 1205677000142 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1205677000143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677000144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677000145 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1205677000146 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1205677000147 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205677000148 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205677000149 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205677000150 Transglycosylase; Region: Transgly; pfam00912 1205677000151 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1205677000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205677000153 Predicted integral membrane protein [Function unknown]; Region: COG5650 1205677000154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1205677000155 conserved cys residue [active] 1205677000156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1205677000157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1205677000158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1205677000159 dimer interface [polypeptide binding]; other site 1205677000160 ssDNA binding site [nucleotide binding]; other site 1205677000161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1205677000162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1205677000163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1205677000164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1205677000165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1205677000166 replicative DNA helicase; Validated; Region: PRK07773 1205677000167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1205677000168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1205677000169 Walker A motif; other site 1205677000170 ATP binding site [chemical binding]; other site 1205677000171 Walker B motif; other site 1205677000172 DNA binding loops [nucleotide binding] 1205677000173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205677000174 protein-splicing catalytic site; other site 1205677000175 thioester formation/cholesterol transfer; other site 1205677000176 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205677000177 protein-splicing catalytic site; other site 1205677000178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205677000179 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1205677000180 ADP-ribose binding site [chemical binding]; other site 1205677000181 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1205677000182 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1205677000183 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677000184 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677000185 Berberine and berberine like; Region: BBE; pfam08031 1205677000186 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1205677000187 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1205677000188 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205677000189 DNA binding residues [nucleotide binding] 1205677000190 hypothetical protein; Provisional; Region: PRK12438 1205677000191 hypothetical protein; Validated; Region: PRK00068 1205677000192 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205677000193 homotetrameric interface [polypeptide binding]; other site 1205677000194 putative active site [active] 1205677000195 metal binding site [ion binding]; metal-binding site 1205677000196 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1205677000197 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1205677000198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000200 short chain dehydrogenase; Provisional; Region: PRK06197 1205677000201 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205677000202 putative NAD(P) binding site [chemical binding]; other site 1205677000203 active site 1205677000204 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1205677000205 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1205677000206 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1205677000207 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1205677000208 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1205677000209 dimer interface [polypeptide binding]; other site 1205677000210 active site 1205677000211 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1205677000212 folate binding site [chemical binding]; other site 1205677000213 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677000214 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205677000215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205677000216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205677000217 Walker A/P-loop; other site 1205677000218 ATP binding site [chemical binding]; other site 1205677000219 Q-loop/lid; other site 1205677000220 ABC transporter signature motif; other site 1205677000221 Walker B; other site 1205677000222 D-loop; other site 1205677000223 H-loop/switch region; other site 1205677000224 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677000225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677000226 ligand binding site [chemical binding]; other site 1205677000227 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205677000228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205677000229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205677000230 active site 1205677000231 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1205677000232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677000234 homodimer interface [polypeptide binding]; other site 1205677000235 catalytic residue [active] 1205677000236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677000237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000239 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1205677000240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677000241 dimerization interface [polypeptide binding]; other site 1205677000242 putative DNA binding site [nucleotide binding]; other site 1205677000243 putative Zn2+ binding site [ion binding]; other site 1205677000244 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1205677000245 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205677000246 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1205677000247 NADH dehydrogenase; Region: NADHdh; cl00469 1205677000248 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1205677000249 hydrogenase 4 subunit F; Validated; Region: PRK06458 1205677000250 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205677000251 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1205677000252 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1205677000253 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1205677000254 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1205677000255 putative hydrophobic ligand binding site [chemical binding]; other site 1205677000256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677000257 S-adenosylmethionine binding site [chemical binding]; other site 1205677000258 Predicted membrane protein [Function unknown]; Region: COG3305 1205677000259 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1205677000260 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1205677000261 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205677000262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205677000263 metal-binding site [ion binding] 1205677000264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677000265 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205677000266 Predicted integral membrane protein [Function unknown]; Region: COG5660 1205677000267 Putative zinc-finger; Region: zf-HC2; pfam13490 1205677000268 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677000269 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677000270 active site 1205677000271 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000272 PPE family; Region: PPE; pfam00823 1205677000273 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1205677000274 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1205677000275 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1205677000276 acyl-CoA synthetase; Validated; Region: PRK05857 1205677000277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000278 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1205677000279 acyl-activating enzyme (AAE) consensus motif; other site 1205677000280 acyl-activating enzyme (AAE) consensus motif; other site 1205677000281 AMP binding site [chemical binding]; other site 1205677000282 active site 1205677000283 CoA binding site [chemical binding]; other site 1205677000284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205677000285 AMP-binding enzyme; Region: AMP-binding; pfam00501 1205677000286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000288 acyl-activating enzyme (AAE) consensus motif; other site 1205677000289 acyl-activating enzyme (AAE) consensus motif; other site 1205677000290 AMP binding site [chemical binding]; other site 1205677000291 active site 1205677000292 CoA binding site [chemical binding]; other site 1205677000293 Condensation domain; Region: Condensation; pfam00668 1205677000294 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205677000295 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205677000296 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205677000297 acyl-activating enzyme (AAE) consensus motif; other site 1205677000298 AMP binding site [chemical binding]; other site 1205677000299 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205677000300 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1205677000301 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1205677000302 putative NAD(P) binding site [chemical binding]; other site 1205677000303 active site 1205677000304 putative substrate binding site [chemical binding]; other site 1205677000305 Predicted membrane protein [Function unknown]; Region: COG3336 1205677000306 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205677000307 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205677000308 metal-binding site [ion binding] 1205677000309 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677000310 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205677000311 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677000312 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677000313 ligand binding site [chemical binding]; other site 1205677000314 flexible hinge region; other site 1205677000315 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1205677000316 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1205677000317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677000318 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1205677000319 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1205677000320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677000321 motif II; other site 1205677000322 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205677000323 PE family; Region: PE; pfam00934 1205677000324 Rhomboid family; Region: Rhomboid; pfam01694 1205677000325 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205677000326 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1205677000327 active site 1205677000328 catalytic triad [active] 1205677000329 oxyanion hole [active] 1205677000330 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205677000331 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1205677000332 NADP-binding site; other site 1205677000333 homotetramer interface [polypeptide binding]; other site 1205677000334 substrate binding site [chemical binding]; other site 1205677000335 homodimer interface [polypeptide binding]; other site 1205677000336 active site 1205677000337 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1205677000338 dimer interface [polypeptide binding]; other site 1205677000339 active site 1205677000340 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1205677000341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677000342 active site 1205677000343 motif I; other site 1205677000344 motif II; other site 1205677000345 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1205677000346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205677000347 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205677000348 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205677000349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205677000350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205677000351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1205677000352 dimerization interface [polypeptide binding]; other site 1205677000353 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1205677000354 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205677000355 PYR/PP interface [polypeptide binding]; other site 1205677000356 dimer interface [polypeptide binding]; other site 1205677000357 TPP binding site [chemical binding]; other site 1205677000358 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205677000359 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1205677000360 TPP-binding site; other site 1205677000361 dimer interface [polypeptide binding]; other site 1205677000362 acyl-CoA synthetase; Validated; Region: PRK05852 1205677000363 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000364 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1205677000365 acyl-activating enzyme (AAE) consensus motif; other site 1205677000366 acyl-activating enzyme (AAE) consensus motif; other site 1205677000367 putative AMP binding site [chemical binding]; other site 1205677000368 putative active site [active] 1205677000369 putative CoA binding site [chemical binding]; other site 1205677000370 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1205677000371 elongation factor G; Reviewed; Region: PRK12740 1205677000372 G1 box; other site 1205677000373 putative GEF interaction site [polypeptide binding]; other site 1205677000374 GTP/Mg2+ binding site [chemical binding]; other site 1205677000375 Switch I region; other site 1205677000376 G2 box; other site 1205677000377 G3 box; other site 1205677000378 Switch II region; other site 1205677000379 G4 box; other site 1205677000380 G5 box; other site 1205677000381 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205677000382 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205677000383 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205677000384 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1205677000385 PE family; Region: PE; pfam00934 1205677000386 serine endoprotease; Provisional; Region: PRK10898 1205677000387 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205677000388 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205677000389 trehalose synthase; Region: treS_nterm; TIGR02456 1205677000390 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1205677000391 active site 1205677000392 catalytic site [active] 1205677000393 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1205677000394 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1205677000395 Predicted membrane protein [Function unknown]; Region: COG3619 1205677000396 Predicted esterase [General function prediction only]; Region: COG0627 1205677000397 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1205677000398 putative active site [active] 1205677000399 putative catalytic site [active] 1205677000400 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677000401 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677000402 active site 1205677000403 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1205677000404 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205677000405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1205677000406 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677000407 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1205677000408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000410 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677000411 Cytochrome P450; Region: p450; cl12078 1205677000412 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1205677000413 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205677000414 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1205677000415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677000416 NAD(P) binding site [chemical binding]; other site 1205677000417 active site 1205677000418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205677000419 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1205677000420 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1205677000421 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205677000422 minor groove reading motif; other site 1205677000423 helix-hairpin-helix signature motif; other site 1205677000424 active site 1205677000425 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1205677000426 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1205677000427 Cl- selectivity filter; other site 1205677000428 Cl- binding residues [ion binding]; other site 1205677000429 pore gating glutamate residue; other site 1205677000430 dimer interface [polypeptide binding]; other site 1205677000431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000433 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677000434 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677000435 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677000436 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677000437 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1205677000438 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1205677000439 NAD(P) binding site [chemical binding]; other site 1205677000440 catalytic residues [active] 1205677000441 short chain dehydrogenase; Provisional; Region: PRK07791 1205677000442 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1205677000443 NAD binding site [chemical binding]; other site 1205677000444 homodimer interface [polypeptide binding]; other site 1205677000445 active site 1205677000446 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205677000447 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1205677000448 NAD(P) binding site [chemical binding]; other site 1205677000449 PE family; Region: PE; pfam00934 1205677000450 PE-PPE domain; Region: PE-PPE; pfam08237 1205677000451 PE family; Region: PE; pfam00934 1205677000452 PE-PPE domain; Region: PE-PPE; pfam08237 1205677000453 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1205677000454 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1205677000455 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1205677000456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677000457 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1205677000458 FAD binding site [chemical binding]; other site 1205677000459 substrate binding site [chemical binding]; other site 1205677000460 catalytic base [active] 1205677000461 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10510226; Product type pe : putative enzyme 1205677000462 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205677000463 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1205677000464 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1205677000465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000467 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1205677000468 PE family; Region: PE; pfam00934 1205677000469 PE-PPE domain; Region: PE-PPE; pfam08237 1205677000470 PE family; Region: PE; pfam00934 1205677000471 PE-PPE domain; Region: PE-PPE; pfam08237 1205677000472 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677000473 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677000474 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1205677000475 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205677000476 NAD(P) binding site [chemical binding]; other site 1205677000477 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205677000478 active site 1205677000479 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205677000480 putative hydrophobic ligand binding site [chemical binding]; other site 1205677000481 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205677000482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677000483 DNA-binding site [nucleotide binding]; DNA binding site 1205677000484 FCD domain; Region: FCD; pfam07729 1205677000485 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1205677000486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000487 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205677000488 acyl-activating enzyme (AAE) consensus motif; other site 1205677000489 acyl-activating enzyme (AAE) consensus motif; other site 1205677000490 putative AMP binding site [chemical binding]; other site 1205677000491 putative active site [active] 1205677000492 putative CoA binding site [chemical binding]; other site 1205677000493 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677000494 Permease; Region: Permease; pfam02405 1205677000495 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677000496 Permease; Region: Permease; pfam02405 1205677000497 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677000498 mce related protein; Region: MCE; pfam02470 1205677000499 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677000500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677000501 mce related protein; Region: MCE; pfam02470 1205677000502 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677000503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677000504 mce related protein; Region: MCE; pfam02470 1205677000505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677000506 mce related protein; Region: MCE; pfam02470 1205677000507 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677000508 mce related protein; Region: MCE; pfam02470 1205677000509 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677000510 mce related protein; Region: MCE; pfam02470 1205677000511 RDD family; Region: RDD; pfam06271 1205677000512 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1205677000513 Predicted membrane protein [Function unknown]; Region: COG1511 1205677000514 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1205677000515 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1205677000516 Pirin-related protein [General function prediction only]; Region: COG1741 1205677000517 Pirin; Region: Pirin; pfam02678 1205677000518 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1205677000519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677000520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677000521 DNA binding residues [nucleotide binding] 1205677000522 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205677000523 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1205677000524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205677000525 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1205677000526 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1205677000527 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1205677000528 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205677000529 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1205677000530 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1205677000531 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205677000532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677000533 S-adenosylmethionine binding site [chemical binding]; other site 1205677000534 SPW repeat; Region: SPW; pfam03779 1205677000535 SPW repeat; Region: SPW; pfam03779 1205677000536 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1205677000537 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1205677000538 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205677000539 putative homodimer interface [polypeptide binding]; other site 1205677000540 putative homotetramer interface [polypeptide binding]; other site 1205677000541 putative allosteric switch controlling residues; other site 1205677000542 putative metal binding site [ion binding]; other site 1205677000543 putative homodimer-homodimer interface [polypeptide binding]; other site 1205677000544 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205677000545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677000546 putative substrate translocation pore; other site 1205677000547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205677000548 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205677000549 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205677000550 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205677000551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205677000552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677000553 Walker A/P-loop; other site 1205677000554 ATP binding site [chemical binding]; other site 1205677000555 Q-loop/lid; other site 1205677000556 ABC transporter signature motif; other site 1205677000557 Walker B; other site 1205677000558 D-loop; other site 1205677000559 H-loop/switch region; other site 1205677000560 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205677000561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677000562 Walker A/P-loop; other site 1205677000563 ATP binding site [chemical binding]; other site 1205677000564 Q-loop/lid; other site 1205677000565 ABC transporter signature motif; other site 1205677000566 Walker B; other site 1205677000567 D-loop; other site 1205677000568 H-loop/switch region; other site 1205677000569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677000570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677000571 DNA binding residues [nucleotide binding] 1205677000572 dimerization interface [polypeptide binding]; other site 1205677000573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000574 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1205677000575 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1205677000576 putative [Fe4-S4] binding site [ion binding]; other site 1205677000577 putative molybdopterin cofactor binding site [chemical binding]; other site 1205677000578 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677000579 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1205677000580 putative molybdopterin cofactor binding site; other site 1205677000581 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1205677000582 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1205677000583 active site 1205677000584 Zn binding site [ion binding]; other site 1205677000585 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677000586 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1205677000587 Predicted integral membrane protein [Function unknown]; Region: COG0392 1205677000588 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205677000589 MMPL family; Region: MMPL; pfam03176 1205677000590 MMPL family; Region: MMPL; pfam03176 1205677000591 LabA_like proteins; Region: LabA_like; cd06167 1205677000592 putative metal binding site [ion binding]; other site 1205677000593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677000594 S-adenosylmethionine binding site [chemical binding]; other site 1205677000595 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1205677000596 active site 1205677000597 substrate-binding site [chemical binding]; other site 1205677000598 metal-binding site [ion binding] 1205677000599 GTP binding site [chemical binding]; other site 1205677000600 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1205677000601 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677000602 active site 1205677000603 nucleotide binding site [chemical binding]; other site 1205677000604 HIGH motif; other site 1205677000605 KMSKS motif; other site 1205677000606 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1205677000607 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1205677000608 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1205677000609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677000610 FeS/SAM binding site; other site 1205677000611 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1205677000612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000613 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205677000614 acyl-activating enzyme (AAE) consensus motif; other site 1205677000615 acyl-activating enzyme (AAE) consensus motif; other site 1205677000616 putative AMP binding site [chemical binding]; other site 1205677000617 putative active site [active] 1205677000618 putative CoA binding site [chemical binding]; other site 1205677000619 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677000620 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677000621 active site 1205677000622 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1205677000623 putative active site [active] 1205677000624 putative catalytic site [active] 1205677000625 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205677000626 active site 2 [active] 1205677000627 active site 1 [active] 1205677000628 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677000629 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677000630 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1205677000631 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1205677000632 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1205677000633 Moco binding site; other site 1205677000634 metal coordination site [ion binding]; other site 1205677000635 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677000636 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677000637 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677000638 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677000639 enoyl-CoA hydratase; Provisional; Region: PRK08252 1205677000640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677000641 substrate binding site [chemical binding]; other site 1205677000642 oxyanion hole (OAH) forming residues; other site 1205677000643 trimer interface [polypeptide binding]; other site 1205677000644 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1205677000645 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205677000646 NAD binding site [chemical binding]; other site 1205677000647 catalytic residues [active] 1205677000648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677000649 S-adenosylmethionine binding site [chemical binding]; other site 1205677000650 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205677000651 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205677000652 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1205677000653 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205677000654 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677000655 putative active site [active] 1205677000656 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205677000657 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1205677000658 active site 1205677000659 substrate binding pocket [chemical binding]; other site 1205677000660 homodimer interaction site [polypeptide binding]; other site 1205677000661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677000662 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205677000663 active site 1205677000664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000666 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1205677000667 active site 1205677000668 diiron metal binding site [ion binding]; other site 1205677000669 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1205677000670 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1205677000671 NAD(P) binding site [chemical binding]; other site 1205677000672 catalytic residues [active] 1205677000673 Lipase maturation factor; Region: LMF1; pfam06762 1205677000674 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1205677000675 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1205677000676 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205677000677 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1205677000678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000680 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205677000681 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205677000682 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205677000683 active site 2 [active] 1205677000684 active site 1 [active] 1205677000685 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1205677000686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677000687 NAD(P) binding site [chemical binding]; other site 1205677000688 active site 1205677000689 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1205677000690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205677000691 dimer interface [polypeptide binding]; other site 1205677000692 active site 1205677000693 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1205677000694 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1205677000695 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1205677000696 FAD binding site [chemical binding]; other site 1205677000697 substrate binding site [chemical binding]; other site 1205677000698 catalytic residues [active] 1205677000699 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1205677000700 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205677000701 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1205677000702 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677000703 catalytic loop [active] 1205677000704 iron binding site [ion binding]; other site 1205677000705 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1205677000706 L-aspartate oxidase; Provisional; Region: PRK06175 1205677000707 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205677000708 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1205677000709 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1205677000710 putative dimer interface [polypeptide binding]; other site 1205677000711 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1205677000712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677000713 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1205677000714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205677000715 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1205677000716 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1205677000717 homotrimer interface [polypeptide binding]; other site 1205677000718 Walker A motif; other site 1205677000719 GTP binding site [chemical binding]; other site 1205677000720 Walker B motif; other site 1205677000721 cobyric acid synthase; Provisional; Region: PRK00784 1205677000722 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1205677000723 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205677000724 catalytic triad [active] 1205677000725 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000726 PPE family; Region: PPE; pfam00823 1205677000727 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205677000728 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1205677000729 putative active site [active] 1205677000730 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1205677000731 putative active site [active] 1205677000732 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1205677000733 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1205677000734 active site 1205677000735 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1205677000736 DNA binding site [nucleotide binding] 1205677000737 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205677000738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677000739 Coenzyme A binding pocket [chemical binding]; other site 1205677000740 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1205677000741 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1205677000742 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1205677000743 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205677000744 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205677000745 intersubunit interface [polypeptide binding]; other site 1205677000746 5-oxoprolinase; Region: PLN02666 1205677000747 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1205677000748 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1205677000749 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1205677000750 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205677000751 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1205677000752 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205677000753 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1205677000754 nucleotide binding site [chemical binding]; other site 1205677000755 acyl-CoA synthetase; Validated; Region: PRK07788 1205677000756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677000758 active site 1205677000759 CoA binding site [chemical binding]; other site 1205677000760 AMP binding site [chemical binding]; other site 1205677000761 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677000762 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677000763 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205677000764 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677000765 FAD binding site [chemical binding]; other site 1205677000766 substrate binding site [chemical binding]; other site 1205677000767 catalytic base [active] 1205677000768 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205677000769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000771 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1205677000772 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677000773 Zn binding site [ion binding]; other site 1205677000774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205677000775 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205677000776 putative active site [active] 1205677000777 PE family; Region: PE; pfam00934 1205677000778 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000779 PPE family; Region: PPE; pfam00823 1205677000780 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677000781 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677000782 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205677000783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677000784 Walker A motif; other site 1205677000785 ATP binding site [chemical binding]; other site 1205677000786 Walker B motif; other site 1205677000787 arginine finger; other site 1205677000788 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205677000789 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205677000790 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677000791 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205677000792 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677000793 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677000794 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000795 PPE family; Region: PPE; pfam00823 1205677000796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677000797 EspG family; Region: ESX-1_EspG; pfam14011 1205677000798 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205677000799 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205677000800 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205677000801 active site 1205677000802 catalytic residues [active] 1205677000803 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205677000804 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205677000805 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1205677000806 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1205677000807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677000808 S-adenosylmethionine binding site [chemical binding]; other site 1205677000809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1205677000810 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205677000811 Sulfatase; Region: Sulfatase; cl17466 1205677000812 hypothetical protein; Region: PHA01748 1205677000813 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205677000814 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000815 PPE family; Region: PPE; pfam00823 1205677000816 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000817 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000818 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000819 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000820 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000821 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000822 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000823 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000824 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000825 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000826 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1205677000827 putative FMN binding site [chemical binding]; other site 1205677000828 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1205677000829 active site 1205677000830 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1205677000831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1205677000832 SnoaL-like domain; Region: SnoaL_4; pfam13577 1205677000833 SnoaL-like domain; Region: SnoaL_3; pfam13474 1205677000834 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1205677000835 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205677000836 nucleotide binding site [chemical binding]; other site 1205677000837 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1205677000838 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205677000839 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1205677000840 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1205677000841 active site 1205677000842 catalytic residues [active] 1205677000843 Muconolactone delta-isomerase; Region: MIase; cl01992 1205677000844 Muconolactone delta-isomerase; Region: MIase; cl01992 1205677000845 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1205677000846 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205677000847 putative active site [active] 1205677000848 catalytic site [active] 1205677000849 putative metal binding site [ion binding]; other site 1205677000850 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1205677000851 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759; Product type pe : putative enzyme 1205677000852 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205677000853 trimer interface [polypeptide binding]; other site 1205677000854 active site 1205677000855 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1205677000856 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205677000857 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1205677000858 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1205677000859 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1205677000860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677000861 dimerization interface [polypeptide binding]; other site 1205677000862 putative DNA binding site [nucleotide binding]; other site 1205677000863 putative Zn2+ binding site [ion binding]; other site 1205677000864 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205677000865 active site residue [active] 1205677000866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677000867 S-adenosylmethionine binding site [chemical binding]; other site 1205677000868 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677000869 Cytochrome P450; Region: p450; cl12078 1205677000870 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1205677000871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000872 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1205677000873 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1205677000874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205677000877 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205677000878 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205677000879 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1205677000880 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1205677000881 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1205677000882 substrate binding site; other site 1205677000883 tetramer interface; other site 1205677000884 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677000885 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677000886 active site 1205677000887 aminotransferase AlaT; Validated; Region: PRK09265 1205677000888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677000889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677000890 homodimer interface [polypeptide binding]; other site 1205677000891 catalytic residue [active] 1205677000892 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1205677000893 4Fe-4S binding domain; Region: Fer4; pfam00037 1205677000894 Cysteine-rich domain; Region: CCG; pfam02754 1205677000895 Cysteine-rich domain; Region: CCG; pfam02754 1205677000896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677000897 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677000898 DNA binding residues [nucleotide binding] 1205677000899 dimerization interface [polypeptide binding]; other site 1205677000900 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1205677000901 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205677000902 G1 box; other site 1205677000903 GTP/Mg2+ binding site [chemical binding]; other site 1205677000904 G2 box; other site 1205677000905 Switch I region; other site 1205677000906 G3 box; other site 1205677000907 Switch II region; other site 1205677000908 G4 box; other site 1205677000909 G5 box; other site 1205677000910 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1205677000911 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205677000912 G1 box; other site 1205677000913 GTP/Mg2+ binding site [chemical binding]; other site 1205677000914 G2 box; other site 1205677000915 Switch I region; other site 1205677000916 G3 box; other site 1205677000917 Switch II region; other site 1205677000918 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205677000919 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205677000920 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205677000921 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1205677000922 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1205677000923 nucleotide binding site [chemical binding]; other site 1205677000924 NEF interaction site [polypeptide binding]; other site 1205677000925 SBD interface [polypeptide binding]; other site 1205677000926 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1205677000927 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1205677000928 dimer interface [polypeptide binding]; other site 1205677000929 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1205677000930 chaperone protein DnaJ; Provisional; Region: PRK14279 1205677000931 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205677000932 HSP70 interaction site [polypeptide binding]; other site 1205677000933 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205677000934 Zn binding sites [ion binding]; other site 1205677000935 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205677000936 dimer interface [polypeptide binding]; other site 1205677000937 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1205677000938 DNA binding residues [nucleotide binding] 1205677000939 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205677000940 putative dimer interface [polypeptide binding]; other site 1205677000941 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000942 PPE family; Region: PPE; pfam00823 1205677000943 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000944 PPE family; Region: PPE; pfam00823 1205677000945 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000946 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000947 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000948 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000949 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000950 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677000952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677000953 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000954 PPE family; Region: PPE; pfam00823 1205677000955 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000956 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000957 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000958 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000959 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677000961 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000962 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677000963 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205677000964 CoenzymeA binding site [chemical binding]; other site 1205677000965 subunit interaction site [polypeptide binding]; other site 1205677000966 PHB binding site; other site 1205677000967 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1205677000968 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1205677000969 GDP-binding site [chemical binding]; other site 1205677000970 ACT binding site; other site 1205677000971 IMP binding site; other site 1205677000972 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1205677000973 Peptidase family M50; Region: Peptidase_M50; pfam02163 1205677000974 active site 1205677000975 putative substrate binding region [chemical binding]; other site 1205677000976 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1205677000977 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1205677000978 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1205677000979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1205677000980 Divalent cation transporter; Region: MgtE; pfam01769 1205677000981 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1205677000982 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1205677000983 active site 1205677000984 intersubunit interface [polypeptide binding]; other site 1205677000985 zinc binding site [ion binding]; other site 1205677000986 Na+ binding site [ion binding]; other site 1205677000987 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1205677000988 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1205677000989 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1205677000990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1205677000991 AAA domain; Region: AAA_33; pfam13671 1205677000992 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1205677000993 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1205677000994 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1205677000995 metal ion-dependent adhesion site (MIDAS); other site 1205677000996 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1205677000997 putative hydrophobic ligand binding site [chemical binding]; other site 1205677000998 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205677000999 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1205677001000 Ligand binding site; other site 1205677001001 metal-binding site 1205677001002 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1205677001003 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205677001004 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205677001005 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1205677001006 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1205677001007 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1205677001008 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1205677001009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677001010 catalytic loop [active] 1205677001011 iron binding site [ion binding]; other site 1205677001012 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1205677001013 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1205677001014 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1205677001015 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1205677001016 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205677001017 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205677001018 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205677001019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205677001020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205677001021 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1205677001022 dimerization interface [polypeptide binding]; other site 1205677001023 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1205677001024 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205677001025 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205677001026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677001027 active site 1205677001028 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 1205677001029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677001030 salt bridge; other site 1205677001031 non-specific DNA binding site [nucleotide binding]; other site 1205677001032 sequence-specific DNA binding site [nucleotide binding]; other site 1205677001033 Restriction endonuclease; Region: Mrr_cat; pfam04471 1205677001034 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1205677001035 Clp amino terminal domain; Region: Clp_N; pfam02861 1205677001036 Clp amino terminal domain; Region: Clp_N; pfam02861 1205677001037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677001038 Walker A motif; other site 1205677001039 ATP binding site [chemical binding]; other site 1205677001040 Walker B motif; other site 1205677001041 arginine finger; other site 1205677001042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677001043 Walker A motif; other site 1205677001044 ATP binding site [chemical binding]; other site 1205677001045 Walker B motif; other site 1205677001046 arginine finger; other site 1205677001047 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205677001048 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1205677001049 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1205677001050 heme-binding site [chemical binding]; other site 1205677001051 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1205677001052 FAD binding pocket [chemical binding]; other site 1205677001053 FAD binding motif [chemical binding]; other site 1205677001054 phosphate binding motif [ion binding]; other site 1205677001055 beta-alpha-beta structure motif; other site 1205677001056 NAD binding pocket [chemical binding]; other site 1205677001057 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677001058 cyclase homology domain; Region: CHD; cd07302 1205677001059 nucleotidyl binding site; other site 1205677001060 metal binding site [ion binding]; metal-binding site 1205677001061 dimer interface [polypeptide binding]; other site 1205677001062 Predicted ATPase [General function prediction only]; Region: COG3903 1205677001063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205677001064 Walker A motif; other site 1205677001065 ATP binding site [chemical binding]; other site 1205677001066 Walker B motif; other site 1205677001067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677001068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677001069 DNA binding residues [nucleotide binding] 1205677001070 dimerization interface [polypeptide binding]; other site 1205677001071 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677001072 PPE family; Region: PPE; pfam00823 1205677001073 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1205677001074 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205677001075 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1205677001076 active site residue [active] 1205677001077 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1205677001078 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205677001079 homodimer interface [polypeptide binding]; other site 1205677001080 substrate-cofactor binding pocket; other site 1205677001081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677001082 catalytic residue [active] 1205677001083 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205677001084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677001085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677001086 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1205677001087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677001088 FAD binding site [chemical binding]; other site 1205677001089 substrate binding pocket [chemical binding]; other site 1205677001090 catalytic base [active] 1205677001091 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1205677001092 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677001093 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205677001094 acyl-CoA synthetase; Validated; Region: PRK05850 1205677001095 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677001096 acyl-activating enzyme (AAE) consensus motif; other site 1205677001097 active site 1205677001098 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1205677001099 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677001100 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205677001101 active site 1205677001102 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205677001103 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677001104 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677001105 Thioesterase; Region: PKS_TE; smart00824 1205677001106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205677001107 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1205677001108 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1205677001109 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205677001110 phosphate acetyltransferase; Reviewed; Region: PRK05632 1205677001111 DRTGG domain; Region: DRTGG; pfam07085 1205677001112 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1205677001113 propionate/acetate kinase; Provisional; Region: PRK12379 1205677001114 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1205677001115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677001116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677001117 active site 1205677001118 ATP binding site [chemical binding]; other site 1205677001119 substrate binding site [chemical binding]; other site 1205677001120 activation loop (A-loop); other site 1205677001121 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1205677001122 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205677001123 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1205677001124 substrate binding pocket [chemical binding]; other site 1205677001125 membrane-bound complex binding site; other site 1205677001126 hinge residues; other site 1205677001127 NUDIX domain; Region: NUDIX; pfam00293 1205677001128 nudix motif; other site 1205677001129 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1205677001130 thiamine phosphate binding site [chemical binding]; other site 1205677001131 active site 1205677001132 pyrophosphate binding site [ion binding]; other site 1205677001133 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1205677001134 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1205677001135 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1205677001136 thiS-thiF/thiG interaction site; other site 1205677001137 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1205677001138 ThiS interaction site; other site 1205677001139 putative active site [active] 1205677001140 tetramer interface [polypeptide binding]; other site 1205677001141 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1205677001142 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205677001143 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1205677001144 PA/protease or protease-like domain interface [polypeptide binding]; other site 1205677001145 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1205677001146 active site 1205677001147 metal binding site [ion binding]; metal-binding site 1205677001148 Predicted metalloprotease [General function prediction only]; Region: COG2321 1205677001149 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1205677001150 Zn binding site [ion binding]; other site 1205677001151 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205677001152 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1205677001153 dimer interface [polypeptide binding]; other site 1205677001154 substrate binding site [chemical binding]; other site 1205677001155 ATP binding site [chemical binding]; other site 1205677001156 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1205677001157 ThiC-associated domain; Region: ThiC-associated; pfam13667 1205677001158 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1205677001159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677001160 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1205677001161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677001162 motif II; other site 1205677001163 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205677001164 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1205677001165 putative catalytic site [active] 1205677001166 putative phosphate binding site [ion binding]; other site 1205677001167 active site 1205677001168 metal binding site A [ion binding]; metal-binding site 1205677001169 DNA binding site [nucleotide binding] 1205677001170 putative AP binding site [nucleotide binding]; other site 1205677001171 putative metal binding site B [ion binding]; other site 1205677001172 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1205677001173 active site 1205677001174 catalytic residues [active] 1205677001175 metal binding site [ion binding]; metal-binding site 1205677001176 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1205677001177 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205677001178 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1205677001179 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1205677001180 E-class dimer interface [polypeptide binding]; other site 1205677001181 P-class dimer interface [polypeptide binding]; other site 1205677001182 active site 1205677001183 Cu2+ binding site [ion binding]; other site 1205677001184 Zn2+ binding site [ion binding]; other site 1205677001185 carboxylate-amine ligase; Provisional; Region: PRK13517 1205677001186 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1205677001187 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1205677001188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677001189 non-specific DNA binding site [nucleotide binding]; other site 1205677001190 salt bridge; other site 1205677001191 sequence-specific DNA binding site [nucleotide binding]; other site 1205677001192 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1205677001193 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1205677001194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677001195 Walker A motif; other site 1205677001196 ATP binding site [chemical binding]; other site 1205677001197 Walker B motif; other site 1205677001198 arginine finger; other site 1205677001199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677001200 Walker A motif; other site 1205677001201 ATP binding site [chemical binding]; other site 1205677001202 Walker B motif; other site 1205677001203 arginine finger; other site 1205677001204 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1205677001205 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1205677001206 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1205677001207 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205677001208 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205677001209 dimer interface [polypeptide binding]; other site 1205677001210 putative functional site; other site 1205677001211 putative MPT binding site; other site 1205677001212 short chain dehydrogenase; Provisional; Region: PRK06197 1205677001213 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205677001214 putative NAD(P) binding site [chemical binding]; other site 1205677001215 active site 1205677001216 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205677001217 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205677001218 ring oligomerisation interface [polypeptide binding]; other site 1205677001219 ATP/Mg binding site [chemical binding]; other site 1205677001220 stacking interactions; other site 1205677001221 hinge regions; other site 1205677001222 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1205677001223 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677001224 PPE family; Region: PPE; pfam00823 1205677001225 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1205677001226 DinB superfamily; Region: DinB_2; pfam12867 1205677001227 putative anti-sigmaE protein; Provisional; Region: PRK13920 1205677001228 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1205677001229 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1205677001230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677001231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677001232 DNA binding residues [nucleotide binding] 1205677001233 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1205677001234 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001236 S-adenosylmethionine binding site [chemical binding]; other site 1205677001237 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 1205677001238 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1205677001239 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1205677001240 dimer interface [polypeptide binding]; other site 1205677001241 Transport protein; Region: actII; TIGR00833 1205677001242 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205677001243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677001244 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677001245 PPE family; Region: PPE; pfam00823 1205677001246 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677001247 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1205677001248 enoyl-CoA hydratase; Provisional; Region: PRK12478 1205677001249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677001250 substrate binding site [chemical binding]; other site 1205677001251 oxyanion hole (OAH) forming residues; other site 1205677001252 trimer interface [polypeptide binding]; other site 1205677001253 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1205677001254 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677001255 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205677001256 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205677001257 NAD(P) binding site [chemical binding]; other site 1205677001258 catalytic residues [active] 1205677001259 Protein of unknown function (DUF779); Region: DUF779; cl01432 1205677001260 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1205677001261 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1205677001262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677001263 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205677001264 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205677001265 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205677001266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205677001267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677001268 non-specific DNA binding site [nucleotide binding]; other site 1205677001269 salt bridge; other site 1205677001270 sequence-specific DNA binding site [nucleotide binding]; other site 1205677001271 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1205677001272 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205677001273 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1205677001274 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1205677001275 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205677001276 active site 1205677001277 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205677001278 active site 2 [active] 1205677001279 isocitrate lyase; Provisional; Region: PRK15063 1205677001280 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1205677001281 oligomerization interface [polypeptide binding]; other site 1205677001282 active site 1205677001283 metal binding site [ion binding]; metal-binding site 1205677001284 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1205677001285 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205677001286 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205677001287 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001289 S-adenosylmethionine binding site [chemical binding]; other site 1205677001290 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677001292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001293 S-adenosylmethionine binding site [chemical binding]; other site 1205677001294 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1205677001295 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205677001296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677001297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677001298 Predicted membrane protein [Function unknown]; Region: COG2733 1205677001299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205677001300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677001301 non-specific DNA binding site [nucleotide binding]; other site 1205677001302 salt bridge; other site 1205677001303 sequence-specific DNA binding site [nucleotide binding]; other site 1205677001304 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1205677001305 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1205677001306 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1205677001307 intersubunit interface [polypeptide binding]; other site 1205677001308 active site 1205677001309 catalytic residue [active] 1205677001310 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205677001311 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1205677001312 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1205677001313 putative active site [active] 1205677001314 catalytic triad [active] 1205677001315 putative dimer interface [polypeptide binding]; other site 1205677001316 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1205677001317 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1205677001318 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677001319 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1205677001320 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205677001321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205677001322 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205677001323 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205677001324 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1205677001325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677001326 NAD(P) binding site [chemical binding]; other site 1205677001327 active site 1205677001328 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205677001329 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205677001330 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1205677001331 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1205677001332 putative ADP-binding pocket [chemical binding]; other site 1205677001333 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1205677001334 L-lysine exporter; Region: 2a75; TIGR00948 1205677001335 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677001336 catalytic core [active] 1205677001337 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1205677001338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677001339 dimer interface [polypeptide binding]; other site 1205677001340 phosphorylation site [posttranslational modification] 1205677001341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677001342 ATP binding site [chemical binding]; other site 1205677001343 Mg2+ binding site [ion binding]; other site 1205677001344 G-X-G motif; other site 1205677001345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677001346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677001347 active site 1205677001348 phosphorylation site [posttranslational modification] 1205677001349 intermolecular recognition site; other site 1205677001350 dimerization interface [polypeptide binding]; other site 1205677001351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677001352 DNA binding site [nucleotide binding] 1205677001353 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1205677001354 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205677001355 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205677001356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677001357 DNA-binding site [nucleotide binding]; DNA binding site 1205677001358 FCD domain; Region: FCD; pfam07729 1205677001359 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1205677001360 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1205677001361 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1205677001362 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1205677001363 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1205677001364 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1205677001365 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1205677001366 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1205677001367 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1205677001368 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205677001369 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205677001370 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1205677001371 putative NAD(P) binding site [chemical binding]; other site 1205677001372 active site 1205677001373 putative substrate binding site [chemical binding]; other site 1205677001374 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677001375 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205677001376 putative acyl-acceptor binding pocket; other site 1205677001377 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677001379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001380 S-adenosylmethionine binding site [chemical binding]; other site 1205677001381 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205677001382 active site 1205677001383 catalytic site [active] 1205677001384 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205677001385 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1205677001386 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205677001387 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677001388 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1205677001389 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1205677001390 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1205677001391 tRNA; other site 1205677001392 putative tRNA binding site [nucleotide binding]; other site 1205677001393 putative NADP binding site [chemical binding]; other site 1205677001394 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1205677001395 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1205677001396 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1205677001397 domain interfaces; other site 1205677001398 active site 1205677001399 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1205677001400 active site 1205677001401 homodimer interface [polypeptide binding]; other site 1205677001402 SAM binding site [chemical binding]; other site 1205677001403 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1205677001404 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1205677001405 active site 1205677001406 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1205677001407 dimer interface [polypeptide binding]; other site 1205677001408 active site 1205677001409 Schiff base residues; other site 1205677001410 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677001411 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677001412 active site 1205677001413 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205677001414 anti sigma factor interaction site; other site 1205677001415 regulatory phosphorylation site [posttranslational modification]; other site 1205677001416 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205677001417 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1205677001418 active site 1205677001419 catalytic triad [active] 1205677001420 oxyanion hole [active] 1205677001421 HTH-like domain; Region: HTH_21; pfam13276 1205677001422 Integrase core domain; Region: rve; pfam00665 1205677001423 Transposase; Region: HTH_Tnp_1; pfam01527 1205677001424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205677001425 PE family; Region: PE; pfam00934 1205677001426 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205677001427 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677001428 PPE family; Region: PPE; pfam00823 1205677001429 Sec24-related protein; Provisional; Region: PTZ00395 1205677001430 Domain of unknown function (DUF385); Region: DUF385; cl04387 1205677001431 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1205677001432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205677001433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677001434 catalytic residue [active] 1205677001435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677001436 catalytic core [active] 1205677001437 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1205677001438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205677001439 catalytic residues [active] 1205677001440 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205677001441 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205677001442 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1205677001443 ResB-like family; Region: ResB; pfam05140 1205677001444 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1205677001445 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205677001446 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205677001447 P-loop; other site 1205677001448 Magnesium ion binding site [ion binding]; other site 1205677001449 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1205677001450 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1205677001451 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1205677001452 dimer interface [polypeptide binding]; other site 1205677001453 active site 1205677001454 CoA binding pocket [chemical binding]; other site 1205677001455 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205677001456 putative active site [active] 1205677001457 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1205677001458 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205677001459 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1205677001460 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205677001461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677001462 NAD(P) binding site [chemical binding]; other site 1205677001463 active site 1205677001464 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1205677001465 Ligand binding site; other site 1205677001466 Putative Catalytic site; other site 1205677001467 DXD motif; other site 1205677001468 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1205677001469 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1205677001470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677001471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677001472 acyl-activating enzyme (AAE) consensus motif; other site 1205677001473 acyl-activating enzyme (AAE) consensus motif; other site 1205677001474 AMP binding site [chemical binding]; other site 1205677001475 active site 1205677001476 CoA binding site [chemical binding]; other site 1205677001477 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1205677001478 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205677001479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677001480 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205677001481 active site 1205677001482 short chain dehydrogenase; Provisional; Region: PRK05866 1205677001483 classical (c) SDRs; Region: SDR_c; cd05233 1205677001484 NAD(P) binding site [chemical binding]; other site 1205677001485 active site 1205677001486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677001487 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1205677001488 substrate binding site [chemical binding]; other site 1205677001489 oxyanion hole (OAH) forming residues; other site 1205677001490 trimer interface [polypeptide binding]; other site 1205677001491 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205677001492 putative active site [active] 1205677001493 homotetrameric interface [polypeptide binding]; other site 1205677001494 metal binding site [ion binding]; metal-binding site 1205677001495 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1205677001496 acyl-CoA synthetase; Validated; Region: PRK06188 1205677001497 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205677001498 putative active site [active] 1205677001499 putative CoA binding site [chemical binding]; other site 1205677001500 putative AMP binding site [chemical binding]; other site 1205677001501 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1205677001502 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1205677001503 active site 1205677001504 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1205677001505 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1205677001506 active site 1205677001507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677001508 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205677001509 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205677001510 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1205677001511 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1205677001512 dimer interface [polypeptide binding]; other site 1205677001513 tetramer interface [polypeptide binding]; other site 1205677001514 PYR/PP interface [polypeptide binding]; other site 1205677001515 TPP binding site [chemical binding]; other site 1205677001516 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1205677001517 TPP-binding site; other site 1205677001518 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1205677001519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205677001520 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1205677001521 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1205677001522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001523 S-adenosylmethionine binding site [chemical binding]; other site 1205677001524 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677001525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001526 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677001527 S-adenosylmethionine binding site [chemical binding]; other site 1205677001528 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1205677001529 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205677001530 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205677001531 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205677001532 substrate binding pocket [chemical binding]; other site 1205677001533 chain length determination region; other site 1205677001534 substrate-Mg2+ binding site; other site 1205677001535 catalytic residues [active] 1205677001536 aspartate-rich region 1; other site 1205677001537 active site lid residues [active] 1205677001538 aspartate-rich region 2; other site 1205677001539 heat shock protein HtpX; Provisional; Region: PRK03072 1205677001540 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1205677001541 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205677001542 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1205677001543 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205677001544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205677001545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1205677001546 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1205677001547 O-methyltransferase; Region: Methyltransf_2; pfam00891 1205677001548 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677001549 Cytochrome P450; Region: p450; cl12078 1205677001550 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205677001551 ATP cone domain; Region: ATP-cone; pfam03477 1205677001552 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1205677001553 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1205677001554 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1205677001555 active site 1205677001556 dimer interface [polypeptide binding]; other site 1205677001557 effector binding site; other site 1205677001558 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1205677001559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677001560 active site 1205677001561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205677001562 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1205677001563 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1205677001564 active site 1205677001565 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1205677001566 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1205677001567 putative active site [active] 1205677001568 putative metal binding site [ion binding]; other site 1205677001569 hypothetical protein; Provisional; Region: PRK07588 1205677001570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205677001571 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1205677001572 ABC1 family; Region: ABC1; pfam03109 1205677001573 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677001574 Cytochrome P450; Region: p450; cl12078 1205677001575 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1205677001576 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205677001577 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677001578 Cytochrome P450; Region: p450; cl12078 1205677001579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677001580 dimerization interface [polypeptide binding]; other site 1205677001581 putative DNA binding site [nucleotide binding]; other site 1205677001582 putative Zn2+ binding site [ion binding]; other site 1205677001583 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1205677001584 putative hydrophobic ligand binding site [chemical binding]; other site 1205677001585 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205677001586 TIGR03086 family protein; Region: TIGR03086 1205677001587 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205677001588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677001589 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205677001590 PE family; Region: PE; pfam00934 1205677001591 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1205677001592 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1205677001593 Protein of unknown function DUF82; Region: DUF82; pfam01927 1205677001594 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677001595 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205677001596 putative active site [active] 1205677001597 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205677001598 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1205677001599 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1205677001600 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1205677001601 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205677001602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677001603 DNA-binding site [nucleotide binding]; DNA binding site 1205677001604 FCD domain; Region: FCD; pfam07729 1205677001605 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677001606 Permease; Region: Permease; pfam02405 1205677001607 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677001608 Permease; Region: Permease; pfam02405 1205677001609 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677001610 mce related protein; Region: MCE; pfam02470 1205677001611 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677001612 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1205677001613 mce related protein; Region: MCE; pfam02470 1205677001614 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677001615 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677001616 mce related protein; Region: MCE; pfam02470 1205677001617 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677001618 mce related protein; Region: MCE; pfam02470 1205677001619 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677001620 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677001621 mce related protein; Region: MCE; pfam02470 1205677001622 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677001623 mce related protein; Region: MCE; pfam02470 1205677001624 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205677001625 oligomeric interface; other site 1205677001626 putative active site [active] 1205677001627 homodimer interface [polypeptide binding]; other site 1205677001628 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205677001629 AAA domain; Region: AAA_14; pfam13173 1205677001630 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1205677001631 Part of AAA domain; Region: AAA_19; pfam13245 1205677001632 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1205677001633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677001634 Walker A/P-loop; other site 1205677001635 ATP binding site [chemical binding]; other site 1205677001636 DNA methylase; Region: N6_N4_Mtase; cl17433 1205677001637 DNA methylase; Region: N6_N4_Mtase; pfam01555 1205677001638 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1205677001639 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1205677001640 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1205677001641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677001642 Walker A motif; other site 1205677001643 ATP binding site [chemical binding]; other site 1205677001644 Walker B motif; other site 1205677001645 arginine finger; other site 1205677001646 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1205677001647 active site 1205677001648 catalytic triad [active] 1205677001649 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1205677001650 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205677001651 AAA domain; Region: AAA_14; pfam13173 1205677001652 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1205677001653 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1205677001654 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205677001655 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205677001656 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1205677001657 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205677001658 putative active site [active] 1205677001659 SEC-C motif; Region: SEC-C; pfam02810 1205677001660 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205677001661 putative active site [active] 1205677001662 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1205677001663 dimer interface [polypeptide binding]; other site 1205677001664 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1205677001665 active site 1205677001666 galactokinase; Provisional; Region: PRK00555 1205677001667 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1205677001668 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677001669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205677001670 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205677001671 putative active site [active] 1205677001672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677001673 AAA domain; Region: AAA_21; pfam13304 1205677001674 Walker A/P-loop; other site 1205677001675 ATP binding site [chemical binding]; other site 1205677001676 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1205677001677 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205677001678 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205677001679 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15993073 1205677001680 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15993073 1205677001681 Evidence 4 : Homologs of previously reported genes of unknown function 1205677001682 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205677001683 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677001684 putative active site [active] 1205677001685 FIST N domain; Region: FIST; pfam08495 1205677001686 FIST C domain; Region: FIST_C; pfam10442 1205677001687 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1205677001688 AAA domain; Region: AAA_30; pfam13604 1205677001689 Family description; Region: UvrD_C_2; pfam13538 1205677001690 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1205677001691 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1205677001692 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1205677001693 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1205677001694 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205677001695 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677001696 substrate binding site [chemical binding]; other site 1205677001697 oxyanion hole (OAH) forming residues; other site 1205677001698 trimer interface [polypeptide binding]; other site 1205677001699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205677001700 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205677001701 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1205677001702 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205677001703 active site 1205677001704 catalytic site [active] 1205677001705 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1205677001706 active site 1205677001707 catalytic site [active] 1205677001708 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205677001709 active site 1205677001710 catalytic site [active] 1205677001711 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1205677001712 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1205677001713 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1205677001714 putative homodimer interface [polypeptide binding]; other site 1205677001715 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1205677001716 heterodimer interface [polypeptide binding]; other site 1205677001717 homodimer interface [polypeptide binding]; other site 1205677001718 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1205677001719 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1205677001720 23S rRNA interface [nucleotide binding]; other site 1205677001721 L7/L12 interface [polypeptide binding]; other site 1205677001722 putative thiostrepton binding site; other site 1205677001723 L25 interface [polypeptide binding]; other site 1205677001724 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1205677001725 mRNA/rRNA interface [nucleotide binding]; other site 1205677001726 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001728 S-adenosylmethionine binding site [chemical binding]; other site 1205677001729 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001731 S-adenosylmethionine binding site [chemical binding]; other site 1205677001732 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677001734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001735 S-adenosylmethionine binding site [chemical binding]; other site 1205677001736 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677001737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677001738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677001739 S-adenosylmethionine binding site [chemical binding]; other site 1205677001740 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677001741 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205677001742 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1205677001743 ABC1 family; Region: ABC1; cl17513 1205677001744 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1205677001745 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1205677001746 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1205677001747 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1205677001748 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205677001749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205677001750 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1205677001751 23S rRNA interface [nucleotide binding]; other site 1205677001752 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1205677001753 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1205677001754 core dimer interface [polypeptide binding]; other site 1205677001755 peripheral dimer interface [polypeptide binding]; other site 1205677001756 L10 interface [polypeptide binding]; other site 1205677001757 L11 interface [polypeptide binding]; other site 1205677001758 putative EF-Tu interaction site [polypeptide binding]; other site 1205677001759 putative EF-G interaction site [polypeptide binding]; other site 1205677001760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677001761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677001762 WHG domain; Region: WHG; pfam13305 1205677001763 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1205677001764 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1205677001765 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1205677001766 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1205677001767 Walker A/P-loop; other site 1205677001768 ATP binding site [chemical binding]; other site 1205677001769 Q-loop/lid; other site 1205677001770 ABC transporter signature motif; other site 1205677001771 Walker B; other site 1205677001772 D-loop; other site 1205677001773 H-loop/switch region; other site 1205677001774 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677001775 putative active site [active] 1205677001776 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205677001777 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1205677001778 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205677001779 Evidence 5 : No homology to any previously reported sequences; PubMedId : 12657046, 15993073 1205677001780 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15993073 1205677001781 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205677001782 Sulfatase; Region: Sulfatase; pfam00884 1205677001783 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205677001784 Evidence 4 : Homologs of previously reported genes of unknown function 1205677001785 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205677001786 oligomeric interface; other site 1205677001787 putative active site [active] 1205677001788 homodimer interface [polypeptide binding]; other site 1205677001789 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1205677001790 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1205677001791 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1205677001792 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1205677001793 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1205677001794 RPB10 interaction site [polypeptide binding]; other site 1205677001795 RPB1 interaction site [polypeptide binding]; other site 1205677001796 RPB11 interaction site [polypeptide binding]; other site 1205677001797 RPB3 interaction site [polypeptide binding]; other site 1205677001798 RPB12 interaction site [polypeptide binding]; other site 1205677001799 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1205677001800 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1205677001801 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1205677001802 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1205677001803 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1205677001804 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1205677001805 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1205677001806 G-loop; other site 1205677001807 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1205677001808 DNA binding site [nucleotide binding] 1205677001809 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1205677001810 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1205677001811 endonuclease IV; Provisional; Region: PRK01060 1205677001812 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1205677001813 AP (apurinic/apyrimidinic) site pocket; other site 1205677001814 DNA interaction; other site 1205677001815 Metal-binding active site; metal-binding site 1205677001816 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1205677001817 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677001818 active site 1205677001819 enoyl-CoA hydratase; Provisional; Region: PRK12478 1205677001820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677001821 substrate binding site [chemical binding]; other site 1205677001822 oxyanion hole (OAH) forming residues; other site 1205677001823 trimer interface [polypeptide binding]; other site 1205677001824 PaaX-like protein; Region: PaaX; pfam07848 1205677001825 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1205677001826 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205677001827 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677001828 substrate binding site [chemical binding]; other site 1205677001829 oxyanion hole (OAH) forming residues; other site 1205677001830 trimer interface [polypeptide binding]; other site 1205677001831 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677001832 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205677001833 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205677001834 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205677001835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677001836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677001837 WHG domain; Region: WHG; pfam13305 1205677001838 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1205677001839 S17 interaction site [polypeptide binding]; other site 1205677001840 S8 interaction site; other site 1205677001841 16S rRNA interaction site [nucleotide binding]; other site 1205677001842 streptomycin interaction site [chemical binding]; other site 1205677001843 23S rRNA interaction site [nucleotide binding]; other site 1205677001844 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1205677001845 30S ribosomal protein S7; Validated; Region: PRK05302 1205677001846 elongation factor G; Reviewed; Region: PRK00007 1205677001847 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1205677001848 G1 box; other site 1205677001849 putative GEF interaction site [polypeptide binding]; other site 1205677001850 GTP/Mg2+ binding site [chemical binding]; other site 1205677001851 Switch I region; other site 1205677001852 G2 box; other site 1205677001853 G3 box; other site 1205677001854 Switch II region; other site 1205677001855 G4 box; other site 1205677001856 G5 box; other site 1205677001857 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205677001858 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205677001859 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205677001860 elongation factor Tu; Reviewed; Region: PRK00049 1205677001861 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1205677001862 G1 box; other site 1205677001863 GEF interaction site [polypeptide binding]; other site 1205677001864 GTP/Mg2+ binding site [chemical binding]; other site 1205677001865 Switch I region; other site 1205677001866 G2 box; other site 1205677001867 G3 box; other site 1205677001868 Switch II region; other site 1205677001869 G4 box; other site 1205677001870 G5 box; other site 1205677001871 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205677001872 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1205677001873 Antibiotic Binding Site [chemical binding]; other site 1205677001874 Short C-terminal domain; Region: SHOCT; pfam09851 1205677001875 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1205677001876 classical (c) SDRs; Region: SDR_c; cd05233 1205677001877 NAD(P) binding site [chemical binding]; other site 1205677001878 active site 1205677001879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205677001880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677001881 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1205677001882 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205677001883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677001884 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1205677001885 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1205677001886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677001887 FeS/SAM binding site; other site 1205677001888 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1205677001889 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1205677001890 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205677001891 phosphate binding site [ion binding]; other site 1205677001892 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1205677001893 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1205677001894 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205677001895 Probable Catalytic site; other site 1205677001896 metal-binding site 1205677001897 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1205677001898 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205677001899 putative transposase OrfB; Reviewed; Region: PHA02517 1205677001900 HTH-like domain; Region: HTH_21; pfam13276 1205677001901 Integrase core domain; Region: rve; pfam00665 1205677001902 Integrase core domain; Region: rve_3; cl15866 1205677001903 Transposase; Region: HTH_Tnp_1; cl17663 1205677001904 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1205677001905 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1205677001906 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1205677001907 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1205677001908 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1205677001909 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1205677001910 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1205677001911 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1205677001912 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1205677001913 putative translocon binding site; other site 1205677001914 protein-rRNA interface [nucleotide binding]; other site 1205677001915 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1205677001916 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1205677001917 G-X-X-G motif; other site 1205677001918 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1205677001919 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1205677001920 23S rRNA interface [nucleotide binding]; other site 1205677001921 5S rRNA interface [nucleotide binding]; other site 1205677001922 putative antibiotic binding site [chemical binding]; other site 1205677001923 L25 interface [polypeptide binding]; other site 1205677001924 L27 interface [polypeptide binding]; other site 1205677001925 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1205677001926 putative translocon interaction site; other site 1205677001927 23S rRNA interface [nucleotide binding]; other site 1205677001928 signal recognition particle (SRP54) interaction site; other site 1205677001929 L23 interface [polypeptide binding]; other site 1205677001930 trigger factor interaction site; other site 1205677001931 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1205677001932 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205677001933 Sulfatase; Region: Sulfatase; pfam00884 1205677001934 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1205677001935 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1205677001936 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1205677001937 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1205677001938 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1205677001939 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1205677001940 RNA binding site [nucleotide binding]; other site 1205677001941 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1205677001942 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1205677001943 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1205677001944 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1205677001945 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1205677001946 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1205677001947 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205677001948 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205677001949 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1205677001950 5S rRNA interface [nucleotide binding]; other site 1205677001951 23S rRNA interface [nucleotide binding]; other site 1205677001952 L5 interface [polypeptide binding]; other site 1205677001953 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1205677001954 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1205677001955 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1205677001956 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1205677001957 23S rRNA binding site [nucleotide binding]; other site 1205677001958 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1205677001959 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1205677001960 tandem repeat interface [polypeptide binding]; other site 1205677001961 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1205677001962 oligomer interface [polypeptide binding]; other site 1205677001963 active site residues [active] 1205677001964 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1205677001965 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1205677001966 tandem repeat interface [polypeptide binding]; other site 1205677001967 oligomer interface [polypeptide binding]; other site 1205677001968 active site residues [active] 1205677001969 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1205677001970 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677001971 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677001972 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677001973 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677001974 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1205677001975 intersubunit interface [polypeptide binding]; other site 1205677001976 active site 1205677001977 Zn2+ binding site [ion binding]; other site 1205677001978 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1205677001979 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205677001980 NAD binding site [chemical binding]; other site 1205677001981 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1205677001982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205677001983 nucleotide binding site [chemical binding]; other site 1205677001984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205677001985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677001986 Coenzyme A binding pocket [chemical binding]; other site 1205677001987 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677001988 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677001989 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1205677001990 SecY translocase; Region: SecY; pfam00344 1205677001991 adenylate kinase; Reviewed; Region: adk; PRK00279 1205677001992 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1205677001993 AMP-binding site [chemical binding]; other site 1205677001994 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1205677001995 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205677001996 active site 1205677001997 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1205677001998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677001999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677002000 DNA binding residues [nucleotide binding] 1205677002001 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1205677002002 Putative zinc-finger; Region: zf-HC2; pfam13490 1205677002003 MarR family; Region: MarR; pfam01047 1205677002004 TIGR03086 family protein; Region: TIGR03086 1205677002005 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205677002006 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205677002007 Helix-turn-helix domain; Region: HTH_17; pfam12728 1205677002008 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1205677002009 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677002010 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205677002011 putative active site [active] 1205677002012 Transposase; Region: HTH_Tnp_1; cl17663 1205677002013 putative transposase OrfB; Reviewed; Region: PHA02517 1205677002014 HTH-like domain; Region: HTH_21; pfam13276 1205677002015 Integrase core domain; Region: rve; pfam00665 1205677002016 Integrase core domain; Region: rve_3; cl15866 1205677002017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205677002018 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1205677002019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677002020 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1205677002021 substrate binding pocket [chemical binding]; other site 1205677002022 FAD binding site [chemical binding]; other site 1205677002023 catalytic base [active] 1205677002024 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1205677002025 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1205677002026 tetrameric interface [polypeptide binding]; other site 1205677002027 NAD binding site [chemical binding]; other site 1205677002028 catalytic residues [active] 1205677002029 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677002030 catalytic core [active] 1205677002031 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205677002032 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677002033 PPE family; Region: PPE; pfam00823 1205677002034 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677002035 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677002036 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1205677002037 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1205677002038 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1205677002039 PemK-like protein; Region: PemK; pfam02452 1205677002040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677002041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677002042 active site 1205677002043 phosphorylation site [posttranslational modification] 1205677002044 intermolecular recognition site; other site 1205677002045 dimerization interface [polypeptide binding]; other site 1205677002046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677002047 DNA binding site [nucleotide binding] 1205677002048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205677002049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677002050 dimerization interface [polypeptide binding]; other site 1205677002051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677002052 dimer interface [polypeptide binding]; other site 1205677002053 phosphorylation site [posttranslational modification] 1205677002054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677002055 ATP binding site [chemical binding]; other site 1205677002056 Mg2+ binding site [ion binding]; other site 1205677002057 G-X-G motif; other site 1205677002058 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1205677002059 nucleotide binding site/active site [active] 1205677002060 HIT family signature motif; other site 1205677002061 catalytic residue [active] 1205677002062 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1205677002063 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1205677002064 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205677002065 NAD binding site [chemical binding]; other site 1205677002066 catalytic Zn binding site [ion binding]; other site 1205677002067 substrate binding site [chemical binding]; other site 1205677002068 structural Zn binding site [ion binding]; other site 1205677002069 SnoaL-like domain; Region: SnoaL_3; pfam13474 1205677002070 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205677002071 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205677002072 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677002073 Cytochrome P450; Region: p450; cl12078 1205677002074 short chain dehydrogenase; Provisional; Region: PRK07775 1205677002075 classical (c) SDRs; Region: SDR_c; cd05233 1205677002076 NAD(P) binding site [chemical binding]; other site 1205677002077 active site 1205677002078 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677002079 Cytochrome P450; Region: p450; cl12078 1205677002080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677002081 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1205677002082 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1205677002083 NAD binding site [chemical binding]; other site 1205677002084 catalytic residues [active] 1205677002085 short chain dehydrogenase; Provisional; Region: PRK07774 1205677002086 classical (c) SDRs; Region: SDR_c; cd05233 1205677002087 NAD(P) binding site [chemical binding]; other site 1205677002088 active site 1205677002089 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205677002090 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1205677002091 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1205677002092 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1205677002093 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1205677002094 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1205677002095 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1205677002096 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1205677002097 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1205677002098 Predicted esterase [General function prediction only]; Region: COG0627 1205677002099 S-formylglutathione hydrolase; Region: PLN02442 1205677002100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205677002101 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1205677002102 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1205677002103 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1205677002104 tetramer interface [polypeptide binding]; other site 1205677002105 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677002106 Cytochrome P450; Region: p450; cl12078 1205677002107 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1205677002108 ATP binding site [chemical binding]; other site 1205677002109 active site 1205677002110 substrate binding site [chemical binding]; other site 1205677002111 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1205677002112 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677002113 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205677002114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677002115 putative substrate translocation pore; other site 1205677002116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677002117 Predicted deacetylase [General function prediction only]; Region: COG3233 1205677002118 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1205677002119 putative active site [active] 1205677002120 putative Zn binding site [ion binding]; other site 1205677002121 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205677002122 FAD binding domain; Region: FAD_binding_2; pfam00890 1205677002123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205677002124 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1205677002125 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1205677002126 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1205677002127 putative active site [active] 1205677002128 catalytic triad [active] 1205677002129 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205677002130 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205677002131 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677002132 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205677002133 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205677002134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677002135 DNA-binding site [nucleotide binding]; DNA binding site 1205677002136 UTRA domain; Region: UTRA; pfam07702 1205677002137 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205677002138 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1205677002139 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205677002140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677002141 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205677002142 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1205677002143 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1205677002144 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1205677002145 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1205677002146 active site 1205677002147 metal binding site [ion binding]; metal-binding site 1205677002148 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205677002149 active site 1205677002150 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205677002151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205677002152 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1205677002153 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1205677002154 dimerization interface [polypeptide binding]; other site 1205677002155 ATP binding site [chemical binding]; other site 1205677002156 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1205677002157 dimerization interface [polypeptide binding]; other site 1205677002158 ATP binding site [chemical binding]; other site 1205677002159 CAAX protease self-immunity; Region: Abi; pfam02517 1205677002160 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205677002161 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1205677002162 active site 1205677002163 metal binding site [ion binding]; metal-binding site 1205677002164 hexamer interface [polypeptide binding]; other site 1205677002165 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1205677002166 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1205677002167 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1205677002168 active site 1205677002169 tetramer interface [polypeptide binding]; other site 1205677002170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677002171 active site 1205677002172 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1205677002173 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1205677002174 dimerization interface [polypeptide binding]; other site 1205677002175 putative ATP binding site [chemical binding]; other site 1205677002176 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1205677002177 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1205677002178 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1205677002179 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1205677002180 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1205677002181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677002182 catalytic residue [active] 1205677002183 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1205677002184 heme-binding site [chemical binding]; other site 1205677002185 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1205677002186 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205677002187 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205677002188 active site residue [active] 1205677002189 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type pe : putative enzyme 1205677002190 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205677002191 catalytic residues [active] 1205677002192 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205677002193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677002194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677002195 DNA binding site [nucleotide binding] 1205677002196 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1205677002197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677002198 Coenzyme A binding pocket [chemical binding]; other site 1205677002199 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1205677002200 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205677002201 Walker A/P-loop; other site 1205677002202 ATP binding site [chemical binding]; other site 1205677002203 Q-loop/lid; other site 1205677002204 ABC transporter signature motif; other site 1205677002205 Walker B; other site 1205677002206 D-loop; other site 1205677002207 H-loop/switch region; other site 1205677002208 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1205677002209 PhoU domain; Region: PhoU; pfam01895 1205677002210 PhoU domain; Region: PhoU; pfam01895 1205677002211 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1205677002212 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205677002213 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1205677002214 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1205677002215 FMN binding site [chemical binding]; other site 1205677002216 active site 1205677002217 catalytic residues [active] 1205677002218 substrate binding site [chemical binding]; other site 1205677002219 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1205677002220 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1205677002221 homodimer interface [polypeptide binding]; other site 1205677002222 putative substrate binding pocket [chemical binding]; other site 1205677002223 diiron center [ion binding]; other site 1205677002224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677002225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205677002226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677002227 dimerization interface [polypeptide binding]; other site 1205677002228 putative DNA binding site [nucleotide binding]; other site 1205677002229 putative Zn2+ binding site [ion binding]; other site 1205677002230 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590 1205677002231 active site 1205677002232 Zn binding site [ion binding]; other site 1205677002233 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677002234 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677002235 TIGR04255 family protein; Region: sporadTIGR04255 1205677002236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205677002237 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677002238 Winged helix-turn helix; Region: HTH_29; pfam13551 1205677002239 Homeodomain-like domain; Region: HTH_32; pfam13565 1205677002240 Integrase core domain; Region: rve; pfam00665 1205677002241 Integrase core domain; Region: rve_3; pfam13683 1205677002242 Protein of unknown function (DUF433); Region: DUF433; cl01030 1205677002243 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1205677002244 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1205677002245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1205677002246 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1205677002247 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1205677002248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1205677002249 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1205677002250 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1205677002251 PE family; Region: PE; pfam00934 1205677002252 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677002253 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1205677002254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1205677002255 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1205677002256 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1205677002257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677002258 S-adenosylmethionine binding site [chemical binding]; other site 1205677002259 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1205677002260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677002261 putative substrate translocation pore; other site 1205677002262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205677002263 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1205677002264 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205677002265 tetramer interface [polypeptide binding]; other site 1205677002266 TPP-binding site [chemical binding]; other site 1205677002267 heterodimer interface [polypeptide binding]; other site 1205677002268 phosphorylation loop region [posttranslational modification] 1205677002269 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677002270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677002271 active site 1205677002272 phosphorylation site [posttranslational modification] 1205677002273 intermolecular recognition site; other site 1205677002274 dimerization interface [polypeptide binding]; other site 1205677002275 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677002276 DNA binding residues [nucleotide binding] 1205677002277 dimerization interface [polypeptide binding]; other site 1205677002278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205677002279 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205677002280 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1205677002281 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1205677002282 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1205677002283 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1205677002284 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205677002285 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205677002286 dimer interface [polypeptide binding]; other site 1205677002287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677002288 catalytic residue [active] 1205677002289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677002290 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1205677002291 putative substrate translocation pore; other site 1205677002292 short chain dehydrogenase; Provisional; Region: PRK05876 1205677002293 classical (c) SDRs; Region: SDR_c; cd05233 1205677002294 NAD(P) binding site [chemical binding]; other site 1205677002295 active site 1205677002296 Integrase core domain; Region: rve; pfam00665 1205677002297 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677002298 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1205677002299 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1205677002300 dimer interface [polypeptide binding]; other site 1205677002301 PYR/PP interface [polypeptide binding]; other site 1205677002302 TPP binding site [chemical binding]; other site 1205677002303 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205677002304 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1205677002305 TPP-binding site [chemical binding]; other site 1205677002306 dimer interface [polypeptide binding]; other site 1205677002307 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205677002308 putative hydrophobic ligand binding site [chemical binding]; other site 1205677002309 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205677002310 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205677002311 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205677002312 putative hydrophobic ligand binding site [chemical binding]; other site 1205677002313 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205677002314 putative hydrophobic ligand binding site [chemical binding]; other site 1205677002315 aminotransferase; Validated; Region: PRK07777 1205677002316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677002317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677002318 homodimer interface [polypeptide binding]; other site 1205677002319 catalytic residue [active] 1205677002320 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1205677002321 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205677002322 dimer interface [polypeptide binding]; other site 1205677002323 active site 1205677002324 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1205677002325 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677002326 substrate binding site [chemical binding]; other site 1205677002327 oxyanion hole (OAH) forming residues; other site 1205677002328 trimer interface [polypeptide binding]; other site 1205677002329 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205677002330 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205677002331 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205677002332 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205677002333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677002334 ATP binding site [chemical binding]; other site 1205677002335 putative Mg++ binding site [ion binding]; other site 1205677002336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677002337 nucleotide binding region [chemical binding]; other site 1205677002338 ATP-binding site [chemical binding]; other site 1205677002339 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205677002340 WYL domain; Region: WYL; pfam13280 1205677002341 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205677002342 trimer interface [polypeptide binding]; other site 1205677002343 dimer interface [polypeptide binding]; other site 1205677002344 putative active site [active] 1205677002345 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1205677002346 MPT binding site; other site 1205677002347 trimer interface [polypeptide binding]; other site 1205677002348 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205677002349 MoaE homodimer interface [polypeptide binding]; other site 1205677002350 MoaD interaction [polypeptide binding]; other site 1205677002351 active site residues [active] 1205677002352 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205677002353 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205677002354 MoaE interaction surface [polypeptide binding]; other site 1205677002355 MoeB interaction surface [polypeptide binding]; other site 1205677002356 thiocarboxylated glycine; other site 1205677002357 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1205677002358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677002359 FeS/SAM binding site; other site 1205677002360 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205677002361 hypothetical protein; Provisional; Region: PRK11770 1205677002362 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205677002363 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205677002364 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205677002365 DNA-binding site [nucleotide binding]; DNA binding site 1205677002366 RNA-binding motif; other site 1205677002367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677002368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677002369 active site 1205677002370 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1205677002371 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205677002372 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1205677002373 PPE family; Region: PPE; pfam00823 1205677002374 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677002375 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677002376 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677002377 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1205677002378 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205677002379 MarR family; Region: MarR; pfam01047 1205677002380 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205677002381 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205677002382 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205677002383 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1205677002384 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1205677002385 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1205677002386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677002387 catalytic residue [active] 1205677002388 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1205677002389 Ferredoxin [Energy production and conversion]; Region: COG1146 1205677002390 4Fe-4S binding domain; Region: Fer4; pfam00037 1205677002391 ferredoxin-NADP+ reductase; Region: PLN02852 1205677002392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677002393 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1205677002394 putative dimer interface [polypeptide binding]; other site 1205677002395 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677002396 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1205677002397 putative catalytic site [active] 1205677002398 putative phosphate binding site [ion binding]; other site 1205677002399 putative metal binding site [ion binding]; other site 1205677002400 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1205677002401 dimer interface [polypeptide binding]; other site 1205677002402 Citrate synthase; Region: Citrate_synt; pfam00285 1205677002403 active site 1205677002404 citrylCoA binding site [chemical binding]; other site 1205677002405 oxalacetate/citrate binding site [chemical binding]; other site 1205677002406 coenzyme A binding site [chemical binding]; other site 1205677002407 catalytic triad [active] 1205677002408 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677002409 cyclase homology domain; Region: CHD; cd07302 1205677002410 nucleotidyl binding site; other site 1205677002411 metal binding site [ion binding]; metal-binding site 1205677002412 dimer interface [polypeptide binding]; other site 1205677002413 AAA ATPase domain; Region: AAA_16; pfam13191 1205677002414 Predicted ATPase [General function prediction only]; Region: COG3903 1205677002415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677002416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677002417 DNA binding residues [nucleotide binding] 1205677002418 dimerization interface [polypeptide binding]; other site 1205677002419 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205677002420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205677002421 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677002422 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677002423 AAA ATPase domain; Region: AAA_16; pfam13191 1205677002424 Predicted ATPase [General function prediction only]; Region: COG3903 1205677002425 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677002426 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677002427 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1205677002428 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1205677002429 dimer interface [polypeptide binding]; other site 1205677002430 active site 1205677002431 citrylCoA binding site [chemical binding]; other site 1205677002432 NADH binding [chemical binding]; other site 1205677002433 cationic pore residues; other site 1205677002434 oxalacetate/citrate binding site [chemical binding]; other site 1205677002435 coenzyme A binding site [chemical binding]; other site 1205677002436 catalytic triad [active] 1205677002437 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205677002438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677002439 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1205677002440 BON domain; Region: BON; pfam04972 1205677002441 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1205677002442 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1205677002443 ligand binding site [chemical binding]; other site 1205677002444 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1205677002445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205677002446 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677002447 dimerization interface [polypeptide binding]; other site 1205677002448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677002449 dimer interface [polypeptide binding]; other site 1205677002450 phosphorylation site [posttranslational modification] 1205677002451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677002452 Mg2+ binding site [ion binding]; other site 1205677002453 G-X-G motif; other site 1205677002454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677002455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677002456 active site 1205677002457 phosphorylation site [posttranslational modification] 1205677002458 intermolecular recognition site; other site 1205677002459 dimerization interface [polypeptide binding]; other site 1205677002460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677002461 DNA binding site [nucleotide binding] 1205677002462 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1205677002463 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1205677002464 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205677002465 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677002466 substrate binding site [chemical binding]; other site 1205677002467 oxyanion hole (OAH) forming residues; other site 1205677002468 trimer interface [polypeptide binding]; other site 1205677002469 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205677002470 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1205677002471 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677002472 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677002473 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1205677002474 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205677002475 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677002476 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205677002477 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1205677002478 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205677002479 hydrophobic ligand binding site; other site 1205677002480 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205677002481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677002482 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205677002483 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677002484 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1205677002485 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1205677002486 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1205677002487 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205677002488 active site 1205677002489 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677002490 PPE family; Region: PPE; pfam00823 1205677002491 PE family; Region: PE; pfam00934 1205677002492 BCCT family transporter; Region: BCCT; pfam02028 1205677002493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1205677002494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677002495 Coenzyme A binding pocket [chemical binding]; other site 1205677002496 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1205677002497 putative active site pocket [active] 1205677002498 dimerization interface [polypeptide binding]; other site 1205677002499 putative catalytic residue [active] 1205677002500 Phage-related replication protein [General function prediction only]; Region: COG4195 1205677002501 manganese transport protein MntH; Reviewed; Region: PRK00701 1205677002502 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1205677002503 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1205677002504 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205677002505 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1205677002506 short chain dehydrogenase; Provisional; Region: PRK07814 1205677002507 classical (c) SDRs; Region: SDR_c; cd05233 1205677002508 NAD(P) binding site [chemical binding]; other site 1205677002509 active site 1205677002510 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1205677002511 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1205677002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677002513 dimer interface [polypeptide binding]; other site 1205677002514 conserved gate region; other site 1205677002515 putative PBP binding loops; other site 1205677002516 ABC-ATPase subunit interface; other site 1205677002517 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1205677002518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677002519 dimer interface [polypeptide binding]; other site 1205677002520 conserved gate region; other site 1205677002521 putative PBP binding loops; other site 1205677002522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205677002523 ABC-ATPase subunit interface; other site 1205677002524 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677002525 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677002526 active site 1205677002527 ATP binding site [chemical binding]; other site 1205677002528 substrate binding site [chemical binding]; other site 1205677002529 activation loop (A-loop); other site 1205677002530 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205677002531 NHL repeat; Region: NHL; pfam01436 1205677002532 NHL repeat; Region: NHL; pfam01436 1205677002533 NHL repeat; Region: NHL; pfam01436 1205677002534 NHL repeat; Region: NHL; pfam01436 1205677002535 NHL repeat; Region: NHL; pfam01436 1205677002536 PBP superfamily domain; Region: PBP_like_2; cl17296 1205677002537 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1205677002538 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205677002539 Walker A/P-loop; other site 1205677002540 ATP binding site [chemical binding]; other site 1205677002541 Q-loop/lid; other site 1205677002542 ABC transporter signature motif; other site 1205677002543 Walker B; other site 1205677002544 D-loop; other site 1205677002545 H-loop/switch region; other site 1205677002546 PBP superfamily domain; Region: PBP_like_2; cl17296 1205677002547 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1205677002548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677002549 dimer interface [polypeptide binding]; other site 1205677002550 conserved gate region; other site 1205677002551 putative PBP binding loops; other site 1205677002552 ABC-ATPase subunit interface; other site 1205677002553 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1205677002554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677002555 dimer interface [polypeptide binding]; other site 1205677002556 conserved gate region; other site 1205677002557 putative PBP binding loops; other site 1205677002558 ABC-ATPase subunit interface; other site 1205677002559 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1205677002560 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1205677002561 putative DNA binding site [nucleotide binding]; other site 1205677002562 putative homodimer interface [polypeptide binding]; other site 1205677002563 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1205677002564 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1205677002565 nucleotide binding site [chemical binding]; other site 1205677002566 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1205677002567 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1205677002568 active site 1205677002569 DNA binding site [nucleotide binding] 1205677002570 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1205677002571 DNA binding site [nucleotide binding] 1205677002572 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1205677002573 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205677002574 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205677002575 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205677002576 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677002577 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205677002578 anti sigma factor interaction site; other site 1205677002579 regulatory phosphorylation site [posttranslational modification]; other site 1205677002580 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205677002581 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1205677002582 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1205677002583 homodimer interface [polypeptide binding]; other site 1205677002584 active site 1205677002585 SAM binding site [chemical binding]; other site 1205677002586 PE family; Region: PE; pfam00934 1205677002587 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205677002588 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1205677002589 putative DNA binding site [nucleotide binding]; other site 1205677002590 catalytic residue [active] 1205677002591 putative H2TH interface [polypeptide binding]; other site 1205677002592 putative catalytic residues [active] 1205677002593 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205677002594 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205677002595 short chain dehydrogenase; Provisional; Region: PRK08251 1205677002596 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1205677002597 putative NAD(P) binding site [chemical binding]; other site 1205677002598 active site 1205677002599 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1205677002600 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1205677002601 active site 1205677002602 dimer interface [polypeptide binding]; other site 1205677002603 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1205677002604 dimer interface [polypeptide binding]; other site 1205677002605 active site 1205677002606 Predicted esterase [General function prediction only]; Region: COG0627 1205677002607 hypothetical protein; Provisional; Region: PRK07857 1205677002608 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1205677002609 Part of AAA domain; Region: AAA_19; pfam13245 1205677002610 Family description; Region: UvrD_C_2; pfam13538 1205677002611 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205677002612 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205677002613 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1205677002614 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1205677002615 CoA-ligase; Region: Ligase_CoA; pfam00549 1205677002616 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1205677002617 CoA binding domain; Region: CoA_binding; smart00881 1205677002618 CoA-ligase; Region: Ligase_CoA; pfam00549 1205677002619 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205677002620 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677002621 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1205677002622 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1205677002623 active site 1205677002624 substrate binding site [chemical binding]; other site 1205677002625 cosubstrate binding site; other site 1205677002626 catalytic site [active] 1205677002627 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1205677002628 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1205677002629 purine monophosphate binding site [chemical binding]; other site 1205677002630 dimer interface [polypeptide binding]; other site 1205677002631 putative catalytic residues [active] 1205677002632 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1205677002633 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1205677002634 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1205677002635 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1205677002636 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1205677002637 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205677002638 metal ion-dependent adhesion site (MIDAS); other site 1205677002639 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205677002640 homotetrameric interface [polypeptide binding]; other site 1205677002641 putative active site [active] 1205677002642 metal binding site [ion binding]; metal-binding site 1205677002643 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205677002644 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205677002645 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1205677002646 putative homodimer interface [polypeptide binding]; other site 1205677002647 putative homotetramer interface [polypeptide binding]; other site 1205677002648 allosteric switch controlling residues; other site 1205677002649 putative metal binding site [ion binding]; other site 1205677002650 putative homodimer-homodimer interface [polypeptide binding]; other site 1205677002651 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205677002652 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1205677002653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677002654 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205677002655 enoyl-CoA hydratase; Provisional; Region: PRK07827 1205677002656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677002657 substrate binding site [chemical binding]; other site 1205677002658 oxyanion hole (OAH) forming residues; other site 1205677002659 trimer interface [polypeptide binding]; other site 1205677002660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677002661 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205677002662 active site 1205677002663 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205677002664 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205677002665 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205677002666 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205677002667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205677002668 carboxyltransferase (CT) interaction site; other site 1205677002669 biotinylation site [posttranslational modification]; other site 1205677002670 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205677002671 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205677002672 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205677002673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677002674 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677002675 active site 1205677002676 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1205677002677 PE family; Region: PE; pfam00934 1205677002678 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205677002679 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1205677002680 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205677002681 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205677002682 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205677002683 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205677002684 PE family; Region: PE; pfam00934 1205677002685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677002686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677002687 active site 1205677002688 phosphorylation site [posttranslational modification] 1205677002689 intermolecular recognition site; other site 1205677002690 dimerization interface [polypeptide binding]; other site 1205677002691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677002692 DNA binding site [nucleotide binding] 1205677002693 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205677002694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677002695 dimerization interface [polypeptide binding]; other site 1205677002696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677002697 dimer interface [polypeptide binding]; other site 1205677002698 phosphorylation site [posttranslational modification] 1205677002699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677002700 ATP binding site [chemical binding]; other site 1205677002701 Mg2+ binding site [ion binding]; other site 1205677002702 G-X-G motif; other site 1205677002703 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1205677002704 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205677002705 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1205677002706 MPT binding site; other site 1205677002707 trimer interface [polypeptide binding]; other site 1205677002708 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1205677002709 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1205677002710 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205677002711 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205677002712 Walker A/P-loop; other site 1205677002713 ATP binding site [chemical binding]; other site 1205677002714 Q-loop/lid; other site 1205677002715 ABC transporter signature motif; other site 1205677002716 Walker B; other site 1205677002717 D-loop; other site 1205677002718 H-loop/switch region; other site 1205677002719 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1205677002720 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205677002721 FtsX-like permease family; Region: FtsX; pfam02687 1205677002722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205677002723 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1205677002724 FtsX-like permease family; Region: FtsX; pfam02687 1205677002725 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1205677002726 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205677002727 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205677002728 substrate binding pocket [chemical binding]; other site 1205677002729 chain length determination region; other site 1205677002730 substrate-Mg2+ binding site; other site 1205677002731 catalytic residues [active] 1205677002732 aspartate-rich region 1; other site 1205677002733 active site lid residues [active] 1205677002734 aspartate-rich region 2; other site 1205677002735 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1205677002736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1205677002737 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1205677002738 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1205677002739 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1205677002740 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1205677002741 active site 1205677002742 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205677002743 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205677002744 dimer interface [polypeptide binding]; other site 1205677002745 putative functional site; other site 1205677002746 putative MPT binding site; other site 1205677002747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205677002748 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205677002749 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1205677002750 putative DNA binding helix; other site 1205677002751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677002752 S-adenosylmethionine binding site [chemical binding]; other site 1205677002753 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677002754 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677002755 ligand binding site [chemical binding]; other site 1205677002756 flexible hinge region; other site 1205677002757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205677002758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677002759 Coenzyme A binding pocket [chemical binding]; other site 1205677002760 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1205677002761 arginine deiminase; Provisional; Region: PRK01388 1205677002762 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1205677002763 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1205677002764 Predicted methyltransferases [General function prediction only]; Region: COG0313 1205677002765 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1205677002766 putative SAM binding site [chemical binding]; other site 1205677002767 putative homodimer interface [polypeptide binding]; other site 1205677002768 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1205677002769 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1205677002770 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1205677002771 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1205677002772 active site 1205677002773 HIGH motif; other site 1205677002774 KMSKS motif; other site 1205677002775 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1205677002776 tRNA binding surface [nucleotide binding]; other site 1205677002777 anticodon binding site; other site 1205677002778 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1205677002779 active site 1205677002780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1205677002781 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205677002782 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205677002783 G5 domain; Region: G5; pfam07501 1205677002784 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205677002785 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1205677002786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677002787 S-adenosylmethionine binding site [chemical binding]; other site 1205677002788 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1205677002789 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1205677002790 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1205677002791 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1205677002792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677002793 acyl-activating enzyme (AAE) consensus motif; other site 1205677002794 AMP binding site [chemical binding]; other site 1205677002795 active site 1205677002796 CoA binding site [chemical binding]; other site 1205677002797 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1205677002798 putative active site [active] 1205677002799 catalytic residue [active] 1205677002800 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1205677002801 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1205677002802 5S rRNA interface [nucleotide binding]; other site 1205677002803 CTC domain interface [polypeptide binding]; other site 1205677002804 L16 interface [polypeptide binding]; other site 1205677002805 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205677002806 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1205677002807 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1205677002808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677002809 active site 1205677002810 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1205677002811 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1205677002812 Substrate binding site; other site 1205677002813 Mg++ binding site; other site 1205677002814 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1205677002815 active site 1205677002816 substrate binding site [chemical binding]; other site 1205677002817 CoA binding site [chemical binding]; other site 1205677002818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677002819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677002820 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1205677002821 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1205677002822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677002823 ATP binding site [chemical binding]; other site 1205677002824 putative Mg++ binding site [ion binding]; other site 1205677002825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677002826 nucleotide binding region [chemical binding]; other site 1205677002827 ATP-binding site [chemical binding]; other site 1205677002828 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1205677002829 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1205677002830 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1205677002831 homodimer interface [polypeptide binding]; other site 1205677002832 metal binding site [ion binding]; metal-binding site 1205677002833 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1205677002834 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1205677002835 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205677002836 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205677002837 enolase; Provisional; Region: eno; PRK00077 1205677002838 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1205677002839 dimer interface [polypeptide binding]; other site 1205677002840 metal binding site [ion binding]; metal-binding site 1205677002841 substrate binding pocket [chemical binding]; other site 1205677002842 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1205677002843 Septum formation initiator; Region: DivIC; pfam04977 1205677002844 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1205677002845 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1205677002846 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1205677002847 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1205677002848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677002849 active site 1205677002850 phosphorylation site [posttranslational modification] 1205677002851 intermolecular recognition site; other site 1205677002852 dimerization interface [polypeptide binding]; other site 1205677002853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677002854 DNA binding site [nucleotide binding] 1205677002855 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1205677002856 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1205677002857 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1205677002858 Ligand Binding Site [chemical binding]; other site 1205677002859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677002860 dimer interface [polypeptide binding]; other site 1205677002861 phosphorylation site [posttranslational modification] 1205677002862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677002863 ATP binding site [chemical binding]; other site 1205677002864 Mg2+ binding site [ion binding]; other site 1205677002865 G-X-G motif; other site 1205677002866 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1205677002867 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1205677002868 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677002869 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205677002870 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1205677002871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205677002872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677002873 dimer interface [polypeptide binding]; other site 1205677002874 phosphorylation site [posttranslational modification] 1205677002875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677002876 ATP binding site [chemical binding]; other site 1205677002877 Mg2+ binding site [ion binding]; other site 1205677002878 G-X-G motif; other site 1205677002879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677002880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677002881 active site 1205677002882 phosphorylation site [posttranslational modification] 1205677002883 intermolecular recognition site; other site 1205677002884 dimerization interface [polypeptide binding]; other site 1205677002885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677002886 DNA binding site [nucleotide binding] 1205677002887 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205677002888 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205677002889 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677002890 PPE family; Region: PPE; pfam00823 1205677002891 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677002892 PE family; Region: PE; pfam00934 1205677002893 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677002894 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1205677002895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677002896 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1205677002897 Walker A motif; other site 1205677002898 ATP binding site [chemical binding]; other site 1205677002899 Walker B motif; other site 1205677002900 arginine finger; other site 1205677002901 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205677002902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677002903 ATP binding site [chemical binding]; other site 1205677002904 putative Mg++ binding site [ion binding]; other site 1205677002905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205677002906 ATP-binding site [chemical binding]; other site 1205677002907 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1205677002908 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12368446, 12657046, 12775759 1205677002909 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12368446, 12657046, 12775759 1205677002910 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205677002911 MarR family; Region: MarR_2; pfam12802 1205677002912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677002913 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205677002914 NAD(P) binding site [chemical binding]; other site 1205677002915 active site 1205677002916 PIN domain; Region: PIN_3; pfam13470 1205677002917 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205677002918 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205677002919 Fic/DOC family; Region: Fic; pfam02661 1205677002920 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205677002921 DNA binding site [nucleotide binding] 1205677002922 Int/Topo IB signature motif; other site 1205677002923 active site 1205677002924 Domain of unknown function (DUF427); Region: DUF427; cl00998 1205677002925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205677002926 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205677002927 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1205677002928 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1205677002929 dimer interface [polypeptide binding]; other site 1205677002930 acyl-activating enzyme (AAE) consensus motif; other site 1205677002931 putative active site [active] 1205677002932 AMP binding site [chemical binding]; other site 1205677002933 putative CoA binding site [chemical binding]; other site 1205677002934 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1205677002935 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1205677002936 hydrophobic ligand binding site; other site 1205677002937 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1205677002938 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1205677002939 putative active site [active] 1205677002940 putative dimer interface [polypeptide binding]; other site 1205677002941 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205677002942 hypothetical protein; Provisional; Region: PRK10279 1205677002943 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1205677002944 active site 1205677002945 nucleophile elbow; other site 1205677002946 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1205677002947 Rhodanese Homology Domain; Region: RHOD; smart00450 1205677002948 active site residue [active] 1205677002949 PE family; Region: PE; pfam00934 1205677002950 PE family; Region: PE; pfam00934 1205677002951 Predicted membrane protein [Function unknown]; Region: COG4425 1205677002952 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1205677002953 enoyl-CoA hydratase; Provisional; Region: PRK05862 1205677002954 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677002955 substrate binding site [chemical binding]; other site 1205677002956 oxyanion hole (OAH) forming residues; other site 1205677002957 trimer interface [polypeptide binding]; other site 1205677002958 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1205677002959 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1205677002960 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677002961 substrate binding site [chemical binding]; other site 1205677002962 oxyanion hole (OAH) forming residues; other site 1205677002963 trimer interface [polypeptide binding]; other site 1205677002964 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1205677002965 Predicted membrane protein [Function unknown]; Region: COG4760 1205677002966 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1205677002967 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1205677002968 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205677002969 dimer interface [polypeptide binding]; other site 1205677002970 active site 1205677002971 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1205677002972 active site 1205677002973 catalytic triad [active] 1205677002974 oxyanion hole [active] 1205677002975 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205677002976 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205677002977 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1205677002978 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205677002979 dimer interface [polypeptide binding]; other site 1205677002980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677002981 catalytic residue [active] 1205677002982 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1205677002983 RDD family; Region: RDD; pfam06271 1205677002984 cystathionine gamma-synthase; Provisional; Region: PRK07811 1205677002985 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205677002986 homodimer interface [polypeptide binding]; other site 1205677002987 substrate-cofactor binding pocket; other site 1205677002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677002989 catalytic residue [active] 1205677002990 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1205677002991 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1205677002992 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205677002993 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1205677002994 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1205677002995 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1205677002996 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1205677002997 catalytic residues [active] 1205677002998 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1205677002999 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1205677003000 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1205677003001 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1205677003002 catalytic residue [active] 1205677003003 putative FPP diphosphate binding site; other site 1205677003004 putative FPP binding hydrophobic cleft; other site 1205677003005 dimer interface [polypeptide binding]; other site 1205677003006 putative IPP diphosphate binding site; other site 1205677003007 PE family; Region: PE; pfam00934 1205677003008 PE family; Region: PE; pfam00934 1205677003009 pantothenate kinase; Provisional; Region: PRK05439 1205677003010 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1205677003011 ATP-binding site [chemical binding]; other site 1205677003012 CoA-binding site [chemical binding]; other site 1205677003013 Mg2+-binding site [ion binding]; other site 1205677003014 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1205677003015 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1205677003016 dimer interface [polypeptide binding]; other site 1205677003017 active site 1205677003018 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1205677003019 folate binding site [chemical binding]; other site 1205677003020 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1205677003021 dinuclear metal binding motif [ion binding]; other site 1205677003022 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1205677003023 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1205677003024 putative active site [active] 1205677003025 PhoH-like protein; Region: PhoH; pfam02562 1205677003026 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205677003027 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1205677003028 NodB motif; other site 1205677003029 active site 1205677003030 catalytic site [active] 1205677003031 metal binding site [ion binding]; metal-binding site 1205677003032 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1205677003033 Class II fumarases; Region: Fumarase_classII; cd01362 1205677003034 active site 1205677003035 tetramer interface [polypeptide binding]; other site 1205677003036 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1205677003037 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1205677003038 putative active site [active] 1205677003039 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1205677003040 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205677003041 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1205677003042 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205677003043 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677003044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677003045 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677003046 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677003047 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1205677003048 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1205677003049 putative NAD(P) binding site [chemical binding]; other site 1205677003050 active site 1205677003051 putative substrate binding site [chemical binding]; other site 1205677003052 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1205677003053 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1205677003054 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1205677003055 generic binding surface II; other site 1205677003056 generic binding surface I; other site 1205677003057 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1205677003058 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1205677003059 Yip1 domain; Region: Yip1; pfam04893 1205677003060 GTP-binding protein YchF; Reviewed; Region: PRK09601 1205677003061 YchF GTPase; Region: YchF; cd01900 1205677003062 G1 box; other site 1205677003063 GTP/Mg2+ binding site [chemical binding]; other site 1205677003064 Switch I region; other site 1205677003065 G2 box; other site 1205677003066 Switch II region; other site 1205677003067 G3 box; other site 1205677003068 G4 box; other site 1205677003069 G5 box; other site 1205677003070 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1205677003071 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1205677003072 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1205677003073 NlpC/P60 family; Region: NLPC_P60; cl17555 1205677003074 Integrase core domain; Region: rve; pfam00665 1205677003075 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205677003076 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205677003077 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205677003078 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1205677003079 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205677003080 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205677003081 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205677003082 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1205677003083 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205677003084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205677003085 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677003086 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677003087 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677003088 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1205677003089 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205677003090 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1205677003091 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677003092 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677003093 active site 1205677003094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205677003095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677003096 non-specific DNA binding site [nucleotide binding]; other site 1205677003097 salt bridge; other site 1205677003098 sequence-specific DNA binding site [nucleotide binding]; other site 1205677003099 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1205677003100 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205677003101 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1205677003102 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1205677003103 citrate synthase; Provisional; Region: PRK14033 1205677003104 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1205677003105 oxalacetate binding site [chemical binding]; other site 1205677003106 citrylCoA binding site [chemical binding]; other site 1205677003107 coenzyme A binding site [chemical binding]; other site 1205677003108 catalytic triad [active] 1205677003109 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1205677003110 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1205677003111 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1205677003112 THF binding site; other site 1205677003113 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1205677003114 substrate binding site [chemical binding]; other site 1205677003115 THF binding site; other site 1205677003116 zinc-binding site [ion binding]; other site 1205677003117 PPE family; Region: PPE; pfam00823 1205677003118 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677003119 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677003120 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677003121 substrate binding site [chemical binding]; other site 1205677003122 oxyanion hole (OAH) forming residues; other site 1205677003123 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1205677003124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1205677003125 CAAX protease self-immunity; Region: Abi; pfam02517 1205677003126 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205677003127 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677003128 substrate binding site [chemical binding]; other site 1205677003129 oxyanion hole (OAH) forming residues; other site 1205677003130 trimer interface [polypeptide binding]; other site 1205677003131 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205677003132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677003133 substrate binding site [chemical binding]; other site 1205677003134 oxyanion hole (OAH) forming residues; other site 1205677003135 trimer interface [polypeptide binding]; other site 1205677003136 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205677003137 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205677003138 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1205677003139 NAD binding site [chemical binding]; other site 1205677003140 homodimer interface [polypeptide binding]; other site 1205677003141 homotetramer interface [polypeptide binding]; other site 1205677003142 active site 1205677003143 MMPL family; Region: MMPL; pfam03176 1205677003144 MMPL family; Region: MMPL; pfam03176 1205677003145 Integrase core domain; Region: rve; pfam00665 1205677003146 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205677003147 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205677003148 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677003149 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677003150 active site 1205677003151 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1205677003152 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1205677003153 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1205677003154 NAD-dependent deacetylase; Provisional; Region: PRK00481 1205677003155 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1205677003156 NAD+ binding site [chemical binding]; other site 1205677003157 substrate binding site [chemical binding]; other site 1205677003158 Zn binding site [ion binding]; other site 1205677003159 Predicted transcriptional regulators [Transcription]; Region: COG1725 1205677003160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677003161 DNA-binding site [nucleotide binding]; DNA binding site 1205677003162 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677003163 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1205677003164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1205677003165 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205677003166 uncharacterized HhH-GPD family protein; Region: TIGR03252 1205677003167 minor groove reading motif; other site 1205677003168 helix-hairpin-helix signature motif; other site 1205677003169 mannosyltransferase; Provisional; Region: pimE; PRK13375 1205677003170 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205677003171 aromatic arch; other site 1205677003172 DCoH dimer interaction site [polypeptide binding]; other site 1205677003173 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205677003174 DCoH tetramer interaction site [polypeptide binding]; other site 1205677003175 substrate binding site [chemical binding]; other site 1205677003176 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1205677003177 active site 1205677003178 8-oxo-dGMP binding site [chemical binding]; other site 1205677003179 nudix motif; other site 1205677003180 metal binding site [ion binding]; metal-binding site 1205677003181 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1205677003182 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1205677003183 [4Fe-4S] binding site [ion binding]; other site 1205677003184 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677003185 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677003186 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677003187 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1205677003188 molybdopterin cofactor binding site; other site 1205677003189 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1205677003190 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1205677003191 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1205677003192 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1205677003193 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1205677003194 G1 box; other site 1205677003195 putative GEF interaction site [polypeptide binding]; other site 1205677003196 GTP/Mg2+ binding site [chemical binding]; other site 1205677003197 Switch I region; other site 1205677003198 G2 box; other site 1205677003199 G3 box; other site 1205677003200 Switch II region; other site 1205677003201 G4 box; other site 1205677003202 G5 box; other site 1205677003203 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1205677003204 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1205677003205 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205677003206 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1205677003207 PE family; Region: PE; pfam00934 1205677003208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677003209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677003210 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677003211 PPE family; Region: PPE; pfam00823 1205677003212 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677003213 PE family; Region: PE; pfam00934 1205677003214 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1205677003215 PE family; Region: PE; pfam00934 1205677003216 FO synthase; Reviewed; Region: fbiC; PRK09234 1205677003217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677003218 FeS/SAM binding site; other site 1205677003219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677003220 FeS/SAM binding site; other site 1205677003221 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1205677003222 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1205677003223 active site 1205677003224 FMN binding site [chemical binding]; other site 1205677003225 2,4-decadienoyl-CoA binding site; other site 1205677003226 catalytic residue [active] 1205677003227 4Fe-4S cluster binding site [ion binding]; other site 1205677003228 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1205677003229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677003230 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205677003231 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205677003232 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1205677003233 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1205677003234 4Fe-4S binding domain; Region: Fer4; pfam00037 1205677003235 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1205677003236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677003237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677003238 homodimer interface [polypeptide binding]; other site 1205677003239 catalytic residue [active] 1205677003240 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205677003241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677003242 ATP binding site [chemical binding]; other site 1205677003243 putative Mg++ binding site [ion binding]; other site 1205677003244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205677003245 ATP-binding site [chemical binding]; other site 1205677003246 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677003247 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677003248 active site 1205677003249 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677003250 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677003251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677003252 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205677003253 Enoylreductase; Region: PKS_ER; smart00829 1205677003254 NAD(P) binding site [chemical binding]; other site 1205677003255 KR domain; Region: KR; pfam08659 1205677003256 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205677003257 putative NADP binding site [chemical binding]; other site 1205677003258 active site 1205677003259 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677003260 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205677003261 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677003262 PE-PPE domain; Region: PE-PPE; pfam08237 1205677003263 acyl-CoA synthetase; Validated; Region: PRK05850 1205677003264 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677003265 acyl-activating enzyme (AAE) consensus motif; other site 1205677003266 active site 1205677003267 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205677003268 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205677003269 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1205677003270 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1205677003271 Glutamate binding site [chemical binding]; other site 1205677003272 NAD binding site [chemical binding]; other site 1205677003273 catalytic residues [active] 1205677003274 Proline dehydrogenase; Region: Pro_dh; cl03282 1205677003275 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1205677003276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677003277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677003278 DNA binding residues [nucleotide binding] 1205677003279 haloalkane dehalogenase; Provisional; Region: PRK03204 1205677003280 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205677003281 catalytic site [active] 1205677003282 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677003283 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1205677003284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205677003285 PGAP1-like protein; Region: PGAP1; pfam07819 1205677003286 acyl-CoA synthetase; Validated; Region: PRK07787 1205677003287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677003288 acyl-activating enzyme (AAE) consensus motif; other site 1205677003289 AMP binding site [chemical binding]; other site 1205677003290 active site 1205677003291 CoA binding site [chemical binding]; other site 1205677003292 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205677003293 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205677003294 PE family; Region: PE; pfam00934 1205677003295 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677003296 PPE family; Region: PPE; pfam00823 1205677003297 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677003298 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205677003299 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205677003300 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205677003301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677003302 putative substrate translocation pore; other site 1205677003303 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1205677003304 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1205677003305 putative trimer interface [polypeptide binding]; other site 1205677003306 putative CoA binding site [chemical binding]; other site 1205677003307 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1205677003308 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1205677003309 metal binding site [ion binding]; metal-binding site 1205677003310 putative dimer interface [polypeptide binding]; other site 1205677003311 Predicted ATPase [General function prediction only]; Region: COG3899 1205677003312 TIGR00730 family protein; Region: TIGR00730 1205677003313 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1205677003314 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1205677003315 acyl-activating enzyme (AAE) consensus motif; other site 1205677003316 putative AMP binding site [chemical binding]; other site 1205677003317 putative active site [active] 1205677003318 putative CoA binding site [chemical binding]; other site 1205677003319 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1205677003320 dihydropteroate synthase; Region: DHPS; TIGR01496 1205677003321 substrate binding pocket [chemical binding]; other site 1205677003322 dimer interface [polypeptide binding]; other site 1205677003323 inhibitor binding site; inhibition site 1205677003324 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1205677003325 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205677003326 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205677003327 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1205677003328 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1205677003329 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1205677003330 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205677003331 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1205677003332 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1205677003333 ligand binding site; other site 1205677003334 oligomer interface; other site 1205677003335 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1205677003336 dimer interface [polypeptide binding]; other site 1205677003337 N-terminal domain interface [polypeptide binding]; other site 1205677003338 sulfate 1 binding site; other site 1205677003339 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1205677003340 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677003341 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1205677003342 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1205677003343 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1205677003344 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205677003345 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205677003346 Walker A/P-loop; other site 1205677003347 ATP binding site [chemical binding]; other site 1205677003348 Q-loop/lid; other site 1205677003349 ABC transporter signature motif; other site 1205677003350 Walker B; other site 1205677003351 D-loop; other site 1205677003352 H-loop/switch region; other site 1205677003353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677003354 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205677003355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677003356 S-adenosylmethionine binding site [chemical binding]; other site 1205677003357 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1205677003358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677003359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677003360 DNA binding residues [nucleotide binding] 1205677003361 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1205677003362 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205677003363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205677003364 protein binding site [polypeptide binding]; other site 1205677003365 sec-independent translocase; Provisional; Region: PRK03100 1205677003366 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205677003367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677003368 active site 1205677003369 motif I; other site 1205677003370 motif II; other site 1205677003371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677003372 Predicted membrane protein [Function unknown]; Region: COG3428 1205677003373 Bacterial PH domain; Region: DUF304; pfam03703 1205677003374 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1205677003375 Domain of unknown function DUF59; Region: DUF59; cl00941 1205677003376 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1205677003377 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1205677003378 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1205677003379 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205677003380 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205677003381 catalytic residue [active] 1205677003382 Predicted membrane protein [Function unknown]; Region: COG4420 1205677003383 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1205677003384 MgtE intracellular N domain; Region: MgtE_N; smart00924 1205677003385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1205677003386 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1205677003387 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205677003388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205677003389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677003390 dimer interface [polypeptide binding]; other site 1205677003391 conserved gate region; other site 1205677003392 putative PBP binding loops; other site 1205677003393 ABC-ATPase subunit interface; other site 1205677003394 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205677003395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677003396 dimer interface [polypeptide binding]; other site 1205677003397 conserved gate region; other site 1205677003398 ABC-ATPase subunit interface; other site 1205677003399 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205677003400 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205677003401 Walker A/P-loop; other site 1205677003402 ATP binding site [chemical binding]; other site 1205677003403 Q-loop/lid; other site 1205677003404 ABC transporter signature motif; other site 1205677003405 Walker B; other site 1205677003406 D-loop; other site 1205677003407 H-loop/switch region; other site 1205677003408 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1205677003409 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1205677003410 oligomer interface [polypeptide binding]; other site 1205677003411 metal binding site [ion binding]; metal-binding site 1205677003412 metal binding site [ion binding]; metal-binding site 1205677003413 putative Cl binding site [ion binding]; other site 1205677003414 basic sphincter; other site 1205677003415 hydrophobic gate; other site 1205677003416 periplasmic entrance; other site 1205677003417 malate dehydrogenase; Provisional; Region: PRK05442 1205677003418 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1205677003419 NAD(P) binding site [chemical binding]; other site 1205677003420 dimer interface [polypeptide binding]; other site 1205677003421 malate binding site [chemical binding]; other site 1205677003422 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205677003423 PE family; Region: PE; pfam00934 1205677003424 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1205677003425 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1205677003426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677003427 NAD(P) binding site [chemical binding]; other site 1205677003428 active site 1205677003429 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205677003430 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205677003431 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1205677003432 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205677003433 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 1205677003434 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1205677003435 TPP-binding site [chemical binding]; other site 1205677003436 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1205677003437 dimer interface [polypeptide binding]; other site 1205677003438 PYR/PP interface [polypeptide binding]; other site 1205677003439 TPP binding site [chemical binding]; other site 1205677003440 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205677003441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677003442 putative substrate translocation pore; other site 1205677003443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677003444 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1205677003445 RNase_H superfamily; Region: RNase_H_2; pfam13482 1205677003446 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1205677003447 Part of AAA domain; Region: AAA_19; pfam13245 1205677003448 AAA domain; Region: AAA_12; pfam13087 1205677003449 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205677003450 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1205677003451 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205677003452 ATP binding site [chemical binding]; other site 1205677003453 Mg++ binding site [ion binding]; other site 1205677003454 motif III; other site 1205677003455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677003456 nucleotide binding region [chemical binding]; other site 1205677003457 ATP-binding site [chemical binding]; other site 1205677003458 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1205677003459 putative RNA binding site [nucleotide binding]; other site 1205677003460 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1205677003461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677003462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677003463 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677003464 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677003465 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677003466 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205677003467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677003468 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205677003469 putative substrate translocation pore; other site 1205677003470 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1205677003471 Fe-S cluster binding site [ion binding]; other site 1205677003472 DNA binding site [nucleotide binding] 1205677003473 active site 1205677003474 hypothetical protein; Validated; Region: PRK05868 1205677003475 hypothetical protein; Provisional; Region: PRK07236 1205677003476 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205677003477 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205677003478 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1205677003479 HIT family signature motif; other site 1205677003480 catalytic residue [active] 1205677003481 amidase; Provisional; Region: PRK12470 1205677003482 Amidase; Region: Amidase; pfam01425 1205677003483 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677003484 cyclase homology domain; Region: CHD; cd07302 1205677003485 nucleotidyl binding site; other site 1205677003486 metal binding site [ion binding]; metal-binding site 1205677003487 dimer interface [polypeptide binding]; other site 1205677003488 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677003489 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677003490 active site 1205677003491 ATP binding site [chemical binding]; other site 1205677003492 substrate binding site [chemical binding]; other site 1205677003493 activation loop (A-loop); other site 1205677003494 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677003495 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677003496 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677003497 phosphopeptide binding site; other site 1205677003498 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677003499 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677003500 phosphopeptide binding site; other site 1205677003501 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1205677003502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205677003503 Walker A/P-loop; other site 1205677003504 ATP binding site [chemical binding]; other site 1205677003505 Q-loop/lid; other site 1205677003506 ABC transporter signature motif; other site 1205677003507 Walker B; other site 1205677003508 D-loop; other site 1205677003509 H-loop/switch region; other site 1205677003510 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1205677003511 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205677003512 Evidence 2b : Function of strongly homologous gene; PubMedId : 15043876, 16585755; Product type e : enzyme 1205677003513 Evidence 2b : Function of strongly homologous gene; PubMedId : 15043876, 16585755; Product type e : enzyme 1205677003514 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205677003515 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205677003516 DNA binding site [nucleotide binding] 1205677003517 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677003518 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677003519 phosphopeptide binding site; other site 1205677003520 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1205677003521 putative active site [active] 1205677003522 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1205677003523 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205677003524 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677003525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205677003526 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1205677003527 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205677003528 Walker A/P-loop; other site 1205677003529 ATP binding site [chemical binding]; other site 1205677003530 Q-loop/lid; other site 1205677003531 ABC transporter signature motif; other site 1205677003532 Walker B; other site 1205677003533 D-loop; other site 1205677003534 H-loop/switch region; other site 1205677003535 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205677003536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205677003537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677003538 Walker A/P-loop; other site 1205677003539 ATP binding site [chemical binding]; other site 1205677003540 Q-loop/lid; other site 1205677003541 ABC transporter signature motif; other site 1205677003542 Walker B; other site 1205677003543 D-loop; other site 1205677003544 H-loop/switch region; other site 1205677003545 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205677003546 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205677003547 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677003548 catalytic core [active] 1205677003549 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1205677003550 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1205677003551 active site 1205677003552 metal binding site [ion binding]; metal-binding site 1205677003553 DNA binding site [nucleotide binding] 1205677003554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677003555 Walker A/P-loop; other site 1205677003556 ATP binding site [chemical binding]; other site 1205677003557 choline dehydrogenase; Validated; Region: PRK02106 1205677003558 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205677003559 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205677003560 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205677003561 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1205677003562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205677003563 Walker A/P-loop; other site 1205677003564 ATP binding site [chemical binding]; other site 1205677003565 Q-loop/lid; other site 1205677003566 ABC transporter signature motif; other site 1205677003567 Walker B; other site 1205677003568 D-loop; other site 1205677003569 H-loop/switch region; other site 1205677003570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205677003571 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205677003572 Walker A/P-loop; other site 1205677003573 ATP binding site [chemical binding]; other site 1205677003574 Q-loop/lid; other site 1205677003575 ABC transporter signature motif; other site 1205677003576 Walker B; other site 1205677003577 D-loop; other site 1205677003578 H-loop/switch region; other site 1205677003579 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1205677003580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205677003581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677003582 dimer interface [polypeptide binding]; other site 1205677003583 conserved gate region; other site 1205677003584 putative PBP binding loops; other site 1205677003585 ABC-ATPase subunit interface; other site 1205677003586 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1205677003587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677003588 dimer interface [polypeptide binding]; other site 1205677003589 conserved gate region; other site 1205677003590 putative PBP binding loops; other site 1205677003591 ABC-ATPase subunit interface; other site 1205677003592 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1205677003593 active site clefts [active] 1205677003594 zinc binding site [ion binding]; other site 1205677003595 dimer interface [polypeptide binding]; other site 1205677003596 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1205677003597 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1205677003598 Active Sites [active] 1205677003599 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1205677003600 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1205677003601 CysD dimerization site [polypeptide binding]; other site 1205677003602 G1 box; other site 1205677003603 putative GEF interaction site [polypeptide binding]; other site 1205677003604 GTP/Mg2+ binding site [chemical binding]; other site 1205677003605 Switch I region; other site 1205677003606 G2 box; other site 1205677003607 G3 box; other site 1205677003608 Switch II region; other site 1205677003609 G4 box; other site 1205677003610 G5 box; other site 1205677003611 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1205677003612 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1205677003613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677003614 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1205677003615 Walker A/P-loop; other site 1205677003616 ligand-binding site [chemical binding]; other site 1205677003617 ATP binding site [chemical binding]; other site 1205677003618 Rrf2 family protein; Region: rrf2_super; TIGR00738 1205677003619 Transcriptional regulator; Region: Rrf2; pfam02082 1205677003620 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205677003621 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1205677003622 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205677003623 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205677003624 Putative esterase; Region: Esterase; pfam00756 1205677003625 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1205677003626 Predicted membrane protein [Function unknown]; Region: COG4325 1205677003627 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1205677003628 Evidence 4 : Homologs of previously reported genes of unknown function 1205677003629 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677003630 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1205677003631 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1205677003632 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1205677003633 active site 1205677003634 HIGH motif; other site 1205677003635 KMSK motif region; other site 1205677003636 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1205677003637 tRNA binding surface [nucleotide binding]; other site 1205677003638 anticodon binding site; other site 1205677003639 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1205677003640 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1205677003641 active site 1205677003642 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205677003643 substrate binding site [chemical binding]; other site 1205677003644 catalytic residues [active] 1205677003645 dimer interface [polypeptide binding]; other site 1205677003646 homoserine dehydrogenase; Provisional; Region: PRK06349 1205677003647 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1205677003648 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1205677003649 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1205677003650 threonine synthase; Reviewed; Region: PRK06721 1205677003651 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1205677003652 homodimer interface [polypeptide binding]; other site 1205677003653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677003654 catalytic residue [active] 1205677003655 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1205677003656 Integrase core domain; Region: rve; pfam00665 1205677003657 transcription termination factor Rho; Provisional; Region: PRK12678 1205677003658 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1205677003659 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205677003660 RNA binding site [nucleotide binding]; other site 1205677003661 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1205677003662 multimer interface [polypeptide binding]; other site 1205677003663 Walker A motif; other site 1205677003664 ATP binding site [chemical binding]; other site 1205677003665 Walker B motif; other site 1205677003666 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1205677003667 peptide chain release factor 1; Region: prfA; TIGR00019 1205677003668 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205677003669 RF-1 domain; Region: RF-1; pfam00472 1205677003670 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1205677003671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677003672 S-adenosylmethionine binding site [chemical binding]; other site 1205677003673 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1205677003674 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1205677003675 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1205677003676 Mg++ binding site [ion binding]; other site 1205677003677 putative catalytic motif [active] 1205677003678 substrate binding site [chemical binding]; other site 1205677003679 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1205677003680 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1205677003681 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1205677003682 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1205677003683 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1205677003684 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1205677003685 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1205677003686 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1205677003687 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1205677003688 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205677003689 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205677003690 Walker A motif; other site 1205677003691 ATP binding site [chemical binding]; other site 1205677003692 Walker B motif; other site 1205677003693 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205677003694 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1205677003695 core domain interface [polypeptide binding]; other site 1205677003696 delta subunit interface [polypeptide binding]; other site 1205677003697 epsilon subunit interface [polypeptide binding]; other site 1205677003698 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1205677003699 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205677003700 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1205677003701 alpha subunit interaction interface [polypeptide binding]; other site 1205677003702 Walker A motif; other site 1205677003703 ATP binding site [chemical binding]; other site 1205677003704 Walker B motif; other site 1205677003705 inhibitor binding site; inhibition site 1205677003706 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205677003707 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1205677003708 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1205677003709 gamma subunit interface [polypeptide binding]; other site 1205677003710 epsilon subunit interface [polypeptide binding]; other site 1205677003711 LBP interface [polypeptide binding]; other site 1205677003712 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1205677003713 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1205677003714 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1205677003715 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1205677003716 hinge; other site 1205677003717 active site 1205677003718 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1205677003719 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1205677003720 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205677003721 DNA binding site [nucleotide binding] 1205677003722 active site 1205677003723 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1205677003724 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1205677003725 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1205677003726 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1205677003727 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205677003728 minor groove reading motif; other site 1205677003729 helix-hairpin-helix signature motif; other site 1205677003730 substrate binding pocket [chemical binding]; other site 1205677003731 active site 1205677003732 HAMP domain; Region: HAMP; pfam00672 1205677003733 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677003734 cyclase homology domain; Region: CHD; cd07302 1205677003735 nucleotidyl binding site; other site 1205677003736 metal binding site [ion binding]; metal-binding site 1205677003737 dimer interface [polypeptide binding]; other site 1205677003738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677003739 dimerization interface [polypeptide binding]; other site 1205677003740 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677003741 cyclase homology domain; Region: CHD; cd07302 1205677003742 nucleotidyl binding site; other site 1205677003743 metal binding site [ion binding]; metal-binding site 1205677003744 dimer interface [polypeptide binding]; other site 1205677003745 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1205677003746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677003747 dimerization interface [polypeptide binding]; other site 1205677003748 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677003749 cyclase homology domain; Region: CHD; cd07302 1205677003750 nucleotidyl binding site; other site 1205677003751 metal binding site [ion binding]; metal-binding site 1205677003752 dimer interface [polypeptide binding]; other site 1205677003753 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1205677003754 hypothetical protein; Provisional; Region: PRK03298 1205677003755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677003756 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1205677003757 dimer interface [polypeptide binding]; other site 1205677003758 substrate binding site [chemical binding]; other site 1205677003759 metal binding site [ion binding]; metal-binding site 1205677003760 putative acyltransferase; Provisional; Region: PRK05790 1205677003761 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205677003762 dimer interface [polypeptide binding]; other site 1205677003763 active site 1205677003764 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1205677003765 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1205677003766 PE family; Region: PE; pfam00934 1205677003767 glycogen branching enzyme; Provisional; Region: PRK05402 1205677003768 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1205677003769 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1205677003770 active site 1205677003771 catalytic site [active] 1205677003772 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1205677003773 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1205677003774 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1205677003775 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1205677003776 active site 1205677003777 homodimer interface [polypeptide binding]; other site 1205677003778 catalytic site [active] 1205677003779 acceptor binding site [chemical binding]; other site 1205677003780 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1205677003781 putative homodimer interface [polypeptide binding]; other site 1205677003782 putative active site pocket [active] 1205677003783 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1205677003784 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1205677003785 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1205677003786 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1205677003787 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1205677003788 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1205677003789 active site 1205677003790 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1205677003791 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1205677003792 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1205677003793 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1205677003794 cleavage site 1205677003795 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1205677003796 MPN+ (JAMM) motif; other site 1205677003797 Zinc-binding site [ion binding]; other site 1205677003798 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205677003799 MoaE interaction surface [polypeptide binding]; other site 1205677003800 MoeB interaction surface [polypeptide binding]; other site 1205677003801 thiocarboxylated glycine; other site 1205677003802 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205677003803 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205677003804 dimer interface [polypeptide binding]; other site 1205677003805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677003806 catalytic residue [active] 1205677003807 Rhomboid family; Region: Rhomboid; pfam01694 1205677003808 glutamate racemase; Provisional; Region: PRK00865 1205677003809 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205677003810 ribonuclease PH; Reviewed; Region: rph; PRK00173 1205677003811 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1205677003812 hexamer interface [polypeptide binding]; other site 1205677003813 active site 1205677003814 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1205677003815 active site 1205677003816 dimerization interface [polypeptide binding]; other site 1205677003817 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1205677003818 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1205677003819 acyl carrier protein; Validated; Region: PRK05883 1205677003820 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1205677003821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677003822 acyl-activating enzyme (AAE) consensus motif; other site 1205677003823 AMP binding site [chemical binding]; other site 1205677003824 active site 1205677003825 CoA binding site [chemical binding]; other site 1205677003826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677003827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677003828 active site 1205677003829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1205677003830 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1205677003831 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205677003832 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205677003833 FAD binding pocket [chemical binding]; other site 1205677003834 FAD binding motif [chemical binding]; other site 1205677003835 phosphate binding motif [ion binding]; other site 1205677003836 NAD binding pocket [chemical binding]; other site 1205677003837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677003838 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205677003839 Walker A/P-loop; other site 1205677003840 ATP binding site [chemical binding]; other site 1205677003841 Q-loop/lid; other site 1205677003842 ABC transporter signature motif; other site 1205677003843 Walker B; other site 1205677003844 D-loop; other site 1205677003845 H-loop/switch region; other site 1205677003846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677003847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205677003848 Walker A/P-loop; other site 1205677003849 ATP binding site [chemical binding]; other site 1205677003850 Q-loop/lid; other site 1205677003851 ABC transporter signature motif; other site 1205677003852 Walker B; other site 1205677003853 D-loop; other site 1205677003854 H-loop/switch region; other site 1205677003855 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205677003856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677003857 NAD(P) binding site [chemical binding]; other site 1205677003858 active site 1205677003859 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1205677003860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677003861 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205677003862 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205677003863 GAF domain; Region: GAF; pfam01590 1205677003864 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1205677003865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1205677003866 metal binding site [ion binding]; metal-binding site 1205677003867 active site 1205677003868 I-site; other site 1205677003869 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205677003870 hypothetical protein; Provisional; Region: PRK07877 1205677003871 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1205677003872 ATP binding site [chemical binding]; other site 1205677003873 substrate interface [chemical binding]; other site 1205677003874 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205677003875 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205677003876 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677003877 cyclase homology domain; Region: CHD; cd07302 1205677003878 nucleotidyl binding site; other site 1205677003879 dimer interface [polypeptide binding]; other site 1205677003880 metal binding site [ion binding]; metal-binding site 1205677003881 AAA ATPase domain; Region: AAA_16; pfam13191 1205677003882 Predicted ATPase [General function prediction only]; Region: COG3903 1205677003883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677003884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677003885 DNA binding residues [nucleotide binding] 1205677003886 dimerization interface [polypeptide binding]; other site 1205677003887 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677003888 cyclase homology domain; Region: CHD; cd07302 1205677003889 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205677003890 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205677003891 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677003892 PPE family; Region: PPE; pfam00823 1205677003893 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677003894 PAS fold; Region: PAS_4; pfam08448 1205677003895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205677003896 putative active site [active] 1205677003897 heme pocket [chemical binding]; other site 1205677003898 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205677003899 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1205677003900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1205677003901 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205677003902 anti sigma factor interaction site; other site 1205677003903 regulatory phosphorylation site [posttranslational modification]; other site 1205677003904 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205677003905 anti sigma factor interaction site; other site 1205677003906 regulatory phosphorylation site [posttranslational modification]; other site 1205677003907 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205677003908 synthetase active site [active] 1205677003909 NTP binding site [chemical binding]; other site 1205677003910 metal binding site [ion binding]; metal-binding site 1205677003911 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677003912 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677003913 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205677003914 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1205677003915 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205677003916 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205677003917 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205677003918 malonyl-CoA binding site [chemical binding]; other site 1205677003919 dimer interface [polypeptide binding]; other site 1205677003920 active site 1205677003921 product binding site; other site 1205677003922 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205677003923 uncharacterized domain; Region: TIGR00702 1205677003924 YcaO-like family; Region: YcaO; pfam02624 1205677003925 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1205677003926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677003927 S-adenosylmethionine binding site [chemical binding]; other site 1205677003928 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677003929 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1205677003930 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1205677003931 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1205677003932 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205677003933 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205677003934 dihydroorotase; Validated; Region: pyrC; PRK09357 1205677003935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205677003936 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1205677003937 active site 1205677003938 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1205677003939 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1205677003940 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1205677003941 catalytic site [active] 1205677003942 subunit interface [polypeptide binding]; other site 1205677003943 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1205677003944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205677003945 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205677003946 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1205677003947 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205677003948 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205677003949 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1205677003950 IMP binding site; other site 1205677003951 dimer interface [polypeptide binding]; other site 1205677003952 interdomain contacts; other site 1205677003953 partial ornithine binding site; other site 1205677003954 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1205677003955 active site 1205677003956 dimer interface [polypeptide binding]; other site 1205677003957 PE family; Region: PE; pfam00934 1205677003958 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677003959 PPE family; Region: PPE; pfam00823 1205677003960 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1205677003961 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1205677003962 catalytic site [active] 1205677003963 G-X2-G-X-G-K; other site 1205677003964 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1205677003965 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1205677003966 Flavoprotein; Region: Flavoprotein; pfam02441 1205677003967 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1205677003968 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1205677003969 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1205677003970 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1205677003971 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1205677003972 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205677003973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205677003974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677003975 Cytochrome P450; Region: p450; cl12078 1205677003976 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205677003977 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205677003978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205677003979 PE family; Region: PE; pfam00934 1205677003980 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205677003981 oligomeric interface; other site 1205677003982 putative active site [active] 1205677003983 homodimer interface [polypeptide binding]; other site 1205677003984 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677003985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677003986 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677003987 substrate binding pocket [chemical binding]; other site 1205677003988 Predicted membrane protein [Function unknown]; Region: COG3714 1205677003989 primosome assembly protein PriA; Provisional; Region: PRK14873 1205677003990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677003991 S-adenosylmethionine binding site [chemical binding]; other site 1205677003992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205677003993 MarR family; Region: MarR; pfam01047 1205677003994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677003995 S-adenosylmethionine binding site [chemical binding]; other site 1205677003996 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1205677003997 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1205677003998 putative active site [active] 1205677003999 substrate binding site [chemical binding]; other site 1205677004000 putative cosubstrate binding site; other site 1205677004001 catalytic site [active] 1205677004002 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1205677004003 substrate binding site [chemical binding]; other site 1205677004004 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1205677004005 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1205677004006 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1205677004007 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1205677004008 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1205677004009 substrate binding site [chemical binding]; other site 1205677004010 hexamer interface [polypeptide binding]; other site 1205677004011 metal binding site [ion binding]; metal-binding site 1205677004012 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1205677004013 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1205677004014 catalytic motif [active] 1205677004015 Zn binding site [ion binding]; other site 1205677004016 RibD C-terminal domain; Region: RibD_C; pfam01872 1205677004017 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205677004018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677004019 putative substrate translocation pore; other site 1205677004020 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205677004021 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1205677004022 Lumazine binding domain; Region: Lum_binding; pfam00677 1205677004023 Lumazine binding domain; Region: Lum_binding; pfam00677 1205677004024 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205677004025 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1205677004026 dimer interface [polypeptide binding]; other site 1205677004027 active site 1205677004028 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205677004029 substrate binding site [chemical binding]; other site 1205677004030 catalytic residue [active] 1205677004031 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1205677004032 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1205677004033 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1205677004034 dimerization interface [polypeptide binding]; other site 1205677004035 active site 1205677004036 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1205677004037 homopentamer interface [polypeptide binding]; other site 1205677004038 active site 1205677004039 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205677004040 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677004041 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1205677004042 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1205677004043 putative sugar binding sites [chemical binding]; other site 1205677004044 Q-X-W motif; other site 1205677004045 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1205677004046 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205677004047 GIY-YIG motif/motif A; other site 1205677004048 active site 1205677004049 catalytic site [active] 1205677004050 putative DNA binding site [nucleotide binding]; other site 1205677004051 metal binding site [ion binding]; metal-binding site 1205677004052 UvrB/uvrC motif; Region: UVR; pfam02151 1205677004053 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1205677004054 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205677004055 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1205677004056 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1205677004057 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1205677004058 phosphate binding site [ion binding]; other site 1205677004059 putative substrate binding pocket [chemical binding]; other site 1205677004060 dimer interface [polypeptide binding]; other site 1205677004061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1205677004062 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1205677004063 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677004064 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677004065 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677004066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677004067 acyl-CoA synthetase; Provisional; Region: PRK13382 1205677004068 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205677004069 acyl-activating enzyme (AAE) consensus motif; other site 1205677004070 putative AMP binding site [chemical binding]; other site 1205677004071 putative active site [active] 1205677004072 putative CoA binding site [chemical binding]; other site 1205677004073 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677004074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205677004075 putative acyl-acceptor binding pocket; other site 1205677004076 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205677004077 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205677004078 PE family; Region: PE; pfam00934 1205677004079 PE-PPE domain; Region: PE-PPE; pfam08237 1205677004080 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1205677004081 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205677004082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677004083 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205677004084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205677004085 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205677004086 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1205677004087 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1205677004088 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1205677004089 Phosphoglycerate kinase; Region: PGK; pfam00162 1205677004090 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1205677004091 substrate binding site [chemical binding]; other site 1205677004092 hinge regions; other site 1205677004093 ADP binding site [chemical binding]; other site 1205677004094 catalytic site [active] 1205677004095 triosephosphate isomerase; Provisional; Region: PRK14567 1205677004096 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1205677004097 substrate binding site [chemical binding]; other site 1205677004098 dimer interface [polypeptide binding]; other site 1205677004099 catalytic triad [active] 1205677004100 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205677004101 Preprotein translocase SecG subunit; Region: SecG; cl09123 1205677004102 PE family; Region: PE; pfam00934 1205677004103 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1205677004104 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1205677004105 molybdopterin cofactor binding site [chemical binding]; other site 1205677004106 substrate binding site [chemical binding]; other site 1205677004107 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1205677004108 molybdopterin cofactor binding site; other site 1205677004109 hydrophobic ligand binding site; other site 1205677004110 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1205677004111 Filoviridae VP35; Region: Filo_VP35; pfam02097 1205677004112 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1205677004113 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1205677004114 putative active site [active] 1205677004115 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1205677004116 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1205677004117 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1205677004118 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205677004119 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205677004120 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1205677004121 putative active site [active] 1205677004122 transaldolase; Provisional; Region: PRK03903 1205677004123 catalytic residue [active] 1205677004124 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1205677004125 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1205677004126 TPP-binding site [chemical binding]; other site 1205677004127 dimer interface [polypeptide binding]; other site 1205677004128 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205677004129 PYR/PP interface [polypeptide binding]; other site 1205677004130 dimer interface [polypeptide binding]; other site 1205677004131 TPP binding site [chemical binding]; other site 1205677004132 PE family; Region: PE; pfam00934 1205677004133 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1205677004134 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677004135 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1205677004136 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205677004137 Evidence 5 : No homology to any previously reported sequences 1205677004138 Evidence 4 : Homologs of previously reported genes of unknown function 1205677004139 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205677004140 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205677004141 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1205677004142 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1205677004143 NADP binding site [chemical binding]; other site 1205677004144 dimer interface [polypeptide binding]; other site 1205677004145 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1205677004146 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1205677004147 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205677004148 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205677004149 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205677004150 Walker A/P-loop; other site 1205677004151 ATP binding site [chemical binding]; other site 1205677004152 Q-loop/lid; other site 1205677004153 ABC transporter signature motif; other site 1205677004154 Walker B; other site 1205677004155 D-loop; other site 1205677004156 H-loop/switch region; other site 1205677004157 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1205677004158 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205677004159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677004160 putative DNA binding site [nucleotide binding]; other site 1205677004161 putative Zn2+ binding site [ion binding]; other site 1205677004162 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1205677004163 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205677004164 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205677004165 protein-splicing catalytic site; other site 1205677004166 thioester formation/cholesterol transfer; other site 1205677004167 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1205677004168 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205677004169 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205677004170 protein-splicing catalytic site; other site 1205677004171 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1205677004172 FeS assembly protein SufD; Region: sufD; TIGR01981 1205677004173 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1205677004174 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1205677004175 Walker A/P-loop; other site 1205677004176 ATP binding site [chemical binding]; other site 1205677004177 Q-loop/lid; other site 1205677004178 ABC transporter signature motif; other site 1205677004179 Walker B; other site 1205677004180 D-loop; other site 1205677004181 H-loop/switch region; other site 1205677004182 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205677004183 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1205677004184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677004185 catalytic residue [active] 1205677004186 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1205677004187 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1205677004188 trimerization site [polypeptide binding]; other site 1205677004189 active site 1205677004190 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1205677004191 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1205677004192 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1205677004193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677004194 active site 1205677004195 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1205677004196 PE family; Region: PE; pfam00934 1205677004197 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1205677004198 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677004199 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205677004200 catalytic residues [active] 1205677004201 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205677004202 catalytic residues [active] 1205677004203 enoyl-CoA hydratase; Provisional; Region: PRK05864 1205677004204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677004205 substrate binding site [chemical binding]; other site 1205677004206 oxyanion hole (OAH) forming residues; other site 1205677004207 trimer interface [polypeptide binding]; other site 1205677004208 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205677004209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677004210 Walker A/P-loop; other site 1205677004211 ATP binding site [chemical binding]; other site 1205677004212 Q-loop/lid; other site 1205677004213 ABC transporter signature motif; other site 1205677004214 Walker B; other site 1205677004215 D-loop; other site 1205677004216 H-loop/switch region; other site 1205677004217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205677004218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677004219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677004220 aconitate hydratase; Validated; Region: PRK09277 1205677004221 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1205677004222 substrate binding site [chemical binding]; other site 1205677004223 ligand binding site [chemical binding]; other site 1205677004224 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1205677004225 substrate binding site [chemical binding]; other site 1205677004226 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205677004227 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205677004228 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205677004229 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205677004230 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205677004231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677004232 Walker A motif; other site 1205677004233 ATP binding site [chemical binding]; other site 1205677004234 Walker B motif; other site 1205677004235 arginine finger; other site 1205677004236 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205677004237 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205677004238 hypothetical protein; Provisional; Region: PRK13685 1205677004239 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1205677004240 metal ion-dependent adhesion site (MIDAS); other site 1205677004241 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205677004242 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1205677004243 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1205677004244 NAD(P) binding site [chemical binding]; other site 1205677004245 homotetramer interface [polypeptide binding]; other site 1205677004246 homodimer interface [polypeptide binding]; other site 1205677004247 active site 1205677004248 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1205677004249 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1205677004250 NAD binding site [chemical binding]; other site 1205677004251 homotetramer interface [polypeptide binding]; other site 1205677004252 homodimer interface [polypeptide binding]; other site 1205677004253 substrate binding site [chemical binding]; other site 1205677004254 active site 1205677004255 ferrochelatase; Reviewed; Region: hemH; PRK00035 1205677004256 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1205677004257 C-terminal domain interface [polypeptide binding]; other site 1205677004258 active site 1205677004259 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1205677004260 active site 1205677004261 N-terminal domain interface [polypeptide binding]; other site 1205677004262 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1205677004263 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205677004264 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1205677004265 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1205677004266 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205677004267 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205677004268 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1205677004269 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1205677004270 heterodimer interface [polypeptide binding]; other site 1205677004271 substrate interaction site [chemical binding]; other site 1205677004272 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1205677004273 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1205677004274 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1205677004275 active site 1205677004276 substrate binding site [chemical binding]; other site 1205677004277 coenzyme B12 binding site [chemical binding]; other site 1205677004278 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1205677004279 B12 binding site [chemical binding]; other site 1205677004280 cobalt ligand [ion binding]; other site 1205677004281 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205677004282 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1205677004283 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1205677004284 Walker A; other site 1205677004285 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677004286 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677004287 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677004288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677004289 S-adenosylmethionine binding site [chemical binding]; other site 1205677004290 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1205677004291 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1205677004292 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1205677004293 Ligand binding site; other site 1205677004294 Putative Catalytic site; other site 1205677004295 DXD motif; other site 1205677004296 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1205677004297 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1205677004298 active site 1205677004299 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1205677004300 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205677004301 inhibitor-cofactor binding pocket; inhibition site 1205677004302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677004303 catalytic residue [active] 1205677004304 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1205677004305 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1205677004306 putative trimer interface [polypeptide binding]; other site 1205677004307 putative CoA binding site [chemical binding]; other site 1205677004308 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1205677004309 S-adenosylmethionine binding site [chemical binding]; other site 1205677004310 WbqC-like protein family; Region: WbqC; pfam08889 1205677004311 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1205677004312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677004313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677004314 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205677004315 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1205677004316 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1205677004317 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1205677004318 NADP-binding site; other site 1205677004319 homotetramer interface [polypeptide binding]; other site 1205677004320 substrate binding site [chemical binding]; other site 1205677004321 homodimer interface [polypeptide binding]; other site 1205677004322 active site 1205677004323 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1205677004324 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1205677004325 NADP binding site [chemical binding]; other site 1205677004326 active site 1205677004327 putative substrate binding site [chemical binding]; other site 1205677004328 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205677004329 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1205677004330 metal-binding site 1205677004331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677004332 S-adenosylmethionine binding site [chemical binding]; other site 1205677004333 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205677004334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205677004335 active site 1205677004336 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205677004337 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205677004338 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1205677004339 active site 1205677004340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205677004341 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205677004342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205677004343 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205677004344 active site 1205677004345 acyl-CoA synthetase; Validated; Region: PRK05850 1205677004346 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677004347 acyl-activating enzyme (AAE) consensus motif; other site 1205677004348 active site 1205677004349 Transport protein; Region: actII; TIGR00833 1205677004350 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205677004351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677004352 S-adenosylmethionine binding site [chemical binding]; other site 1205677004353 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205677004354 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205677004355 homodimer interface [polypeptide binding]; other site 1205677004356 active site 1205677004357 TDP-binding site; other site 1205677004358 acceptor substrate-binding pocket; other site 1205677004359 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205677004360 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205677004361 Probable Catalytic site; other site 1205677004362 metal-binding site 1205677004363 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205677004364 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205677004365 homodimer interface [polypeptide binding]; other site 1205677004366 active site 1205677004367 TDP-binding site; other site 1205677004368 acceptor substrate-binding pocket; other site 1205677004369 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680, 16573683; Product type pe : putative enzyme 1205677004370 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680, 16573683; Product type pe : putative enzyme 1205677004371 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12368446, 12657046, 16573683 1205677004372 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12368446, 12657046, 16573683 1205677004373 acyl-CoA synthetase; Validated; Region: PRK05850 1205677004374 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677004375 acyl-activating enzyme (AAE) consensus motif; other site 1205677004376 active site 1205677004377 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205677004378 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205677004379 NAD(P) binding site [chemical binding]; other site 1205677004380 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205677004381 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205677004382 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205677004383 CoenzymeA binding site [chemical binding]; other site 1205677004384 subunit interaction site [polypeptide binding]; other site 1205677004385 PHB binding site; other site 1205677004386 Nitronate monooxygenase; Region: NMO; pfam03060 1205677004387 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205677004388 FMN binding site [chemical binding]; other site 1205677004389 substrate binding site [chemical binding]; other site 1205677004390 putative catalytic residue [active] 1205677004391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677004392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677004393 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1205677004394 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205677004395 HIGH motif; other site 1205677004396 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205677004397 active site 1205677004398 KMSKS motif; other site 1205677004399 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1205677004400 tRNA binding surface [nucleotide binding]; other site 1205677004401 anticodon binding site; other site 1205677004402 DNA polymerase IV; Provisional; Region: PRK03348 1205677004403 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1205677004404 active site 1205677004405 DNA binding site [nucleotide binding] 1205677004406 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1205677004407 active site 1205677004408 homodimer interface [polypeptide binding]; other site 1205677004409 homotetramer interface [polypeptide binding]; other site 1205677004410 lipoprotein signal peptidase; Provisional; Region: PRK14764 1205677004411 lipoprotein signal peptidase; Provisional; Region: PRK14787 1205677004412 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1205677004413 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1205677004414 active site 1205677004415 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1205677004416 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1205677004417 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1205677004418 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1205677004419 apolar tunnel; other site 1205677004420 heme binding site [chemical binding]; other site 1205677004421 dimerization interface [polypeptide binding]; other site 1205677004422 short chain dehydrogenase; Provisional; Region: PRK05866 1205677004423 classical (c) SDRs; Region: SDR_c; cd05233 1205677004424 NAD(P) binding site [chemical binding]; other site 1205677004425 active site 1205677004426 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205677004427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677004428 NAD(P) binding site [chemical binding]; other site 1205677004429 active site 1205677004430 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205677004431 hydrophobic ligand binding site; other site 1205677004432 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1205677004433 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1205677004434 active site 1205677004435 PHP Thumb interface [polypeptide binding]; other site 1205677004436 metal binding site [ion binding]; metal-binding site 1205677004437 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1205677004438 generic binding surface II; other site 1205677004439 generic binding surface I; other site 1205677004440 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677004441 PPE family; Region: PPE; pfam00823 1205677004442 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677004443 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677004444 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205677004445 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205677004446 acyl-activating enzyme (AAE) consensus motif; other site 1205677004447 putative AMP binding site [chemical binding]; other site 1205677004448 putative active site [active] 1205677004449 putative CoA binding site [chemical binding]; other site 1205677004450 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1205677004451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1205677004452 putative acyl-acceptor binding pocket; other site 1205677004453 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1205677004454 L-aspartate oxidase; Provisional; Region: PRK06175 1205677004455 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205677004456 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1205677004457 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1205677004458 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1205677004459 Iron-sulfur protein interface; other site 1205677004460 proximal heme binding site [chemical binding]; other site 1205677004461 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1205677004462 Iron-sulfur protein interface; other site 1205677004463 proximal quinone binding site [chemical binding]; other site 1205677004464 C-subunit interface; other site 1205677004465 distal quinone binding site; other site 1205677004466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677004467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677004468 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205677004469 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677004470 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205677004471 threonine dehydratase; Validated; Region: PRK08639 1205677004472 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1205677004473 tetramer interface [polypeptide binding]; other site 1205677004474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677004475 catalytic residue [active] 1205677004476 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1205677004477 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205677004478 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677004479 putative active site [active] 1205677004480 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1205677004481 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1205677004482 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1205677004483 catalytic site [active] 1205677004484 active site 1205677004485 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1205677004486 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1205677004487 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1205677004488 active site 1205677004489 catalytic site [active] 1205677004490 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1205677004491 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1205677004492 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1205677004493 active site 1205677004494 catalytic site [active] 1205677004495 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205677004496 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205677004497 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205677004498 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1205677004499 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205677004500 inhibitor-cofactor binding pocket; inhibition site 1205677004501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677004502 catalytic residue [active] 1205677004503 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1205677004504 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1205677004505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677004506 catalytic residue [active] 1205677004507 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1205677004508 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1205677004509 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1205677004510 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677004511 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677004512 active site 1205677004513 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205677004514 Transposase domain (DUF772); Region: DUF772; pfam05598 1205677004515 biotin synthase; Validated; Region: PRK06256 1205677004516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677004517 FeS/SAM binding site; other site 1205677004518 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1205677004519 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1205677004520 Secretory lipase; Region: LIP; pfam03583 1205677004521 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1205677004522 nudix motif; other site 1205677004523 quinolinate synthetase; Provisional; Region: PRK09375 1205677004524 L-aspartate oxidase; Provisional; Region: PRK07804 1205677004525 L-aspartate oxidase; Provisional; Region: PRK06175 1205677004526 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205677004527 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1205677004528 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1205677004529 dimerization interface [polypeptide binding]; other site 1205677004530 active site 1205677004531 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1205677004532 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1205677004533 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1205677004534 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1205677004535 NAD binding site [chemical binding]; other site 1205677004536 dimerization interface [polypeptide binding]; other site 1205677004537 product binding site; other site 1205677004538 substrate binding site [chemical binding]; other site 1205677004539 zinc binding site [ion binding]; other site 1205677004540 catalytic residues [active] 1205677004541 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1205677004542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677004543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677004544 homodimer interface [polypeptide binding]; other site 1205677004545 catalytic residue [active] 1205677004546 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1205677004547 4-fold oligomerization interface [polypeptide binding]; other site 1205677004548 putative active site pocket [active] 1205677004549 metal binding residues [ion binding]; metal-binding site 1205677004550 3-fold/trimer interface [polypeptide binding]; other site 1205677004551 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1205677004552 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1205677004553 putative active site [active] 1205677004554 oxyanion strand; other site 1205677004555 catalytic triad [active] 1205677004556 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1205677004557 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205677004558 catalytic residues [active] 1205677004559 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205677004560 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1205677004561 active site 1205677004562 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1205677004563 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205677004564 substrate binding site [chemical binding]; other site 1205677004565 glutamase interaction surface [polypeptide binding]; other site 1205677004566 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1205677004567 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1205677004568 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1205677004569 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205677004570 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1205677004571 catalytic triad [active] 1205677004572 anthranilate synthase component I; Provisional; Region: PRK13571 1205677004573 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1205677004574 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205677004575 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1205677004576 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1205677004577 active site 1205677004578 ribulose/triose binding site [chemical binding]; other site 1205677004579 phosphate binding site [ion binding]; other site 1205677004580 substrate (anthranilate) binding pocket [chemical binding]; other site 1205677004581 product (indole) binding pocket [chemical binding]; other site 1205677004582 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1205677004583 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1205677004584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677004585 catalytic residue [active] 1205677004586 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1205677004587 substrate binding site [chemical binding]; other site 1205677004588 active site 1205677004589 catalytic residues [active] 1205677004590 heterodimer interface [polypeptide binding]; other site 1205677004591 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1205677004592 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1205677004593 TM2 domain; Region: TM2; pfam05154 1205677004594 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1205677004595 pyruvate kinase; Provisional; Region: PRK06247 1205677004596 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1205677004597 domain interfaces; other site 1205677004598 active site 1205677004599 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1205677004600 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205677004601 active site 1205677004602 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1205677004603 catalytic triad [active] 1205677004604 dimer interface [polypeptide binding]; other site 1205677004605 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1205677004606 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1205677004607 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1205677004608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677004609 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1205677004610 Walker A/P-loop; other site 1205677004611 Walker A/P-loop; other site 1205677004612 ATP binding site [chemical binding]; other site 1205677004613 ATP binding site [chemical binding]; other site 1205677004614 Q-loop/lid; other site 1205677004615 ABC transporter signature motif; other site 1205677004616 Walker B; other site 1205677004617 D-loop; other site 1205677004618 H-loop/switch region; other site 1205677004619 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1205677004620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677004621 Walker A/P-loop; other site 1205677004622 ATP binding site [chemical binding]; other site 1205677004623 Q-loop/lid; other site 1205677004624 ABC transporter signature motif; other site 1205677004625 Walker B; other site 1205677004626 D-loop; other site 1205677004627 H-loop/switch region; other site 1205677004628 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1205677004629 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1205677004630 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1205677004631 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1205677004632 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1205677004633 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1205677004634 cyclase homology domain; Region: CHD; cd07302 1205677004635 nucleotidyl binding site; other site 1205677004636 metal binding site [ion binding]; metal-binding site 1205677004637 dimer interface [polypeptide binding]; other site 1205677004638 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1205677004639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677004640 active site 1205677004641 phosphorylation site [posttranslational modification] 1205677004642 intermolecular recognition site; other site 1205677004643 dimerization interface [polypeptide binding]; other site 1205677004644 ANTAR domain; Region: ANTAR; pfam03861 1205677004645 lipid-transfer protein; Provisional; Region: PRK06059 1205677004646 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205677004647 active site 1205677004648 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205677004649 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1205677004650 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205677004651 DNA polymerase I; Provisional; Region: PRK05755 1205677004652 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1205677004653 active site 1205677004654 metal binding site 1 [ion binding]; metal-binding site 1205677004655 putative 5' ssDNA interaction site; other site 1205677004656 metal binding site 3; metal-binding site 1205677004657 metal binding site 2 [ion binding]; metal-binding site 1205677004658 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1205677004659 putative DNA binding site [nucleotide binding]; other site 1205677004660 putative metal binding site [ion binding]; other site 1205677004661 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1205677004662 active site 1205677004663 substrate binding site [chemical binding]; other site 1205677004664 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1205677004665 active site 1205677004666 DNA binding site [nucleotide binding] 1205677004667 catalytic site [active] 1205677004668 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1205677004669 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1205677004670 RNA binding site [nucleotide binding]; other site 1205677004671 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1205677004672 RNA binding site [nucleotide binding]; other site 1205677004673 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205677004674 RNA binding site [nucleotide binding]; other site 1205677004675 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1205677004676 RNA binding site [nucleotide binding]; other site 1205677004677 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1205677004678 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1205677004679 CoA-binding site [chemical binding]; other site 1205677004680 ATP-binding [chemical binding]; other site 1205677004681 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1205677004682 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1205677004683 excinuclease ABC subunit B; Provisional; Region: PRK05298 1205677004684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677004685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677004686 nucleotide binding region [chemical binding]; other site 1205677004687 ATP-binding site [chemical binding]; other site 1205677004688 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1205677004689 UvrB/uvrC motif; Region: UVR; pfam02151 1205677004690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677004691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205677004692 putative substrate translocation pore; other site 1205677004693 Predicted membrane protein [Function unknown]; Region: COG5305 1205677004694 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677004695 Ligand Binding Site [chemical binding]; other site 1205677004696 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205677004697 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1205677004698 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205677004699 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205677004700 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1205677004701 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1205677004702 Predicted esterase [General function prediction only]; Region: COG0627 1205677004703 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1205677004704 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1205677004705 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1205677004706 dimer interface [polypeptide binding]; other site 1205677004707 putative anticodon binding site; other site 1205677004708 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205677004709 motif 1; other site 1205677004710 dimer interface [polypeptide binding]; other site 1205677004711 active site 1205677004712 motif 2; other site 1205677004713 motif 3; other site 1205677004714 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1205677004715 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1205677004716 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1205677004717 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1205677004718 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1205677004719 23S rRNA binding site [nucleotide binding]; other site 1205677004720 L21 binding site [polypeptide binding]; other site 1205677004721 L13 binding site [polypeptide binding]; other site 1205677004722 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205677004723 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205677004724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205677004725 PE family; Region: PE; pfam00934 1205677004726 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677004727 cyclase homology domain; Region: CHD; cd07302 1205677004728 nucleotidyl binding site; other site 1205677004729 metal binding site [ion binding]; metal-binding site 1205677004730 dimer interface [polypeptide binding]; other site 1205677004731 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1205677004732 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1205677004733 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1205677004734 dimer interface [polypeptide binding]; other site 1205677004735 motif 1; other site 1205677004736 active site 1205677004737 motif 2; other site 1205677004738 motif 3; other site 1205677004739 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1205677004740 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1205677004741 putative tRNA-binding site [nucleotide binding]; other site 1205677004742 B3/4 domain; Region: B3_4; pfam03483 1205677004743 tRNA synthetase B5 domain; Region: B5; smart00874 1205677004744 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1205677004745 dimer interface [polypeptide binding]; other site 1205677004746 motif 1; other site 1205677004747 motif 3; other site 1205677004748 motif 2; other site 1205677004749 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1205677004750 PE family; Region: PE; pfam00934 1205677004751 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1205677004752 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205677004753 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1205677004754 heterotetramer interface [polypeptide binding]; other site 1205677004755 active site pocket [active] 1205677004756 cleavage site 1205677004757 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1205677004758 feedback inhibition sensing region; other site 1205677004759 homohexameric interface [polypeptide binding]; other site 1205677004760 nucleotide binding site [chemical binding]; other site 1205677004761 N-acetyl-L-glutamate binding site [chemical binding]; other site 1205677004762 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1205677004763 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205677004764 inhibitor-cofactor binding pocket; inhibition site 1205677004765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677004766 catalytic residue [active] 1205677004767 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1205677004768 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205677004769 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205677004770 arginine repressor; Region: argR_whole; TIGR01529 1205677004771 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1205677004772 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1205677004773 argininosuccinate synthase; Provisional; Region: PRK13820 1205677004774 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1205677004775 ANP binding site [chemical binding]; other site 1205677004776 Substrate Binding Site II [chemical binding]; other site 1205677004777 Substrate Binding Site I [chemical binding]; other site 1205677004778 argininosuccinate lyase; Provisional; Region: PRK00855 1205677004779 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1205677004780 active sites [active] 1205677004781 tetramer interface [polypeptide binding]; other site 1205677004782 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205677004783 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205677004784 malonyl-CoA binding site [chemical binding]; other site 1205677004785 dimer interface [polypeptide binding]; other site 1205677004786 active site 1205677004787 product binding site; other site 1205677004788 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677004789 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677004790 active site 1205677004791 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677004792 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677004793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677004794 Enoylreductase; Region: PKS_ER; smart00829 1205677004795 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205677004796 NAD(P) binding site [chemical binding]; other site 1205677004797 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205677004798 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205677004799 putative NADP binding site [chemical binding]; other site 1205677004800 active site 1205677004801 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677004802 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677004803 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677004804 active site 1205677004805 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677004806 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677004807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677004808 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205677004809 Enoylreductase; Region: PKS_ER; smart00829 1205677004810 NAD(P) binding site [chemical binding]; other site 1205677004811 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205677004812 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205677004813 putative NADP binding site [chemical binding]; other site 1205677004814 active site 1205677004815 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677004816 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677004817 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205677004818 active site 1205677004819 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205677004820 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677004821 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677004822 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205677004823 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205677004824 malonyl-CoA binding site [chemical binding]; other site 1205677004825 dimer interface [polypeptide binding]; other site 1205677004826 active site 1205677004827 product binding site; other site 1205677004828 Cytochrome P450; Region: p450; cl12078 1205677004829 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677004830 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205677004831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205677004832 ABC transporter; Region: ABC_tran_2; pfam12848 1205677004833 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205677004834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205677004835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677004836 putative substrate translocation pore; other site 1205677004837 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205677004838 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205677004839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677004840 dimerization interface [polypeptide binding]; other site 1205677004841 putative DNA binding site [nucleotide binding]; other site 1205677004842 putative Zn2+ binding site [ion binding]; other site 1205677004843 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1205677004844 active site residue [active] 1205677004845 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677004846 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677004847 ligand binding site [chemical binding]; other site 1205677004848 flexible hinge region; other site 1205677004849 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1205677004850 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1205677004851 putative catalytic residues [active] 1205677004852 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1205677004853 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205677004854 catalytic residues [active] 1205677004855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677004856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677004857 active site 1205677004858 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1205677004859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205677004860 substrate binding pocket [chemical binding]; other site 1205677004861 membrane-bound complex binding site; other site 1205677004862 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1205677004863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677004864 FeS/SAM binding site; other site 1205677004865 DivIVA protein; Region: DivIVA; pfam05103 1205677004866 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205677004867 acyl-CoA synthetase; Validated; Region: PRK07868 1205677004868 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1205677004869 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677004870 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677004871 acyl-activating enzyme (AAE) consensus motif; other site 1205677004872 AMP binding site [chemical binding]; other site 1205677004873 active site 1205677004874 CoA binding site [chemical binding]; other site 1205677004875 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1205677004876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677004877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677004878 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205677004879 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205677004880 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205677004881 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1205677004882 Walker A/P-loop; other site 1205677004883 ATP binding site [chemical binding]; other site 1205677004884 Q-loop/lid; other site 1205677004885 ABC transporter signature motif; other site 1205677004886 Walker B; other site 1205677004887 D-loop; other site 1205677004888 H-loop/switch region; other site 1205677004889 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1205677004890 active site 1205677004891 DNA binding site [nucleotide binding] 1205677004892 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1205677004893 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1205677004894 active site 1205677004895 HIGH motif; other site 1205677004896 dimer interface [polypeptide binding]; other site 1205677004897 KMSKS motif; other site 1205677004898 S4 RNA-binding domain; Region: S4; smart00363 1205677004899 RNA binding surface [nucleotide binding]; other site 1205677004900 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677004901 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1205677004902 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205677004903 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1205677004904 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205677004905 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1205677004906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205677004907 RNA binding surface [nucleotide binding]; other site 1205677004908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677004909 S-adenosylmethionine binding site [chemical binding]; other site 1205677004910 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1205677004911 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1205677004912 DNA repair protein RecN; Region: recN; TIGR00634 1205677004913 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205677004914 Walker A/P-loop; other site 1205677004915 ATP binding site [chemical binding]; other site 1205677004916 Q-loop/lid; other site 1205677004917 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205677004918 ABC transporter signature motif; other site 1205677004919 Walker B; other site 1205677004920 D-loop; other site 1205677004921 H-loop/switch region; other site 1205677004922 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1205677004923 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1205677004924 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1205677004925 CTP synthetase; Validated; Region: pyrG; PRK05380 1205677004926 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1205677004927 Catalytic site [active] 1205677004928 active site 1205677004929 UTP binding site [chemical binding]; other site 1205677004930 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1205677004931 active site 1205677004932 putative oxyanion hole; other site 1205677004933 catalytic triad [active] 1205677004934 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1205677004935 dimer interface [polypeptide binding]; other site 1205677004936 ADP-ribose binding site [chemical binding]; other site 1205677004937 active site 1205677004938 nudix motif; other site 1205677004939 metal binding site [ion binding]; metal-binding site 1205677004940 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1205677004941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205677004942 active site 1205677004943 DNA binding site [nucleotide binding] 1205677004944 Int/Topo IB signature motif; other site 1205677004945 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677004946 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677004947 active site 1205677004948 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1205677004949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677004950 ATP binding site [chemical binding]; other site 1205677004951 putative Mg++ binding site [ion binding]; other site 1205677004952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677004953 nucleotide binding region [chemical binding]; other site 1205677004954 ATP-binding site [chemical binding]; other site 1205677004955 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205677004956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677004957 S-adenosylmethionine binding site [chemical binding]; other site 1205677004958 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1205677004959 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677004960 PPE family; Region: PPE; pfam00823 1205677004961 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677004962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677004963 PPE family; Region: PPE; pfam00823 1205677004964 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677004965 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205677004966 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205677004967 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205677004968 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205677004969 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205677004970 P-loop; other site 1205677004971 Magnesium ion binding site [ion binding]; other site 1205677004972 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205677004973 Magnesium ion binding site [ion binding]; other site 1205677004974 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1205677004975 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1205677004976 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1205677004977 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205677004978 RNA binding surface [nucleotide binding]; other site 1205677004979 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1205677004980 active site 1205677004981 cytidylate kinase; Provisional; Region: cmk; PRK00023 1205677004982 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1205677004983 CMP-binding site; other site 1205677004984 The sites determining sugar specificity; other site 1205677004985 GTP-binding protein Der; Reviewed; Region: PRK03003 1205677004986 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1205677004987 GTP/Mg2+ binding site [chemical binding]; other site 1205677004988 Switch I region; other site 1205677004989 G2 box; other site 1205677004990 Switch II region; other site 1205677004991 G3 box; other site 1205677004992 G4 box; other site 1205677004993 G5 box; other site 1205677004994 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1205677004995 G1 box; other site 1205677004996 GTP/Mg2+ binding site [chemical binding]; other site 1205677004997 Switch I region; other site 1205677004998 G2 box; other site 1205677004999 G3 box; other site 1205677005000 Switch II region; other site 1205677005001 G4 box; other site 1205677005002 G5 box; other site 1205677005003 short chain dehydrogenase; Provisional; Region: PRK07060 1205677005004 classical (c) SDRs; Region: SDR_c; cd05233 1205677005005 NAD(P) binding site [chemical binding]; other site 1205677005006 active site 1205677005007 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1205677005008 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205677005009 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205677005010 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1205677005011 Cupin domain; Region: Cupin_2; pfam07883 1205677005012 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1205677005013 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205677005014 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205677005015 putative switch regulator; other site 1205677005016 non-specific DNA interactions [nucleotide binding]; other site 1205677005017 DNA binding site [nucleotide binding] 1205677005018 sequence specific DNA binding site [nucleotide binding]; other site 1205677005019 putative cAMP binding site [chemical binding]; other site 1205677005020 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205677005021 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1205677005022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677005023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205677005024 non-specific DNA binding site [nucleotide binding]; other site 1205677005025 salt bridge; other site 1205677005026 sequence-specific DNA binding site [nucleotide binding]; other site 1205677005027 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1205677005028 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205677005029 putative active site [active] 1205677005030 homotetrameric interface [polypeptide binding]; other site 1205677005031 metal binding site [ion binding]; metal-binding site 1205677005032 biotin carboxylase-like protein; Validated; Region: PRK06524 1205677005033 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205677005034 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677005035 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677005036 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205677005037 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677005038 dimerization interface [polypeptide binding]; other site 1205677005039 putative DNA binding site [nucleotide binding]; other site 1205677005040 putative Zn2+ binding site [ion binding]; other site 1205677005041 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205677005042 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677005043 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677005044 Berberine and berberine like; Region: BBE; pfam08031 1205677005045 TIGR03086 family protein; Region: TIGR03086 1205677005046 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205677005047 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677005048 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677005049 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677005050 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677005051 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1205677005052 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1205677005053 NAD(P) binding site [chemical binding]; other site 1205677005054 catalytic residues [active] 1205677005055 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1205677005056 putative catalytic residue [active] 1205677005057 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205677005058 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1205677005059 gating phenylalanine in ion channel; other site 1205677005060 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10483724, 11416222, 12379712, 12694625; Product type e : enzyme 1205677005061 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10483724, 11416222, 12379712, 12694625; Product type pe : putative enzyme 1205677005062 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1205677005063 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1205677005064 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1205677005065 [4Fe-4S] binding site [ion binding]; other site 1205677005066 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677005067 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677005068 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677005069 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1205677005070 molybdopterin cofactor binding site; other site 1205677005071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677005072 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1205677005073 putative substrate translocation pore; other site 1205677005074 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1205677005075 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205677005076 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1205677005077 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205677005078 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205677005079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205677005080 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1205677005081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677005082 active site 1205677005083 ATP binding site [chemical binding]; other site 1205677005084 substrate binding site [chemical binding]; other site 1205677005085 activation loop (A-loop); other site 1205677005086 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1205677005087 Thioredoxin; Region: Thioredoxin_4; cl17273 1205677005088 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1205677005089 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1205677005090 active site 1205677005091 metal binding site [ion binding]; metal-binding site 1205677005092 nudix motif; other site 1205677005093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677005094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677005095 active site 1205677005096 ATP binding site [chemical binding]; other site 1205677005097 substrate binding site [chemical binding]; other site 1205677005098 activation loop (A-loop); other site 1205677005099 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677005100 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677005101 phosphopeptide binding site; other site 1205677005102 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677005103 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677005104 phosphopeptide binding site; other site 1205677005105 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1205677005106 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1205677005107 Walker A/P-loop; other site 1205677005108 ATP binding site [chemical binding]; other site 1205677005109 Q-loop/lid; other site 1205677005110 ABC transporter signature motif; other site 1205677005111 Walker B; other site 1205677005112 D-loop; other site 1205677005113 H-loop/switch region; other site 1205677005114 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205677005115 acyl-CoA synthetase; Provisional; Region: PRK13388 1205677005116 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677005117 acyl-activating enzyme (AAE) consensus motif; other site 1205677005118 AMP binding site [chemical binding]; other site 1205677005119 active site 1205677005120 CoA binding site [chemical binding]; other site 1205677005121 hypothetical protein; Provisional; Region: PRK06185 1205677005122 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205677005123 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205677005124 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005125 PPE family; Region: PPE; pfam00823 1205677005126 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005127 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677005128 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677005129 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1205677005130 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205677005131 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205677005132 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205677005133 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1205677005134 sulfite oxidase; Provisional; Region: PLN00177 1205677005135 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1205677005136 Moco binding site; other site 1205677005137 metal coordination site [ion binding]; other site 1205677005138 dimerization interface [polypeptide binding]; other site 1205677005139 Transport protein; Region: actII; TIGR00833 1205677005140 Cutinase; Region: Cutinase; pfam01083 1205677005141 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677005142 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677005143 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1205677005144 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1205677005145 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677005146 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677005147 active site 1205677005148 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205677005149 putative homotetramer interface [polypeptide binding]; other site 1205677005150 putative homodimer interface [polypeptide binding]; other site 1205677005151 putative allosteric switch controlling residues; other site 1205677005152 putative metal binding site [ion binding]; other site 1205677005153 putative homodimer-homodimer interface [polypeptide binding]; other site 1205677005154 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1205677005155 PE family; Region: PE; pfam00934 1205677005156 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205677005157 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1205677005158 dimer interface [polypeptide binding]; other site 1205677005159 active site 1205677005160 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205677005161 substrate binding site [chemical binding]; other site 1205677005162 catalytic residue [active] 1205677005163 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1205677005164 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205677005165 metal binding site [ion binding]; metal-binding site 1205677005166 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1205677005167 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677005168 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205677005169 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205677005170 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205677005171 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205677005172 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677005173 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677005174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677005175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677005176 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677005177 Cytochrome P450; Region: p450; cl12078 1205677005178 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1205677005179 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1205677005180 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1205677005181 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205677005182 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205677005183 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677005184 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205677005185 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677005186 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677005187 Cytochrome P450; Region: p450; cl12078 1205677005188 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205677005189 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005190 PPE family; Region: PPE; pfam00823 1205677005191 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677005192 PE family; Region: PE; pfam00934 1205677005193 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205677005194 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205677005195 EspG family; Region: ESX-1_EspG; pfam14011 1205677005196 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205677005197 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205677005198 catalytic residues [active] 1205677005199 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205677005200 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1205677005201 active site 1205677005202 catalytic residues [active] 1205677005203 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205677005204 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205677005205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677005206 Walker A motif; other site 1205677005207 ATP binding site [chemical binding]; other site 1205677005208 Walker B motif; other site 1205677005209 arginine finger; other site 1205677005210 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005211 PPE family; Region: PPE; pfam00823 1205677005212 PE-PPE domain; Region: PE-PPE; pfam08237 1205677005213 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005214 PPE family; Region: PPE; pfam00823 1205677005215 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005216 PPE family; Region: PPE; pfam00823 1205677005217 PE family; Region: PE; pfam00934 1205677005218 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677005219 PE family; Region: PE; pfam00934 1205677005220 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005221 PPE family; Region: PPE; pfam00823 1205677005222 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005223 PPE family; Region: PPE; pfam00823 1205677005224 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005225 PPE family; Region: PPE; pfam00823 1205677005226 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677005227 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677005228 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1205677005229 MgtC family; Region: MgtC; pfam02308 1205677005230 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12694625, 12775759, 15525680, 17443846; Product type pe : putative enzyme 1205677005231 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12694625, 12775759, 15525680, 17443846; Product type pe : putative enzyme 1205677005232 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1205677005233 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1205677005234 hypothetical protein; Validated; Region: PRK07121 1205677005235 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205677005236 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1205677005237 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1205677005238 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1205677005239 hypothetical protein; Provisional; Region: PRK05858 1205677005240 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205677005241 PYR/PP interface [polypeptide binding]; other site 1205677005242 dimer interface [polypeptide binding]; other site 1205677005243 TPP binding site [chemical binding]; other site 1205677005244 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205677005245 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1205677005246 TPP-binding site; other site 1205677005247 dimer interface [polypeptide binding]; other site 1205677005248 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1205677005249 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1205677005250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205677005251 nucleotide binding region [chemical binding]; other site 1205677005252 ATP-binding site [chemical binding]; other site 1205677005253 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205677005254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205677005255 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205677005256 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1205677005257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205677005258 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205677005259 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1205677005260 lipoyl attachment site [posttranslational modification]; other site 1205677005261 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677005262 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677005263 phosphopeptide binding site; other site 1205677005264 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1205677005265 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205677005266 DNA binding residues [nucleotide binding] 1205677005267 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1205677005268 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1205677005269 DNA binding residues [nucleotide binding] 1205677005270 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205677005271 putative dimer interface [polypeptide binding]; other site 1205677005272 glycine dehydrogenase; Provisional; Region: PRK05367 1205677005273 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1205677005274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677005275 tetramer interface [polypeptide binding]; other site 1205677005276 catalytic residue [active] 1205677005277 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1205677005278 tetramer interface [polypeptide binding]; other site 1205677005279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677005280 catalytic residue [active] 1205677005281 haloalkane dehalogenase; Provisional; Region: PRK03204 1205677005282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205677005283 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1205677005284 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1205677005285 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205677005286 metal ion-dependent adhesion site (MIDAS); other site 1205677005287 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1205677005288 active site 1205677005289 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205677005290 putative active site [active] 1205677005291 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205677005292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205677005293 FOG: CBS domain [General function prediction only]; Region: COG0517 1205677005294 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205677005295 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205677005296 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205677005297 Transporter associated domain; Region: CorC_HlyC; smart01091 1205677005298 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1205677005299 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205677005300 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205677005301 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205677005302 active site 1205677005303 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205677005304 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1205677005305 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1205677005306 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1205677005307 Predicted transcriptional regulator [Transcription]; Region: COG3682 1205677005308 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205677005309 CoenzymeA binding site [chemical binding]; other site 1205677005310 subunit interaction site [polypeptide binding]; other site 1205677005311 PHB binding site; other site 1205677005312 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1205677005313 alpha-gamma subunit interface [polypeptide binding]; other site 1205677005314 beta-gamma subunit interface [polypeptide binding]; other site 1205677005315 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1205677005316 gamma-beta subunit interface [polypeptide binding]; other site 1205677005317 alpha-beta subunit interface [polypeptide binding]; other site 1205677005318 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1205677005319 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1205677005320 subunit interactions [polypeptide binding]; other site 1205677005321 active site 1205677005322 flap region; other site 1205677005323 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1205677005324 UreF; Region: UreF; pfam01730 1205677005325 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205677005326 UreD urease accessory protein; Region: UreD; cl00530 1205677005327 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205677005328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677005329 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677005330 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205677005331 classical (c) SDRs; Region: SDR_c; cd05233 1205677005332 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1205677005333 NAD(P) binding site [chemical binding]; other site 1205677005334 active site 1205677005335 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1205677005336 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205677005337 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205677005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677005339 dimer interface [polypeptide binding]; other site 1205677005340 conserved gate region; other site 1205677005341 putative PBP binding loops; other site 1205677005342 ABC-ATPase subunit interface; other site 1205677005343 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1205677005344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677005345 Walker A/P-loop; other site 1205677005346 ATP binding site [chemical binding]; other site 1205677005347 Q-loop/lid; other site 1205677005348 ABC transporter signature motif; other site 1205677005349 Walker B; other site 1205677005350 D-loop; other site 1205677005351 H-loop/switch region; other site 1205677005352 TOBE domain; Region: TOBE; pfam03459 1205677005353 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1205677005354 Predicted membrane protein [Function unknown]; Region: COG2261 1205677005355 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1205677005356 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1205677005357 putative NAD(P) binding site [chemical binding]; other site 1205677005358 putative substrate binding site [chemical binding]; other site 1205677005359 catalytic Zn binding site [ion binding]; other site 1205677005360 structural Zn binding site [ion binding]; other site 1205677005361 CAAX protease self-immunity; Region: Abi; pfam02517 1205677005362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1205677005363 MOSC domain; Region: MOSC; pfam03473 1205677005364 short chain dehydrogenase; Provisional; Region: PRK07825 1205677005365 classical (c) SDRs; Region: SDR_c; cd05233 1205677005366 NAD(P) binding site [chemical binding]; other site 1205677005367 active site 1205677005368 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205677005369 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205677005370 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205677005371 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205677005372 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1205677005373 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205677005374 active site 1205677005375 hypothetical protein; Provisional; Region: PRK12320 1205677005376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677005377 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1205677005378 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677005379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677005380 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1205677005381 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205677005382 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1205677005383 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1205677005384 active site 1205677005385 substrate binding site [chemical binding]; other site 1205677005386 FMN binding site [chemical binding]; other site 1205677005387 putative catalytic residues [active] 1205677005388 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1205677005389 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205677005390 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1205677005391 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1205677005392 heme binding site [chemical binding]; other site 1205677005393 ferroxidase pore; other site 1205677005394 ferroxidase diiron center [ion binding]; other site 1205677005395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677005396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205677005397 putative substrate translocation pore; other site 1205677005398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677005399 putative substrate translocation pore; other site 1205677005400 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205677005401 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205677005402 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205677005403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677005404 Cytochrome P450; Region: p450; cl12078 1205677005405 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1205677005406 short chain dehydrogenase; Provisional; Region: PRK08267 1205677005407 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1205677005408 putative NAD(P) binding site [chemical binding]; other site 1205677005409 active site 1205677005410 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205677005411 hydrophobic ligand binding site; other site 1205677005412 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205677005413 chorismate mutase; Provisional; Region: PRK09269 1205677005414 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1205677005415 Putative esterase; Region: Esterase; pfam00756 1205677005416 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677005417 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677005418 YceI-like domain; Region: YceI; cl01001 1205677005419 Nitronate monooxygenase; Region: NMO; pfam03060 1205677005420 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205677005421 FMN binding site [chemical binding]; other site 1205677005422 substrate binding site [chemical binding]; other site 1205677005423 putative catalytic residue [active] 1205677005424 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1205677005425 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205677005426 catalytic Zn binding site [ion binding]; other site 1205677005427 NAD(P) binding site [chemical binding]; other site 1205677005428 structural Zn binding site [ion binding]; other site 1205677005429 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677005430 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677005431 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1205677005432 putative active site [active] 1205677005433 dimerization interface [polypeptide binding]; other site 1205677005434 putative tRNAtyr binding site [nucleotide binding]; other site 1205677005435 Domain of unknown function DUF77; Region: DUF77; pfam01910 1205677005436 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1205677005437 putative ADP-ribose binding site [chemical binding]; other site 1205677005438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677005439 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677005440 cyclase homology domain; Region: CHD; cd07302 1205677005441 nucleotidyl binding site; other site 1205677005442 metal binding site [ion binding]; metal-binding site 1205677005443 dimer interface [polypeptide binding]; other site 1205677005444 competence damage-inducible protein A; Provisional; Region: PRK00549 1205677005445 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1205677005446 putative MPT binding site; other site 1205677005447 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1205677005448 putative sialic acid transporter; Region: 2A0112; TIGR00891 1205677005449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677005450 putative substrate translocation pore; other site 1205677005451 Predicted membrane protein [Function unknown]; Region: COG1950 1205677005452 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205677005453 anti sigma factor interaction site; other site 1205677005454 regulatory phosphorylation site [posttranslational modification]; other site 1205677005455 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1205677005456 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1205677005457 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1205677005458 dimer interface [polypeptide binding]; other site 1205677005459 active site 1205677005460 heme binding site [chemical binding]; other site 1205677005461 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1205677005462 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205677005463 metal binding site 2 [ion binding]; metal-binding site 1205677005464 putative DNA binding helix; other site 1205677005465 metal binding site 1 [ion binding]; metal-binding site 1205677005466 dimer interface [polypeptide binding]; other site 1205677005467 structural Zn2+ binding site [ion binding]; other site 1205677005468 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205677005469 substrate binding site [chemical binding]; other site 1205677005470 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205677005471 substrate binding site [chemical binding]; other site 1205677005472 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205677005473 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1205677005474 putative NAD(P) binding site [chemical binding]; other site 1205677005475 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205677005476 Integrase core domain; Region: rve; pfam00665 1205677005477 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205677005478 tetramer interface [polypeptide binding]; other site 1205677005479 active site 1205677005480 Mg2+/Mn2+ binding site [ion binding]; other site 1205677005481 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1205677005482 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005483 PPE family; Region: PPE; pfam00823 1205677005484 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677005485 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005486 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677005487 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677005488 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005489 PPE family; Region: PPE; pfam00823 1205677005490 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677005491 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205677005492 putative hydrophobic ligand binding site [chemical binding]; other site 1205677005493 protein interface [polypeptide binding]; other site 1205677005494 gate; other site 1205677005495 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677005496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205677005497 putative acyl-acceptor binding pocket; other site 1205677005498 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205677005499 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677005500 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677005501 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677005502 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677005503 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1205677005504 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677005505 acyl-activating enzyme (AAE) consensus motif; other site 1205677005506 active site 1205677005507 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1205677005508 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1205677005509 short chain dehydrogenase; Provisional; Region: PRK05867 1205677005510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677005511 NAD(P) binding site [chemical binding]; other site 1205677005512 active site 1205677005513 TIGR03085 family protein; Region: TIGR03085 1205677005514 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1205677005515 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1205677005516 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1205677005517 conserved cys residue [active] 1205677005518 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1205677005519 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1205677005520 conserved cys residue [active] 1205677005521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205677005522 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1205677005523 dimer interface [polypeptide binding]; other site 1205677005524 catalytic triad [active] 1205677005525 peroxidatic and resolving cysteines [active] 1205677005526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677005527 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205677005528 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205677005529 active site 1205677005530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677005531 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205677005532 FAD binding site [chemical binding]; other site 1205677005533 substrate binding site [chemical binding]; other site 1205677005534 catalytic base [active] 1205677005535 enoyl-CoA hydratase; Provisional; Region: PRK08290 1205677005536 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677005537 substrate binding site [chemical binding]; other site 1205677005538 oxyanion hole (OAH) forming residues; other site 1205677005539 trimer interface [polypeptide binding]; other site 1205677005540 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677005541 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205677005542 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1205677005543 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677005544 catalytic loop [active] 1205677005545 iron binding site [ion binding]; other site 1205677005546 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1205677005547 FAD binding pocket [chemical binding]; other site 1205677005548 FAD binding motif [chemical binding]; other site 1205677005549 phosphate binding motif [ion binding]; other site 1205677005550 beta-alpha-beta structure motif; other site 1205677005551 NAD binding pocket [chemical binding]; other site 1205677005552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677005553 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205677005554 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205677005555 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1205677005556 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1205677005557 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1205677005558 dimerization interface [polypeptide binding]; other site 1205677005559 active site 1205677005560 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1205677005561 putative NAD(P) binding site [chemical binding]; other site 1205677005562 active site 1205677005563 homodimer interface [polypeptide binding]; other site 1205677005564 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205677005565 SEC-C motif; Region: SEC-C; pfam02810 1205677005566 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677005567 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677005568 active site 1205677005569 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205677005570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677005571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677005572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677005573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677005574 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677005575 Permease; Region: Permease; pfam02405 1205677005576 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677005577 Permease; Region: Permease; pfam02405 1205677005578 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677005579 mce related protein; Region: MCE; pfam02470 1205677005580 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677005581 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677005582 mce related protein; Region: MCE; pfam02470 1205677005583 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677005584 mce related protein; Region: MCE; pfam02470 1205677005585 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677005586 mce related protein; Region: MCE; pfam02470 1205677005587 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677005588 mce related protein; Region: MCE; pfam02470 1205677005589 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677005590 mce related protein; Region: MCE; pfam02470 1205677005591 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677005592 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1205677005593 YacP-like NYN domain; Region: NYN_YacP; cl01491 1205677005594 PE family; Region: PE; pfam00934 1205677005595 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205677005596 Peptidase family M48; Region: Peptidase_M48; pfam01435 1205677005597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677005598 S-adenosylmethionine binding site [chemical binding]; other site 1205677005599 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205677005600 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1205677005601 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1205677005602 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1205677005603 dimer interface [polypeptide binding]; other site 1205677005604 putative radical transfer pathway; other site 1205677005605 diiron center [ion binding]; other site 1205677005606 tyrosyl radical; other site 1205677005607 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205677005608 putative active site [active] 1205677005609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205677005610 PE family; Region: PE; pfam00934 1205677005611 Cutinase; Region: Cutinase; pfam01083 1205677005612 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1205677005613 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1205677005614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205677005615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205677005616 dimerization interface [polypeptide binding]; other site 1205677005617 Lysine efflux permease [General function prediction only]; Region: COG1279 1205677005618 Cellulose binding domain; Region: CBM_2; pfam00553 1205677005619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677005620 S-adenosylmethionine binding site [chemical binding]; other site 1205677005621 PemK-like protein; Region: PemK; pfam02452 1205677005622 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205677005623 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677005624 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1205677005625 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677005626 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205677005627 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677005628 dimerization interface [polypeptide binding]; other site 1205677005629 putative DNA binding site [nucleotide binding]; other site 1205677005630 putative Zn2+ binding site [ion binding]; other site 1205677005631 Hemerythrin-like domain; Region: Hr-like; cd12108 1205677005632 Fe binding site [ion binding]; other site 1205677005633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677005634 Ligand Binding Site [chemical binding]; other site 1205677005635 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677005636 Ligand Binding Site [chemical binding]; other site 1205677005637 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205677005638 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1205677005639 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677005640 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1205677005641 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205677005642 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205677005643 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205677005644 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1205677005645 tetramer interface [polypeptide binding]; other site 1205677005646 active site 1205677005647 Mg2+/Mn2+ binding site [ion binding]; other site 1205677005648 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205677005649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205677005650 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1205677005651 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1205677005652 homotetramer interface [polypeptide binding]; other site 1205677005653 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205677005654 NAD binding site [chemical binding]; other site 1205677005655 homodimer interface [polypeptide binding]; other site 1205677005656 active site 1205677005657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677005658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1205677005659 Predicted kinase [General function prediction only]; Region: COG0645 1205677005660 AAA domain; Region: AAA_17; pfam13207 1205677005661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677005662 Ligand Binding Site [chemical binding]; other site 1205677005663 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677005664 Ligand Binding Site [chemical binding]; other site 1205677005665 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1205677005666 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1205677005667 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1205677005668 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1205677005669 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1205677005670 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1205677005671 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1205677005672 Ferredoxin [Energy production and conversion]; Region: COG1146 1205677005673 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205677005674 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205677005675 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677005676 Walker A motif; other site 1205677005677 ATP binding site [chemical binding]; other site 1205677005678 Walker B motif; other site 1205677005679 arginine finger; other site 1205677005680 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205677005681 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677005682 putative active site [active] 1205677005683 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205677005684 MarR family; Region: MarR_2; pfam12802 1205677005685 Phage envelope protein [General function prediction only]; Region: COG5562 1205677005686 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677005687 active site 1205677005688 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205677005689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205677005690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677005691 non-specific DNA binding site [nucleotide binding]; other site 1205677005692 salt bridge; other site 1205677005693 sequence-specific DNA binding site [nucleotide binding]; other site 1205677005694 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1205677005695 Protein of unknown function (DUF433); Region: DUF433; cl01030 1205677005696 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677005697 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1205677005698 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1205677005699 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1205677005700 Predicted helicase [General function prediction only]; Region: COG4889 1205677005701 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205677005702 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1205677005703 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205677005704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677005705 ATP binding site [chemical binding]; other site 1205677005706 putative Mg++ binding site [ion binding]; other site 1205677005707 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1205677005708 ATP-binding site [chemical binding]; other site 1205677005709 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1205677005710 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1205677005711 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677005712 Ligand Binding Site [chemical binding]; other site 1205677005713 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677005714 Ligand Binding Site [chemical binding]; other site 1205677005715 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205677005716 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205677005717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205677005718 Histidine kinase; Region: HisKA_3; pfam07730 1205677005719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677005720 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1205677005721 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1205677005722 putative substrate binding site [chemical binding]; other site 1205677005723 putative ATP binding site [chemical binding]; other site 1205677005724 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677005725 active site 1205677005726 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1205677005727 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1205677005728 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1205677005729 putative dimer interface [polypeptide binding]; other site 1205677005730 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205677005731 dimer interface [polypeptide binding]; other site 1205677005732 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1205677005733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677005734 putative DNA binding site [nucleotide binding]; other site 1205677005735 dimerization interface [polypeptide binding]; other site 1205677005736 putative Zn2+ binding site [ion binding]; other site 1205677005737 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1205677005738 putative hydrophobic ligand binding site [chemical binding]; other site 1205677005739 CLM binding site; other site 1205677005740 L1 loop; other site 1205677005741 DNA binding site [nucleotide binding] 1205677005742 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205677005743 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205677005744 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1205677005745 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205677005746 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1205677005747 nucleophile elbow; other site 1205677005748 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205677005749 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205677005750 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205677005751 Walker A/P-loop; other site 1205677005752 ATP binding site [chemical binding]; other site 1205677005753 Q-loop/lid; other site 1205677005754 ABC transporter signature motif; other site 1205677005755 Walker B; other site 1205677005756 D-loop; other site 1205677005757 H-loop/switch region; other site 1205677005758 TOBE domain; Region: TOBE_2; pfam08402 1205677005759 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205677005760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677005761 dimer interface [polypeptide binding]; other site 1205677005762 conserved gate region; other site 1205677005763 putative PBP binding loops; other site 1205677005764 ABC-ATPase subunit interface; other site 1205677005765 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1205677005766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677005767 dimer interface [polypeptide binding]; other site 1205677005768 conserved gate region; other site 1205677005769 putative PBP binding loops; other site 1205677005770 ABC-ATPase subunit interface; other site 1205677005771 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205677005772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205677005773 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1205677005774 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1205677005775 Isochorismatase family; Region: Isochorismatase; pfam00857 1205677005776 catalytic triad [active] 1205677005777 metal binding site [ion binding]; metal-binding site 1205677005778 conserved cis-peptide bond; other site 1205677005779 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1205677005780 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1205677005781 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677005782 substrate binding pocket [chemical binding]; other site 1205677005783 catalytic triad [active] 1205677005784 hypothetical protein; Provisional; Region: PRK05865 1205677005785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677005786 NAD(P) binding site [chemical binding]; other site 1205677005787 active site 1205677005788 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1205677005789 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12775759, 12819062, 15525680; Product type e : enzyme 1205677005790 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12775759, 12819062, 15525680; Product type e : enzyme 1205677005791 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1205677005792 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1205677005793 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1205677005794 putative active site [active] 1205677005795 catalytic triad [active] 1205677005796 putative dimer interface [polypeptide binding]; other site 1205677005797 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1205677005798 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1205677005799 Ligand binding site; other site 1205677005800 Putative Catalytic site; other site 1205677005801 DXD motif; other site 1205677005802 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1205677005803 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1205677005804 active site 1205677005805 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1205677005806 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1205677005807 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1205677005808 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1205677005809 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1205677005810 putative active site [active] 1205677005811 Evidence 5 : No homology to any previously reported sequences 1205677005812 Evidence 5 : No homology to any previously reported sequences 1205677005813 30S ribosomal protein S18; Provisional; Region: PRK13401 1205677005814 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1205677005815 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1205677005816 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205677005817 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1205677005818 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1205677005819 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205677005820 intersubunit interface [polypeptide binding]; other site 1205677005821 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1205677005822 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1205677005823 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1205677005824 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1205677005825 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1205677005826 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1205677005827 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205677005828 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205677005829 PemK-like protein; Region: PemK; pfam02452 1205677005830 precorrin-3B synthase; Region: CobG; TIGR02435 1205677005831 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205677005832 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1205677005833 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1205677005834 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1205677005835 active site 1205677005836 SAM binding site [chemical binding]; other site 1205677005837 homodimer interface [polypeptide binding]; other site 1205677005838 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1205677005839 active site 1205677005840 SAM binding site [chemical binding]; other site 1205677005841 homodimer interface [polypeptide binding]; other site 1205677005842 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677005843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677005844 S-adenosylmethionine binding site [chemical binding]; other site 1205677005845 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1205677005846 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205677005847 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1205677005848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677005849 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677005850 DNA binding residues [nucleotide binding] 1205677005851 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1205677005852 precorrin-6x reductase; Region: precor6x_red; TIGR00715 1205677005853 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1205677005854 active site 1205677005855 SAM binding site [chemical binding]; other site 1205677005856 homodimer interface [polypeptide binding]; other site 1205677005857 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1205677005858 active site 1205677005859 putative homodimer interface [polypeptide binding]; other site 1205677005860 SAM binding site [chemical binding]; other site 1205677005861 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1205677005862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677005863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677005864 NAD(P) binding site [chemical binding]; other site 1205677005865 active site 1205677005866 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205677005867 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1205677005868 putative active site [active] 1205677005869 catalytic site [active] 1205677005870 putative metal binding site [ion binding]; other site 1205677005871 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1205677005872 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1205677005873 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205677005874 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1205677005875 Helix-turn-helix domain; Region: HTH_28; pfam13518 1205677005876 Winged helix-turn helix; Region: HTH_29; pfam13551 1205677005877 Homeodomain-like domain; Region: HTH_32; pfam13565 1205677005878 Integrase core domain; Region: rve; pfam00665 1205677005879 Integrase core domain; Region: rve_3; pfam13683 1205677005880 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1205677005881 Evidence 4 : Homologs of previously reported genes of unknown function 1205677005882 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677005883 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677005884 active site 1205677005885 ATP binding site [chemical binding]; other site 1205677005886 substrate binding site [chemical binding]; other site 1205677005887 activation loop (A-loop); other site 1205677005888 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677005889 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1205677005890 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1205677005891 active site 1205677005892 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1205677005893 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1205677005894 active site 1205677005895 metal binding site 1 [ion binding]; metal-binding site 1205677005896 putative 5' ssDNA interaction site; other site 1205677005897 metal binding site 3; metal-binding site 1205677005898 metal binding site 2 [ion binding]; metal-binding site 1205677005899 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1205677005900 putative DNA binding site [nucleotide binding]; other site 1205677005901 putative metal binding site [ion binding]; other site 1205677005902 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205677005903 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1205677005904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677005905 ATP binding site [chemical binding]; other site 1205677005906 putative Mg++ binding site [ion binding]; other site 1205677005907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677005908 nucleotide binding region [chemical binding]; other site 1205677005909 ATP-binding site [chemical binding]; other site 1205677005910 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1205677005911 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1205677005912 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1205677005913 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1205677005914 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205677005915 WYL domain; Region: WYL; pfam13280 1205677005916 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205677005917 WYL domain; Region: WYL; pfam13280 1205677005918 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1205677005919 PE family; Region: PE; pfam00934 1205677005920 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677005921 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677005922 active site 1205677005923 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1205677005924 SNF2 Helicase protein; Region: DUF3670; pfam12419 1205677005925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677005926 ATP binding site [chemical binding]; other site 1205677005927 putative Mg++ binding site [ion binding]; other site 1205677005928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677005929 nucleotide binding region [chemical binding]; other site 1205677005930 ATP-binding site [chemical binding]; other site 1205677005931 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1205677005932 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205677005933 putative active site [active] 1205677005934 PE family; Region: PE; pfam00934 1205677005935 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005936 PPE family; Region: PPE; pfam00823 1205677005937 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1205677005938 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1205677005939 active site 1205677005940 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1205677005941 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1205677005942 active site 1205677005943 Pup-like protein; Region: Pup; pfam05639 1205677005944 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1205677005945 proteasome ATPase; Region: pup_AAA; TIGR03689 1205677005946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677005947 Walker A motif; other site 1205677005948 ATP binding site [chemical binding]; other site 1205677005949 Walker B motif; other site 1205677005950 arginine finger; other site 1205677005951 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1205677005952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1205677005953 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1205677005954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677005955 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205677005956 Predicted membrane protein [Function unknown]; Region: COG3918 1205677005957 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1205677005958 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1205677005959 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1205677005960 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1205677005961 homodimer interface [polypeptide binding]; other site 1205677005962 putative metal binding site [ion binding]; other site 1205677005963 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677005964 PPE family; Region: PPE; pfam00823 1205677005965 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1205677005966 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1205677005967 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1205677005968 substrate binding pocket [chemical binding]; other site 1205677005969 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1205677005970 B12 binding site [chemical binding]; other site 1205677005971 cobalt ligand [ion binding]; other site 1205677005972 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1205677005973 PAC2 family; Region: PAC2; pfam09754 1205677005974 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205677005975 short chain dehydrogenase; Provisional; Region: PRK05872 1205677005976 classical (c) SDRs; Region: SDR_c; cd05233 1205677005977 NAD(P) binding site [chemical binding]; other site 1205677005978 active site 1205677005979 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205677005980 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1205677005981 active site 1205677005982 HIGH motif; other site 1205677005983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677005984 active site 1205677005985 KMSKS motif; other site 1205677005986 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1205677005987 putative tRNA binding surface [nucleotide binding]; other site 1205677005988 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1205677005989 active site 1205677005990 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677005991 conserved hypothetical protein; Region: TIGR03843 1205677005992 conserved hypothetical protein; Region: TIGR03847 1205677005993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677005994 catalytic core [active] 1205677005995 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1205677005996 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1205677005997 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1205677005998 quinone interaction residues [chemical binding]; other site 1205677005999 active site 1205677006000 catalytic residues [active] 1205677006001 FMN binding site [chemical binding]; other site 1205677006002 substrate binding site [chemical binding]; other site 1205677006003 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205677006004 substrate binding site [chemical binding]; other site 1205677006005 hypothetical protein; Provisional; Region: PRK07906 1205677006006 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1205677006007 putative metal binding site [ion binding]; other site 1205677006008 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1205677006009 Putative addiction module component; Region: Unstab_antitox; cl09921 1205677006010 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677006011 active site 1205677006012 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205677006013 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1205677006014 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205677006015 Predicted integral membrane protein [Function unknown]; Region: COG0762 1205677006016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1205677006017 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1205677006018 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205677006019 catalytic residue [active] 1205677006020 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1205677006021 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1205677006022 cell division protein FtsZ; Validated; Region: PRK09330 1205677006023 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1205677006024 nucleotide binding site [chemical binding]; other site 1205677006025 SulA interaction site; other site 1205677006026 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1205677006027 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1205677006028 Cell division protein FtsQ; Region: FtsQ; pfam03799 1205677006029 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1205677006030 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205677006031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205677006032 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205677006033 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1205677006034 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1205677006035 active site 1205677006036 homodimer interface [polypeptide binding]; other site 1205677006037 cell division protein FtsW; Region: ftsW; TIGR02614 1205677006038 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1205677006039 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205677006040 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205677006041 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1205677006042 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1205677006043 Mg++ binding site [ion binding]; other site 1205677006044 putative catalytic motif [active] 1205677006045 putative substrate binding site [chemical binding]; other site 1205677006046 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1205677006047 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205677006048 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205677006049 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1205677006050 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205677006051 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205677006052 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205677006053 PE family; Region: PE; pfam00934 1205677006054 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205677006055 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1205677006056 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205677006057 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1205677006058 MraW methylase family; Region: Methyltransf_5; pfam01795 1205677006059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1205677006060 MraZ protein; Region: MraZ; pfam02381 1205677006061 MraZ protein; Region: MraZ; pfam02381 1205677006062 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1205677006063 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1205677006064 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205677006065 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205677006066 substrate binding pocket [chemical binding]; other site 1205677006067 chain length determination region; other site 1205677006068 substrate-Mg2+ binding site; other site 1205677006069 catalytic residues [active] 1205677006070 aspartate-rich region 1; other site 1205677006071 active site lid residues [active] 1205677006072 aspartate-rich region 2; other site 1205677006073 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1205677006074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677006075 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677006076 active site 1205677006077 ATP binding site [chemical binding]; other site 1205677006078 substrate binding site [chemical binding]; other site 1205677006079 activation loop (A-loop); other site 1205677006080 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1205677006081 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1205677006082 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677006083 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205677006084 putative acyl-acceptor binding pocket; other site 1205677006085 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205677006086 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205677006087 DTAP/Switch II; other site 1205677006088 Switch I; other site 1205677006089 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205677006090 putative hydrophobic ligand binding site [chemical binding]; other site 1205677006091 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205677006092 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205677006093 acyl-activating enzyme (AAE) consensus motif; other site 1205677006094 putative AMP binding site [chemical binding]; other site 1205677006095 putative active site [active] 1205677006096 putative CoA binding site [chemical binding]; other site 1205677006097 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205677006098 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205677006099 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1205677006100 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205677006101 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205677006102 hypothetical protein; Validated; Region: PRK07883 1205677006103 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205677006104 active site 1205677006105 catalytic site [active] 1205677006106 substrate binding site [chemical binding]; other site 1205677006107 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205677006108 GIY-YIG motif/motif A; other site 1205677006109 active site 1205677006110 catalytic site [active] 1205677006111 putative DNA binding site [nucleotide binding]; other site 1205677006112 metal binding site [ion binding]; metal-binding site 1205677006113 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1205677006114 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205677006115 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205677006116 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1205677006117 Subunit I/III interface [polypeptide binding]; other site 1205677006118 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1205677006119 Cytochrome c; Region: Cytochrom_C; pfam00034 1205677006120 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1205677006121 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1205677006122 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1205677006123 iron-sulfur cluster [ion binding]; other site 1205677006124 [2Fe-2S] cluster binding site [ion binding]; other site 1205677006125 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1205677006126 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1205677006127 heme bH binding site [chemical binding]; other site 1205677006128 intrachain domain interface; other site 1205677006129 heme bL binding site [chemical binding]; other site 1205677006130 interchain domain interface [polypeptide binding]; other site 1205677006131 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1205677006132 Qo binding site; other site 1205677006133 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1205677006134 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205677006135 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1205677006136 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1205677006137 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1205677006138 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1205677006139 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1205677006140 dimer interface [polypeptide binding]; other site 1205677006141 active site 1205677006142 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1205677006143 Ligand Binding Site [chemical binding]; other site 1205677006144 Molecular Tunnel; other site 1205677006145 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1205677006146 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205677006147 substrate binding site [chemical binding]; other site 1205677006148 ATP binding site [chemical binding]; other site 1205677006149 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1205677006150 Glycerate kinase family; Region: Gly_kinase; cl00841 1205677006151 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1205677006152 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1205677006153 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1205677006154 putative dimer interface [polypeptide binding]; other site 1205677006155 active site pocket [active] 1205677006156 putative cataytic base [active] 1205677006157 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1205677006158 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1205677006159 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1205677006160 homodimer interface [polypeptide binding]; other site 1205677006161 substrate-cofactor binding pocket; other site 1205677006162 catalytic residue [active] 1205677006163 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1205677006164 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1205677006165 cyclase homology domain; Region: CHD; cd07302 1205677006166 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677006167 nucleotidyl binding site; other site 1205677006168 metal binding site [ion binding]; metal-binding site 1205677006169 dimer interface [polypeptide binding]; other site 1205677006170 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1205677006171 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1205677006172 interface (dimer of trimers) [polypeptide binding]; other site 1205677006173 Substrate-binding/catalytic site; other site 1205677006174 Zn-binding sites [ion binding]; other site 1205677006175 short chain dehydrogenase; Validated; Region: PRK05855 1205677006176 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205677006177 classical (c) SDRs; Region: SDR_c; cd05233 1205677006178 NAD(P) binding site [chemical binding]; other site 1205677006179 active site 1205677006180 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1205677006181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205677006182 E3 interaction surface; other site 1205677006183 lipoyl attachment site [posttranslational modification]; other site 1205677006184 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205677006185 E3 interaction surface; other site 1205677006186 lipoyl attachment site [posttranslational modification]; other site 1205677006187 e3 binding domain; Region: E3_binding; pfam02817 1205677006188 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205677006189 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1205677006190 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1205677006191 putative NAD(P) binding site [chemical binding]; other site 1205677006192 putative active site [active] 1205677006193 lipoate-protein ligase B; Provisional; Region: PRK14345 1205677006194 lipoyl synthase; Provisional; Region: PRK05481 1205677006195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677006196 FeS/SAM binding site; other site 1205677006197 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1205677006198 RDD family; Region: RDD; pfam06271 1205677006199 glutamine synthetase, type I; Region: GlnA; TIGR00653 1205677006200 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205677006201 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205677006202 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1205677006203 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205677006204 metal binding triad; other site 1205677006205 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205677006206 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205677006207 metal binding triad; other site 1205677006208 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205677006209 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205677006210 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205677006211 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205677006212 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205677006213 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205677006214 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205677006215 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205677006216 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1205677006217 oligomerization interface [polypeptide binding]; other site 1205677006218 active site 1205677006219 metal binding site [ion binding]; metal-binding site 1205677006220 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1205677006221 putative active site; other site 1205677006222 putative metal binding residues [ion binding]; other site 1205677006223 signature motif; other site 1205677006224 putative triphosphate binding site [ion binding]; other site 1205677006225 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1205677006226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1205677006227 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1205677006228 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1205677006229 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205677006230 active site 1205677006231 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677006232 catalytic core [active] 1205677006233 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1205677006234 Putative zinc ribbon domain; Region: DUF164; pfam02591 1205677006235 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1205677006236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1205677006237 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1205677006238 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1205677006239 hypothetical protein; Provisional; Region: PRK07908 1205677006240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677006241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677006242 homodimer interface [polypeptide binding]; other site 1205677006243 catalytic residue [active] 1205677006244 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1205677006245 putative active site [active] 1205677006246 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205677006247 Evidence 4 : Homologs of previously reported genes of unknown function 1205677006248 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1205677006249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677006250 active site 1205677006251 motif I; other site 1205677006252 motif II; other site 1205677006253 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205677006254 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1205677006255 active site 1205677006256 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1205677006257 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1205677006258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205677006259 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205677006260 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1205677006261 dimer interface [polypeptide binding]; other site 1205677006262 catalytic triad [active] 1205677006263 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1205677006264 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1205677006265 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1205677006266 dimer interface [polypeptide binding]; other site 1205677006267 TPP-binding site [chemical binding]; other site 1205677006268 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205677006269 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205677006270 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205677006271 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205677006272 acyl carrier protein; Provisional; Region: acpP; PRK00982 1205677006273 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1205677006274 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205677006275 dimer interface [polypeptide binding]; other site 1205677006276 active site 1205677006277 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1205677006278 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205677006279 dimer interface [polypeptide binding]; other site 1205677006280 active site 1205677006281 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205677006282 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205677006283 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205677006284 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 1205677006285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677006286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677006287 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677006288 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677006289 diacylglycerol kinase; Reviewed; Region: PRK11914 1205677006290 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205677006291 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1205677006292 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677006293 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677006294 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677006295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677006296 S-adenosylmethionine binding site [chemical binding]; other site 1205677006297 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1205677006298 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205677006299 NAD binding site [chemical binding]; other site 1205677006300 catalytic Zn binding site [ion binding]; other site 1205677006301 substrate binding site [chemical binding]; other site 1205677006302 structural Zn binding site [ion binding]; other site 1205677006303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205677006304 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1205677006305 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1205677006306 putative active site [active] 1205677006307 catalytic triad [active] 1205677006308 putative dimer interface [polypeptide binding]; other site 1205677006309 short chain dehydrogenase; Provisional; Region: PRK05854 1205677006310 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205677006311 putative NAD(P) binding site [chemical binding]; other site 1205677006312 active site 1205677006313 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205677006314 nucleotide binding site [chemical binding]; other site 1205677006315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205677006316 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677006317 Cytochrome P450; Region: p450; cl12078 1205677006318 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205677006319 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929527, 12657046; Product type pe : putative enzyme 1205677006320 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929527, 12657046; Product type pe : putative enzyme 1205677006321 Septum formation; Region: Septum_form; pfam13845 1205677006322 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1205677006323 Predicted membrane protein [Function unknown]; Region: COG2149 1205677006324 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1205677006325 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11929527, 15024109 1205677006326 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11929527, 15024109 1205677006327 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677006328 Cytochrome P450; Region: p450; cl12078 1205677006329 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1205677006330 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205677006331 putative active site [active] 1205677006332 catalytic site [active] 1205677006333 putative metal binding site [ion binding]; other site 1205677006334 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205677006335 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677006336 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205677006337 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205677006338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205677006339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205677006340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205677006341 dimerization interface [polypeptide binding]; other site 1205677006342 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677006343 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677006344 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677006345 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677006346 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677006347 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205677006348 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205677006349 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1205677006350 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1205677006351 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205677006352 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205677006353 active site residue [active] 1205677006354 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205677006355 active site residue [active] 1205677006356 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1205677006357 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1205677006358 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1205677006359 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677006360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677006361 homodimer interface [polypeptide binding]; other site 1205677006362 catalytic residue [active] 1205677006363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1205677006364 haloalkane dehalogenase; Provisional; Region: PRK00870 1205677006365 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205677006366 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205677006367 active site 1205677006368 catalytic tetrad [active] 1205677006369 heat shock protein 90; Provisional; Region: PRK05218 1205677006370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677006371 ATP binding site [chemical binding]; other site 1205677006372 Mg2+ binding site [ion binding]; other site 1205677006373 G-X-G motif; other site 1205677006374 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205677006375 Cutinase; Region: Cutinase; pfam01083 1205677006376 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205677006377 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205677006378 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1205677006379 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205677006380 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205677006381 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205677006382 Integrase core domain; Region: rve; pfam00665 1205677006383 Winged helix-turn helix; Region: HTH_29; pfam13551 1205677006384 Homeodomain-like domain; Region: HTH_32; pfam13565 1205677006385 Integrase core domain; Region: rve; pfam00665 1205677006386 Integrase core domain; Region: rve_3; pfam13683 1205677006387 Transposase; Region: HTH_Tnp_1; cl17663 1205677006388 putative transposase OrfB; Reviewed; Region: PHA02517 1205677006389 HTH-like domain; Region: HTH_21; pfam13276 1205677006390 Integrase core domain; Region: rve; pfam00665 1205677006391 Integrase core domain; Region: rve_3; cl15866 1205677006392 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1205677006393 Integrase core domain; Region: rve; pfam00665 1205677006394 Winged helix-turn helix; Region: HTH_29; pfam13551 1205677006395 Homeodomain-like domain; Region: HTH_32; pfam13565 1205677006396 Integrase core domain; Region: rve; pfam00665 1205677006397 Integrase core domain; Region: rve_3; pfam13683 1205677006398 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1205677006399 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1205677006400 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205677006401 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205677006402 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205677006403 MULE transposase domain; Region: MULE; pfam10551 1205677006404 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205677006405 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1205677006406 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1205677006407 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205677006408 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205677006409 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1205677006410 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1205677006411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677006412 putative PBP binding loops; other site 1205677006413 ABC-ATPase subunit interface; other site 1205677006414 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205677006415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677006416 dimer interface [polypeptide binding]; other site 1205677006417 conserved gate region; other site 1205677006418 putative PBP binding loops; other site 1205677006419 ABC-ATPase subunit interface; other site 1205677006420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205677006421 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205677006422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677006423 Ligand Binding Site [chemical binding]; other site 1205677006424 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677006425 Ligand Binding Site [chemical binding]; other site 1205677006426 amino acid transporter; Region: 2A0306; TIGR00909 1205677006427 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1205677006428 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1205677006429 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205677006430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677006431 catalytic residue [active] 1205677006432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205677006433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677006434 Amidinotransferase; Region: Amidinotransf; pfam02274 1205677006435 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1205677006436 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205677006437 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1205677006438 putative DNA binding site [nucleotide binding]; other site 1205677006439 putative Zn2+ binding site [ion binding]; other site 1205677006440 AsnC family; Region: AsnC_trans_reg; pfam01037 1205677006441 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1205677006442 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205677006443 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1205677006444 Walker A/P-loop; other site 1205677006445 ATP binding site [chemical binding]; other site 1205677006446 Q-loop/lid; other site 1205677006447 ABC transporter signature motif; other site 1205677006448 Walker B; other site 1205677006449 D-loop; other site 1205677006450 H-loop/switch region; other site 1205677006451 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205677006452 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205677006453 Walker A/P-loop; other site 1205677006454 ATP binding site [chemical binding]; other site 1205677006455 Q-loop/lid; other site 1205677006456 ABC transporter signature motif; other site 1205677006457 Walker B; other site 1205677006458 D-loop; other site 1205677006459 H-loop/switch region; other site 1205677006460 MarR family; Region: MarR; pfam01047 1205677006461 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205677006462 PE family; Region: PE; pfam00934 1205677006463 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205677006464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677006465 putative substrate translocation pore; other site 1205677006466 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205677006467 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205677006468 malate dehydrogenase; Provisional; Region: PRK13529 1205677006469 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1205677006470 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1205677006471 NAD(P) binding site [chemical binding]; other site 1205677006472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677006473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205677006474 putative substrate translocation pore; other site 1205677006475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677006476 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205677006477 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205677006478 dimer interface [polypeptide binding]; other site 1205677006479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677006480 catalytic residue [active] 1205677006481 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1205677006482 serine O-acetyltransferase; Region: cysE; TIGR01172 1205677006483 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1205677006484 trimer interface [polypeptide binding]; other site 1205677006485 active site 1205677006486 substrate binding site [chemical binding]; other site 1205677006487 CoA binding site [chemical binding]; other site 1205677006488 hypothetical protein; Provisional; Region: PRK14851 1205677006489 hypothetical protein; Validated; Region: PRK08223 1205677006490 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1205677006491 ATP binding site [chemical binding]; other site 1205677006492 substrate interface [chemical binding]; other site 1205677006493 Integrase core domain; Region: rve; pfam00665 1205677006494 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677006495 PE family; Region: PE; pfam00934 1205677006496 DNA primase; Validated; Region: dnaG; PRK05667 1205677006497 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1205677006498 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1205677006499 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1205677006500 active site 1205677006501 metal binding site [ion binding]; metal-binding site 1205677006502 interdomain interaction site; other site 1205677006503 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1205677006504 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1205677006505 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1205677006506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205677006507 Zn2+ binding site [ion binding]; other site 1205677006508 Mg2+ binding site [ion binding]; other site 1205677006509 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1205677006510 Repair protein; Region: Repair_PSII; pfam04536 1205677006511 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205677006512 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205677006513 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205677006514 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205677006515 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205677006516 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205677006517 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205677006518 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205677006519 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677006520 PPE family; Region: PPE; pfam00823 1205677006521 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1205677006522 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205677006523 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205677006524 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677006525 PPE family; Region: PPE; pfam00823 1205677006526 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677006527 PPE family; Region: PPE; pfam00823 1205677006528 PPE family; Region: PPE; pfam00823 1205677006529 PPE family; Region: PPE; pfam00823 1205677006530 PPE family; Region: PPE; pfam00823 1205677006531 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1205677006532 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205677006533 motif 1; other site 1205677006534 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1205677006535 dimer interface [polypeptide binding]; other site 1205677006536 active site 1205677006537 motif 2; other site 1205677006538 motif 3; other site 1205677006539 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1205677006540 anticodon binding site; other site 1205677006541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677006542 dimerization interface [polypeptide binding]; other site 1205677006543 putative DNA binding site [nucleotide binding]; other site 1205677006544 putative Zn2+ binding site [ion binding]; other site 1205677006545 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205677006546 metal binding site 2 [ion binding]; metal-binding site 1205677006547 putative DNA binding helix; other site 1205677006548 metal binding site 1 [ion binding]; metal-binding site 1205677006549 dimer interface [polypeptide binding]; other site 1205677006550 structural Zn2+ binding site [ion binding]; other site 1205677006551 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1205677006552 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1205677006553 catalytic residue [active] 1205677006554 putative FPP diphosphate binding site; other site 1205677006555 putative FPP binding hydrophobic cleft; other site 1205677006556 dimer interface [polypeptide binding]; other site 1205677006557 putative IPP diphosphate binding site; other site 1205677006558 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1205677006559 Recombination protein O N terminal; Region: RecO_N; pfam11967 1205677006560 Recombination protein O C terminal; Region: RecO_C; pfam02565 1205677006561 amidase; Provisional; Region: PRK06061 1205677006562 Amidase; Region: Amidase; pfam01425 1205677006563 GTPase Era; Reviewed; Region: era; PRK00089 1205677006564 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1205677006565 G1 box; other site 1205677006566 GTP/Mg2+ binding site [chemical binding]; other site 1205677006567 Switch I region; other site 1205677006568 G2 box; other site 1205677006569 Switch II region; other site 1205677006570 G3 box; other site 1205677006571 G4 box; other site 1205677006572 G5 box; other site 1205677006573 KH domain; Region: KH_2; pfam07650 1205677006574 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205677006575 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205677006576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205677006577 Transporter associated domain; Region: CorC_HlyC; smart01091 1205677006578 metal-binding heat shock protein; Provisional; Region: PRK00016 1205677006579 K homology RNA-binding domain; Region: KH; smart00322 1205677006580 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1205677006581 PhoH-like protein; Region: PhoH; pfam02562 1205677006582 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205677006583 PE family; Region: PE; pfam00934 1205677006584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1205677006585 RNA methyltransferase, RsmE family; Region: TIGR00046 1205677006586 chaperone protein DnaJ; Provisional; Region: PRK14278 1205677006587 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205677006588 HSP70 interaction site [polypeptide binding]; other site 1205677006589 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205677006590 Zn binding sites [ion binding]; other site 1205677006591 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205677006592 dimer interface [polypeptide binding]; other site 1205677006593 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1205677006594 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205677006595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1205677006596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677006597 Condensation domain; Region: Condensation; pfam00668 1205677006598 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205677006599 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205677006600 acyl-activating enzyme (AAE) consensus motif; other site 1205677006601 AMP binding site [chemical binding]; other site 1205677006602 Condensation domain; Region: Condensation; pfam00668 1205677006603 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205677006604 Condensation domain; Region: Condensation; pfam00668 1205677006605 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205677006606 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205677006607 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205677006608 acyl-activating enzyme (AAE) consensus motif; other site 1205677006609 AMP binding site [chemical binding]; other site 1205677006610 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205677006611 Condensation domain; Region: Condensation; pfam00668 1205677006612 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205677006613 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205677006614 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677006615 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205677006616 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205677006617 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677006618 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205677006619 NADP binding site [chemical binding]; other site 1205677006620 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205677006621 active site 1205677006622 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677006623 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677006624 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205677006625 active site 1205677006626 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1205677006627 Condensation domain; Region: Condensation; pfam00668 1205677006628 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205677006629 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1205677006630 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1205677006631 acyl-activating enzyme (AAE) consensus motif; other site 1205677006632 AMP binding site [chemical binding]; other site 1205677006633 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205677006634 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205677006635 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1205677006636 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1205677006637 acyl-activating enzyme (AAE) consensus motif; other site 1205677006638 active site 1205677006639 AMP binding site [chemical binding]; other site 1205677006640 substrate binding site [chemical binding]; other site 1205677006641 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205677006642 salicylate synthase MbtI; Reviewed; Region: PRK07912 1205677006643 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205677006644 Predicted permease [General function prediction only]; Region: COG3329 1205677006645 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1205677006646 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205677006647 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1205677006648 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205677006649 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205677006650 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1205677006651 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1205677006652 Active Sites [active] 1205677006653 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205677006654 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1205677006655 putative active site [active] 1205677006656 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1205677006657 putative active site [active] 1205677006658 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1205677006659 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1205677006660 Predicted membrane protein [Function unknown]; Region: COG1297 1205677006661 putative oligopeptide transporter, OPT family; Region: TIGR00733 1205677006662 PE family; Region: PE; pfam00934 1205677006663 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1205677006664 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1205677006665 Walker A/P-loop; other site 1205677006666 ATP binding site [chemical binding]; other site 1205677006667 Q-loop/lid; other site 1205677006668 ABC transporter signature motif; other site 1205677006669 Walker B; other site 1205677006670 D-loop; other site 1205677006671 H-loop/switch region; other site 1205677006672 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205677006673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677006674 dimer interface [polypeptide binding]; other site 1205677006675 conserved gate region; other site 1205677006676 putative PBP binding loops; other site 1205677006677 ABC-ATPase subunit interface; other site 1205677006678 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205677006679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677006680 dimer interface [polypeptide binding]; other site 1205677006681 conserved gate region; other site 1205677006682 putative PBP binding loops; other site 1205677006683 ABC-ATPase subunit interface; other site 1205677006684 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1205677006685 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1205677006686 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1205677006687 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1205677006688 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677006689 GTP-binding protein LepA; Provisional; Region: PRK05433 1205677006690 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1205677006691 G1 box; other site 1205677006692 putative GEF interaction site [polypeptide binding]; other site 1205677006693 GTP/Mg2+ binding site [chemical binding]; other site 1205677006694 Switch I region; other site 1205677006695 G2 box; other site 1205677006696 G3 box; other site 1205677006697 Switch II region; other site 1205677006698 G4 box; other site 1205677006699 G5 box; other site 1205677006700 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1205677006701 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1205677006702 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1205677006703 PemK-like protein; Region: PemK; pfam02452 1205677006704 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1205677006705 FOG: CBS domain [General function prediction only]; Region: COG0517 1205677006706 ribonuclease Z; Reviewed; Region: PRK00055 1205677006707 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205677006708 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205677006709 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205677006710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1205677006711 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1205677006712 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1205677006713 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1205677006714 hypothetical protein; Reviewed; Region: PRK07914 1205677006715 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1205677006716 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1205677006717 Competence protein; Region: Competence; pfam03772 1205677006718 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1205677006719 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205677006720 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1205677006721 DNA binding site [nucleotide binding] 1205677006722 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1205677006723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677006724 Coenzyme A binding pocket [chemical binding]; other site 1205677006725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1205677006726 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1205677006727 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1205677006728 active site 1205677006729 catalytic triad [active] 1205677006730 oxyanion hole [active] 1205677006731 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677006732 catalytic core [active] 1205677006733 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1205677006734 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1205677006735 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1205677006736 active site 1205677006737 (T/H)XGH motif; other site 1205677006738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677006739 S-adenosylmethionine binding site [chemical binding]; other site 1205677006740 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1205677006741 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205677006742 metal ion-dependent adhesion site (MIDAS); other site 1205677006743 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1205677006744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677006745 Walker A motif; other site 1205677006746 ATP binding site [chemical binding]; other site 1205677006747 Walker B motif; other site 1205677006748 arginine finger; other site 1205677006749 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1205677006750 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1205677006751 putative catalytic cysteine [active] 1205677006752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205677006753 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205677006754 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1205677006755 dimer interface [polypeptide binding]; other site 1205677006756 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1205677006757 catalytic triad [active] 1205677006758 peroxidatic and resolving cysteines [active] 1205677006759 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1205677006760 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1205677006761 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677006762 PPE family; Region: PPE; pfam00823 1205677006763 PE family; Region: PE; pfam00934 1205677006764 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1205677006765 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1205677006766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677006767 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677006768 ligand binding site [chemical binding]; other site 1205677006769 flexible hinge region; other site 1205677006770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677006771 dimerization interface [polypeptide binding]; other site 1205677006772 Heme NO binding associated; Region: HNOBA; pfam07701 1205677006773 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1205677006774 cyclase homology domain; Region: CHD; cd07302 1205677006775 nucleotidyl binding site; other site 1205677006776 metal binding site [ion binding]; metal-binding site 1205677006777 dimer interface [polypeptide binding]; other site 1205677006778 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205677006779 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1205677006780 substrate binding site [chemical binding]; other site 1205677006781 ATP binding site [chemical binding]; other site 1205677006782 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1205677006783 NAD synthetase; Reviewed; Region: nadE; PRK02628 1205677006784 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1205677006785 multimer interface [polypeptide binding]; other site 1205677006786 active site 1205677006787 catalytic triad [active] 1205677006788 protein interface 1 [polypeptide binding]; other site 1205677006789 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1205677006790 homodimer interface [polypeptide binding]; other site 1205677006791 NAD binding pocket [chemical binding]; other site 1205677006792 ATP binding pocket [chemical binding]; other site 1205677006793 Mg binding site [ion binding]; other site 1205677006794 active-site loop [active] 1205677006795 gamma-glutamyl kinase; Provisional; Region: PRK05429 1205677006796 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1205677006797 nucleotide binding site [chemical binding]; other site 1205677006798 homotetrameric interface [polypeptide binding]; other site 1205677006799 putative phosphate binding site [ion binding]; other site 1205677006800 putative allosteric binding site; other site 1205677006801 PUA domain; Region: PUA; pfam01472 1205677006802 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1205677006803 GTP1/OBG; Region: GTP1_OBG; pfam01018 1205677006804 Obg GTPase; Region: Obg; cd01898 1205677006805 G1 box; other site 1205677006806 GTP/Mg2+ binding site [chemical binding]; other site 1205677006807 Switch I region; other site 1205677006808 G2 box; other site 1205677006809 G3 box; other site 1205677006810 Switch II region; other site 1205677006811 G4 box; other site 1205677006812 G5 box; other site 1205677006813 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1205677006814 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1205677006815 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1205677006816 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1205677006817 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1205677006818 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1205677006819 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1205677006820 homodimer interface [polypeptide binding]; other site 1205677006821 oligonucleotide binding site [chemical binding]; other site 1205677006822 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1205677006823 active site 1205677006824 multimer interface [polypeptide binding]; other site 1205677006825 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1205677006826 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1205677006827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205677006828 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1205677006829 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677006830 active site 1205677006831 HIGH motif; other site 1205677006832 nucleotide binding site [chemical binding]; other site 1205677006833 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1205677006834 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1205677006835 active site 1205677006836 KMSKS motif; other site 1205677006837 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1205677006838 tRNA binding surface [nucleotide binding]; other site 1205677006839 anticodon binding site; other site 1205677006840 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1205677006841 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1205677006842 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1205677006843 NAD(P) binding pocket [chemical binding]; other site 1205677006844 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205677006845 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1205677006846 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677006847 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1205677006848 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1205677006849 GTP binding site; other site 1205677006850 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1205677006851 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1205677006852 TPP-binding site [chemical binding]; other site 1205677006853 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1205677006854 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1205677006855 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1205677006856 dimer interface [polypeptide binding]; other site 1205677006857 PYR/PP interface [polypeptide binding]; other site 1205677006858 TPP binding site [chemical binding]; other site 1205677006859 substrate binding site [chemical binding]; other site 1205677006860 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1205677006861 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1205677006862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677006863 Walker A motif; other site 1205677006864 ATP binding site [chemical binding]; other site 1205677006865 Walker B motif; other site 1205677006866 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1205677006867 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1205677006868 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1205677006869 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1205677006870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677006871 putative substrate translocation pore; other site 1205677006872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677006873 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1205677006874 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205677006875 oligomer interface [polypeptide binding]; other site 1205677006876 active site residues [active] 1205677006877 Clp protease; Region: CLP_protease; pfam00574 1205677006878 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205677006879 oligomer interface [polypeptide binding]; other site 1205677006880 active site residues [active] 1205677006881 trigger factor; Provisional; Region: tig; PRK01490 1205677006882 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1205677006883 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1205677006884 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677006885 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677006886 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205677006887 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1205677006888 putative DNA binding site [nucleotide binding]; other site 1205677006889 catalytic residue [active] 1205677006890 putative H2TH interface [polypeptide binding]; other site 1205677006891 putative catalytic residues [active] 1205677006892 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205677006893 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205677006894 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1205677006895 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205677006896 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205677006897 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1205677006898 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1205677006899 Zn binding site [ion binding]; other site 1205677006900 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1205677006901 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677006902 active site 1205677006903 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1205677006904 apolar tunnel; other site 1205677006905 heme binding site [chemical binding]; other site 1205677006906 dimerization interface [polypeptide binding]; other site 1205677006907 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1205677006908 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1205677006909 active site 1205677006910 catalytic site [active] 1205677006911 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1205677006912 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1205677006913 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205677006914 active site 1205677006915 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1205677006916 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1205677006917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205677006918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205677006919 ABC transporter; Region: ABC_tran_2; pfam12848 1205677006920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205677006921 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1205677006922 dimer interface [polypeptide binding]; other site 1205677006923 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1205677006924 ssDNA binding site [nucleotide binding]; other site 1205677006925 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1205677006926 Evidence 5 : No homology to any previously reported sequences 1205677006927 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1205677006928 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1205677006929 putative acyl-acceptor binding pocket; other site 1205677006930 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205677006931 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1205677006932 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677006933 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205677006934 putative acyl-acceptor binding pocket; other site 1205677006935 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677006936 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677006937 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205677006938 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677006939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677006940 enoyl-CoA hydratase; Provisional; Region: PRK05870 1205677006941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677006942 substrate binding site [chemical binding]; other site 1205677006943 oxyanion hole (OAH) forming residues; other site 1205677006944 trimer interface [polypeptide binding]; other site 1205677006945 PE family; Region: PE; pfam00934 1205677006946 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677006947 cyclase homology domain; Region: CHD; cd07302 1205677006948 nucleotidyl binding site; other site 1205677006949 metal binding site [ion binding]; metal-binding site 1205677006950 dimer interface [polypeptide binding]; other site 1205677006951 Predicted ATPase [General function prediction only]; Region: COG3903 1205677006952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677006953 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677006954 DNA binding residues [nucleotide binding] 1205677006955 dimerization interface [polypeptide binding]; other site 1205677006956 PE family; Region: PE; pfam00934 1205677006957 TIGR00725 family protein; Region: TIGR00725 1205677006958 thymidylate synthase; Provisional; Region: thyA; PRK00956 1205677006959 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205677006960 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1205677006961 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205677006962 E3 interaction surface; other site 1205677006963 lipoyl attachment site [posttranslational modification]; other site 1205677006964 e3 binding domain; Region: E3_binding; pfam02817 1205677006965 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205677006966 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1205677006967 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1205677006968 alpha subunit interface [polypeptide binding]; other site 1205677006969 TPP binding site [chemical binding]; other site 1205677006970 heterodimer interface [polypeptide binding]; other site 1205677006971 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205677006972 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1205677006973 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205677006974 tetramer interface [polypeptide binding]; other site 1205677006975 TPP-binding site [chemical binding]; other site 1205677006976 heterodimer interface [polypeptide binding]; other site 1205677006977 phosphorylation loop region [posttranslational modification] 1205677006978 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205677006979 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1205677006980 putative active site [active] 1205677006981 putative catalytic site [active] 1205677006982 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677006983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677006984 active site 1205677006985 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205677006986 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205677006987 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1205677006988 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205677006989 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205677006990 carboxyltransferase (CT) interaction site; other site 1205677006991 biotinylation site [posttranslational modification]; other site 1205677006992 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205677006993 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205677006994 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205677006995 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1205677006996 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1205677006997 AMP-binding domain protein; Validated; Region: PRK08315 1205677006998 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677006999 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1205677007000 acyl-activating enzyme (AAE) consensus motif; other site 1205677007001 acyl-activating enzyme (AAE) consensus motif; other site 1205677007002 putative AMP binding site [chemical binding]; other site 1205677007003 putative active site [active] 1205677007004 putative CoA binding site [chemical binding]; other site 1205677007005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677007006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677007007 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1205677007008 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205677007009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677007010 NAD(P) binding site [chemical binding]; other site 1205677007011 active site 1205677007012 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1205677007013 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1205677007014 catalytic site [active] 1205677007015 putative active site [active] 1205677007016 putative substrate binding site [chemical binding]; other site 1205677007017 dimer interface [polypeptide binding]; other site 1205677007018 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1205677007019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677007020 non-specific DNA binding site [nucleotide binding]; other site 1205677007021 salt bridge; other site 1205677007022 sequence-specific DNA binding site [nucleotide binding]; other site 1205677007023 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1205677007024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1205677007025 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205677007026 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205677007027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205677007028 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205677007029 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1205677007030 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1205677007031 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205677007032 catalytic triad [active] 1205677007033 hypothetical protein; Provisional; Region: PRK07907 1205677007034 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1205677007035 active site 1205677007036 metal binding site [ion binding]; metal-binding site 1205677007037 dimer interface [polypeptide binding]; other site 1205677007038 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1205677007039 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205677007040 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1205677007041 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205677007042 phosphate binding site [ion binding]; other site 1205677007043 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1205677007044 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1205677007045 putative active site [active] 1205677007046 putative catalytic site [active] 1205677007047 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205677007048 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205677007049 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1205677007050 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1205677007051 putative NAD(P) binding site [chemical binding]; other site 1205677007052 active site 1205677007053 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1205677007054 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1205677007055 active site 1205677007056 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1205677007057 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677007058 putative active site [active] 1205677007059 ERCC4 domain; Region: ERCC4; pfam02732 1205677007060 Lsr2; Region: Lsr2; pfam11774 1205677007061 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1205677007062 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205677007063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677007064 catalytic residue [active] 1205677007065 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1205677007066 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1205677007067 putative RNA binding site [nucleotide binding]; other site 1205677007068 elongation factor P; Validated; Region: PRK00529 1205677007069 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1205677007070 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1205677007071 RNA binding site [nucleotide binding]; other site 1205677007072 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1205677007073 RNA binding site [nucleotide binding]; other site 1205677007074 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1205677007075 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1205677007076 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1205677007077 active site 1205677007078 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1205677007079 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1205677007080 trimer interface [polypeptide binding]; other site 1205677007081 active site 1205677007082 dimer interface [polypeptide binding]; other site 1205677007083 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1205677007084 active site 1205677007085 dimer interface [polypeptide binding]; other site 1205677007086 metal binding site [ion binding]; metal-binding site 1205677007087 shikimate kinase; Reviewed; Region: aroK; PRK00131 1205677007088 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1205677007089 ADP binding site [chemical binding]; other site 1205677007090 magnesium binding site [ion binding]; other site 1205677007091 putative shikimate binding site; other site 1205677007092 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1205677007093 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1205677007094 Tetramer interface [polypeptide binding]; other site 1205677007095 active site 1205677007096 FMN-binding site [chemical binding]; other site 1205677007097 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205677007098 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677007099 putative active site [active] 1205677007100 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677007101 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205677007102 oligomeric interface; other site 1205677007103 putative active site [active] 1205677007104 homodimer interface [polypeptide binding]; other site 1205677007105 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1205677007106 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677007107 Integrase core domain; Region: rve; pfam00665 1205677007108 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1205677007109 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1205677007110 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1205677007111 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1205677007112 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1205677007113 NAD(P) binding site [chemical binding]; other site 1205677007114 shikimate binding site; other site 1205677007115 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1205677007116 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1205677007117 dimerization interface [polypeptide binding]; other site 1205677007118 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1205677007119 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1205677007120 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1205677007121 motif 1; other site 1205677007122 active site 1205677007123 motif 2; other site 1205677007124 motif 3; other site 1205677007125 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1205677007126 DHHA1 domain; Region: DHHA1; pfam02272 1205677007127 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1205677007128 recombination factor protein RarA; Reviewed; Region: PRK13342 1205677007129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677007130 Walker A motif; other site 1205677007131 ATP binding site [chemical binding]; other site 1205677007132 Walker B motif; other site 1205677007133 arginine finger; other site 1205677007134 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1205677007135 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1205677007136 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1205677007137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205677007138 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205677007139 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205677007140 Walker A/P-loop; other site 1205677007141 ATP binding site [chemical binding]; other site 1205677007142 Q-loop/lid; other site 1205677007143 ABC transporter signature motif; other site 1205677007144 Walker B; other site 1205677007145 D-loop; other site 1205677007146 H-loop/switch region; other site 1205677007147 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677007148 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677007149 ligand binding site [chemical binding]; other site 1205677007150 flexible hinge region; other site 1205677007151 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677007152 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677007153 ligand binding site [chemical binding]; other site 1205677007154 flexible hinge region; other site 1205677007155 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205677007156 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1205677007157 active site 1205677007158 nucleophile elbow; other site 1205677007159 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205677007160 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205677007161 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205677007162 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1205677007163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1205677007164 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1205677007165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1205677007166 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1205677007167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1205677007168 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1205677007169 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205677007170 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205677007171 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1205677007172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1205677007173 Predicted membrane protein [Function unknown]; Region: COG4129 1205677007174 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1205677007175 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1205677007176 dimer interface [polypeptide binding]; other site 1205677007177 anticodon binding site; other site 1205677007178 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1205677007179 homodimer interface [polypeptide binding]; other site 1205677007180 motif 1; other site 1205677007181 active site 1205677007182 motif 2; other site 1205677007183 GAD domain; Region: GAD; pfam02938 1205677007184 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205677007185 active site 1205677007186 motif 3; other site 1205677007187 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1205677007188 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1205677007189 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1205677007190 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205677007191 putative hydrophobic ligand binding site [chemical binding]; other site 1205677007192 protein interface [polypeptide binding]; other site 1205677007193 gate; other site 1205677007194 Predicted metalloprotease [General function prediction only]; Region: COG2321 1205677007195 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1205677007196 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205677007197 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205677007198 active site 1205677007199 metal binding site [ion binding]; metal-binding site 1205677007200 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1205677007201 haloalkane dehalogenase; Provisional; Region: PRK03592 1205677007202 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1205677007203 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1205677007204 motif 1; other site 1205677007205 dimer interface [polypeptide binding]; other site 1205677007206 active site 1205677007207 motif 2; other site 1205677007208 motif 3; other site 1205677007209 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1205677007210 anticodon binding site; other site 1205677007211 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205677007212 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205677007213 active site 1205677007214 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1205677007215 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205677007216 Zn2+ binding site [ion binding]; other site 1205677007217 Mg2+ binding site [ion binding]; other site 1205677007218 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205677007219 synthetase active site [active] 1205677007220 NTP binding site [chemical binding]; other site 1205677007221 metal binding site [ion binding]; metal-binding site 1205677007222 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1205677007223 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1205677007224 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677007225 active site 1205677007226 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1205677007227 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205677007228 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1205677007229 Protein export membrane protein; Region: SecD_SecF; pfam02355 1205677007230 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1205677007231 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1205677007232 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1205677007233 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1205677007234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205677007235 inhibitor-cofactor binding pocket; inhibition site 1205677007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677007237 catalytic residue [active] 1205677007238 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205677007239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677007240 acyl-activating enzyme (AAE) consensus motif; other site 1205677007241 AMP binding site [chemical binding]; other site 1205677007242 active site 1205677007243 CoA binding site [chemical binding]; other site 1205677007244 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1205677007245 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1205677007246 putative NAD(P) binding site [chemical binding]; other site 1205677007247 active site 1205677007248 putative substrate binding site [chemical binding]; other site 1205677007249 PE family; Region: PE; pfam00934 1205677007250 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1205677007251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677007252 Walker A motif; other site 1205677007253 ATP binding site [chemical binding]; other site 1205677007254 Walker B motif; other site 1205677007255 arginine finger; other site 1205677007256 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1205677007257 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1205677007258 RuvA N terminal domain; Region: RuvA_N; pfam01330 1205677007259 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1205677007260 active site 1205677007261 putative DNA-binding cleft [nucleotide binding]; other site 1205677007262 dimer interface [polypeptide binding]; other site 1205677007263 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1205677007264 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1205677007265 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205677007266 putative active site [active] 1205677007267 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1205677007268 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1205677007269 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1205677007270 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1205677007271 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1205677007272 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1205677007273 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1205677007274 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205677007275 hypothetical protein; Validated; Region: PRK00110 1205677007276 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1205677007277 predicted active site [active] 1205677007278 catalytic triad [active] 1205677007279 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1205677007280 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205677007281 active site 1205677007282 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1205677007283 catalytic triad [active] 1205677007284 dimer interface [polypeptide binding]; other site 1205677007285 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1205677007286 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1205677007287 active site 1205677007288 multimer interface [polypeptide binding]; other site 1205677007289 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1205677007290 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205677007291 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1205677007292 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677007293 PPE family; Region: PPE; pfam00823 1205677007294 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677007295 PE-PPE domain; Region: PE-PPE; pfam08237 1205677007296 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1205677007297 nudix motif; other site 1205677007298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205677007299 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205677007300 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1205677007301 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1205677007302 putative acyl-acceptor binding pocket; other site 1205677007303 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205677007304 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1205677007305 nucleotide binding site/active site [active] 1205677007306 HIT family signature motif; other site 1205677007307 catalytic residue [active] 1205677007308 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1205677007309 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1205677007310 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1205677007311 active site 1205677007312 dimer interface [polypeptide binding]; other site 1205677007313 motif 1; other site 1205677007314 motif 2; other site 1205677007315 motif 3; other site 1205677007316 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1205677007317 anticodon binding site; other site 1205677007318 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 1205677007319 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205677007320 Helix-turn-helix domain; Region: HTH_20; pfam12840 1205677007321 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1205677007322 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205677007323 Helix-turn-helix domain; Region: HTH_20; pfam12840 1205677007324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677007325 S-adenosylmethionine binding site [chemical binding]; other site 1205677007326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677007327 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677007328 Ligand Binding Site [chemical binding]; other site 1205677007329 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677007330 Ligand Binding Site [chemical binding]; other site 1205677007331 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677007332 Ligand Binding Site [chemical binding]; other site 1205677007333 Universal stress protein family; Region: Usp; pfam00582 1205677007334 Ligand Binding Site [chemical binding]; other site 1205677007335 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1205677007336 active site 1205677007337 Peptidase family M50; Region: Peptidase_M50; pfam02163 1205677007338 putative substrate binding region [chemical binding]; other site 1205677007339 FOG: CBS domain [General function prediction only]; Region: COG0517 1205677007340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1205677007341 FOG: CBS domain [General function prediction only]; Region: COG0517 1205677007342 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1205677007343 peptide chain release factor 1; Provisional; Region: PRK04011 1205677007344 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1205677007345 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1205677007346 hypothetical protein; Reviewed; Region: PRK09588 1205677007347 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1205677007348 Hemerythrin-like domain; Region: Hr-like; cd12108 1205677007349 Fe binding site [ion binding]; other site 1205677007350 PE family; Region: PE; pfam00934 1205677007351 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1205677007352 P-loop motif; other site 1205677007353 ATP binding site [chemical binding]; other site 1205677007354 Chloramphenicol (Cm) binding site [chemical binding]; other site 1205677007355 catalytic residue [active] 1205677007356 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1205677007357 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1205677007358 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205677007359 anti sigma factor interaction site; other site 1205677007360 regulatory phosphorylation site [posttranslational modification]; other site 1205677007361 hypothetical protein; Provisional; Region: PRK02237 1205677007362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677007363 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205677007364 putative DNA binding site [nucleotide binding]; other site 1205677007365 putative Zn2+ binding site [ion binding]; other site 1205677007366 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1205677007367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205677007368 putative metal binding site [ion binding]; other site 1205677007369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677007370 dimerization interface [polypeptide binding]; other site 1205677007371 putative DNA binding site [nucleotide binding]; other site 1205677007372 putative Zn2+ binding site [ion binding]; other site 1205677007373 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1205677007374 arsenical-resistance protein; Region: acr3; TIGR00832 1205677007375 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1205677007376 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205677007377 active site 1205677007378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205677007379 active site 1205677007380 Int/Topo IB signature motif; other site 1205677007381 DNA binding site [nucleotide binding] 1205677007382 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677007383 Clp protease ATP binding subunit; Region: clpC; CHL00095 1205677007384 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1205677007385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677007386 Coenzyme A binding pocket [chemical binding]; other site 1205677007387 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1205677007388 hypothetical protein; Provisional; Region: PRK14059 1205677007389 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1205677007390 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677007391 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205677007392 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1205677007393 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1205677007394 SelR domain; Region: SelR; pfam01641 1205677007395 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677007396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677007397 S-adenosylmethionine binding site [chemical binding]; other site 1205677007398 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1205677007399 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1205677007400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677007401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677007402 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1205677007403 substrate binding site [chemical binding]; other site 1205677007404 active site 1205677007405 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677007406 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205677007407 substrate binding site [chemical binding]; other site 1205677007408 oxyanion hole (OAH) forming residues; other site 1205677007409 trimer interface [polypeptide binding]; other site 1205677007410 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1205677007411 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1205677007412 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1205677007413 catalytic site [active] 1205677007414 putative active site [active] 1205677007415 putative substrate binding site [chemical binding]; other site 1205677007416 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1205677007417 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1205677007418 TPP-binding site; other site 1205677007419 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205677007420 PYR/PP interface [polypeptide binding]; other site 1205677007421 dimer interface [polypeptide binding]; other site 1205677007422 TPP binding site [chemical binding]; other site 1205677007423 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205677007424 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205677007425 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205677007426 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1205677007427 transmembrane helices; other site 1205677007428 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205677007429 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1205677007430 transmembrane helices; other site 1205677007431 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205677007432 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205677007433 Walker A/P-loop; other site 1205677007434 ATP binding site [chemical binding]; other site 1205677007435 Q-loop/lid; other site 1205677007436 ABC transporter signature motif; other site 1205677007437 Walker B; other site 1205677007438 D-loop; other site 1205677007439 H-loop/switch region; other site 1205677007440 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205677007441 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205677007442 TrkA-N domain; Region: TrkA_N; pfam02254 1205677007443 TrkA-C domain; Region: TrkA_C; pfam02080 1205677007444 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205677007445 TrkA-N domain; Region: TrkA_N; pfam02254 1205677007446 TrkA-C domain; Region: TrkA_C; pfam02080 1205677007447 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1205677007448 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1205677007449 generic binding surface II; other site 1205677007450 ssDNA binding site; other site 1205677007451 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1205677007452 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205677007453 trimer interface [polypeptide binding]; other site 1205677007454 active site 1205677007455 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1205677007456 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1205677007457 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205677007458 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205677007459 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1205677007460 active site 1205677007461 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205677007462 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205677007463 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205677007464 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677007465 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205677007466 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677007467 DNA binding residues [nucleotide binding] 1205677007468 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1205677007469 homotrimer interaction site [polypeptide binding]; other site 1205677007470 putative active site [active] 1205677007471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1205677007472 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1205677007473 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1205677007474 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1205677007475 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205677007476 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1205677007477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677007478 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205677007479 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677007480 DNA binding residues [nucleotide binding] 1205677007481 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1205677007482 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1205677007483 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205677007484 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1205677007485 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1205677007486 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1205677007487 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677007488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677007489 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205677007490 PAC2 family; Region: PAC2; pfam09754 1205677007491 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677007492 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1205677007493 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1205677007494 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1205677007495 heme-binding site [chemical binding]; other site 1205677007496 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1205677007497 ATP cone domain; Region: ATP-cone; pfam03477 1205677007498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1205677007499 LexA repressor; Validated; Region: PRK00215 1205677007500 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1205677007501 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1205677007502 Catalytic site [active] 1205677007503 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1205677007504 LGFP repeat; Region: LGFP; pfam08310 1205677007505 LGFP repeat; Region: LGFP; pfam08310 1205677007506 LGFP repeat; Region: LGFP; pfam08310 1205677007507 LGFP repeat; Region: LGFP; pfam08310 1205677007508 LGFP repeat; Region: LGFP; pfam08310 1205677007509 Integral membrane protein TerC family; Region: TerC; cl10468 1205677007510 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677007511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677007512 active site 1205677007513 GTPases [General function prediction only]; Region: HflX; COG2262 1205677007514 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1205677007515 HflX GTPase family; Region: HflX; cd01878 1205677007516 G1 box; other site 1205677007517 GTP/Mg2+ binding site [chemical binding]; other site 1205677007518 Switch I region; other site 1205677007519 G2 box; other site 1205677007520 G3 box; other site 1205677007521 Switch II region; other site 1205677007522 G4 box; other site 1205677007523 G5 box; other site 1205677007524 diaminopimelate epimerase; Region: DapF; TIGR00652 1205677007525 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205677007526 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205677007527 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1205677007528 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1205677007529 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1205677007530 active site 1205677007531 metal binding site [ion binding]; metal-binding site 1205677007532 Evidence 4 : Homologs of previously reported genes of unknown function 1205677007533 Evidence 4 : Homologs of previously reported genes of unknown function 1205677007534 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205677007535 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205677007536 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205677007537 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1205677007538 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1205677007539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677007540 FeS/SAM binding site; other site 1205677007541 TRAM domain; Region: TRAM; cl01282 1205677007542 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1205677007543 recA bacterial DNA recombination protein; Region: RecA; cl17211 1205677007544 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205677007545 thioester formation/cholesterol transfer; other site 1205677007546 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 1205677007547 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 1205677007548 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1205677007549 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205677007550 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1205677007551 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1205677007552 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1205677007553 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205677007554 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205677007555 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1205677007556 PE family; Region: PE; pfam00934 1205677007557 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1205677007558 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1205677007559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677007560 non-specific DNA binding site [nucleotide binding]; other site 1205677007561 salt bridge; other site 1205677007562 sequence-specific DNA binding site [nucleotide binding]; other site 1205677007563 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205677007564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677007565 Coenzyme A binding pocket [chemical binding]; other site 1205677007566 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1205677007567 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677007568 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1205677007569 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205677007570 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1205677007571 classical (c) SDRs; Region: SDR_c; cd05233 1205677007572 NAD(P) binding site [chemical binding]; other site 1205677007573 active site 1205677007574 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677007575 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677007576 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1205677007577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205677007578 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1205677007579 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1205677007580 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1205677007581 dimer interface [polypeptide binding]; other site 1205677007582 active site 1205677007583 catalytic residue [active] 1205677007584 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1205677007585 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1205677007586 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1205677007587 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1205677007588 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205677007589 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677007590 putative active site [active] 1205677007591 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205677007592 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205677007593 putative active site [active] 1205677007594 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1205677007595 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1205677007596 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1205677007597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1205677007598 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1205677007599 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1205677007600 folate binding site [chemical binding]; other site 1205677007601 NADP+ binding site [chemical binding]; other site 1205677007602 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1205677007603 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1205677007604 dimerization interface [polypeptide binding]; other site 1205677007605 active site 1205677007606 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205677007607 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205677007608 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1205677007609 classical (c) SDRs; Region: SDR_c; cd05233 1205677007610 NAD(P) binding site [chemical binding]; other site 1205677007611 active site 1205677007612 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677007613 PPE family; Region: PPE; pfam00823 1205677007614 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677007615 PE family; Region: PE; pfam00934 1205677007616 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677007617 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677007618 PPE family; Region: PPE; pfam00823 1205677007619 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677007620 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1205677007621 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1205677007622 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1205677007623 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1205677007624 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1205677007625 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1205677007626 putative active site [active] 1205677007627 putative NTP binding site [chemical binding]; other site 1205677007628 putative nucleic acid binding site [nucleotide binding]; other site 1205677007629 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1205677007630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205677007631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677007632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205677007633 Coenzyme A binding pocket [chemical binding]; other site 1205677007634 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205677007635 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1205677007636 FMN-binding pocket [chemical binding]; other site 1205677007637 flavin binding motif; other site 1205677007638 phosphate binding motif [ion binding]; other site 1205677007639 beta-alpha-beta structure motif; other site 1205677007640 NAD binding pocket [chemical binding]; other site 1205677007641 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677007642 catalytic loop [active] 1205677007643 iron binding site [ion binding]; other site 1205677007644 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1205677007645 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1205677007646 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205677007647 hydrophobic ligand binding site; other site 1205677007648 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205677007649 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677007650 putative DNA binding site [nucleotide binding]; other site 1205677007651 putative Zn2+ binding site [ion binding]; other site 1205677007652 AsnC family; Region: AsnC_trans_reg; pfam01037 1205677007653 alanine dehydrogenase; Region: alaDH; TIGR00518 1205677007654 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1205677007655 hexamer interface [polypeptide binding]; other site 1205677007656 ligand binding site [chemical binding]; other site 1205677007657 putative active site [active] 1205677007658 NAD(P) binding site [chemical binding]; other site 1205677007659 Nitronate monooxygenase; Region: NMO; pfam03060 1205677007660 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205677007661 FMN binding site [chemical binding]; other site 1205677007662 substrate binding site [chemical binding]; other site 1205677007663 putative catalytic residue [active] 1205677007664 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1205677007665 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1205677007666 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1205677007667 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1205677007668 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1205677007669 oligomer interface [polypeptide binding]; other site 1205677007670 RNA binding site [nucleotide binding]; other site 1205677007671 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1205677007672 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1205677007673 RNase E interface [polypeptide binding]; other site 1205677007674 trimer interface [polypeptide binding]; other site 1205677007675 active site 1205677007676 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1205677007677 putative nucleic acid binding region [nucleotide binding]; other site 1205677007678 G-X-X-G motif; other site 1205677007679 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1205677007680 RNA binding site [nucleotide binding]; other site 1205677007681 domain interface; other site 1205677007682 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1205677007683 16S/18S rRNA binding site [nucleotide binding]; other site 1205677007684 S13e-L30e interaction site [polypeptide binding]; other site 1205677007685 25S rRNA binding site [nucleotide binding]; other site 1205677007686 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1205677007687 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1205677007688 active site 1205677007689 Riboflavin kinase; Region: Flavokinase; pfam01687 1205677007690 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205677007691 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1205677007692 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1205677007693 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677007694 putative DNA binding site [nucleotide binding]; other site 1205677007695 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205677007696 FeoA domain; Region: FeoA; pfam04023 1205677007697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677007698 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677007699 active site 1205677007700 lipid-transfer protein; Provisional; Region: PRK08256 1205677007701 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205677007702 active site 1205677007703 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1205677007704 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1205677007705 RNA binding site [nucleotide binding]; other site 1205677007706 active site 1205677007707 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1205677007708 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1205677007709 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1205677007710 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205677007711 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205677007712 active site 1205677007713 metal binding site [ion binding]; metal-binding site 1205677007714 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1205677007715 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205677007716 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205677007717 Predicted acyl esterases [General function prediction only]; Region: COG2936 1205677007718 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1205677007719 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205677007720 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1205677007721 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1205677007722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1205677007723 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205677007724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205677007725 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677007726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205677007727 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677007728 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1205677007729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205677007730 Integrase core domain; Region: rve; pfam00665 1205677007731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1205677007732 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1205677007733 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1205677007734 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1205677007735 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1205677007736 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1205677007737 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 1205677007738 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 1205677007739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205677007740 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1205677007741 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1205677007742 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1205677007743 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1205677007744 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1205677007745 putative active site [active] 1205677007746 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205677007747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677007748 substrate binding site [chemical binding]; other site 1205677007749 oxyanion hole (OAH) forming residues; other site 1205677007750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1205677007751 oxyanion hole (OAH) forming residues; other site 1205677007752 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205677007753 Probable transposase; Region: OrfB_IS605; pfam01385 1205677007754 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1205677007755 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1205677007756 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205677007757 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205677007758 Walker A/P-loop; other site 1205677007759 ATP binding site [chemical binding]; other site 1205677007760 Q-loop/lid; other site 1205677007761 ABC transporter signature motif; other site 1205677007762 Walker B; other site 1205677007763 D-loop; other site 1205677007764 H-loop/switch region; other site 1205677007765 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205677007766 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205677007767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205677007768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677007769 dimer interface [polypeptide binding]; other site 1205677007770 conserved gate region; other site 1205677007771 putative PBP binding loops; other site 1205677007772 ABC-ATPase subunit interface; other site 1205677007773 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1205677007774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677007775 dimer interface [polypeptide binding]; other site 1205677007776 conserved gate region; other site 1205677007777 putative PBP binding loops; other site 1205677007778 ABC-ATPase subunit interface; other site 1205677007779 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1205677007780 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1205677007781 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1205677007782 DHH family; Region: DHH; pfam01368 1205677007783 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1205677007784 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1205677007785 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1205677007786 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1205677007787 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1205677007788 G1 box; other site 1205677007789 putative GEF interaction site [polypeptide binding]; other site 1205677007790 GTP/Mg2+ binding site [chemical binding]; other site 1205677007791 Switch I region; other site 1205677007792 G2 box; other site 1205677007793 G3 box; other site 1205677007794 Switch II region; other site 1205677007795 G4 box; other site 1205677007796 G5 box; other site 1205677007797 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1205677007798 Translation-initiation factor 2; Region: IF-2; pfam11987 1205677007799 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1205677007800 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1205677007801 putative RNA binding cleft [nucleotide binding]; other site 1205677007802 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1205677007803 NusA N-terminal domain; Region: NusA_N; pfam08529 1205677007804 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1205677007805 RNA binding site [nucleotide binding]; other site 1205677007806 homodimer interface [polypeptide binding]; other site 1205677007807 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1205677007808 G-X-X-G motif; other site 1205677007809 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1205677007810 G-X-X-G motif; other site 1205677007811 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1205677007812 Sm and related proteins; Region: Sm_like; cl00259 1205677007813 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1205677007814 putative oligomer interface [polypeptide binding]; other site 1205677007815 putative RNA binding site [nucleotide binding]; other site 1205677007816 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1205677007817 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1205677007818 dinuclear metal binding motif [ion binding]; other site 1205677007819 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1205677007820 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1205677007821 dimer interface [polypeptide binding]; other site 1205677007822 motif 1; other site 1205677007823 active site 1205677007824 motif 2; other site 1205677007825 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1205677007826 putative deacylase active site [active] 1205677007827 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205677007828 active site 1205677007829 motif 3; other site 1205677007830 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1205677007831 anticodon binding site; other site 1205677007832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677007833 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205677007834 putative substrate translocation pore; other site 1205677007835 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1205677007836 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1205677007837 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1205677007838 homodimer interface [polypeptide binding]; other site 1205677007839 active site 1205677007840 SAM binding site [chemical binding]; other site 1205677007841 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1205677007842 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205677007843 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1205677007844 catalytic triad [active] 1205677007845 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1205677007846 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1205677007847 homodimer interface [polypeptide binding]; other site 1205677007848 Walker A motif; other site 1205677007849 ATP binding site [chemical binding]; other site 1205677007850 hydroxycobalamin binding site [chemical binding]; other site 1205677007851 Walker B motif; other site 1205677007852 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1205677007853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677007854 Walker A motif; other site 1205677007855 ATP binding site [chemical binding]; other site 1205677007856 Walker B motif; other site 1205677007857 arginine finger; other site 1205677007858 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1205677007859 metal ion-dependent adhesion site (MIDAS); other site 1205677007860 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1205677007861 malate:quinone oxidoreductase; Validated; Region: PRK05257 1205677007862 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1205677007863 PE family; Region: PE; pfam00934 1205677007864 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1205677007865 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205677007866 mycothione reductase; Reviewed; Region: PRK07846 1205677007867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677007868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677007869 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205677007870 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1205677007871 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205677007872 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205677007873 short chain dehydrogenase; Provisional; Region: PRK06057 1205677007874 classical (c) SDRs; Region: SDR_c; cd05233 1205677007875 NAD(P) binding site [chemical binding]; other site 1205677007876 active site 1205677007877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205677007878 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205677007879 NAD(P) binding site [chemical binding]; other site 1205677007880 catalytic residues [active] 1205677007881 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1205677007882 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1205677007883 catalytic triad [active] 1205677007884 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205677007885 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205677007886 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205677007887 Transposase; Region: HTH_Tnp_1; cl17663 1205677007888 putative transposase OrfB; Reviewed; Region: PHA02517 1205677007889 HTH-like domain; Region: HTH_21; pfam13276 1205677007890 Integrase core domain; Region: rve; pfam00665 1205677007891 Integrase core domain; Region: rve_3; cl15866 1205677007892 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205677007893 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205677007894 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205677007895 active site 1205677007896 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205677007897 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205677007898 putative active site [active] 1205677007899 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1205677007900 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205677007901 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205677007902 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205677007903 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205677007904 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1205677007905 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1205677007906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205677007907 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1205677007908 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205677007909 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205677007910 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1205677007911 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1205677007912 active site 1205677007913 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1205677007914 protein binding site [polypeptide binding]; other site 1205677007915 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1205677007916 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1205677007917 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1205677007918 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1205677007919 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677007920 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205677007921 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1205677007922 Fasciclin domain; Region: Fasciclin; pfam02469 1205677007923 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205677007924 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205677007925 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1205677007926 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205677007927 catalytic residues [active] 1205677007928 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1205677007929 Fasciclin domain; Region: Fasciclin; pfam02469 1205677007930 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1205677007931 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205677007932 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1205677007933 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205677007934 catalytic residues [active] 1205677007935 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1205677007936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677007937 FeS/SAM binding site; other site 1205677007938 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1205677007939 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1205677007940 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1205677007941 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1205677007942 hinge region; other site 1205677007943 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1205677007944 putative nucleotide binding site [chemical binding]; other site 1205677007945 uridine monophosphate binding site [chemical binding]; other site 1205677007946 homohexameric interface [polypeptide binding]; other site 1205677007947 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677007948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677007949 DNA binding site [nucleotide binding] 1205677007950 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205677007951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205677007952 Probable transposase; Region: OrfB_IS605; pfam01385 1205677007953 Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 15525680; Product type e : enzyme 1205677007954 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1205677007955 Helix-turn-helix domain; Region: HTH_28; pfam13518 1205677007956 Winged helix-turn helix; Region: HTH_29; pfam13551 1205677007957 Homeodomain-like domain; Region: HTH_32; pfam13565 1205677007958 Integrase core domain; Region: rve; pfam00665 1205677007959 Integrase core domain; Region: rve_3; pfam13683 1205677007960 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1205677007961 Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 15525680; Product type e : enzyme 1205677007962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205677007963 MarR family; Region: MarR; pfam01047 1205677007964 amidase; Provisional; Region: PRK07869 1205677007965 Amidase; Region: Amidase; pfam01425 1205677007966 elongation factor Ts; Provisional; Region: tsf; PRK09377 1205677007967 UBA/TS-N domain; Region: UBA; pfam00627 1205677007968 Elongation factor TS; Region: EF_TS; pfam00889 1205677007969 Elongation factor TS; Region: EF_TS; pfam00889 1205677007970 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1205677007971 rRNA interaction site [nucleotide binding]; other site 1205677007972 S8 interaction site; other site 1205677007973 putative laminin-1 binding site; other site 1205677007974 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205677007975 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205677007976 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677007977 PPE family; Region: PPE; pfam00823 1205677007978 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677007979 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1205677007980 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677007981 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1205677007982 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205677007983 active site 1205677007984 DNA binding site [nucleotide binding] 1205677007985 Int/Topo IB signature motif; other site 1205677007986 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205677007987 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205677007988 FAD binding pocket [chemical binding]; other site 1205677007989 FAD binding motif [chemical binding]; other site 1205677007990 phosphate binding motif [ion binding]; other site 1205677007991 NAD binding pocket [chemical binding]; other site 1205677007992 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1205677007993 DNA protecting protein DprA; Region: dprA; TIGR00732 1205677007994 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1205677007995 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205677007996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677007997 Walker A motif; other site 1205677007998 ATP binding site [chemical binding]; other site 1205677007999 Walker B motif; other site 1205677008000 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1205677008001 hypothetical protein; Reviewed; Region: PRK12497 1205677008002 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1205677008003 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1205677008004 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1205677008005 putative molybdopterin cofactor binding site [chemical binding]; other site 1205677008006 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1205677008007 putative molybdopterin cofactor binding site; other site 1205677008008 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1205677008009 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1205677008010 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205677008011 active site 1205677008012 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1205677008013 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1205677008014 Catalytic site [active] 1205677008015 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1205677008016 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1205677008017 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205677008018 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1205677008019 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1205677008020 RimM N-terminal domain; Region: RimM; pfam01782 1205677008021 hypothetical protein; Provisional; Region: PRK02821 1205677008022 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1205677008023 G-X-X-G motif; other site 1205677008024 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1205677008025 SnoaL-like domain; Region: SnoaL_4; pfam13577 1205677008026 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1205677008027 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205677008028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677008029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008030 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1205677008031 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1205677008032 active site 1205677008033 putative substrate binding pocket [chemical binding]; other site 1205677008034 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205677008035 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677008036 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677008037 active site 1205677008038 ATP binding site [chemical binding]; other site 1205677008039 substrate binding site [chemical binding]; other site 1205677008040 activation loop (A-loop); other site 1205677008041 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205677008042 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1205677008043 active site 1205677008044 signal recognition particle protein; Provisional; Region: PRK10867 1205677008045 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1205677008046 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1205677008047 P loop; other site 1205677008048 GTP binding site [chemical binding]; other site 1205677008049 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1205677008050 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205677008051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205677008052 ATP binding site [chemical binding]; other site 1205677008053 putative Mg++ binding site [ion binding]; other site 1205677008054 PII uridylyl-transferase; Provisional; Region: PRK03381 1205677008055 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1205677008056 metal binding triad [ion binding]; metal-binding site 1205677008057 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205677008058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205677008059 Zn2+ binding site [ion binding]; other site 1205677008060 Mg2+ binding site [ion binding]; other site 1205677008061 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1205677008062 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1205677008063 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1205677008064 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1205677008065 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1205677008066 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1205677008067 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205677008068 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1205677008069 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205677008070 Walker A/P-loop; other site 1205677008071 ATP binding site [chemical binding]; other site 1205677008072 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1205677008073 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205677008074 ABC transporter signature motif; other site 1205677008075 Walker B; other site 1205677008076 D-loop; other site 1205677008077 H-loop/switch region; other site 1205677008078 acylphosphatase; Provisional; Region: PRK14422 1205677008079 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1205677008080 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1205677008081 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1205677008082 DNA binding site [nucleotide binding] 1205677008083 catalytic residue [active] 1205677008084 H2TH interface [polypeptide binding]; other site 1205677008085 putative catalytic residues [active] 1205677008086 turnover-facilitating residue; other site 1205677008087 intercalation triad [nucleotide binding]; other site 1205677008088 8OG recognition residue [nucleotide binding]; other site 1205677008089 putative reading head residues; other site 1205677008090 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205677008091 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205677008092 ribonuclease III; Reviewed; Region: rnc; PRK00102 1205677008093 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1205677008094 dimerization interface [polypeptide binding]; other site 1205677008095 active site 1205677008096 metal binding site [ion binding]; metal-binding site 1205677008097 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1205677008098 dsRNA binding site [nucleotide binding]; other site 1205677008099 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1205677008100 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1205677008101 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1205677008102 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205677008103 acyl-CoA synthetase; Validated; Region: PRK05850 1205677008104 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677008105 acyl-activating enzyme (AAE) consensus motif; other site 1205677008106 active site 1205677008107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205677008108 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677008109 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677008110 active site 1205677008111 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205677008112 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677008113 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205677008114 NADP binding site [chemical binding]; other site 1205677008115 KR domain; Region: KR; pfam08659 1205677008116 active site 1205677008117 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677008118 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677008119 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205677008120 active site 1205677008121 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1205677008122 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205677008123 KR domain; Region: KR; pfam08659 1205677008124 NADP binding site [chemical binding]; other site 1205677008125 active site 1205677008126 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677008127 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677008128 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677008129 active site 1205677008130 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1205677008131 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677008132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677008133 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205677008134 Enoylreductase; Region: PKS_ER; smart00829 1205677008135 NAD(P) binding site [chemical binding]; other site 1205677008136 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205677008137 KR domain; Region: KR; pfam08659 1205677008138 putative NADP binding site [chemical binding]; other site 1205677008139 active site 1205677008140 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677008141 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677008142 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677008143 active site 1205677008144 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677008145 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677008146 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205677008147 KR domain; Region: KR; pfam08659 1205677008148 putative NADP binding site [chemical binding]; other site 1205677008149 active site 1205677008150 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677008151 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677008152 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677008153 active site 1205677008154 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677008155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205677008156 Condensation domain; Region: Condensation; pfam00668 1205677008157 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205677008158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677008159 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205677008160 Walker A/P-loop; other site 1205677008161 ATP binding site [chemical binding]; other site 1205677008162 Q-loop/lid; other site 1205677008163 ABC transporter signature motif; other site 1205677008164 Walker B; other site 1205677008165 D-loop; other site 1205677008166 H-loop/switch region; other site 1205677008167 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205677008168 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1205677008169 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1205677008170 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205677008171 acyltransferase PapA5; Provisional; Region: PRK09294 1205677008172 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677008173 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677008174 active site 1205677008175 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205677008176 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677008177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677008178 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205677008179 Enoylreductase; Region: PKS_ER; smart00829 1205677008180 NAD(P) binding site [chemical binding]; other site 1205677008181 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205677008182 KR domain; Region: KR; pfam08659 1205677008183 putative NADP binding site [chemical binding]; other site 1205677008184 active site 1205677008185 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677008186 acyl-CoA synthetase; Validated; Region: PRK05850 1205677008187 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677008188 acyl-activating enzyme (AAE) consensus motif; other site 1205677008189 active site 1205677008190 MMPL family; Region: MMPL; pfam03176 1205677008191 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205677008192 Erythronolide synthase docking; Region: Docking; pfam08990 1205677008193 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677008194 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677008195 active site 1205677008196 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677008197 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677008198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677008199 Enoylreductase; Region: PKS_ER; smart00829 1205677008200 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205677008201 NAD(P) binding site [chemical binding]; other site 1205677008202 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205677008203 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205677008204 putative NADP binding site [chemical binding]; other site 1205677008205 active site 1205677008206 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677008207 acyl-CoA synthetase; Validated; Region: PRK06060 1205677008208 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677008209 acyl-activating enzyme (AAE) consensus motif; other site 1205677008210 AMP binding site [chemical binding]; other site 1205677008211 active site 1205677008212 CoA binding site [chemical binding]; other site 1205677008213 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677008214 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1205677008215 acyl-CoA synthetase; Validated; Region: PRK05850 1205677008216 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677008217 acyl-activating enzyme (AAE) consensus motif; other site 1205677008218 active site 1205677008219 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205677008220 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205677008221 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677008222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677008223 S-adenosylmethionine binding site [chemical binding]; other site 1205677008224 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1205677008225 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205677008226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677008227 S-adenosylmethionine binding site [chemical binding]; other site 1205677008228 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205677008229 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205677008230 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1205677008231 metal-binding site 1205677008232 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205677008233 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205677008234 active site 1205677008235 TDP-binding site; other site 1205677008236 acceptor substrate-binding pocket; other site 1205677008237 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1205677008238 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1205677008239 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205677008240 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205677008241 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205677008242 active site 1205677008243 TDP-binding site; other site 1205677008244 acceptor substrate-binding pocket; other site 1205677008245 Predicted permease; Region: DUF318; pfam03773 1205677008246 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1205677008247 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1205677008248 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1205677008249 putative active site [active] 1205677008250 putative substrate binding site [chemical binding]; other site 1205677008251 putative cosubstrate binding site; other site 1205677008252 catalytic site [active] 1205677008253 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1205677008254 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1205677008255 active site 1205677008256 (T/H)XGH motif; other site 1205677008257 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1205677008258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677008259 S-adenosylmethionine binding site [chemical binding]; other site 1205677008260 pyruvate carboxylase; Reviewed; Region: PRK12999 1205677008261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205677008262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205677008263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205677008264 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1205677008265 active site 1205677008266 catalytic residues [active] 1205677008267 metal binding site [ion binding]; metal-binding site 1205677008268 homodimer binding site [polypeptide binding]; other site 1205677008269 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205677008270 carboxyltransferase (CT) interaction site; other site 1205677008271 biotinylation site [posttranslational modification]; other site 1205677008272 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1205677008273 putative active site [active] 1205677008274 redox center [active] 1205677008275 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1205677008276 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1205677008277 catalytic residues [active] 1205677008278 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205677008279 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677008280 substrate binding pocket [chemical binding]; other site 1205677008281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1205677008282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205677008283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205677008284 active site 1205677008285 catalytic tetrad [active] 1205677008286 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1205677008287 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1205677008288 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1205677008289 generic binding surface II; other site 1205677008290 ssDNA binding site; other site 1205677008291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677008292 ATP binding site [chemical binding]; other site 1205677008293 putative Mg++ binding site [ion binding]; other site 1205677008294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677008295 nucleotide binding region [chemical binding]; other site 1205677008296 ATP-binding site [chemical binding]; other site 1205677008297 DAK2 domain; Region: Dak2; cl03685 1205677008298 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1205677008299 Integrase core domain; Region: rve; pfam00665 1205677008300 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205677008301 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1205677008302 ligand binding site [chemical binding]; other site 1205677008303 active site 1205677008304 UGI interface [polypeptide binding]; other site 1205677008305 catalytic site [active] 1205677008306 thiamine monophosphate kinase; Provisional; Region: PRK05731 1205677008307 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1205677008308 ATP binding site [chemical binding]; other site 1205677008309 dimerization interface [polypeptide binding]; other site 1205677008310 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1205677008311 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1205677008312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1205677008313 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1205677008314 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1205677008315 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205677008316 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1205677008317 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1205677008318 polyphosphate kinase; Provisional; Region: PRK05443 1205677008319 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1205677008320 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1205677008321 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1205677008322 putative domain interface [polypeptide binding]; other site 1205677008323 putative active site [active] 1205677008324 catalytic site [active] 1205677008325 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1205677008326 putative domain interface [polypeptide binding]; other site 1205677008327 putative active site [active] 1205677008328 catalytic site [active] 1205677008329 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1205677008330 active site 1205677008331 Ap6A binding site [chemical binding]; other site 1205677008332 nudix motif; other site 1205677008333 metal binding site [ion binding]; metal-binding site 1205677008334 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677008335 catalytic core [active] 1205677008336 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1205677008337 IHF - DNA interface [nucleotide binding]; other site 1205677008338 IHF dimer interface [polypeptide binding]; other site 1205677008339 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1205677008340 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1205677008341 substrate binding site [chemical binding]; other site 1205677008342 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1205677008343 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1205677008344 substrate binding site [chemical binding]; other site 1205677008345 ligand binding site [chemical binding]; other site 1205677008346 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205677008347 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205677008348 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205677008349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677008350 S-adenosylmethionine binding site [chemical binding]; other site 1205677008351 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1205677008352 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205677008353 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1205677008354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677008355 active site 1205677008356 HIGH motif; other site 1205677008357 nucleotide binding site [chemical binding]; other site 1205677008358 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1205677008359 active site 1205677008360 KMSKS motif; other site 1205677008361 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1205677008362 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1205677008363 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205677008364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677008365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205677008366 putative substrate translocation pore; other site 1205677008367 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1205677008368 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1205677008369 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1205677008370 ligand binding site [chemical binding]; other site 1205677008371 NAD binding site [chemical binding]; other site 1205677008372 dimerization interface [polypeptide binding]; other site 1205677008373 catalytic site [active] 1205677008374 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1205677008375 putative L-serine binding site [chemical binding]; other site 1205677008376 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205677008377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677008378 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677008379 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677008380 active site 1205677008381 Evidence 4 : Homologs of previously reported genes of unknown function 1205677008382 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205677008383 Evidence 4 : Homologs of previously reported genes of unknown function 1205677008384 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1205677008385 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1205677008386 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1205677008387 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1205677008388 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1205677008389 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1205677008390 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1205677008391 putative valine binding site [chemical binding]; other site 1205677008392 dimer interface [polypeptide binding]; other site 1205677008393 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1205677008394 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1205677008395 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205677008396 PYR/PP interface [polypeptide binding]; other site 1205677008397 dimer interface [polypeptide binding]; other site 1205677008398 TPP binding site [chemical binding]; other site 1205677008399 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205677008400 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1205677008401 TPP-binding site [chemical binding]; other site 1205677008402 dimer interface [polypeptide binding]; other site 1205677008403 Integrase core domain; Region: rve; pfam00665 1205677008404 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205677008405 Predicted membrane protein [Function unknown]; Region: COG2259 1205677008406 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1205677008407 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1205677008408 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1205677008409 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1205677008410 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1205677008411 GatB domain; Region: GatB_Yqey; smart00845 1205677008412 6-phosphofructokinase; Provisional; Region: PRK03202 1205677008413 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1205677008414 active site 1205677008415 ADP/pyrophosphate binding site [chemical binding]; other site 1205677008416 dimerization interface [polypeptide binding]; other site 1205677008417 allosteric effector site; other site 1205677008418 fructose-1,6-bisphosphate binding site; other site 1205677008419 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205677008420 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1205677008421 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1205677008422 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1205677008423 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1205677008424 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1205677008425 nucleotide binding pocket [chemical binding]; other site 1205677008426 K-X-D-G motif; other site 1205677008427 catalytic site [active] 1205677008428 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1205677008429 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1205677008430 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1205677008431 Dimer interface [polypeptide binding]; other site 1205677008432 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1205677008433 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677008434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677008435 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677008436 PPE family; Region: PPE; pfam00823 1205677008437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677008438 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677008439 PPE family; Region: PPE; pfam00823 1205677008440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677008441 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1205677008442 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1205677008443 Ligand Binding Site [chemical binding]; other site 1205677008444 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1205677008445 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1205677008446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677008447 catalytic residue [active] 1205677008448 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677008449 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205677008450 putative acyl-acceptor binding pocket; other site 1205677008451 Putative hemolysin [General function prediction only]; Region: COG3176 1205677008452 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1205677008453 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1205677008454 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1205677008455 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1205677008456 Ligand binding site [chemical binding]; other site 1205677008457 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1205677008458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677008459 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677008460 S-adenosylmethionine binding site [chemical binding]; other site 1205677008461 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1205677008462 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1205677008463 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1205677008464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205677008465 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205677008466 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205677008467 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205677008468 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1205677008469 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1205677008470 trimer interface [polypeptide binding]; other site 1205677008471 active site 1205677008472 substrate binding site [chemical binding]; other site 1205677008473 CoA binding site [chemical binding]; other site 1205677008474 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1205677008475 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1205677008476 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677008477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677008478 S-adenosylmethionine binding site [chemical binding]; other site 1205677008479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677008480 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205677008481 substrate binding site [chemical binding]; other site 1205677008482 oxyanion hole (OAH) forming residues; other site 1205677008483 trimer interface [polypeptide binding]; other site 1205677008484 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1205677008485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677008486 Walker A/P-loop; other site 1205677008487 ATP binding site [chemical binding]; other site 1205677008488 Q-loop/lid; other site 1205677008489 ABC transporter signature motif; other site 1205677008490 Walker B; other site 1205677008491 D-loop; other site 1205677008492 H-loop/switch region; other site 1205677008493 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1205677008494 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1205677008495 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205677008496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677008497 motif II; other site 1205677008498 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1205677008499 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1205677008500 D-pathway; other site 1205677008501 Putative ubiquinol binding site [chemical binding]; other site 1205677008502 Low-spin heme (heme b) binding site [chemical binding]; other site 1205677008503 Putative water exit pathway; other site 1205677008504 Binuclear center (heme o3/CuB) [ion binding]; other site 1205677008505 K-pathway; other site 1205677008506 Putative proton exit pathway; other site 1205677008507 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1205677008508 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205677008509 siderophore binding site; other site 1205677008510 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1205677008511 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1205677008512 putative NAD(P) binding site [chemical binding]; other site 1205677008513 putative substrate binding site [chemical binding]; other site 1205677008514 catalytic Zn binding site [ion binding]; other site 1205677008515 structural Zn binding site [ion binding]; other site 1205677008516 dimer interface [polypeptide binding]; other site 1205677008517 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1205677008518 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1205677008519 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1205677008520 dimer interface [polypeptide binding]; other site 1205677008521 putative radical transfer pathway; other site 1205677008522 diiron center [ion binding]; other site 1205677008523 tyrosyl radical; other site 1205677008524 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205677008525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205677008526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677008527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008528 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1205677008529 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1205677008530 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1205677008531 active site 1205677008532 dimer interface [polypeptide binding]; other site 1205677008533 catalytic residues [active] 1205677008534 effector binding site; other site 1205677008535 R2 peptide binding site; other site 1205677008536 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1205677008537 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1205677008538 catalytic residues [active] 1205677008539 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205677008540 Predicted flavoprotein [General function prediction only]; Region: COG0431 1205677008541 DNA polymerase IV; Validated; Region: PRK03352 1205677008542 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1205677008543 active site 1205677008544 DNA binding site [nucleotide binding] 1205677008545 short chain dehydrogenase; Provisional; Region: PRK07832 1205677008546 classical (c) SDRs; Region: SDR_c; cd05233 1205677008547 NAD(P) binding site [chemical binding]; other site 1205677008548 active site 1205677008549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677008550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008551 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677008552 Cytochrome P450; Region: p450; cl12078 1205677008553 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205677008554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677008555 DNA-binding site [nucleotide binding]; DNA binding site 1205677008556 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1205677008557 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205677008558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205677008559 DNA-binding site [nucleotide binding]; DNA binding site 1205677008560 FCD domain; Region: FCD; pfam07729 1205677008561 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205677008562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677008563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677008564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677008565 active site 1205677008566 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1205677008567 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1205677008568 active site 1205677008569 DNA binding site [nucleotide binding] 1205677008570 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1205677008571 DNA binding site [nucleotide binding] 1205677008572 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1205677008573 Carbon starvation protein CstA; Region: CstA; pfam02554 1205677008574 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1205677008575 Predicted membrane protein [Function unknown]; Region: COG2259 1205677008576 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1205677008577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205677008578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008579 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677008580 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1205677008581 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1205677008582 active site 1205677008583 substrate binding site [chemical binding]; other site 1205677008584 metal binding site [ion binding]; metal-binding site 1205677008585 camphor resistance protein CrcB; Provisional; Region: PRK14216 1205677008586 camphor resistance protein CrcB; Provisional; Region: PRK14228 1205677008587 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1205677008588 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1205677008589 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1205677008590 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205677008591 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677008592 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1205677008593 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677008594 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677008595 active site 1205677008596 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205677008597 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205677008598 putative hydrophobic ligand binding site [chemical binding]; other site 1205677008599 protein interface [polypeptide binding]; other site 1205677008600 gate; other site 1205677008601 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205677008602 Sulfatase; Region: Sulfatase; pfam00884 1205677008603 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205677008604 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677008605 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205677008606 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205677008607 active site 1205677008608 ATP binding site [chemical binding]; other site 1205677008609 substrate binding site [chemical binding]; other site 1205677008610 activation loop (A-loop); other site 1205677008611 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1205677008612 AAA ATPase domain; Region: AAA_16; pfam13191 1205677008613 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 1205677008614 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205677008615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205677008616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205677008617 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205677008618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205677008619 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677008620 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1205677008621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677008622 NAD(P) binding site [chemical binding]; other site 1205677008623 active site 1205677008624 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1205677008625 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205677008626 NAD binding site [chemical binding]; other site 1205677008627 catalytic Zn binding site [ion binding]; other site 1205677008628 substrate binding site [chemical binding]; other site 1205677008629 structural Zn binding site [ion binding]; other site 1205677008630 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677008631 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677008632 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677008633 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677008634 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1205677008635 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1205677008636 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677008637 acyl-activating enzyme (AAE) consensus motif; other site 1205677008638 AMP binding site [chemical binding]; other site 1205677008639 active site 1205677008640 CoA binding site [chemical binding]; other site 1205677008641 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1205677008642 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205677008643 Patatin-like phospholipase; Region: Patatin; pfam01734 1205677008644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1205677008645 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1205677008646 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677008647 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677008648 active site 1205677008649 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205677008650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677008651 dimerization interface [polypeptide binding]; other site 1205677008652 putative DNA binding site [nucleotide binding]; other site 1205677008653 putative Zn2+ binding site [ion binding]; other site 1205677008654 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1205677008655 PE family; Region: PE; pfam00934 1205677008656 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677008657 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205677008658 PE family; Region: PE; pfam00934 1205677008659 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677008660 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205677008661 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1205677008662 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205677008663 active site 1205677008664 catalytic site [active] 1205677008665 substrate binding site [chemical binding]; other site 1205677008666 Predicted helicase [General function prediction only]; Region: COG4889 1205677008667 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677008668 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677008669 active site 1205677008670 De-etiolated protein 1 Det1; Region: Det1; pfam09737 1205677008671 PemK-like protein; Region: PemK; pfam02452 1205677008672 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205677008673 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205677008674 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205677008675 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1205677008676 SmpB-tmRNA interface; other site 1205677008677 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1205677008678 FtsX-like permease family; Region: FtsX; pfam02687 1205677008679 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205677008680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205677008681 Walker A/P-loop; other site 1205677008682 ATP binding site [chemical binding]; other site 1205677008683 Q-loop/lid; other site 1205677008684 ABC transporter signature motif; other site 1205677008685 Walker B; other site 1205677008686 D-loop; other site 1205677008687 H-loop/switch region; other site 1205677008688 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1205677008689 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1205677008690 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1205677008691 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205677008692 RF-1 domain; Region: RF-1; pfam00472 1205677008693 ferredoxin-NADP+ reductase; Region: PLN02852 1205677008694 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677008695 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677008696 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1205677008697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677008698 FeS/SAM binding site; other site 1205677008699 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205677008700 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205677008701 aromatic arch; other site 1205677008702 DCoH dimer interaction site [polypeptide binding]; other site 1205677008703 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205677008704 DCoH tetramer interaction site [polypeptide binding]; other site 1205677008705 substrate binding site [chemical binding]; other site 1205677008706 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205677008707 trimer interface [polypeptide binding]; other site 1205677008708 dimer interface [polypeptide binding]; other site 1205677008709 putative active site [active] 1205677008710 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1205677008711 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205677008712 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205677008713 nucleoside/Zn binding site; other site 1205677008714 dimer interface [polypeptide binding]; other site 1205677008715 catalytic motif [active] 1205677008716 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1205677008717 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1205677008718 ATP binding site [chemical binding]; other site 1205677008719 substrate interface [chemical binding]; other site 1205677008720 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205677008721 active site residue [active] 1205677008722 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205677008723 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205677008724 active site residue [active] 1205677008725 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205677008726 active site residue [active] 1205677008727 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1205677008728 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205677008729 MoaE homodimer interface [polypeptide binding]; other site 1205677008730 MoaD interaction [polypeptide binding]; other site 1205677008731 active site residues [active] 1205677008732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677008733 S-adenosylmethionine binding site [chemical binding]; other site 1205677008734 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677008735 Cytochrome P450; Region: p450; cl12078 1205677008736 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205677008737 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205677008738 DNA binding site [nucleotide binding] 1205677008739 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677008740 PPE family; Region: PPE; pfam00823 1205677008741 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205677008742 putative transposase OrfB; Reviewed; Region: PHA02517 1205677008743 HTH-like domain; Region: HTH_21; pfam13276 1205677008744 Integrase core domain; Region: rve; pfam00665 1205677008745 Integrase core domain; Region: rve_3; cl15866 1205677008746 Transposase; Region: HTH_Tnp_1; cl17663 1205677008747 Integrase core domain; Region: rve; pfam00665 1205677008748 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677008749 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677008750 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205677008751 dimer interface [polypeptide binding]; other site 1205677008752 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205677008753 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205677008754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205677008755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205677008756 Histidine kinase; Region: HisKA_3; pfam07730 1205677008757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677008758 ATP binding site [chemical binding]; other site 1205677008759 Mg2+ binding site [ion binding]; other site 1205677008760 G-X-G motif; other site 1205677008761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205677008762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677008763 active site 1205677008764 phosphorylation site [posttranslational modification] 1205677008765 intermolecular recognition site; other site 1205677008766 dimerization interface [polypeptide binding]; other site 1205677008767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205677008768 DNA binding residues [nucleotide binding] 1205677008769 dimerization interface [polypeptide binding]; other site 1205677008770 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205677008771 Ligand Binding Site [chemical binding]; other site 1205677008772 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677008773 PPE family; Region: PPE; pfam00823 1205677008774 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677008775 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677008776 PPE family; Region: PPE; pfam00823 1205677008777 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677008778 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205677008779 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1205677008780 active site 1205677008781 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1205677008782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677008783 FeS/SAM binding site; other site 1205677008784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677008785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677008786 active site 1205677008787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677008788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677008789 active site 1205677008790 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205677008791 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1205677008792 NAD(P) binding site [chemical binding]; other site 1205677008793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677008794 active site 1205677008795 phosphorylation site [posttranslational modification] 1205677008796 intermolecular recognition site; other site 1205677008797 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677008798 PPE family; Region: PPE; pfam00823 1205677008799 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1205677008800 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1205677008801 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1205677008802 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1205677008803 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1205677008804 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1205677008805 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1205677008806 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1205677008807 putative dimer interface [polypeptide binding]; other site 1205677008808 [2Fe-2S] cluster binding site [ion binding]; other site 1205677008809 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1205677008810 SLBB domain; Region: SLBB; pfam10531 1205677008811 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1205677008812 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1205677008813 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677008814 catalytic loop [active] 1205677008815 iron binding site [ion binding]; other site 1205677008816 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1205677008817 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1205677008818 [4Fe-4S] binding site [ion binding]; other site 1205677008819 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1205677008820 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1205677008821 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1205677008822 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1205677008823 4Fe-4S binding domain; Region: Fer4; pfam00037 1205677008824 4Fe-4S binding domain; Region: Fer4; pfam00037 1205677008825 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1205677008826 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1205677008827 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1205677008828 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1205677008829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205677008830 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1205677008831 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205677008832 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1205677008833 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205677008834 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677008835 PPE family; Region: PPE; pfam00823 1205677008836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677008837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008838 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1205677008839 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1205677008840 [2Fe-2S] cluster binding site [ion binding]; other site 1205677008841 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1205677008842 putative alpha subunit interface [polypeptide binding]; other site 1205677008843 putative active site [active] 1205677008844 putative substrate binding site [chemical binding]; other site 1205677008845 Fe binding site [ion binding]; other site 1205677008846 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205677008847 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205677008848 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205677008849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677008850 Walker A motif; other site 1205677008851 ATP binding site [chemical binding]; other site 1205677008852 Walker B motif; other site 1205677008853 arginine finger; other site 1205677008854 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1205677008855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677008856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008857 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1205677008858 putative active site [active] 1205677008859 putative substrate binding site [chemical binding]; other site 1205677008860 ATP binding site [chemical binding]; other site 1205677008861 Phosphotransferase enzyme family; Region: APH; pfam01636 1205677008862 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1205677008863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677008864 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205677008865 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677008866 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205677008867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677008868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008869 short chain dehydrogenase; Validated; Region: PRK08264 1205677008870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677008871 NAD(P) binding site [chemical binding]; other site 1205677008872 active site 1205677008873 amidase; Provisional; Region: PRK06170 1205677008874 Amidase; Region: Amidase; pfam01425 1205677008875 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677008876 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677008877 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205677008878 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205677008879 DDE superfamily endonuclease; Region: DDE_5; cl17874 1205677008880 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1205677008881 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205677008882 AAA domain; Region: AAA_14; pfam13173 1205677008883 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205677008884 putative active site [active] 1205677008885 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205677008886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1205677008887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205677008888 non-specific DNA binding site [nucleotide binding]; other site 1205677008889 salt bridge; other site 1205677008890 sequence-specific DNA binding site [nucleotide binding]; other site 1205677008891 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1205677008892 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677008893 RES domain; Region: RES; cl02411 1205677008894 Winged helix-turn helix; Region: HTH_29; pfam13551 1205677008895 Homeodomain-like domain; Region: HTH_32; pfam13565 1205677008896 Integrase core domain; Region: rve; pfam00665 1205677008897 Integrase core domain; Region: rve_3; pfam13683 1205677008898 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677008899 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1205677008900 hypothetical protein; Validated; Region: PRK00068 1205677008901 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1205677008902 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1205677008903 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1205677008904 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1205677008905 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1205677008906 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1205677008907 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205677008908 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1205677008909 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1205677008910 ABC1 family; Region: ABC1; pfam03109 1205677008911 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1205677008912 active site 1205677008913 ATP binding site [chemical binding]; other site 1205677008914 Transcription factor WhiB; Region: Whib; pfam02467 1205677008915 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205677008916 Part of AAA domain; Region: AAA_19; pfam13245 1205677008917 Family description; Region: UvrD_C_2; pfam13538 1205677008918 HRDC domain; Region: HRDC; pfam00570 1205677008919 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1205677008920 catalytic residues [active] 1205677008921 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1205677008922 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1205677008923 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1205677008924 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1205677008925 putative NADH binding site [chemical binding]; other site 1205677008926 putative active site [active] 1205677008927 nudix motif; other site 1205677008928 putative metal binding site [ion binding]; other site 1205677008929 Ion channel; Region: Ion_trans_2; pfam07885 1205677008930 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205677008931 TrkA-N domain; Region: TrkA_N; pfam02254 1205677008932 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205677008933 Part of AAA domain; Region: AAA_19; pfam13245 1205677008934 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205677008935 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205677008936 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205677008937 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205677008938 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205677008939 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205677008940 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205677008941 active site 1205677008942 DNA binding site [nucleotide binding] 1205677008943 TIGR02569 family protein; Region: TIGR02569_actnb 1205677008944 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1205677008945 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1205677008946 ATP binding site [chemical binding]; other site 1205677008947 substrate interface [chemical binding]; other site 1205677008948 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205677008949 active site residue [active] 1205677008950 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1205677008951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205677008952 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677008953 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1205677008954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677008955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677008956 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1205677008957 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1205677008958 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205677008959 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205677008960 ATP binding site [chemical binding]; other site 1205677008961 Mg++ binding site [ion binding]; other site 1205677008962 motif III; other site 1205677008963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677008964 nucleotide binding region [chemical binding]; other site 1205677008965 ATP-binding site [chemical binding]; other site 1205677008966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205677008967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205677008968 P-loop; other site 1205677008969 Magnesium ion binding site [ion binding]; other site 1205677008970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205677008971 Magnesium ion binding site [ion binding]; other site 1205677008972 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677008973 catalytic core [active] 1205677008974 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1205677008975 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205677008976 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1205677008977 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205677008978 Transcription factor WhiB; Region: Whib; pfam02467 1205677008979 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1205677008980 PAS domain S-box; Region: sensory_box; TIGR00229 1205677008981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1205677008982 Histidine kinase; Region: HisKA_2; pfam07568 1205677008983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677008984 ATP binding site [chemical binding]; other site 1205677008985 Mg2+ binding site [ion binding]; other site 1205677008986 G-X-G motif; other site 1205677008987 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205677008988 carboxyltransferase (CT) interaction site; other site 1205677008989 biotinylation site [posttranslational modification]; other site 1205677008990 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1205677008991 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1205677008992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677008993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677008994 DNA binding residues [nucleotide binding] 1205677008995 short chain dehydrogenase; Provisional; Region: PRK08278 1205677008996 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1205677008997 NAD(P) binding site [chemical binding]; other site 1205677008998 homodimer interface [polypeptide binding]; other site 1205677008999 active site 1205677009000 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1205677009001 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1205677009002 putative deacylase active site [active] 1205677009003 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205677009004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205677009005 Coenzyme A binding pocket [chemical binding]; other site 1205677009006 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1205677009007 Phosphotransferase enzyme family; Region: APH; pfam01636 1205677009008 putative active site [active] 1205677009009 putative substrate binding site [chemical binding]; other site 1205677009010 ATP binding site [chemical binding]; other site 1205677009011 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1205677009012 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1205677009013 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1205677009014 hinge; other site 1205677009015 active site 1205677009016 Predicted GTPases [General function prediction only]; Region: COG1162 1205677009017 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1205677009018 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1205677009019 GTP/Mg2+ binding site [chemical binding]; other site 1205677009020 G4 box; other site 1205677009021 G5 box; other site 1205677009022 G1 box; other site 1205677009023 Switch I region; other site 1205677009024 G2 box; other site 1205677009025 G3 box; other site 1205677009026 Switch II region; other site 1205677009027 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205677009028 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1205677009029 putative di-iron ligands [ion binding]; other site 1205677009030 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1205677009031 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205677009032 FAD binding pocket [chemical binding]; other site 1205677009033 FAD binding motif [chemical binding]; other site 1205677009034 phosphate binding motif [ion binding]; other site 1205677009035 beta-alpha-beta structure motif; other site 1205677009036 NAD binding pocket [chemical binding]; other site 1205677009037 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677009038 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1205677009039 catalytic loop [active] 1205677009040 iron binding site [ion binding]; other site 1205677009041 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1205677009042 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677009043 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677009044 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1205677009045 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1205677009046 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1205677009047 TrkA-C domain; Region: TrkA_C; pfam02080 1205677009048 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1205677009049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677009050 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205677009051 putative substrate translocation pore; other site 1205677009052 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677009053 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677009054 ligand binding site [chemical binding]; other site 1205677009055 flexible hinge region; other site 1205677009056 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205677009057 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205677009058 nucleophile elbow; other site 1205677009059 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1205677009060 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1205677009061 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1205677009062 30S subunit binding site; other site 1205677009063 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1205677009064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1205677009065 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205677009066 lipoprotein LpqB; Provisional; Region: PRK13616 1205677009067 Sporulation and spore germination; Region: Germane; pfam10646 1205677009068 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205677009069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677009070 dimerization interface [polypeptide binding]; other site 1205677009071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677009072 dimer interface [polypeptide binding]; other site 1205677009073 phosphorylation site [posttranslational modification] 1205677009074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677009075 ATP binding site [chemical binding]; other site 1205677009076 Mg2+ binding site [ion binding]; other site 1205677009077 G-X-G motif; other site 1205677009078 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677009079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677009080 active site 1205677009081 phosphorylation site [posttranslational modification] 1205677009082 intermolecular recognition site; other site 1205677009083 dimerization interface [polypeptide binding]; other site 1205677009084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677009085 DNA binding site [nucleotide binding] 1205677009086 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1205677009087 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1205677009088 TMP-binding site; other site 1205677009089 ATP-binding site [chemical binding]; other site 1205677009090 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1205677009091 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1205677009092 homotetramer interface [polypeptide binding]; other site 1205677009093 ligand binding site [chemical binding]; other site 1205677009094 catalytic site [active] 1205677009095 NAD binding site [chemical binding]; other site 1205677009096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677009097 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1205677009098 Rubredoxin [Energy production and conversion]; Region: COG1773 1205677009099 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1205677009100 iron binding site [ion binding]; other site 1205677009101 Rubredoxin [Energy production and conversion]; Region: COG1773 1205677009102 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1205677009103 iron binding site [ion binding]; other site 1205677009104 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1205677009105 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1205677009106 Di-iron ligands [ion binding]; other site 1205677009107 amino acid transporter; Region: 2A0306; TIGR00909 1205677009108 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1205677009109 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1205677009110 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1205677009111 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205677009112 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205677009113 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1205677009114 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1205677009115 active site 1205677009116 substrate binding site [chemical binding]; other site 1205677009117 metal binding site [ion binding]; metal-binding site 1205677009118 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1205677009119 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1205677009120 Transcription factor WhiB; Region: Whib; pfam02467 1205677009121 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1205677009122 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1205677009123 phosphate binding site [ion binding]; other site 1205677009124 dimer interface [polypeptide binding]; other site 1205677009125 substrate binding site [chemical binding]; other site 1205677009126 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1205677009127 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1205677009128 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1205677009129 putative FMN binding site [chemical binding]; other site 1205677009130 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205677009131 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1205677009132 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205677009133 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1205677009134 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1205677009135 active site 1205677009136 Substrate binding site; other site 1205677009137 Mg++ binding site; other site 1205677009138 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1205677009139 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205677009140 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205677009141 Probable Catalytic site; other site 1205677009142 metal-binding site 1205677009143 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1205677009144 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1205677009145 NADP binding site [chemical binding]; other site 1205677009146 active site 1205677009147 putative substrate binding site [chemical binding]; other site 1205677009148 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205677009149 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205677009150 TIGR03089 family protein; Region: TIGR03089 1205677009151 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205677009152 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205677009153 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677009154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1205677009155 active site 1205677009156 motif I; other site 1205677009157 motif II; other site 1205677009158 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677009159 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677009160 active site 1205677009161 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205677009162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205677009163 Probable transposase; Region: OrfB_IS605; pfam01385 1205677009164 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205677009165 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205677009166 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205677009167 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205677009168 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1205677009169 active site clefts [active] 1205677009170 zinc binding site [ion binding]; other site 1205677009171 dimer interface [polypeptide binding]; other site 1205677009172 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009173 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1205677009174 FAD binding site [chemical binding]; other site 1205677009175 homotetramer interface [polypeptide binding]; other site 1205677009176 substrate binding pocket [chemical binding]; other site 1205677009177 catalytic base [active] 1205677009178 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1205677009179 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1205677009180 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205677009181 Predicted membrane protein [Function unknown]; Region: COG2246 1205677009182 GtrA-like protein; Region: GtrA; pfam04138 1205677009183 Bacterial PH domain; Region: DUF304; pfam03703 1205677009184 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1205677009185 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1205677009186 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1205677009187 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205677009188 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205677009189 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205677009190 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1205677009191 Maf-like protein; Region: Maf; pfam02545 1205677009192 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1205677009193 active site 1205677009194 dimer interface [polypeptide binding]; other site 1205677009195 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205677009196 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205677009197 active site residue [active] 1205677009198 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205677009199 active site residue [active] 1205677009200 Fe-S metabolism associated domain; Region: SufE; pfam02657 1205677009201 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205677009202 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205677009203 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1205677009204 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205677009205 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205677009206 carboxyltransferase (CT) interaction site; other site 1205677009207 biotinylation site [posttranslational modification]; other site 1205677009208 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1205677009209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677009210 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205677009211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1205677009212 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1205677009213 L-lysine aminotransferase; Provisional; Region: PRK08297 1205677009214 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205677009215 inhibitor-cofactor binding pocket; inhibition site 1205677009216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677009217 catalytic residue [active] 1205677009218 putative DNA binding site [nucleotide binding]; other site 1205677009219 dimerization interface [polypeptide binding]; other site 1205677009220 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205677009221 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205677009222 putative Zn2+ binding site [ion binding]; other site 1205677009223 AsnC family; Region: AsnC_trans_reg; pfam01037 1205677009224 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1205677009225 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1205677009226 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205677009227 tetrameric interface [polypeptide binding]; other site 1205677009228 NAD binding site [chemical binding]; other site 1205677009229 catalytic residues [active] 1205677009230 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205677009231 AAA domain; Region: AAA_14; pfam13173 1205677009232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677009233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677009234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677009235 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1205677009236 ATP binding site [chemical binding]; other site 1205677009237 putative Mg++ binding site [ion binding]; other site 1205677009238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677009239 nucleotide binding region [chemical binding]; other site 1205677009240 ATP-binding site [chemical binding]; other site 1205677009241 DEAD/H associated; Region: DEAD_assoc; pfam08494 1205677009242 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205677009243 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1205677009244 putative DNA binding site [nucleotide binding]; other site 1205677009245 catalytic residue [active] 1205677009246 putative H2TH interface [polypeptide binding]; other site 1205677009247 putative catalytic residues [active] 1205677009248 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205677009249 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1205677009250 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205677009251 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205677009252 Sulfatase; Region: Sulfatase; pfam00884 1205677009253 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1205677009254 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1205677009255 probable active site [active] 1205677009256 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1205677009257 PhoU domain; Region: PhoU; pfam01895 1205677009258 PhoU domain; Region: PhoU; pfam01895 1205677009259 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1205677009260 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1205677009261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677009262 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205677009263 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1205677009264 putative active site pocket [active] 1205677009265 dimerization interface [polypeptide binding]; other site 1205677009266 putative catalytic residue [active] 1205677009267 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1205677009268 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1205677009269 metal binding site [ion binding]; metal-binding site 1205677009270 putative dimer interface [polypeptide binding]; other site 1205677009271 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1205677009272 amidohydrolase; Region: amidohydrolases; TIGR01891 1205677009273 metal binding site [ion binding]; metal-binding site 1205677009274 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1205677009275 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1205677009276 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1205677009277 active site 1205677009278 substrate binding site [chemical binding]; other site 1205677009279 metal binding site [ion binding]; metal-binding site 1205677009280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677009281 active site 1205677009282 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205677009283 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677009284 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1205677009285 adenosine deaminase; Provisional; Region: PRK09358 1205677009286 active site 1205677009287 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1205677009288 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205677009289 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205677009290 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1205677009291 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1205677009292 active site 1205677009293 catalytic motif [active] 1205677009294 Zn binding site [ion binding]; other site 1205677009295 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1205677009296 putative Iron-sulfur protein interface [polypeptide binding]; other site 1205677009297 putative proximal heme binding site [chemical binding]; other site 1205677009298 putative SdhD-like interface [polypeptide binding]; other site 1205677009299 putative distal heme binding site [chemical binding]; other site 1205677009300 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1205677009301 putative Iron-sulfur protein interface [polypeptide binding]; other site 1205677009302 putative proximal heme binding site [chemical binding]; other site 1205677009303 putative SdhC-like subunit interface [polypeptide binding]; other site 1205677009304 putative distal heme binding site [chemical binding]; other site 1205677009305 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1205677009306 L-aspartate oxidase; Provisional; Region: PRK06175 1205677009307 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205677009308 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1205677009309 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1205677009310 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205677009311 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205677009312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677009313 S-adenosylmethionine binding site [chemical binding]; other site 1205677009314 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205677009315 MoaE interaction surface [polypeptide binding]; other site 1205677009316 MoeB interaction surface [polypeptide binding]; other site 1205677009317 thiocarboxylated glycine; other site 1205677009318 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205677009319 MoaE homodimer interface [polypeptide binding]; other site 1205677009320 MoaD interaction [polypeptide binding]; other site 1205677009321 active site residues [active] 1205677009322 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205677009323 trimer interface [polypeptide binding]; other site 1205677009324 dimer interface [polypeptide binding]; other site 1205677009325 putative active site [active] 1205677009326 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205677009327 aromatic arch; other site 1205677009328 DCoH dimer interaction site [polypeptide binding]; other site 1205677009329 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205677009330 DCoH tetramer interaction site [polypeptide binding]; other site 1205677009331 substrate binding site [chemical binding]; other site 1205677009332 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1205677009333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677009334 FeS/SAM binding site; other site 1205677009335 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205677009336 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205677009337 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205677009338 DNA binding site [nucleotide binding] 1205677009339 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205677009340 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677009341 phosphopeptide binding site; other site 1205677009342 Condensation domain; Region: Condensation; pfam00668 1205677009343 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205677009344 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1205677009345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677009346 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1205677009347 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205677009348 hypothetical protein; Provisional; Region: PRK06541 1205677009349 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205677009350 inhibitor-cofactor binding pocket; inhibition site 1205677009351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677009352 catalytic residue [active] 1205677009353 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205677009354 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1205677009355 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1205677009356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677009357 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1205677009358 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1205677009359 active site 1205677009360 dimer interface [polypeptide binding]; other site 1205677009361 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205677009362 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1205677009363 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205677009364 DNA binding residues [nucleotide binding] 1205677009365 dimer interface [polypeptide binding]; other site 1205677009366 metal binding site [ion binding]; metal-binding site 1205677009367 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1205677009368 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1205677009369 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1205677009370 active site 1205677009371 HIGH motif; other site 1205677009372 dimer interface [polypeptide binding]; other site 1205677009373 KMSKS motif; other site 1205677009374 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677009375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205677009376 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677009377 isocitrate dehydrogenase; Validated; Region: PRK08299 1205677009378 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1205677009379 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205677009380 homodimer interface [polypeptide binding]; other site 1205677009381 substrate-cofactor binding pocket; other site 1205677009382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677009383 catalytic residue [active] 1205677009384 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1205677009385 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1205677009386 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205677009387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677009388 S-adenosylmethionine binding site [chemical binding]; other site 1205677009389 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1205677009390 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1205677009391 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1205677009392 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1205677009393 homodimer interface [polypeptide binding]; other site 1205677009394 NADP binding site [chemical binding]; other site 1205677009395 substrate binding site [chemical binding]; other site 1205677009396 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205677009397 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1205677009398 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205677009399 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205677009400 PPE family; Region: PPE; pfam00823 1205677009401 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009402 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009403 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009404 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009405 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009406 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009407 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009408 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009409 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009410 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009411 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009412 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009413 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009414 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009415 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009416 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009417 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009418 PE family; Region: PE; pfam00934 1205677009419 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009420 PPE family; Region: PPE; pfam00823 1205677009421 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009422 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009423 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009424 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009425 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009426 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009427 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009428 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009429 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009430 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009431 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009432 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009433 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009434 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009435 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205677009437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677009438 ATP binding site [chemical binding]; other site 1205677009439 Mg2+ binding site [ion binding]; other site 1205677009440 G-X-G motif; other site 1205677009441 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1205677009442 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1205677009443 FMN binding site [chemical binding]; other site 1205677009444 dimer interface [polypeptide binding]; other site 1205677009445 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 1205677009446 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1205677009447 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1205677009448 active site 1205677009449 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1205677009450 generic binding surface II; other site 1205677009451 generic binding surface I; other site 1205677009452 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677009453 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677009454 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1205677009455 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1205677009456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677009457 active site 1205677009458 motif I; other site 1205677009459 motif II; other site 1205677009460 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1205677009461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677009462 substrate binding site [chemical binding]; other site 1205677009463 oxyanion hole (OAH) forming residues; other site 1205677009464 trimer interface [polypeptide binding]; other site 1205677009465 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680; Product type pe : putative enzyme 1205677009466 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680; Product type pe : putative enzyme 1205677009467 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1205677009468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677009469 motif II; other site 1205677009470 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1205677009471 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1205677009472 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1205677009473 TPP-binding site [chemical binding]; other site 1205677009474 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1205677009475 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205677009476 PYR/PP interface [polypeptide binding]; other site 1205677009477 dimer interface [polypeptide binding]; other site 1205677009478 TPP binding site [chemical binding]; other site 1205677009479 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205677009480 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1205677009481 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1205677009482 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10412909, 12657046, 15525680; Product type pe : putative enzyme 1205677009483 Transposase; Region: HTH_Tnp_1; pfam01527 1205677009484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205677009485 putative transposase OrfB; Reviewed; Region: PHA02517 1205677009486 HTH-like domain; Region: HTH_21; pfam13276 1205677009487 Integrase core domain; Region: rve; pfam00665 1205677009488 Integrase core domain; Region: rve_3; pfam13683 1205677009489 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10412909, 12657046, 15525680; Product type pe : putative enzyme 1205677009490 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205677009491 putative active site [active] 1205677009492 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205677009493 enoyl-CoA hydratase; Region: PLN02864 1205677009494 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205677009495 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1205677009496 dimer interaction site [polypeptide binding]; other site 1205677009497 substrate-binding tunnel; other site 1205677009498 active site 1205677009499 catalytic site [active] 1205677009500 substrate binding site [chemical binding]; other site 1205677009501 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677009502 short chain dehydrogenase; Provisional; Region: PRK07201 1205677009503 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1205677009504 putative NAD(P) binding site [chemical binding]; other site 1205677009505 active site 1205677009506 putative substrate binding site [chemical binding]; other site 1205677009507 classical (c) SDRs; Region: SDR_c; cd05233 1205677009508 NAD(P) binding site [chemical binding]; other site 1205677009509 active site 1205677009510 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677009511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677009512 S-adenosylmethionine binding site [chemical binding]; other site 1205677009513 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1205677009514 active site 1205677009515 DNA Polymerase Y-family; Region: PolY_like; cd03468 1205677009516 DNA binding site [nucleotide binding] 1205677009517 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1205677009518 GMP synthase; Reviewed; Region: guaA; PRK00074 1205677009519 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1205677009520 AMP/PPi binding site [chemical binding]; other site 1205677009521 candidate oxyanion hole; other site 1205677009522 catalytic triad [active] 1205677009523 potential glutamine specificity residues [chemical binding]; other site 1205677009524 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1205677009525 ATP Binding subdomain [chemical binding]; other site 1205677009526 Ligand Binding sites [chemical binding]; other site 1205677009527 Dimerization subdomain; other site 1205677009528 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1205677009529 active site lid residues [active] 1205677009530 substrate binding pocket [chemical binding]; other site 1205677009531 catalytic residues [active] 1205677009532 substrate-Mg2+ binding site; other site 1205677009533 aspartate-rich region 1; other site 1205677009534 aspartate-rich region 2; other site 1205677009535 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205677009536 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205677009537 substrate binding pocket [chemical binding]; other site 1205677009538 chain length determination region; other site 1205677009539 substrate-Mg2+ binding site; other site 1205677009540 catalytic residues [active] 1205677009541 aspartate-rich region 1; other site 1205677009542 active site lid residues [active] 1205677009543 aspartate-rich region 2; other site 1205677009544 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677009545 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677009546 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1205677009547 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205677009548 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1205677009549 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1205677009550 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1205677009551 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1205677009552 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1205677009553 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205677009554 inhibitor-cofactor binding pocket; inhibition site 1205677009555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677009556 catalytic residue [active] 1205677009557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1205677009558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677009559 hypothetical protein; Provisional; Region: PRK07579 1205677009560 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1205677009561 active site 1205677009562 cosubstrate binding site; other site 1205677009563 substrate binding site [chemical binding]; other site 1205677009564 catalytic site [active] 1205677009565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677009566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677009567 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1205677009568 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1205677009569 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205677009570 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1205677009571 putative active site [active] 1205677009572 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1205677009573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677009574 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205677009575 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1205677009576 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205677009577 phosphate binding site [ion binding]; other site 1205677009578 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1205677009579 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205677009580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1205677009581 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205677009582 active site 1205677009583 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 17443846 1205677009584 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1205677009585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677009586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677009587 DNA binding residues [nucleotide binding] 1205677009588 Transcription factor WhiB; Region: Whib; pfam02467 1205677009589 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205677009590 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205677009591 ring oligomerisation interface [polypeptide binding]; other site 1205677009592 ATP/Mg binding site [chemical binding]; other site 1205677009593 stacking interactions; other site 1205677009594 hinge regions; other site 1205677009595 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1205677009596 oligomerisation interface [polypeptide binding]; other site 1205677009597 mobile loop; other site 1205677009598 roof hairpin; other site 1205677009599 UGMP family protein; Validated; Region: PRK09604 1205677009600 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1205677009601 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205677009602 Coenzyme A binding pocket [chemical binding]; other site 1205677009603 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1205677009604 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1205677009605 alanine racemase; Reviewed; Region: alr; PRK00053 1205677009606 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1205677009607 active site 1205677009608 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205677009609 dimer interface [polypeptide binding]; other site 1205677009610 substrate binding site [chemical binding]; other site 1205677009611 catalytic residues [active] 1205677009612 Evidence 4 : Homologs of previously reported genes of unknown function 1205677009613 Evidence 4 : Homologs of previously reported genes of unknown function 1205677009614 Evidence 4 : Homologs of previously reported genes of unknown function 1205677009615 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009616 PPE family; Region: PPE; pfam00823 1205677009617 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205677009618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677009619 Walker A motif; other site 1205677009620 ATP binding site [chemical binding]; other site 1205677009621 Walker B motif; other site 1205677009622 arginine finger; other site 1205677009623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205677009624 Integrase core domain; Region: rve; pfam00665 1205677009625 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009626 PPE family; Region: PPE; pfam00823 1205677009627 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677009628 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009629 PPE family; Region: PPE; pfam00823 1205677009630 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009631 PPE family; Region: PPE; pfam00823 1205677009632 Integrase core domain; Region: rve; pfam00665 1205677009633 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1205677009634 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205677009635 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205677009636 Integrase core domain; Region: rve_3; pfam13683 1205677009637 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1205677009638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677009639 catalytic residue [active] 1205677009640 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1205677009641 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1205677009642 putative substrate binding site [chemical binding]; other site 1205677009643 putative ATP binding site [chemical binding]; other site 1205677009644 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1205677009645 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1205677009646 glutaminase active site [active] 1205677009647 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1205677009648 dimer interface [polypeptide binding]; other site 1205677009649 active site 1205677009650 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1205677009651 dimer interface [polypeptide binding]; other site 1205677009652 active site 1205677009653 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1205677009654 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1205677009655 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1205677009656 active site 1205677009657 substrate binding site [chemical binding]; other site 1205677009658 metal binding site [ion binding]; metal-binding site 1205677009659 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1205677009660 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1205677009661 23S rRNA interface [nucleotide binding]; other site 1205677009662 L3 interface [polypeptide binding]; other site 1205677009663 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205677009664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677009665 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1205677009666 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205677009667 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677009668 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205677009669 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677009670 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677009671 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205677009672 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205677009673 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205677009674 active site 1205677009675 catalytic residues [active] 1205677009676 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205677009677 Cutinase; Region: Cutinase; pfam01083 1205677009678 Cutinase; Region: Cutinase; pfam01083 1205677009679 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1205677009680 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1205677009681 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1205677009682 dimerization interface 3.5A [polypeptide binding]; other site 1205677009683 active site 1205677009684 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1205677009685 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1205677009686 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1205677009687 alphaNTD - beta interaction site [polypeptide binding]; other site 1205677009688 alphaNTD homodimer interface [polypeptide binding]; other site 1205677009689 alphaNTD - beta' interaction site [polypeptide binding]; other site 1205677009690 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1205677009691 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1205677009692 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1205677009693 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205677009694 RNA binding surface [nucleotide binding]; other site 1205677009695 30S ribosomal protein S11; Validated; Region: PRK05309 1205677009696 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1205677009697 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1205677009698 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1205677009699 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1205677009700 rRNA binding site [nucleotide binding]; other site 1205677009701 predicted 30S ribosome binding site; other site 1205677009702 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1205677009703 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1205677009704 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1205677009705 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1205677009706 NAD binding site [chemical binding]; other site 1205677009707 substrate binding site [chemical binding]; other site 1205677009708 homodimer interface [polypeptide binding]; other site 1205677009709 active site 1205677009710 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1205677009711 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1205677009712 DDE superfamily endonuclease; Region: DDE_5; cl17874 1205677009713 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677009714 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677009715 active site 1205677009716 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205677009717 extended (e) SDRs; Region: SDR_e; cd08946 1205677009718 NAD(P) binding site [chemical binding]; other site 1205677009719 active site 1205677009720 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1205677009721 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1205677009722 active site 1205677009723 catalytic residues [active] 1205677009724 metal binding site [ion binding]; metal-binding site 1205677009725 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1205677009726 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205677009727 PYR/PP interface [polypeptide binding]; other site 1205677009728 dimer interface [polypeptide binding]; other site 1205677009729 TPP binding site [chemical binding]; other site 1205677009730 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205677009731 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1205677009732 TPP-binding site [chemical binding]; other site 1205677009733 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1205677009734 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1205677009735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677009736 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205677009737 Integrase core domain; Region: rve_3; pfam13683 1205677009738 HTH-like domain; Region: HTH_21; pfam13276 1205677009739 Transposase; Region: HTH_Tnp_1; pfam01527 1205677009740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205677009741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677009742 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205677009743 putative substrate translocation pore; other site 1205677009744 PE family; Region: PE; pfam00934 1205677009745 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009746 PPE family; Region: PPE; pfam00823 1205677009747 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677009748 patatin-related protein; Region: TIGR03607 1205677009749 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677009750 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677009751 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1205677009752 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205677009753 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1205677009754 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205677009755 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205677009756 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205677009757 short chain dehydrogenase; Provisional; Region: PRK05875 1205677009758 classical (c) SDRs; Region: SDR_c; cd05233 1205677009759 NAD(P) binding site [chemical binding]; other site 1205677009760 active site 1205677009761 Predicted membrane protein [Function unknown]; Region: COG2259 1205677009762 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205677009763 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205677009764 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205677009765 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205677009766 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1205677009767 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1205677009768 active site 1205677009769 homotetramer interface [polypeptide binding]; other site 1205677009770 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677009771 mce related protein; Region: MCE; pfam02470 1205677009772 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677009773 mce related protein; Region: MCE; pfam02470 1205677009774 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677009775 mce related protein; Region: MCE; pfam02470 1205677009776 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677009777 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677009778 mce related protein; Region: MCE; pfam02470 1205677009779 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677009780 mce related protein; Region: MCE; pfam02470 1205677009781 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677009782 mce related protein; Region: MCE; pfam02470 1205677009783 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205677009784 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677009785 Permease; Region: Permease; pfam02405 1205677009786 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677009787 Permease; Region: Permease; pfam02405 1205677009788 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1205677009789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677009790 NAD(P) binding site [chemical binding]; other site 1205677009791 active site 1205677009792 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205677009793 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205677009794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009795 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205677009796 FAD binding site [chemical binding]; other site 1205677009797 substrate binding site [chemical binding]; other site 1205677009798 catalytic base [active] 1205677009799 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009800 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205677009801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009802 active site 1205677009803 acyl-CoA synthetase; Validated; Region: PRK07867 1205677009804 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1205677009805 acyl-activating enzyme (AAE) consensus motif; other site 1205677009806 putative AMP binding site [chemical binding]; other site 1205677009807 putative active site [active] 1205677009808 putative CoA binding site [chemical binding]; other site 1205677009809 PE family; Region: PE; pfam00934 1205677009810 hypothetical protein; Validated; Region: PRK07586 1205677009811 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205677009812 PYR/PP interface [polypeptide binding]; other site 1205677009813 dimer interface [polypeptide binding]; other site 1205677009814 TPP binding site [chemical binding]; other site 1205677009815 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1205677009816 TPP-binding site [chemical binding]; other site 1205677009817 dimer interface [polypeptide binding]; other site 1205677009818 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205677009819 PE family; Region: PE; pfam00934 1205677009820 acyl-CoA synthetase; Validated; Region: PRK07798 1205677009821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677009822 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1205677009823 acyl-activating enzyme (AAE) consensus motif; other site 1205677009824 acyl-activating enzyme (AAE) consensus motif; other site 1205677009825 putative AMP binding site [chemical binding]; other site 1205677009826 putative active site [active] 1205677009827 putative CoA binding site [chemical binding]; other site 1205677009828 enoyl-CoA hydratase; Provisional; Region: PRK07799 1205677009829 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677009830 substrate binding site [chemical binding]; other site 1205677009831 oxyanion hole (OAH) forming residues; other site 1205677009832 trimer interface [polypeptide binding]; other site 1205677009833 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1205677009834 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15525680, 17652327 1205677009835 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15525680, 17652327 1205677009836 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677009837 Cytochrome P450; Region: p450; cl12078 1205677009838 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1205677009839 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205677009840 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1205677009841 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205677009842 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205677009843 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205677009844 lipid-transfer protein; Provisional; Region: PRK07937 1205677009845 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205677009846 active site 1205677009847 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1205677009848 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205677009849 active site 1205677009850 NHL repeat; Region: NHL; pfam01436 1205677009851 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205677009852 NHL repeat; Region: NHL; pfam01436 1205677009853 NHL repeat; Region: NHL; pfam01436 1205677009854 NHL repeat; Region: NHL; pfam01436 1205677009855 NHL repeat; Region: NHL; pfam01436 1205677009856 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1205677009857 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1205677009858 trimer interface [polypeptide binding]; other site 1205677009859 putative metal binding site [ion binding]; other site 1205677009860 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1205677009861 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1205677009862 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1205677009863 short chain dehydrogenase; Provisional; Region: PRK07890 1205677009864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677009865 NAD(P) binding site [chemical binding]; other site 1205677009866 active site 1205677009867 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009868 PPE family; Region: PPE; pfam00823 1205677009869 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205677009870 PPE family; Region: PPE; pfam00823 1205677009871 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009872 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009873 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1205677009874 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1205677009875 active site 1205677009876 catalytic residues [active] 1205677009877 metal binding site [ion binding]; metal-binding site 1205677009878 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1205677009879 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1205677009880 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205677009881 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1205677009882 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1205677009883 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1205677009884 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205677009885 enoyl-CoA hydratase; Region: PLN02864 1205677009886 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205677009887 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1205677009888 dimer interaction site [polypeptide binding]; other site 1205677009889 substrate-binding tunnel; other site 1205677009890 active site 1205677009891 catalytic site [active] 1205677009892 substrate binding site [chemical binding]; other site 1205677009893 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009894 PPE family; Region: PPE; pfam00823 1205677009895 PE-PPE domain; Region: PE-PPE; pfam08237 1205677009896 lipid-transfer protein; Provisional; Region: PRK07855 1205677009897 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205677009898 active site 1205677009899 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1205677009900 putative active site [active] 1205677009901 putative catalytic site [active] 1205677009902 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205677009903 active site 1205677009904 catalytic site [active] 1205677009905 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205677009906 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205677009907 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009908 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009909 active site 1205677009910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009911 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205677009912 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009913 active site 1205677009914 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677009915 Cytochrome P450; Region: p450; cl12078 1205677009916 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1205677009917 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205677009918 dimer interface [polypeptide binding]; other site 1205677009919 active site 1205677009920 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205677009921 short chain dehydrogenase; Provisional; Region: PRK07791 1205677009922 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1205677009923 homodimer interface [polypeptide binding]; other site 1205677009924 NAD binding site [chemical binding]; other site 1205677009925 active site 1205677009926 short chain dehydrogenase; Provisional; Region: PRK07856 1205677009927 classical (c) SDRs; Region: SDR_c; cd05233 1205677009928 NAD(P) binding site [chemical binding]; other site 1205677009929 active site 1205677009930 enoyl-CoA hydratase; Provisional; Region: PRK06495 1205677009931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677009932 substrate binding site [chemical binding]; other site 1205677009933 oxyanion hole (OAH) forming residues; other site 1205677009934 trimer interface [polypeptide binding]; other site 1205677009935 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1205677009936 Coenzyme A transferase; Region: CoA_trans; cl17247 1205677009937 Nitronate monooxygenase; Region: NMO; pfam03060 1205677009938 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205677009939 FMN binding site [chemical binding]; other site 1205677009940 substrate binding site [chemical binding]; other site 1205677009941 putative catalytic residue [active] 1205677009942 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205677009943 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1205677009944 putative di-iron ligands [ion binding]; other site 1205677009945 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1205677009946 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1205677009947 FAD binding pocket [chemical binding]; other site 1205677009948 FAD binding motif [chemical binding]; other site 1205677009949 phosphate binding motif [ion binding]; other site 1205677009950 beta-alpha-beta structure motif; other site 1205677009951 NAD(p) ribose binding residues [chemical binding]; other site 1205677009952 NAD binding pocket [chemical binding]; other site 1205677009953 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1205677009954 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677009955 catalytic loop [active] 1205677009956 iron binding site [ion binding]; other site 1205677009957 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205677009958 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1205677009959 putative active site [active] 1205677009960 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1205677009961 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205677009962 dimer interface [polypeptide binding]; other site 1205677009963 active site 1205677009964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677009965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677009966 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009967 PPE family; Region: PPE; pfam00823 1205677009968 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205677009969 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677009970 PPE family; Region: PPE; pfam00823 1205677009971 Integrase core domain; Region: rve; pfam00665 1205677009972 short chain dehydrogenase; Provisional; Region: PRK07831 1205677009973 classical (c) SDRs; Region: SDR_c; cd05233 1205677009974 NAD(P) binding site [chemical binding]; other site 1205677009975 active site 1205677009976 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009978 active site 1205677009979 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1205677009980 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205677009981 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1205677009982 acyl-activating enzyme (AAE) consensus motif; other site 1205677009983 acyl-activating enzyme (AAE) consensus motif; other site 1205677009984 putative AMP binding site [chemical binding]; other site 1205677009985 putative active site [active] 1205677009986 putative CoA binding site [chemical binding]; other site 1205677009987 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009988 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009989 active site 1205677009990 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205677009991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009992 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009993 active site 1205677009994 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677009995 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677009997 active site 1205677009998 aspartate aminotransferase; Provisional; Region: PRK05764 1205677009999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677010000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677010001 homodimer interface [polypeptide binding]; other site 1205677010002 catalytic residue [active] 1205677010003 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1205677010004 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205677010005 putative active site [active] 1205677010006 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1205677010007 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677010008 mce related protein; Region: MCE; pfam02470 1205677010009 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677010010 mce related protein; Region: MCE; pfam02470 1205677010011 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677010012 mce related protein; Region: MCE; pfam02470 1205677010013 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677010014 mce related protein; Region: MCE; pfam02470 1205677010015 mce related protein; Region: MCE; pfam02470 1205677010016 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205677010017 mce related protein; Region: MCE; pfam02470 1205677010018 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205677010019 Permease; Region: Permease; pfam02405 1205677010020 Permease; Region: Permease; pfam02405 1205677010021 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1205677010022 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205677010023 putative active site [active] 1205677010024 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205677010025 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1205677010026 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1205677010027 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1205677010028 active site 1205677010029 Fe binding site [ion binding]; other site 1205677010030 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1205677010031 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205677010032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677010033 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1205677010034 Flavin binding site [chemical binding]; other site 1205677010035 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205677010036 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1205677010037 FAD binding pocket [chemical binding]; other site 1205677010038 FAD binding motif [chemical binding]; other site 1205677010039 phosphate binding motif [ion binding]; other site 1205677010040 beta-alpha-beta structure motif; other site 1205677010041 NAD(p) ribose binding residues [chemical binding]; other site 1205677010042 NAD binding pocket [chemical binding]; other site 1205677010043 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1205677010044 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1205677010045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205677010046 catalytic loop [active] 1205677010047 iron binding site [ion binding]; other site 1205677010048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677010049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677010050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205677010051 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677010052 active site 1205677010053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677010054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677010055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205677010056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205677010057 DNA binding site [nucleotide binding] 1205677010058 domain linker motif; other site 1205677010059 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1205677010060 putative dimerization interface [polypeptide binding]; other site 1205677010061 putative ligand binding site [chemical binding]; other site 1205677010062 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677010063 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205677010064 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205677010065 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1205677010066 transmembrane helices; other site 1205677010067 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1205677010068 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1205677010069 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1205677010070 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205677010071 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1205677010072 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205677010073 active site 1205677010074 HIGH motif; other site 1205677010075 nucleotide binding site [chemical binding]; other site 1205677010076 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205677010077 KMSKS motif; other site 1205677010078 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1205677010079 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1205677010080 homotrimer interaction site [polypeptide binding]; other site 1205677010081 zinc binding site [ion binding]; other site 1205677010082 CDP-binding sites; other site 1205677010083 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1205677010084 substrate binding site; other site 1205677010085 dimer interface; other site 1205677010086 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1205677010087 DNA repair protein RadA; Provisional; Region: PRK11823 1205677010088 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1205677010089 Walker A motif/ATP binding site; other site 1205677010090 ATP binding site [chemical binding]; other site 1205677010091 Walker B motif; other site 1205677010092 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205677010093 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1205677010094 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1205677010095 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1205677010096 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1205677010097 active site clefts [active] 1205677010098 zinc binding site [ion binding]; other site 1205677010099 dimer interface [polypeptide binding]; other site 1205677010100 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205677010101 endonuclease III; Region: ENDO3c; smart00478 1205677010102 minor groove reading motif; other site 1205677010103 helix-hairpin-helix signature motif; other site 1205677010104 substrate binding pocket [chemical binding]; other site 1205677010105 active site 1205677010106 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1205677010107 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677010108 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205677010109 catalytic site [active] 1205677010110 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1205677010111 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1205677010112 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205677010113 Ami_2 domain; Region: Ami_2; smart00644 1205677010114 amidase catalytic site [active] 1205677010115 Zn binding residues [ion binding]; other site 1205677010116 substrate binding site [chemical binding]; other site 1205677010117 PE family; Region: PE; pfam00934 1205677010118 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1205677010119 Clp amino terminal domain; Region: Clp_N; pfam02861 1205677010120 Clp amino terminal domain; Region: Clp_N; pfam02861 1205677010121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677010122 Walker A motif; other site 1205677010123 ATP binding site [chemical binding]; other site 1205677010124 Walker B motif; other site 1205677010125 arginine finger; other site 1205677010126 UvrB/uvrC motif; Region: UVR; pfam02151 1205677010127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677010128 Walker A motif; other site 1205677010129 ATP binding site [chemical binding]; other site 1205677010130 Walker B motif; other site 1205677010131 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205677010132 Lsr2; Region: Lsr2; pfam11774 1205677010133 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1205677010134 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1205677010135 dimer interface [polypeptide binding]; other site 1205677010136 putative anticodon binding site; other site 1205677010137 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205677010138 motif 1; other site 1205677010139 dimer interface [polypeptide binding]; other site 1205677010140 active site 1205677010141 motif 2; other site 1205677010142 motif 3; other site 1205677010143 pantothenate kinase; Reviewed; Region: PRK13318 1205677010144 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1205677010145 tetramerization interface [polypeptide binding]; other site 1205677010146 active site 1205677010147 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1205677010148 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1205677010149 active site 1205677010150 ATP-binding site [chemical binding]; other site 1205677010151 pantoate-binding site; other site 1205677010152 HXXH motif; other site 1205677010153 Rossmann-like domain; Region: Rossmann-like; pfam10727 1205677010154 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1205677010155 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1205677010156 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1205677010157 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1205677010158 catalytic center binding site [active] 1205677010159 ATP binding site [chemical binding]; other site 1205677010160 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1205677010161 homooctamer interface [polypeptide binding]; other site 1205677010162 active site 1205677010163 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1205677010164 dihydropteroate synthase; Region: DHPS; TIGR01496 1205677010165 substrate binding pocket [chemical binding]; other site 1205677010166 dimer interface [polypeptide binding]; other site 1205677010167 inhibitor binding site; inhibition site 1205677010168 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1205677010169 homodecamer interface [polypeptide binding]; other site 1205677010170 GTP cyclohydrolase I; Provisional; Region: PLN03044 1205677010171 active site 1205677010172 putative catalytic site residues [active] 1205677010173 zinc binding site [ion binding]; other site 1205677010174 GTP-CH-I/GFRP interaction surface; other site 1205677010175 FtsH Extracellular; Region: FtsH_ext; pfam06480 1205677010176 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1205677010177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677010178 Walker A motif; other site 1205677010179 ATP binding site [chemical binding]; other site 1205677010180 Walker B motif; other site 1205677010181 arginine finger; other site 1205677010182 Peptidase family M41; Region: Peptidase_M41; pfam01434 1205677010183 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205677010184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677010185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205677010186 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205677010187 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205677010188 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205677010189 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205677010190 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677010191 PPE family; Region: PPE; pfam00823 1205677010192 PE family; Region: PE; pfam00934 1205677010193 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1205677010194 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1205677010195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205677010196 active site 1205677010197 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1205677010198 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1205677010199 Ligand Binding Site [chemical binding]; other site 1205677010200 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1205677010201 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205677010202 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1205677010203 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1205677010204 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1205677010205 dimer interface [polypeptide binding]; other site 1205677010206 substrate binding site [chemical binding]; other site 1205677010207 metal binding sites [ion binding]; metal-binding site 1205677010208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1205677010209 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1205677010210 Ligand binding site; other site 1205677010211 Putative Catalytic site; other site 1205677010212 DXD motif; other site 1205677010213 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1205677010214 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1205677010215 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205677010216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677010217 NAD(P) binding site [chemical binding]; other site 1205677010218 active site 1205677010219 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pcp : putative cell process 1205677010220 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pcp : putative cell process 1205677010221 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1205677010222 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1205677010223 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 1205677010224 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1205677010225 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1205677010226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205677010227 dimerization interface [polypeptide binding]; other site 1205677010228 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205677010229 cyclase homology domain; Region: CHD; cd07302 1205677010230 nucleotidyl binding site; other site 1205677010231 metal binding site [ion binding]; metal-binding site 1205677010232 dimer interface [polypeptide binding]; other site 1205677010233 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1205677010234 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1205677010235 active site 1205677010236 interdomain interaction site; other site 1205677010237 putative metal-binding site [ion binding]; other site 1205677010238 nucleotide binding site [chemical binding]; other site 1205677010239 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1205677010240 domain I; other site 1205677010241 phosphate binding site [ion binding]; other site 1205677010242 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1205677010243 domain II; other site 1205677010244 domain III; other site 1205677010245 nucleotide binding site [chemical binding]; other site 1205677010246 DNA binding groove [nucleotide binding] 1205677010247 catalytic site [active] 1205677010248 domain IV; other site 1205677010249 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205677010250 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205677010251 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205677010252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205677010253 DNA-binding site [nucleotide binding]; DNA binding site 1205677010254 RNA-binding motif; other site 1205677010255 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1205677010256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205677010257 ATP binding site [chemical binding]; other site 1205677010258 putative Mg++ binding site [ion binding]; other site 1205677010259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205677010260 nucleotide binding region [chemical binding]; other site 1205677010261 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1205677010262 PE family; Region: PE; pfam00934 1205677010263 PE family; Region: PE; pfam00934 1205677010264 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1205677010265 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1205677010266 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1205677010267 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1205677010268 Walker A motif; other site 1205677010269 hexamer interface [polypeptide binding]; other site 1205677010270 ATP binding site [chemical binding]; other site 1205677010271 Walker B motif; other site 1205677010272 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1205677010273 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205677010274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677010275 motif II; other site 1205677010276 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1205677010277 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205677010278 Walker A/P-loop; other site 1205677010279 ATP binding site [chemical binding]; other site 1205677010280 Q-loop/lid; other site 1205677010281 ABC transporter signature motif; other site 1205677010282 Walker B; other site 1205677010283 D-loop; other site 1205677010284 H-loop/switch region; other site 1205677010285 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205677010286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205677010287 Walker A/P-loop; other site 1205677010288 ATP binding site [chemical binding]; other site 1205677010289 Q-loop/lid; other site 1205677010290 ABC transporter signature motif; other site 1205677010291 Walker B; other site 1205677010292 D-loop; other site 1205677010293 H-loop/switch region; other site 1205677010294 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205677010295 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1205677010296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677010297 ABC-ATPase subunit interface; other site 1205677010298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205677010299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677010300 dimer interface [polypeptide binding]; other site 1205677010301 conserved gate region; other site 1205677010302 ABC-ATPase subunit interface; other site 1205677010303 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1205677010304 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1205677010305 acetyl-CoA synthetase; Provisional; Region: PRK00174 1205677010306 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1205677010307 active site 1205677010308 CoA binding site [chemical binding]; other site 1205677010309 acyl-activating enzyme (AAE) consensus motif; other site 1205677010310 AMP binding site [chemical binding]; other site 1205677010311 acetate binding site [chemical binding]; other site 1205677010312 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1205677010313 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205677010314 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205677010315 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1205677010316 putative active site [active] 1205677010317 putative CoA binding site [chemical binding]; other site 1205677010318 nudix motif; other site 1205677010319 metal binding site [ion binding]; metal-binding site 1205677010320 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1205677010321 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205677010322 catalytic residues [active] 1205677010323 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1205677010324 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205677010325 minor groove reading motif; other site 1205677010326 helix-hairpin-helix signature motif; other site 1205677010327 substrate binding pocket [chemical binding]; other site 1205677010328 active site 1205677010329 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1205677010330 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677010331 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677010332 ligand binding site [chemical binding]; other site 1205677010333 flexible hinge region; other site 1205677010334 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205677010335 putative switch regulator; other site 1205677010336 non-specific DNA interactions [nucleotide binding]; other site 1205677010337 DNA binding site [nucleotide binding] 1205677010338 sequence specific DNA binding site [nucleotide binding]; other site 1205677010339 putative cAMP binding site [chemical binding]; other site 1205677010340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205677010341 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1205677010342 homotrimer interaction site [polypeptide binding]; other site 1205677010343 putative active site [active] 1205677010344 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1205677010345 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205677010346 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205677010347 P loop; other site 1205677010348 Nucleotide binding site [chemical binding]; other site 1205677010349 DTAP/Switch II; other site 1205677010350 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205677010351 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205677010352 DTAP/Switch II; other site 1205677010353 Switch I; other site 1205677010354 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205677010355 Transcription factor WhiB; Region: Whib; pfam02467 1205677010356 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1205677010357 Transglycosylase; Region: Transgly; pfam00912 1205677010358 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205677010359 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205677010360 phosphodiesterase YaeI; Provisional; Region: PRK11340 1205677010361 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1205677010362 putative active site [active] 1205677010363 putative metal binding site [ion binding]; other site 1205677010364 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205677010365 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205677010366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677010367 catalytic residue [active] 1205677010368 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205677010369 Cytochrome P450; Region: p450; cl12078 1205677010370 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205677010371 anti sigma factor interaction site; other site 1205677010372 regulatory phosphorylation site [posttranslational modification]; other site 1205677010373 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1205677010374 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1205677010375 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1205677010376 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205677010377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677010378 Walker A motif; other site 1205677010379 ATP binding site [chemical binding]; other site 1205677010380 Walker B motif; other site 1205677010381 arginine finger; other site 1205677010382 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205677010383 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205677010384 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1205677010385 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1205677010386 glycerol kinase; Provisional; Region: glpK; PRK00047 1205677010387 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205677010388 nucleotide binding site [chemical binding]; other site 1205677010389 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205677010390 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205677010391 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205677010392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677010393 S-adenosylmethionine binding site [chemical binding]; other site 1205677010394 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205677010395 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205677010396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677010397 catalytic residue [active] 1205677010398 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1205677010399 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1205677010400 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1205677010401 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1205677010402 putative active site [active] 1205677010403 putative dimer interface [polypeptide binding]; other site 1205677010404 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1205677010405 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1205677010406 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205677010407 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205677010408 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1205677010409 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1205677010410 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205677010411 aspartate kinase; Reviewed; Region: PRK06635 1205677010412 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1205677010413 putative nucleotide binding site [chemical binding]; other site 1205677010414 putative catalytic residues [active] 1205677010415 putative Mg ion binding site [ion binding]; other site 1205677010416 putative aspartate binding site [chemical binding]; other site 1205677010417 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1205677010418 putative allosteric regulatory site; other site 1205677010419 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1205677010420 putative allosteric regulatory residue; other site 1205677010421 2-isopropylmalate synthase; Validated; Region: PRK03739 1205677010422 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1205677010423 active site 1205677010424 catalytic residues [active] 1205677010425 metal binding site [ion binding]; metal-binding site 1205677010426 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1205677010427 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1205677010428 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205677010429 active site 1205677010430 catalytic site [active] 1205677010431 substrate binding site [chemical binding]; other site 1205677010432 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1205677010433 Dimer interface [polypeptide binding]; other site 1205677010434 BRCT sequence motif; other site 1205677010435 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1205677010436 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1205677010437 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205677010438 catalytic triad [active] 1205677010439 recombination protein RecR; Reviewed; Region: recR; PRK00076 1205677010440 RecR protein; Region: RecR; pfam02132 1205677010441 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1205677010442 putative active site [active] 1205677010443 putative metal-binding site [ion binding]; other site 1205677010444 tetramer interface [polypeptide binding]; other site 1205677010445 hypothetical protein; Validated; Region: PRK00153 1205677010446 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1205677010447 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1205677010448 active site 1205677010449 metal binding site [ion binding]; metal-binding site 1205677010450 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1205677010451 hydrophobic ligand binding site; other site 1205677010452 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677010453 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677010454 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205677010455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677010456 S-adenosylmethionine binding site [chemical binding]; other site 1205677010457 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1205677010458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677010459 Walker A motif; other site 1205677010460 ATP binding site [chemical binding]; other site 1205677010461 Walker B motif; other site 1205677010462 arginine finger; other site 1205677010463 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1205677010464 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1205677010465 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205677010466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677010467 catalytic residue [active] 1205677010468 Cutinase; Region: Cutinase; pfam01083 1205677010469 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1205677010470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677010471 NAD(P) binding site [chemical binding]; other site 1205677010472 active site 1205677010473 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205677010474 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1205677010475 putative NAD(P) binding site [chemical binding]; other site 1205677010476 catalytic Zn binding site [ion binding]; other site 1205677010477 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1205677010478 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1205677010479 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205677010480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205677010481 putative substrate translocation pore; other site 1205677010482 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205677010483 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205677010484 ligand binding site [chemical binding]; other site 1205677010485 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205677010486 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205677010487 active site 1205677010488 nucleophile elbow; other site 1205677010489 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1205677010490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205677010491 FeS/SAM binding site; other site 1205677010492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205677010493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677010494 S-adenosylmethionine binding site [chemical binding]; other site 1205677010495 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1205677010496 nucleotide binding site [chemical binding]; other site 1205677010497 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1205677010498 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1205677010499 active site 1205677010500 DNA binding site [nucleotide binding] 1205677010501 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1205677010502 DNA binding site [nucleotide binding] 1205677010503 Evidence 4 : Homologs of previously reported genes of unknown function 1205677010504 Evidence 4 : Homologs of previously reported genes of unknown function 1205677010505 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1205677010506 nudix motif; other site 1205677010507 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677010508 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677010509 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1205677010510 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205677010511 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205677010512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205677010513 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1205677010514 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1205677010515 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1205677010516 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677010517 PPE family; Region: PPE; pfam00823 1205677010518 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205677010519 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205677010520 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1205677010521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205677010522 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205677010523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205677010524 dimerization interface [polypeptide binding]; other site 1205677010525 putative DNA binding site [nucleotide binding]; other site 1205677010526 putative Zn2+ binding site [ion binding]; other site 1205677010527 PIN domain; Region: PIN_3; pfam13470 1205677010528 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205677010529 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205677010530 DNA binding site [nucleotide binding] 1205677010531 active site 1205677010532 Int/Topo IB signature motif; other site 1205677010533 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205677010534 nucleoside/Zn binding site; other site 1205677010535 dimer interface [polypeptide binding]; other site 1205677010536 catalytic motif [active] 1205677010537 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1205677010538 prephenate dehydrogenase; Validated; Region: PRK06545 1205677010539 prephenate dehydrogenase; Validated; Region: PRK08507 1205677010540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1205677010541 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1205677010542 ABC-ATPase subunit interface; other site 1205677010543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205677010544 dimer interface [polypeptide binding]; other site 1205677010545 conserved gate region; other site 1205677010546 ABC-ATPase subunit interface; other site 1205677010547 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1205677010548 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1205677010549 Walker A/P-loop; other site 1205677010550 ATP binding site [chemical binding]; other site 1205677010551 Q-loop/lid; other site 1205677010552 ABC transporter signature motif; other site 1205677010553 Walker B; other site 1205677010554 D-loop; other site 1205677010555 H-loop/switch region; other site 1205677010556 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1205677010557 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1205677010558 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1205677010559 putative active site [active] 1205677010560 putative substrate binding site [chemical binding]; other site 1205677010561 ATP binding site [chemical binding]; other site 1205677010562 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1205677010563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205677010564 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1205677010565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205677010566 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1205677010567 dimerization interface [polypeptide binding]; other site 1205677010568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205677010569 dimer interface [polypeptide binding]; other site 1205677010570 phosphorylation site [posttranslational modification] 1205677010571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205677010572 ATP binding site [chemical binding]; other site 1205677010573 Mg2+ binding site [ion binding]; other site 1205677010574 G-X-G motif; other site 1205677010575 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205677010576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205677010577 active site 1205677010578 phosphorylation site [posttranslational modification] 1205677010579 intermolecular recognition site; other site 1205677010580 dimerization interface [polypeptide binding]; other site 1205677010581 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205677010582 DNA binding site [nucleotide binding] 1205677010583 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205677010584 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205677010585 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677010586 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677010587 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205677010588 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1205677010589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205677010590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205677010591 homodimer interface [polypeptide binding]; other site 1205677010592 catalytic residue [active] 1205677010593 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205677010594 TIGR03086 family protein; Region: TIGR03086 1205677010595 enoyl-CoA hydratase; Provisional; Region: PRK06142 1205677010596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205677010597 substrate binding site [chemical binding]; other site 1205677010598 oxyanion hole (OAH) forming residues; other site 1205677010599 trimer interface [polypeptide binding]; other site 1205677010600 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205677010601 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205677010602 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205677010603 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205677010604 active site 1205677010605 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1205677010606 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1205677010607 NAD(P) binding site [chemical binding]; other site 1205677010608 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205677010609 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1205677010610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205677010611 catalytic residue [active] 1205677010612 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1205677010613 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1205677010614 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1205677010615 Walker A/P-loop; other site 1205677010616 ATP binding site [chemical binding]; other site 1205677010617 Q-loop/lid; other site 1205677010618 ABC transporter signature motif; other site 1205677010619 Walker B; other site 1205677010620 D-loop; other site 1205677010621 H-loop/switch region; other site 1205677010622 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205677010623 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205677010624 active site 1205677010625 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1205677010626 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205677010627 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205677010628 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1205677010629 NAD binding site [chemical binding]; other site 1205677010630 substrate binding site [chemical binding]; other site 1205677010631 active site 1205677010632 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205677010633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205677010634 active site 1205677010635 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205677010636 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205677010637 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205677010638 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205677010639 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1205677010640 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205677010641 Predicted membrane protein [Function unknown]; Region: COG2246 1205677010642 GtrA-like protein; Region: GtrA; pfam04138 1205677010643 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205677010644 FAD binding domain; Region: FAD_binding_4; pfam01565 1205677010645 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205677010646 short chain dehydrogenase; Provisional; Region: PRK07904 1205677010647 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205677010648 NAD(P) binding site [chemical binding]; other site 1205677010649 active site 1205677010650 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1205677010651 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1205677010652 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205677010653 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205677010654 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205677010655 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205677010656 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1205677010657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205677010658 FAD binding site [chemical binding]; other site 1205677010659 substrate binding site [chemical binding]; other site 1205677010660 catalytic residues [active] 1205677010661 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205677010662 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205677010663 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205677010664 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677010665 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677010666 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205677010667 active site 1205677010668 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205677010669 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677010670 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677010671 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1205677010672 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1205677010673 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677010674 acyl-activating enzyme (AAE) consensus motif; other site 1205677010675 active site 1205677010676 Cutinase; Region: Cutinase; pfam01083 1205677010677 Predicted esterase [General function prediction only]; Region: COG0627 1205677010678 Putative esterase; Region: Esterase; pfam00756 1205677010679 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1205677010680 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1205677010681 active site 1205677010682 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205677010683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1205677010684 active site 1205677010685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205677010686 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1205677010687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677010688 UDP-galactopyranose mutase; Region: GLF; pfam03275 1205677010689 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1205677010690 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205677010691 amidase catalytic site [active] 1205677010692 Zn binding residues [ion binding]; other site 1205677010693 substrate binding site [chemical binding]; other site 1205677010694 LGFP repeat; Region: LGFP; pfam08310 1205677010695 PE family; Region: PE; pfam00934 1205677010696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205677010697 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1205677010698 active site 1205677010699 motif I; other site 1205677010700 motif II; other site 1205677010701 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205677010702 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677010703 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205677010704 putative acyl-acceptor binding pocket; other site 1205677010705 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677010706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205677010707 putative acyl-acceptor binding pocket; other site 1205677010708 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205677010709 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205677010710 putative acyl-acceptor binding pocket; other site 1205677010711 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1205677010712 Phosphotransferase enzyme family; Region: APH; pfam01636 1205677010713 active site 1205677010714 ATP binding site [chemical binding]; other site 1205677010715 antibiotic binding site [chemical binding]; other site 1205677010716 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205677010717 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205677010718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205677010719 dimerization interface [polypeptide binding]; other site 1205677010720 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1205677010721 iron-sulfur cluster [ion binding]; other site 1205677010722 [2Fe-2S] cluster binding site [ion binding]; other site 1205677010723 Condensation domain; Region: Condensation; pfam00668 1205677010724 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205677010725 PE-PPE domain; Region: PE-PPE; pfam08237 1205677010726 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205677010727 peptide synthase; Provisional; Region: PRK12316 1205677010728 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205677010729 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205677010730 active site 1205677010731 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205677010732 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205677010733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205677010734 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205677010735 Enoylreductase; Region: PKS_ER; smart00829 1205677010736 NAD(P) binding site [chemical binding]; other site 1205677010737 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205677010738 KR domain; Region: KR; pfam08659 1205677010739 putative NADP binding site [chemical binding]; other site 1205677010740 active site 1205677010741 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205677010742 acyl-CoA synthetase; Validated; Region: PRK05850 1205677010743 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205677010744 acyl-activating enzyme (AAE) consensus motif; other site 1205677010745 active site 1205677010746 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205677010747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677010748 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205677010749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677010750 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1205677010751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205677010752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205677010753 Cupin domain; Region: Cupin_2; cl17218 1205677010754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205677010755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205677010756 seryl-tRNA synthetase; Provisional; Region: PRK05431 1205677010757 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1205677010758 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1205677010759 dimer interface [polypeptide binding]; other site 1205677010760 active site 1205677010761 motif 1; other site 1205677010762 motif 2; other site 1205677010763 motif 3; other site 1205677010764 Septum formation; Region: Septum_form; pfam13845 1205677010765 Septum formation; Region: Septum_form; pfam13845 1205677010766 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1205677010767 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205677010768 catalytic core [active] 1205677010769 prephenate dehydratase; Provisional; Region: PRK11898 1205677010770 Prephenate dehydratase; Region: PDT; pfam00800 1205677010771 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1205677010772 putative L-Phe binding site [chemical binding]; other site 1205677010773 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1205677010774 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205677010775 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1205677010776 Ferritin-like domain; Region: Ferritin; pfam00210 1205677010777 ferroxidase diiron center [ion binding]; other site 1205677010778 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1205677010779 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205677010780 putative active site [active] 1205677010781 catalytic site [active] 1205677010782 putative metal binding site [ion binding]; other site 1205677010783 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1205677010784 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205677010785 Evidence 4 : Homologs of previously reported genes of unknown function 1205677010786 Evidence 4 : Homologs of previously reported genes of unknown function 1205677010787 HTH-like domain; Region: HTH_21; pfam13276 1205677010788 Integrase core domain; Region: rve; pfam00665 1205677010789 Integrase core domain; Region: rve_3; pfam13683 1205677010790 Transposase; Region: HTH_Tnp_1; pfam01527 1205677010791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205677010792 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1205677010793 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1205677010794 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1205677010795 Predicted membrane protein [Function unknown]; Region: COG2119 1205677010796 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1205677010797 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1205677010798 Fimbrial protein; Region: Fimbrial; cl01416 1205677010799 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1205677010800 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205677010801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205677010802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205677010803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205677010804 hypothetical protein; Provisional; Region: PRK07945 1205677010805 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1205677010806 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1205677010807 active site 1205677010808 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1205677010809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205677010810 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1205677010811 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1205677010812 active site 1205677010813 dimer interface [polypeptide binding]; other site 1205677010814 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1205677010815 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1205677010816 active site 1205677010817 FMN binding site [chemical binding]; other site 1205677010818 substrate binding site [chemical binding]; other site 1205677010819 3Fe-4S cluster binding site [ion binding]; other site 1205677010820 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1205677010821 domain interface; other site 1205677010822 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205677010823 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205677010824 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205677010825 EspG family; Region: ESX-1_EspG; pfam14011 1205677010826 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205677010827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677010828 Walker A motif; other site 1205677010829 ATP binding site [chemical binding]; other site 1205677010830 Walker B motif; other site 1205677010831 arginine finger; other site 1205677010832 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205677010833 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205677010834 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677010835 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205677010836 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677010837 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677010838 PE family; Region: PE; pfam00934 1205677010839 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205677010840 PPE family; Region: PPE; pfam00823 1205677010841 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205677010842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677010843 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205677010844 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205677010845 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1205677010846 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205677010847 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205677010848 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205677010849 active site 1205677010850 catalytic residues [active] 1205677010851 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205677010852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205677010853 Walker A motif; other site 1205677010854 ATP binding site [chemical binding]; other site 1205677010855 Walker B motif; other site 1205677010856 arginine finger; other site 1205677010857 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205677010858 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205677010859 catalytic residues [active] 1205677010860 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205677010861 active site 1205677010862 catalytic residues [active] 1205677010863 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205677010864 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205677010865 EspG family; Region: ESX-1_EspG; pfam14011 1205677010866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677010867 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205677010868 PPE family; Region: PPE; pfam00823 1205677010869 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205677010870 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677010871 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205677010872 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677010873 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205677010874 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205677010875 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205677010876 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205677010877 catalytic residue [active] 1205677010878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205677010879 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1205677010880 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1205677010881 active site 1205677010882 NTP binding site [chemical binding]; other site 1205677010883 metal binding triad [ion binding]; metal-binding site 1205677010884 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1205677010885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205677010886 Zn2+ binding site [ion binding]; other site 1205677010887 Mg2+ binding site [ion binding]; other site 1205677010888 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1205677010889 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1205677010890 active site 1205677010891 Ap6A binding site [chemical binding]; other site 1205677010892 nudix motif; other site 1205677010893 metal binding site [ion binding]; metal-binding site 1205677010894 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1205677010895 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1205677010896 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1205677010897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205677010898 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205677010899 DNA binding residues [nucleotide binding] 1205677010900 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1205677010901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205677010902 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205677010903 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205677010904 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205677010905 catalytic residues [active] 1205677010906 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1205677010907 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205677010908 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205677010909 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1205677010910 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1205677010911 active site 1205677010912 metal binding site [ion binding]; metal-binding site 1205677010913 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1205677010914 ParB-like nuclease domain; Region: ParB; smart00470 1205677010915 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205677010916 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205677010917 P-loop; other site 1205677010918 Magnesium ion binding site [ion binding]; other site 1205677010919 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205677010920 Magnesium ion binding site [ion binding]; other site 1205677010921 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1205677010922 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1205677010923 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1205677010924 G-X-X-G motif; other site 1205677010925 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1205677010926 RxxxH motif; other site 1205677010927 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1205677010928 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1205677010929 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1205677010930 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399