-- dump date 20140619_152028 -- class Genbank::misc_feature -- table misc_feature_note -- id note 710421000001 adenylate kinase; Reviewed; Region: adk; PRK00279 710421000002 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710421000003 AMP-binding site [chemical binding]; other site 710421000004 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710421000005 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 710421000006 conserved cys residue [active] 710421000007 Helix-turn-helix domain; Region: HTH_18; pfam12833 710421000008 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 710421000009 Transposase; Region: HTH_Tnp_1; pfam01527 710421000010 HTH-like domain; Region: HTH_21; pfam13276 710421000011 Integrase core domain; Region: rve; pfam00665 710421000012 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421000013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421000014 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421000015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421000016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 710421000017 DNA-binding site [nucleotide binding]; DNA binding site 710421000018 Integrase core domain; Region: rve; pfam00665 710421000019 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710421000020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421000021 Walker A motif; other site 710421000022 ATP binding site [chemical binding]; other site 710421000023 Walker B motif; other site 710421000024 arginine finger; other site 710421000025 TrwC relaxase; Region: TrwC; pfam08751 710421000026 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 710421000027 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 710421000028 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 710421000029 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 710421000030 Peptidase family M48; Region: Peptidase_M48; cl12018 710421000031 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000032 active site 710421000033 DNA binding site [nucleotide binding] 710421000034 Int/Topo IB signature motif; other site 710421000035 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710421000036 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000037 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000038 active site 710421000039 DNA binding site [nucleotide binding] 710421000040 Int/Topo IB signature motif; other site 710421000041 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 710421000042 ParB-like nuclease domain; Region: ParB; smart00470 710421000043 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421000044 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710421000045 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710421000046 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 710421000047 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 710421000048 ParB-like nuclease domain; Region: ParBc; pfam02195 710421000049 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 710421000050 Catalytic site; other site 710421000051 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 710421000052 putative active site [active] 710421000053 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710421000054 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421000055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421000056 non-specific DNA binding site [nucleotide binding]; other site 710421000057 salt bridge; other site 710421000058 sequence-specific DNA binding site [nucleotide binding]; other site 710421000059 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000060 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710421000061 active site 710421000062 DNA binding site [nucleotide binding] 710421000063 Int/Topo IB signature motif; other site 710421000064 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710421000065 MULE transposase domain; Region: MULE; pfam10551 710421000066 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 710421000067 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 710421000068 DNA protecting protein DprA; Region: dprA; TIGR00732 710421000069 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 710421000070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421000071 active site 710421000072 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710421000073 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 710421000074 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 710421000075 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710421000076 active site 710421000077 catalytic residues [active] 710421000078 DNA binding site [nucleotide binding] 710421000079 Int/Topo IB signature motif; other site 710421000080 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 710421000081 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710421000082 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710421000083 ring oligomerisation interface [polypeptide binding]; other site 710421000084 ATP/Mg binding site [chemical binding]; other site 710421000085 stacking interactions; other site 710421000086 hinge regions; other site 710421000087 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710421000088 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710421000089 NAD binding site [chemical binding]; other site 710421000090 catalytic Zn binding site [ion binding]; other site 710421000091 substrate binding site [chemical binding]; other site 710421000092 structural Zn binding site [ion binding]; other site 710421000093 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710421000094 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421000095 catalytic loop [active] 710421000096 iron binding site [ion binding]; other site 710421000097 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710421000098 FAD binding pocket [chemical binding]; other site 710421000099 conserved FAD binding motif [chemical binding]; other site 710421000100 phosphate binding motif [ion binding]; other site 710421000101 beta-alpha-beta structure motif; other site 710421000102 NAD binding pocket [chemical binding]; other site 710421000103 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710421000104 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 710421000105 dimerization interface [polypeptide binding]; other site 710421000106 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 710421000107 dimerization interface [polypeptide binding]; other site 710421000108 putative path to active site cavity [active] 710421000109 diiron center [ion binding]; other site 710421000110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421000111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421000112 DNA binding residues [nucleotide binding] 710421000113 dimerization interface [polypeptide binding]; other site 710421000114 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710421000115 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 710421000116 ATP binding site [chemical binding]; other site 710421000117 Mg2+ binding site [ion binding]; other site 710421000118 G-X-G motif; other site 710421000119 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710421000120 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 710421000121 active site 710421000122 NAD binding site [chemical binding]; other site 710421000123 metal binding site [ion binding]; metal-binding site 710421000124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421000125 Histidine kinase; Region: HisKA_3; pfam07730 710421000126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421000127 ATP binding site [chemical binding]; other site 710421000128 Mg2+ binding site [ion binding]; other site 710421000129 G-X-G motif; other site 710421000130 Staphylococcal nuclease homologues; Region: SNc; smart00318 710421000131 Catalytic site; other site 710421000132 Staphylococcal nuclease homologue; Region: SNase; pfam00565 710421000133 PemK-like protein; Region: PemK; pfam02452 710421000134 PemK-like protein; Region: PemK; pfam02452 710421000135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000136 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421000137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421000138 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421000139 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 710421000140 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 710421000141 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710421000142 active site 710421000143 catalytic residues [active] 710421000144 DNA binding site [nucleotide binding] 710421000145 Int/Topo IB signature motif; other site 710421000146 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710421000147 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 710421000148 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 710421000149 ATP binding site [chemical binding]; other site 710421000150 substrate interface [chemical binding]; other site 710421000151 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 710421000152 Domain of unknown function (DUF955); Region: DUF955; cl01076 710421000153 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710421000154 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421000155 PAS fold; Region: PAS_2; pfam08446 710421000156 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 710421000157 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 710421000158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421000159 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421000160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421000161 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710421000162 Walker A motif; other site 710421000163 ATP binding site [chemical binding]; other site 710421000164 Walker B motif; other site 710421000165 Helix-turn-helix domain; Region: HTH_36; pfam13730 710421000166 Abi-like protein; Region: Abi_2; pfam07751 710421000167 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710421000168 activation loop (A-loop); other site 710421000169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710421000170 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 710421000171 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710421000172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421000173 active site 710421000174 metal binding site [ion binding]; metal-binding site 710421000175 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 710421000176 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 710421000177 potential catalytic triad [active] 710421000178 conserved cys residue [active] 710421000179 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421000180 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 710421000181 putative catalytic cysteine [active] 710421000182 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710421000183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000185 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000186 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421000187 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710421000188 argininosuccinate lyase; Region: argH; TIGR00838 710421000189 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710421000190 tetramer interface [polypeptide binding]; other site 710421000191 D-cysteine desulfhydrase; Validated; Region: PRK03910 710421000192 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710421000193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421000194 catalytic residue [active] 710421000195 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 710421000196 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 710421000197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000200 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710421000201 classical (c) SDRs; Region: SDR_c; cd05233 710421000202 NAD(P) binding site [chemical binding]; other site 710421000203 active site 710421000204 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710421000205 classical (c) SDRs; Region: SDR_c; cd05233 710421000206 NAD(P) binding site [chemical binding]; other site 710421000207 active site 710421000208 Coenzyme A transferase; Region: CoA_trans; cl17247 710421000209 Coenzyme A transferase; Region: CoA_trans; cl17247 710421000210 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 710421000211 CoA binding domain; Region: CoA_binding_2; pfam13380 710421000212 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 710421000213 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710421000214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000216 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000217 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710421000218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421000219 catalytic loop [active] 710421000220 iron binding site [ion binding]; other site 710421000221 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710421000222 FAD binding pocket [chemical binding]; other site 710421000223 conserved FAD binding motif [chemical binding]; other site 710421000224 phosphate binding motif [ion binding]; other site 710421000225 beta-alpha-beta structure motif; other site 710421000226 NAD binding pocket [chemical binding]; other site 710421000227 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 710421000228 dimerization interface [polypeptide binding]; other site 710421000229 putative path to active site cavity [active] 710421000230 diiron center [ion binding]; other site 710421000231 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710421000232 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710421000233 dinuclear metal binding motif [ion binding]; other site 710421000234 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421000235 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710421000236 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 710421000237 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA [Energy production and conversion]; Region: NqrA; COG1726 710421000238 TrwC relaxase; Region: TrwC; pfam08751 710421000239 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 710421000240 AAA domain; Region: AAA_30; pfam13604 710421000241 Family description; Region: UvrD_C_2; pfam13538 710421000242 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 710421000243 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710421000244 catalytic residues [active] 710421000245 H+ Antiporter protein; Region: 2A0121; TIGR00900 710421000246 Transmembrane secretion effector; Region: MFS_3; pfam05977 710421000247 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 710421000248 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 710421000249 DNA binding residues [nucleotide binding] 710421000250 dimer interface [polypeptide binding]; other site 710421000251 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421000252 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710421000253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421000254 dimerization interface [polypeptide binding]; other site 710421000255 putative DNA binding site [nucleotide binding]; other site 710421000256 putative Zn2+ binding site [ion binding]; other site 710421000257 mercuric reductase; Region: MerA; TIGR02053 710421000258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000259 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000260 alkylmercury lyase; Provisional; Region: PRK13239 710421000261 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 710421000262 Alkylmercury lyase; Region: MerB; pfam03243 710421000263 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710421000264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000266 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000268 active site 710421000269 Int/Topo IB signature motif; other site 710421000270 DNA binding site [nucleotide binding] 710421000271 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710421000272 DNA binding site [nucleotide binding] 710421000273 active site 710421000274 Int/Topo IB signature motif; other site 710421000275 catalytic residues [active] 710421000276 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 710421000277 ParB-like nuclease domain; Region: ParBc; pfam02195 710421000278 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710421000279 catalytic residues [active] 710421000280 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 710421000281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000282 active site 710421000283 DNA binding site [nucleotide binding] 710421000284 Int/Topo IB signature motif; other site 710421000285 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 710421000286 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 710421000287 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710421000288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421000289 Walker A motif; other site 710421000290 ATP binding site [chemical binding]; other site 710421000291 Walker B motif; other site 710421000292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421000293 Integrase core domain; Region: rve; pfam00665 710421000294 Predicted ATPase [General function prediction only]; Region: COG4637 710421000295 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 710421000296 putative active site [active] 710421000297 putative metal-binding site [ion binding]; other site 710421000298 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710421000299 Part of AAA domain; Region: AAA_19; pfam13245 710421000300 TrwC relaxase; Region: TrwC; pfam08751 710421000301 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 710421000302 AAA domain; Region: AAA_30; pfam13604 710421000303 Family description; Region: UvrD_C_2; pfam13538 710421000304 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710421000305 Walker A motif; other site 710421000306 ATP binding site [chemical binding]; other site 710421000307 Walker B motif; other site 710421000308 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 710421000309 Short C-terminal domain; Region: SHOCT; pfam09851 710421000310 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 710421000311 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710421000312 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710421000313 ligand binding site [chemical binding]; other site 710421000314 flexible hinge region; other site 710421000315 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710421000316 putative switch regulator; other site 710421000317 non-specific DNA interactions [nucleotide binding]; other site 710421000318 DNA binding site [nucleotide binding] 710421000319 sequence specific DNA binding site [nucleotide binding]; other site 710421000320 putative cAMP binding site [chemical binding]; other site 710421000321 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710421000322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421000323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421000324 active site 710421000325 ATP binding site [chemical binding]; other site 710421000326 substrate binding site [chemical binding]; other site 710421000327 activation loop (A-loop); other site 710421000328 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710421000329 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 710421000330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421000331 Walker A motif; other site 710421000332 ATP binding site [chemical binding]; other site 710421000333 Walker B motif; other site 710421000334 arginine finger; other site 710421000335 AAA-like domain; Region: AAA_10; pfam12846 710421000336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421000337 salt bridge; other site 710421000338 non-specific DNA binding site [nucleotide binding]; other site 710421000339 sequence-specific DNA binding site [nucleotide binding]; other site 710421000340 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710421000341 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710421000342 catalytic residues [active] 710421000343 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 710421000344 active site 710421000345 catalytic residues [active] 710421000346 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 710421000347 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 710421000348 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710421000349 EspG family; Region: ESX-1_EspG; pfam14011 710421000350 PPE family; Region: PPE; pfam00823 710421000351 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710421000352 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 710421000353 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421000354 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710421000355 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421000356 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421000357 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710421000358 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 710421000359 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710421000360 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 710421000361 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710421000362 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421000363 P-loop; other site 710421000364 Magnesium ion binding site [ion binding]; other site 710421000365 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421000366 Magnesium ion binding site [ion binding]; other site 710421000367 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710421000368 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421000369 P-loop; other site 710421000370 Magnesium ion binding site [ion binding]; other site 710421000371 ParB-like nuclease domain; Region: ParB; smart00470 710421000372 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 710421000373 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 710421000374 active site 710421000375 catalytic triad [active] 710421000376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421000377 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710421000378 Walker A motif; other site 710421000379 ATP binding site [chemical binding]; other site 710421000380 Walker B motif; other site 710421000381 arginine finger; other site 710421000382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421000383 salt bridge; other site 710421000384 non-specific DNA binding site [nucleotide binding]; other site 710421000385 sequence-specific DNA binding site [nucleotide binding]; other site 710421000386 Transcription factor WhiB; Region: Whib; pfam02467 710421000387 Methyltransferase domain; Region: Methyltransf_26; pfam13659 710421000388 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 710421000389 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710421000390 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710421000391 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710421000392 helicase superfamily c-terminal domain; Region: HELICc; smart00490 710421000393 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 710421000394 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421000395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421000396 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421000397 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421000398 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421000399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421000400 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421000401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421000402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421000403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000404 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421000405 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710421000406 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421000407 dimer interface [polypeptide binding]; other site 710421000408 active site 710421000409 enoyl-CoA hydratase; Provisional; Region: PRK08138 710421000410 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421000411 substrate binding site [chemical binding]; other site 710421000412 oxyanion hole (OAH) forming residues; other site 710421000413 trimer interface [polypeptide binding]; other site 710421000414 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421000415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421000416 active site 710421000417 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710421000418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421000419 NAD(P) binding site [chemical binding]; other site 710421000420 active site 710421000421 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 710421000422 ThiC-associated domain; Region: ThiC-associated; pfam13667 710421000423 ThiC family; Region: ThiC; pfam01964 710421000424 envelope glycoprotein E; Provisional; Region: PHA03283 710421000425 Lsr2; Region: Lsr2; pfam11774 710421000426 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000427 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710421000428 active site 710421000429 DNA binding site [nucleotide binding] 710421000430 Int/Topo IB signature motif; other site 710421000431 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421000432 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710421000433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710421000434 PAS domain; Region: PAS_9; pfam13426 710421000435 putative active site [active] 710421000436 heme pocket [chemical binding]; other site 710421000437 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421000438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421000439 metal binding site [ion binding]; metal-binding site 710421000440 active site 710421000441 I-site; other site 710421000442 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 710421000443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421000444 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710421000445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421000446 DNA binding residues [nucleotide binding] 710421000447 MarR family; Region: MarR_2; pfam12802 710421000448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421000449 Integrase core domain; Region: rve; pfam00665 710421000450 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710421000451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421000452 Walker A motif; other site 710421000453 ATP binding site [chemical binding]; other site 710421000454 Walker B motif; other site 710421000455 Integrase core domain; Region: rve; pfam00665 710421000456 Transposase; Region: HTH_Tnp_1; cl17663 710421000457 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421000458 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421000459 Conserved TM helix; Region: TM_helix; pfam05552 710421000460 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 710421000461 Winged helix-turn helix; Region: HTH_29; pfam13551 710421000462 Integrase core domain; Region: rve; pfam00665 710421000463 Integrase core domain; Region: rve_3; pfam13683 710421000464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421000465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000466 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421000467 CoenzymeA binding site [chemical binding]; other site 710421000468 subunit interaction site [polypeptide binding]; other site 710421000469 PHB binding site; other site 710421000470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421000471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000472 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421000473 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 710421000474 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000475 active site 710421000476 Int/Topo IB signature motif; other site 710421000477 DNA binding site [nucleotide binding] 710421000478 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710421000479 DNA binding site [nucleotide binding] 710421000480 active site 710421000481 Int/Topo IB signature motif; other site 710421000482 catalytic residues [active] 710421000483 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710421000484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000486 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000487 alkylmercury lyase; Provisional; Region: PRK13239 710421000488 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 710421000489 Alkylmercury lyase; Region: MerB; pfam03243 710421000490 mercuric reductase; Region: MerA; TIGR02053 710421000491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000492 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421000494 dimerization interface [polypeptide binding]; other site 710421000495 putative DNA binding site [nucleotide binding]; other site 710421000496 putative Zn2+ binding site [ion binding]; other site 710421000497 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421000498 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710421000499 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 710421000500 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 710421000501 DNA binding residues [nucleotide binding] 710421000502 dimer interface [polypeptide binding]; other site 710421000503 H+ Antiporter protein; Region: 2A0121; TIGR00900 710421000504 Transmembrane secretion effector; Region: MFS_3; pfam05977 710421000505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421000506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421000507 non-specific DNA binding site [nucleotide binding]; other site 710421000508 salt bridge; other site 710421000509 sequence-specific DNA binding site [nucleotide binding]; other site 710421000510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710421000511 Rhodanese-like domain; Region: Rhodanese; pfam00581 710421000512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421000513 active site residue [active] 710421000514 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710421000515 Domain of unknown function DUF302; Region: DUF302; pfam03625 710421000516 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710421000517 putative homotetramer interface [polypeptide binding]; other site 710421000518 putative homodimer interface [polypeptide binding]; other site 710421000519 putative allosteric switch controlling residues; other site 710421000520 putative metal binding site [ion binding]; other site 710421000521 putative homodimer-homodimer interface [polypeptide binding]; other site 710421000522 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 710421000523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421000525 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421000526 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421000527 active site residue [active] 710421000528 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421000529 active site residue [active] 710421000530 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 710421000531 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710421000532 putative homodimer interface [polypeptide binding]; other site 710421000533 putative homotetramer interface [polypeptide binding]; other site 710421000534 putative allosteric switch controlling residues; other site 710421000535 putative metal binding site [ion binding]; other site 710421000536 putative homodimer-homodimer interface [polypeptide binding]; other site 710421000537 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710421000538 active site 710421000539 catalytic residues [active] 710421000540 DNA binding site [nucleotide binding] 710421000541 Int/Topo IB signature motif; other site 710421000542 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710421000543 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000544 active site 710421000545 DNA binding site [nucleotide binding] 710421000546 Int/Topo IB signature motif; other site 710421000547 Abi-like protein; Region: Abi_2; pfam07751 710421000548 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 710421000549 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421000550 dimerization interface [polypeptide binding]; other site 710421000551 putative DNA binding site [nucleotide binding]; other site 710421000552 putative Zn2+ binding site [ion binding]; other site 710421000553 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 710421000554 arsenical-resistance protein; Region: acr3; TIGR00832 710421000555 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710421000556 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710421000557 active site 710421000558 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710421000559 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710421000560 active site 710421000561 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 710421000562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421000565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421000566 putative substrate translocation pore; other site 710421000567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421000569 dimerization interface [polypeptide binding]; other site 710421000570 putative DNA binding site [nucleotide binding]; other site 710421000571 putative Zn2+ binding site [ion binding]; other site 710421000572 Helix-turn-helix domain; Region: HTH_18; pfam12833 710421000573 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 710421000574 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 710421000575 AMP-binding enzyme; Region: AMP-binding; pfam00501 710421000576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421000577 active site 710421000578 CoA binding site [chemical binding]; other site 710421000579 AMP binding site [chemical binding]; other site 710421000580 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421000581 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710421000582 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710421000583 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 710421000584 Walker A/P-loop; other site 710421000585 ATP binding site [chemical binding]; other site 710421000586 Q-loop/lid; other site 710421000587 ABC transporter signature motif; other site 710421000588 Walker B; other site 710421000589 D-loop; other site 710421000590 H-loop/switch region; other site 710421000591 TOBE domain; Region: TOBE_2; pfam08402 710421000592 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 710421000593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421000594 dimer interface [polypeptide binding]; other site 710421000595 conserved gate region; other site 710421000596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 710421000597 ABC-ATPase subunit interface; other site 710421000598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421000599 dimer interface [polypeptide binding]; other site 710421000600 conserved gate region; other site 710421000601 ABC-ATPase subunit interface; other site 710421000602 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 710421000603 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710421000604 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421000605 dimerization interface [polypeptide binding]; other site 710421000606 putative DNA binding site [nucleotide binding]; other site 710421000607 putative Zn2+ binding site [ion binding]; other site 710421000608 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 710421000609 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421000610 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421000611 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 710421000612 Cadmium resistance transporter; Region: Cad; pfam03596 710421000613 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710421000614 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421000615 catalytic residues [active] 710421000616 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710421000617 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710421000618 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710421000619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421000620 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421000621 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710421000622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421000623 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710421000624 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421000625 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421000626 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421000627 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710421000628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421000629 dimer interface [polypeptide binding]; other site 710421000630 phosphorylation site [posttranslational modification] 710421000631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421000632 ATP binding site [chemical binding]; other site 710421000633 Mg2+ binding site [ion binding]; other site 710421000634 G-X-G motif; other site 710421000635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421000636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421000637 active site 710421000638 phosphorylation site [posttranslational modification] 710421000639 intermolecular recognition site; other site 710421000640 dimerization interface [polypeptide binding]; other site 710421000641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421000642 DNA binding site [nucleotide binding] 710421000643 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710421000644 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710421000645 Multicopper oxidase; Region: Cu-oxidase; pfam00394 710421000646 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710421000647 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710421000648 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710421000649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421000650 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421000651 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710421000652 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421000653 catalytic residues [active] 710421000654 Penicillinase repressor; Region: Pencillinase_R; cl17580 710421000655 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710421000656 Peptidase family M48; Region: Peptidase_M48; cl12018 710421000657 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 710421000658 Putative esterase; Region: Esterase; pfam00756 710421000659 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 710421000660 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 710421000661 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710421000662 Peptidase family M23; Region: Peptidase_M23; pfam01551 710421000663 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 710421000664 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 710421000665 putative active site [active] 710421000666 catalytic triad [active] 710421000667 putative dimer interface [polypeptide binding]; other site 710421000668 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710421000669 multidrug resistance protein MdtH; Provisional; Region: PRK11646 710421000670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421000671 putative substrate translocation pore; other site 710421000672 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710421000673 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710421000674 dimer interface [polypeptide binding]; other site 710421000675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421000676 catalytic residue [active] 710421000677 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710421000678 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710421000679 NodB motif; other site 710421000680 active site 710421000681 catalytic site [active] 710421000682 metal binding site [ion binding]; metal-binding site 710421000683 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421000684 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421000685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 710421000686 active site 710421000687 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421000688 phosphorylation site [posttranslational modification] 710421000689 intermolecular recognition site; other site 710421000690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421000691 DNA binding site [nucleotide binding] 710421000692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421000693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000694 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710421000695 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710421000696 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710421000697 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710421000698 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421000699 catalytic residues [active] 710421000700 pyrimidine utilization protein D; Region: RutD; TIGR03611 710421000701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710421000702 metal-binding site [ion binding] 710421000703 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710421000704 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710421000705 metal-binding site [ion binding] 710421000706 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421000707 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421000708 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 710421000709 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710421000710 putative homotetramer interface [polypeptide binding]; other site 710421000711 putative homodimer interface [polypeptide binding]; other site 710421000712 putative allosteric switch controlling residues; other site 710421000713 putative metal binding site [ion binding]; other site 710421000714 putative homodimer-homodimer interface [polypeptide binding]; other site 710421000715 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 710421000716 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421000717 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421000718 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 710421000719 RES domain; Region: RES; cl02411 710421000720 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 710421000721 putative active site [active] 710421000722 transposase; Provisional; Region: PRK06526 710421000723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421000724 Walker A motif; other site 710421000725 ATP binding site [chemical binding]; other site 710421000726 Walker B motif; other site 710421000727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421000728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421000729 non-specific DNA binding site [nucleotide binding]; other site 710421000730 salt bridge; other site 710421000731 sequence-specific DNA binding site [nucleotide binding]; other site 710421000732 Integrase core domain; Region: rve; pfam00665 710421000733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421000734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421000735 putative substrate translocation pore; other site 710421000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421000737 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421000738 CoenzymeA binding site [chemical binding]; other site 710421000739 subunit interaction site [polypeptide binding]; other site 710421000740 PHB binding site; other site 710421000741 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 710421000742 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 710421000743 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710421000744 HTH-like domain; Region: HTH_21; pfam13276 710421000745 Integrase core domain; Region: rve; pfam00665 710421000746 Integrase core domain; Region: rve_3; cl15866 710421000747 RDD family; Region: RDD; pfam06271 710421000748 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421000749 mce related protein; Region: MCE; pfam02470 710421000750 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421000751 mce related protein; Region: MCE; pfam02470 710421000752 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421000753 mce related protein; Region: MCE; pfam02470 710421000754 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421000755 mce related protein; Region: MCE; pfam02470 710421000756 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421000757 mce related protein; Region: MCE; pfam02470 710421000758 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421000759 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421000760 mce related protein; Region: MCE; pfam02470 710421000761 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421000762 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421000763 Permease; Region: Permease; pfam02405 710421000764 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421000765 Permease; Region: Permease; pfam02405 710421000766 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710421000767 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710421000768 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421000769 envelope glycoprotein E; Provisional; Region: PHA03283 710421000770 Lsr2; Region: Lsr2; pfam11774 710421000771 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710421000772 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710421000773 NAD binding site [chemical binding]; other site 710421000774 catalytic Zn binding site [ion binding]; other site 710421000775 substrate binding site [chemical binding]; other site 710421000776 structural Zn binding site [ion binding]; other site 710421000777 SCP-2 sterol transfer family; Region: SCP2; pfam02036 710421000778 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 710421000779 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 710421000780 putative active site [active] 710421000781 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421000782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421000783 active site 710421000784 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710421000785 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710421000786 dimer interface [polypeptide binding]; other site 710421000787 acyl-activating enzyme (AAE) consensus motif; other site 710421000788 putative active site [active] 710421000789 AMP binding site [chemical binding]; other site 710421000790 putative CoA binding site [chemical binding]; other site 710421000791 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710421000792 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710421000793 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 710421000794 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 710421000795 Cytochrome P450; Region: p450; cl12078 710421000796 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421000797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421000798 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421000799 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421000800 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421000801 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421000802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421000803 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421000804 classical (c) SDRs; Region: SDR_c; cd05233 710421000805 NAD(P) binding site [chemical binding]; other site 710421000806 active site 710421000807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421000808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000809 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 710421000810 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 710421000811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421000812 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 710421000813 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421000814 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710421000815 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421000816 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421000817 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 710421000818 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710421000819 carboxyltransferase (CT) interaction site; other site 710421000820 biotinylation site [posttranslational modification]; other site 710421000821 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421000822 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421000823 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421000824 active site 710421000825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710421000826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421000827 acyl-activating enzyme (AAE) consensus motif; other site 710421000828 AMP binding site [chemical binding]; other site 710421000829 active site 710421000830 CoA binding site [chemical binding]; other site 710421000831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000832 Winged helix-turn helix; Region: HTH_29; pfam13551 710421000833 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710421000834 DNA-binding interface [nucleotide binding]; DNA binding site 710421000835 Integrase core domain; Region: rve; pfam00665 710421000836 Integrase core domain; Region: rve_3; pfam13683 710421000837 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 710421000838 TIGR03084 family protein; Region: TIGR03084 710421000839 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421000840 Wyosine base formation; Region: Wyosine_form; pfam08608 710421000841 enoyl-CoA hydratase; Provisional; Region: PRK06494 710421000842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421000843 substrate binding site [chemical binding]; other site 710421000844 oxyanion hole (OAH) forming residues; other site 710421000845 trimer interface [polypeptide binding]; other site 710421000846 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421000847 active site 2 [active] 710421000848 active site 1 [active] 710421000849 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 710421000850 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421000851 active site 2 [active] 710421000852 active site 1 [active] 710421000853 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 710421000854 active site 2 [active] 710421000855 active site 1 [active] 710421000856 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 710421000857 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421000858 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710421000859 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710421000860 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421000861 thiolase; Provisional; Region: PRK06158 710421000862 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421000863 active site 710421000864 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 710421000865 Uncharacterized ACR, COG1753; Region: DUF217; cl00762 710421000866 Helix-turn-helix domain; Region: HTH_18; pfam12833 710421000867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421000868 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710421000869 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421000870 catalytic loop [active] 710421000871 iron binding site [ion binding]; other site 710421000872 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421000873 Cytochrome P450; Region: p450; cl12078 710421000874 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 710421000875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421000878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421000879 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421000880 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421000881 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421000882 CoenzymeA binding site [chemical binding]; other site 710421000883 subunit interaction site [polypeptide binding]; other site 710421000884 PHB binding site; other site 710421000885 ERCC4 domain; Region: ERCC4; smart00891 710421000886 Lsr2; Region: Lsr2; pfam11774 710421000887 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421000888 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421000889 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421000890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421000891 non-specific DNA binding site [nucleotide binding]; other site 710421000892 salt bridge; other site 710421000893 sequence-specific DNA binding site [nucleotide binding]; other site 710421000894 H+ Antiporter protein; Region: 2A0121; TIGR00900 710421000895 Transmembrane secretion effector; Region: MFS_3; pfam05977 710421000896 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 710421000897 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 710421000898 DNA binding residues [nucleotide binding] 710421000899 dimer interface [polypeptide binding]; other site 710421000900 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421000901 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710421000902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421000903 dimerization interface [polypeptide binding]; other site 710421000904 putative DNA binding site [nucleotide binding]; other site 710421000905 putative Zn2+ binding site [ion binding]; other site 710421000906 mercuric reductase; Region: MerA; TIGR02053 710421000907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000908 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000909 alkylmercury lyase; Provisional; Region: PRK13239 710421000910 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 710421000911 Alkylmercury lyase; Region: MerB; pfam03243 710421000912 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710421000913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421000914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421000915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421000916 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000917 active site 710421000918 Int/Topo IB signature motif; other site 710421000919 DNA binding site [nucleotide binding] 710421000920 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710421000921 DNA binding site [nucleotide binding] 710421000922 active site 710421000923 Int/Topo IB signature motif; other site 710421000924 catalytic residues [active] 710421000925 ParB-like nuclease domain; Region: ParB; smart00470 710421000926 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710421000927 catalytic residues [active] 710421000928 TrwC relaxase; Region: TrwC; pfam08751 710421000929 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 710421000930 AAA domain; Region: AAA_30; pfam13604 710421000931 Family description; Region: UvrD_C_2; pfam13538 710421000932 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710421000933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421000934 catalytic loop [active] 710421000935 iron binding site [ion binding]; other site 710421000936 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710421000937 FAD binding pocket [chemical binding]; other site 710421000938 conserved FAD binding motif [chemical binding]; other site 710421000939 phosphate binding motif [ion binding]; other site 710421000940 beta-alpha-beta structure motif; other site 710421000941 NAD binding pocket [chemical binding]; other site 710421000942 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710421000943 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 710421000944 dimerization interface [polypeptide binding]; other site 710421000945 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 710421000946 dimerization interface [polypeptide binding]; other site 710421000947 putative path to active site cavity [active] 710421000948 diiron center [ion binding]; other site 710421000949 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421000950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421000951 DNA binding residues [nucleotide binding] 710421000952 dimerization interface [polypeptide binding]; other site 710421000953 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710421000954 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 710421000955 ATP binding site [chemical binding]; other site 710421000956 Mg2+ binding site [ion binding]; other site 710421000957 G-X-G motif; other site 710421000958 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710421000959 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 710421000960 active site 710421000961 NAD binding site [chemical binding]; other site 710421000962 metal binding site [ion binding]; metal-binding site 710421000963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421000964 Histidine kinase; Region: HisKA_3; pfam07730 710421000965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421000966 ATP binding site [chemical binding]; other site 710421000967 Mg2+ binding site [ion binding]; other site 710421000968 G-X-G motif; other site 710421000969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421000970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421000971 active site 710421000972 phosphorylation site [posttranslational modification] 710421000973 intermolecular recognition site; other site 710421000974 dimerization interface [polypeptide binding]; other site 710421000975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421000976 DNA binding residues [nucleotide binding] 710421000977 dimerization interface [polypeptide binding]; other site 710421000978 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710421000979 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 710421000980 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 710421000981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421000982 FeS/SAM binding site; other site 710421000983 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 710421000984 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 710421000985 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710421000986 phosphate binding site [ion binding]; other site 710421000987 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710421000988 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000989 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000990 active site 710421000991 DNA binding site [nucleotide binding] 710421000992 Int/Topo IB signature motif; other site 710421000993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421000994 active site 710421000995 DNA binding site [nucleotide binding] 710421000996 Int/Topo IB signature motif; other site 710421000997 Peptidase family M48; Region: Peptidase_M48; cl12018 710421000998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421000999 Integrase core domain; Region: rve; pfam00665 710421001000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421001001 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 710421001002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421001003 Predicted integral membrane protein [Function unknown]; Region: COG5660 710421001004 Putative zinc-finger; Region: zf-HC2; pfam13490 710421001005 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 710421001006 Methane monooxygenase, hydrolase gamma chain; Region: MeMO_Hyd_G; pfam02964 710421001007 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 710421001008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421001009 catalytic loop [active] 710421001010 iron binding site [ion binding]; other site 710421001011 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710421001012 FAD binding pocket [chemical binding]; other site 710421001013 conserved FAD binding motif [chemical binding]; other site 710421001014 phosphate binding motif [ion binding]; other site 710421001015 beta-alpha-beta structure motif; other site 710421001016 NAD binding pocket [chemical binding]; other site 710421001017 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710421001018 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710421001019 dinuclear metal binding motif [ion binding]; other site 710421001020 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710421001021 dinuclear metal binding motif [ion binding]; other site 710421001022 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 710421001023 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421001024 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421001025 DNA binding residues [nucleotide binding] 710421001026 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 710421001027 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421001028 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710421001029 acyl-activating enzyme (AAE) consensus motif; other site 710421001030 AMP binding site [chemical binding]; other site 710421001031 active site 710421001032 CoA binding site [chemical binding]; other site 710421001033 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 710421001034 Ammonia monooxygenase; Region: AMO; pfam02461 710421001035 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829 710421001036 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 710421001037 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 710421001038 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 710421001039 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710421001040 active site 710421001041 NAD binding site [chemical binding]; other site 710421001042 metal binding site [ion binding]; metal-binding site 710421001043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710421001044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421001045 Walker A motif; other site 710421001046 ATP binding site [chemical binding]; other site 710421001047 Walker B motif; other site 710421001048 arginine finger; other site 710421001049 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 710421001050 RDD family; Region: RDD; pfam06271 710421001051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710421001052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421001053 NAD(P) binding site [chemical binding]; other site 710421001054 active site 710421001055 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421001056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421001057 substrate binding site [chemical binding]; other site 710421001058 oxyanion hole (OAH) forming residues; other site 710421001059 trimer interface [polypeptide binding]; other site 710421001060 putative acyltransferase; Provisional; Region: PRK05790 710421001061 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421001062 dimer interface [polypeptide binding]; other site 710421001063 active site 710421001064 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421001065 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 710421001066 FAD binding site [chemical binding]; other site 710421001067 homotetramer interface [polypeptide binding]; other site 710421001068 substrate binding pocket [chemical binding]; other site 710421001069 catalytic base [active] 710421001070 AMP-binding domain protein; Validated; Region: PRK08315 710421001071 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421001072 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710421001073 acyl-activating enzyme (AAE) consensus motif; other site 710421001074 putative AMP binding site [chemical binding]; other site 710421001075 putative active site [active] 710421001076 putative CoA binding site [chemical binding]; other site 710421001077 Protein of unknown function (DUF779); Region: DUF779; pfam05610 710421001078 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 710421001079 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421001080 NAD(P) binding site [chemical binding]; other site 710421001081 catalytic residues [active] 710421001082 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 710421001083 apolar tunnel; other site 710421001084 heme binding site [chemical binding]; other site 710421001085 dimerization interface [polypeptide binding]; other site 710421001086 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 710421001087 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 710421001088 acyl-activating enzyme (AAE) consensus motif; other site 710421001089 putative AMP binding site [chemical binding]; other site 710421001090 putative active site [active] 710421001091 putative CoA binding site [chemical binding]; other site 710421001092 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421001093 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710421001094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421001095 active site 710421001096 metal binding site [ion binding]; metal-binding site 710421001097 RDD family; Region: RDD; pfam06271 710421001098 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001099 mce related protein; Region: MCE; pfam02470 710421001100 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001101 mce related protein; Region: MCE; pfam02470 710421001102 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001103 mce related protein; Region: MCE; pfam02470 710421001104 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001105 mce related protein; Region: MCE; pfam02470 710421001106 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710421001107 mce related protein; Region: MCE; pfam02470 710421001108 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421001109 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001110 mce related protein; Region: MCE; pfam02470 710421001111 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421001112 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421001113 Permease; Region: Permease; pfam02405 710421001114 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421001115 Permease; Region: Permease; pfam02405 710421001116 Protein of unknown function (DUF779); Region: DUF779; cl01432 710421001117 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 710421001118 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421001119 NAD(P) binding site [chemical binding]; other site 710421001120 catalytic residues [active] 710421001121 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 710421001122 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421001123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421001124 non-specific DNA binding site [nucleotide binding]; other site 710421001125 salt bridge; other site 710421001126 sequence-specific DNA binding site [nucleotide binding]; other site 710421001127 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421001128 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 710421001129 active site 710421001130 DNA binding site [nucleotide binding] 710421001131 Int/Topo IB signature motif; other site 710421001132 putative transposase OrfB; Reviewed; Region: PHA02517 710421001133 HTH-like domain; Region: HTH_21; pfam13276 710421001134 Integrase core domain; Region: rve; pfam00665 710421001135 Integrase core domain; Region: rve_3; cl15866 710421001136 Transposase; Region: HTH_Tnp_1; cl17663 710421001137 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 710421001138 putative catalytic cysteine [active] 710421001139 Secretory lipase; Region: LIP; pfam03583 710421001140 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 710421001141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421001142 dimer interface [polypeptide binding]; other site 710421001143 conserved gate region; other site 710421001144 putative PBP binding loops; other site 710421001145 ABC-ATPase subunit interface; other site 710421001146 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 710421001147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421001148 Walker A/P-loop; other site 710421001149 ATP binding site [chemical binding]; other site 710421001150 Q-loop/lid; other site 710421001151 ABC transporter signature motif; other site 710421001152 Walker B; other site 710421001153 D-loop; other site 710421001154 H-loop/switch region; other site 710421001155 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 710421001156 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421001157 substrate binding pocket [chemical binding]; other site 710421001158 membrane-bound complex binding site; other site 710421001159 hinge residues; other site 710421001160 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421001161 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 710421001162 molybdopterin cofactor binding site; other site 710421001163 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 710421001164 molybdopterin cofactor binding site; other site 710421001165 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710421001166 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 710421001167 tetramer interface [polypeptide binding]; other site 710421001168 D-cysteine desulfhydrase; Validated; Region: PRK03910 710421001169 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710421001170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421001171 catalytic residue [active] 710421001172 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 710421001173 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 710421001174 tetramer interface [polypeptide binding]; other site 710421001175 active site 710421001176 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 710421001177 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 710421001178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421001179 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421001180 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710421001181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421001182 NAD(P) binding site [chemical binding]; other site 710421001183 active site 710421001184 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421001185 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421001186 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 710421001187 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421001188 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710421001189 Coenzyme A transferase; Region: CoA_trans; cl17247 710421001190 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 710421001191 CoA binding domain; Region: CoA_binding; smart00881 710421001192 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 710421001193 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 710421001194 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 710421001195 substrate binding site [chemical binding]; other site 710421001196 THF binding site; other site 710421001197 zinc-binding site [ion binding]; other site 710421001198 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 710421001199 dimerization interface [polypeptide binding]; other site 710421001200 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 710421001201 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 710421001202 dimerization interface [polypeptide binding]; other site 710421001203 putative path to active site cavity [active] 710421001204 diiron center [ion binding]; other site 710421001205 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421001206 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 710421001207 catalytic loop [active] 710421001208 iron binding site [ion binding]; other site 710421001209 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710421001210 FAD binding pocket [chemical binding]; other site 710421001211 conserved FAD binding motif [chemical binding]; other site 710421001212 phosphate binding motif [ion binding]; other site 710421001213 beta-alpha-beta structure motif; other site 710421001214 NAD binding pocket [chemical binding]; other site 710421001215 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 710421001216 pyruvate carboxylase; Reviewed; Region: PRK12999 710421001217 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421001218 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421001219 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710421001220 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 710421001221 active site 710421001222 catalytic residues [active] 710421001223 metal binding site [ion binding]; metal-binding site 710421001224 homodimer binding site [polypeptide binding]; other site 710421001225 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710421001226 carboxyltransferase (CT) interaction site; other site 710421001227 biotinylation site [posttranslational modification]; other site 710421001228 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710421001229 MULE transposase domain; Region: MULE; pfam10551 710421001230 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 710421001231 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421001232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421001233 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421001234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710421001235 classical (c) SDRs; Region: SDR_c; cd05233 710421001236 NAD(P) binding site [chemical binding]; other site 710421001237 active site 710421001238 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 710421001239 Domain of unknown function (DUF955); Region: DUF955; cl01076 710421001240 Domain of unknown function (DUF955); Region: DUF955; pfam06114 710421001241 Helix-turn-helix domain; Region: HTH_19; pfam12844 710421001242 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 710421001243 RES domain; Region: RES; pfam08808 710421001244 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421001245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421001246 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421001247 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710421001248 DNA-binding interface [nucleotide binding]; DNA binding site 710421001249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421001250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421001251 non-specific DNA binding site [nucleotide binding]; other site 710421001252 salt bridge; other site 710421001253 sequence-specific DNA binding site [nucleotide binding]; other site 710421001254 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 710421001255 ParB-like nuclease domain; Region: ParBc; pfam02195 710421001256 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 710421001257 TrwC relaxase; Region: TrwC; pfam08751 710421001258 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 710421001259 AAA domain; Region: AAA_30; pfam13604 710421001260 Family description; Region: UvrD_C_2; pfam13538 710421001261 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710421001262 MULE transposase domain; Region: MULE; pfam10551 710421001263 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421001264 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421001265 active site 710421001266 ATP binding site [chemical binding]; other site 710421001267 substrate binding site [chemical binding]; other site 710421001268 activation loop (A-loop); other site 710421001269 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421001270 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421001271 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 710421001272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421001273 Walker A motif; other site 710421001274 ATP binding site [chemical binding]; other site 710421001275 Walker B motif; other site 710421001276 arginine finger; other site 710421001277 AAA-like domain; Region: AAA_10; pfam12846 710421001278 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 710421001279 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 710421001280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421001281 salt bridge; other site 710421001282 non-specific DNA binding site [nucleotide binding]; other site 710421001283 sequence-specific DNA binding site [nucleotide binding]; other site 710421001284 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 710421001285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421001287 non-specific DNA binding site [nucleotide binding]; other site 710421001288 salt bridge; other site 710421001289 sequence-specific DNA binding site [nucleotide binding]; other site 710421001290 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710421001291 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710421001292 catalytic residues [active] 710421001293 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 710421001294 active site 710421001295 catalytic residues [active] 710421001296 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 710421001297 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 710421001298 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710421001299 EspG family; Region: ESX-1_EspG; pfam14011 710421001300 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 710421001301 PPE family; Region: PPE; pfam00823 710421001302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 710421001303 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710421001304 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 710421001305 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421001306 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710421001307 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421001308 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421001309 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710421001310 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710421001311 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 710421001312 Helix-turn-helix domain; Region: HTH_36; pfam13730 710421001313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421001314 putative DNA binding site [nucleotide binding]; other site 710421001315 dimerization interface [polypeptide binding]; other site 710421001316 putative Zn2+ binding site [ion binding]; other site 710421001317 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 710421001318 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710421001319 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421001320 P-loop; other site 710421001321 Magnesium ion binding site [ion binding]; other site 710421001322 ParB-like nuclease domain; Region: ParB; smart00470 710421001323 transposase/IS protein; Provisional; Region: PRK09183 710421001324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421001325 Walker A motif; other site 710421001326 ATP binding site [chemical binding]; other site 710421001327 Walker B motif; other site 710421001328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421001329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421001330 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421001331 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421001332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421001333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421001334 V-type ATP synthase subunit I; Validated; Region: PRK05771 710421001335 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 710421001336 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421001337 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421001338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421001339 salt bridge; other site 710421001340 non-specific DNA binding site [nucleotide binding]; other site 710421001341 sequence-specific DNA binding site [nucleotide binding]; other site 710421001342 Transcription factor WhiB; Region: Whib; pfam02467 710421001343 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 710421001344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421001345 S-adenosylmethionine binding site [chemical binding]; other site 710421001346 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 710421001347 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710421001348 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710421001349 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 710421001350 helicase superfamily c-terminal domain; Region: HELICc; smart00490 710421001351 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 710421001352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421001353 Walker A motif; other site 710421001354 ATP binding site [chemical binding]; other site 710421001355 Walker B motif; other site 710421001356 arginine finger; other site 710421001357 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 710421001358 DnaA box-binding interface [nucleotide binding]; other site 710421001359 DNA polymerase III subunit beta; Validated; Region: PRK07761 710421001360 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 710421001361 putative DNA binding surface [nucleotide binding]; other site 710421001362 dimer interface [polypeptide binding]; other site 710421001363 beta-clamp/clamp loader binding surface; other site 710421001364 beta-clamp/translesion DNA polymerase binding surface; other site 710421001365 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421001366 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 710421001367 recombination protein F; Reviewed; Region: recF; PRK00064 710421001368 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 710421001369 Walker A/P-loop; other site 710421001370 ATP binding site [chemical binding]; other site 710421001371 Q-loop/lid; other site 710421001372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421001373 ABC transporter signature motif; other site 710421001374 Walker B; other site 710421001375 D-loop; other site 710421001376 H-loop/switch region; other site 710421001377 hypothetical protein; Provisional; Region: PRK03195 710421001378 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 710421001379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421001380 Mg2+ binding site [ion binding]; other site 710421001381 G-X-G motif; other site 710421001382 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 710421001383 anchoring element; other site 710421001384 dimer interface [polypeptide binding]; other site 710421001385 ATP binding site [chemical binding]; other site 710421001386 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710421001387 active site 710421001388 putative metal-binding site [ion binding]; other site 710421001389 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710421001390 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 710421001391 CAP-like domain; other site 710421001392 active site 710421001393 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 710421001394 protein-splicing catalytic site; other site 710421001395 thioester formation/cholesterol transfer; other site 710421001396 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 710421001397 DNA gyrase subunit A; Validated; Region: PRK05560 710421001398 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 710421001399 primary dimer interface [polypeptide binding]; other site 710421001400 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710421001401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710421001402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710421001403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710421001404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710421001405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710421001406 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 710421001407 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 710421001408 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 710421001409 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 710421001410 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 710421001411 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710421001412 active site 710421001413 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710421001414 putative septation inhibitor protein; Reviewed; Region: PRK00159 710421001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710421001416 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710421001417 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 710421001418 Glutamine amidotransferase class-I; Region: GATase; pfam00117 710421001419 glutamine binding [chemical binding]; other site 710421001420 catalytic triad [active] 710421001421 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710421001422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421001423 active site 710421001424 ATP binding site [chemical binding]; other site 710421001425 substrate binding site [chemical binding]; other site 710421001426 activation loop (A-loop); other site 710421001427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 710421001428 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710421001429 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710421001430 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710421001431 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710421001432 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421001433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421001434 active site 710421001435 ATP binding site [chemical binding]; other site 710421001436 substrate binding site [chemical binding]; other site 710421001437 activation loop (A-loop); other site 710421001438 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710421001439 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710421001440 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 710421001441 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710421001442 active site 710421001443 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710421001444 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421001445 phosphopeptide binding site; other site 710421001446 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 710421001447 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421001448 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710421001449 phosphopeptide binding site; other site 710421001450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421001451 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710421001452 NAD(P) binding site [chemical binding]; other site 710421001453 active site 710421001454 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 710421001455 Protein of unknown function (DUF998); Region: DUF998; pfam06197 710421001456 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 710421001457 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 710421001458 putative heme binding pocket [chemical binding]; other site 710421001459 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 710421001460 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421001461 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421001462 catalytic residue [active] 710421001463 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 710421001464 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421001465 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 710421001466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421001467 inhibitor-cofactor binding pocket; inhibition site 710421001468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421001469 catalytic residue [active] 710421001470 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710421001471 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710421001472 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710421001473 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 710421001474 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 710421001475 putative active site [active] 710421001476 putative dimer interface [polypeptide binding]; other site 710421001477 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 710421001478 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 710421001479 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 710421001480 putative active site [active] 710421001481 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421001482 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421001483 metal binding site [ion binding]; metal-binding site 710421001484 active site 710421001485 I-site; other site 710421001486 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 710421001487 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 710421001488 ChaB; Region: ChaB; pfam06150 710421001489 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 710421001490 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421001491 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 710421001492 NAD(P) binding site [chemical binding]; other site 710421001493 catalytic residues [active] 710421001494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421001495 dimer interface [polypeptide binding]; other site 710421001496 conserved gate region; other site 710421001497 ABC-ATPase subunit interface; other site 710421001498 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 710421001499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421001500 dimer interface [polypeptide binding]; other site 710421001501 conserved gate region; other site 710421001502 putative PBP binding loops; other site 710421001503 ABC-ATPase subunit interface; other site 710421001504 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710421001505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421001506 Walker A/P-loop; other site 710421001507 ATP binding site [chemical binding]; other site 710421001508 Q-loop/lid; other site 710421001509 ABC transporter signature motif; other site 710421001510 Walker B; other site 710421001511 D-loop; other site 710421001512 H-loop/switch region; other site 710421001513 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710421001514 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710421001515 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 710421001516 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 710421001517 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 710421001518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421001519 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 710421001520 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710421001521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421001522 DNA-binding site [nucleotide binding]; DNA binding site 710421001523 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710421001524 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710421001525 Cupin superfamily protein; Region: Cupin_4; pfam08007 710421001526 Cupin-like domain; Region: Cupin_8; pfam13621 710421001527 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 710421001528 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 710421001529 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421001530 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710421001531 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421001532 active site 2 [active] 710421001533 Predicted acetyltransferase [General function prediction only]; Region: COG2388 710421001534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421001535 Coenzyme A binding pocket [chemical binding]; other site 710421001536 Pirin-related protein [General function prediction only]; Region: COG1741 710421001537 Pirin; Region: Pirin; pfam02678 710421001538 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710421001539 hypothetical protein; Provisional; Region: PRK02268 710421001540 DivIVA domain; Region: DivI1A_domain; TIGR03544 710421001541 DivIVA domain; Region: DivI1A_domain; TIGR03544 710421001542 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710421001543 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421001544 Transcription factor WhiB; Region: Whib; pfam02467 710421001545 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710421001546 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 710421001547 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 710421001548 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421001549 P-loop; other site 710421001550 Magnesium ion binding site [ion binding]; other site 710421001551 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 710421001552 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421001553 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 710421001554 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 710421001555 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710421001556 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 710421001557 active site 710421001558 catalytic residues [active] 710421001559 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 710421001560 dimerization domain swap beta strand [polypeptide binding]; other site 710421001561 regulatory protein interface [polypeptide binding]; other site 710421001562 active site 710421001563 regulatory phosphorylation site [posttranslational modification]; other site 710421001564 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 710421001565 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 710421001566 active site 710421001567 phosphorylation site [posttranslational modification] 710421001568 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 710421001569 active site 710421001570 P-loop; other site 710421001571 phosphorylation site [posttranslational modification] 710421001572 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 710421001573 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 710421001574 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 710421001575 putative substrate binding site [chemical binding]; other site 710421001576 putative ATP binding site [chemical binding]; other site 710421001577 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 710421001578 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 710421001579 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710421001580 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 710421001581 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 710421001582 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710421001583 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710421001584 Pirin-related protein [General function prediction only]; Region: COG1741 710421001585 Pirin; Region: Pirin; pfam02678 710421001586 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710421001587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421001588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421001589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421001590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421001591 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421001592 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421001593 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 710421001594 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 710421001595 NAD(P) binding site [chemical binding]; other site 710421001596 catalytic residues [active] 710421001597 short chain dehydrogenase; Provisional; Region: PRK07791 710421001598 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 710421001599 NAD binding site [chemical binding]; other site 710421001600 homodimer interface [polypeptide binding]; other site 710421001601 active site 710421001602 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710421001603 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710421001604 NAD(P) binding site [chemical binding]; other site 710421001605 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 710421001606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421001607 motif II; other site 710421001608 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421001609 Protein of unknown function (DUF456); Region: DUF456; pfam04306 710421001610 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 710421001611 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 710421001612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421001613 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421001614 active site 710421001615 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710421001616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421001617 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710421001618 iron-sulfur cluster [ion binding]; other site 710421001619 [2Fe-2S] cluster binding site [ion binding]; other site 710421001620 Helix-turn-helix domain; Region: HTH_18; pfam12833 710421001621 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421001622 GAF domain; Region: GAF; pfam01590 710421001623 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710421001624 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421001625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421001626 active site 710421001627 phosphorylation site [posttranslational modification] 710421001628 intermolecular recognition site; other site 710421001629 dimerization interface [polypeptide binding]; other site 710421001630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421001631 DNA binding residues [nucleotide binding] 710421001632 dimerization interface [polypeptide binding]; other site 710421001633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421001634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421001635 ATP binding site [chemical binding]; other site 710421001636 Mg2+ binding site [ion binding]; other site 710421001637 G-X-G motif; other site 710421001638 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 710421001639 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 710421001640 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 710421001641 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 710421001642 ligand binding site [chemical binding]; other site 710421001643 homodimer interface [polypeptide binding]; other site 710421001644 NAD(P) binding site [chemical binding]; other site 710421001645 trimer interface B [polypeptide binding]; other site 710421001646 trimer interface A [polypeptide binding]; other site 710421001647 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 710421001648 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 710421001649 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 710421001650 catalytic Zn binding site [ion binding]; other site 710421001651 NAD binding site [chemical binding]; other site 710421001652 structural Zn binding site [ion binding]; other site 710421001653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421001654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421001655 Protein of unknown function DUF72; Region: DUF72; pfam01904 710421001656 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710421001657 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710421001658 putative hydrophobic ligand binding site [chemical binding]; other site 710421001659 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710421001660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421001661 DNA-binding site [nucleotide binding]; DNA binding site 710421001662 FCD domain; Region: FCD; pfam07729 710421001663 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 710421001664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421001665 acyl-activating enzyme (AAE) consensus motif; other site 710421001666 AMP binding site [chemical binding]; other site 710421001667 active site 710421001668 CoA binding site [chemical binding]; other site 710421001669 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421001670 Permease; Region: Permease; pfam02405 710421001671 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421001672 Permease; Region: Permease; pfam02405 710421001673 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001674 mce related protein; Region: MCE; pfam02470 710421001675 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421001676 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001677 mce related protein; Region: MCE; pfam02470 710421001678 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421001679 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001680 mce related protein; Region: MCE; pfam02470 710421001681 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 710421001682 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710421001683 mce related protein; Region: MCE; pfam02470 710421001684 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421001685 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001686 mce related protein; Region: MCE; pfam02470 710421001687 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421001688 mce related protein; Region: MCE; pfam02470 710421001689 RDD family; Region: RDD; pfam06271 710421001690 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 710421001691 Fructosamine kinase; Region: Fructosamin_kin; cl17579 710421001692 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 710421001693 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 710421001694 putative hydrophobic ligand binding site [chemical binding]; other site 710421001695 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 710421001696 Pirin-related protein [General function prediction only]; Region: COG1741 710421001697 Pirin; Region: Pirin; pfam02678 710421001698 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 710421001699 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710421001700 MarR family; Region: MarR_2; pfam12802 710421001701 RNA polymerase factor sigma-70; Validated; Region: PRK08241 710421001702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421001703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421001704 DNA binding residues [nucleotide binding] 710421001705 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710421001706 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710421001707 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421001708 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 710421001709 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 710421001710 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710421001711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421001712 S-adenosylmethionine binding site [chemical binding]; other site 710421001713 CsbD-like; Region: CsbD; pfam05532 710421001714 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710421001715 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710421001716 active site 710421001717 iron coordination sites [ion binding]; other site 710421001718 substrate binding pocket [chemical binding]; other site 710421001719 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421001720 hypothetical protein; Provisional; Region: PRK06849 710421001721 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421001722 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710421001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421001724 S-adenosylmethionine binding site [chemical binding]; other site 710421001725 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710421001726 active site 710421001727 NAD binding site [chemical binding]; other site 710421001728 metal binding site [ion binding]; metal-binding site 710421001729 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 710421001730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421001731 motif II; other site 710421001732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421001733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421001734 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710421001735 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 710421001736 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710421001737 putative hydrophobic ligand binding site [chemical binding]; other site 710421001738 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 710421001739 6-phosphogluconate dehydratase; Region: edd; TIGR01196 710421001740 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710421001741 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710421001742 putative homotetramer interface [polypeptide binding]; other site 710421001743 putative homodimer interface [polypeptide binding]; other site 710421001744 putative allosteric switch controlling residues; other site 710421001745 putative metal binding site [ion binding]; other site 710421001746 putative homodimer-homodimer interface [polypeptide binding]; other site 710421001747 PGAP1-like protein; Region: PGAP1; pfam07819 710421001748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421001749 Domain of unknown function DUF77; Region: DUF77; pfam01910 710421001750 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421001751 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710421001752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421001753 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421001754 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 710421001755 MoxR-like ATPases [General function prediction only]; Region: COG0714 710421001756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421001757 ATP binding site [chemical binding]; other site 710421001758 Walker A motif; other site 710421001759 Walker B motif; other site 710421001760 arginine finger; other site 710421001761 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710421001762 Protein of unknown function DUF58; Region: DUF58; pfam01882 710421001763 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710421001764 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710421001765 NodB motif; other site 710421001766 active site 710421001767 catalytic site [active] 710421001768 metal binding site [ion binding]; metal-binding site 710421001769 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 710421001770 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 710421001771 active site 710421001772 Zn binding site [ion binding]; other site 710421001773 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421001774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421001775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421001776 active site 710421001777 phosphorylation site [posttranslational modification] 710421001778 intermolecular recognition site; other site 710421001779 dimerization interface [polypeptide binding]; other site 710421001780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421001781 DNA binding site [nucleotide binding] 710421001782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 710421001783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421001784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421001785 dimer interface [polypeptide binding]; other site 710421001786 phosphorylation site [posttranslational modification] 710421001787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421001788 ATP binding site [chemical binding]; other site 710421001789 Mg2+ binding site [ion binding]; other site 710421001790 G-X-G motif; other site 710421001791 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 710421001792 Predicted integral membrane protein [Function unknown]; Region: COG0392 710421001793 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710421001794 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710421001795 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710421001796 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 710421001797 LabA_like proteins; Region: LabA_like; cd06167 710421001798 putative metal binding site [ion binding]; other site 710421001799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421001800 S-adenosylmethionine binding site [chemical binding]; other site 710421001801 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 710421001802 active site 710421001803 substrate-binding site [chemical binding]; other site 710421001804 metal-binding site [ion binding] 710421001805 GTP binding site [chemical binding]; other site 710421001806 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421001807 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710421001808 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421001809 acyl-activating enzyme (AAE) consensus motif; other site 710421001810 putative AMP binding site [chemical binding]; other site 710421001811 putative active site [active] 710421001812 acyl-activating enzyme (AAE) consensus motif; other site 710421001813 putative CoA binding site [chemical binding]; other site 710421001814 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421001815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421001816 substrate binding site [chemical binding]; other site 710421001817 oxyanion hole (OAH) forming residues; other site 710421001818 trimer interface [polypeptide binding]; other site 710421001819 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 710421001820 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421001821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421001822 active site 710421001823 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421001824 active site 2 [active] 710421001825 active site 1 [active] 710421001826 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421001827 active site 2 [active] 710421001828 active site 1 [active] 710421001829 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421001830 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421001831 active site 710421001832 Amidohydrolase family; Region: Amidohydro_3; pfam07969 710421001833 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421001834 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421001835 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421001836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421001837 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421001838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421001839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421001840 active site 710421001841 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710421001842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421001843 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421001844 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421001845 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421001846 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710421001847 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710421001848 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421001849 acyl-CoA synthetase; Provisional; Region: PRK13382 710421001850 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421001851 acyl-activating enzyme (AAE) consensus motif; other site 710421001852 putative AMP binding site [chemical binding]; other site 710421001853 putative active site [active] 710421001854 putative CoA binding site [chemical binding]; other site 710421001855 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421001856 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710421001857 putative acyl-acceptor binding pocket; other site 710421001858 short chain dehydrogenase; Validated; Region: PRK08264 710421001859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421001860 NAD(P) binding site [chemical binding]; other site 710421001861 active site 710421001862 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421001863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421001864 DinB superfamily; Region: DinB_2; pfam12867 710421001865 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710421001866 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710421001867 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710421001868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421001869 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 710421001870 FAD binding site [chemical binding]; other site 710421001871 substrate binding site [chemical binding]; other site 710421001872 catalytic residues [active] 710421001873 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710421001874 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 710421001875 SnoaL-like domain; Region: SnoaL_3; pfam13474 710421001876 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710421001877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421001878 NAD binding site [chemical binding]; other site 710421001879 catalytic residues [active] 710421001880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421001881 S-adenosylmethionine binding site [chemical binding]; other site 710421001882 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421001883 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421001884 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710421001885 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 710421001886 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710421001887 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421001888 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 710421001889 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421001890 putative AMP binding site [chemical binding]; other site 710421001891 putative active site [active] 710421001892 acyl-activating enzyme (AAE) consensus motif; other site 710421001893 putative CoA binding site [chemical binding]; other site 710421001894 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 710421001895 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 710421001896 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 710421001897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421001898 Ligand Binding Site [chemical binding]; other site 710421001899 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 710421001900 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 710421001901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421001902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421001903 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421001904 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421001905 active site 2 [active] 710421001906 active site 1 [active] 710421001907 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 710421001908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421001909 NAD(P) binding site [chemical binding]; other site 710421001910 active site 710421001911 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 710421001912 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421001913 dimer interface [polypeptide binding]; other site 710421001914 active site 710421001915 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710421001916 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421001917 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 710421001918 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 710421001919 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 710421001920 FAD binding site [chemical binding]; other site 710421001921 substrate binding site [chemical binding]; other site 710421001922 catalytic residues [active] 710421001923 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 710421001924 short chain dehydrogenase; Provisional; Region: PRK08267 710421001925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421001926 NAD(P) binding site [chemical binding]; other site 710421001927 active site 710421001928 TspO/MBR family; Region: TspO_MBR; pfam03073 710421001929 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710421001930 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421001931 active site 710421001932 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710421001933 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421001934 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 710421001935 KR domain; Region: KR; pfam08659 710421001936 NADP binding site [chemical binding]; other site 710421001937 active site 710421001938 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421001939 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710421001940 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421001941 active site 710421001942 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421001943 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710421001944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421001945 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 710421001946 Enoylreductase; Region: PKS_ER; smart00829 710421001947 NAD(P) binding site [chemical binding]; other site 710421001948 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710421001949 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710421001950 putative NADP binding site [chemical binding]; other site 710421001951 active site 710421001952 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421001953 Condensation domain; Region: Condensation; pfam00668 710421001954 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421001955 acyl-CoA synthetase; Validated; Region: PRK05850 710421001956 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710421001957 acyl-activating enzyme (AAE) consensus motif; other site 710421001958 active site 710421001959 PE-PPE domain; Region: PE-PPE; pfam08237 710421001960 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710421001961 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710421001962 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 710421001963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421001964 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421001965 active site 710421001966 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 710421001967 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421001968 catalytic loop [active] 710421001969 iron binding site [ion binding]; other site 710421001970 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 710421001971 L-aspartate oxidase; Provisional; Region: PRK06175 710421001972 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710421001973 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710421001974 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 710421001975 tetramer interface [polypeptide binding]; other site 710421001976 active site 710421001977 Mg2+/Mn2+ binding site [ion binding]; other site 710421001978 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421001979 Ligand Binding Site [chemical binding]; other site 710421001980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421001981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421001982 metal binding site [ion binding]; metal-binding site 710421001983 active site 710421001984 I-site; other site 710421001985 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710421001986 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710421001987 putative dimer interface [polypeptide binding]; other site 710421001988 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 710421001989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421001990 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 710421001991 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710421001992 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 710421001993 4Fe-4S binding domain; Region: Fer4; cl02805 710421001994 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 710421001995 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 710421001996 putative active site [active] 710421001997 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 710421001998 putative active site [active] 710421001999 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 710421002000 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 710421002001 active site 710421002002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 710421002003 DNA binding site [nucleotide binding] 710421002004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421002005 Coenzyme A binding pocket [chemical binding]; other site 710421002006 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 710421002007 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 710421002008 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 710421002009 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 710421002010 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 710421002011 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710421002012 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 710421002013 intersubunit interface [polypeptide binding]; other site 710421002014 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710421002015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002016 Lysine efflux permease [General function prediction only]; Region: COG1279 710421002017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 710421002018 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 710421002019 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710421002020 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 710421002021 metal binding site [ion binding]; metal-binding site 710421002022 putative dimer interface [polypeptide binding]; other site 710421002023 Predicted membrane protein [Function unknown]; Region: COG2860 710421002024 UPF0126 domain; Region: UPF0126; pfam03458 710421002025 UPF0126 domain; Region: UPF0126; pfam03458 710421002026 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710421002027 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 710421002028 Radical SAM superfamily; Region: Radical_SAM; pfam04055 710421002029 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710421002030 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 710421002031 GAF domain; Region: GAF; pfam01590 710421002032 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421002033 short chain dehydrogenase; Validated; Region: PRK08589 710421002034 classical (c) SDRs; Region: SDR_c; cd05233 710421002035 NAD(P) binding site [chemical binding]; other site 710421002036 active site 710421002037 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710421002038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002039 NAD(P) binding site [chemical binding]; other site 710421002040 active site 710421002041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002043 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710421002044 Cutinase; Region: Cutinase; pfam01083 710421002045 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 710421002046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421002047 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 710421002048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421002049 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 710421002050 dimerization interface [polypeptide binding]; other site 710421002051 substrate binding pocket [chemical binding]; other site 710421002052 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 710421002053 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421002054 dimer interface [polypeptide binding]; other site 710421002055 active site 710421002056 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 710421002057 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710421002058 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710421002059 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 710421002060 AAA ATPase domain; Region: AAA_16; pfam13191 710421002061 AAA domain; Region: AAA_22; pfam13401 710421002062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421002063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421002064 DNA binding residues [nucleotide binding] 710421002065 dimerization interface [polypeptide binding]; other site 710421002066 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 710421002067 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421002068 catalytic loop [active] 710421002069 iron binding site [ion binding]; other site 710421002070 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 710421002071 FAD binding pocket [chemical binding]; other site 710421002072 FAD binding motif [chemical binding]; other site 710421002073 phosphate binding motif [ion binding]; other site 710421002074 beta-alpha-beta structure motif; other site 710421002075 NAD binding pocket [chemical binding]; other site 710421002076 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710421002077 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710421002078 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 710421002079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002080 NAD(P) binding site [chemical binding]; other site 710421002081 active site 710421002082 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 710421002083 inter-subunit interface; other site 710421002084 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 710421002085 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710421002086 iron-sulfur cluster [ion binding]; other site 710421002087 [2Fe-2S] cluster binding site [ion binding]; other site 710421002088 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 710421002089 putative alpha subunit interface [polypeptide binding]; other site 710421002090 putative active site [active] 710421002091 putative substrate binding site [chemical binding]; other site 710421002092 Fe binding site [ion binding]; other site 710421002093 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 710421002094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421002095 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 710421002096 dimerization interface [polypeptide binding]; other site 710421002097 substrate binding pocket [chemical binding]; other site 710421002098 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 710421002099 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 710421002100 active site 710421002101 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 710421002102 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 710421002103 active site 710421002104 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 710421002105 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 710421002106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421002107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710421002108 dimerization interface [polypeptide binding]; other site 710421002109 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 710421002110 active site 710421002111 SAM binding site [chemical binding]; other site 710421002112 homodimer interface [polypeptide binding]; other site 710421002113 cobyric acid synthase; Provisional; Region: PRK00784 710421002114 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 710421002115 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 710421002116 catalytic triad [active] 710421002117 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 710421002118 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 710421002119 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 710421002120 homotrimer interface [polypeptide binding]; other site 710421002121 Walker A motif; other site 710421002122 GTP binding site [chemical binding]; other site 710421002123 Walker B motif; other site 710421002124 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 710421002125 putative FMN binding site [chemical binding]; other site 710421002126 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 710421002127 active site 710421002128 SAM binding site [chemical binding]; other site 710421002129 homodimer interface [polypeptide binding]; other site 710421002130 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710421002131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710421002132 DNA binding site [nucleotide binding] 710421002133 domain linker motif; other site 710421002134 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 710421002135 dimerization interface [polypeptide binding]; other site 710421002136 ligand binding site [chemical binding]; other site 710421002137 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 710421002138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421002139 putative substrate translocation pore; other site 710421002140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421002141 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710421002142 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710421002143 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710421002144 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710421002145 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710421002146 Metal-binding active site; metal-binding site 710421002147 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710421002148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002150 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 710421002151 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421002152 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421002153 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421002154 active site 710421002155 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421002156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421002157 active site 710421002158 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421002159 anti sigma factor interaction site; other site 710421002160 regulatory phosphorylation site [posttranslational modification]; other site 710421002161 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 710421002162 nucleotide binding site [chemical binding]; other site 710421002163 acyl-CoA synthetase; Validated; Region: PRK07788 710421002164 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421002165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421002166 active site 710421002167 CoA binding site [chemical binding]; other site 710421002168 AMP binding site [chemical binding]; other site 710421002169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421002170 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421002171 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421002172 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710421002173 FAD binding site [chemical binding]; other site 710421002174 substrate binding site [chemical binding]; other site 710421002175 catalytic base [active] 710421002176 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 710421002177 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 710421002178 putative ligand binding site [chemical binding]; other site 710421002179 putative NAD binding site [chemical binding]; other site 710421002180 catalytic site [active] 710421002181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421002182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002184 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 710421002185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421002186 Zn binding site [ion binding]; other site 710421002187 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 710421002188 active site 1 [active] 710421002189 dimer interface [polypeptide binding]; other site 710421002190 hexamer interface [polypeptide binding]; other site 710421002191 active site 2 [active] 710421002192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002193 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 710421002194 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421002195 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421002196 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 710421002197 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421002198 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 710421002199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421002200 S-adenosylmethionine binding site [chemical binding]; other site 710421002201 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710421002202 active site 710421002203 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 710421002204 active site 710421002205 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 710421002206 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710421002207 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710421002208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 710421002209 SnoaL-like domain; Region: SnoaL_3; pfam13474 710421002210 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710421002211 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421002212 nucleotide binding site [chemical binding]; other site 710421002213 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 710421002214 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 710421002215 NAD(P) binding site [chemical binding]; other site 710421002216 LDH/MDH dimer interface [polypeptide binding]; other site 710421002217 substrate binding site [chemical binding]; other site 710421002218 hypothetical protein; Provisional; Region: PRK06185 710421002219 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421002220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002221 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421002222 NAD(P) binding site [chemical binding]; other site 710421002223 active site 710421002224 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710421002225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421002226 dimer interface [polypeptide binding]; other site 710421002227 conserved gate region; other site 710421002228 putative PBP binding loops; other site 710421002229 ABC-ATPase subunit interface; other site 710421002230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421002231 ABC-ATPase subunit interface; other site 710421002232 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710421002233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710421002234 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 710421002235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421002236 Walker A/P-loop; other site 710421002237 ATP binding site [chemical binding]; other site 710421002238 Q-loop/lid; other site 710421002239 ABC transporter signature motif; other site 710421002240 Walker B; other site 710421002241 D-loop; other site 710421002242 H-loop/switch region; other site 710421002243 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421002244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002245 NAD(P) binding site [chemical binding]; other site 710421002246 active site 710421002247 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710421002248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421002249 putative substrate translocation pore; other site 710421002250 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 710421002251 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 710421002252 active site flap/lid [active] 710421002253 nucleophilic elbow; other site 710421002254 catalytic triad [active] 710421002255 ApbE family; Region: ApbE; pfam02424 710421002256 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 710421002257 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 710421002258 SLBB domain; Region: SLBB; pfam10531 710421002259 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 710421002260 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710421002261 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710421002262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421002263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421002264 active site 710421002265 phosphorylation site [posttranslational modification] 710421002266 intermolecular recognition site; other site 710421002267 dimerization interface [polypeptide binding]; other site 710421002268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421002269 DNA binding site [nucleotide binding] 710421002270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421002271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421002272 dimer interface [polypeptide binding]; other site 710421002273 phosphorylation site [posttranslational modification] 710421002274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421002275 ATP binding site [chemical binding]; other site 710421002276 Mg2+ binding site [ion binding]; other site 710421002277 G-X-G motif; other site 710421002278 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 710421002279 FtsX-like permease family; Region: FtsX; pfam02687 710421002280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710421002281 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710421002282 Walker A/P-loop; other site 710421002283 ATP binding site [chemical binding]; other site 710421002284 Q-loop/lid; other site 710421002285 ABC transporter signature motif; other site 710421002286 Walker B; other site 710421002287 D-loop; other site 710421002288 H-loop/switch region; other site 710421002289 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 710421002290 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 710421002291 nucleophilic elbow; other site 710421002292 catalytic triad; other site 710421002293 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 710421002294 heme-binding site [chemical binding]; other site 710421002295 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 710421002296 hypothetical protein; Provisional; Region: PRK06849 710421002297 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421002298 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421002299 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710421002300 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421002301 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421002302 active site 710421002303 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710421002304 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421002305 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710421002306 acyl-activating enzyme (AAE) consensus motif; other site 710421002307 putative AMP binding site [chemical binding]; other site 710421002308 putative active site [active] 710421002309 putative CoA binding site [chemical binding]; other site 710421002310 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710421002311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421002312 Walker A motif; other site 710421002313 ATP binding site [chemical binding]; other site 710421002314 Walker B motif; other site 710421002315 Helix-turn-helix domain; Region: HTH_28; pfam13518 710421002316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421002317 Integrase core domain; Region: rve; pfam00665 710421002318 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710421002319 trimer interface [polypeptide binding]; other site 710421002320 active site 710421002321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002323 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710421002324 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 710421002325 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 710421002326 putative active site [active] 710421002327 putative metal binding site [ion binding]; other site 710421002328 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710421002329 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710421002330 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 710421002331 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710421002332 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710421002333 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710421002334 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710421002335 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421002336 Cytochrome P450; Region: p450; cl12078 710421002337 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421002338 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421002339 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421002340 YibE/F-like protein; Region: YibE_F; pfam07907 710421002341 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 710421002342 aminotransferase AlaT; Validated; Region: PRK09265 710421002343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421002344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421002345 homodimer interface [polypeptide binding]; other site 710421002346 catalytic residue [active] 710421002347 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 710421002348 4Fe-4S binding domain; Region: Fer4; cl02805 710421002349 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710421002350 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710421002351 4Fe-4S binding domain; Region: Fer4; pfam00037 710421002352 Cysteine-rich domain; Region: CCG; pfam02754 710421002353 Cysteine-rich domain; Region: CCG; pfam02754 710421002354 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421002355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421002356 DNA binding residues [nucleotide binding] 710421002357 dimerization interface [polypeptide binding]; other site 710421002358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421002359 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 710421002360 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710421002361 G1 box; other site 710421002362 GTP/Mg2+ binding site [chemical binding]; other site 710421002363 G2 box; other site 710421002364 Switch I region; other site 710421002365 G3 box; other site 710421002366 Switch II region; other site 710421002367 G4 box; other site 710421002368 G5 box; other site 710421002369 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 710421002370 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710421002371 G1 box; other site 710421002372 GTP/Mg2+ binding site [chemical binding]; other site 710421002373 G2 box; other site 710421002374 Switch I region; other site 710421002375 G3 box; other site 710421002376 Switch II region; other site 710421002377 G4 box; other site 710421002378 G5 box; other site 710421002379 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421002380 nucleotide binding site [chemical binding]; other site 710421002381 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710421002382 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421002383 TIGR03085 family protein; Region: TIGR03085 710421002384 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421002385 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710421002386 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710421002387 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 710421002388 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710421002389 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710421002390 mycothione reductase; Reviewed; Region: PRK07846 710421002391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421002392 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421002393 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 710421002394 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 710421002395 nucleotide binding site [chemical binding]; other site 710421002396 NEF interaction site [polypeptide binding]; other site 710421002397 SBD interface [polypeptide binding]; other site 710421002398 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 710421002399 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 710421002400 dimer interface [polypeptide binding]; other site 710421002401 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 710421002402 chaperone protein DnaJ; Provisional; Region: PRK14279 710421002403 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710421002404 HSP70 interaction site [polypeptide binding]; other site 710421002405 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710421002406 Zn binding sites [ion binding]; other site 710421002407 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710421002408 dimer interface [polypeptide binding]; other site 710421002409 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 710421002410 DNA binding residues [nucleotide binding] 710421002411 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710421002412 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 710421002413 active site 710421002414 catalytic residues [active] 710421002415 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 710421002416 heme-binding site [chemical binding]; other site 710421002417 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 710421002418 FMN reductase; Validated; Region: fre; PRK08051 710421002419 FAD binding pocket [chemical binding]; other site 710421002420 FAD binding motif [chemical binding]; other site 710421002421 phosphate binding motif [ion binding]; other site 710421002422 beta-alpha-beta structure motif; other site 710421002423 NAD binding pocket [chemical binding]; other site 710421002424 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 710421002425 putative active site [active] 710421002426 putative metal binding residues [ion binding]; other site 710421002427 signature motif; other site 710421002428 putative dimer interface [polypeptide binding]; other site 710421002429 putative phosphate binding site [ion binding]; other site 710421002430 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 710421002431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 710421002432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421002433 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710421002434 active site 710421002435 metal binding site [ion binding]; metal-binding site 710421002436 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 710421002437 Clp amino terminal domain; Region: Clp_N; pfam02861 710421002438 Clp amino terminal domain; Region: Clp_N; pfam02861 710421002439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421002440 Walker A motif; other site 710421002441 ATP binding site [chemical binding]; other site 710421002442 Walker B motif; other site 710421002443 arginine finger; other site 710421002444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421002445 Walker A motif; other site 710421002446 ATP binding site [chemical binding]; other site 710421002447 Walker B motif; other site 710421002448 arginine finger; other site 710421002449 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710421002450 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421002451 classical (c) SDRs; Region: SDR_c; cd05233 710421002452 NAD(P) binding site [chemical binding]; other site 710421002453 active site 710421002454 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710421002455 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 710421002456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421002457 putative substrate translocation pore; other site 710421002458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002459 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 710421002460 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 710421002461 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710421002462 Thioredoxin; Region: Thioredoxin_4; pfam13462 710421002463 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 710421002464 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710421002465 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710421002466 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710421002467 NAD(P) binding site [chemical binding]; other site 710421002468 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 710421002469 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 710421002470 active site 710421002471 intersubunit interface [polypeptide binding]; other site 710421002472 zinc binding site [ion binding]; other site 710421002473 Na+ binding site [ion binding]; other site 710421002474 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710421002475 AAA ATPase domain; Region: AAA_16; pfam13191 710421002476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421002477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421002478 DNA binding residues [nucleotide binding] 710421002479 dimerization interface [polypeptide binding]; other site 710421002480 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 710421002481 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710421002482 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 710421002483 Peptidase family M50; Region: Peptidase_M50; pfam02163 710421002484 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 710421002485 active site 710421002486 putative substrate binding region [chemical binding]; other site 710421002487 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 710421002488 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 710421002489 GDP-binding site [chemical binding]; other site 710421002490 ACT binding site; other site 710421002491 IMP binding site; other site 710421002492 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421002493 CoenzymeA binding site [chemical binding]; other site 710421002494 subunit interaction site [polypeptide binding]; other site 710421002495 PHB binding site; other site 710421002496 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 710421002497 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710421002498 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421002499 Cytochrome P450; Region: p450; cl12078 710421002500 MMPL family; Region: MMPL; pfam03176 710421002501 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710421002502 MarR family; Region: MarR_2; pfam12802 710421002503 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 710421002504 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 710421002505 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421002506 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 710421002507 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710421002508 active site residue [active] 710421002509 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 710421002510 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710421002511 homodimer interface [polypeptide binding]; other site 710421002512 substrate-cofactor binding pocket; other site 710421002513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421002514 catalytic residue [active] 710421002515 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421002516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002518 short chain dehydrogenase; Provisional; Region: PRK07825 710421002519 classical (c) SDRs; Region: SDR_c; cd05233 710421002520 NAD(P) binding site [chemical binding]; other site 710421002521 active site 710421002522 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710421002523 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710421002524 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421002525 putative DNA binding site [nucleotide binding]; other site 710421002526 putative Zn2+ binding site [ion binding]; other site 710421002527 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 710421002528 putative hydrophobic ligand binding site [chemical binding]; other site 710421002529 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421002530 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 710421002531 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421002532 active site 710421002533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421002534 Coenzyme A binding pocket [chemical binding]; other site 710421002535 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710421002536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421002537 S-adenosylmethionine binding site [chemical binding]; other site 710421002538 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421002539 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 710421002540 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710421002541 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421002542 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710421002543 putative catalytic site [active] 710421002544 putative metal binding site [ion binding]; other site 710421002545 putative phosphate binding site [ion binding]; other site 710421002546 phosphate acetyltransferase; Reviewed; Region: PRK05632 710421002547 DRTGG domain; Region: DRTGG; pfam07085 710421002548 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 710421002549 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 710421002550 propionate/acetate kinase; Provisional; Region: PRK12379 710421002551 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421002552 anti sigma factor interaction site; other site 710421002553 regulatory phosphorylation site [posttranslational modification]; other site 710421002554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421002555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421002556 active site 710421002557 ATP binding site [chemical binding]; other site 710421002558 substrate binding site [chemical binding]; other site 710421002559 activation loop (A-loop); other site 710421002560 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421002561 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421002562 substrate binding pocket [chemical binding]; other site 710421002563 membrane-bound complex binding site; other site 710421002564 hinge residues; other site 710421002565 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 710421002566 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 710421002567 nudix motif; other site 710421002568 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 710421002569 thiamine phosphate binding site [chemical binding]; other site 710421002570 active site 710421002571 pyrophosphate binding site [ion binding]; other site 710421002572 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 710421002573 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 710421002574 thiS-thiF/thiG interaction site; other site 710421002575 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 710421002576 ThiS interaction site; other site 710421002577 putative active site [active] 710421002578 tetramer interface [polypeptide binding]; other site 710421002579 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 710421002580 active site 710421002581 catalytic triad [active] 710421002582 oxyanion hole [active] 710421002583 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710421002584 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 710421002585 Walker A/P-loop; other site 710421002586 ATP binding site [chemical binding]; other site 710421002587 Q-loop/lid; other site 710421002588 ABC transporter signature motif; other site 710421002589 Walker B; other site 710421002590 D-loop; other site 710421002591 H-loop/switch region; other site 710421002592 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421002593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421002594 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421002595 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 710421002596 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710421002597 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 710421002598 PA/protease or protease-like domain interface [polypeptide binding]; other site 710421002599 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 710421002600 active site 710421002601 metal binding site [ion binding]; metal-binding site 710421002602 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710421002603 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 710421002604 PA/protease or protease-like domain interface [polypeptide binding]; other site 710421002605 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 710421002606 Peptidase family M28; Region: Peptidase_M28; pfam04389 710421002607 active site 710421002608 metal binding site [ion binding]; metal-binding site 710421002609 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 710421002610 MarR family; Region: MarR_2; cl17246 710421002611 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 710421002612 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 710421002613 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421002614 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421002615 K+-transporting ATPase, c chain; Region: KdpC; cl00944 710421002616 K+-transporting ATPase, c chain; Region: KdpC; cl00944 710421002617 amino acid transporter; Region: 2A0306; TIGR00909 710421002618 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421002619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421002620 Septum formation; Region: Septum_form; pfam13845 710421002621 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 710421002622 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 710421002623 dimer interface [polypeptide binding]; other site 710421002624 substrate binding site [chemical binding]; other site 710421002625 ATP binding site [chemical binding]; other site 710421002626 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 710421002627 ThiC-associated domain; Region: ThiC-associated; pfam13667 710421002628 ThiC family; Region: ThiC; pfam01964 710421002629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421002630 putative substrate translocation pore; other site 710421002631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421002632 putative substrate translocation pore; other site 710421002633 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421002634 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710421002635 putative acyl-acceptor binding pocket; other site 710421002636 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 710421002637 putative catalytic site [active] 710421002638 putative phosphate binding site [ion binding]; other site 710421002639 active site 710421002640 metal binding site A [ion binding]; metal-binding site 710421002641 DNA binding site [nucleotide binding] 710421002642 putative AP binding site [nucleotide binding]; other site 710421002643 putative metal binding site B [ion binding]; other site 710421002644 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710421002645 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 710421002646 active site 710421002647 catalytic residues [active] 710421002648 metal binding site [ion binding]; metal-binding site 710421002649 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 710421002650 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710421002651 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 710421002652 E-class dimer interface [polypeptide binding]; other site 710421002653 P-class dimer interface [polypeptide binding]; other site 710421002654 active site 710421002655 Cu2+ binding site [ion binding]; other site 710421002656 Zn2+ binding site [ion binding]; other site 710421002657 carboxylate-amine ligase; Provisional; Region: PRK13517 710421002658 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710421002659 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 710421002660 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 710421002661 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421002662 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421002663 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 710421002664 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 710421002665 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 710421002666 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 710421002667 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421002668 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 710421002669 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 710421002670 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 710421002671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421002672 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 710421002673 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 710421002674 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710421002675 TrkA-N domain; Region: TrkA_N; pfam02254 710421002676 TrkA-C domain; Region: TrkA_C; pfam02080 710421002677 potassium/proton antiporter; Reviewed; Region: PRK05326 710421002678 TrkA-C domain; Region: TrkA_C; pfam02080 710421002679 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710421002680 2TM domain; Region: 2TM; pfam13239 710421002681 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 710421002682 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 710421002683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421002684 Walker A motif; other site 710421002685 ATP binding site [chemical binding]; other site 710421002686 Walker B motif; other site 710421002687 arginine finger; other site 710421002688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421002689 Walker A motif; other site 710421002690 ATP binding site [chemical binding]; other site 710421002691 Walker B motif; other site 710421002692 arginine finger; other site 710421002693 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 710421002694 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 710421002695 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 710421002696 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710421002697 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710421002698 dimer interface [polypeptide binding]; other site 710421002699 putative functional site; other site 710421002700 putative MPT binding site; other site 710421002701 short chain dehydrogenase; Provisional; Region: PRK06197 710421002702 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710421002703 putative NAD(P) binding site [chemical binding]; other site 710421002704 active site 710421002705 Uncharacterized conserved protein [Function unknown]; Region: COG3402 710421002706 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710421002707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421002708 active site 710421002709 motif I; other site 710421002710 motif II; other site 710421002711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421002712 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 710421002713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421002714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421002715 DNA binding residues [nucleotide binding] 710421002716 dimerization interface [polypeptide binding]; other site 710421002717 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 710421002718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421002719 ATP binding site [chemical binding]; other site 710421002720 putative Mg++ binding site [ion binding]; other site 710421002721 Cupin domain; Region: Cupin_2; pfam07883 710421002722 PE-PPE domain; Region: PE-PPE; pfam08237 710421002723 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 710421002724 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 710421002725 hypothetical protein; Provisional; Region: PRK13685 710421002726 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710421002727 metal ion-dependent adhesion site (MIDAS); other site 710421002728 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710421002729 metal ion-dependent adhesion site (MIDAS); other site 710421002730 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710421002731 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710421002732 ring oligomerisation interface [polypeptide binding]; other site 710421002733 ATP/Mg binding site [chemical binding]; other site 710421002734 stacking interactions; other site 710421002735 hinge regions; other site 710421002736 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710421002737 DinB superfamily; Region: DinB_2; pfam12867 710421002738 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710421002739 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421002740 classical (c) SDRs; Region: SDR_c; cd05233 710421002741 NAD(P) binding site [chemical binding]; other site 710421002742 active site 710421002743 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421002744 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421002745 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710421002746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002747 NAD(P) binding site [chemical binding]; other site 710421002748 active site 710421002749 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710421002750 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 710421002751 active site 710421002752 putative substrate binding pocket [chemical binding]; other site 710421002753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421002754 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 710421002755 putative hydrophobic ligand binding site [chemical binding]; other site 710421002756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421002757 dimerization interface [polypeptide binding]; other site 710421002758 putative DNA binding site [nucleotide binding]; other site 710421002759 putative Zn2+ binding site [ion binding]; other site 710421002760 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710421002761 DinB superfamily; Region: DinB_2; pfam12867 710421002762 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421002763 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 710421002764 NAD(P) binding site [chemical binding]; other site 710421002765 catalytic residues [active] 710421002766 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 710421002767 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 710421002768 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710421002769 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421002770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421002771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421002772 DNA binding residues [nucleotide binding] 710421002773 dimerization interface [polypeptide binding]; other site 710421002774 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421002775 Cytochrome P450; Region: p450; cl12078 710421002776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421002777 ATP binding site [chemical binding]; other site 710421002778 putative Mg++ binding site [ion binding]; other site 710421002779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421002780 nucleotide binding region [chemical binding]; other site 710421002781 ATP-binding site [chemical binding]; other site 710421002782 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 710421002783 enoyl-CoA hydratase; Provisional; Region: PRK12478 710421002784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421002785 substrate binding site [chemical binding]; other site 710421002786 oxyanion hole (OAH) forming residues; other site 710421002787 trimer interface [polypeptide binding]; other site 710421002788 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 710421002789 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421002790 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421002791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421002792 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421002793 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 710421002794 putative NAD(P) binding site [chemical binding]; other site 710421002795 catalytic Zn binding site [ion binding]; other site 710421002796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002797 acetoin reductases; Region: 23BDH; TIGR02415 710421002798 NAD(P) binding site [chemical binding]; other site 710421002799 active site 710421002800 GAF domain; Region: GAF; pfam01590 710421002801 Protein of unknown function (DUF779); Region: DUF779; pfam05610 710421002802 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 710421002803 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 710421002804 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 710421002805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421002806 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421002807 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421002808 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710421002809 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710421002810 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421002811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421002812 non-specific DNA binding site [nucleotide binding]; other site 710421002813 salt bridge; other site 710421002814 sequence-specific DNA binding site [nucleotide binding]; other site 710421002815 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 710421002816 Domain of unknown function (DUF955); Region: DUF955; pfam06114 710421002817 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 710421002818 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421002819 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 710421002820 active site 2 [active] 710421002821 active site 1 [active] 710421002822 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421002823 active site 2 [active] 710421002824 isocitrate lyase; Provisional; Region: PRK15063 710421002825 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710421002826 tetramer interface [polypeptide binding]; other site 710421002827 active site 710421002828 Mg2+/Mn2+ binding site [ion binding]; other site 710421002829 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 710421002830 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710421002831 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710421002832 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 710421002833 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 710421002834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002836 Predicted membrane protein [Function unknown]; Region: COG2733 710421002837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421002838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421002839 non-specific DNA binding site [nucleotide binding]; other site 710421002840 salt bridge; other site 710421002841 sequence-specific DNA binding site [nucleotide binding]; other site 710421002842 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 710421002843 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 710421002844 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 710421002845 catalytic residue [active] 710421002846 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421002847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421002848 non-specific DNA binding site [nucleotide binding]; other site 710421002849 salt bridge; other site 710421002850 sequence-specific DNA binding site [nucleotide binding]; other site 710421002851 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710421002852 active site 710421002853 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710421002854 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710421002855 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 710421002856 putative active site [active] 710421002857 catalytic triad [active] 710421002858 putative dimer interface [polypeptide binding]; other site 710421002859 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710421002860 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 710421002861 FAD binding domain; Region: FAD_binding_4; pfam01565 710421002862 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 710421002863 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710421002864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421002865 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710421002866 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421002867 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710421002868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002869 NAD(P) binding site [chemical binding]; other site 710421002870 active site 710421002871 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710421002872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421002873 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 710421002874 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 710421002875 putative ADP-binding pocket [chemical binding]; other site 710421002876 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 710421002877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421002878 catalytic core [active] 710421002879 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421002880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421002881 dimer interface [polypeptide binding]; other site 710421002882 phosphorylation site [posttranslational modification] 710421002883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421002884 ATP binding site [chemical binding]; other site 710421002885 Mg2+ binding site [ion binding]; other site 710421002886 G-X-G motif; other site 710421002887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421002888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421002889 active site 710421002890 phosphorylation site [posttranslational modification] 710421002891 intermolecular recognition site; other site 710421002892 dimerization interface [polypeptide binding]; other site 710421002893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421002894 DNA binding site [nucleotide binding] 710421002895 YCII-related domain; Region: YCII; pfam03795 710421002896 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710421002897 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710421002898 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 710421002899 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 710421002900 DNA interaction; other site 710421002901 Metal-binding active site; metal-binding site 710421002902 AP (apurinic/apyrimidinic) site pocket; other site 710421002903 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710421002904 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 710421002905 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 710421002906 DNA binding domain, excisionase family; Region: excise; TIGR01764 710421002907 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421002908 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 710421002909 putative NAD(P) binding site [chemical binding]; other site 710421002910 active site 710421002911 putative substrate binding site [chemical binding]; other site 710421002912 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421002913 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710421002914 putative acyl-acceptor binding pocket; other site 710421002915 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710421002916 active site 710421002917 catalytic site [active] 710421002918 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710421002919 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710421002920 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 710421002921 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 710421002922 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 710421002923 tRNA; other site 710421002924 putative tRNA binding site [nucleotide binding]; other site 710421002925 putative NADP binding site [chemical binding]; other site 710421002926 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 710421002927 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 710421002928 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 710421002929 domain interfaces; other site 710421002930 active site 710421002931 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 710421002932 homodimer interface [polypeptide binding]; other site 710421002933 active site 710421002934 SAM binding site [chemical binding]; other site 710421002935 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 710421002936 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 710421002937 active site 710421002938 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 710421002939 dimer interface [polypeptide binding]; other site 710421002940 active site 710421002941 Schiff base residues; other site 710421002942 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710421002943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421002944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421002945 Cytochrome P450; Region: p450; cl12078 710421002946 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421002947 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421002948 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421002949 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 710421002950 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421002951 inhibitor-cofactor binding pocket; inhibition site 710421002952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421002953 catalytic residue [active] 710421002954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421002955 catalytic core [active] 710421002956 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710421002957 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421002958 catalytic residues [active] 710421002959 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 710421002960 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710421002961 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 710421002962 ResB-like family; Region: ResB; pfam05140 710421002963 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 710421002964 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421002965 AAA domain; Region: AAA_31; pfam13614 710421002966 P-loop; other site 710421002967 Magnesium ion binding site [ion binding]; other site 710421002968 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 710421002969 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421002970 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710421002971 Protein of unknown function DUF58; Region: DUF58; pfam01882 710421002972 MoxR-like ATPases [General function prediction only]; Region: COG0714 710421002973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421002974 Walker A motif; other site 710421002975 ATP binding site [chemical binding]; other site 710421002976 Walker B motif; other site 710421002977 arginine finger; other site 710421002978 YrhK-like protein; Region: YrhK; pfam14145 710421002979 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 710421002980 UbiA prenyltransferase family; Region: UbiA; pfam01040 710421002981 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 710421002982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421002983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421002984 NAD(P) binding site [chemical binding]; other site 710421002985 active site 710421002986 Nitronate monooxygenase; Region: NMO; pfam03060 710421002987 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710421002988 FMN binding site [chemical binding]; other site 710421002989 substrate binding site [chemical binding]; other site 710421002990 putative catalytic residue [active] 710421002991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421002992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421002993 dimer interface [polypeptide binding]; other site 710421002994 phosphorylation site [posttranslational modification] 710421002995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421002996 ATP binding site [chemical binding]; other site 710421002997 Mg2+ binding site [ion binding]; other site 710421002998 G-X-G motif; other site 710421002999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421003000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421003001 active site 710421003002 phosphorylation site [posttranslational modification] 710421003003 intermolecular recognition site; other site 710421003004 dimerization interface [polypeptide binding]; other site 710421003005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421003006 DNA binding site [nucleotide binding] 710421003007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421003008 active site 710421003009 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 710421003010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421003011 S-adenosylmethionine binding site [chemical binding]; other site 710421003012 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 710421003013 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710421003014 Moco binding site; other site 710421003015 metal coordination site [ion binding]; other site 710421003016 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710421003017 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 710421003018 putative active site [active] 710421003019 catalytic site [active] 710421003020 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 710421003021 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710421003022 putative active site [active] 710421003023 putative active site [active] 710421003024 catalytic site [active] 710421003025 catalytic site [active] 710421003026 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 710421003027 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421003028 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421003029 acyl-activating enzyme (AAE) consensus motif; other site 710421003030 acyl-activating enzyme (AAE) consensus motif; other site 710421003031 AMP binding site [chemical binding]; other site 710421003032 active site 710421003033 CoA binding site [chemical binding]; other site 710421003034 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710421003035 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 710421003036 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710421003037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421003038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710421003039 active site 710421003040 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710421003041 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421003042 acyl-activating enzyme (AAE) consensus motif; other site 710421003043 putative AMP binding site [chemical binding]; other site 710421003044 putative active site [active] 710421003045 putative CoA binding site [chemical binding]; other site 710421003046 short chain dehydrogenase; Provisional; Region: PRK05866 710421003047 classical (c) SDRs; Region: SDR_c; cd05233 710421003048 NAD(P) binding site [chemical binding]; other site 710421003049 active site 710421003050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421003051 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710421003052 substrate binding site [chemical binding]; other site 710421003053 oxyanion hole (OAH) forming residues; other site 710421003054 trimer interface [polypeptide binding]; other site 710421003055 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421003056 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 710421003057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421003058 motif II; other site 710421003059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421003060 active site 710421003061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421003062 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 710421003063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710421003064 acyl-CoA synthetase; Validated; Region: PRK06188 710421003065 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421003066 putative active site [active] 710421003067 putative CoA binding site [chemical binding]; other site 710421003068 putative AMP binding site [chemical binding]; other site 710421003069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421003070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421003072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003073 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710421003074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003075 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710421003076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421003077 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421003078 acyl-activating enzyme (AAE) consensus motif; other site 710421003079 acyl-activating enzyme (AAE) consensus motif; other site 710421003080 putative AMP binding site [chemical binding]; other site 710421003081 putative active site [active] 710421003082 putative CoA binding site [chemical binding]; other site 710421003083 SOUL heme-binding protein; Region: SOUL; pfam04832 710421003084 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 710421003085 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 710421003086 O-succinylbenzoate synthase; Provisional; Region: PRK02901 710421003087 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 710421003088 active site 710421003089 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 710421003090 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710421003091 conserved cys residue [active] 710421003092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421003093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421003094 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 710421003095 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 710421003096 conserved cys residue [active] 710421003097 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421003098 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710421003099 TAP-like protein; Region: Abhydrolase_4; pfam08386 710421003100 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 710421003101 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 710421003102 dimer interface [polypeptide binding]; other site 710421003103 tetramer interface [polypeptide binding]; other site 710421003104 PYR/PP interface [polypeptide binding]; other site 710421003105 TPP binding site [chemical binding]; other site 710421003106 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 710421003107 TPP-binding site; other site 710421003108 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 710421003109 Thioredoxin; Region: Thioredoxin_4; cl17273 710421003110 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421003111 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 710421003112 Protein of unknown function (DUF421); Region: DUF421; pfam04239 710421003113 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710421003114 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421003115 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710421003116 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421003117 short chain dehydrogenase; Provisional; Region: PRK08263 710421003118 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710421003119 NADP binding site [chemical binding]; other site 710421003120 active site 710421003121 steroid binding site; other site 710421003122 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 710421003123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421003124 S-adenosylmethionine binding site [chemical binding]; other site 710421003125 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421003126 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421003127 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710421003128 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710421003129 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710421003130 substrate binding pocket [chemical binding]; other site 710421003131 chain length determination region; other site 710421003132 substrate-Mg2+ binding site; other site 710421003133 catalytic residues [active] 710421003134 aspartate-rich region 1; other site 710421003135 active site lid residues [active] 710421003136 aspartate-rich region 2; other site 710421003137 heat shock protein HtpX; Provisional; Region: PRK03072 710421003138 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 710421003139 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710421003140 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710421003141 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710421003142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 710421003143 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 710421003144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 710421003145 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710421003146 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710421003147 ligand binding site [chemical binding]; other site 710421003148 flexible hinge region; other site 710421003149 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710421003150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421003151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421003152 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 710421003153 Phosphoesterase family; Region: Phosphoesterase; pfam04185 710421003154 MspA; Region: MspA; pfam09203 710421003155 Gas vesicle protein K; Region: GvpK; pfam05121 710421003156 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 710421003157 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 710421003158 Gas vesicle protein; Region: Gas_vesicle; pfam00741 710421003159 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 710421003160 Gas vesicle protein G; Region: GvpG; pfam05120 710421003161 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 710421003162 Gas vesicle protein; Region: Gas_vesicle; cl02954 710421003163 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 710421003164 putative hydrophobic ligand binding site [chemical binding]; other site 710421003165 CsbD-like; Region: CsbD; pfam05532 710421003166 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710421003167 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710421003168 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 710421003169 Walker A/P-loop; other site 710421003170 ATP binding site [chemical binding]; other site 710421003171 Q-loop/lid; other site 710421003172 ABC transporter signature motif; other site 710421003173 Walker B; other site 710421003174 D-loop; other site 710421003175 H-loop/switch region; other site 710421003176 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 710421003177 PLD-like domain; Region: PLDc_2; pfam13091 710421003178 putative active site [active] 710421003179 putative catalytic site [active] 710421003180 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 710421003181 PLD-like domain; Region: PLDc_2; pfam13091 710421003182 putative active site [active] 710421003183 putative catalytic site [active] 710421003184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421003185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421003186 putative substrate translocation pore; other site 710421003187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003188 Ligand Binding Site [chemical binding]; other site 710421003189 PE-PPE domain; Region: PE-PPE; pfam08237 710421003190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421003191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421003192 active site 710421003193 phosphorylation site [posttranslational modification] 710421003194 intermolecular recognition site; other site 710421003195 dimerization interface [polypeptide binding]; other site 710421003196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421003197 DNA binding residues [nucleotide binding] 710421003198 dimerization interface [polypeptide binding]; other site 710421003199 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 710421003200 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421003201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421003202 catalytic residue [active] 710421003203 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 710421003204 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 710421003205 putative ligand binding site [chemical binding]; other site 710421003206 NAD binding site [chemical binding]; other site 710421003207 catalytic site [active] 710421003208 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421003209 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 710421003210 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 710421003211 dimer interface [polypeptide binding]; other site 710421003212 NADP binding site [chemical binding]; other site 710421003213 catalytic residues [active] 710421003214 Predicted transcriptional regulators [Transcription]; Region: COG1733 710421003215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421003216 dimerization interface [polypeptide binding]; other site 710421003217 putative DNA binding site [nucleotide binding]; other site 710421003218 putative Zn2+ binding site [ion binding]; other site 710421003219 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421003220 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421003221 active site 710421003222 ATP binding site [chemical binding]; other site 710421003223 substrate binding site [chemical binding]; other site 710421003224 activation loop (A-loop); other site 710421003225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421003226 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421003227 substrate binding pocket [chemical binding]; other site 710421003228 membrane-bound complex binding site; other site 710421003229 hinge residues; other site 710421003230 Chromate transporter; Region: Chromate_transp; pfam02417 710421003231 Chromate transporter; Region: Chromate_transp; pfam02417 710421003232 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 710421003233 PLD-like domain; Region: PLDc_2; pfam13091 710421003234 putative active site [active] 710421003235 putative catalytic site [active] 710421003236 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 710421003237 PLD-like domain; Region: PLDc_2; pfam13091 710421003238 putative active site [active] 710421003239 putative catalytic site [active] 710421003240 MspA; Region: MspA; pfam09203 710421003241 MspA; Region: MspA; pfam09203 710421003242 PknH-like extracellular domain; Region: PknH_C; pfam14032 710421003243 MMPL family; Region: MMPL; pfam03176 710421003244 MMPL family; Region: MMPL; pfam03176 710421003245 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421003246 Cytochrome P450; Region: p450; cl12078 710421003247 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 710421003248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421003249 acyl-activating enzyme (AAE) consensus motif; other site 710421003250 AMP binding site [chemical binding]; other site 710421003251 active site 710421003252 CoA binding site [chemical binding]; other site 710421003253 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710421003254 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710421003255 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 710421003256 active site 710421003257 catalytic residues [active] 710421003258 DinB superfamily; Region: DinB_2; pfam12867 710421003259 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421003260 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710421003261 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710421003262 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710421003263 DNA-binding site [nucleotide binding]; DNA binding site 710421003264 RNA-binding motif; other site 710421003265 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421003266 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421003267 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421003268 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421003269 active site 710421003270 ATP binding site [chemical binding]; other site 710421003271 substrate binding site [chemical binding]; other site 710421003272 activation loop (A-loop); other site 710421003273 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 710421003274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421003275 putative substrate translocation pore; other site 710421003276 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421003277 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710421003278 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710421003279 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421003280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 710421003281 active site 710421003282 dimerization interface [polypeptide binding]; other site 710421003283 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421003284 DNA binding residues [nucleotide binding] 710421003285 dimerization interface [polypeptide binding]; other site 710421003286 Transglycosylase; Region: Transgly; pfam00912 710421003287 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 710421003288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710421003289 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710421003290 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710421003291 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421003292 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421003293 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421003294 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710421003295 phosphopeptide binding site; other site 710421003296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421003297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 710421003298 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421003299 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421003300 active site 710421003301 ATP binding site [chemical binding]; other site 710421003302 substrate binding site [chemical binding]; other site 710421003303 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 710421003304 substrate binding site [chemical binding]; other site 710421003305 activation loop (A-loop); other site 710421003306 activation loop (A-loop); other site 710421003307 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 710421003308 Kelch motif; Region: Kelch_6; pfam13964 710421003309 Kelch domain; Region: Kelch; smart00612 710421003310 Kelch motif; Region: Kelch_1; pfam01344 710421003311 Galactose oxidase, central domain; Region: Kelch_3; cl02701 710421003312 Kelch domain; Region: Kelch; smart00612 710421003313 Galactose oxidase, central domain; Region: Kelch_3; cl02701 710421003314 Kelch domain; Region: Kelch; smart00612 710421003315 Kelch motif; Region: Kelch_1; pfam01344 710421003316 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 710421003317 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710421003318 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421003319 cyclase homology domain; Region: CHD; cd07302 710421003320 nucleotidyl binding site; other site 710421003321 metal binding site [ion binding]; metal-binding site 710421003322 dimer interface [polypeptide binding]; other site 710421003323 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 710421003324 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 710421003325 Protein of unknown function (DUF524); Region: DUF524; pfam04411 710421003326 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 710421003327 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421003328 active site 710421003329 PE-PPE domain; Region: PE-PPE; pfam08237 710421003330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421003331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421003333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421003334 putative substrate translocation pore; other site 710421003335 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710421003336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003337 putative transcriptional regulator; Provisional; Region: PRK11640 710421003338 Transmembrane secretion effector; Region: MFS_3; pfam05977 710421003339 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710421003340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421003342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 710421003344 P-loop containing region of AAA domain; Region: AAA_29; cl17516 710421003345 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 710421003346 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 710421003347 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 710421003348 Fic/DOC family; Region: Fic; cl00960 710421003349 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 710421003350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421003351 Protein of unknown function, DUF488; Region: DUF488; pfam04343 710421003352 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 710421003353 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710421003354 FMN binding site [chemical binding]; other site 710421003355 substrate binding site [chemical binding]; other site 710421003356 putative catalytic residue [active] 710421003357 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710421003358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421003359 DNA-binding site [nucleotide binding]; DNA binding site 710421003360 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710421003361 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 710421003362 YceI-like domain; Region: YceI; smart00867 710421003363 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 710421003364 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421003365 molybdopterin cofactor binding site; other site 710421003366 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421003367 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421003368 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710421003369 molybdopterin cofactor binding site; other site 710421003370 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 710421003371 4Fe-4S binding domain; Region: Fer4_6; pfam12837 710421003372 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 710421003373 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710421003374 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 710421003375 Sulfate transporter family; Region: Sulfate_transp; pfam00916 710421003376 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 710421003377 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 710421003378 DNA binding residues [nucleotide binding] 710421003379 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710421003380 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421003381 hypothetical protein; Provisional; Region: PRK06834 710421003382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710421003383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421003384 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710421003385 DNA-binding site [nucleotide binding]; DNA binding site 710421003386 RNA-binding motif; other site 710421003387 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710421003388 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710421003389 ATP binding site [chemical binding]; other site 710421003390 Mg++ binding site [ion binding]; other site 710421003391 motif III; other site 710421003392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421003393 nucleotide binding region [chemical binding]; other site 710421003394 ATP-binding site [chemical binding]; other site 710421003395 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 710421003396 active site 710421003397 catalytic residues [active] 710421003398 AAA domain; Region: AAA_30; pfam13604 710421003399 PIF1-like helicase; Region: PIF1; pfam05970 710421003400 Family description; Region: UvrD_C_2; pfam13538 710421003401 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 710421003402 Uncharacterized conserved protein [Function unknown]; Region: COG0398 710421003403 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 710421003404 AAA ATPase domain; Region: AAA_16; pfam13191 710421003405 Domain of unknown function DUF87; Region: DUF87; pfam01935 710421003406 AAA-like domain; Region: AAA_10; pfam12846 710421003407 Zonular occludens toxin (Zot); Region: Zot; cl17485 710421003408 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 710421003409 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 710421003410 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 710421003411 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710421003412 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710421003413 active site residue [active] 710421003414 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710421003415 active site residue [active] 710421003416 amino acid transporter; Region: 2A0306; TIGR00909 710421003417 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710421003418 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 710421003419 active site 710421003420 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 710421003421 N-carbamolyputrescine amidase; Region: PLN02747 710421003422 active site 710421003423 catalytic triad [active] 710421003424 dimer interface [polypeptide binding]; other site 710421003425 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710421003426 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710421003427 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 710421003428 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710421003429 Putative esterase; Region: Esterase; pfam00756 710421003430 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 710421003431 homodimer interface [polypeptide binding]; other site 710421003432 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 710421003433 active site pocket [active] 710421003434 MASE1; Region: MASE1; cl17823 710421003435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710421003436 putative active site [active] 710421003437 heme pocket [chemical binding]; other site 710421003438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421003439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421003440 metal binding site [ion binding]; metal-binding site 710421003441 active site 710421003442 I-site; other site 710421003443 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 710421003444 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421003445 Phospholipid methyltransferase; Region: PEMT; cl17370 710421003446 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 710421003447 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 710421003448 malonyl-CoA binding site [chemical binding]; other site 710421003449 dimer interface [polypeptide binding]; other site 710421003450 active site 710421003451 product binding site; other site 710421003452 MMPL family; Region: MMPL; pfam03176 710421003453 MMPL family; Region: MMPL; pfam03176 710421003454 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 710421003455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421003456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421003457 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 710421003458 DNA binding residues [nucleotide binding] 710421003459 dimerization interface [polypeptide binding]; other site 710421003460 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 710421003461 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 710421003462 AAA domain; Region: AAA_30; pfam13604 710421003463 Family description; Region: UvrD_C_2; pfam13538 710421003464 Uncharacterized conserved protein [Function unknown]; Region: COG1432 710421003465 NYN domain; Region: NYN; pfam01936 710421003466 putative metal binding site [ion binding]; other site 710421003467 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 710421003468 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 710421003469 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710421003470 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 710421003471 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 710421003472 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 710421003473 HD domain; Region: HD_4; pfam13328 710421003474 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710421003475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710421003476 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710421003477 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 710421003478 oligomer interface [polypeptide binding]; other site 710421003479 metal binding site [ion binding]; metal-binding site 710421003480 metal binding site [ion binding]; metal-binding site 710421003481 putative Cl binding site [ion binding]; other site 710421003482 aspartate ring; other site 710421003483 basic sphincter; other site 710421003484 hydrophobic gate; other site 710421003485 periplasmic entrance; other site 710421003486 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421003487 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421003488 substrate binding site [chemical binding]; other site 710421003489 oxyanion hole (OAH) forming residues; other site 710421003490 trimer interface [polypeptide binding]; other site 710421003491 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 710421003492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710421003493 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 710421003494 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710421003495 active site 710421003496 catalytic site [active] 710421003497 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 710421003498 active site 710421003499 catalytic site [active] 710421003500 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710421003501 active site 710421003502 catalytic site [active] 710421003503 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 710421003504 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 710421003505 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 710421003506 putative homodimer interface [polypeptide binding]; other site 710421003507 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 710421003508 heterodimer interface [polypeptide binding]; other site 710421003509 homodimer interface [polypeptide binding]; other site 710421003510 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 710421003511 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 710421003512 23S rRNA interface [nucleotide binding]; other site 710421003513 L7/L12 interface [polypeptide binding]; other site 710421003514 putative thiostrepton binding site; other site 710421003515 L25 interface [polypeptide binding]; other site 710421003516 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 710421003517 mRNA/rRNA interface [nucleotide binding]; other site 710421003518 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710421003519 MULE transposase domain; Region: MULE; pfam10551 710421003520 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710421003521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421003522 S-adenosylmethionine binding site [chemical binding]; other site 710421003523 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421003524 TAP-like protein; Region: Abhydrolase_4; pfam08386 710421003525 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710421003526 ABC1 family; Region: ABC1; pfam03109 710421003527 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 710421003528 active site 710421003529 ATP binding site [chemical binding]; other site 710421003530 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 710421003531 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421003532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421003533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003534 Protein of unknown function (DUF664); Region: DUF664; pfam04978 710421003535 DinB superfamily; Region: DinB_2; pfam12867 710421003536 DinB superfamily; Region: DinB_2; pfam12867 710421003537 HTH domain; Region: HTH_11; pfam08279 710421003538 WYL domain; Region: WYL; pfam13280 710421003539 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 710421003540 active site 710421003541 catalytic site [active] 710421003542 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 710421003543 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 710421003544 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 710421003545 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710421003546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 710421003547 nucleotide binding site [chemical binding]; other site 710421003548 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 710421003549 23S rRNA interface [nucleotide binding]; other site 710421003550 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 710421003551 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 710421003552 L11 interface [polypeptide binding]; other site 710421003553 putative EF-Tu interaction site [polypeptide binding]; other site 710421003554 putative EF-G interaction site [polypeptide binding]; other site 710421003555 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 710421003556 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 710421003557 Walker A/P-loop; other site 710421003558 ATP binding site [chemical binding]; other site 710421003559 Q-loop/lid; other site 710421003560 ABC transporter signature motif; other site 710421003561 Walker B; other site 710421003562 D-loop; other site 710421003563 H-loop/switch region; other site 710421003564 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710421003565 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 710421003566 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 710421003567 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 710421003568 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710421003569 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710421003570 RPB10 interaction site [polypeptide binding]; other site 710421003571 RPB1 interaction site [polypeptide binding]; other site 710421003572 RPB11 interaction site [polypeptide binding]; other site 710421003573 RPB3 interaction site [polypeptide binding]; other site 710421003574 RPB12 interaction site [polypeptide binding]; other site 710421003575 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 710421003576 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 710421003577 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 710421003578 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 710421003579 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 710421003580 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 710421003581 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 710421003582 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 710421003583 G-loop; other site 710421003584 DNA binding site [nucleotide binding] 710421003585 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710421003586 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421003587 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710421003588 endonuclease IV; Provisional; Region: PRK01060 710421003589 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 710421003590 AP (apurinic/apyrimidinic) site pocket; other site 710421003591 DNA interaction; other site 710421003592 Metal-binding active site; metal-binding site 710421003593 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 710421003594 active site 710421003595 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 710421003596 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 710421003597 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 710421003598 putative active site [active] 710421003599 putative substrate binding site [chemical binding]; other site 710421003600 putative cosubstrate binding site; other site 710421003601 catalytic site [active] 710421003602 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 710421003603 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421003604 active site 710421003605 enoyl-CoA hydratase; Provisional; Region: PRK12478 710421003606 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421003607 substrate binding site [chemical binding]; other site 710421003608 oxyanion hole (OAH) forming residues; other site 710421003609 trimer interface [polypeptide binding]; other site 710421003610 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 710421003611 PaaX-like protein; Region: PaaX; pfam07848 710421003612 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 710421003613 enoyl-CoA hydratase; Provisional; Region: PRK06688 710421003614 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421003615 substrate binding site [chemical binding]; other site 710421003616 oxyanion hole (OAH) forming residues; other site 710421003617 trimer interface [polypeptide binding]; other site 710421003618 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710421003619 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 710421003620 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710421003621 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710421003622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421003623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003624 WHG domain; Region: WHG; pfam13305 710421003625 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 710421003626 S17 interaction site [polypeptide binding]; other site 710421003627 S8 interaction site; other site 710421003628 16S rRNA interaction site [nucleotide binding]; other site 710421003629 streptomycin interaction site [chemical binding]; other site 710421003630 23S rRNA interaction site [nucleotide binding]; other site 710421003631 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 710421003632 30S ribosomal protein S7; Validated; Region: PRK05302 710421003633 elongation factor G; Reviewed; Region: PRK00007 710421003634 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 710421003635 G1 box; other site 710421003636 putative GEF interaction site [polypeptide binding]; other site 710421003637 GTP/Mg2+ binding site [chemical binding]; other site 710421003638 Switch I region; other site 710421003639 G2 box; other site 710421003640 G3 box; other site 710421003641 Switch II region; other site 710421003642 G4 box; other site 710421003643 G5 box; other site 710421003644 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710421003645 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710421003646 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710421003647 elongation factor Tu; Reviewed; Region: PRK00049 710421003648 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 710421003649 G1 box; other site 710421003650 GEF interaction site [polypeptide binding]; other site 710421003651 GTP/Mg2+ binding site [chemical binding]; other site 710421003652 Switch I region; other site 710421003653 G2 box; other site 710421003654 G3 box; other site 710421003655 Switch II region; other site 710421003656 G4 box; other site 710421003657 G5 box; other site 710421003658 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710421003659 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 710421003660 Antibiotic Binding Site [chemical binding]; other site 710421003661 Cutinase; Region: Cutinase; pfam01083 710421003662 Short C-terminal domain; Region: SHOCT; pfam09851 710421003663 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421003664 classical (c) SDRs; Region: SDR_c; cd05233 710421003665 NAD(P) binding site [chemical binding]; other site 710421003666 active site 710421003667 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 710421003668 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421003669 inhibitor-cofactor binding pocket; inhibition site 710421003670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421003671 catalytic residue [active] 710421003672 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 710421003673 Amidinotransferase; Region: Amidinotransf; pfam02274 710421003674 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710421003675 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421003676 putative DNA binding site [nucleotide binding]; other site 710421003677 putative Zn2+ binding site [ion binding]; other site 710421003678 AsnC family; Region: AsnC_trans_reg; pfam01037 710421003679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710421003680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421003681 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421003682 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421003683 active site 710421003684 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710421003685 putative dimer interface [polypeptide binding]; other site 710421003686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421003687 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710421003688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421003689 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710421003690 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421003691 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710421003692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421003693 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710421003694 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710421003695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003696 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 710421003697 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 710421003698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421003699 FeS/SAM binding site; other site 710421003700 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 710421003701 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 710421003702 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710421003703 phosphate binding site [ion binding]; other site 710421003704 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 710421003705 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 710421003706 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710421003707 Probable Catalytic site; other site 710421003708 metal-binding site 710421003709 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 710421003710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421003711 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710421003712 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 710421003713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421003714 putative substrate translocation pore; other site 710421003715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421003716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421003717 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421003718 Cytochrome P450; Region: p450; cl12078 710421003719 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421003720 Cytochrome P450; Region: p450; cl12078 710421003721 Carboxylesterase family; Region: COesterase; pfam00135 710421003722 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421003723 substrate binding pocket [chemical binding]; other site 710421003724 catalytic triad [active] 710421003725 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 710421003726 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 710421003727 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 710421003728 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 710421003729 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 710421003730 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 710421003731 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 710421003732 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 710421003733 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 710421003734 putative translocon binding site; other site 710421003735 protein-rRNA interface [nucleotide binding]; other site 710421003736 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 710421003737 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 710421003738 G-X-X-G motif; other site 710421003739 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 710421003740 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 710421003741 23S rRNA interface [nucleotide binding]; other site 710421003742 5S rRNA interface [nucleotide binding]; other site 710421003743 putative antibiotic binding site [chemical binding]; other site 710421003744 L25 interface [polypeptide binding]; other site 710421003745 L27 interface [polypeptide binding]; other site 710421003746 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 710421003747 putative translocon interaction site; other site 710421003748 signal recognition particle (SRP54) interaction site; other site 710421003749 L23 interface [polypeptide binding]; other site 710421003750 trigger factor interaction site; other site 710421003751 23S rRNA interface [nucleotide binding]; other site 710421003752 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 710421003753 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710421003754 Sulfatase; Region: Sulfatase; pfam00884 710421003755 Uncharacterized conserved protein [Function unknown]; Region: COG1262 710421003756 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710421003757 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 710421003758 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 710421003759 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 710421003760 RNA binding site [nucleotide binding]; other site 710421003761 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 710421003762 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 710421003763 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 710421003764 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 710421003765 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 710421003766 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 710421003767 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710421003768 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710421003769 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 710421003770 5S rRNA interface [nucleotide binding]; other site 710421003771 L27 interface [polypeptide binding]; other site 710421003772 23S rRNA interface [nucleotide binding]; other site 710421003773 L5 interface [polypeptide binding]; other site 710421003774 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 710421003775 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 710421003776 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 710421003777 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 710421003778 23S rRNA binding site [nucleotide binding]; other site 710421003779 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 710421003780 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710421003781 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 710421003782 tandem repeat interface [polypeptide binding]; other site 710421003783 oligomer interface [polypeptide binding]; other site 710421003784 active site residues [active] 710421003785 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 710421003786 tandem repeat interface [polypeptide binding]; other site 710421003787 oligomer interface [polypeptide binding]; other site 710421003788 active site residues [active] 710421003789 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421003790 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421003791 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421003792 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421003793 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421003794 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421003795 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421003796 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421003797 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 710421003798 SecY translocase; Region: SecY; pfam00344 710421003799 adenylate kinase; Reviewed; Region: adk; PRK00279 710421003800 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710421003801 AMP-binding site [chemical binding]; other site 710421003802 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710421003803 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710421003804 active site 710421003805 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 710421003806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421003807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421003808 DNA binding residues [nucleotide binding] 710421003809 Putative zinc-finger; Region: zf-HC2; pfam13490 710421003810 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 710421003811 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710421003812 PYR/PP interface [polypeptide binding]; other site 710421003813 dimer interface [polypeptide binding]; other site 710421003814 TPP binding site [chemical binding]; other site 710421003815 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710421003816 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 710421003817 TPP-binding site [chemical binding]; other site 710421003818 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 710421003819 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710421003820 active site 710421003821 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 710421003822 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421003823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421003824 homodimer interface [polypeptide binding]; other site 710421003825 catalytic residue [active] 710421003826 MarR family; Region: MarR; pfam01047 710421003827 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710421003828 GAF domain; Region: GAF_2; pfam13185 710421003829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421003830 Histidine kinase; Region: HisKA_3; pfam07730 710421003831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421003832 ATP binding site [chemical binding]; other site 710421003833 Mg2+ binding site [ion binding]; other site 710421003834 G-X-G motif; other site 710421003835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421003836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421003837 active site 710421003838 phosphorylation site [posttranslational modification] 710421003839 intermolecular recognition site; other site 710421003840 dimerization interface [polypeptide binding]; other site 710421003841 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421003842 DNA binding residues [nucleotide binding] 710421003843 dimerization interface [polypeptide binding]; other site 710421003844 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 710421003845 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421003846 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 710421003847 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421003848 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 710421003849 substrate binding pocket [chemical binding]; other site 710421003850 FAD binding site [chemical binding]; other site 710421003851 catalytic base [active] 710421003852 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710421003853 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710421003854 tetrameric interface [polypeptide binding]; other site 710421003855 NAD binding site [chemical binding]; other site 710421003856 catalytic residues [active] 710421003857 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421003858 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421003859 active site 710421003860 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 710421003861 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 710421003862 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 710421003863 NAD binding site [chemical binding]; other site 710421003864 substrate binding site [chemical binding]; other site 710421003865 homodimer interface [polypeptide binding]; other site 710421003866 active site 710421003867 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710421003868 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710421003869 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710421003870 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710421003871 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710421003872 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710421003873 ligand binding site [chemical binding]; other site 710421003874 flexible hinge region; other site 710421003875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421003876 ATP binding site [chemical binding]; other site 710421003877 Mg2+ binding site [ion binding]; other site 710421003878 G-X-G motif; other site 710421003879 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710421003880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421003881 active site 710421003882 phosphorylation site [posttranslational modification] 710421003883 intermolecular recognition site; other site 710421003884 dimerization interface [polypeptide binding]; other site 710421003885 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710421003886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421003887 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003888 Ligand Binding Site [chemical binding]; other site 710421003889 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003890 Ligand Binding Site [chemical binding]; other site 710421003891 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710421003892 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710421003893 putative dimer interface [polypeptide binding]; other site 710421003894 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 710421003895 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06406 710421003896 ATP cone domain; Region: ATP-cone; pfam03477 710421003897 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 710421003898 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 710421003899 active site 710421003900 dimer interface [polypeptide binding]; other site 710421003901 effector binding site; other site 710421003902 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 710421003903 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 710421003904 30S subunit binding site; other site 710421003905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 710421003906 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710421003907 FOG: CBS domain [General function prediction only]; Region: COG0517 710421003908 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 710421003909 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003910 Ligand Binding Site [chemical binding]; other site 710421003911 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003912 Ligand Binding Site [chemical binding]; other site 710421003913 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421003914 acetyl-CoA synthetase; Provisional; Region: PRK04319 710421003915 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 710421003916 active site 710421003917 acyl-activating enzyme (AAE) consensus motif; other site 710421003918 putative CoA binding site [chemical binding]; other site 710421003919 AMP binding site [chemical binding]; other site 710421003920 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 710421003921 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710421003922 tetramer interface [polypeptide binding]; other site 710421003923 TPP-binding site [chemical binding]; other site 710421003924 heterodimer interface [polypeptide binding]; other site 710421003925 phosphorylation loop region [posttranslational modification] 710421003926 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710421003927 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710421003928 alpha subunit interface [polypeptide binding]; other site 710421003929 TPP binding site [chemical binding]; other site 710421003930 heterodimer interface [polypeptide binding]; other site 710421003931 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710421003932 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 710421003933 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710421003934 E3 interaction surface; other site 710421003935 lipoyl attachment site [posttranslational modification]; other site 710421003936 e3 binding domain; Region: E3_binding; pfam02817 710421003937 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710421003938 Phosphopantetheine attachment site; Region: PP-binding; cl09936 710421003939 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 710421003940 active site 710421003941 Peptidase family M50; Region: Peptidase_M50; pfam02163 710421003942 putative substrate binding region [chemical binding]; other site 710421003943 FOG: CBS domain [General function prediction only]; Region: COG0517 710421003944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 710421003945 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 710421003946 ANTAR domain; Region: ANTAR; cl04297 710421003947 Domain of unknown function DUF302; Region: DUF302; cl01364 710421003948 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 710421003949 putative homotetramer interface [polypeptide binding]; other site 710421003950 putative homodimer interface [polypeptide binding]; other site 710421003951 putative allosteric switch controlling residues; other site 710421003952 putative metal binding site [ion binding]; other site 710421003953 putative homodimer-homodimer interface [polypeptide binding]; other site 710421003954 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710421003955 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421003956 active site residue [active] 710421003957 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710421003958 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421003959 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421003960 active site residue [active] 710421003961 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003962 Ligand Binding Site [chemical binding]; other site 710421003963 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003964 Ligand Binding Site [chemical binding]; other site 710421003965 RNA binding site [nucleotide binding]; other site 710421003966 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710421003967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003968 Ligand Binding Site [chemical binding]; other site 710421003969 CHASE3 domain; Region: CHASE3; pfam05227 710421003970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421003971 dimerization interface [polypeptide binding]; other site 710421003972 Histidine kinase; Region: HisKA_3; pfam07730 710421003973 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710421003974 ATP binding site [chemical binding]; other site 710421003975 Mg2+ binding site [ion binding]; other site 710421003976 G-X-G motif; other site 710421003977 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710421003978 Domain of unknown function DUF21; Region: DUF21; pfam01595 710421003979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710421003980 Transporter associated domain; Region: CorC_HlyC; smart01091 710421003981 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 710421003982 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 710421003983 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710421003984 TrkA-N domain; Region: TrkA_N; pfam02254 710421003985 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 710421003986 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 710421003987 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421003988 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 710421003989 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421003990 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710421003991 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003992 Ligand Binding Site [chemical binding]; other site 710421003993 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421003994 Ligand Binding Site [chemical binding]; other site 710421003995 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421003996 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421003997 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421003998 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 710421003999 rRNA binding site [nucleotide binding]; other site 710421004000 predicted 30S ribosome binding site; other site 710421004001 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 710421004002 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 710421004003 30S ribosomal protein S13; Region: bact_S13; TIGR03631 710421004004 30S ribosomal protein S11; Validated; Region: PRK05309 710421004005 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 710421004006 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 710421004007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710421004008 RNA binding surface [nucleotide binding]; other site 710421004009 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 710421004010 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 710421004011 alphaNTD - beta interaction site [polypeptide binding]; other site 710421004012 alphaNTD homodimer interface [polypeptide binding]; other site 710421004013 alphaNTD - beta' interaction site [polypeptide binding]; other site 710421004014 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 710421004015 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 710421004016 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 710421004017 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 710421004018 dimerization interface 3.5A [polypeptide binding]; other site 710421004019 active site 710421004020 Cutinase; Region: Cutinase; pfam01083 710421004021 Cutinase; Region: Cutinase; pfam01083 710421004022 Cutinase; Region: Cutinase; pfam01083 710421004023 EamA-like transporter family; Region: EamA; pfam00892 710421004024 EamA-like transporter family; Region: EamA; pfam00892 710421004025 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 710421004026 CGNR zinc finger; Region: zf-CGNR; pfam11706 710421004027 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 710421004028 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710421004029 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 710421004030 active site 710421004031 catalytic residues [active] 710421004032 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 710421004033 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 710421004034 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421004035 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 710421004036 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421004037 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421004038 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 710421004039 Proteins of 100 residues with WXG; Region: WXG100; cl02005 710421004040 Proteins of 100 residues with WXG; Region: WXG100; cl02005 710421004041 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 710421004042 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 710421004043 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421004044 NAD(P) binding site [chemical binding]; other site 710421004045 catalytic residues [active] 710421004046 ethanolamine permease; Region: 2A0305; TIGR00908 710421004047 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 710421004048 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 710421004049 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 710421004050 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 710421004051 23S rRNA interface [nucleotide binding]; other site 710421004052 L3 interface [polypeptide binding]; other site 710421004053 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 710421004054 SPW repeat; Region: SPW; pfam03779 710421004055 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 710421004056 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 710421004057 active site 710421004058 substrate binding site [chemical binding]; other site 710421004059 metal binding site [ion binding]; metal-binding site 710421004060 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421004061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421004062 active site 710421004063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004065 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 710421004066 putative FMN binding site [chemical binding]; other site 710421004067 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710421004068 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710421004069 putative NAD(P) binding site [chemical binding]; other site 710421004070 short chain dehydrogenase; Provisional; Region: PRK06523 710421004071 classical (c) SDRs; Region: SDR_c; cd05233 710421004072 NAD(P) binding site [chemical binding]; other site 710421004073 active site 710421004074 AAA ATPase domain; Region: AAA_16; pfam13191 710421004075 Walker A motif; other site 710421004076 ATP binding site [chemical binding]; other site 710421004077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421004078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421004079 DNA binding residues [nucleotide binding] 710421004080 dimerization interface [polypeptide binding]; other site 710421004081 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710421004082 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421004083 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710421004084 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421004085 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421004086 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 710421004087 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 710421004088 glutaminase active site [active] 710421004089 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710421004090 dimer interface [polypeptide binding]; other site 710421004091 active site 710421004092 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710421004093 dimer interface [polypeptide binding]; other site 710421004094 active site 710421004095 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421004096 anti sigma factor interaction site; other site 710421004097 regulatory phosphorylation site [posttranslational modification]; other site 710421004098 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710421004099 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421004100 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421004101 active site 710421004102 SnoaL-like domain; Region: SnoaL_3; pfam13474 710421004103 Uncharacterized conserved protein [Function unknown]; Region: COG0062 710421004104 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 710421004105 putative substrate binding site [chemical binding]; other site 710421004106 putative ATP binding site [chemical binding]; other site 710421004107 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 710421004108 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 710421004109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421004110 catalytic residue [active] 710421004111 alanine racemase; Reviewed; Region: alr; PRK00053 710421004112 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 710421004113 active site 710421004114 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710421004115 dimer interface [polypeptide binding]; other site 710421004116 substrate binding site [chemical binding]; other site 710421004117 catalytic residues [active] 710421004118 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421004119 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421004120 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710421004121 TAP-like protein; Region: Abhydrolase_4; pfam08386 710421004122 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 710421004123 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 710421004124 Glycoprotease family; Region: Peptidase_M22; pfam00814 710421004125 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 710421004126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421004127 Coenzyme A binding pocket [chemical binding]; other site 710421004128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710421004129 UGMP family protein; Validated; Region: PRK09604 710421004130 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710421004131 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421004132 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421004133 active site 710421004134 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 710421004135 oligomerisation interface [polypeptide binding]; other site 710421004136 mobile loop; other site 710421004137 roof hairpin; other site 710421004138 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710421004139 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710421004140 ring oligomerisation interface [polypeptide binding]; other site 710421004141 ATP/Mg binding site [chemical binding]; other site 710421004142 stacking interactions; other site 710421004143 hinge regions; other site 710421004144 Cupin domain; Region: Cupin_2; pfam07883 710421004145 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710421004146 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 710421004147 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710421004148 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 710421004149 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 710421004150 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 710421004151 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 710421004152 Putative esterase; Region: Esterase; pfam00756 710421004153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421004154 putative substrate translocation pore; other site 710421004155 Transcription factor WhiB; Region: Whib; pfam02467 710421004156 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 710421004157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421004158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421004159 DNA binding residues [nucleotide binding] 710421004160 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 710421004161 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710421004162 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 710421004163 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710421004164 active site 710421004165 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 710421004166 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710421004167 phosphate binding site [ion binding]; other site 710421004168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004170 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710421004171 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710421004172 GMP synthase; Reviewed; Region: guaA; PRK00074 710421004173 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 710421004174 AMP/PPi binding site [chemical binding]; other site 710421004175 candidate oxyanion hole; other site 710421004176 catalytic triad [active] 710421004177 potential glutamine specificity residues [chemical binding]; other site 710421004178 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 710421004179 ATP Binding subdomain [chemical binding]; other site 710421004180 Ligand Binding sites [chemical binding]; other site 710421004181 Dimerization subdomain; other site 710421004182 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 710421004183 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710421004184 DNA binding residues [nucleotide binding] 710421004185 putative dimer interface [polypeptide binding]; other site 710421004186 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421004187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421004188 classical (c) SDRs; Region: SDR_c; cd05233 710421004189 short chain dehydrogenase; Provisional; Region: PRK05650 710421004190 NAD(P) binding site [chemical binding]; other site 710421004191 active site 710421004192 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710421004193 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 710421004194 DNA Polymerase Y-family; Region: PolY_like; cd03468 710421004195 active site 710421004196 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 710421004197 DNA binding site [nucleotide binding] 710421004198 MarR family; Region: MarR_2; cl17246 710421004199 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710421004200 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 710421004201 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 710421004202 active site 710421004203 short chain dehydrogenase; Provisional; Region: PRK07201 710421004204 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 710421004205 putative NAD(P) binding site [chemical binding]; other site 710421004206 active site 710421004207 putative substrate binding site [chemical binding]; other site 710421004208 classical (c) SDRs; Region: SDR_c; cd05233 710421004209 NAD(P) binding site [chemical binding]; other site 710421004210 active site 710421004211 enoyl-CoA hydratase; Region: PLN02864 710421004212 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421004213 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 710421004214 dimer interaction site [polypeptide binding]; other site 710421004215 substrate-binding tunnel; other site 710421004216 active site 710421004217 catalytic site [active] 710421004218 substrate binding site [chemical binding]; other site 710421004219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421004220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421004221 metal binding site [ion binding]; metal-binding site 710421004222 active site 710421004223 I-site; other site 710421004224 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 710421004225 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 710421004226 active site 710421004227 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710421004228 generic binding surface II; other site 710421004229 generic binding surface I; other site 710421004230 SOUL heme-binding protein; Region: SOUL; pfam04832 710421004231 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710421004232 FMN binding site [chemical binding]; other site 710421004233 dimer interface [polypeptide binding]; other site 710421004234 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 710421004235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421004236 S-adenosylmethionine binding site [chemical binding]; other site 710421004237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421004238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421004239 ATP binding site [chemical binding]; other site 710421004240 Mg2+ binding site [ion binding]; other site 710421004241 G-X-G motif; other site 710421004242 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 710421004243 Protein of unknown function (DUF742); Region: DUF742; pfam05331 710421004244 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 710421004245 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 710421004246 G1 box; other site 710421004247 GTP/Mg2+ binding site [chemical binding]; other site 710421004248 G2 box; other site 710421004249 Switch I region; other site 710421004250 G3 box; other site 710421004251 Switch II region; other site 710421004252 G4 box; other site 710421004253 G5 box; other site 710421004254 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 710421004255 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710421004256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 710421004257 Predicted transcriptional regulator [Transcription]; Region: COG1959 710421004258 Transcriptional regulator; Region: Rrf2; cl17282 710421004259 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 710421004260 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 710421004261 heme-binding site [chemical binding]; other site 710421004262 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 710421004263 FAD binding pocket [chemical binding]; other site 710421004264 FAD binding motif [chemical binding]; other site 710421004265 phosphate binding motif [ion binding]; other site 710421004266 beta-alpha-beta structure motif; other site 710421004267 NAD binding pocket [chemical binding]; other site 710421004268 Heme binding pocket [chemical binding]; other site 710421004269 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710421004270 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421004271 phosphopeptide binding site; other site 710421004272 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421004273 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710421004274 phosphopeptide binding site; other site 710421004275 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 710421004276 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710421004277 Walker A/P-loop; other site 710421004278 ATP binding site [chemical binding]; other site 710421004279 Q-loop/lid; other site 710421004280 ABC transporter signature motif; other site 710421004281 Walker B; other site 710421004282 D-loop; other site 710421004283 H-loop/switch region; other site 710421004284 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421004285 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710421004286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004288 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710421004289 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 710421004290 active site 710421004291 FMN binding site [chemical binding]; other site 710421004292 substrate binding site [chemical binding]; other site 710421004293 putative catalytic residue [active] 710421004294 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 710421004295 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 710421004296 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 710421004297 homodimer interface [polypeptide binding]; other site 710421004298 NADP binding site [chemical binding]; other site 710421004299 substrate binding site [chemical binding]; other site 710421004300 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 710421004301 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421004302 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421004303 active site 710421004304 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710421004305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004306 hypothetical protein; Provisional; Region: PRK06834 710421004307 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421004308 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421004309 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421004310 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532 710421004311 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710421004312 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710421004313 FAD binding pocket [chemical binding]; other site 710421004314 FAD binding motif [chemical binding]; other site 710421004315 phosphate binding motif [ion binding]; other site 710421004316 beta-alpha-beta structure motif; other site 710421004317 NAD binding pocket [chemical binding]; other site 710421004318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421004319 catalytic loop [active] 710421004320 iron binding site [ion binding]; other site 710421004321 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710421004322 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710421004323 putative di-iron ligands [ion binding]; other site 710421004324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421004325 S-adenosylmethionine binding site [chemical binding]; other site 710421004326 ubiquinone biosynthesis methyltransferase; Region: PLN02232 710421004327 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 710421004328 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 710421004329 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 710421004330 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710421004331 homodimer interface [polypeptide binding]; other site 710421004332 substrate-cofactor binding pocket; other site 710421004333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421004334 catalytic residue [active] 710421004335 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 710421004336 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710421004337 active site 710421004338 FMN binding site [chemical binding]; other site 710421004339 substrate binding site [chemical binding]; other site 710421004340 3Fe-4S cluster binding site [ion binding]; other site 710421004341 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421004342 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710421004343 putative catalytic site [active] 710421004344 putative metal binding site [ion binding]; other site 710421004345 putative phosphate binding site [ion binding]; other site 710421004346 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 710421004347 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 710421004348 active site 710421004349 HIGH motif; other site 710421004350 dimer interface [polypeptide binding]; other site 710421004351 KMSKS motif; other site 710421004352 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 710421004353 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710421004354 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710421004355 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710421004356 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710421004357 putative active site [active] 710421004358 putative metal binding site [ion binding]; other site 710421004359 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 710421004360 Strictosidine synthase; Region: Str_synth; pfam03088 710421004361 hypothetical protein; Provisional; Region: PRK06541 710421004362 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421004363 inhibitor-cofactor binding pocket; inhibition site 710421004364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421004365 catalytic residue [active] 710421004366 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710421004367 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 710421004368 AsnC family; Region: AsnC_trans_reg; pfam01037 710421004369 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 710421004370 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710421004371 NAD(P) binding site [chemical binding]; other site 710421004372 catalytic residues [active] 710421004373 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421004374 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 710421004375 NAD(P) binding site [chemical binding]; other site 710421004376 catalytic residues [active] 710421004377 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 710421004378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421004379 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710421004380 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421004381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421004382 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710421004383 NAD(P) binding site [chemical binding]; other site 710421004384 active site 710421004385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421004388 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710421004389 NAD(P) binding site [chemical binding]; other site 710421004390 active site 710421004391 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 710421004392 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710421004393 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421004394 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710421004395 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710421004396 substrate binding pocket [chemical binding]; other site 710421004397 chain length determination region; other site 710421004398 substrate-Mg2+ binding site; other site 710421004399 catalytic residues [active] 710421004400 aspartate-rich region 1; other site 710421004401 active site lid residues [active] 710421004402 aspartate-rich region 2; other site 710421004403 phytoene desaturase; Region: crtI_fam; TIGR02734 710421004404 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 710421004405 active site lid residues [active] 710421004406 substrate binding pocket [chemical binding]; other site 710421004407 catalytic residues [active] 710421004408 substrate-Mg2+ binding site; other site 710421004409 aspartate-rich region 1; other site 710421004410 aspartate-rich region 2; other site 710421004411 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 710421004412 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 710421004413 Uncharacterized conserved protein [Function unknown]; Region: COG3349 710421004414 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 710421004415 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 710421004416 MgtE intracellular N domain; Region: MgtE_N; cl15244 710421004417 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 710421004418 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710421004419 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710421004420 active site 710421004421 catalytic site [active] 710421004422 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 710421004423 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 710421004424 putative catalytic cysteine [active] 710421004425 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710421004426 active site 710421004427 NAD binding site [chemical binding]; other site 710421004428 metal binding site [ion binding]; metal-binding site 710421004429 flavodoxin; Provisional; Region: PRK06242 710421004430 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710421004431 iron-sulfur cluster [ion binding]; other site 710421004432 [2Fe-2S] cluster binding site [ion binding]; other site 710421004433 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 710421004434 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 710421004435 active site 710421004436 metal binding site [ion binding]; metal-binding site 710421004437 nudix motif; other site 710421004438 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710421004439 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004440 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004441 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710421004442 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004443 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710421004444 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710421004445 structural tetrad; other site 710421004446 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004447 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004448 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004449 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004450 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710421004451 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004452 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004453 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 710421004454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710421004455 ATP binding site [chemical binding]; other site 710421004456 putative Mg++ binding site [ion binding]; other site 710421004457 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 710421004458 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 710421004459 CGNR zinc finger; Region: zf-CGNR; pfam11706 710421004460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421004461 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421004462 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 710421004463 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 710421004464 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 710421004465 L-aspartate oxidase; Provisional; Region: PRK06175 710421004466 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710421004467 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 710421004468 putative Iron-sulfur protein interface [polypeptide binding]; other site 710421004469 putative proximal heme binding site [chemical binding]; other site 710421004470 putative SdhC-like subunit interface [polypeptide binding]; other site 710421004471 putative distal heme binding site [chemical binding]; other site 710421004472 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 710421004473 putative Iron-sulfur protein interface [polypeptide binding]; other site 710421004474 putative proximal heme binding site [chemical binding]; other site 710421004475 putative SdhD-like interface [polypeptide binding]; other site 710421004476 putative distal heme binding site [chemical binding]; other site 710421004477 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 710421004478 active site 710421004479 catalytic motif [active] 710421004480 Zn binding site [ion binding]; other site 710421004481 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 710421004482 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710421004483 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710421004484 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 710421004485 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 710421004486 adenosine deaminase; Provisional; Region: PRK09358 710421004487 active site 710421004488 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421004489 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421004490 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710421004491 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710421004492 acyl-activating enzyme (AAE) consensus motif; other site 710421004493 putative AMP binding site [chemical binding]; other site 710421004494 putative active site [active] 710421004495 putative CoA binding site [chemical binding]; other site 710421004496 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421004497 Permease; Region: Permease; pfam02405 710421004498 aromatic amino acid aminotransferase; Validated; Region: PRK07309 710421004499 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710421004500 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421004501 putative acyl-acceptor binding pocket; other site 710421004502 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421004503 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421004504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421004505 active site 710421004506 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 710421004507 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 710421004508 active site 710421004509 substrate binding site [chemical binding]; other site 710421004510 metal binding site [ion binding]; metal-binding site 710421004511 MarR family; Region: MarR_2; pfam12802 710421004512 Putative ammonia monooxygenase; Region: AmoA; pfam05145 710421004513 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 710421004514 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 710421004515 purine nucleoside phosphorylase; Provisional; Region: PRK08202 710421004516 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 710421004517 amidohydrolase; Region: amidohydrolases; TIGR01891 710421004518 metal binding site [ion binding]; metal-binding site 710421004519 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 710421004520 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 710421004521 metal binding site [ion binding]; metal-binding site 710421004522 putative dimer interface [polypeptide binding]; other site 710421004523 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710421004524 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 710421004525 putative active site pocket [active] 710421004526 dimerization interface [polypeptide binding]; other site 710421004527 putative catalytic residue [active] 710421004528 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 710421004529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421004530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421004531 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421004532 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 710421004533 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 710421004534 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 710421004535 probable active site [active] 710421004536 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710421004537 classical (c) SDRs; Region: SDR_c; cd05233 710421004538 NAD(P) binding site [chemical binding]; other site 710421004539 active site 710421004540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004542 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421004543 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421004544 [2Fe-2S] cluster binding site [ion binding]; other site 710421004545 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 710421004546 putative alpha subunit interface [polypeptide binding]; other site 710421004547 putative active site [active] 710421004548 putative substrate binding site [chemical binding]; other site 710421004549 Fe binding site [ion binding]; other site 710421004550 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421004551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421004552 substrate binding site [chemical binding]; other site 710421004553 oxyanion hole (OAH) forming residues; other site 710421004554 trimer interface [polypeptide binding]; other site 710421004555 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 710421004556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004557 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710421004558 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 710421004559 FAD binding pocket [chemical binding]; other site 710421004560 FAD binding motif [chemical binding]; other site 710421004561 phosphate binding motif [ion binding]; other site 710421004562 beta-alpha-beta structure motif; other site 710421004563 NAD binding pocket [chemical binding]; other site 710421004564 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421004565 catalytic loop [active] 710421004566 iron binding site [ion binding]; other site 710421004567 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710421004568 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710421004569 putative di-iron ligands [ion binding]; other site 710421004570 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710421004571 Sulfatase; Region: Sulfatase; pfam00884 710421004572 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710421004573 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710421004574 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 710421004575 putative DNA binding site [nucleotide binding]; other site 710421004576 catalytic residue [active] 710421004577 putative H2TH interface [polypeptide binding]; other site 710421004578 putative catalytic residues [active] 710421004579 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710421004580 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710421004581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421004582 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 710421004583 ATP binding site [chemical binding]; other site 710421004584 putative Mg++ binding site [ion binding]; other site 710421004585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421004586 nucleotide binding region [chemical binding]; other site 710421004587 ATP-binding site [chemical binding]; other site 710421004588 DEAD/H associated; Region: DEAD_assoc; pfam08494 710421004589 AAA ATPase domain; Region: AAA_16; pfam13191 710421004590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421004591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421004592 DNA binding residues [nucleotide binding] 710421004593 dimerization interface [polypeptide binding]; other site 710421004594 SnoaL-like domain; Region: SnoaL_3; pfam13474 710421004595 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 710421004596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004598 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710421004599 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 710421004600 ligand binding site [chemical binding]; other site 710421004601 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 710421004602 PAS fold; Region: PAS_4; pfam08448 710421004603 classical (c) SDRs; Region: SDR_c; cd05233 710421004604 short chain dehydrogenase; Provisional; Region: PRK05650 710421004605 NAD(P) binding site [chemical binding]; other site 710421004606 active site 710421004607 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 710421004608 aldehyde dehydrogenase family 7 member; Region: PLN02315 710421004609 tetrameric interface [polypeptide binding]; other site 710421004610 NAD binding site [chemical binding]; other site 710421004611 catalytic residues [active] 710421004612 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 710421004613 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 710421004614 AsnC family; Region: AsnC_trans_reg; pfam01037 710421004615 L-lysine aminotransferase; Provisional; Region: PRK08297 710421004616 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421004617 inhibitor-cofactor binding pocket; inhibition site 710421004618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421004619 catalytic residue [active] 710421004620 Restriction endonuclease; Region: Mrr_cat; pfam04471 710421004621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710421004622 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710421004623 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 710421004624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421004625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710421004626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421004627 DNA binding residues [nucleotide binding] 710421004628 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421004629 anti sigma factor interaction site; other site 710421004630 regulatory phosphorylation site [posttranslational modification]; other site 710421004631 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 710421004632 metal-binding site 710421004633 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 710421004634 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421004635 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710421004636 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710421004637 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710421004638 carboxyltransferase (CT) interaction site; other site 710421004639 biotinylation site [posttranslational modification]; other site 710421004640 ERCC4 domain; Region: ERCC4; smart00891 710421004641 Lsr2; Region: Lsr2; pfam11774 710421004642 Fe-S metabolism associated domain; Region: SufE; cl00951 710421004643 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710421004644 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710421004645 active site residue [active] 710421004646 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710421004647 active site residue [active] 710421004648 VCBS repeat; Region: VCBS_repeat; TIGR01965 710421004649 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710421004650 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004651 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421004652 Chain length determinant protein; Region: Wzz; cl15801 710421004653 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 710421004654 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 710421004655 O-Antigen ligase; Region: Wzy_C; pfam04932 710421004656 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710421004657 active site 710421004658 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 710421004659 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 710421004660 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 710421004661 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 710421004662 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421004663 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421004664 active site 710421004665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421004666 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421004667 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421004668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421004669 NAD(P) binding site [chemical binding]; other site 710421004670 active site 710421004671 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 710421004672 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421004673 Maf-like protein; Region: Maf; pfam02545 710421004674 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 710421004675 active site 710421004676 dimer interface [polypeptide binding]; other site 710421004677 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 710421004678 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710421004679 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710421004680 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421004681 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 710421004682 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 710421004683 Chain length determinant protein; Region: Wzz; pfam02706 710421004684 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 710421004685 Transposase [DNA replication, recombination, and repair]; Region: COG5421 710421004686 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710421004687 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710421004688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421004689 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710421004690 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421004691 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710421004692 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 710421004693 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710421004694 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710421004695 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421004696 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710421004697 Probable Catalytic site; other site 710421004698 metal-binding site 710421004699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421004700 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710421004701 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710421004702 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710421004703 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710421004704 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 710421004705 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421004706 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 710421004707 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 710421004708 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 710421004709 NADP binding site [chemical binding]; other site 710421004710 active site 710421004711 putative substrate binding site [chemical binding]; other site 710421004712 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 710421004713 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 710421004714 NAD binding site [chemical binding]; other site 710421004715 substrate binding site [chemical binding]; other site 710421004716 homodimer interface [polypeptide binding]; other site 710421004717 active site 710421004718 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 710421004719 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 710421004720 substrate binding site; other site 710421004721 tetramer interface; other site 710421004722 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421004723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421004724 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421004725 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710421004726 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 710421004727 active site 710421004728 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710421004729 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710421004730 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421004731 GAF domain; Region: GAF; pfam01590 710421004732 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710421004733 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710421004734 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 710421004735 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 710421004736 catalytic residue [active] 710421004737 putative FPP diphosphate binding site; other site 710421004738 putative FPP binding hydrophobic cleft; other site 710421004739 dimer interface [polypeptide binding]; other site 710421004740 putative IPP diphosphate binding site; other site 710421004741 hypothetical protein; Provisional; Region: PRK07208 710421004742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421004743 Bacterial PH domain; Region: DUF304; pfam03703 710421004744 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 710421004745 putative active site [active] 710421004746 Predicted membrane protein [Function unknown]; Region: COG2246 710421004747 GtrA-like protein; Region: GtrA; pfam04138 710421004748 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 710421004749 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421004750 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 710421004751 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421004752 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 710421004753 FAD binding site [chemical binding]; other site 710421004754 homotetramer interface [polypeptide binding]; other site 710421004755 substrate binding pocket [chemical binding]; other site 710421004756 catalytic base [active] 710421004757 Phospholipid methyltransferase; Region: PEMT; cl17370 710421004758 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 710421004759 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 710421004760 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 710421004761 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 710421004762 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 710421004763 TIGR03089 family protein; Region: TIGR03089 710421004764 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710421004765 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710421004766 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 710421004767 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 710421004768 NADP binding site [chemical binding]; other site 710421004769 active site 710421004770 putative substrate binding site [chemical binding]; other site 710421004771 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421004772 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 710421004773 Probable Catalytic site; other site 710421004774 metal-binding site 710421004775 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 710421004776 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 710421004777 active site 710421004778 Substrate binding site; other site 710421004779 Mg++ binding site; other site 710421004780 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710421004781 putative CoA binding site [chemical binding]; other site 710421004782 MspA; Region: MspA; pfam09203 710421004783 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 710421004784 nudix motif; other site 710421004785 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 710421004786 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 710421004787 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 710421004788 FMN binding site [chemical binding]; other site 710421004789 dimer interface [polypeptide binding]; other site 710421004790 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 710421004791 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 710421004792 dimer interface [polypeptide binding]; other site 710421004793 phosphate binding site [ion binding]; other site 710421004794 Transcription factor WhiB; Region: Whib; pfam02467 710421004795 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 710421004796 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 710421004797 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 710421004798 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 710421004799 active site 710421004800 substrate binding site [chemical binding]; other site 710421004801 metal binding site [ion binding]; metal-binding site 710421004802 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 710421004803 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710421004804 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710421004805 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 710421004806 hypothetical protein; Provisional; Region: PRK07236 710421004807 amino acid transporter; Region: 2A0306; TIGR00909 710421004808 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 710421004809 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 710421004810 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710421004811 Di-iron ligands [ion binding]; other site 710421004812 Rubredoxin [Energy production and conversion]; Region: COG1773 710421004813 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 710421004814 iron binding site [ion binding]; other site 710421004815 Rubredoxin [Energy production and conversion]; Region: COG1773 710421004816 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 710421004817 iron binding site [ion binding]; other site 710421004818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004820 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 710421004821 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 710421004822 homotetramer interface [polypeptide binding]; other site 710421004823 ligand binding site [chemical binding]; other site 710421004824 catalytic site [active] 710421004825 NAD binding site [chemical binding]; other site 710421004826 long-chain acyl-CoA synthetase; Region: PLN02736 710421004827 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421004828 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421004829 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 710421004830 TMP-binding site; other site 710421004831 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 710421004832 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421004833 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421004834 DNA binding residues [nucleotide binding] 710421004835 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710421004836 iron-sulfur cluster [ion binding]; other site 710421004837 [2Fe-2S] cluster binding site [ion binding]; other site 710421004838 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710421004839 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710421004840 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710421004841 active site 710421004842 metal binding site [ion binding]; metal-binding site 710421004843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421004844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421004845 active site 710421004846 phosphorylation site [posttranslational modification] 710421004847 intermolecular recognition site; other site 710421004848 dimerization interface [polypeptide binding]; other site 710421004849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421004850 DNA binding site [nucleotide binding] 710421004851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421004852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421004853 dimerization interface [polypeptide binding]; other site 710421004854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421004855 dimer interface [polypeptide binding]; other site 710421004856 phosphorylation site [posttranslational modification] 710421004857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421004858 ATP binding site [chemical binding]; other site 710421004859 Mg2+ binding site [ion binding]; other site 710421004860 G-X-G motif; other site 710421004861 lipoprotein LpqB; Provisional; Region: PRK13616 710421004862 Sporulation and spore germination; Region: Germane; pfam10646 710421004863 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710421004864 iron-sulfur cluster [ion binding]; other site 710421004865 [2Fe-2S] cluster binding site [ion binding]; other site 710421004866 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710421004867 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 710421004868 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 710421004869 30S subunit binding site; other site 710421004870 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 710421004871 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 710421004872 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421004873 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421004874 BCCT family transporter; Region: BCCT; pfam02028 710421004875 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 710421004876 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710421004877 FAD binding pocket [chemical binding]; other site 710421004878 FAD binding motif [chemical binding]; other site 710421004879 phosphate binding motif [ion binding]; other site 710421004880 beta-alpha-beta structure motif; other site 710421004881 NAD binding pocket [chemical binding]; other site 710421004882 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421004883 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710421004884 catalytic loop [active] 710421004885 iron binding site [ion binding]; other site 710421004886 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 710421004887 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 710421004888 putative di-iron ligands [ion binding]; other site 710421004889 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 710421004890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710421004891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710421004892 active site 710421004893 catalytic tetrad [active] 710421004894 Predicted GTPases [General function prediction only]; Region: COG1162 710421004895 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 710421004896 GTPase/Zn-binding domain interface [polypeptide binding]; other site 710421004897 GTP/Mg2+ binding site [chemical binding]; other site 710421004898 G4 box; other site 710421004899 G5 box; other site 710421004900 G1 box; other site 710421004901 Switch I region; other site 710421004902 G2 box; other site 710421004903 G3 box; other site 710421004904 Switch II region; other site 710421004905 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 710421004906 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 710421004907 hinge; other site 710421004908 active site 710421004909 Uncharacterized conserved protein [Function unknown]; Region: COG2135 710421004910 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 710421004911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421004912 S-adenosylmethionine binding site [chemical binding]; other site 710421004913 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 710421004914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421004915 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421004916 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 710421004917 NAD(P) binding site [chemical binding]; other site 710421004918 catalytic residues [active] 710421004919 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710421004920 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710421004921 NAD binding site [chemical binding]; other site 710421004922 catalytic Zn binding site [ion binding]; other site 710421004923 substrate binding site [chemical binding]; other site 710421004924 structural Zn binding site [ion binding]; other site 710421004925 short chain dehydrogenase; Provisional; Region: PRK08278 710421004926 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 710421004927 NAD(P) binding site [chemical binding]; other site 710421004928 homodimer interface [polypeptide binding]; other site 710421004929 active site 710421004930 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 710421004931 putative deacylase active site [active] 710421004932 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710421004933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421004934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421004935 DNA binding residues [nucleotide binding] 710421004936 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 710421004937 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710421004938 carboxyltransferase (CT) interaction site; other site 710421004939 biotinylation site [posttranslational modification]; other site 710421004940 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 710421004941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 710421004942 Histidine kinase; Region: HisKA_2; pfam07568 710421004943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421004944 ATP binding site [chemical binding]; other site 710421004945 Mg2+ binding site [ion binding]; other site 710421004946 G-X-G motif; other site 710421004947 Transcription factor WhiB; Region: Whib; pfam02467 710421004948 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 710421004949 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710421004950 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 710421004951 Dehydroquinase class II; Region: DHquinase_II; pfam01220 710421004952 active site 710421004953 trimer interface [polypeptide binding]; other site 710421004954 dimer interface [polypeptide binding]; other site 710421004955 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710421004956 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710421004957 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421004958 catalytic core [active] 710421004959 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710421004960 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421004961 P-loop; other site 710421004962 Magnesium ion binding site [ion binding]; other site 710421004963 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421004964 Magnesium ion binding site [ion binding]; other site 710421004965 PQQ-like domain; Region: PQQ_2; pfam13360 710421004966 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710421004967 DEAD-like helicases superfamily; Region: DEXDc; smart00487 710421004968 ATP binding site [chemical binding]; other site 710421004969 Mg++ binding site [ion binding]; other site 710421004970 motif III; other site 710421004971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421004972 nucleotide binding region [chemical binding]; other site 710421004973 ATP-binding site [chemical binding]; other site 710421004974 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 710421004975 dinuclear metal binding motif [ion binding]; other site 710421004976 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 710421004977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421004978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421004979 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 710421004980 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421004981 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421004982 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 710421004983 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 710421004984 ATP binding site [chemical binding]; other site 710421004985 substrate interface [chemical binding]; other site 710421004986 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421004987 active site residue [active] 710421004988 TIGR02569 family protein; Region: TIGR02569_actnb 710421004989 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710421004990 active site 710421004991 DNA binding site [nucleotide binding] 710421004992 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421004993 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710421004994 catalytic site [active] 710421004995 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 710421004996 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710421004997 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710421004998 Part of AAA domain; Region: AAA_19; pfam13245 710421004999 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 710421005000 Predicted membrane protein [Function unknown]; Region: COG4270 710421005001 Ion channel; Region: Ion_trans_2; pfam07885 710421005002 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 710421005003 TrkA-N domain; Region: TrkA_N; pfam02254 710421005004 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 710421005005 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 710421005006 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 710421005007 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 710421005008 putative NADH binding site [chemical binding]; other site 710421005009 putative active site [active] 710421005010 nudix motif; other site 710421005011 putative metal binding site [ion binding]; other site 710421005012 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710421005013 catalytic residues [active] 710421005014 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 710421005015 Family description; Region: UvrD_C_2; pfam13538 710421005016 HRDC domain; Region: HRDC; pfam00570 710421005017 Transcription factor WhiB; Region: Whib; pfam02467 710421005018 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 710421005019 ABC1 family; Region: ABC1; pfam03109 710421005020 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 710421005021 active site 710421005022 ATP binding site [chemical binding]; other site 710421005023 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 710421005024 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 710421005025 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 710421005026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710421005027 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710421005028 hypothetical protein; Validated; Region: PRK00068 710421005029 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 710421005030 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710421005031 DNA binding site [nucleotide binding] 710421005032 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710421005033 Predicted ATPase [General function prediction only]; Region: COG3899 710421005034 AAA ATPase domain; Region: AAA_16; pfam13191 710421005035 Walker A motif; other site 710421005036 ATP binding site [chemical binding]; other site 710421005037 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710421005038 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710421005039 FAD binding domain; Region: FAD_binding_4; pfam01565 710421005040 heat shock protein 90; Provisional; Region: PRK05218 710421005041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421005042 ATP binding site [chemical binding]; other site 710421005043 Mg2+ binding site [ion binding]; other site 710421005044 G-X-G motif; other site 710421005045 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005046 mce related protein; Region: MCE; pfam02470 710421005047 mce related protein; Region: MCE; pfam02470 710421005048 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421005049 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710421005050 mce related protein; Region: MCE; pfam02470 710421005051 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005052 mce related protein; Region: MCE; pfam02470 710421005053 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005054 mce related protein; Region: MCE; pfam02470 710421005055 mce related protein; Region: MCE; pfam02470 710421005056 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421005057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005059 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421005060 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421005061 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421005062 Cytochrome P450; Region: p450; cl12078 710421005063 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421005064 Cytochrome P450; Region: p450; cl12078 710421005065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005066 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 710421005067 DNA-binding interface [nucleotide binding]; DNA binding site 710421005068 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 710421005069 Subunit I/III interface [polypeptide binding]; other site 710421005070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421005073 substrate binding pocket [chemical binding]; other site 710421005074 catalytic triad [active] 710421005075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421005076 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710421005077 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421005078 thioredoxin 2; Provisional; Region: PRK10996 710421005079 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710421005080 catalytic residues [active] 710421005081 MarR family; Region: MarR; pfam01047 710421005082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421005083 putative substrate translocation pore; other site 710421005084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421005085 putative substrate translocation pore; other site 710421005086 Domain of unknown function (DUF336); Region: DUF336; cl01249 710421005087 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421005088 PE-PPE domain; Region: PE-PPE; pfam08237 710421005089 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 710421005090 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421005091 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421005092 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 710421005093 Predicted membrane protein [Function unknown]; Region: COG3174 710421005094 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 710421005095 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710421005096 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421005097 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 710421005098 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421005099 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 710421005100 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 710421005101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421005102 motif II; other site 710421005103 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710421005104 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 710421005105 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 710421005106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710421005107 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421005108 active site residue [active] 710421005109 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710421005110 sulfite oxidase; Provisional; Region: PLN00177 710421005111 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 710421005112 Moco binding site; other site 710421005113 metal coordination site [ion binding]; other site 710421005114 dimerization interface [polypeptide binding]; other site 710421005115 peroxiredoxin; Provisional; Region: PRK13189 710421005116 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 710421005117 dimer interface [polypeptide binding]; other site 710421005118 decamer (pentamer of dimers) interface [polypeptide binding]; other site 710421005119 catalytic triad [active] 710421005120 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 710421005121 Cation efflux family; Region: Cation_efflux; cl00316 710421005122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421005123 dimerization interface [polypeptide binding]; other site 710421005124 putative DNA binding site [nucleotide binding]; other site 710421005125 putative Zn2+ binding site [ion binding]; other site 710421005126 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421005127 anti sigma factor interaction site; other site 710421005128 regulatory phosphorylation site [posttranslational modification]; other site 710421005129 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 710421005130 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421005131 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421005132 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 710421005133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421005134 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 710421005135 Winged helix-turn helix; Region: HTH_29; pfam13551 710421005136 Integrase core domain; Region: rve; pfam00665 710421005137 Integrase core domain; Region: rve_3; pfam13683 710421005138 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421005139 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710421005140 GAF domain; Region: GAF_3; pfam13492 710421005141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421005142 Histidine kinase; Region: HisKA_3; pfam07730 710421005143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421005144 ATP binding site [chemical binding]; other site 710421005145 Mg2+ binding site [ion binding]; other site 710421005146 G-X-G motif; other site 710421005147 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 710421005148 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 710421005149 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005150 Ligand Binding Site [chemical binding]; other site 710421005151 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710421005152 dimer interface [polypeptide binding]; other site 710421005153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710421005154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421005155 Coenzyme A binding pocket [chemical binding]; other site 710421005156 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710421005157 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421005158 NAD(P) binding site [chemical binding]; other site 710421005159 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005160 Ligand Binding Site [chemical binding]; other site 710421005161 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005162 Ligand Binding Site [chemical binding]; other site 710421005163 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710421005164 dimer interface [polypeptide binding]; other site 710421005165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 710421005166 Predicted kinase [General function prediction only]; Region: COG0645 710421005167 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005168 Ligand Binding Site [chemical binding]; other site 710421005169 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005170 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005171 Ligand Binding Site [chemical binding]; other site 710421005172 Universal stress protein family; Region: Usp; pfam00582 710421005173 Ligand Binding Site [chemical binding]; other site 710421005174 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 710421005175 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421005176 Hemerythrin-like domain; Region: Hr-like; cd12108 710421005177 phosphoenolpyruvate synthase; Validated; Region: PRK06464 710421005178 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 710421005179 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 710421005180 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710421005181 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 710421005182 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 710421005183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421005184 active site 710421005185 motif I; other site 710421005186 motif II; other site 710421005187 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710421005188 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 710421005189 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 710421005190 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 710421005191 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 710421005192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421005193 active site 710421005194 Erythromycin esterase; Region: Erythro_esteras; pfam05139 710421005195 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 710421005196 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 710421005197 putative substrate binding site [chemical binding]; other site 710421005198 putative ATP binding site [chemical binding]; other site 710421005199 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421005200 GAF domain; Region: GAF; pfam01590 710421005201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421005202 Histidine kinase; Region: HisKA_3; pfam07730 710421005203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421005204 ATP binding site [chemical binding]; other site 710421005205 Mg2+ binding site [ion binding]; other site 710421005206 G-X-G motif; other site 710421005207 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421005208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421005209 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421005210 classical (c) SDRs; Region: SDR_c; cd05233 710421005211 NAD(P) binding site [chemical binding]; other site 710421005212 active site 710421005213 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421005214 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 710421005215 homotetramer interface [polypeptide binding]; other site 710421005216 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421005217 NAD binding site [chemical binding]; other site 710421005218 homodimer interface [polypeptide binding]; other site 710421005219 active site 710421005220 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 710421005221 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 710421005222 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710421005223 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710421005224 NAD(P) binding site [chemical binding]; other site 710421005225 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421005226 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421005227 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710421005228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421005229 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710421005230 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421005231 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421005232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421005233 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710421005234 putative active site [active] 710421005235 putative substrate binding site [chemical binding]; other site 710421005236 ATP binding site [chemical binding]; other site 710421005237 Phosphotransferase enzyme family; Region: APH; pfam01636 710421005238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005240 enoyl-CoA hydratase; Provisional; Region: PRK06190 710421005241 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005242 substrate binding site [chemical binding]; other site 710421005243 oxyanion hole (OAH) forming residues; other site 710421005244 trimer interface [polypeptide binding]; other site 710421005245 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 710421005246 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421005247 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 710421005248 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421005249 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 710421005250 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 710421005251 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421005252 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 710421005253 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 710421005254 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 710421005255 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 710421005256 4Fe-4S binding domain; Region: Fer4; pfam00037 710421005257 4Fe-4S binding domain; Region: Fer4; pfam00037 710421005258 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 710421005259 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 710421005260 NADH dehydrogenase subunit G; Validated; Region: PRK07860 710421005261 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421005262 catalytic loop [active] 710421005263 iron binding site [ion binding]; other site 710421005264 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 710421005265 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421005266 molybdopterin cofactor binding site; other site 710421005267 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 710421005268 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 710421005269 SLBB domain; Region: SLBB; pfam10531 710421005270 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 710421005271 NADH dehydrogenase subunit E; Validated; Region: PRK07539 710421005272 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 710421005273 putative dimer interface [polypeptide binding]; other site 710421005274 [2Fe-2S] cluster binding site [ion binding]; other site 710421005275 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 710421005276 NADH dehydrogenase subunit D; Validated; Region: PRK06075 710421005277 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 710421005278 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 710421005279 NADH dehydrogenase subunit B; Validated; Region: PRK06411 710421005280 NADH dehydrogenase subunit A; Validated; Region: PRK07928 710421005281 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710421005282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421005283 active site 710421005284 phosphorylation site [posttranslational modification] 710421005285 intermolecular recognition site; other site 710421005286 dimerization interface [polypeptide binding]; other site 710421005287 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710421005288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421005289 S-adenosylmethionine binding site [chemical binding]; other site 710421005290 Phosphotransferase enzyme family; Region: APH; pfam01636 710421005291 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710421005292 putative active site [active] 710421005293 putative substrate binding site [chemical binding]; other site 710421005294 ATP binding site [chemical binding]; other site 710421005295 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005296 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421005297 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421005298 active site 710421005299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005301 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 710421005302 active site 710421005303 catalytic residues [active] 710421005304 metal binding site [ion binding]; metal-binding site 710421005305 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421005306 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421005307 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710421005308 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 710421005309 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710421005310 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005311 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005312 active site 710421005313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005315 Predicted esterase [General function prediction only]; Region: COG0627 710421005316 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 710421005317 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 710421005318 NADP binding site [chemical binding]; other site 710421005319 dimer interface [polypeptide binding]; other site 710421005320 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421005321 cyclase homology domain; Region: CHD; cd07302 710421005322 nucleotidyl binding site; other site 710421005323 metal binding site [ion binding]; metal-binding site 710421005324 dimer interface [polypeptide binding]; other site 710421005325 Predicted ATPase [General function prediction only]; Region: COG3899 710421005326 AAA ATPase domain; Region: AAA_16; pfam13191 710421005327 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710421005328 active site 710421005329 TDP-binding site; other site 710421005330 acceptor substrate-binding pocket; other site 710421005331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005333 active site 710421005334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005336 active site 710421005337 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 710421005338 active site 710421005339 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710421005340 ferredoxin-NADP+ reductase; Region: PLN02852 710421005341 peptide chain release factor 2; Validated; Region: prfB; PRK00578 710421005342 Alpha C protein N terminal; Region: AlphaC_N; pfam08829 710421005343 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710421005344 RF-1 domain; Region: RF-1; pfam00472 710421005345 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710421005346 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710421005347 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 710421005348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421005349 Walker A/P-loop; other site 710421005350 ATP binding site [chemical binding]; other site 710421005351 Q-loop/lid; other site 710421005352 ABC transporter signature motif; other site 710421005353 Walker B; other site 710421005354 D-loop; other site 710421005355 H-loop/switch region; other site 710421005356 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 710421005357 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 710421005358 FtsX-like permease family; Region: FtsX; pfam02687 710421005359 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 710421005360 SmpB-tmRNA interface; other site 710421005361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421005362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421005363 metal binding site [ion binding]; metal-binding site 710421005364 active site 710421005365 I-site; other site 710421005366 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 710421005367 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421005368 CoenzymeA binding site [chemical binding]; other site 710421005369 subunit interaction site [polypeptide binding]; other site 710421005370 PHB binding site; other site 710421005371 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710421005372 Predicted transcriptional regulators [Transcription]; Region: COG1695 710421005373 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 710421005374 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421005375 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421005376 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 710421005377 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710421005378 hydrophobic ligand binding site; other site 710421005379 short chain dehydrogenase; Provisional; Region: PRK12939 710421005380 classical (c) SDRs; Region: SDR_c; cd05233 710421005381 NAD(P) binding site [chemical binding]; other site 710421005382 active site 710421005383 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421005384 classical (c) SDRs; Region: SDR_c; cd05233 710421005385 NAD(P) binding site [chemical binding]; other site 710421005386 active site 710421005387 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710421005388 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421005389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005390 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005391 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005392 active site 710421005393 enoyl-CoA hydratase; Provisional; Region: PRK09245 710421005394 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005395 substrate binding site [chemical binding]; other site 710421005396 oxyanion hole (OAH) forming residues; other site 710421005397 trimer interface [polypeptide binding]; other site 710421005398 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 710421005399 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421005400 NAD binding site [chemical binding]; other site 710421005401 catalytic residues [active] 710421005402 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 710421005403 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421005404 catalytic Zn binding site [ion binding]; other site 710421005405 structural Zn binding site [ion binding]; other site 710421005406 tetramer interface [polypeptide binding]; other site 710421005407 acyl-CoA synthetase; Validated; Region: PRK08316 710421005408 TIGR03089 family protein; Region: TIGR03089 710421005409 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421005410 acyl-activating enzyme (AAE) consensus motif; other site 710421005411 putative AMP binding site [chemical binding]; other site 710421005412 putative active site [active] 710421005413 putative CoA binding site [chemical binding]; other site 710421005414 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421005415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421005416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421005417 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 710421005418 NAD(P) binding site [chemical binding]; other site 710421005419 active site 710421005420 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 710421005421 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710421005422 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 710421005423 active site 710421005424 FMN binding site [chemical binding]; other site 710421005425 substrate binding site [chemical binding]; other site 710421005426 putative catalytic residue [active] 710421005427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421005428 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421005429 substrate binding pocket [chemical binding]; other site 710421005430 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421005431 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710421005432 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710421005433 Bacterial transcriptional regulator; Region: IclR; pfam01614 710421005434 hypothetical protein; Validated; Region: PRK07121 710421005435 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421005436 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710421005437 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710421005438 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710421005439 active site 710421005440 Fe binding site [ion binding]; other site 710421005441 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005442 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005443 active site 710421005444 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 710421005445 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 710421005446 FAD binding pocket [chemical binding]; other site 710421005447 FAD binding motif [chemical binding]; other site 710421005448 phosphate binding motif [ion binding]; other site 710421005449 beta-alpha-beta structure motif; other site 710421005450 NAD(p) ribose binding residues [chemical binding]; other site 710421005451 NAD binding pocket [chemical binding]; other site 710421005452 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 710421005453 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421005454 catalytic loop [active] 710421005455 iron binding site [ion binding]; other site 710421005456 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421005457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421005458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421005459 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710421005460 NAD(P) binding site [chemical binding]; other site 710421005461 active site 710421005462 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 710421005463 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 710421005464 active site 710421005465 catalytic residues [active] 710421005466 metal binding site [ion binding]; metal-binding site 710421005467 DmpG-like communication domain; Region: DmpG_comm; pfam07836 710421005468 acetaldehyde dehydrogenase; Validated; Region: PRK08300 710421005469 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710421005470 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 710421005471 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421005472 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710421005473 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421005474 Permease; Region: Permease; pfam02405 710421005475 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421005476 Permease; Region: Permease; pfam02405 710421005477 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005478 mce related protein; Region: MCE; pfam02470 710421005479 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421005480 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005481 mce related protein; Region: MCE; pfam02470 710421005482 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005483 mce related protein; Region: MCE; pfam02470 710421005484 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005485 mce related protein; Region: MCE; pfam02470 710421005486 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005487 mce related protein; Region: MCE; pfam02470 710421005488 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421005489 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421005490 mce related protein; Region: MCE; pfam02470 710421005491 enoyl-CoA hydratase; Provisional; Region: PRK08290 710421005492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005493 substrate binding site [chemical binding]; other site 710421005494 oxyanion hole (OAH) forming residues; other site 710421005495 trimer interface [polypeptide binding]; other site 710421005496 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 710421005497 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710421005498 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 710421005499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421005500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421005501 active site 710421005502 ATP binding site [chemical binding]; other site 710421005503 substrate binding site [chemical binding]; other site 710421005504 activation loop (A-loop); other site 710421005505 Predicted esterase [General function prediction only]; Region: COG0627 710421005506 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 710421005507 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 710421005508 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421005509 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710421005510 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421005511 amino acid transporter; Region: 2A0306; TIGR00909 710421005512 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421005513 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 710421005514 active site 710421005515 PAS fold; Region: PAS_3; pfam08447 710421005516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 710421005517 putative active site [active] 710421005518 heme pocket [chemical binding]; other site 710421005519 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710421005520 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421005521 anti sigma factor interaction site; other site 710421005522 regulatory phosphorylation site [posttranslational modification]; other site 710421005523 PAS fold; Region: PAS_4; pfam08448 710421005524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421005525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421005526 dimer interface [polypeptide binding]; other site 710421005527 phosphorylation site [posttranslational modification] 710421005528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421005529 ATP binding site [chemical binding]; other site 710421005530 Mg2+ binding site [ion binding]; other site 710421005531 G-X-G motif; other site 710421005532 Response regulator receiver domain; Region: Response_reg; pfam00072 710421005533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421005534 active site 710421005535 phosphorylation site [posttranslational modification] 710421005536 intermolecular recognition site; other site 710421005537 dimerization interface [polypeptide binding]; other site 710421005538 PAS domain S-box; Region: sensory_box; TIGR00229 710421005539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710421005540 putative active site [active] 710421005541 heme pocket [chemical binding]; other site 710421005542 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710421005543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710421005544 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710421005545 ATP binding site [chemical binding]; other site 710421005546 Mg2+ binding site [ion binding]; other site 710421005547 G-X-G motif; other site 710421005548 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421005549 anti sigma factor interaction site; other site 710421005550 regulatory phosphorylation site [posttranslational modification]; other site 710421005551 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 710421005552 nucleotide binding site [chemical binding]; other site 710421005553 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421005554 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 710421005555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421005556 motif II; other site 710421005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 710421005558 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 710421005559 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 710421005560 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710421005561 Predicted esterase [General function prediction only]; Region: COG0627 710421005562 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 710421005563 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 710421005564 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 710421005565 camphor resistance protein CrcB; Provisional; Region: PRK14228 710421005566 camphor resistance protein CrcB; Provisional; Region: PRK14216 710421005567 phosphoglucomutase; Validated; Region: PRK07564 710421005568 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 710421005569 active site 710421005570 substrate binding site [chemical binding]; other site 710421005571 metal binding site [ion binding]; metal-binding site 710421005572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421005573 putative substrate translocation pore; other site 710421005574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421005575 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 710421005576 Protein of unknown function (DUF737); Region: DUF737; pfam05300 710421005577 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 710421005578 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 710421005579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421005580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421005581 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710421005582 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 710421005583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005585 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 710421005586 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 710421005587 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710421005588 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710421005589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710421005590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421005591 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710421005592 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710421005593 acyl-activating enzyme (AAE) consensus motif; other site 710421005594 putative AMP binding site [chemical binding]; other site 710421005595 putative active site [active] 710421005596 putative CoA binding site [chemical binding]; other site 710421005597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 710421005598 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710421005599 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421005600 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421005601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421005602 DNA binding residues [nucleotide binding] 710421005603 dimerization interface [polypeptide binding]; other site 710421005604 Predicted membrane protein [Function unknown]; Region: COG1289 710421005605 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710421005606 EamA-like transporter family; Region: EamA; pfam00892 710421005607 Predicted permease [General function prediction only]; Region: COG3329 710421005608 Transport protein; Region: actII; TIGR00833 710421005609 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 710421005610 Ferredoxin [Energy production and conversion]; Region: COG1146 710421005611 4Fe-4S binding domain; Region: Fer4; pfam00037 710421005612 Predicted transcriptional regulator [Transcription]; Region: COG2345 710421005613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 710421005614 DNA binding residues [nucleotide binding] 710421005615 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 710421005616 heme-binding site [chemical binding]; other site 710421005617 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710421005618 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710421005619 hypothetical protein; Provisional; Region: PRK06062 710421005620 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421005621 inhibitor-cofactor binding pocket; inhibition site 710421005622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421005623 catalytic residue [active] 710421005624 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710421005625 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710421005626 tetrameric interface [polypeptide binding]; other site 710421005627 NAD binding site [chemical binding]; other site 710421005628 catalytic residues [active] 710421005629 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 710421005630 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421005631 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710421005632 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 710421005633 homodimer interface [polypeptide binding]; other site 710421005634 homotetramer interface [polypeptide binding]; other site 710421005635 active site pocket [active] 710421005636 cleavage site 710421005637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005639 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 710421005640 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 710421005641 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 710421005642 active site 710421005643 catalytic triad [active] 710421005644 calcium binding site [ion binding]; other site 710421005645 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 710421005646 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 710421005647 putative active site [active] 710421005648 metal binding site [ion binding]; metal-binding site 710421005649 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 710421005650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421005651 motif II; other site 710421005652 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 710421005653 nickel binding site [ion binding]; other site 710421005654 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 710421005655 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 710421005656 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 710421005657 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 710421005658 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 710421005659 FAD binding pocket [chemical binding]; other site 710421005660 FAD binding motif [chemical binding]; other site 710421005661 phosphate binding motif [ion binding]; other site 710421005662 beta-alpha-beta structure motif; other site 710421005663 NAD binding pocket [chemical binding]; other site 710421005664 Iron coordination center [ion binding]; other site 710421005665 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 710421005666 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421005667 anti sigma factor interaction site; other site 710421005668 regulatory phosphorylation site [posttranslational modification]; other site 710421005669 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710421005670 putative catalytic site [active] 710421005671 putative metal binding site [ion binding]; other site 710421005672 putative phosphate binding site [ion binding]; other site 710421005673 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005674 Ligand Binding Site [chemical binding]; other site 710421005675 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421005676 Ligand Binding Site [chemical binding]; other site 710421005677 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710421005678 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421005679 active site 710421005680 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710421005681 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005682 active site 710421005683 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 710421005684 GAF domain; Region: GAF; pfam01590 710421005685 GAF domain; Region: GAF_2; pfam13185 710421005686 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421005687 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421005688 metal binding site [ion binding]; metal-binding site 710421005689 active site 710421005690 I-site; other site 710421005691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 710421005692 hypothetical protein; Provisional; Region: PRK07877 710421005693 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 710421005694 ATP binding site [chemical binding]; other site 710421005695 substrate interface [chemical binding]; other site 710421005696 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 710421005697 putative active site [active] 710421005698 putative catalytic site [active] 710421005699 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 710421005700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421005701 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 710421005702 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421005703 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421005704 classical (c) SDRs; Region: SDR_c; cd05233 710421005705 NAD(P) binding site [chemical binding]; other site 710421005706 active site 710421005707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005708 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005709 active site 710421005710 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421005711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421005712 NAD(P) binding site [chemical binding]; other site 710421005713 active site 710421005714 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 710421005715 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421005716 dimer interface [polypeptide binding]; other site 710421005717 active site 710421005718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005719 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005720 active site 710421005721 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710421005722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421005723 DNA-binding site [nucleotide binding]; DNA binding site 710421005724 FCD domain; Region: FCD; pfam07729 710421005725 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421005726 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421005727 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421005728 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421005729 acyl-activating enzyme (AAE) consensus motif; other site 710421005730 AMP binding site [chemical binding]; other site 710421005731 active site 710421005732 CoA binding site [chemical binding]; other site 710421005733 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421005734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421005735 acyl-activating enzyme (AAE) consensus motif; other site 710421005736 AMP binding site [chemical binding]; other site 710421005737 active site 710421005738 CoA binding site [chemical binding]; other site 710421005739 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421005740 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421005741 acyl-activating enzyme (AAE) consensus motif; other site 710421005742 AMP binding site [chemical binding]; other site 710421005743 active site 710421005744 CoA binding site [chemical binding]; other site 710421005745 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421005746 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005747 substrate binding site [chemical binding]; other site 710421005748 oxyanion hole (OAH) forming residues; other site 710421005749 trimer interface [polypeptide binding]; other site 710421005750 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421005751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005752 substrate binding site [chemical binding]; other site 710421005753 oxyanion hole (OAH) forming residues; other site 710421005754 trimer interface [polypeptide binding]; other site 710421005755 enoyl-CoA hydratase; Provisional; Region: PRK06688 710421005756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005757 substrate binding site [chemical binding]; other site 710421005758 oxyanion hole (OAH) forming residues; other site 710421005759 trimer interface [polypeptide binding]; other site 710421005760 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710421005761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421005762 DNA-binding site [nucleotide binding]; DNA binding site 710421005763 FCD domain; Region: FCD; pfam07729 710421005764 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005765 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710421005766 substrate binding site [chemical binding]; other site 710421005767 oxyanion hole (OAH) forming residues; other site 710421005768 trimer interface [polypeptide binding]; other site 710421005769 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421005770 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710421005771 dimer interface [polypeptide binding]; other site 710421005772 active site 710421005773 tetracycline repressor protein TetR; Provisional; Region: PRK13756 710421005774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005775 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710421005776 enoyl-CoA hydratase; Provisional; Region: PRK08252 710421005777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005778 substrate binding site [chemical binding]; other site 710421005779 oxyanion hole (OAH) forming residues; other site 710421005780 trimer interface [polypeptide binding]; other site 710421005781 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421005782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421005783 NAD(P) binding site [chemical binding]; other site 710421005784 active site 710421005785 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710421005786 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 710421005787 active site 710421005788 inhibitor site; inhibition site 710421005789 dimer interface [polypeptide binding]; other site 710421005790 catalytic residue [active] 710421005791 enoyl-CoA hydratase; Provisional; Region: PRK06210 710421005792 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421005793 substrate binding site [chemical binding]; other site 710421005794 oxyanion hole (OAH) forming residues; other site 710421005795 trimer interface [polypeptide binding]; other site 710421005796 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421005797 acyl-CoA synthetase; Validated; Region: PRK07798 710421005798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421005799 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710421005800 acyl-activating enzyme (AAE) consensus motif; other site 710421005801 acyl-activating enzyme (AAE) consensus motif; other site 710421005802 putative AMP binding site [chemical binding]; other site 710421005803 putative active site [active] 710421005804 putative CoA binding site [chemical binding]; other site 710421005805 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 710421005806 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710421005807 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421005808 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005809 active site 710421005810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421005811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421005812 active site 710421005813 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710421005814 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421005815 active site 710421005816 YacP-like NYN domain; Region: NYN_YacP; cl01491 710421005817 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710421005818 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421005819 molybdopterin cofactor binding site; other site 710421005820 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710421005821 molybdopterin cofactor binding site; other site 710421005822 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710421005823 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 710421005824 active site 710421005825 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 710421005826 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421005827 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421005828 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710421005829 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710421005830 NAD binding site [chemical binding]; other site 710421005831 catalytic residues [active] 710421005832 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421005833 Cytochrome P450; Region: p450; cl12078 710421005834 acyl-CoA synthetase; Validated; Region: PRK07798 710421005835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421005836 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710421005837 acyl-activating enzyme (AAE) consensus motif; other site 710421005838 acyl-activating enzyme (AAE) consensus motif; other site 710421005839 putative AMP binding site [chemical binding]; other site 710421005840 putative active site [active] 710421005841 putative CoA binding site [chemical binding]; other site 710421005842 Isochorismatase family; Region: Isochorismatase; pfam00857 710421005843 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710421005844 catalytic triad [active] 710421005845 conserved cis-peptide bond; other site 710421005846 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421005847 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421005848 [2Fe-2S] cluster binding site [ion binding]; other site 710421005849 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421005850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421005851 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 710421005852 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421005853 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 710421005854 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421005855 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421005856 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710421005857 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710421005858 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421005859 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 710421005860 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421005861 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421005862 Cytochrome P450; Region: p450; cl12078 710421005863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421005864 metabolite-proton symporter; Region: 2A0106; TIGR00883 710421005865 putative substrate translocation pore; other site 710421005866 Protein of unknown function (DUF466); Region: DUF466; cl01082 710421005867 carbon starvation protein A; Provisional; Region: PRK15015 710421005868 Carbon starvation protein CstA; Region: CstA; pfam02554 710421005869 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 710421005870 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 710421005871 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 710421005872 active site 710421005873 DNA binding site [nucleotide binding] 710421005874 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 710421005875 DNA binding site [nucleotide binding] 710421005876 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 710421005877 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 710421005878 Moco binding site; other site 710421005879 metal coordination site [ion binding]; other site 710421005880 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710421005881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421005882 NAD(P) binding site [chemical binding]; other site 710421005883 active site 710421005884 Phosphotransferase enzyme family; Region: APH; pfam01636 710421005885 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710421005886 putative active site [active] 710421005887 putative substrate binding site [chemical binding]; other site 710421005888 ATP binding site [chemical binding]; other site 710421005889 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710421005890 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710421005891 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710421005892 MarR family; Region: MarR; pfam01047 710421005893 Glucose dehydrogenase; Region: glucose_DH; cd08230 710421005894 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421005895 NADP binding site [chemical binding]; other site 710421005896 catalytic Zn binding site [ion binding]; other site 710421005897 structural Zn binding site [ion binding]; other site 710421005898 dimer interface [polypeptide binding]; other site 710421005899 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710421005900 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710421005901 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421005902 Cytochrome P450; Region: p450; cl12078 710421005903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005905 short chain dehydrogenase; Provisional; Region: PRK07832 710421005906 classical (c) SDRs; Region: SDR_c; cd05233 710421005907 NAD(P) binding site [chemical binding]; other site 710421005908 active site 710421005909 Predicted ATPase [General function prediction only]; Region: COG4637 710421005910 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 710421005911 DNA polymerase IV; Validated; Region: PRK03352 710421005912 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710421005913 active site 710421005914 DNA binding site [nucleotide binding] 710421005915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005916 Predicted flavoprotein [General function prediction only]; Region: COG0431 710421005917 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710421005918 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 710421005919 catalytic residues [active] 710421005920 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 710421005921 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 710421005922 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 710421005923 Class I ribonucleotide reductase; Region: RNR_I; cd01679 710421005924 active site 710421005925 dimer interface [polypeptide binding]; other site 710421005926 catalytic residues [active] 710421005927 effector binding site; other site 710421005928 R2 peptide binding site; other site 710421005929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 710421005930 dimerization interface [polypeptide binding]; other site 710421005931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421005932 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 710421005933 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 710421005934 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421005935 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 710421005936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421005937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421005938 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421005939 cyclase homology domain; Region: CHD; cd07302 710421005940 nucleotidyl binding site; other site 710421005941 metal binding site [ion binding]; metal-binding site 710421005942 dimer interface [polypeptide binding]; other site 710421005943 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 710421005944 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710421005945 Zn2+ binding site [ion binding]; other site 710421005946 Mg2+ binding site [ion binding]; other site 710421005947 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421005948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421005949 DNA binding residues [nucleotide binding] 710421005950 dimerization interface [polypeptide binding]; other site 710421005951 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 710421005952 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710421005953 Walker A/P-loop; other site 710421005954 ATP binding site [chemical binding]; other site 710421005955 Q-loop/lid; other site 710421005956 ABC transporter signature motif; other site 710421005957 Walker B; other site 710421005958 D-loop; other site 710421005959 H-loop/switch region; other site 710421005960 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710421005961 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421005962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421005963 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 710421005964 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 710421005965 dimer interface [polypeptide binding]; other site 710421005966 putative radical transfer pathway; other site 710421005967 diiron center [ion binding]; other site 710421005968 tyrosyl radical; other site 710421005969 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710421005970 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 710421005971 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 710421005972 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 710421005973 putative NAD(P) binding site [chemical binding]; other site 710421005974 putative substrate binding site [chemical binding]; other site 710421005975 catalytic Zn binding site [ion binding]; other site 710421005976 structural Zn binding site [ion binding]; other site 710421005977 dimer interface [polypeptide binding]; other site 710421005978 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 710421005979 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 710421005980 siderophore binding site; other site 710421005981 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710421005982 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710421005983 D-pathway; other site 710421005984 Putative ubiquinol binding site [chemical binding]; other site 710421005985 Low-spin heme (heme b) binding site [chemical binding]; other site 710421005986 Putative water exit pathway; other site 710421005987 Binuclear center (heme o3/CuB) [ion binding]; other site 710421005988 K-pathway; other site 710421005989 Putative proton exit pathway; other site 710421005990 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 710421005991 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 710421005992 phosphoserine phosphatase SerB; Region: serB; TIGR00338 710421005993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421005994 motif II; other site 710421005995 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 710421005996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421005997 DNA-binding site [nucleotide binding]; DNA binding site 710421005998 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421005999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421006000 homodimer interface [polypeptide binding]; other site 710421006001 catalytic residue [active] 710421006002 Predicted membrane protein [Function unknown]; Region: COG2364 710421006003 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 710421006004 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 710421006005 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710421006006 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 710421006007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421006008 Walker A/P-loop; other site 710421006009 ATP binding site [chemical binding]; other site 710421006010 Q-loop/lid; other site 710421006011 ABC transporter signature motif; other site 710421006012 Walker B; other site 710421006013 D-loop; other site 710421006014 H-loop/switch region; other site 710421006015 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710421006016 nudix motif; other site 710421006017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421006018 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421006019 substrate binding site [chemical binding]; other site 710421006020 oxyanion hole (OAH) forming residues; other site 710421006021 trimer interface [polypeptide binding]; other site 710421006022 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710421006023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421006024 S-adenosylmethionine binding site [chemical binding]; other site 710421006025 Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263 710421006026 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 710421006027 FOG: WD40-like repeat [Function unknown]; Region: COG1520 710421006028 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 710421006029 active site 710421006030 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 710421006031 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 710421006032 trimer interface [polypeptide binding]; other site 710421006033 active site 710421006034 substrate binding site [chemical binding]; other site 710421006035 CoA binding site [chemical binding]; other site 710421006036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421006037 dimerization interface [polypeptide binding]; other site 710421006038 putative Zn2+ binding site [ion binding]; other site 710421006039 putative DNA binding site [nucleotide binding]; other site 710421006040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421006041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421006042 putative substrate translocation pore; other site 710421006043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421006044 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421006045 Uncharacterized conserved protein [Function unknown]; Region: COG1543 710421006046 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 710421006047 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 710421006048 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710421006049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421006050 S-adenosylmethionine binding site [chemical binding]; other site 710421006051 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 710421006052 Ligand binding site [chemical binding]; other site 710421006053 Electron transfer flavoprotein domain; Region: ETF; pfam01012 710421006054 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 710421006055 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 710421006056 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 710421006057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 710421006058 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421006059 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710421006060 putative acyl-acceptor binding pocket; other site 710421006061 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 710421006062 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 710421006063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421006064 catalytic residue [active] 710421006065 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 710421006066 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 710421006067 Ligand Binding Site [chemical binding]; other site 710421006068 PknH-like extracellular domain; Region: PknH_C; pfam14032 710421006069 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 710421006070 4-coumarate--CoA ligase; Region: PLN02246 710421006071 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 710421006072 acyl-activating enzyme (AAE) consensus motif; other site 710421006073 active site 710421006074 putative CoA binding site [chemical binding]; other site 710421006075 AMP binding site [chemical binding]; other site 710421006076 Protein of unknown function (DUF419); Region: DUF419; pfam04237 710421006077 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 710421006078 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 710421006079 nucleotide binding pocket [chemical binding]; other site 710421006080 K-X-D-G motif; other site 710421006081 catalytic site [active] 710421006082 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 710421006083 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 710421006084 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 710421006085 Dimer interface [polypeptide binding]; other site 710421006086 BRCT sequence motif; other site 710421006087 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 710421006088 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 710421006089 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710421006090 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 710421006091 6-phosphofructokinase; Provisional; Region: PRK03202 710421006092 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 710421006093 active site 710421006094 ADP/pyrophosphate binding site [chemical binding]; other site 710421006095 dimerization interface [polypeptide binding]; other site 710421006096 allosteric effector site; other site 710421006097 fructose-1,6-bisphosphate binding site; other site 710421006098 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 710421006099 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 710421006100 GatB domain; Region: GatB_Yqey; smart00845 710421006101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421006102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 710421006103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421006104 dimer interface [polypeptide binding]; other site 710421006105 phosphorylation site [posttranslational modification] 710421006106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421006107 ATP binding site [chemical binding]; other site 710421006108 Mg2+ binding site [ion binding]; other site 710421006109 G-X-G motif; other site 710421006110 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 710421006111 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710421006112 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 710421006113 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710421006114 PYR/PP interface [polypeptide binding]; other site 710421006115 dimer interface [polypeptide binding]; other site 710421006116 TPP binding site [chemical binding]; other site 710421006117 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 710421006118 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 710421006119 TPP-binding site [chemical binding]; other site 710421006120 dimer interface [polypeptide binding]; other site 710421006121 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 710421006122 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 710421006123 putative valine binding site [chemical binding]; other site 710421006124 dimer interface [polypeptide binding]; other site 710421006125 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 710421006126 ketol-acid reductoisomerase; Provisional; Region: PRK05479 710421006127 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 710421006128 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 710421006129 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710421006130 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710421006131 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710421006132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421006133 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 710421006134 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 710421006135 ligand binding site [chemical binding]; other site 710421006136 NAD binding site [chemical binding]; other site 710421006137 dimerization interface [polypeptide binding]; other site 710421006138 catalytic site [active] 710421006139 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 710421006140 putative L-serine binding site [chemical binding]; other site 710421006141 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 710421006142 tartrate dehydrogenase; Region: TTC; TIGR02089 710421006143 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 710421006144 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 710421006145 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710421006146 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 710421006147 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710421006148 HIGH motif; other site 710421006149 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710421006150 active site 710421006151 KMSKS motif; other site 710421006152 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710421006153 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710421006154 Bacterial transcriptional regulator; Region: IclR; pfam01614 710421006155 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 710421006156 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 710421006157 substrate binding site [chemical binding]; other site 710421006158 ligand binding site [chemical binding]; other site 710421006159 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 710421006160 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 710421006161 substrate binding site [chemical binding]; other site 710421006162 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 710421006163 IHF - DNA interface [nucleotide binding]; other site 710421006164 IHF dimer interface [polypeptide binding]; other site 710421006165 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710421006166 active site 710421006167 Ap6A binding site [chemical binding]; other site 710421006168 nudix motif; other site 710421006169 metal binding site [ion binding]; metal-binding site 710421006170 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421006171 catalytic core [active] 710421006172 polyphosphate kinase; Provisional; Region: PRK05443 710421006173 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 710421006174 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 710421006175 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 710421006176 putative domain interface [polypeptide binding]; other site 710421006177 putative active site [active] 710421006178 catalytic site [active] 710421006179 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710421006180 putative active site [active] 710421006181 catalytic site [active] 710421006182 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 710421006183 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 710421006184 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710421006185 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710421006186 cystathionine gamma-lyase; Validated; Region: PRK07582 710421006187 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421006188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421006189 catalytic residue [active] 710421006190 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 710421006191 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 710421006192 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 710421006193 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 710421006194 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710421006195 AsnC family; Region: AsnC_trans_reg; pfam01037 710421006196 thiamine monophosphate kinase; Provisional; Region: PRK05731 710421006197 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 710421006198 ATP binding site [chemical binding]; other site 710421006199 dimerization interface [polypeptide binding]; other site 710421006200 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 710421006201 ligand binding site [chemical binding]; other site 710421006202 active site 710421006203 UGI interface [polypeptide binding]; other site 710421006204 catalytic site [active] 710421006205 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 710421006206 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 710421006207 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 710421006208 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 710421006209 ssDNA binding site; other site 710421006210 generic binding surface II; other site 710421006211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421006212 ATP binding site [chemical binding]; other site 710421006213 putative Mg++ binding site [ion binding]; other site 710421006214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421006215 nucleotide binding region [chemical binding]; other site 710421006216 ATP-binding site [chemical binding]; other site 710421006217 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 710421006218 Penicillinase repressor; Region: Pencillinase_R; pfam03965 710421006219 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 710421006220 Thioredoxin; Region: Thioredoxin_4; pfam13462 710421006221 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710421006222 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710421006223 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710421006224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421006225 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421006226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421006227 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710421006228 DNA binding residues [nucleotide binding] 710421006229 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710421006230 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710421006231 metal-binding site [ion binding] 710421006232 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421006233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421006234 motif II; other site 710421006235 Predicted membrane protein [Function unknown]; Region: COG3336 710421006236 Predicted integral membrane protein [Function unknown]; Region: COG5660 710421006237 Putative zinc-finger; Region: zf-HC2; pfam13490 710421006238 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 710421006239 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 710421006240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710421006241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710421006242 active site 710421006243 catalytic tetrad [active] 710421006244 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421006245 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421006246 substrate binding pocket [chemical binding]; other site 710421006247 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421006248 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 710421006249 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 710421006250 catalytic residues [active] 710421006251 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 710421006252 putative active site [active] 710421006253 redox center [active] 710421006254 pyruvate carboxylase; Reviewed; Region: PRK12999 710421006255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421006256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421006257 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710421006258 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 710421006259 active site 710421006260 catalytic residues [active] 710421006261 metal binding site [ion binding]; metal-binding site 710421006262 homodimer binding site [polypeptide binding]; other site 710421006263 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710421006264 carboxyltransferase (CT) interaction site; other site 710421006265 biotinylation site [posttranslational modification]; other site 710421006266 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 710421006267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421006268 S-adenosylmethionine binding site [chemical binding]; other site 710421006269 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 710421006270 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 710421006271 active site 710421006272 (T/H)XGH motif; other site 710421006273 Hemerythrin-like domain; Region: Hr-like; cd12108 710421006274 Fe binding site [ion binding]; other site 710421006275 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 710421006276 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 710421006277 ribonuclease III; Reviewed; Region: rnc; PRK00102 710421006278 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 710421006279 dimerization interface [polypeptide binding]; other site 710421006280 active site 710421006281 metal binding site [ion binding]; metal-binding site 710421006282 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 710421006283 dsRNA binding site [nucleotide binding]; other site 710421006284 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 710421006285 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 710421006286 DNA binding site [nucleotide binding] 710421006287 catalytic residue [active] 710421006288 H2TH interface [polypeptide binding]; other site 710421006289 putative catalytic residues [active] 710421006290 turnover-facilitating residue; other site 710421006291 intercalation triad [nucleotide binding]; other site 710421006292 8OG recognition residue [nucleotide binding]; other site 710421006293 putative reading head residues; other site 710421006294 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710421006295 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710421006296 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 710421006297 acylphosphatase; Provisional; Region: PRK14422 710421006298 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710421006299 AAA domain; Region: AAA_23; pfam13476 710421006300 Walker A/P-loop; other site 710421006301 ATP binding site [chemical binding]; other site 710421006302 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710421006303 ABC transporter signature motif; other site 710421006304 Walker B; other site 710421006305 D-loop; other site 710421006306 H-loop/switch region; other site 710421006307 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 710421006308 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 710421006309 homotetramer interface [polypeptide binding]; other site 710421006310 FMN binding site [chemical binding]; other site 710421006311 homodimer contacts [polypeptide binding]; other site 710421006312 putative active site [active] 710421006313 putative substrate binding site [chemical binding]; other site 710421006314 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 710421006315 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 710421006316 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710421006317 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710421006318 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 710421006319 Nitrogen regulatory protein P-II; Region: P-II; smart00938 710421006320 PII uridylyl-transferase; Provisional; Region: PRK03381 710421006321 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710421006322 metal binding triad; other site 710421006323 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710421006324 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 710421006325 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710421006326 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 710421006327 signal recognition particle protein; Provisional; Region: PRK10867 710421006328 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 710421006329 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 710421006330 P loop; other site 710421006331 GTP binding site [chemical binding]; other site 710421006332 Signal peptide binding domain; Region: SRP_SPB; pfam02978 710421006333 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710421006334 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710421006335 active site 710421006336 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710421006337 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710421006338 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710421006339 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 710421006340 SnoaL-like domain; Region: SnoaL_3; pfam13474 710421006341 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710421006342 SnoaL-like domain; Region: SnoaL_4; pfam13577 710421006343 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 710421006344 hypothetical protein; Provisional; Region: PRK02821 710421006345 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 710421006346 G-X-X-G motif; other site 710421006347 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 710421006348 RimM N-terminal domain; Region: RimM; pfam01782 710421006349 PRC-barrel domain; Region: PRC; pfam05239 710421006350 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 710421006351 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 710421006352 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 710421006353 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710421006354 Catalytic site [active] 710421006355 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710421006356 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 710421006357 RNA/DNA hybrid binding site [nucleotide binding]; other site 710421006358 active site 710421006359 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 710421006360 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421006361 mce related protein; Region: MCE; pfam02470 710421006362 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421006363 mce related protein; Region: MCE; pfam02470 710421006364 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421006365 mce related protein; Region: MCE; pfam02470 710421006366 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421006367 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710421006368 mce related protein; Region: MCE; pfam02470 710421006369 mce related protein; Region: MCE; pfam02470 710421006370 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421006371 mce related protein; Region: MCE; pfam02470 710421006372 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421006373 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710421006374 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421006375 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421006376 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710421006377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421006378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421006379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421006380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421006381 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421006382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421006383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421006384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421006385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421006386 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 710421006387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421006388 NAD(P) binding site [chemical binding]; other site 710421006389 active site 710421006390 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421006391 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421006392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421006393 active site 710421006394 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421006395 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710421006396 FAD binding site [chemical binding]; other site 710421006397 substrate binding site [chemical binding]; other site 710421006398 catalytic base [active] 710421006399 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710421006400 metal ion-dependent adhesion site (MIDAS); other site 710421006401 MoxR-like ATPases [General function prediction only]; Region: COG0714 710421006402 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 710421006403 Walker A motif; other site 710421006404 ATP binding site [chemical binding]; other site 710421006405 Walker B motif; other site 710421006406 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 710421006407 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710421006408 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 710421006409 ligand binding site [chemical binding]; other site 710421006410 short chain dehydrogenase; Provisional; Region: PRK06179 710421006411 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 710421006412 NADP binding site [chemical binding]; other site 710421006413 active site 710421006414 steroid binding site; other site 710421006415 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710421006416 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710421006417 NAD binding site [chemical binding]; other site 710421006418 catalytic residues [active] 710421006419 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421006420 Cytochrome P450; Region: p450; cl12078 710421006421 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421006422 Cytochrome P450; Region: p450; cl12078 710421006423 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421006424 classical (c) SDRs; Region: SDR_c; cd05233 710421006425 NAD(P) binding site [chemical binding]; other site 710421006426 active site 710421006427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421006428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421006429 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421006430 Cytochrome P450; Region: p450; cl12078 710421006431 patatin-related protein; Region: TIGR03607 710421006432 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710421006433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421006434 UMP phosphatase; Provisional; Region: PRK10444 710421006435 active site 710421006436 motif I; other site 710421006437 motif II; other site 710421006438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421006439 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 710421006440 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421006441 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710421006442 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710421006443 active site 710421006444 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710421006445 catalytic triad [active] 710421006446 dimer interface [polypeptide binding]; other site 710421006447 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710421006448 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710421006449 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710421006450 hypothetical protein; Reviewed; Region: PRK12497 710421006451 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 710421006452 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710421006453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421006454 Walker A motif; other site 710421006455 ATP binding site [chemical binding]; other site 710421006456 Walker B motif; other site 710421006457 arginine finger; other site 710421006458 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 710421006459 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 710421006460 DNA protecting protein DprA; Region: dprA; TIGR00732 710421006461 PAS domain S-box; Region: sensory_box; TIGR00229 710421006462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710421006463 putative active site [active] 710421006464 heme pocket [chemical binding]; other site 710421006465 PAS domain; Region: PAS_9; pfam13426 710421006466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421006467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421006468 metal binding site [ion binding]; metal-binding site 710421006469 active site 710421006470 I-site; other site 710421006471 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710421006472 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710421006473 active site 710421006474 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 710421006475 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 710421006476 FAD binding pocket [chemical binding]; other site 710421006477 FAD binding motif [chemical binding]; other site 710421006478 phosphate binding motif [ion binding]; other site 710421006479 NAD binding pocket [chemical binding]; other site 710421006480 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 710421006481 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 710421006482 putative active site [active] 710421006483 putative substrate binding site [chemical binding]; other site 710421006484 putative FMN binding site [chemical binding]; other site 710421006485 putative catalytic residues [active] 710421006486 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 710421006487 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421006488 active site 710421006489 DNA binding site [nucleotide binding] 710421006490 Int/Topo IB signature motif; other site 710421006491 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710421006492 Peptidase family M23; Region: Peptidase_M23; pfam01551 710421006493 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 710421006494 rRNA interaction site [nucleotide binding]; other site 710421006495 S8 interaction site; other site 710421006496 putative laminin-1 binding site; other site 710421006497 elongation factor Ts; Provisional; Region: tsf; PRK09377 710421006498 Elongation factor TS; Region: EF_TS; pfam00889 710421006499 Elongation factor TS; Region: EF_TS; pfam00889 710421006500 amidase; Provisional; Region: PRK07869 710421006501 Amidase; Region: Amidase; pfam01425 710421006502 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710421006503 MarR family; Region: MarR; pfam01047 710421006504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710421006505 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 710421006506 putative nucleotide binding site [chemical binding]; other site 710421006507 uridine monophosphate binding site [chemical binding]; other site 710421006508 homohexameric interface [polypeptide binding]; other site 710421006509 ribosome recycling factor; Reviewed; Region: frr; PRK00083 710421006510 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 710421006511 hinge region; other site 710421006512 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 710421006513 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 710421006514 EamA-like transporter family; Region: EamA; pfam00892 710421006515 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 710421006516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421006517 FeS/SAM binding site; other site 710421006518 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710421006519 SnoaL-like domain; Region: SnoaL_3; pfam13474 710421006520 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710421006521 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710421006522 NAD binding site [chemical binding]; other site 710421006523 catalytic residues [active] 710421006524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421006525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421006526 Ecdysteroid kinase; Region: EcKinase; cl17738 710421006527 Phosphotransferase enzyme family; Region: APH; pfam01636 710421006528 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421006529 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421006530 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710421006531 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 710421006532 Strictosidine synthase; Region: Str_synth; pfam03088 710421006533 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421006534 Cytochrome P450; Region: p450; cl12078 710421006535 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710421006536 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421006537 NAD(P) binding site [chemical binding]; other site 710421006538 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 710421006539 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710421006540 classical (c) SDRs; Region: SDR_c; cd05233 710421006541 NAD(P) binding site [chemical binding]; other site 710421006542 active site 710421006543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421006544 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421006545 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421006546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421006547 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421006548 active site 710421006549 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421006550 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421006551 active site 710421006552 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421006553 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710421006554 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421006555 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421006556 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 710421006557 Prostaglandin dehydrogenases; Region: PGDH; cd05288 710421006558 NAD(P) binding site [chemical binding]; other site 710421006559 substrate binding site [chemical binding]; other site 710421006560 dimer interface [polypeptide binding]; other site 710421006561 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710421006562 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710421006563 active site 710421006564 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710421006565 catalytic triad [active] 710421006566 dimer interface [polypeptide binding]; other site 710421006567 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710421006568 hydrophobic ligand binding site; other site 710421006569 Domain of unknown function (DUF427); Region: DUF427; pfam04248 710421006570 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421006571 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421006572 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710421006573 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 710421006574 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421006575 classical (c) SDRs; Region: SDR_c; cd05233 710421006576 NAD(P) binding site [chemical binding]; other site 710421006577 active site 710421006578 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 710421006579 DNA photolyase; Region: DNA_photolyase; pfam00875 710421006580 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 710421006581 Fasciclin domain; Region: Fasciclin; pfam02469 710421006582 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 710421006583 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 710421006584 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 710421006585 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 710421006586 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 710421006587 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 710421006588 active site 710421006589 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 710421006590 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710421006591 active site 710421006592 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710421006593 putative substrate binding region [chemical binding]; other site 710421006594 putative substrate binding region [chemical binding]; other site 710421006595 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 710421006596 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710421006597 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710421006598 Predicted acetyltransferase [General function prediction only]; Region: COG3393 710421006599 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 710421006600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710421006601 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 710421006602 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 710421006603 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710421006604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710421006605 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710421006606 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421006607 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710421006608 CoenzymeA binding site [chemical binding]; other site 710421006609 subunit interaction site [polypeptide binding]; other site 710421006610 PHB binding site; other site 710421006611 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710421006612 active site 710421006613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421006614 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 710421006615 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710421006616 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421006617 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 710421006618 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710421006619 active site 710421006620 dimer interface [polypeptide binding]; other site 710421006621 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710421006622 Ligand Binding Site [chemical binding]; other site 710421006623 Molecular Tunnel; other site 710421006624 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 710421006625 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710421006626 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710421006627 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710421006628 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 710421006629 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 710421006630 catalytic triad [active] 710421006631 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421006632 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710421006633 NAD(P) binding site [chemical binding]; other site 710421006634 catalytic residues [active] 710421006635 short chain dehydrogenase; Provisional; Region: PRK06057 710421006636 classical (c) SDRs; Region: SDR_c; cd05233 710421006637 NAD(P) binding site [chemical binding]; other site 710421006638 active site 710421006639 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710421006640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421006641 DNA-binding site [nucleotide binding]; DNA binding site 710421006642 FCD domain; Region: FCD; pfam07729 710421006643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421006644 dimerization interface [polypeptide binding]; other site 710421006645 putative DNA binding site [nucleotide binding]; other site 710421006646 putative Zn2+ binding site [ion binding]; other site 710421006647 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 710421006648 active site 710421006649 ATP binding site [chemical binding]; other site 710421006650 substrate binding site [chemical binding]; other site 710421006651 dimer interface [polypeptide binding]; other site 710421006652 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710421006653 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710421006654 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 710421006655 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 710421006656 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710421006657 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 710421006658 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 710421006659 PDGLE domain; Region: PDGLE; pfam13190 710421006660 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 710421006661 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710421006662 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710421006663 Walker A/P-loop; other site 710421006664 ATP binding site [chemical binding]; other site 710421006665 Q-loop/lid; other site 710421006666 ABC transporter signature motif; other site 710421006667 Walker B; other site 710421006668 D-loop; other site 710421006669 H-loop/switch region; other site 710421006670 mycothione reductase; Reviewed; Region: PRK07846 710421006671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421006672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421006673 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421006674 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710421006675 malate:quinone oxidoreductase; Validated; Region: PRK05257 710421006676 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 710421006677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710421006678 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 710421006679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421006680 Walker A motif; other site 710421006681 ATP binding site [chemical binding]; other site 710421006682 Walker B motif; other site 710421006683 arginine finger; other site 710421006684 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 710421006685 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 710421006686 metal ion-dependent adhesion site (MIDAS); other site 710421006687 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 710421006688 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 710421006689 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 710421006690 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 710421006691 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 710421006692 catalytic triad [active] 710421006693 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 710421006694 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 710421006695 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 710421006696 homodimer interface [polypeptide binding]; other site 710421006697 active site 710421006698 SAM binding site [chemical binding]; other site 710421006699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421006700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421006701 putative substrate translocation pore; other site 710421006702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421006703 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710421006704 prolyl-tRNA synthetase; Provisional; Region: PRK09194 710421006705 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 710421006706 dimer interface [polypeptide binding]; other site 710421006707 motif 1; other site 710421006708 active site 710421006709 motif 2; other site 710421006710 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 710421006711 putative deacylase active site [active] 710421006712 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710421006713 active site 710421006714 motif 3; other site 710421006715 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 710421006716 anticodon binding site; other site 710421006717 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710421006718 ribosome maturation protein RimP; Reviewed; Region: PRK00092 710421006719 Sm and related proteins; Region: Sm_like; cl00259 710421006720 heptamer interface [polypeptide binding]; other site 710421006721 Sm1 motif; other site 710421006722 hexamer interface [polypeptide binding]; other site 710421006723 RNA binding site [nucleotide binding]; other site 710421006724 Sm2 motif; other site 710421006725 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 710421006726 NusA N-terminal domain; Region: NusA_N; pfam08529 710421006727 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 710421006728 RNA binding site [nucleotide binding]; other site 710421006729 homodimer interface [polypeptide binding]; other site 710421006730 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710421006731 G-X-X-G motif; other site 710421006732 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710421006733 G-X-X-G motif; other site 710421006734 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 710421006735 putative RNA binding cleft [nucleotide binding]; other site 710421006736 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710421006737 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 710421006738 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 710421006739 G1 box; other site 710421006740 putative GEF interaction site [polypeptide binding]; other site 710421006741 GTP/Mg2+ binding site [chemical binding]; other site 710421006742 Switch I region; other site 710421006743 G2 box; other site 710421006744 G3 box; other site 710421006745 Switch II region; other site 710421006746 G4 box; other site 710421006747 G5 box; other site 710421006748 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 710421006749 Translation-initiation factor 2; Region: IF-2; pfam11987 710421006750 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 710421006751 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 710421006752 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 710421006753 DHH family; Region: DHH; pfam01368 710421006754 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 710421006755 putative efflux protein, MATE family; Region: matE; TIGR00797 710421006756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421006757 S-adenosylmethionine binding site [chemical binding]; other site 710421006758 enoyl-CoA hydratase; Provisional; Region: PRK06190 710421006759 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421006760 substrate binding site [chemical binding]; other site 710421006761 oxyanion hole (OAH) forming residues; other site 710421006762 trimer interface [polypeptide binding]; other site 710421006763 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 710421006764 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 710421006765 Predicted acyl esterases [General function prediction only]; Region: COG2936 710421006766 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710421006767 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710421006768 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 710421006769 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710421006770 active site 710421006771 metal binding site [ion binding]; metal-binding site 710421006772 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 710421006773 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 710421006774 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 710421006775 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 710421006776 RNA binding site [nucleotide binding]; other site 710421006777 active site 710421006778 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 710421006779 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421006780 hydrophobic ligand binding site; other site 710421006781 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 710421006782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421006783 putative DNA binding site [nucleotide binding]; other site 710421006784 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 710421006785 FeoA domain; Region: FeoA; pfam04023 710421006786 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 710421006787 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 710421006788 active site 710421006789 Riboflavin kinase; Region: Flavokinase; pfam01687 710421006790 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 710421006791 16S/18S rRNA binding site [nucleotide binding]; other site 710421006792 S13e-L30e interaction site [polypeptide binding]; other site 710421006793 25S rRNA binding site [nucleotide binding]; other site 710421006794 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 710421006795 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 710421006796 oligomer interface [polypeptide binding]; other site 710421006797 RNA binding site [nucleotide binding]; other site 710421006798 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 710421006799 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 710421006800 RNase E interface [polypeptide binding]; other site 710421006801 trimer interface [polypeptide binding]; other site 710421006802 active site 710421006803 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 710421006804 putative nucleic acid binding region [nucleotide binding]; other site 710421006805 G-X-X-G motif; other site 710421006806 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 710421006807 RNA binding site [nucleotide binding]; other site 710421006808 domain interface; other site 710421006809 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 710421006810 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 710421006811 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 710421006812 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 710421006813 GXWXG protein; Region: GXWXG; pfam14231 710421006814 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 710421006815 hypothetical protein; Provisional; Region: PRK01842 710421006816 SEC-C motif; Region: SEC-C; pfam02810 710421006817 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 710421006818 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 710421006819 hexamer interface [polypeptide binding]; other site 710421006820 ligand binding site [chemical binding]; other site 710421006821 putative active site [active] 710421006822 NAD(P) binding site [chemical binding]; other site 710421006823 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 710421006824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421006825 putative DNA binding site [nucleotide binding]; other site 710421006826 putative Zn2+ binding site [ion binding]; other site 710421006827 AsnC family; Region: AsnC_trans_reg; pfam01037 710421006828 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421006829 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421006830 dihydrodipicolinate reductase; Provisional; Region: PRK00048 710421006831 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710421006832 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 710421006833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 710421006834 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 710421006835 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710421006836 Dienelactone hydrolase family; Region: DLH; pfam01738 710421006837 thymidylate synthase; Reviewed; Region: thyA; PRK01827 710421006838 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 710421006839 dimerization interface [polypeptide binding]; other site 710421006840 active site 710421006841 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 710421006842 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710421006843 folate binding site [chemical binding]; other site 710421006844 NADP+ binding site [chemical binding]; other site 710421006845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 710421006846 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710421006847 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 710421006848 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 710421006849 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 710421006850 dimer interface [polypeptide binding]; other site 710421006851 active site 710421006852 catalytic residue [active] 710421006853 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710421006854 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421006855 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710421006856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421006857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421006858 active site 710421006859 phosphorylation site [posttranslational modification] 710421006860 intermolecular recognition site; other site 710421006861 dimerization interface [polypeptide binding]; other site 710421006862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421006863 DNA binding site [nucleotide binding] 710421006864 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421006865 Leucine carboxyl methyltransferase; Region: LCM; cl01306 710421006866 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 710421006867 classical (c) SDRs; Region: SDR_c; cd05233 710421006868 NAD(P) binding site [chemical binding]; other site 710421006869 active site 710421006870 Uncharacterized conserved protein [Function unknown]; Region: COG1359 710421006871 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 710421006872 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 710421006873 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710421006874 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 710421006875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421006876 Coenzyme A binding pocket [chemical binding]; other site 710421006877 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 710421006878 Competence-damaged protein; Region: CinA; pfam02464 710421006879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421006880 non-specific DNA binding site [nucleotide binding]; other site 710421006881 salt bridge; other site 710421006882 sequence-specific DNA binding site [nucleotide binding]; other site 710421006883 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 710421006884 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710421006885 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710421006886 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710421006887 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 710421006888 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 710421006889 dimerization interface [polypeptide binding]; other site 710421006890 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 710421006891 ATP binding site [chemical binding]; other site 710421006892 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 710421006893 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 710421006894 HupF/HypC family; Region: HupF_HypC; pfam01455 710421006895 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 710421006896 Acylphosphatase; Region: Acylphosphatase; cl00551 710421006897 HypF finger; Region: zf-HYPF; pfam07503 710421006898 HypF finger; Region: zf-HYPF; pfam07503 710421006899 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 710421006900 HupF/HypC family; Region: HupF_HypC; pfam01455 710421006901 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 710421006902 nickel binding site [ion binding]; other site 710421006903 NifU-like domain; Region: NifU; cl00484 710421006904 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710421006905 iron-sulfur cluster [ion binding]; other site 710421006906 [2Fe-2S] cluster binding site [ion binding]; other site 710421006907 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 710421006908 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 710421006909 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 710421006910 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710421006911 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 710421006912 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 710421006913 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710421006914 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421006915 recombinase A; Provisional; Region: recA; PRK09354 710421006916 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 710421006917 hexamer interface [polypeptide binding]; other site 710421006918 Walker A motif; other site 710421006919 ATP binding site [chemical binding]; other site 710421006920 Walker B motif; other site 710421006921 recombination regulator RecX; Reviewed; Region: recX; PRK00117 710421006922 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 710421006923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421006924 dimer interface [polypeptide binding]; other site 710421006925 conserved gate region; other site 710421006926 putative PBP binding loops; other site 710421006927 ABC-ATPase subunit interface; other site 710421006928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421006929 dimer interface [polypeptide binding]; other site 710421006930 conserved gate region; other site 710421006931 putative PBP binding loops; other site 710421006932 ABC-ATPase subunit interface; other site 710421006933 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 710421006934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421006935 substrate binding pocket [chemical binding]; other site 710421006936 membrane-bound complex binding site; other site 710421006937 hinge residues; other site 710421006938 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710421006939 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710421006940 Walker A/P-loop; other site 710421006941 ATP binding site [chemical binding]; other site 710421006942 Q-loop/lid; other site 710421006943 ABC transporter signature motif; other site 710421006944 Walker B; other site 710421006945 D-loop; other site 710421006946 H-loop/switch region; other site 710421006947 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 710421006948 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 710421006949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421006950 FeS/SAM binding site; other site 710421006951 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710421006952 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710421006953 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 710421006954 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 710421006955 active site 710421006956 metal binding site [ion binding]; metal-binding site 710421006957 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 710421006958 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 710421006959 diaminopimelate epimerase; Region: DapF; TIGR00652 710421006960 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710421006961 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 710421006962 GTPases [General function prediction only]; Region: HflX; COG2262 710421006963 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 710421006964 HflX GTPase family; Region: HflX; cd01878 710421006965 G1 box; other site 710421006966 GTP/Mg2+ binding site [chemical binding]; other site 710421006967 Switch I region; other site 710421006968 G2 box; other site 710421006969 G3 box; other site 710421006970 Switch II region; other site 710421006971 G4 box; other site 710421006972 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 710421006973 G5 box; other site 710421006974 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 710421006975 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 710421006976 molybdopterin cofactor binding site [chemical binding]; other site 710421006977 substrate binding site [chemical binding]; other site 710421006978 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 710421006979 molybdopterin cofactor binding site; other site 710421006980 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421006981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421006982 active site 710421006983 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 710421006984 LGFP repeat; Region: LGFP; pfam08310 710421006985 LGFP repeat; Region: LGFP; pfam08310 710421006986 LGFP repeat; Region: LGFP; pfam08310 710421006987 LGFP repeat; Region: LGFP; pfam08310 710421006988 LexA repressor; Validated; Region: PRK00215 710421006989 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 710421006990 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 710421006991 Catalytic site [active] 710421006992 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 710421006993 ATP cone domain; Region: ATP-cone; pfam03477 710421006994 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 710421006995 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421006996 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710421006997 PAC2 family; Region: PAC2; pfam09754 710421006998 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 710421006999 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 710421007000 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 710421007001 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 710421007002 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 710421007003 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 710421007004 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 710421007005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421007006 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710421007007 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421007008 DNA binding residues [nucleotide binding] 710421007009 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 710421007010 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 710421007011 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 710421007012 Protein of unknown function (DUF952); Region: DUF952; cl01393 710421007013 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 710421007014 homotrimer interaction site [polypeptide binding]; other site 710421007015 putative active site [active] 710421007016 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 710421007017 O-methyltransferase; Region: Methyltransf_2; pfam00891 710421007018 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 710421007019 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421007020 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710421007021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421007022 DNA binding residues [nucleotide binding] 710421007023 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710421007024 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421007025 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 710421007026 active site 710421007027 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710421007028 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 710421007029 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 710421007030 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710421007031 trimer interface [polypeptide binding]; other site 710421007032 active site 710421007033 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 710421007034 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 710421007035 generic binding surface II; other site 710421007036 ssDNA binding site; other site 710421007037 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 710421007038 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710421007039 TrkA-N domain; Region: TrkA_N; pfam02254 710421007040 TrkA-C domain; Region: TrkA_C; pfam02080 710421007041 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710421007042 TrkA-N domain; Region: TrkA_N; pfam02254 710421007043 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710421007044 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 710421007045 TRAM domain; Region: TRAM; cl01282 710421007046 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 710421007047 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 710421007048 transmembrane helices; other site 710421007049 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710421007050 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 710421007051 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 710421007052 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 710421007053 TPP-binding site; other site 710421007054 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710421007055 PYR/PP interface [polypeptide binding]; other site 710421007056 dimer interface [polypeptide binding]; other site 710421007057 TPP binding site [chemical binding]; other site 710421007058 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710421007059 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710421007060 tetramer interface [polypeptide binding]; other site 710421007061 TPP-binding site [chemical binding]; other site 710421007062 heterodimer interface [polypeptide binding]; other site 710421007063 phosphorylation loop region [posttranslational modification] 710421007064 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710421007065 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 710421007066 PYR/PP interface [polypeptide binding]; other site 710421007067 dimer interface [polypeptide binding]; other site 710421007068 TPP binding site [chemical binding]; other site 710421007069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710421007070 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421007071 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 710421007072 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 710421007073 catalytic site [active] 710421007074 putative active site [active] 710421007075 putative substrate binding site [chemical binding]; other site 710421007076 Helicase and RNase D C-terminal; Region: HRDC; smart00341 710421007077 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 710421007078 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 710421007079 substrate binding site [chemical binding]; other site 710421007080 active site 710421007081 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 710421007082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421007083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421007084 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 710421007085 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 710421007086 SelR domain; Region: SelR; pfam01641 710421007087 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 710421007088 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421007089 TAP-like protein; Region: Abhydrolase_4; pfam08386 710421007090 hypothetical protein; Provisional; Region: PRK14059 710421007091 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 710421007092 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 710421007093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 710421007094 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 710421007095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421007096 Coenzyme A binding pocket [chemical binding]; other site 710421007097 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 710421007098 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710421007099 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710421007100 DNA binding site [nucleotide binding] 710421007101 active site 710421007102 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710421007103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421007104 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421007105 DNA binding residues [nucleotide binding] 710421007106 Clp amino terminal domain; Region: Clp_N; pfam02861 710421007107 Helix-turn-helix domain; Region: HTH_18; pfam12833 710421007108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421007109 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421007110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421007111 active site 710421007112 Int/Topo IB signature motif; other site 710421007113 DNA binding site [nucleotide binding] 710421007114 Helix-turn-helix domain; Region: HTH_17; cl17695 710421007115 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 710421007116 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 710421007117 active site 710421007118 metal binding site [ion binding]; metal-binding site 710421007119 interdomain interaction site; other site 710421007120 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 710421007121 Helix-turn-helix domain; Region: HTH_17; pfam12728 710421007122 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421007123 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421007124 Predicted membrane protein [Function unknown]; Region: COG3462 710421007125 Short C-terminal domain; Region: SHOCT; pfam09851 710421007126 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 710421007127 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 710421007128 Multicopper oxidase; Region: Cu-oxidase; pfam00394 710421007129 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 710421007130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421007131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421007132 active site 710421007133 phosphorylation site [posttranslational modification] 710421007134 intermolecular recognition site; other site 710421007135 dimerization interface [polypeptide binding]; other site 710421007136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421007137 DNA binding site [nucleotide binding] 710421007138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421007139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421007140 dimerization interface [polypeptide binding]; other site 710421007141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421007142 dimer interface [polypeptide binding]; other site 710421007143 phosphorylation site [posttranslational modification] 710421007144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421007145 ATP binding site [chemical binding]; other site 710421007146 Mg2+ binding site [ion binding]; other site 710421007147 G-X-G motif; other site 710421007148 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421007149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421007150 active site 710421007151 phosphorylation site [posttranslational modification] 710421007152 intermolecular recognition site; other site 710421007153 dimerization interface [polypeptide binding]; other site 710421007154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421007155 DNA binding site [nucleotide binding] 710421007156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421007157 dimerization interface [polypeptide binding]; other site 710421007158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421007159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421007160 dimer interface [polypeptide binding]; other site 710421007161 phosphorylation site [posttranslational modification] 710421007162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421007163 ATP binding site [chemical binding]; other site 710421007164 Mg2+ binding site [ion binding]; other site 710421007165 G-X-G motif; other site 710421007166 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710421007167 active site 710421007168 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 710421007169 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 710421007170 MspA; Region: MspA; pfam09203 710421007171 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 710421007172 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710421007173 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710421007174 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710421007175 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 710421007176 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421007177 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 710421007178 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 710421007179 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421007180 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 710421007181 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421007182 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710421007183 PAP2 superfamily; Region: PAP2; pfam01569 710421007184 active site 710421007185 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 710421007186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421007187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421007188 motif II; other site 710421007189 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 710421007190 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421007191 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421007192 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710421007193 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710421007194 PhoU domain; Region: PhoU; pfam01895 710421007195 PhoU domain; Region: PhoU; pfam01895 710421007196 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421007197 MspA; Region: MspA; pfam09203 710421007198 MspA; Region: MspA; pfam09203 710421007199 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421007200 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421007201 metal binding site [ion binding]; metal-binding site 710421007202 active site 710421007203 I-site; other site 710421007204 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 710421007205 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421007206 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421007207 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421007208 GAF domain; Region: GAF; pfam01590 710421007209 ANTAR domain; Region: ANTAR; pfam03861 710421007210 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 710421007211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421007212 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710421007213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421007214 DNA binding residues [nucleotide binding] 710421007215 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 710421007216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421007217 Walker A/P-loop; other site 710421007218 ATP binding site [chemical binding]; other site 710421007219 Q-loop/lid; other site 710421007220 ABC transporter signature motif; other site 710421007221 Walker B; other site 710421007222 D-loop; other site 710421007223 H-loop/switch region; other site 710421007224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421007225 putative PBP binding loops; other site 710421007226 ABC-ATPase subunit interface; other site 710421007227 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 710421007228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710421007229 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 710421007230 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710421007231 DNA binding residues [nucleotide binding] 710421007232 TOBE domain; Region: TOBE; cl01440 710421007233 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 710421007234 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710421007235 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 710421007236 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 710421007237 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 710421007238 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710421007239 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710421007240 Walker A/P-loop; other site 710421007241 ATP binding site [chemical binding]; other site 710421007242 Q-loop/lid; other site 710421007243 ABC transporter signature motif; other site 710421007244 Walker B; other site 710421007245 D-loop; other site 710421007246 H-loop/switch region; other site 710421007247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710421007248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421007249 dimer interface [polypeptide binding]; other site 710421007250 conserved gate region; other site 710421007251 putative PBP binding loops; other site 710421007252 ABC-ATPase subunit interface; other site 710421007253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421007254 dimer interface [polypeptide binding]; other site 710421007255 conserved gate region; other site 710421007256 putative PBP binding loops; other site 710421007257 ABC-ATPase subunit interface; other site 710421007258 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710421007259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710421007260 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 710421007261 active site 710421007262 catalytic site [active] 710421007263 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710421007264 dimer interface [polypeptide binding]; other site 710421007265 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421007266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421007267 active site 710421007268 phosphorylation site [posttranslational modification] 710421007269 intermolecular recognition site; other site 710421007270 dimerization interface [polypeptide binding]; other site 710421007271 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421007272 DNA binding residues [nucleotide binding] 710421007273 dimerization interface [polypeptide binding]; other site 710421007274 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421007275 Ligand Binding Site [chemical binding]; other site 710421007276 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710421007277 FMN binding site [chemical binding]; other site 710421007278 dimer interface [polypeptide binding]; other site 710421007279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421007280 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 710421007281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421007282 Histidine kinase; Region: HisKA_3; pfam07730 710421007283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421007284 ATP binding site [chemical binding]; other site 710421007285 Mg2+ binding site [ion binding]; other site 710421007286 G-X-G motif; other site 710421007287 GAF domain; Region: GAF_2; pfam13185 710421007288 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710421007289 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 710421007290 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710421007291 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710421007292 active site 710421007293 catalytic tetrad [active] 710421007294 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421007295 CoenzymeA binding site [chemical binding]; other site 710421007296 subunit interaction site [polypeptide binding]; other site 710421007297 PHB binding site; other site 710421007298 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 710421007299 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 710421007300 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 710421007301 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 710421007302 active site 710421007303 dimer interface [polypeptide binding]; other site 710421007304 motif 1; other site 710421007305 motif 2; other site 710421007306 motif 3; other site 710421007307 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 710421007308 anticodon binding site; other site 710421007309 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 710421007310 nucleotide binding site/active site [active] 710421007311 HIT family signature motif; other site 710421007312 catalytic residue [active] 710421007313 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710421007314 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 710421007315 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 710421007316 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 710421007317 putative acyl-acceptor binding pocket; other site 710421007318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421007319 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421007320 LemA family; Region: LemA; cl00742 710421007321 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710421007322 nudix motif; other site 710421007323 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 710421007324 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 710421007325 active site 710421007326 multimer interface [polypeptide binding]; other site 710421007327 acyl-CoA thioesterase II; Region: tesB; TIGR00189 710421007328 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710421007329 active site 710421007330 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710421007331 catalytic triad [active] 710421007332 dimer interface [polypeptide binding]; other site 710421007333 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 710421007334 predicted active site [active] 710421007335 catalytic triad [active] 710421007336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421007337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421007338 active site 710421007339 Predicted acyl esterases [General function prediction only]; Region: COG2936 710421007340 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421007341 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710421007342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421007343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421007344 hypothetical protein; Validated; Region: PRK00110 710421007345 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 710421007346 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 710421007347 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421007348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421007349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421007350 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 710421007351 active site 710421007352 putative DNA-binding cleft [nucleotide binding]; other site 710421007353 dimer interface [polypeptide binding]; other site 710421007354 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 710421007355 RuvA N terminal domain; Region: RuvA_N; pfam01330 710421007356 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 710421007357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421007358 Walker A motif; other site 710421007359 ATP binding site [chemical binding]; other site 710421007360 Walker B motif; other site 710421007361 arginine finger; other site 710421007362 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 710421007363 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 710421007364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421007365 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710421007366 catalytic site [active] 710421007367 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421007368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421007369 metal binding site [ion binding]; metal-binding site 710421007370 active site 710421007371 I-site; other site 710421007372 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710421007373 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421007374 acyl-activating enzyme (AAE) consensus motif; other site 710421007375 AMP binding site [chemical binding]; other site 710421007376 active site 710421007377 CoA binding site [chemical binding]; other site 710421007378 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421007379 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 710421007380 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 710421007381 putative NAD(P) binding site [chemical binding]; other site 710421007382 active site 710421007383 putative substrate binding site [chemical binding]; other site 710421007384 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 710421007385 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421007386 inhibitor-cofactor binding pocket; inhibition site 710421007387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421007388 catalytic residue [active] 710421007389 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 710421007390 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 710421007391 Protein export membrane protein; Region: SecD_SecF; cl14618 710421007392 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 710421007393 Protein export membrane protein; Region: SecD_SecF; pfam02355 710421007394 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710421007395 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 710421007396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421007397 active site 710421007398 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 710421007399 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710421007400 Zn2+ binding site [ion binding]; other site 710421007401 Mg2+ binding site [ion binding]; other site 710421007402 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710421007403 synthetase active site [active] 710421007404 NTP binding site [chemical binding]; other site 710421007405 metal binding site [ion binding]; metal-binding site 710421007406 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 710421007407 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 710421007408 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 710421007409 active site 710421007410 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710421007411 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 710421007412 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 710421007413 motif 1; other site 710421007414 dimer interface [polypeptide binding]; other site 710421007415 active site 710421007416 motif 2; other site 710421007417 motif 3; other site 710421007418 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 710421007419 anticodon binding site; other site 710421007420 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 710421007421 Predicted membrane protein [Function unknown]; Region: COG4325 710421007422 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 710421007423 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710421007424 Walker A/P-loop; other site 710421007425 ATP binding site [chemical binding]; other site 710421007426 Q-loop/lid; other site 710421007427 ABC transporter signature motif; other site 710421007428 Walker B; other site 710421007429 D-loop; other site 710421007430 H-loop/switch region; other site 710421007431 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 710421007432 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710421007433 Walker A/P-loop; other site 710421007434 ATP binding site [chemical binding]; other site 710421007435 Q-loop/lid; other site 710421007436 ABC transporter signature motif; other site 710421007437 Walker B; other site 710421007438 D-loop; other site 710421007439 H-loop/switch region; other site 710421007440 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710421007441 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710421007442 TM-ABC transporter signature motif; other site 710421007443 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710421007444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710421007445 TM-ABC transporter signature motif; other site 710421007446 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 710421007447 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 710421007448 putative ligand binding site [chemical binding]; other site 710421007449 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 710421007450 Part of AAA domain; Region: AAA_19; pfam13245 710421007451 Family description; Region: UvrD_C_2; pfam13538 710421007452 Radical SAM superfamily; Region: Radical_SAM; pfam04055 710421007453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421007454 FeS/SAM binding site; other site 710421007455 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 710421007456 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 710421007457 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 710421007458 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421007459 inhibitor-cofactor binding pocket; inhibition site 710421007460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421007461 catalytic residue [active] 710421007462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710421007463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421007464 Coenzyme A binding pocket [chemical binding]; other site 710421007465 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421007466 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421007467 active site 710421007468 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421007469 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421007470 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421007471 active site 710421007472 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421007473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421007474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421007475 acyl-CoA thioesterase II; Region: tesB; TIGR00189 710421007476 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710421007477 active site 710421007478 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710421007479 catalytic triad [active] 710421007480 dimer interface [polypeptide binding]; other site 710421007481 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 710421007482 Predicted metalloprotease [General function prediction only]; Region: COG2321 710421007483 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710421007484 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710421007485 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421007486 substrate binding pocket [chemical binding]; other site 710421007487 catalytic triad [active] 710421007488 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710421007489 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421007490 cyclase homology domain; Region: CHD; cd07302 710421007491 nucleotidyl binding site; other site 710421007492 metal binding site [ion binding]; metal-binding site 710421007493 dimer interface [polypeptide binding]; other site 710421007494 Predicted ATPase [General function prediction only]; Region: COG3899 710421007495 AAA ATPase domain; Region: AAA_16; pfam13191 710421007496 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 710421007497 putative hydrophobic ligand binding site [chemical binding]; other site 710421007498 protein interface [polypeptide binding]; other site 710421007499 gate; other site 710421007500 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 710421007501 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 710421007502 dimer interface [polypeptide binding]; other site 710421007503 anticodon binding site; other site 710421007504 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 710421007505 homodimer interface [polypeptide binding]; other site 710421007506 motif 1; other site 710421007507 active site 710421007508 motif 2; other site 710421007509 GAD domain; Region: GAD; pfam02938 710421007510 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710421007511 active site 710421007512 motif 3; other site 710421007513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421007514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421007515 active site 710421007516 phosphorylation site [posttranslational modification] 710421007517 intermolecular recognition site; other site 710421007518 dimerization interface [polypeptide binding]; other site 710421007519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421007520 DNA binding residues [nucleotide binding] 710421007521 dimerization interface [polypeptide binding]; other site 710421007522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421007523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421007524 active site 710421007525 phosphorylation site [posttranslational modification] 710421007526 intermolecular recognition site; other site 710421007527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 710421007528 Histidine kinase; Region: HisKA_3; pfam07730 710421007529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421007530 ATP binding site [chemical binding]; other site 710421007531 Mg2+ binding site [ion binding]; other site 710421007532 G-X-G motif; other site 710421007533 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421007534 cyclase homology domain; Region: CHD; cd07302 710421007535 nucleotidyl binding site; other site 710421007536 metal binding site [ion binding]; metal-binding site 710421007537 dimer interface [polypeptide binding]; other site 710421007538 Predicted ATPase [General function prediction only]; Region: COG3903 710421007539 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710421007540 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710421007541 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421007542 dimer interface [polypeptide binding]; other site 710421007543 active site 710421007544 Predicted transcriptional regulators [Transcription]; Region: COG1733 710421007545 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710421007546 BtpA family; Region: BtpA; cl00440 710421007547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421007548 classical (c) SDRs; Region: SDR_c; cd05233 710421007549 NAD(P) binding site [chemical binding]; other site 710421007550 active site 710421007551 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710421007552 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710421007553 Walker A/P-loop; other site 710421007554 ATP binding site [chemical binding]; other site 710421007555 Q-loop/lid; other site 710421007556 ABC transporter signature motif; other site 710421007557 Walker B; other site 710421007558 D-loop; other site 710421007559 H-loop/switch region; other site 710421007560 TOBE domain; Region: TOBE_2; pfam08402 710421007561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710421007562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421007563 dimer interface [polypeptide binding]; other site 710421007564 conserved gate region; other site 710421007565 putative PBP binding loops; other site 710421007566 ABC-ATPase subunit interface; other site 710421007567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421007568 dimer interface [polypeptide binding]; other site 710421007569 conserved gate region; other site 710421007570 ABC-ATPase subunit interface; other site 710421007571 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710421007572 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710421007573 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 710421007574 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 710421007575 N- and C-terminal domain interface [polypeptide binding]; other site 710421007576 putative active site [active] 710421007577 MgATP binding site [chemical binding]; other site 710421007578 catalytic site [active] 710421007579 metal binding site [ion binding]; metal-binding site 710421007580 putative xylulose binding site [chemical binding]; other site 710421007581 putative homodimer interface [polypeptide binding]; other site 710421007582 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 710421007583 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 710421007584 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710421007585 Domain of unknown function (DUF389); Region: DUF389; cl00781 710421007586 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710421007587 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710421007588 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710421007589 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 710421007590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 710421007591 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 710421007592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 710421007593 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 710421007594 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710421007595 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710421007596 Transglutaminase/protease-like homologues; Region: TGc; smart00460 710421007597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 710421007598 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 710421007599 SnoaL-like domain; Region: SnoaL_4; pfam13577 710421007600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421007601 NAD(P) binding site [chemical binding]; other site 710421007602 active site 710421007603 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 710421007604 recombination factor protein RarA; Reviewed; Region: PRK13342 710421007605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421007606 Walker A motif; other site 710421007607 ATP binding site [chemical binding]; other site 710421007608 Walker B motif; other site 710421007609 arginine finger; other site 710421007610 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 710421007611 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710421007612 FAD binding domain; Region: FAD_binding_4; pfam01565 710421007613 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710421007614 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 710421007615 PYR/PP interface [polypeptide binding]; other site 710421007616 dimer interface [polypeptide binding]; other site 710421007617 TPP binding site [chemical binding]; other site 710421007618 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 710421007619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421007620 putative substrate translocation pore; other site 710421007621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421007622 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710421007623 MarR family; Region: MarR; pfam01047 710421007624 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 710421007625 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 710421007626 Cl- selectivity filter; other site 710421007627 Cl- binding residues [ion binding]; other site 710421007628 pore gating glutamate residue; other site 710421007629 dimer interface [polypeptide binding]; other site 710421007630 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710421007631 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 710421007632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421007633 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710421007634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421007635 DNA binding residues [nucleotide binding] 710421007636 Uncharacterized conserved protein [Function unknown]; Region: COG0432 710421007637 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 710421007638 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 710421007639 motif 1; other site 710421007640 active site 710421007641 motif 2; other site 710421007642 motif 3; other site 710421007643 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 710421007644 DHHA1 domain; Region: DHHA1; pfam02272 710421007645 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 710421007646 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 710421007647 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 710421007648 dimerization interface [polypeptide binding]; other site 710421007649 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 710421007650 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 710421007651 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 710421007652 shikimate binding site; other site 710421007653 NAD(P) binding site [chemical binding]; other site 710421007654 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 710421007655 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 710421007656 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 710421007657 Tetramer interface [polypeptide binding]; other site 710421007658 active site 710421007659 FMN-binding site [chemical binding]; other site 710421007660 shikimate kinase; Reviewed; Region: aroK; PRK00131 710421007661 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 710421007662 ADP binding site [chemical binding]; other site 710421007663 magnesium binding site [ion binding]; other site 710421007664 putative shikimate binding site; other site 710421007665 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 710421007666 active site 710421007667 dimer interface [polypeptide binding]; other site 710421007668 metal binding site [ion binding]; metal-binding site 710421007669 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710421007670 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710421007671 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 710421007672 active site 710421007673 elongation factor P; Validated; Region: PRK00529 710421007674 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 710421007675 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 710421007676 RNA binding site [nucleotide binding]; other site 710421007677 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 710421007678 RNA binding site [nucleotide binding]; other site 710421007679 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 710421007680 putative RNA binding site [nucleotide binding]; other site 710421007681 hypothetical protein; Provisional; Region: PRK07236 710421007682 hypothetical protein; Validated; Region: PRK05868 710421007683 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421007684 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421007685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421007686 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421007687 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421007688 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421007689 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 710421007690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421007691 active site 710421007692 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 710421007693 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710421007694 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710421007695 dihydroorotase; Validated; Region: pyrC; PRK09357 710421007696 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421007697 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 710421007698 active site 710421007699 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 710421007700 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 710421007701 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 710421007702 catalytic site [active] 710421007703 subunit interface [polypeptide binding]; other site 710421007704 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 710421007705 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421007706 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421007707 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 710421007708 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421007709 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421007710 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 710421007711 IMP binding site; other site 710421007712 dimer interface [polypeptide binding]; other site 710421007713 interdomain contacts; other site 710421007714 partial ornithine binding site; other site 710421007715 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 710421007716 active site 710421007717 dimer interface [polypeptide binding]; other site 710421007718 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 710421007719 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 710421007720 catalytic site [active] 710421007721 G-X2-G-X-G-K; other site 710421007722 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 710421007723 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 710421007724 Flavoprotein; Region: Flavoprotein; pfam02441 710421007725 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 710421007726 S-adenosylmethionine synthetase; Validated; Region: PRK05250 710421007727 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 710421007728 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 710421007729 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 710421007730 YhhN-like protein; Region: YhhN; pfam07947 710421007731 primosome assembly protein PriA; Provisional; Region: PRK14873 710421007732 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 710421007733 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 710421007734 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 710421007735 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 710421007736 putative active site [active] 710421007737 substrate binding site [chemical binding]; other site 710421007738 putative cosubstrate binding site; other site 710421007739 catalytic site [active] 710421007740 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 710421007741 substrate binding site [chemical binding]; other site 710421007742 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 710421007743 putative RNA binding site [nucleotide binding]; other site 710421007744 16S rRNA methyltransferase B; Provisional; Region: PRK14902 710421007745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421007746 S-adenosylmethionine binding site [chemical binding]; other site 710421007747 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 710421007748 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 710421007749 substrate binding site [chemical binding]; other site 710421007750 hexamer interface [polypeptide binding]; other site 710421007751 metal binding site [ion binding]; metal-binding site 710421007752 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 710421007753 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 710421007754 catalytic motif [active] 710421007755 Zn binding site [ion binding]; other site 710421007756 RibD C-terminal domain; Region: RibD_C; pfam01872 710421007757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421007758 putative substrate translocation pore; other site 710421007759 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 710421007760 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 710421007761 Lumazine binding domain; Region: Lum_binding; pfam00677 710421007762 Lumazine binding domain; Region: Lum_binding; pfam00677 710421007763 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 710421007764 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 710421007765 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710421007766 dimerization interface [polypeptide binding]; other site 710421007767 active site 710421007768 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 710421007769 homopentamer interface [polypeptide binding]; other site 710421007770 active site 710421007771 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 710421007772 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 710421007773 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710421007774 GIY-YIG motif/motif A; other site 710421007775 active site 710421007776 catalytic site [active] 710421007777 putative DNA binding site [nucleotide binding]; other site 710421007778 metal binding site [ion binding]; metal-binding site 710421007779 UvrB/uvrC motif; Region: UVR; pfam02151 710421007780 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 710421007781 minor groove reading motif; other site 710421007782 Helix-hairpin-helix motif; Region: HHH; pfam00633 710421007783 helix-hairpin-helix signature motif; other site 710421007784 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 710421007785 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 710421007786 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 710421007787 phosphate binding site [ion binding]; other site 710421007788 putative substrate binding pocket [chemical binding]; other site 710421007789 dimer interface [polypeptide binding]; other site 710421007790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 710421007791 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 710421007792 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421007793 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421007794 substrate binding pocket [chemical binding]; other site 710421007795 membrane-bound complex binding site; other site 710421007796 hinge residues; other site 710421007797 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 710421007798 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 710421007799 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710421007800 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 710421007801 Phosphoglycerate kinase; Region: PGK; pfam00162 710421007802 substrate binding site [chemical binding]; other site 710421007803 hinge regions; other site 710421007804 ADP binding site [chemical binding]; other site 710421007805 catalytic site [active] 710421007806 triosephosphate isomerase; Provisional; Region: PRK14567 710421007807 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 710421007808 substrate binding site [chemical binding]; other site 710421007809 dimer interface [polypeptide binding]; other site 710421007810 catalytic triad [active] 710421007811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421007812 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 710421007813 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 710421007814 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 710421007815 Cysteine-rich domain; Region: CCG; pfam02754 710421007816 Cysteine-rich domain; Region: CCG; pfam02754 710421007817 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 710421007818 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 710421007819 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 710421007820 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 710421007821 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 710421007822 putative active site [active] 710421007823 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 710421007824 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 710421007825 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 710421007826 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710421007827 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 710421007828 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 710421007829 putative active site [active] 710421007830 transaldolase; Provisional; Region: PRK03903 710421007831 catalytic residue [active] 710421007832 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 710421007833 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 710421007834 TPP-binding site [chemical binding]; other site 710421007835 dimer interface [polypeptide binding]; other site 710421007836 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710421007837 PYR/PP interface [polypeptide binding]; other site 710421007838 dimer interface [polypeptide binding]; other site 710421007839 TPP binding site [chemical binding]; other site 710421007840 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710421007841 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 710421007842 UbiA prenyltransferase family; Region: UbiA; pfam01040 710421007843 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 710421007844 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 710421007845 NADP binding site [chemical binding]; other site 710421007846 dimer interface [polypeptide binding]; other site 710421007847 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 710421007848 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 710421007849 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710421007850 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710421007851 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710421007852 Walker A/P-loop; other site 710421007853 ATP binding site [chemical binding]; other site 710421007854 Q-loop/lid; other site 710421007855 ABC transporter signature motif; other site 710421007856 Walker B; other site 710421007857 D-loop; other site 710421007858 H-loop/switch region; other site 710421007859 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 710421007860 Predicted transcriptional regulator [Transcription]; Region: COG2345 710421007861 Transcriptional regulator PadR-like family; Region: PadR; cl17335 710421007862 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 710421007863 FeS assembly protein SufB; Region: sufB; TIGR01980 710421007864 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 710421007865 FeS assembly protein SufD; Region: sufD; TIGR01981 710421007866 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 710421007867 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 710421007868 Walker A/P-loop; other site 710421007869 ATP binding site [chemical binding]; other site 710421007870 Q-loop/lid; other site 710421007871 ABC transporter signature motif; other site 710421007872 Walker B; other site 710421007873 D-loop; other site 710421007874 H-loop/switch region; other site 710421007875 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710421007876 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 710421007877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421007878 catalytic residue [active] 710421007879 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 710421007880 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 710421007881 trimerization site [polypeptide binding]; other site 710421007882 active site 710421007883 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 710421007884 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710421007885 catalytic residues [active] 710421007886 enoyl-CoA hydratase; Provisional; Region: PRK05864 710421007887 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421007888 substrate binding site [chemical binding]; other site 710421007889 oxyanion hole (OAH) forming residues; other site 710421007890 trimer interface [polypeptide binding]; other site 710421007891 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710421007892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421007893 Walker A/P-loop; other site 710421007894 ATP binding site [chemical binding]; other site 710421007895 Q-loop/lid; other site 710421007896 ABC transporter signature motif; other site 710421007897 Walker B; other site 710421007898 D-loop; other site 710421007899 H-loop/switch region; other site 710421007900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710421007901 PE-PPE domain; Region: PE-PPE; pfam08237 710421007902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421007903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421007904 aconitate hydratase; Validated; Region: PRK09277 710421007905 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 710421007906 substrate binding site [chemical binding]; other site 710421007907 ligand binding site [chemical binding]; other site 710421007908 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 710421007909 substrate binding site [chemical binding]; other site 710421007910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 710421007911 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421007912 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421007913 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421007914 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421007915 MoxR-like ATPases [General function prediction only]; Region: COG0714 710421007916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421007917 Walker A motif; other site 710421007918 ATP binding site [chemical binding]; other site 710421007919 Walker B motif; other site 710421007920 arginine finger; other site 710421007921 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710421007922 Protein of unknown function DUF58; Region: DUF58; pfam01882 710421007923 hypothetical protein; Provisional; Region: PRK13685 710421007924 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 710421007925 von Willebrand factor type A domain; Region: VWA_2; pfam13519 710421007926 metal ion-dependent adhesion site (MIDAS); other site 710421007927 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 710421007928 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 710421007929 NAD(P) binding site [chemical binding]; other site 710421007930 homotetramer interface [polypeptide binding]; other site 710421007931 homodimer interface [polypeptide binding]; other site 710421007932 active site 710421007933 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 710421007934 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 710421007935 NAD binding site [chemical binding]; other site 710421007936 homotetramer interface [polypeptide binding]; other site 710421007937 homodimer interface [polypeptide binding]; other site 710421007938 substrate binding site [chemical binding]; other site 710421007939 active site 710421007940 ferrochelatase; Reviewed; Region: hemH; PRK00035 710421007941 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 710421007942 C-terminal domain interface [polypeptide binding]; other site 710421007943 active site 710421007944 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 710421007945 active site 710421007946 N-terminal domain interface [polypeptide binding]; other site 710421007947 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 710421007948 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 710421007949 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 710421007950 Uncharacterized conserved protein [Function unknown]; Region: COG0398 710421007951 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 710421007952 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 710421007953 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 710421007954 heterodimer interface [polypeptide binding]; other site 710421007955 substrate interaction site [chemical binding]; other site 710421007956 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 710421007957 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 710421007958 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 710421007959 active site 710421007960 substrate binding site [chemical binding]; other site 710421007961 coenzyme B12 binding site [chemical binding]; other site 710421007962 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710421007963 B12 binding site [chemical binding]; other site 710421007964 cobalt ligand [ion binding]; other site 710421007965 membrane ATPase/protein kinase; Provisional; Region: PRK09435 710421007966 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 710421007967 Walker A; other site 710421007968 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421007969 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421007970 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 710421007971 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421007972 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421007973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421007974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421007975 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421007976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421007977 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421007978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421007979 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710421007980 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710421007981 NAD binding site [chemical binding]; other site 710421007982 catalytic Zn binding site [ion binding]; other site 710421007983 substrate binding site [chemical binding]; other site 710421007984 structural Zn binding site [ion binding]; other site 710421007985 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710421007986 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710421007987 NAD binding site [chemical binding]; other site 710421007988 catalytic residues [active] 710421007989 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 710421007990 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710421007991 HIGH motif; other site 710421007992 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710421007993 active site 710421007994 KMSKS motif; other site 710421007995 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 710421007996 tRNA binding surface [nucleotide binding]; other site 710421007997 anticodon binding site; other site 710421007998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710421007999 RNA binding surface [nucleotide binding]; other site 710421008000 DNA polymerase IV; Provisional; Region: PRK03348 710421008001 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710421008002 active site 710421008003 DNA binding site [nucleotide binding] 710421008004 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 710421008005 active site 710421008006 homodimer interface [polypeptide binding]; other site 710421008007 lipoprotein signal peptidase; Provisional; Region: PRK14764 710421008008 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 710421008009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710421008010 RNA binding surface [nucleotide binding]; other site 710421008011 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 710421008012 active site 710421008013 Predicted permeases [General function prediction only]; Region: RarD; COG2962 710421008014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421008015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421008016 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 710421008017 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 710421008018 active site 710421008019 PHP Thumb interface [polypeptide binding]; other site 710421008020 metal binding site [ion binding]; metal-binding site 710421008021 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 710421008022 generic binding surface II; other site 710421008023 generic binding surface I; other site 710421008024 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710421008025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421008026 Walker A/P-loop; other site 710421008027 ATP binding site [chemical binding]; other site 710421008028 Q-loop/lid; other site 710421008029 ABC transporter signature motif; other site 710421008030 Walker B; other site 710421008031 D-loop; other site 710421008032 H-loop/switch region; other site 710421008033 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710421008034 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421008035 Cadmium resistance transporter; Region: Cad; pfam03596 710421008036 threonine dehydratase; Validated; Region: PRK08639 710421008037 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710421008038 tetramer interface [polypeptide binding]; other site 710421008039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421008040 catalytic residue [active] 710421008041 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 710421008042 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 710421008043 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 710421008044 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 710421008045 catalytic site [active] 710421008046 active site 710421008047 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710421008048 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 710421008049 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 710421008050 active site 710421008051 catalytic site [active] 710421008052 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710421008053 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710421008054 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710421008055 active site 710421008056 catalytic site [active] 710421008057 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710421008058 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710421008059 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 710421008060 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421008061 inhibitor-cofactor binding pocket; inhibition site 710421008062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421008063 catalytic residue [active] 710421008064 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 710421008065 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 710421008066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421008067 catalytic residue [active] 710421008068 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 710421008069 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710421008070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421008071 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 710421008072 biotin synthase; Validated; Region: PRK06256 710421008073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421008074 FeS/SAM binding site; other site 710421008075 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 710421008076 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 710421008077 Secretory lipase; Region: LIP; pfam03583 710421008078 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 710421008079 nudix motif; other site 710421008080 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 710421008081 quinolinate synthetase; Provisional; Region: PRK09375 710421008082 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 710421008083 L-aspartate oxidase; Provisional; Region: PRK06175 710421008084 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 710421008085 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 710421008086 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 710421008087 dimerization interface [polypeptide binding]; other site 710421008088 active site 710421008089 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421008090 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 710421008091 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 710421008092 NAD binding site [chemical binding]; other site 710421008093 dimerization interface [polypeptide binding]; other site 710421008094 product binding site; other site 710421008095 substrate binding site [chemical binding]; other site 710421008096 zinc binding site [ion binding]; other site 710421008097 catalytic residues [active] 710421008098 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 710421008099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421008100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421008101 homodimer interface [polypeptide binding]; other site 710421008102 catalytic residue [active] 710421008103 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 710421008104 putative active site pocket [active] 710421008105 4-fold oligomerization interface [polypeptide binding]; other site 710421008106 metal binding residues [ion binding]; metal-binding site 710421008107 3-fold/trimer interface [polypeptide binding]; other site 710421008108 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 710421008109 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 710421008110 putative active site [active] 710421008111 oxyanion strand; other site 710421008112 catalytic triad [active] 710421008113 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 710421008114 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710421008115 catalytic residues [active] 710421008116 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 710421008117 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 710421008118 active site 710421008119 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 710421008120 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 710421008121 substrate binding site [chemical binding]; other site 710421008122 glutamase interaction surface [polypeptide binding]; other site 710421008123 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 710421008124 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 710421008125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421008126 Walker A/P-loop; other site 710421008127 ATP binding site [chemical binding]; other site 710421008128 Q-loop/lid; other site 710421008129 ABC transporter signature motif; other site 710421008130 Walker B; other site 710421008131 D-loop; other site 710421008132 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710421008133 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710421008134 catalytic triad [active] 710421008135 anthranilate synthase component I; Provisional; Region: PRK13571 710421008136 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 710421008137 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 710421008138 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 710421008139 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 710421008140 active site 710421008141 ribulose/triose binding site [chemical binding]; other site 710421008142 phosphate binding site [ion binding]; other site 710421008143 substrate (anthranilate) binding pocket [chemical binding]; other site 710421008144 product (indole) binding pocket [chemical binding]; other site 710421008145 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 710421008146 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 710421008147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421008148 catalytic residue [active] 710421008149 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 710421008150 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 710421008151 substrate binding site [chemical binding]; other site 710421008152 active site 710421008153 catalytic residues [active] 710421008154 heterodimer interface [polypeptide binding]; other site 710421008155 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 710421008156 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421008157 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421008158 active site 710421008159 TM2 domain; Region: TM2; pfam05154 710421008160 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 710421008161 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 710421008162 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 710421008163 active site 710421008164 dimer interface [polypeptide binding]; other site 710421008165 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 710421008166 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710421008167 active site 710421008168 FMN binding site [chemical binding]; other site 710421008169 substrate binding site [chemical binding]; other site 710421008170 3Fe-4S cluster binding site [ion binding]; other site 710421008171 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 710421008172 domain interface; other site 710421008173 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 710421008174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421008175 pyruvate kinase; Provisional; Region: PRK06247 710421008176 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 710421008177 domain interfaces; other site 710421008178 active site 710421008179 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710421008180 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710421008181 active site 710421008182 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710421008183 catalytic triad [active] 710421008184 dimer interface [polypeptide binding]; other site 710421008185 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 710421008186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421008187 Walker A/P-loop; other site 710421008188 ATP binding site [chemical binding]; other site 710421008189 Q-loop/lid; other site 710421008190 ABC transporter signature motif; other site 710421008191 Walker B; other site 710421008192 D-loop; other site 710421008193 H-loop/switch region; other site 710421008194 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 710421008195 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710421008196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421008197 Walker A/P-loop; other site 710421008198 ATP binding site [chemical binding]; other site 710421008199 Q-loop/lid; other site 710421008200 ABC transporter signature motif; other site 710421008201 Walker B; other site 710421008202 D-loop; other site 710421008203 H-loop/switch region; other site 710421008204 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 710421008205 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 710421008206 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 710421008207 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 710421008208 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 710421008209 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 710421008210 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421008211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421008212 substrate binding pocket [chemical binding]; other site 710421008213 membrane-bound complex binding site; other site 710421008214 hinge residues; other site 710421008215 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710421008216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421008217 dimer interface [polypeptide binding]; other site 710421008218 conserved gate region; other site 710421008219 putative PBP binding loops; other site 710421008220 ABC-ATPase subunit interface; other site 710421008221 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710421008222 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710421008223 Walker A/P-loop; other site 710421008224 ATP binding site [chemical binding]; other site 710421008225 Q-loop/lid; other site 710421008226 ABC transporter signature motif; other site 710421008227 Walker B; other site 710421008228 D-loop; other site 710421008229 H-loop/switch region; other site 710421008230 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710421008231 Ferritin-like domain; Region: Ferritin; pfam00210 710421008232 dimerization interface [polypeptide binding]; other site 710421008233 DPS ferroxidase diiron center [ion binding]; other site 710421008234 ion pore; other site 710421008235 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710421008236 cyclase homology domain; Region: CHD; cd07302 710421008237 nucleotidyl binding site; other site 710421008238 metal binding site [ion binding]; metal-binding site 710421008239 dimer interface [polypeptide binding]; other site 710421008240 Predicted amidohydrolase [General function prediction only]; Region: COG0388 710421008241 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 710421008242 active site 710421008243 catalytic triad [active] 710421008244 dimer interface [polypeptide binding]; other site 710421008245 PE-PPE domain; Region: PE-PPE; pfam08237 710421008246 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710421008247 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 710421008248 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421008249 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421008250 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 710421008251 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 710421008252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421008253 active site 710421008254 phosphorylation site [posttranslational modification] 710421008255 intermolecular recognition site; other site 710421008256 dimerization interface [polypeptide binding]; other site 710421008257 ANTAR domain; Region: ANTAR; pfam03861 710421008258 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 710421008259 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 710421008260 dimerization interface [polypeptide binding]; other site 710421008261 ligand binding site [chemical binding]; other site 710421008262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710421008263 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 710421008264 TM-ABC transporter signature motif; other site 710421008265 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 710421008266 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 710421008267 TM-ABC transporter signature motif; other site 710421008268 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 710421008269 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 710421008270 Walker A/P-loop; other site 710421008271 ATP binding site [chemical binding]; other site 710421008272 Q-loop/lid; other site 710421008273 ABC transporter signature motif; other site 710421008274 Walker B; other site 710421008275 D-loop; other site 710421008276 H-loop/switch region; other site 710421008277 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 710421008278 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 710421008279 Walker A/P-loop; other site 710421008280 ATP binding site [chemical binding]; other site 710421008281 Q-loop/lid; other site 710421008282 ABC transporter signature motif; other site 710421008283 Walker B; other site 710421008284 D-loop; other site 710421008285 H-loop/switch region; other site 710421008286 lipid-transfer protein; Provisional; Region: PRK06059 710421008287 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421008288 active site 710421008289 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710421008290 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710421008291 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421008292 DNA polymerase I; Provisional; Region: PRK05755 710421008293 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710421008294 active site 710421008295 metal binding site 1 [ion binding]; metal-binding site 710421008296 putative 5' ssDNA interaction site; other site 710421008297 metal binding site 3; metal-binding site 710421008298 metal binding site 2 [ion binding]; metal-binding site 710421008299 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710421008300 putative DNA binding site [nucleotide binding]; other site 710421008301 putative metal binding site [ion binding]; other site 710421008302 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 710421008303 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 710421008304 active site 710421008305 DNA binding site [nucleotide binding] 710421008306 catalytic site [active] 710421008307 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710421008308 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 710421008309 active site 710421008310 dimer interface [polypeptide binding]; other site 710421008311 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710421008312 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 710421008313 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 710421008314 RNA binding site [nucleotide binding]; other site 710421008315 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 710421008316 RNA binding site [nucleotide binding]; other site 710421008317 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710421008318 RNA binding site [nucleotide binding]; other site 710421008319 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 710421008320 RNA binding site [nucleotide binding]; other site 710421008321 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 710421008322 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 710421008323 CoA-binding site [chemical binding]; other site 710421008324 ATP-binding [chemical binding]; other site 710421008325 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 710421008326 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 710421008327 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 710421008328 DNA binding residues [nucleotide binding] 710421008329 dimer interface [polypeptide binding]; other site 710421008330 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 710421008331 Protein of unknown function (DUF402); Region: DUF402; cl00979 710421008332 excinuclease ABC subunit B; Provisional; Region: PRK05298 710421008333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421008334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421008335 nucleotide binding region [chemical binding]; other site 710421008336 ATP-binding site [chemical binding]; other site 710421008337 Ultra-violet resistance protein B; Region: UvrB; pfam12344 710421008338 UvrB/uvrC motif; Region: UVR; pfam02151 710421008339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421008340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421008341 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 710421008342 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 710421008343 Cutinase; Region: Cutinase; pfam01083 710421008344 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421008345 Ligand Binding Site [chemical binding]; other site 710421008346 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 710421008347 catalytic residue [active] 710421008348 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421008349 Cytochrome P450; Region: p450; cl12078 710421008350 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710421008351 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 710421008352 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710421008353 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710421008354 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 710421008355 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 710421008356 Winged helix-turn helix; Region: HTH_29; pfam13551 710421008357 Integrase core domain; Region: rve; pfam00665 710421008358 Integrase core domain; Region: rve_3; pfam13683 710421008359 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 710421008360 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 710421008361 Predicted esterase [General function prediction only]; Region: COG0627 710421008362 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 710421008363 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 710421008364 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 710421008365 dimer interface [polypeptide binding]; other site 710421008366 putative anticodon binding site; other site 710421008367 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710421008368 motif 1; other site 710421008369 dimer interface [polypeptide binding]; other site 710421008370 active site 710421008371 motif 2; other site 710421008372 motif 3; other site 710421008373 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 710421008374 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 710421008375 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 710421008376 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 710421008377 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 710421008378 23S rRNA binding site [nucleotide binding]; other site 710421008379 L21 binding site [polypeptide binding]; other site 710421008380 L13 binding site [polypeptide binding]; other site 710421008381 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710421008382 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 710421008383 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710421008384 PE-PPE domain; Region: PE-PPE; pfam08237 710421008385 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421008386 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421008387 active site 710421008388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 710421008389 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421008390 cyclase homology domain; Region: CHD; cd07302 710421008391 nucleotidyl binding site; other site 710421008392 metal binding site [ion binding]; metal-binding site 710421008393 dimer interface [polypeptide binding]; other site 710421008394 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 710421008395 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 710421008396 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 710421008397 dimer interface [polypeptide binding]; other site 710421008398 motif 1; other site 710421008399 active site 710421008400 motif 2; other site 710421008401 motif 3; other site 710421008402 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 710421008403 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710421008404 putative tRNA-binding site [nucleotide binding]; other site 710421008405 B3/4 domain; Region: B3_4; pfam03483 710421008406 tRNA synthetase B5 domain; Region: B5; smart00874 710421008407 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 710421008408 dimer interface [polypeptide binding]; other site 710421008409 motif 1; other site 710421008410 motif 3; other site 710421008411 motif 2; other site 710421008412 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 710421008413 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 710421008414 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710421008415 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 710421008416 heterotetramer interface [polypeptide binding]; other site 710421008417 active site pocket [active] 710421008418 cleavage site 710421008419 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 710421008420 feedback inhibition sensing region; other site 710421008421 homohexameric interface [polypeptide binding]; other site 710421008422 nucleotide binding site [chemical binding]; other site 710421008423 N-acetyl-L-glutamate binding site [chemical binding]; other site 710421008424 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 710421008425 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421008426 inhibitor-cofactor binding pocket; inhibition site 710421008427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421008428 catalytic residue [active] 710421008429 ornithine carbamoyltransferase; Provisional; Region: PRK00779 710421008430 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 710421008431 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 710421008432 arginine repressor; Provisional; Region: PRK03341 710421008433 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 710421008434 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 710421008435 argininosuccinate synthase; Provisional; Region: PRK13820 710421008436 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 710421008437 ANP binding site [chemical binding]; other site 710421008438 Substrate Binding Site II [chemical binding]; other site 710421008439 Substrate Binding Site I [chemical binding]; other site 710421008440 argininosuccinate lyase; Provisional; Region: PRK00855 710421008441 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 710421008442 active sites [active] 710421008443 tetramer interface [polypeptide binding]; other site 710421008444 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710421008445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710421008446 ABC transporter; Region: ABC_tran_2; pfam12848 710421008447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710421008448 acyl-CoA synthetase; Validated; Region: PRK07868 710421008449 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 710421008450 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421008451 acyl-activating enzyme (AAE) consensus motif; other site 710421008452 AMP binding site [chemical binding]; other site 710421008453 active site 710421008454 CoA binding site [chemical binding]; other site 710421008455 Uncharacterized conserved protein [Function unknown]; Region: COG2835 710421008456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421008457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421008458 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710421008459 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421008460 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710421008461 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710421008462 Walker A/P-loop; other site 710421008463 ATP binding site [chemical binding]; other site 710421008464 Q-loop/lid; other site 710421008465 ABC transporter signature motif; other site 710421008466 Walker B; other site 710421008467 D-loop; other site 710421008468 H-loop/switch region; other site 710421008469 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421008470 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 710421008471 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 710421008472 active site 710421008473 DNA binding site [nucleotide binding] 710421008474 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 710421008475 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 710421008476 active site 710421008477 HIGH motif; other site 710421008478 dimer interface [polypeptide binding]; other site 710421008479 KMSKS motif; other site 710421008480 S4 RNA-binding domain; Region: S4; smart00363 710421008481 RNA binding surface [nucleotide binding]; other site 710421008482 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 710421008483 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 710421008484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421008485 active site 710421008486 motif I; other site 710421008487 motif II; other site 710421008488 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 710421008489 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 710421008490 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710421008491 RNA binding surface [nucleotide binding]; other site 710421008492 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 710421008493 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 710421008494 ATP-NAD kinase; Region: NAD_kinase; pfam01513 710421008495 DNA repair protein RecN; Region: recN; TIGR00634 710421008496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421008497 Walker A/P-loop; other site 710421008498 ATP binding site [chemical binding]; other site 710421008499 Q-loop/lid; other site 710421008500 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 710421008501 ABC transporter signature motif; other site 710421008502 Walker B; other site 710421008503 D-loop; other site 710421008504 H-loop/switch region; other site 710421008505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421008506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421008507 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 710421008508 Thiamine pyrophosphokinase; Region: TPK; cl08415 710421008509 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 710421008510 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 710421008511 CTP synthetase; Validated; Region: pyrG; PRK05380 710421008512 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 710421008513 Catalytic site [active] 710421008514 active site 710421008515 UTP binding site [chemical binding]; other site 710421008516 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 710421008517 active site 710421008518 putative oxyanion hole; other site 710421008519 catalytic triad [active] 710421008520 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 710421008521 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710421008522 dimer interface [polypeptide binding]; other site 710421008523 active site 710421008524 ADP-ribose binding site [chemical binding]; other site 710421008525 nudix motif; other site 710421008526 metal binding site [ion binding]; metal-binding site 710421008527 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 710421008528 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 710421008529 active site 710421008530 DNA binding site [nucleotide binding] 710421008531 Int/Topo IB signature motif; other site 710421008532 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710421008533 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421008534 P-loop; other site 710421008535 Magnesium ion binding site [ion binding]; other site 710421008536 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421008537 Magnesium ion binding site [ion binding]; other site 710421008538 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 710421008539 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 710421008540 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 710421008541 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710421008542 RNA binding surface [nucleotide binding]; other site 710421008543 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 710421008544 active site 710421008545 cytidylate kinase; Provisional; Region: cmk; PRK00023 710421008546 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 710421008547 CMP-binding site; other site 710421008548 The sites determining sugar specificity; other site 710421008549 GTP-binding protein Der; Reviewed; Region: PRK03003 710421008550 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 710421008551 G1 box; other site 710421008552 GTP/Mg2+ binding site [chemical binding]; other site 710421008553 Switch I region; other site 710421008554 G2 box; other site 710421008555 Switch II region; other site 710421008556 G3 box; other site 710421008557 G4 box; other site 710421008558 G5 box; other site 710421008559 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 710421008560 G1 box; other site 710421008561 GTP/Mg2+ binding site [chemical binding]; other site 710421008562 Switch I region; other site 710421008563 G2 box; other site 710421008564 G3 box; other site 710421008565 Switch II region; other site 710421008566 G4 box; other site 710421008567 G5 box; other site 710421008568 hypothetical protein; Provisional; Region: PRK10621 710421008569 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710421008570 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 710421008571 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 710421008572 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 710421008573 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 710421008574 Methyltransferase domain; Region: Methyltransf_26; pfam13659 710421008575 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 710421008576 Winged helix-turn helix; Region: HTH_29; pfam13551 710421008577 Integrase core domain; Region: rve; pfam00665 710421008578 Integrase core domain; Region: rve_3; pfam13683 710421008579 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421008580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421008581 non-specific DNA binding site [nucleotide binding]; other site 710421008582 salt bridge; other site 710421008583 sequence-specific DNA binding site [nucleotide binding]; other site 710421008584 Domain of unknown function (DUF955); Region: DUF955; cl01076 710421008585 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 710421008586 AAA domain; Region: AAA_25; pfam13481 710421008587 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710421008588 Walker A motif; other site 710421008589 ATP binding site [chemical binding]; other site 710421008590 Walker B motif; other site 710421008591 Helix-turn-helix domain; Region: HTH_17; cl17695 710421008592 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 710421008593 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 710421008594 active site 710421008595 catalytic residues [active] 710421008596 DNA binding site [nucleotide binding] 710421008597 Int/Topo IB signature motif; other site 710421008598 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421008599 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 710421008600 Short C-terminal domain; Region: SHOCT; pfam09851 710421008601 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 710421008602 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421008603 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710421008604 cyclase homology domain; Region: CHD; cd07302 710421008605 nucleotidyl binding site; other site 710421008606 metal binding site [ion binding]; metal-binding site 710421008607 dimer interface [polypeptide binding]; other site 710421008608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 710421008609 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 710421008610 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 710421008611 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710421008612 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710421008613 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 710421008614 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 710421008615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421008616 dimerization interface [polypeptide binding]; other site 710421008617 putative DNA binding site [nucleotide binding]; other site 710421008618 putative Zn2+ binding site [ion binding]; other site 710421008619 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421008620 active site residue [active] 710421008621 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421008622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421008623 putative substrate translocation pore; other site 710421008624 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421008625 anti sigma factor interaction site; other site 710421008626 regulatory phosphorylation site [posttranslational modification]; other site 710421008627 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710421008628 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710421008629 active site 710421008630 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710421008631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421008632 Cupin domain; Region: Cupin_2; cl17218 710421008633 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 710421008634 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 710421008635 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710421008636 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710421008637 metal binding site 2 [ion binding]; metal-binding site 710421008638 putative DNA binding helix; other site 710421008639 metal binding site 1 [ion binding]; metal-binding site 710421008640 dimer interface [polypeptide binding]; other site 710421008641 structural Zn2+ binding site [ion binding]; other site 710421008642 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 710421008643 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 710421008644 heme binding site [chemical binding]; other site 710421008645 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 710421008646 CheB methylesterase; Region: CheB_methylest; pfam01339 710421008647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421008648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 710421008649 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 710421008650 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710421008651 PhoU domain; Region: PhoU; pfam01895 710421008652 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 710421008653 Winged helix-turn helix; Region: HTH_29; pfam13551 710421008654 Integrase core domain; Region: rve; pfam00665 710421008655 Integrase core domain; Region: rve_3; pfam13683 710421008656 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 710421008657 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 710421008658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421008659 S-adenosylmethionine binding site [chemical binding]; other site 710421008660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710421008661 PAS domain; Region: PAS_9; pfam13426 710421008662 putative active site [active] 710421008663 heme pocket [chemical binding]; other site 710421008664 PAS domain; Region: PAS_9; pfam13426 710421008665 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 710421008666 Fe-S cluster binding site [ion binding]; other site 710421008667 active site 710421008668 PAS fold; Region: PAS_3; pfam08447 710421008669 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710421008670 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 710421008671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421008672 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710421008673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421008674 DNA binding residues [nucleotide binding] 710421008675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421008676 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421008677 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 710421008678 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 710421008679 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 710421008680 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710421008681 RNA binding site [nucleotide binding]; other site 710421008682 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 710421008683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421008684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421008685 active site 710421008686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421008687 S-adenosylmethionine binding site [chemical binding]; other site 710421008688 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710421008689 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421008690 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710421008691 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421008692 Cytochrome P450; Region: p450; cl12078 710421008693 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 710421008694 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 710421008695 active site 710421008696 catalytic triad [active] 710421008697 oxyanion hole [active] 710421008698 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 710421008699 nudix motif; other site 710421008700 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710421008701 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 710421008702 FMN-binding pocket [chemical binding]; other site 710421008703 flavin binding motif; other site 710421008704 phosphate binding motif [ion binding]; other site 710421008705 beta-alpha-beta structure motif; other site 710421008706 NAD binding pocket [chemical binding]; other site 710421008707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421008708 catalytic loop [active] 710421008709 iron binding site [ion binding]; other site 710421008710 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 710421008711 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 710421008712 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 710421008713 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 710421008714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421008715 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710421008716 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421008717 substrate binding pocket [chemical binding]; other site 710421008718 catalytic triad [active] 710421008719 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 710421008720 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 710421008721 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710421008722 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710421008723 Domain of unknown function (DUF385); Region: DUF385; cl04387 710421008724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421008725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421008726 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 710421008727 active site 710421008728 metal binding site [ion binding]; metal-binding site 710421008729 hypothetical protein; Validated; Region: PRK07121 710421008730 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421008731 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421008732 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421008733 active site 710421008734 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 710421008735 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 710421008736 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 710421008737 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 710421008738 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 710421008739 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 710421008740 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 710421008741 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 710421008742 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 710421008743 nucleotide binding region [chemical binding]; other site 710421008744 ATP-binding site [chemical binding]; other site 710421008745 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 710421008746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710421008747 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710421008748 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 710421008749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 710421008750 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 710421008751 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 710421008752 lipoyl attachment site [posttranslational modification]; other site 710421008753 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710421008754 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421008755 phosphopeptide binding site; other site 710421008756 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 710421008757 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710421008758 DNA binding residues [nucleotide binding] 710421008759 Bifunctional nuclease; Region: DNase-RNase; pfam02577 710421008760 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 710421008761 DNA binding residues [nucleotide binding] 710421008762 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710421008763 putative dimer interface [polypeptide binding]; other site 710421008764 glycine dehydrogenase; Provisional; Region: PRK05367 710421008765 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710421008766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421008767 tetramer interface [polypeptide binding]; other site 710421008768 catalytic residue [active] 710421008769 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 710421008770 tetramer interface [polypeptide binding]; other site 710421008771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421008772 catalytic residue [active] 710421008773 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 710421008774 acyl-CoA synthetase; Validated; Region: PRK05850 710421008775 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710421008776 acyl-activating enzyme (AAE) consensus motif; other site 710421008777 active site 710421008778 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421008779 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421008780 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710421008781 active site 710421008782 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710421008783 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421008784 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 710421008785 KR domain; Region: KR; pfam08659 710421008786 NADP binding site [chemical binding]; other site 710421008787 active site 710421008788 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421008789 acyl-CoA synthetase; Validated; Region: PRK05850 710421008790 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710421008791 acyl-activating enzyme (AAE) consensus motif; other site 710421008792 active site 710421008793 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421008794 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421008795 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710421008796 active site 710421008797 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710421008798 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421008799 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 710421008800 KR domain; Region: KR; pfam08659 710421008801 NADP binding site [chemical binding]; other site 710421008802 active site 710421008803 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421008804 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710421008805 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421008806 active site 710421008807 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421008808 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710421008809 KR domain; Region: KR; pfam08659 710421008810 putative NADP binding site [chemical binding]; other site 710421008811 active site 710421008812 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421008813 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710421008814 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421008815 active site 710421008816 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421008817 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710421008818 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710421008819 KR domain; Region: KR; pfam08659 710421008820 putative NADP binding site [chemical binding]; other site 710421008821 active site 710421008822 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421008823 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710421008824 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421008825 active site 710421008826 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710421008827 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421008828 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421008829 Condensation domain; Region: Condensation; pfam00668 710421008830 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710421008831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421008832 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710421008833 Walker A/P-loop; other site 710421008834 ATP binding site [chemical binding]; other site 710421008835 Q-loop/lid; other site 710421008836 ABC transporter signature motif; other site 710421008837 Walker B; other site 710421008838 D-loop; other site 710421008839 H-loop/switch region; other site 710421008840 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710421008841 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421008842 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710421008843 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421008844 acyltransferase PapA5; Provisional; Region: PRK09294 710421008845 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421008846 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710421008847 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710421008848 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710421008849 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 710421008850 FMN binding site [chemical binding]; other site 710421008851 dimer interface [polypeptide binding]; other site 710421008852 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421008853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421008854 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421008855 Cytochrome P450; Region: p450; cl12078 710421008856 short chain dehydrogenase; Provisional; Region: PRK07825 710421008857 classical (c) SDRs; Region: SDR_c; cd05233 710421008858 NAD(P) binding site [chemical binding]; other site 710421008859 active site 710421008860 classical (c) SDRs; Region: SDR_c; cd05233 710421008861 NAD(P) binding site [chemical binding]; other site 710421008862 active site 710421008863 Cutinase; Region: Cutinase; pfam01083 710421008864 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421008865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421008866 PE-PPE domain; Region: PE-PPE; pfam08237 710421008867 PE-PPE domain; Region: PE-PPE; pfam08237 710421008868 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 710421008869 Fatty acid desaturase; Region: FA_desaturase; pfam00487 710421008870 Di-iron ligands [ion binding]; other site 710421008871 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 710421008872 substrate binding site [chemical binding]; other site 710421008873 homodimer interface [polypeptide binding]; other site 710421008874 heme binding site [chemical binding]; other site 710421008875 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710421008876 metal ion-dependent adhesion site (MIDAS); other site 710421008877 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 710421008878 active site 710421008879 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710421008880 Domain of unknown function DUF21; Region: DUF21; pfam01595 710421008881 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710421008882 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710421008883 Domain of unknown function DUF21; Region: DUF21; pfam01595 710421008884 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710421008885 Transporter associated domain; Region: CorC_HlyC; smart01091 710421008886 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 710421008887 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 710421008888 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710421008889 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 710421008890 active site 710421008891 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421008892 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 710421008893 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 710421008894 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 710421008895 Predicted transcriptional regulator [Transcription]; Region: COG3682 710421008896 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421008897 CoenzymeA binding site [chemical binding]; other site 710421008898 subunit interaction site [polypeptide binding]; other site 710421008899 PHB binding site; other site 710421008900 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 710421008901 alpha-gamma subunit interface [polypeptide binding]; other site 710421008902 beta-gamma subunit interface [polypeptide binding]; other site 710421008903 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 710421008904 gamma-beta subunit interface [polypeptide binding]; other site 710421008905 alpha-beta subunit interface [polypeptide binding]; other site 710421008906 urease subunit alpha; Reviewed; Region: ureC; PRK13206 710421008907 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 710421008908 subunit interactions [polypeptide binding]; other site 710421008909 active site 710421008910 flap region; other site 710421008911 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 710421008912 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710421008913 UreD urease accessory protein; Region: UreD; cl00530 710421008914 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710421008915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421008916 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421008917 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710421008918 short chain dehydrogenase; Provisional; Region: PRK12829 710421008919 classical (c) SDRs; Region: SDR_c; cd05233 710421008920 NAD(P) binding site [chemical binding]; other site 710421008921 active site 710421008922 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 710421008923 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 710421008924 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 710421008925 putative NAD(P) binding site [chemical binding]; other site 710421008926 putative substrate binding site [chemical binding]; other site 710421008927 catalytic Zn binding site [ion binding]; other site 710421008928 structural Zn binding site [ion binding]; other site 710421008929 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 710421008930 CGNR zinc finger; Region: zf-CGNR; pfam11706 710421008931 CAAX protease self-immunity; Region: Abi; pfam02517 710421008932 putative phosphoketolase; Provisional; Region: PRK05261 710421008933 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 710421008934 TPP-binding site; other site 710421008935 Src Homology 3 domain superfamily; Region: SH3; cl17036 710421008936 peptide ligand binding site [polypeptide binding]; other site 710421008937 XFP C-terminal domain; Region: XFP_C; pfam09363 710421008938 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421008939 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421008940 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421008941 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421008942 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 710421008943 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421008944 active site 710421008945 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 710421008946 minor groove reading motif; other site 710421008947 helix-hairpin-helix signature motif; other site 710421008948 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 710421008949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421008950 Walker A motif; other site 710421008951 ATP binding site [chemical binding]; other site 710421008952 Walker B motif; other site 710421008953 arginine finger; other site 710421008954 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710421008955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421008956 short chain dehydrogenase; Provisional; Region: PRK07454 710421008957 NAD(P) binding site [chemical binding]; other site 710421008958 active site 710421008959 Putative esterase; Region: Esterase; pfam00756 710421008960 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710421008961 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710421008962 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710421008963 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710421008964 ligand binding site [chemical binding]; other site 710421008965 flexible hinge region; other site 710421008966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421008967 dimerization interface [polypeptide binding]; other site 710421008968 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421008969 cyclase homology domain; Region: CHD; cd07302 710421008970 nucleotidyl binding site; other site 710421008971 metal binding site [ion binding]; metal-binding site 710421008972 dimer interface [polypeptide binding]; other site 710421008973 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 710421008974 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 710421008975 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710421008976 active site 710421008977 catalytic site [active] 710421008978 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 710421008979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421008980 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710421008981 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421008982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421008983 DNA binding residues [nucleotide binding] 710421008984 dimerization interface [polypeptide binding]; other site 710421008985 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421008986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421008987 DNA binding residues [nucleotide binding] 710421008988 dimerization interface [polypeptide binding]; other site 710421008989 hypothetical protein; Provisional; Region: PRK06184 710421008990 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421008991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421008992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421008993 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421008994 CoenzymeA binding site [chemical binding]; other site 710421008995 subunit interaction site [polypeptide binding]; other site 710421008996 PHB binding site; other site 710421008997 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710421008998 enoyl-CoA hydratase; Provisional; Region: PRK08140 710421008999 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421009000 substrate binding site [chemical binding]; other site 710421009001 oxyanion hole (OAH) forming residues; other site 710421009002 trimer interface [polypeptide binding]; other site 710421009003 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 710421009004 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 710421009005 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 710421009006 heme binding site [chemical binding]; other site 710421009007 ferroxidase pore; other site 710421009008 ferroxidase diiron center [ion binding]; other site 710421009009 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710421009010 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710421009011 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710421009012 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710421009013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421009014 dimerization interface [polypeptide binding]; other site 710421009015 putative DNA binding site [nucleotide binding]; other site 710421009016 putative Zn2+ binding site [ion binding]; other site 710421009017 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 710421009018 putative hydrophobic ligand binding site [chemical binding]; other site 710421009019 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710421009020 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 710421009021 active site 710421009022 putative substrate binding pocket [chemical binding]; other site 710421009023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421009024 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421009025 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 710421009026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421009027 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421009028 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710421009029 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421009030 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421009031 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 710421009032 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421009033 Cytochrome P450; Region: p450; cl12078 710421009034 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421009035 hydrophobic ligand binding site; other site 710421009036 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710421009037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421009038 S-adenosylmethionine binding site [chemical binding]; other site 710421009039 agmatinase; Region: agmatinase; TIGR01230 710421009040 Agmatinase-like family; Region: Agmatinase-like; cd09990 710421009041 active site 710421009042 oligomer interface [polypeptide binding]; other site 710421009043 Mn binding site [ion binding]; other site 710421009044 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710421009045 active site 710421009046 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 710421009047 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 710421009048 tetramer interface [polypeptide binding]; other site 710421009049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421009050 catalytic residue [active] 710421009051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421009052 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710421009053 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421009054 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710421009055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421009056 sequence-specific DNA binding site [nucleotide binding]; other site 710421009057 salt bridge; other site 710421009058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421009059 Cytochrome P450; Region: p450; cl12078 710421009060 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710421009061 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421009062 molybdopterin cofactor binding site; other site 710421009063 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421009064 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710421009065 molybdopterin cofactor binding site; other site 710421009066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421009067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421009068 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421009069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421009070 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421009071 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710421009072 Uncharacterized conserved protein [Function unknown]; Region: COG5649 710421009073 Nitronate monooxygenase; Region: NMO; pfam03060 710421009074 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710421009075 FMN binding site [chemical binding]; other site 710421009076 substrate binding site [chemical binding]; other site 710421009077 putative catalytic residue [active] 710421009078 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710421009079 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710421009080 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421009081 anti sigma factor interaction site; other site 710421009082 regulatory phosphorylation site [posttranslational modification]; other site 710421009083 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710421009084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 710421009085 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421009086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009087 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421009088 NAD(P) binding site [chemical binding]; other site 710421009089 active site 710421009090 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 710421009091 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 710421009092 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 710421009093 competence damage-inducible protein A; Provisional; Region: PRK00549 710421009094 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 710421009095 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 710421009096 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421009097 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710421009098 Amidase; Region: Amidase; cl11426 710421009099 hypothetical protein; Validated; Region: PRK02101 710421009100 NlpC/P60 family; Region: NLPC_P60; cl17555 710421009101 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 710421009102 Response regulator receiver domain; Region: Response_reg; pfam00072 710421009103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421009104 active site 710421009105 phosphorylation site [posttranslational modification] 710421009106 intermolecular recognition site; other site 710421009107 dimerization interface [polypeptide binding]; other site 710421009108 CHASE3 domain; Region: CHASE3; pfam05227 710421009109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421009110 dimer interface [polypeptide binding]; other site 710421009111 phosphorylation site [posttranslational modification] 710421009112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421009113 ATP binding site [chemical binding]; other site 710421009114 Mg2+ binding site [ion binding]; other site 710421009115 G-X-G motif; other site 710421009116 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 710421009117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421009118 active site 710421009119 phosphorylation site [posttranslational modification] 710421009120 intermolecular recognition site; other site 710421009121 dimerization interface [polypeptide binding]; other site 710421009122 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710421009123 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710421009124 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710421009125 active site 710421009126 catalytic triad [active] 710421009127 oxyanion hole [active] 710421009128 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 710421009129 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 710421009130 catalytic triad [active] 710421009131 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 710421009132 substrate binding pocket [chemical binding]; other site 710421009133 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 710421009134 tetramer interface [polypeptide binding]; other site 710421009135 active site 710421009136 Mg2+/Mn2+ binding site [ion binding]; other site 710421009137 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 710421009138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421009139 active site 710421009140 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 710421009141 hypothetical protein; Validated; Region: PRK07198 710421009142 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 710421009143 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 710421009144 dimerization interface [polypeptide binding]; other site 710421009145 active site 710421009146 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 710421009147 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 710421009148 dimer interface [polypeptide binding]; other site 710421009149 catalytic triad [active] 710421009150 peroxidatic and resolving cysteines [active] 710421009151 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421009152 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421009153 PE-PPE domain; Region: PE-PPE; pfam08237 710421009154 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 710421009155 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710421009156 acyl-activating enzyme (AAE) consensus motif; other site 710421009157 active site 710421009158 CAAX protease self-immunity; Region: Abi; pfam02517 710421009159 Uncharacterized conserved protein [Function unknown]; Region: COG1434 710421009160 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 710421009161 putative active site [active] 710421009162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421009163 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710421009164 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 710421009165 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421009166 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421009167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421009168 acyl-activating enzyme (AAE) consensus motif; other site 710421009169 AMP binding site [chemical binding]; other site 710421009170 active site 710421009171 CoA binding site [chemical binding]; other site 710421009172 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 710421009173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421009174 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710421009175 S-adenosylmethionine binding site [chemical binding]; other site 710421009176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710421009177 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710421009178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421009179 S-adenosylmethionine binding site [chemical binding]; other site 710421009180 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 710421009181 S-formylglutathione hydrolase; Region: PLN02442 710421009182 Putative esterase; Region: Esterase; pfam00756 710421009183 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710421009184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421009185 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710421009186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421009187 putative substrate translocation pore; other site 710421009188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421009189 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 710421009190 PknH-like extracellular domain; Region: PknH_C; pfam14032 710421009191 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 710421009192 phosphoglycolate phosphatase, TA0175-type; Region: Pglycolate_arch; TIGR01487 710421009193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421009194 active site 710421009195 motif I; other site 710421009196 motif II; other site 710421009197 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710421009198 Domain of unknown function DUF87; Region: DUF87; pfam01935 710421009199 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 710421009200 tetramer interface [polypeptide binding]; other site 710421009201 dimer interface [polypeptide binding]; other site 710421009202 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710421009203 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421009204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421009205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421009206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421009207 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710421009208 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710421009209 Walker A/P-loop; other site 710421009210 ATP binding site [chemical binding]; other site 710421009211 Q-loop/lid; other site 710421009212 ABC transporter signature motif; other site 710421009213 Walker B; other site 710421009214 D-loop; other site 710421009215 H-loop/switch region; other site 710421009216 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710421009217 substrate binding site [chemical binding]; other site 710421009218 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 710421009219 cyclase homology domain; Region: CHD; cd07302 710421009220 nucleotidyl binding site; other site 710421009221 metal binding site [ion binding]; metal-binding site 710421009222 dimer interface [polypeptide binding]; other site 710421009223 AAA ATPase domain; Region: AAA_16; pfam13191 710421009224 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 710421009225 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 710421009226 putative hydrophobic ligand binding site [chemical binding]; other site 710421009227 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 710421009228 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710421009229 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710421009230 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421009231 acyl-CoA synthetase; Validated; Region: PRK08162 710421009232 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 710421009233 acyl-activating enzyme (AAE) consensus motif; other site 710421009234 putative active site [active] 710421009235 AMP binding site [chemical binding]; other site 710421009236 putative CoA binding site [chemical binding]; other site 710421009237 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 710421009238 dimer interface [polypeptide binding]; other site 710421009239 substrate binding site [chemical binding]; other site 710421009240 ATP binding site [chemical binding]; other site 710421009241 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710421009242 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710421009243 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 710421009244 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710421009245 RibD C-terminal domain; Region: RibD_C; cl17279 710421009246 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 710421009247 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 710421009248 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710421009249 Sulfatase; Region: Sulfatase; pfam00884 710421009250 lipid-transfer protein; Provisional; Region: PRK07855 710421009251 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421009252 active site 710421009253 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710421009254 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421009255 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421009256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421009257 substrate binding site [chemical binding]; other site 710421009258 oxyanion hole (OAH) forming residues; other site 710421009259 trimer interface [polypeptide binding]; other site 710421009260 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421009261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009262 NAD(P) binding site [chemical binding]; other site 710421009263 active site 710421009264 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710421009265 classical (c) SDRs; Region: SDR_c; cd05233 710421009266 NAD(P) binding site [chemical binding]; other site 710421009267 active site 710421009268 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710421009269 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 710421009270 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421009271 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 710421009272 acyl-activating enzyme (AAE) consensus motif; other site 710421009273 putative AMP binding site [chemical binding]; other site 710421009274 putative active site [active] 710421009275 putative CoA binding site [chemical binding]; other site 710421009276 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710421009277 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421009278 PemK-like protein; Region: PemK; pfam02452 710421009279 Patatin-like phospholipase; Region: Patatin; pfam01734 710421009280 nucleophile elbow; other site 710421009281 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 710421009282 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 710421009283 active site 710421009284 substrate binding site [chemical binding]; other site 710421009285 Mg2+ binding site [ion binding]; other site 710421009286 AAA domain; Region: AAA_14; pfam13173 710421009287 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710421009288 NB-ARC domain; Region: NB-ARC; pfam00931 710421009289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 710421009290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710421009291 binding surface 710421009292 TPR motif; other site 710421009293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 710421009294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710421009295 TPR motif; other site 710421009296 binding surface 710421009297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 710421009298 Tetratricopeptide repeat; Region: TPR_12; pfam13424 710421009299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 710421009300 binding surface 710421009301 TPR motif; other site 710421009302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 710421009303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421009304 AMP-binding enzyme; Region: AMP-binding; pfam00501 710421009305 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421009306 acyl-activating enzyme (AAE) consensus motif; other site 710421009307 acyl-activating enzyme (AAE) consensus motif; other site 710421009308 active site 710421009309 AMP binding site [chemical binding]; other site 710421009310 CoA binding site [chemical binding]; other site 710421009311 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710421009312 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 710421009313 Walker A/P-loop; other site 710421009314 ATP binding site [chemical binding]; other site 710421009315 Q-loop/lid; other site 710421009316 ABC transporter signature motif; other site 710421009317 Walker B; other site 710421009318 D-loop; other site 710421009319 H-loop/switch region; other site 710421009320 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 710421009321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421009322 dimer interface [polypeptide binding]; other site 710421009323 conserved gate region; other site 710421009324 ABC-ATPase subunit interface; other site 710421009325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421009326 dimer interface [polypeptide binding]; other site 710421009327 conserved gate region; other site 710421009328 ABC-ATPase subunit interface; other site 710421009329 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710421009330 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710421009331 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 710421009332 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710421009333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421009334 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421009335 Cutinase; Region: Cutinase; pfam01083 710421009336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421009337 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710421009338 Phosphotransferase enzyme family; Region: APH; pfam01636 710421009339 Ecdysteroid kinase; Region: EcKinase; cl17738 710421009340 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 710421009341 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710421009342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009343 NAD(P) binding site [chemical binding]; other site 710421009344 active site 710421009345 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 710421009346 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710421009347 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421009348 hydrophobic ligand binding site; other site 710421009349 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421009350 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421009351 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 710421009352 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 710421009353 FAD binding pocket [chemical binding]; other site 710421009354 FAD binding motif [chemical binding]; other site 710421009355 phosphate binding motif [ion binding]; other site 710421009356 NAD binding pocket [chemical binding]; other site 710421009357 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710421009358 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 710421009359 active site 2 [active] 710421009360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421009361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009362 NAD(P) binding site [chemical binding]; other site 710421009363 active site 710421009364 TspO/MBR family; Region: TspO_MBR; pfam03073 710421009365 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710421009366 Na binding site [ion binding]; other site 710421009367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421009368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421009369 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421009370 hydrophobic ligand binding site; other site 710421009371 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710421009372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710421009373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421009374 dimer interface [polypeptide binding]; other site 710421009375 conserved gate region; other site 710421009376 putative PBP binding loops; other site 710421009377 ABC-ATPase subunit interface; other site 710421009378 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710421009379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421009380 dimer interface [polypeptide binding]; other site 710421009381 conserved gate region; other site 710421009382 putative PBP binding loops; other site 710421009383 ABC-ATPase subunit interface; other site 710421009384 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 710421009385 short chain dehydrogenase; Provisional; Region: PRK05854 710421009386 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710421009387 putative NAD(P) binding site [chemical binding]; other site 710421009388 active site 710421009389 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 710421009390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009391 NAD(P) binding site [chemical binding]; other site 710421009392 active site 710421009393 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421009394 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421009395 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421009396 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421009397 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421009398 substrate binding site [chemical binding]; other site 710421009399 oxyanion hole (OAH) forming residues; other site 710421009400 trimer interface [polypeptide binding]; other site 710421009401 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421009402 Cytochrome P450; Region: p450; cl12078 710421009403 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 710421009404 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421009405 Cytochrome P450; Region: p450; cl12078 710421009406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421009407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421009408 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421009409 classical (c) SDRs; Region: SDR_c; cd05233 710421009410 NAD(P) binding site [chemical binding]; other site 710421009411 active site 710421009412 enoyl-CoA hydratase; Provisional; Region: PRK08260 710421009413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421009414 substrate binding site [chemical binding]; other site 710421009415 oxyanion hole (OAH) forming residues; other site 710421009416 trimer interface [polypeptide binding]; other site 710421009417 ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133 710421009418 dihydroxyacetone kinase; Provisional; Region: PRK14479 710421009419 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 710421009420 DAK2 domain; Region: Dak2; pfam02734 710421009421 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 710421009422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421009423 Walker A/P-loop; other site 710421009424 ATP binding site [chemical binding]; other site 710421009425 Q-loop/lid; other site 710421009426 ABC transporter signature motif; other site 710421009427 Walker B; other site 710421009428 D-loop; other site 710421009429 H-loop/switch region; other site 710421009430 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 710421009431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421009432 Walker A/P-loop; other site 710421009433 ATP binding site [chemical binding]; other site 710421009434 Q-loop/lid; other site 710421009435 ABC transporter signature motif; other site 710421009436 Walker B; other site 710421009437 D-loop; other site 710421009438 H-loop/switch region; other site 710421009439 TOBE domain; Region: TOBE_2; pfam08402 710421009440 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710421009441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421009442 dimer interface [polypeptide binding]; other site 710421009443 conserved gate region; other site 710421009444 putative PBP binding loops; other site 710421009445 ABC-ATPase subunit interface; other site 710421009446 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710421009447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421009448 dimer interface [polypeptide binding]; other site 710421009449 conserved gate region; other site 710421009450 putative PBP binding loops; other site 710421009451 ABC-ATPase subunit interface; other site 710421009452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710421009453 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710421009454 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421009455 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710421009456 NAD(P) binding site [chemical binding]; other site 710421009457 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 710421009458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421009459 DNA binding residues [nucleotide binding] 710421009460 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 710421009461 short chain dehydrogenase; Provisional; Region: PRK07060 710421009462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009463 NAD(P) binding site [chemical binding]; other site 710421009464 active site 710421009465 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 710421009466 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 710421009467 N- and C-terminal domain interface [polypeptide binding]; other site 710421009468 putative active site [active] 710421009469 MgATP binding site [chemical binding]; other site 710421009470 catalytic site [active] 710421009471 metal binding site [ion binding]; metal-binding site 710421009472 putative xylulose binding site [chemical binding]; other site 710421009473 putative homodimer interface [polypeptide binding]; other site 710421009474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710421009475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421009476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710421009477 dimerization interface [polypeptide binding]; other site 710421009478 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710421009479 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710421009480 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421009481 D-xylulose kinase; Region: XylB; TIGR01312 710421009482 nucleotide binding site [chemical binding]; other site 710421009483 Predicted membrane protein [Function unknown]; Region: COG2259 710421009484 RDD family; Region: RDD; pfam06271 710421009485 GntP family permease; Region: GntP_permease; pfam02447 710421009486 fructuronate transporter; Provisional; Region: PRK10034; cl15264 710421009487 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 710421009488 AAA domain; Region: AAA_33; pfam13671 710421009489 ATP-binding site [chemical binding]; other site 710421009490 Gluconate-6-phosphate binding site [chemical binding]; other site 710421009491 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710421009492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421009493 DNA-binding site [nucleotide binding]; DNA binding site 710421009494 FCD domain; Region: FCD; pfam07729 710421009495 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710421009496 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710421009497 hypothetical protein; Provisional; Region: PRK02237 710421009498 tyramine oxidase; Provisional; Region: tynA; PRK11504 710421009499 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 710421009500 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 710421009501 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 710421009502 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 710421009503 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421009504 substrate binding pocket [chemical binding]; other site 710421009505 catalytic triad [active] 710421009506 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 710421009507 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 710421009508 Ligand binding site; other site 710421009509 Putative Catalytic site; other site 710421009510 DXD motif; other site 710421009511 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 710421009512 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 710421009513 putative active site [active] 710421009514 catalytic triad [active] 710421009515 putative dimer interface [polypeptide binding]; other site 710421009516 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710421009517 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421009518 active site 710421009519 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 710421009520 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 710421009521 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 710421009522 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421009523 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421009524 active site 710421009525 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 710421009526 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710421009527 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 710421009528 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421009529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421009530 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 710421009531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421009532 putative PBP binding loops; other site 710421009533 dimer interface [polypeptide binding]; other site 710421009534 ABC-ATPase subunit interface; other site 710421009535 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 710421009536 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 710421009537 Walker A/P-loop; other site 710421009538 ATP binding site [chemical binding]; other site 710421009539 Q-loop/lid; other site 710421009540 ABC transporter signature motif; other site 710421009541 Walker B; other site 710421009542 D-loop; other site 710421009543 H-loop/switch region; other site 710421009544 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 710421009545 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710421009546 precorrin-3B synthase; Region: CobG; TIGR02435 710421009547 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710421009548 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710421009549 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 710421009550 Precorrin-8X methylmutase; Region: CbiC; pfam02570 710421009551 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 710421009552 active site 710421009553 SAM binding site [chemical binding]; other site 710421009554 homodimer interface [polypeptide binding]; other site 710421009555 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 710421009556 homodimer interface [polypeptide binding]; other site 710421009557 active site 710421009558 SAM binding site [chemical binding]; other site 710421009559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421009560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421009561 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710421009562 Phosphotransferase enzyme family; Region: APH; pfam01636 710421009563 substrate binding site [chemical binding]; other site 710421009564 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 710421009565 active site 710421009566 putative homodimer interface [polypeptide binding]; other site 710421009567 SAM binding site [chemical binding]; other site 710421009568 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 710421009569 Methyltransferase domain; Region: Methyltransf_18; pfam12847 710421009570 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421009571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009572 NAD(P) binding site [chemical binding]; other site 710421009573 active site 710421009574 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421009575 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710421009576 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710421009577 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 710421009578 active site 710421009579 5'-3' exonuclease; Region: 53EXOc; smart00475 710421009580 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710421009581 active site 710421009582 metal binding site 1 [ion binding]; metal-binding site 710421009583 putative 5' ssDNA interaction site; other site 710421009584 metal binding site 3; metal-binding site 710421009585 metal binding site 2 [ion binding]; metal-binding site 710421009586 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710421009587 putative DNA binding site [nucleotide binding]; other site 710421009588 putative metal binding site [ion binding]; other site 710421009589 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 710421009590 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 710421009591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421009592 ATP binding site [chemical binding]; other site 710421009593 putative Mg++ binding site [ion binding]; other site 710421009594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421009595 nucleotide binding region [chemical binding]; other site 710421009596 ATP-binding site [chemical binding]; other site 710421009597 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 710421009598 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 710421009599 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 710421009600 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 710421009601 Predicted transcriptional regulator [Transcription]; Region: COG2378 710421009602 WYL domain; Region: WYL; pfam13280 710421009603 Predicted transcriptional regulator [Transcription]; Region: COG2378 710421009604 WYL domain; Region: WYL; pfam13280 710421009605 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 710421009606 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 710421009607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421009608 Epoxide hydrolase N terminus; Region: EHN; pfam06441 710421009609 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710421009610 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710421009611 active site 710421009612 catalytic tetrad [active] 710421009613 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 710421009614 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710421009615 Bacterial transcriptional regulator; Region: IclR; pfam01614 710421009616 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 710421009617 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 710421009618 ligand binding site [chemical binding]; other site 710421009619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 710421009620 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710421009621 metal binding triad; other site 710421009622 choline dehydrogenase; Validated; Region: PRK02106 710421009623 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710421009624 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710421009625 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710421009626 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421009627 NAD(P) binding site [chemical binding]; other site 710421009628 catalytic residues [active] 710421009629 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421009630 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421009631 [2Fe-2S] cluster binding site [ion binding]; other site 710421009632 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710421009633 hydrophobic ligand binding site; other site 710421009634 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 710421009635 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 710421009636 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710421009637 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710421009638 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 710421009639 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 710421009640 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710421009641 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 710421009642 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 710421009643 active site 710421009644 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 710421009645 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 710421009646 active site 710421009647 Pup-like protein; Region: Pup; cl05289 710421009648 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 710421009649 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 710421009650 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 710421009651 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 710421009652 proteasome ATPase; Region: pup_AAA; TIGR03689 710421009653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421009654 Walker A motif; other site 710421009655 ATP binding site [chemical binding]; other site 710421009656 Walker B motif; other site 710421009657 arginine finger; other site 710421009658 Protein of unknown function (DUF503); Region: DUF503; cl00669 710421009659 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 710421009660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421009661 S-adenosylmethionine binding site [chemical binding]; other site 710421009662 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 710421009663 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 710421009664 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710421009665 MASE1; Region: MASE1; cl17823 710421009666 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710421009667 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710421009668 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 710421009669 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421009670 anti sigma factor interaction site; other site 710421009671 regulatory phosphorylation site [posttranslational modification]; other site 710421009672 GAF domain; Region: GAF; cl17456 710421009673 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421009674 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 710421009675 Bacterial sugar transferase; Region: Bac_transf; pfam02397 710421009676 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 710421009677 Predicted esterase [General function prediction only]; Region: COG0627 710421009678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421009679 dimerization interface [polypeptide binding]; other site 710421009680 putative DNA binding site [nucleotide binding]; other site 710421009681 putative Zn2+ binding site [ion binding]; other site 710421009682 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 710421009683 putative hydrophobic ligand binding site [chemical binding]; other site 710421009684 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 710421009685 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710421009686 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 710421009687 active site 710421009688 diiron metal binding site [ion binding]; other site 710421009689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421009690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421009691 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421009692 mercuric reductase; Validated; Region: PRK06370 710421009693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421009694 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710421009695 Predicted membrane protein [Function unknown]; Region: COG3918 710421009696 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710421009697 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 710421009698 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 710421009699 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 710421009700 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 710421009701 homodimer interface [polypeptide binding]; other site 710421009702 putative metal binding site [ion binding]; other site 710421009703 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 710421009704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421009705 putative substrate translocation pore; other site 710421009706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421009707 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 710421009708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421009709 motif II; other site 710421009710 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 710421009711 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 710421009712 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 710421009713 substrate binding pocket [chemical binding]; other site 710421009714 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 710421009715 B12 binding site [chemical binding]; other site 710421009716 cobalt ligand [ion binding]; other site 710421009717 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 710421009718 PAC2 family; Region: PAC2; pfam09754 710421009719 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710421009720 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 710421009721 active site 710421009722 nucleophile elbow; other site 710421009723 Uncharacterized conserved protein [Function unknown]; Region: COG5361 710421009724 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 710421009725 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 710421009726 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710421009727 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 710421009728 active site 710421009729 HIGH motif; other site 710421009730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710421009731 active site 710421009732 KMSKS motif; other site 710421009733 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 710421009734 putative tRNA binding surface [nucleotide binding]; other site 710421009735 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 710421009736 active site 710421009737 conserved hypothetical protein; Region: TIGR03843 710421009738 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 710421009739 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421009740 catalytic core [active] 710421009741 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 710421009742 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 710421009743 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 710421009744 quinone interaction residues [chemical binding]; other site 710421009745 active site 710421009746 catalytic residues [active] 710421009747 FMN binding site [chemical binding]; other site 710421009748 substrate binding site [chemical binding]; other site 710421009749 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710421009750 substrate binding site [chemical binding]; other site 710421009751 hypothetical protein; Provisional; Region: PRK07906 710421009752 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 710421009753 putative metal binding site [ion binding]; other site 710421009754 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710421009755 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 710421009756 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 710421009757 [4Fe-4S] binding site [ion binding]; other site 710421009758 molybdopterin cofactor binding site; other site 710421009759 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 710421009760 molybdopterin cofactor binding site; other site 710421009761 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 710421009762 Flavodoxin; Region: Flavodoxin_1; pfam00258 710421009763 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 710421009764 FAD binding pocket [chemical binding]; other site 710421009765 conserved FAD binding motif [chemical binding]; other site 710421009766 phosphate binding motif [ion binding]; other site 710421009767 beta-alpha-beta structure motif; other site 710421009768 NAD binding pocket [chemical binding]; other site 710421009769 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 710421009770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421009771 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 710421009772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421009773 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 710421009774 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710421009775 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710421009776 iron-sulfur cluster [ion binding]; other site 710421009777 [2Fe-2S] cluster binding site [ion binding]; other site 710421009778 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421009779 Cytochrome P450; Region: p450; cl12078 710421009780 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 710421009781 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 710421009782 catalytic triad [active] 710421009783 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 710421009784 putative hydrophobic ligand binding site [chemical binding]; other site 710421009785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009786 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 710421009787 NAD(P) binding site [chemical binding]; other site 710421009788 active site 710421009789 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421009790 active site 710421009791 DivIVA domain; Region: DivI1A_domain; TIGR03544 710421009792 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 710421009793 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 710421009794 Predicted integral membrane protein [Function unknown]; Region: COG0762 710421009795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 710421009796 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 710421009797 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710421009798 catalytic residue [active] 710421009799 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 710421009800 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 710421009801 cell division protein FtsZ; Validated; Region: PRK09330 710421009802 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 710421009803 nucleotide binding site [chemical binding]; other site 710421009804 SulA interaction site; other site 710421009805 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 710421009806 Cell division protein FtsQ; Region: FtsQ; pfam03799 710421009807 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 710421009808 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710421009809 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710421009810 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710421009811 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 710421009812 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 710421009813 active site 710421009814 homodimer interface [polypeptide binding]; other site 710421009815 cell division protein FtsW; Region: ftsW; TIGR02614 710421009816 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 710421009817 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710421009818 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710421009819 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 710421009820 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 710421009821 Mg++ binding site [ion binding]; other site 710421009822 putative catalytic motif [active] 710421009823 putative substrate binding site [chemical binding]; other site 710421009824 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 710421009825 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 710421009826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710421009827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710421009828 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 710421009829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 710421009830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710421009831 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 710421009832 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 710421009833 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710421009834 MraW methylase family; Region: Methyltransf_5; pfam01795 710421009835 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 710421009836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 710421009837 MraZ protein; Region: MraZ; pfam02381 710421009838 MraZ protein; Region: MraZ; pfam02381 710421009839 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 710421009840 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 710421009841 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710421009842 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 710421009843 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 710421009844 substrate binding pocket [chemical binding]; other site 710421009845 chain length determination region; other site 710421009846 substrate-Mg2+ binding site; other site 710421009847 catalytic residues [active] 710421009848 aspartate-rich region 1; other site 710421009849 active site lid residues [active] 710421009850 aspartate-rich region 2; other site 710421009851 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 710421009852 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421009853 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421009854 active site 710421009855 ATP binding site [chemical binding]; other site 710421009856 substrate binding site [chemical binding]; other site 710421009857 activation loop (A-loop); other site 710421009858 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 710421009859 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 710421009860 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421009861 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710421009862 putative acyl-acceptor binding pocket; other site 710421009863 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710421009864 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710421009865 P loop; other site 710421009866 Nucleotide binding site [chemical binding]; other site 710421009867 DTAP/Switch II; other site 710421009868 Switch I; other site 710421009869 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710421009870 putative hydrophobic ligand binding site [chemical binding]; other site 710421009871 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 710421009872 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 710421009873 acyl-activating enzyme (AAE) consensus motif; other site 710421009874 putative AMP binding site [chemical binding]; other site 710421009875 putative active site [active] 710421009876 putative CoA binding site [chemical binding]; other site 710421009877 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421009878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421009879 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 710421009880 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 710421009881 NlpC/P60 family; Region: NLPC_P60; pfam00877 710421009882 hypothetical protein; Validated; Region: PRK07883 710421009883 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710421009884 active site 710421009885 catalytic site [active] 710421009886 substrate binding site [chemical binding]; other site 710421009887 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710421009888 GIY-YIG motif/motif A; other site 710421009889 active site 710421009890 catalytic site [active] 710421009891 putative DNA binding site [nucleotide binding]; other site 710421009892 metal binding site [ion binding]; metal-binding site 710421009893 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 710421009894 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710421009895 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710421009896 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 710421009897 Subunit I/III interface [polypeptide binding]; other site 710421009898 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 710421009899 Cytochrome c; Region: Cytochrom_C; pfam00034 710421009900 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 710421009901 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 710421009902 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 710421009903 iron-sulfur cluster [ion binding]; other site 710421009904 [2Fe-2S] cluster binding site [ion binding]; other site 710421009905 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 710421009906 heme bH binding site [chemical binding]; other site 710421009907 Qi binding site; other site 710421009908 intrachain domain interface; other site 710421009909 heme bL binding site [chemical binding]; other site 710421009910 interchain domain interface [polypeptide binding]; other site 710421009911 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 710421009912 Qo binding site; other site 710421009913 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 710421009914 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710421009915 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 710421009916 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 710421009917 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 710421009918 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 710421009919 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710421009920 active site 710421009921 dimer interface [polypeptide binding]; other site 710421009922 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710421009923 Ligand Binding Site [chemical binding]; other site 710421009924 Molecular Tunnel; other site 710421009925 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 710421009926 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710421009927 substrate binding site [chemical binding]; other site 710421009928 ATP binding site [chemical binding]; other site 710421009929 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 710421009930 Glycerate kinase family; Region: Gly_kinase; cl00841 710421009931 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 710421009932 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 710421009933 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 710421009934 active site pocket [active] 710421009935 putative dimer interface [polypeptide binding]; other site 710421009936 putative cataytic base [active] 710421009937 cobalamin synthase; Reviewed; Region: cobS; PRK00235 710421009938 Cutinase; Region: Cutinase; pfam01083 710421009939 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 710421009940 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 710421009941 homodimer interface [polypeptide binding]; other site 710421009942 substrate-cofactor binding pocket; other site 710421009943 catalytic residue [active] 710421009944 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 710421009945 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710421009946 multifunctional aminopeptidase A; Provisional; Region: PRK00913 710421009947 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 710421009948 interface (dimer of trimers) [polypeptide binding]; other site 710421009949 Substrate-binding/catalytic site; other site 710421009950 Zn-binding sites [ion binding]; other site 710421009951 short chain dehydrogenase; Validated; Region: PRK05855 710421009952 classical (c) SDRs; Region: SDR_c; cd05233 710421009953 NAD(P) binding site [chemical binding]; other site 710421009954 active site 710421009955 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710421009956 E3 interaction surface; other site 710421009957 lipoyl attachment site [posttranslational modification]; other site 710421009958 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710421009959 E3 interaction surface; other site 710421009960 lipoyl attachment site [posttranslational modification]; other site 710421009961 e3 binding domain; Region: E3_binding; pfam02817 710421009962 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 710421009963 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710421009964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009965 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 710421009966 NAD(P) binding site [chemical binding]; other site 710421009967 active site 710421009968 lipoate-protein ligase B; Provisional; Region: PRK14345 710421009969 lipoyl synthase; Provisional; Region: PRK05481 710421009970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421009971 FeS/SAM binding site; other site 710421009972 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 710421009973 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710421009974 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 710421009975 active site 710421009976 RDD family; Region: RDD; pfam06271 710421009977 glutamine synthetase, type I; Region: GlnA; TIGR00653 710421009978 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710421009979 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710421009980 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421009981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421009982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421009983 NAD(P) binding site [chemical binding]; other site 710421009984 active site 710421009985 DoxX; Region: DoxX; pfam07681 710421009986 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421009987 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421009988 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421009989 CoenzymeA binding site [chemical binding]; other site 710421009990 subunit interaction site [polypeptide binding]; other site 710421009991 PHB binding site; other site 710421009992 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 710421009993 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710421009994 metal binding triad; other site 710421009995 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710421009996 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 710421009997 metal binding triad; other site 710421009998 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 710421009999 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 710421010000 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710421010001 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710421010002 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710421010003 TAP-like protein; Region: Abhydrolase_4; pfam08386 710421010004 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 710421010005 TAP-like protein; Region: Abhydrolase_4; pfam08386 710421010006 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421010007 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421010008 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710421010009 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 710421010010 oligomerization interface [polypeptide binding]; other site 710421010011 active site 710421010012 metal binding site [ion binding]; metal-binding site 710421010013 enoyl-CoA hydratase; Provisional; Region: PRK08140 710421010014 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421010015 substrate binding site [chemical binding]; other site 710421010016 oxyanion hole (OAH) forming residues; other site 710421010017 trimer interface [polypeptide binding]; other site 710421010018 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 710421010019 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710421010020 acyl-activating enzyme (AAE) consensus motif; other site 710421010021 active site 710421010022 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 710421010023 putative active site; other site 710421010024 putative metal binding residues [ion binding]; other site 710421010025 signature motif; other site 710421010026 putative triphosphate binding site [ion binding]; other site 710421010027 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 710421010028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421010029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421010030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421010031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421010032 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 710421010033 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421010034 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421010035 active site 710421010036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421010037 S-adenosylmethionine binding site [chemical binding]; other site 710421010038 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 710421010039 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421010040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421010041 sequence-specific DNA binding site [nucleotide binding]; other site 710421010042 salt bridge; other site 710421010043 Cupin domain; Region: Cupin_2; pfam07883 710421010044 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 710421010045 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 710421010046 RNA/DNA hybrid binding site [nucleotide binding]; other site 710421010047 active site 710421010048 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421010049 catalytic core [active] 710421010050 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 710421010051 Putative zinc ribbon domain; Region: DUF164; pfam02591 710421010052 Uncharacterized conserved protein [Function unknown]; Region: COG0327 710421010053 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 710421010054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 710421010055 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 710421010056 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 710421010057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421010058 motif II; other site 710421010059 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710421010060 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 710421010061 active site 710421010062 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 710421010063 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 710421010064 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 710421010065 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421010066 active site 710421010067 Phosphoesterase family; Region: Phosphoesterase; pfam04185 710421010068 Dodecin; Region: Dodecin; pfam07311 710421010069 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 710421010070 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 710421010071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421010072 active site 710421010073 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010074 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421010075 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710421010076 acyl-activating enzyme (AAE) consensus motif; other site 710421010077 active site 710421010078 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421010079 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710421010080 putative acyl-acceptor binding pocket; other site 710421010081 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 710421010082 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 710421010083 putative active site [active] 710421010084 putative metal binding site [ion binding]; other site 710421010085 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421010086 active site 710421010087 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710421010088 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710421010089 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 710421010090 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 710421010091 dimer interface [polypeptide binding]; other site 710421010092 catalytic triad [active] 710421010093 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 710421010094 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 710421010095 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 710421010096 dimer interface [polypeptide binding]; other site 710421010097 TPP-binding site [chemical binding]; other site 710421010098 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 710421010099 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421010100 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710421010101 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710421010102 acyl carrier protein; Provisional; Region: acpP; PRK00982 710421010103 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710421010104 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710421010105 dimer interface [polypeptide binding]; other site 710421010106 active site 710421010107 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710421010108 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710421010109 dimer interface [polypeptide binding]; other site 710421010110 active site 710421010111 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710421010112 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710421010113 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421010114 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 710421010115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421010116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421010117 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710421010118 FAD binding domain; Region: FAD_binding_4; pfam01565 710421010119 diacylglycerol kinase; Reviewed; Region: PRK11914 710421010120 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 710421010121 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 710421010122 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421010123 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421010124 mechanosensitive channel MscS; Provisional; Region: PRK10334 710421010125 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710421010126 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 710421010127 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710421010128 NAD binding site [chemical binding]; other site 710421010129 catalytic Zn binding site [ion binding]; other site 710421010130 substrate binding site [chemical binding]; other site 710421010131 structural Zn binding site [ion binding]; other site 710421010132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421010133 Short C-terminal domain; Region: SHOCT; pfam09851 710421010134 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 710421010135 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421010136 nucleotide binding site [chemical binding]; other site 710421010137 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421010138 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710421010139 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 710421010140 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710421010141 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710421010142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421010143 dimer interface [polypeptide binding]; other site 710421010144 conserved gate region; other site 710421010145 putative PBP binding loops; other site 710421010146 ABC-ATPase subunit interface; other site 710421010147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710421010148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421010149 putative PBP binding loops; other site 710421010150 dimer interface [polypeptide binding]; other site 710421010151 ABC-ATPase subunit interface; other site 710421010152 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 710421010153 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710421010154 Walker A/P-loop; other site 710421010155 ATP binding site [chemical binding]; other site 710421010156 Q-loop/lid; other site 710421010157 ABC transporter signature motif; other site 710421010158 Walker B; other site 710421010159 D-loop; other site 710421010160 H-loop/switch region; other site 710421010161 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710421010162 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710421010163 Walker A/P-loop; other site 710421010164 ATP binding site [chemical binding]; other site 710421010165 Q-loop/lid; other site 710421010166 ABC transporter signature motif; other site 710421010167 Walker B; other site 710421010168 D-loop; other site 710421010169 H-loop/switch region; other site 710421010170 classical (c) SDRs; Region: SDR_c; cd05233 710421010171 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 710421010172 NAD(P) binding site [chemical binding]; other site 710421010173 active site 710421010174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421010175 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421010176 Cytochrome P450; Region: p450; cl12078 710421010177 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421010178 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710421010179 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421010180 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421010181 [2Fe-2S] cluster binding site [ion binding]; other site 710421010182 Aluminium induced protein; Region: DUF3700; pfam12481 710421010183 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 710421010184 AzlC protein; Region: AzlC; cl00570 710421010185 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421010186 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 710421010187 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 710421010188 active site 710421010189 Zn binding site [ion binding]; other site 710421010190 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710421010191 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710421010192 active site 710421010193 catalytic tetrad [active] 710421010194 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 710421010195 putative active site [active] 710421010196 putative metal binding site [ion binding]; other site 710421010197 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710421010198 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 710421010199 POT family; Region: PTR2; cl17359 710421010200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421010201 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710421010202 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 710421010203 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710421010204 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 710421010205 NAD(P) binding site [chemical binding]; other site 710421010206 catalytic residues [active] 710421010207 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 710421010208 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 710421010209 putative NAD(P) binding site [chemical binding]; other site 710421010210 active site 710421010211 putative substrate binding site [chemical binding]; other site 710421010212 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710421010213 Sulfatase; Region: Sulfatase; pfam00884 710421010214 Sulfatase; Region: Sulfatase; cl17466 710421010215 Secretory lipase; Region: LIP; pfam03583 710421010216 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710421010217 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 710421010218 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 710421010219 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 710421010220 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 710421010221 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710421010222 Walker A/P-loop; other site 710421010223 ATP binding site [chemical binding]; other site 710421010224 Q-loop/lid; other site 710421010225 ABC transporter signature motif; other site 710421010226 Walker B; other site 710421010227 D-loop; other site 710421010228 H-loop/switch region; other site 710421010229 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710421010230 Walker A/P-loop; other site 710421010231 ATP binding site [chemical binding]; other site 710421010232 Q-loop/lid; other site 710421010233 ABC transporter signature motif; other site 710421010234 Walker B; other site 710421010235 D-loop; other site 710421010236 H-loop/switch region; other site 710421010237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710421010238 MarR family; Region: MarR; pfam01047 710421010239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421010240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421010241 putative substrate translocation pore; other site 710421010242 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 710421010243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421010244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421010245 active site 710421010246 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 710421010247 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710421010248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421010249 putative substrate translocation pore; other site 710421010250 DNA primase; Validated; Region: dnaG; PRK05667 710421010251 CHC2 zinc finger; Region: zf-CHC2; cl17510 710421010252 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 710421010253 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 710421010254 active site 710421010255 metal binding site [ion binding]; metal-binding site 710421010256 interdomain interaction site; other site 710421010257 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 710421010258 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 710421010259 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 710421010260 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710421010261 Zn2+ binding site [ion binding]; other site 710421010262 Mg2+ binding site [ion binding]; other site 710421010263 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 710421010264 Repair protein; Region: Repair_PSII; pfam04536 710421010265 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710421010266 glycyl-tRNA synthetase; Provisional; Region: PRK04173 710421010267 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710421010268 motif 1; other site 710421010269 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 710421010270 active site 710421010271 motif 2; other site 710421010272 motif 3; other site 710421010273 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 710421010274 anticodon binding site; other site 710421010275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421010276 dimerization interface [polypeptide binding]; other site 710421010277 putative DNA binding site [nucleotide binding]; other site 710421010278 putative Zn2+ binding site [ion binding]; other site 710421010279 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 710421010280 metal binding site 2 [ion binding]; metal-binding site 710421010281 putative DNA binding helix; other site 710421010282 metal binding site 1 [ion binding]; metal-binding site 710421010283 dimer interface [polypeptide binding]; other site 710421010284 structural Zn2+ binding site [ion binding]; other site 710421010285 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 710421010286 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 710421010287 catalytic residue [active] 710421010288 putative FPP diphosphate binding site; other site 710421010289 putative FPP binding hydrophobic cleft; other site 710421010290 dimer interface [polypeptide binding]; other site 710421010291 putative IPP diphosphate binding site; other site 710421010292 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 710421010293 Recombination protein O N terminal; Region: RecO_N; pfam11967 710421010294 Recombination protein O C terminal; Region: RecO_C; pfam02565 710421010295 amidase; Provisional; Region: PRK06061 710421010296 Amidase; Region: Amidase; pfam01425 710421010297 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 710421010298 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710421010299 GTPase Era; Reviewed; Region: era; PRK00089 710421010300 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 710421010301 G1 box; other site 710421010302 GTP/Mg2+ binding site [chemical binding]; other site 710421010303 Switch I region; other site 710421010304 G2 box; other site 710421010305 Switch II region; other site 710421010306 G3 box; other site 710421010307 G4 box; other site 710421010308 G5 box; other site 710421010309 KH domain; Region: KH_2; pfam07650 710421010310 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710421010311 Domain of unknown function DUF21; Region: DUF21; pfam01595 710421010312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710421010313 Transporter associated domain; Region: CorC_HlyC; smart01091 710421010314 metal-binding heat shock protein; Provisional; Region: PRK00016 710421010315 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 710421010316 PhoH-like protein; Region: PhoH; pfam02562 710421010317 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 710421010318 chaperone protein DnaJ; Provisional; Region: PRK14278 710421010319 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710421010320 HSP70 interaction site [polypeptide binding]; other site 710421010321 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710421010322 Zn binding sites [ion binding]; other site 710421010323 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710421010324 dimer interface [polypeptide binding]; other site 710421010325 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 710421010326 HTH domain; Region: HTH_11; cl17392 710421010327 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 710421010328 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421010329 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710421010330 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 710421010331 coproporphyrinogen III oxidase; Validated; Region: PRK05628 710421010332 HemN C-terminal domain; Region: HemN_C; pfam06969 710421010333 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 710421010334 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710421010335 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 710421010336 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 710421010337 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710421010338 Active Sites [active] 710421010339 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 710421010340 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 710421010341 putative active site [active] 710421010342 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 710421010343 putative active site [active] 710421010344 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421010345 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421010346 active site residue [active] 710421010347 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 710421010348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421010349 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 710421010350 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 710421010351 Walker A/P-loop; other site 710421010352 ATP binding site [chemical binding]; other site 710421010353 Q-loop/lid; other site 710421010354 ABC transporter signature motif; other site 710421010355 Walker B; other site 710421010356 D-loop; other site 710421010357 H-loop/switch region; other site 710421010358 TOBE-like domain; Region: TOBE_3; pfam12857 710421010359 sulfate transport protein; Provisional; Region: cysT; CHL00187 710421010360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421010361 dimer interface [polypeptide binding]; other site 710421010362 conserved gate region; other site 710421010363 putative PBP binding loops; other site 710421010364 ABC-ATPase subunit interface; other site 710421010365 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 710421010366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421010367 dimer interface [polypeptide binding]; other site 710421010368 conserved gate region; other site 710421010369 putative PBP binding loops; other site 710421010370 ABC-ATPase subunit interface; other site 710421010371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710421010372 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 710421010373 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710421010374 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710421010375 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710421010376 PknH-like extracellular domain; Region: PknH_C; pfam14032 710421010377 PknH-like extracellular domain; Region: PknH_C; pfam14032 710421010378 GTP-binding protein LepA; Provisional; Region: PRK05433 710421010379 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 710421010380 G1 box; other site 710421010381 putative GEF interaction site [polypeptide binding]; other site 710421010382 GTP/Mg2+ binding site [chemical binding]; other site 710421010383 Switch I region; other site 710421010384 G2 box; other site 710421010385 G3 box; other site 710421010386 Switch II region; other site 710421010387 G4 box; other site 710421010388 G5 box; other site 710421010389 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710421010390 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 710421010391 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 710421010392 PemK-like protein; Region: PemK; pfam02452 710421010393 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 710421010394 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421010395 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 710421010396 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421010397 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 710421010398 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 710421010399 NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005 710421010400 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 710421010401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 710421010402 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 710421010403 FOG: CBS domain [General function prediction only]; Region: COG0517 710421010404 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710421010405 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710421010406 active site 710421010407 catalytic tetrad [active] 710421010408 ribonuclease Z; Reviewed; Region: PRK00055 710421010409 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710421010410 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 710421010411 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710421010412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 710421010413 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 710421010414 Uncharacterized conserved protein [Function unknown]; Region: COG2308 710421010415 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 710421010416 hypothetical protein; Reviewed; Region: PRK07914 710421010417 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 710421010418 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 710421010419 Competence protein; Region: Competence; pfam03772 710421010420 Helix-hairpin-helix motif; Region: HHH; pfam00633 710421010421 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 710421010422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421010423 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421010424 active site 710421010425 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421010426 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710421010427 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421010428 short chain dehydrogenase; Provisional; Region: PRK08303 710421010429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421010430 NAD(P) binding site [chemical binding]; other site 710421010431 active site 710421010432 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421010433 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 710421010434 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 710421010435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421010436 H+ Antiporter protein; Region: 2A0121; TIGR00900 710421010437 putative substrate translocation pore; other site 710421010438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710421010439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421010440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710421010441 dimerization interface [polypeptide binding]; other site 710421010442 EDD domain protein, DegV family; Region: DegV; TIGR00762 710421010443 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 710421010444 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710421010445 active site 710421010446 catalytic triad [active] 710421010447 oxyanion hole [active] 710421010448 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421010449 catalytic core [active] 710421010450 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 710421010451 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 710421010452 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 710421010453 active site 710421010454 (T/H)XGH motif; other site 710421010455 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 710421010456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421010457 DNA-binding site [nucleotide binding]; DNA binding site 710421010458 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710421010459 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710421010460 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 710421010461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421010462 nucleotide binding site [chemical binding]; other site 710421010463 Predicted dehydrogenase [General function prediction only]; Region: COG0579 710421010464 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710421010465 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 710421010466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 710421010467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421010468 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 710421010469 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710421010470 metal ion-dependent adhesion site (MIDAS); other site 710421010471 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710421010472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421010473 Walker A motif; other site 710421010474 ATP binding site [chemical binding]; other site 710421010475 Walker B motif; other site 710421010476 arginine finger; other site 710421010477 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 710421010478 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 710421010479 putative catalytic cysteine [active] 710421010480 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710421010481 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 710421010482 substrate binding site [chemical binding]; other site 710421010483 ATP binding site [chemical binding]; other site 710421010484 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421010485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421010486 substrate binding site [chemical binding]; other site 710421010487 oxyanion hole (OAH) forming residues; other site 710421010488 trimer interface [polypeptide binding]; other site 710421010489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421010490 putative DNA binding site [nucleotide binding]; other site 710421010491 dimerization interface [polypeptide binding]; other site 710421010492 putative Zn2+ binding site [ion binding]; other site 710421010493 Cation efflux family; Region: Cation_efflux; cl00316 710421010494 NAD synthetase; Reviewed; Region: nadE; PRK02628 710421010495 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 710421010496 multimer interface [polypeptide binding]; other site 710421010497 active site 710421010498 catalytic triad [active] 710421010499 protein interface 1 [polypeptide binding]; other site 710421010500 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 710421010501 homodimer interface [polypeptide binding]; other site 710421010502 NAD binding pocket [chemical binding]; other site 710421010503 ATP binding pocket [chemical binding]; other site 710421010504 Mg binding site [ion binding]; other site 710421010505 active-site loop [active] 710421010506 Isochorismatase family; Region: Isochorismatase; pfam00857 710421010507 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 710421010508 catalytic triad [active] 710421010509 conserved cis-peptide bond; other site 710421010510 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 710421010511 NAD-dependent deacetylase; Provisional; Region: PRK05333 710421010512 NAD+ binding site [chemical binding]; other site 710421010513 substrate binding site [chemical binding]; other site 710421010514 Zn binding site [ion binding]; other site 710421010515 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421010516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421010517 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421010518 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421010519 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421010520 active site 710421010521 gamma-glutamyl kinase; Provisional; Region: PRK05429 710421010522 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 710421010523 nucleotide binding site [chemical binding]; other site 710421010524 homotetrameric interface [polypeptide binding]; other site 710421010525 putative phosphate binding site [ion binding]; other site 710421010526 putative allosteric binding site; other site 710421010527 PUA domain; Region: PUA; pfam01472 710421010528 GTPase CgtA; Reviewed; Region: obgE; PRK12296 710421010529 GTP1/OBG; Region: GTP1_OBG; pfam01018 710421010530 Obg GTPase; Region: Obg; cd01898 710421010531 G1 box; other site 710421010532 GTP/Mg2+ binding site [chemical binding]; other site 710421010533 Switch I region; other site 710421010534 G2 box; other site 710421010535 G3 box; other site 710421010536 Switch II region; other site 710421010537 G4 box; other site 710421010538 G5 box; other site 710421010539 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 710421010540 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 710421010541 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 710421010542 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 710421010543 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710421010544 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 710421010545 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 710421010546 homodimer interface [polypeptide binding]; other site 710421010547 oligonucleotide binding site [chemical binding]; other site 710421010548 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 710421010549 active site 710421010550 multimer interface [polypeptide binding]; other site 710421010551 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 710421010552 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 710421010553 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 710421010554 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 710421010555 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710421010556 active site 710421010557 HIGH motif; other site 710421010558 nucleotide binding site [chemical binding]; other site 710421010559 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710421010560 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 710421010561 active site 710421010562 KMSKS motif; other site 710421010563 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 710421010564 tRNA binding surface [nucleotide binding]; other site 710421010565 anticodon binding site; other site 710421010566 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 710421010567 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 710421010568 Uncharacterized conserved protein [Function unknown]; Region: COG3268 710421010569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421010570 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 710421010571 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421010572 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421010573 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710421010574 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710421010575 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 710421010576 GTP binding site; other site 710421010577 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 710421010578 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 710421010579 TPP-binding site [chemical binding]; other site 710421010580 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 710421010581 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 710421010582 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 710421010583 dimer interface [polypeptide binding]; other site 710421010584 PYR/PP interface [polypeptide binding]; other site 710421010585 TPP binding site [chemical binding]; other site 710421010586 substrate binding site [chemical binding]; other site 710421010587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710421010588 DNA binding site [nucleotide binding] 710421010589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 710421010590 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 710421010591 putative ligand binding site [chemical binding]; other site 710421010592 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 710421010593 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710421010594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710421010595 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710421010596 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 710421010597 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710421010598 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710421010599 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710421010600 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 710421010601 Walker A/P-loop; other site 710421010602 ATP binding site [chemical binding]; other site 710421010603 Q-loop/lid; other site 710421010604 ABC transporter signature motif; other site 710421010605 Walker B; other site 710421010606 D-loop; other site 710421010607 H-loop/switch region; other site 710421010608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710421010609 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 710421010610 TM-ABC transporter signature motif; other site 710421010611 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 710421010612 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 710421010613 putative ligand binding site [chemical binding]; other site 710421010614 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710421010615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710421010616 DNA binding site [nucleotide binding] 710421010617 domain linker motif; other site 710421010618 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 710421010619 ligand binding site [chemical binding]; other site 710421010620 dimerization interface [polypeptide binding]; other site 710421010621 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710421010622 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710421010623 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 710421010624 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710421010625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421010626 DNA-binding site [nucleotide binding]; DNA binding site 710421010627 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710421010628 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710421010629 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 710421010630 substrate binding site [chemical binding]; other site 710421010631 ATP binding site [chemical binding]; other site 710421010632 KduI/IolB family; Region: KduI; pfam04962 710421010633 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 710421010634 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710421010635 PYR/PP interface [polypeptide binding]; other site 710421010636 dimer interface [polypeptide binding]; other site 710421010637 TPP binding site [chemical binding]; other site 710421010638 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710421010639 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 710421010640 TPP-binding site; other site 710421010641 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 710421010642 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710421010643 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 710421010644 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 710421010645 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 710421010646 tetrameric interface [polypeptide binding]; other site 710421010647 NAD binding site [chemical binding]; other site 710421010648 catalytic residues [active] 710421010649 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710421010650 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 710421010651 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 710421010652 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 710421010653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421010654 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 710421010655 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 710421010656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421010657 Walker A motif; other site 710421010658 ATP binding site [chemical binding]; other site 710421010659 Walker B motif; other site 710421010660 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 710421010661 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421010662 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 710421010663 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710421010664 oligomer interface [polypeptide binding]; other site 710421010665 active site residues [active] 710421010666 Clp protease; Region: CLP_protease; pfam00574 710421010667 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 710421010668 oligomer interface [polypeptide binding]; other site 710421010669 active site residues [active] 710421010670 trigger factor; Provisional; Region: tig; PRK01490 710421010671 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710421010672 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710421010673 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421010674 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 710421010675 cyclase homology domain; Region: CHD; cd07302 710421010676 nucleotidyl binding site; other site 710421010677 metal binding site [ion binding]; metal-binding site 710421010678 dimer interface [polypeptide binding]; other site 710421010679 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710421010680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710421010681 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 710421010682 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710421010683 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 710421010684 putative DNA binding site [nucleotide binding]; other site 710421010685 catalytic residue [active] 710421010686 putative H2TH interface [polypeptide binding]; other site 710421010687 putative catalytic residues [active] 710421010688 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710421010689 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710421010690 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 710421010691 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710421010692 nucleoside/Zn binding site; other site 710421010693 dimer interface [polypeptide binding]; other site 710421010694 catalytic motif [active] 710421010695 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 710421010696 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 710421010697 catalytic residues [active] 710421010698 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 710421010699 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 710421010700 Zn binding site [ion binding]; other site 710421010701 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710421010702 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421010703 Integrase core domain; Region: rve; pfam00665 710421010704 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421010705 active site 710421010706 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 710421010707 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421010708 active site 710421010709 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 710421010710 putative heme binding pocket [chemical binding]; other site 710421010711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421010712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421010713 DNA binding residues [nucleotide binding] 710421010714 dimerization interface [polypeptide binding]; other site 710421010715 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 710421010716 apolar tunnel; other site 710421010717 heme binding site [chemical binding]; other site 710421010718 dimerization interface [polypeptide binding]; other site 710421010719 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710421010720 active site 710421010721 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 710421010722 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 710421010723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421010724 Walker A/P-loop; other site 710421010725 ATP binding site [chemical binding]; other site 710421010726 Q-loop/lid; other site 710421010727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710421010728 ABC transporter; Region: ABC_tran_2; pfam12848 710421010729 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710421010730 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710421010731 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710421010732 dimer interface [polypeptide binding]; other site 710421010733 ssDNA binding site [nucleotide binding]; other site 710421010734 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710421010735 Copper resistance protein D; Region: CopD; pfam05425 710421010736 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 710421010737 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 710421010738 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 710421010739 putative acyl-acceptor binding pocket; other site 710421010740 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 710421010741 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710421010742 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421010743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710421010744 putative acyl-acceptor binding pocket; other site 710421010745 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421010746 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421010747 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 710421010748 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 710421010749 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 710421010750 Transport protein; Region: actII; TIGR00833 710421010751 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 710421010752 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421010753 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710421010754 MbtH-like protein; Region: MbtH; pfam03621 710421010755 potential frameshift: common BLAST hit: gi|379762187|ref|YP_005348584.1| linear gramicidin synthetase subunit D 710421010756 Condensation domain; Region: Condensation; pfam00668 710421010757 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010758 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710421010759 acyl-activating enzyme (AAE) consensus motif; other site 710421010760 AMP binding site [chemical binding]; other site 710421010761 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010762 Condensation domain; Region: Condensation; pfam00668 710421010763 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710421010764 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710421010765 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010766 acyl-activating enzyme (AAE) consensus motif; other site 710421010767 AMP binding site [chemical binding]; other site 710421010768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010769 Condensation domain; Region: Condensation; pfam00668 710421010770 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710421010771 Condensation domain; Region: Condensation; pfam00668 710421010772 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710421010773 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710421010774 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010775 AMP-binding enzyme; Region: AMP-binding; pfam00501 710421010776 acyl-activating enzyme (AAE) consensus motif; other site 710421010777 AMP binding site [chemical binding]; other site 710421010778 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010779 peptide synthase; Provisional; Region: PRK12316 710421010780 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710421010781 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010782 acyl-activating enzyme (AAE) consensus motif; other site 710421010783 AMP binding site [chemical binding]; other site 710421010784 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010785 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710421010786 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710421010787 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010788 acyl-activating enzyme (AAE) consensus motif; other site 710421010789 AMP binding site [chemical binding]; other site 710421010790 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010791 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710421010792 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010793 acyl-activating enzyme (AAE) consensus motif; other site 710421010794 AMP binding site [chemical binding]; other site 710421010795 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010796 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 710421010797 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710421010798 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010799 acyl-activating enzyme (AAE) consensus motif; other site 710421010800 AMP binding site [chemical binding]; other site 710421010801 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010802 Condensation domain; Region: Condensation; pfam00668 710421010803 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 710421010804 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 710421010805 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421010806 acyl-activating enzyme (AAE) consensus motif; other site 710421010807 AMP binding site [chemical binding]; other site 710421010808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421010809 S-adenosylmethionine binding site [chemical binding]; other site 710421010810 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421010811 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421010812 Thioesterase domain; Region: Thioesterase; pfam00975 710421010813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421010814 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421010815 anti sigma factor interaction site; other site 710421010816 regulatory phosphorylation site [posttranslational modification]; other site 710421010817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 710421010818 GAF domain; Region: GAF; cl17456 710421010819 GAF domain; Region: GAF_3; pfam13492 710421010820 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710421010821 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710421010822 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 710421010823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421010824 ATP binding site [chemical binding]; other site 710421010825 Mg2+ binding site [ion binding]; other site 710421010826 G-X-G motif; other site 710421010827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421010828 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710421010829 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 710421010830 Predicted ATPase [General function prediction only]; Region: COG3903 710421010831 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 710421010832 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710421010833 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 710421010834 enoyl-CoA hydratase; Provisional; Region: PRK05870 710421010835 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421010836 substrate binding site [chemical binding]; other site 710421010837 oxyanion hole (OAH) forming residues; other site 710421010838 trimer interface [polypeptide binding]; other site 710421010839 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 710421010840 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710421010841 E3 interaction surface; other site 710421010842 lipoyl attachment site [posttranslational modification]; other site 710421010843 e3 binding domain; Region: E3_binding; pfam02817 710421010844 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710421010845 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710421010846 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710421010847 alpha subunit interface [polypeptide binding]; other site 710421010848 TPP binding site [chemical binding]; other site 710421010849 heterodimer interface [polypeptide binding]; other site 710421010850 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710421010851 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710421010852 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710421010853 tetramer interface [polypeptide binding]; other site 710421010854 TPP-binding site [chemical binding]; other site 710421010855 heterodimer interface [polypeptide binding]; other site 710421010856 phosphorylation loop region [posttranslational modification] 710421010857 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710421010858 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 710421010859 putative active site [active] 710421010860 putative catalytic site [active] 710421010861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421010862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421010863 active site 710421010864 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710421010865 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421010866 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 710421010867 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 710421010868 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710421010869 carboxyltransferase (CT) interaction site; other site 710421010870 biotinylation site [posttranslational modification]; other site 710421010871 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710421010872 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421010873 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421010874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421010875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421010876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421010877 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421010878 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710421010879 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 710421010880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421010881 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421010882 classical (c) SDRs; Region: SDR_c; cd05233 710421010883 NAD(P) binding site [chemical binding]; other site 710421010884 active site 710421010885 Domain of unknown function DUF87; Region: DUF87; pfam01935 710421010886 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 710421010887 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 710421010888 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 710421010889 catalytic site [active] 710421010890 putative active site [active] 710421010891 putative substrate binding site [chemical binding]; other site 710421010892 dimer interface [polypeptide binding]; other site 710421010893 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421010894 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 710421010895 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 710421010896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 710421010897 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 710421010898 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 710421010899 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 710421010900 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421010901 catalytic triad [active] 710421010902 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 710421010903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421010904 Beta-Casp domain; Region: Beta-Casp; smart01027 710421010905 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710421010906 hypothetical protein; Provisional; Region: PRK07907 710421010907 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 710421010908 active site 710421010909 metal binding site [ion binding]; metal-binding site 710421010910 dimer interface [polypeptide binding]; other site 710421010911 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 710421010912 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710421010913 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 710421010914 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710421010915 phosphate binding site [ion binding]; other site 710421010916 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 710421010917 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 710421010918 putative active site [active] 710421010919 putative catalytic site [active] 710421010920 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 710421010921 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710421010922 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 710421010923 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 710421010924 putative NAD(P) binding site [chemical binding]; other site 710421010925 active site 710421010926 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 710421010927 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 710421010928 active site 710421010929 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 710421010930 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 710421010931 DNA binding residues [nucleotide binding] 710421010932 putative dimer interface [polypeptide binding]; other site 710421010933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421010934 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421010935 putative substrate translocation pore; other site 710421010936 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 710421010937 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 710421010938 substrate binding site; other site 710421010939 dimer interface; other site 710421010940 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421010941 active site 710421010942 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710421010943 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421010944 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710421010945 acyl-activating enzyme (AAE) consensus motif; other site 710421010946 acyl-activating enzyme (AAE) consensus motif; other site 710421010947 putative AMP binding site [chemical binding]; other site 710421010948 putative active site [active] 710421010949 putative CoA binding site [chemical binding]; other site 710421010950 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421010951 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421010952 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421010953 acyl-activating enzyme (AAE) consensus motif; other site 710421010954 AMP binding site [chemical binding]; other site 710421010955 active site 710421010956 CoA binding site [chemical binding]; other site 710421010957 enoyl-CoA hydratase; Provisional; Region: PRK05870 710421010958 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421010959 substrate binding site [chemical binding]; other site 710421010960 oxyanion hole (OAH) forming residues; other site 710421010961 trimer interface [polypeptide binding]; other site 710421010962 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710421010963 dimer interface [polypeptide binding]; other site 710421010964 substrate binding site [chemical binding]; other site 710421010965 metal binding site [ion binding]; metal-binding site 710421010966 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710421010967 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710421010968 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421010969 lipid-transfer protein; Provisional; Region: PRK06059 710421010970 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421010971 active site 710421010972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421010973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421010974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421010975 Cytochrome P450; Region: p450; cl12078 710421010976 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421010977 mce related protein; Region: MCE; pfam02470 710421010978 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421010979 mce related protein; Region: MCE; pfam02470 710421010980 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421010981 mce related protein; Region: MCE; pfam02470 710421010982 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421010983 mce related protein; Region: MCE; pfam02470 710421010984 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421010985 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421010986 mce related protein; Region: MCE; pfam02470 710421010987 gag-polypeptide of LTR copia-type; Region: UBN2; cl15874 710421010988 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421010989 mce related protein; Region: MCE; pfam02470 710421010990 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421010991 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421010992 Permease; Region: Permease; pfam02405 710421010993 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421010994 Permease; Region: Permease; pfam02405 710421010995 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 710421010996 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421010997 active site 710421010998 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710421010999 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421011000 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421011001 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421011002 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710421011003 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710421011004 NAD binding site [chemical binding]; other site 710421011005 catalytic residues [active] 710421011006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421011007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011008 NAD(P) binding site [chemical binding]; other site 710421011009 active site 710421011010 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421011011 classical (c) SDRs; Region: SDR_c; cd05233 710421011012 NAD(P) binding site [chemical binding]; other site 710421011013 active site 710421011014 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 710421011015 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421011016 Cytochrome P450; Region: p450; cl12078 710421011017 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 710421011018 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 710421011019 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710421011020 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421011021 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011023 active site 710421011024 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011025 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421011026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011027 active site 710421011028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421011029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421011030 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710421011031 iron-sulfur cluster [ion binding]; other site 710421011032 [2Fe-2S] cluster binding site [ion binding]; other site 710421011033 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421011034 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 710421011035 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 710421011036 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710421011037 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421011038 lipid-transfer protein; Provisional; Region: PRK07855 710421011039 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421011040 active site 710421011041 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 710421011042 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421011043 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421011044 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710421011045 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 710421011046 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421011047 Cytochrome P450; Region: p450; cl12078 710421011048 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421011049 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710421011050 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710421011051 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421011052 Cytochrome P450; Region: p450; cl12078 710421011053 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 710421011054 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421011055 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 710421011056 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710421011057 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710421011058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421011059 Cytochrome P450; Region: p450; cl12078 710421011060 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 710421011061 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 710421011062 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421011063 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421011064 [2Fe-2S] cluster binding site [ion binding]; other site 710421011065 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710421011066 alpha subunit interface [polypeptide binding]; other site 710421011067 active site 710421011068 substrate binding site [chemical binding]; other site 710421011069 Fe binding site [ion binding]; other site 710421011070 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421011071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011072 NAD(P) binding site [chemical binding]; other site 710421011073 active site 710421011074 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 710421011075 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 710421011076 FAD binding pocket [chemical binding]; other site 710421011077 FAD binding motif [chemical binding]; other site 710421011078 phosphate binding motif [ion binding]; other site 710421011079 beta-alpha-beta structure motif; other site 710421011080 NAD(p) ribose binding residues [chemical binding]; other site 710421011081 NAD binding pocket [chemical binding]; other site 710421011082 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 710421011083 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421011084 catalytic loop [active] 710421011085 iron binding site [ion binding]; other site 710421011086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710421011087 MarR family; Region: MarR_2; pfam12802 710421011088 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710421011089 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710421011090 active site 710421011091 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421011092 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421011093 [2Fe-2S] cluster binding site [ion binding]; other site 710421011094 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710421011095 alpha subunit interface [polypeptide binding]; other site 710421011096 active site 710421011097 substrate binding site [chemical binding]; other site 710421011098 Fe binding site [ion binding]; other site 710421011099 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 710421011100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421011101 NAD binding site [chemical binding]; other site 710421011102 catalytic residues [active] 710421011103 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710421011104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011107 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 710421011108 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011110 active site 710421011111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011112 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421011113 NAD(P) binding site [chemical binding]; other site 710421011114 active site 710421011115 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710421011116 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421011117 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421011118 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421011119 active site 710421011120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011124 active site 710421011125 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710421011126 Phosphotransferase enzyme family; Region: APH; pfam01636 710421011127 putative active site [active] 710421011128 putative substrate binding site [chemical binding]; other site 710421011129 ATP binding site [chemical binding]; other site 710421011130 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 710421011131 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710421011132 NAD(P) binding site [chemical binding]; other site 710421011133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011136 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011137 active site 710421011138 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710421011139 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421011140 dimer interface [polypeptide binding]; other site 710421011141 active site 710421011142 enoyl-CoA hydratase; Provisional; Region: PRK06688 710421011143 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421011144 substrate binding site [chemical binding]; other site 710421011145 oxyanion hole (OAH) forming residues; other site 710421011146 trimer interface [polypeptide binding]; other site 710421011147 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421011148 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421011149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011151 active site 710421011152 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421011153 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710421011154 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710421011155 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421011156 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421011157 [2Fe-2S] cluster binding site [ion binding]; other site 710421011158 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 710421011159 alpha subunit interface [polypeptide binding]; other site 710421011160 active site 710421011161 substrate binding site [chemical binding]; other site 710421011162 Fe binding site [ion binding]; other site 710421011163 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710421011164 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421011165 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710421011166 active site 710421011167 SnoaL-like domain; Region: SnoaL_4; pfam13577 710421011168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011170 active site 710421011171 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011173 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710421011174 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421011175 Integrase core domain; Region: rve; pfam00665 710421011176 enoyl-CoA hydratase; Provisional; Region: PRK08290 710421011177 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421011178 substrate binding site [chemical binding]; other site 710421011179 oxyanion hole (OAH) forming residues; other site 710421011180 trimer interface [polypeptide binding]; other site 710421011181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011183 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421011184 Cytochrome P450; Region: p450; cl12078 710421011185 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421011186 classical (c) SDRs; Region: SDR_c; cd05233 710421011187 NAD(P) binding site [chemical binding]; other site 710421011188 active site 710421011189 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710421011190 Phosphotransferase enzyme family; Region: APH; pfam01636 710421011191 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421011192 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421011193 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710421011194 acyl-CoA synthetase; Provisional; Region: PRK13382 710421011195 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421011196 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421011197 acyl-activating enzyme (AAE) consensus motif; other site 710421011198 putative AMP binding site [chemical binding]; other site 710421011199 putative active site [active] 710421011200 putative CoA binding site [chemical binding]; other site 710421011201 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421011202 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710421011203 putative acyl-acceptor binding pocket; other site 710421011204 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 710421011205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011207 NAD(P) binding site [chemical binding]; other site 710421011208 active site 710421011209 classical (c) SDRs; Region: SDR_c; cd05233 710421011210 NAD(P) binding site [chemical binding]; other site 710421011211 active site 710421011212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011214 short chain dehydrogenase; Provisional; Region: PRK12827 710421011215 classical (c) SDRs; Region: SDR_c; cd05233 710421011216 NAD(P) binding site [chemical binding]; other site 710421011217 active site 710421011218 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 710421011219 classical (c) SDRs; Region: SDR_c; cd05233 710421011220 NAD(P) binding site [chemical binding]; other site 710421011221 active site 710421011222 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710421011223 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 710421011224 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 710421011225 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421011226 NAD(P) binding site [chemical binding]; other site 710421011227 catalytic residues [active] 710421011228 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421011229 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421011230 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421011231 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421011232 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421011233 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 710421011234 substrate binding site [chemical binding]; other site 710421011235 oxyanion hole (OAH) forming residues; other site 710421011236 trimer interface [polypeptide binding]; other site 710421011237 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710421011238 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710421011239 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710421011240 active site 710421011241 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710421011242 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710421011243 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 710421011244 active site 710421011245 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421011246 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421011247 Cytochrome P450; Region: p450; cl12078 710421011248 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710421011249 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710421011250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011252 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710421011253 classical (c) SDRs; Region: SDR_c; cd05233 710421011254 NAD(P) binding site [chemical binding]; other site 710421011255 active site 710421011256 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421011257 Predicted flavoprotein [General function prediction only]; Region: COG0431 710421011258 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710421011259 Putative cyclase; Region: Cyclase; pfam04199 710421011260 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421011261 NAD(P) binding site [chemical binding]; other site 710421011262 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 710421011263 active site 710421011264 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710421011265 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 710421011266 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 710421011267 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421011268 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 710421011269 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 710421011270 active site 710421011271 metal binding site [ion binding]; metal-binding site 710421011272 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 710421011273 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421011274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421011275 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421011276 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 710421011277 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710421011278 putative succinate dehydrogenase; Reviewed; Region: PRK12842 710421011279 Predicted oxidoreductase [General function prediction only]; Region: COG3573 710421011280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011281 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 710421011282 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 710421011283 Walker A; other site 710421011284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011285 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710421011286 NAD(P) binding site [chemical binding]; other site 710421011287 active site 710421011288 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 710421011289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011290 NAD(P) binding site [chemical binding]; other site 710421011291 active site 710421011292 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421011293 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421011294 substrate binding site [chemical binding]; other site 710421011295 oxyanion hole (OAH) forming residues; other site 710421011296 trimer interface [polypeptide binding]; other site 710421011297 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011299 active site 710421011300 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011301 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011302 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421011303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421011304 acyl-activating enzyme (AAE) consensus motif; other site 710421011305 AMP binding site [chemical binding]; other site 710421011306 active site 710421011307 CoA binding site [chemical binding]; other site 710421011308 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421011309 catalytic loop [active] 710421011310 iron binding site [ion binding]; other site 710421011311 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421011312 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421011313 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 710421011314 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421011315 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 710421011316 B12 binding site [chemical binding]; other site 710421011317 cobalt ligand [ion binding]; other site 710421011318 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 710421011319 short chain dehydrogenase; Provisional; Region: PRK08278 710421011320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011321 NAD(P) binding site [chemical binding]; other site 710421011322 active site 710421011323 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421011324 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421011325 acyl-activating enzyme (AAE) consensus motif; other site 710421011326 AMP binding site [chemical binding]; other site 710421011327 active site 710421011328 CoA binding site [chemical binding]; other site 710421011329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421011330 dimerization interface [polypeptide binding]; other site 710421011331 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421011332 cyclase homology domain; Region: CHD; cd07302 710421011333 nucleotidyl binding site; other site 710421011334 metal binding site [ion binding]; metal-binding site 710421011335 dimer interface [polypeptide binding]; other site 710421011336 metabolite-proton symporter; Region: 2A0106; TIGR00883 710421011337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421011338 putative substrate translocation pore; other site 710421011339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011340 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710421011341 NAD(P) binding site [chemical binding]; other site 710421011342 active site 710421011343 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 710421011344 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 710421011345 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421011346 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 710421011347 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421011348 active site 710421011349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011350 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421011351 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011352 active site 710421011353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011355 active site 710421011356 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710421011357 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 710421011358 putative NADP binding site [chemical binding]; other site 710421011359 putative substrate binding site [chemical binding]; other site 710421011360 active site 710421011361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011363 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 710421011364 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710421011365 Sulfatase; Region: Sulfatase; pfam00884 710421011366 Amidohydrolase; Region: Amidohydro_2; pfam04909 710421011367 Cupin domain; Region: Cupin_2; cl17218 710421011368 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421011369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421011370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421011371 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421011372 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710421011373 Glucitol operon activator protein (GutM); Region: GutM; cl01890 710421011374 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 710421011375 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710421011376 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 710421011377 active site 710421011378 dimerization interface [polypeptide binding]; other site 710421011379 ribonuclease PH; Reviewed; Region: rph; PRK00173 710421011380 Ribonuclease PH; Region: RNase_PH_bact; cd11362 710421011381 hexamer interface [polypeptide binding]; other site 710421011382 active site 710421011383 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 710421011384 glutamate racemase; Provisional; Region: PRK00865 710421011385 Rhomboid family; Region: Rhomboid; pfam01694 710421011386 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710421011387 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710421011388 dimer interface [polypeptide binding]; other site 710421011389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421011390 catalytic residue [active] 710421011391 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 710421011392 MoaE interaction surface [polypeptide binding]; other site 710421011393 MoeB interaction surface [polypeptide binding]; other site 710421011394 thiocarboxylated glycine; other site 710421011395 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 710421011396 MPN+ (JAMM) motif; other site 710421011397 Zinc-binding site [ion binding]; other site 710421011398 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 710421011399 putative active site pocket [active] 710421011400 cleavage site 710421011401 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 710421011402 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 710421011403 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 710421011404 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 710421011405 active site 710421011406 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 710421011407 DEAD/DEAH box helicase; Region: DEAD; pfam00270 710421011408 ATP binding site [chemical binding]; other site 710421011409 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 710421011410 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 710421011411 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 710421011412 Zn binding site [ion binding]; other site 710421011413 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 710421011414 putative homodimer interface [polypeptide binding]; other site 710421011415 putative active site pocket [active] 710421011416 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 710421011417 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 710421011418 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 710421011419 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 710421011420 active site 710421011421 homodimer interface [polypeptide binding]; other site 710421011422 catalytic site [active] 710421011423 acceptor binding site [chemical binding]; other site 710421011424 glycogen branching enzyme; Provisional; Region: PRK05402 710421011425 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 710421011426 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 710421011427 active site 710421011428 catalytic site [active] 710421011429 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 710421011430 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 710421011431 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 710421011432 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 710421011433 putative acyltransferase; Provisional; Region: PRK05790 710421011434 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421011435 dimer interface [polypeptide binding]; other site 710421011436 active site 710421011437 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 710421011438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421011439 dimer interface [polypeptide binding]; other site 710421011440 substrate binding site [chemical binding]; other site 710421011441 metal binding site [ion binding]; metal-binding site 710421011442 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 710421011443 hypothetical protein; Provisional; Region: PRK03298 710421011444 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421011445 dimerization interface [polypeptide binding]; other site 710421011446 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421011447 cyclase homology domain; Region: CHD; cd07302 710421011448 nucleotidyl binding site; other site 710421011449 metal binding site [ion binding]; metal-binding site 710421011450 dimer interface [polypeptide binding]; other site 710421011451 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011452 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421011453 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421011454 active site 710421011455 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421011456 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421011457 active site 710421011458 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421011459 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421011460 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421011461 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421011462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710421011463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421011464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 710421011465 dimerization interface [polypeptide binding]; other site 710421011466 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710421011467 active site 710421011468 metal binding site [ion binding]; metal-binding site 710421011469 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 710421011470 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 710421011471 AlkA N-terminal domain; Region: AlkA_N; pfam06029 710421011472 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 710421011473 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710421011474 minor groove reading motif; other site 710421011475 helix-hairpin-helix signature motif; other site 710421011476 substrate binding pocket [chemical binding]; other site 710421011477 active site 710421011478 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 710421011479 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 710421011480 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 710421011481 DNA binding site [nucleotide binding] 710421011482 active site 710421011483 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 710421011484 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 710421011485 hinge; other site 710421011486 active site 710421011487 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 710421011488 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 710421011489 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 710421011490 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 710421011491 gamma subunit interface [polypeptide binding]; other site 710421011492 epsilon subunit interface [polypeptide binding]; other site 710421011493 LBP interface [polypeptide binding]; other site 710421011494 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 710421011495 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710421011496 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 710421011497 alpha subunit interaction interface [polypeptide binding]; other site 710421011498 Walker A motif; other site 710421011499 ATP binding site [chemical binding]; other site 710421011500 Walker B motif; other site 710421011501 inhibitor binding site; inhibition site 710421011502 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710421011503 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 710421011504 core domain interface [polypeptide binding]; other site 710421011505 delta subunit interface [polypeptide binding]; other site 710421011506 epsilon subunit interface [polypeptide binding]; other site 710421011507 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 710421011508 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710421011509 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 710421011510 beta subunit interaction interface [polypeptide binding]; other site 710421011511 Walker A motif; other site 710421011512 ATP binding site [chemical binding]; other site 710421011513 Walker B motif; other site 710421011514 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710421011515 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 710421011516 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 710421011517 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 710421011518 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 710421011519 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 710421011520 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 710421011521 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 710421011522 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 710421011523 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 710421011524 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 710421011525 Mg++ binding site [ion binding]; other site 710421011526 putative catalytic motif [active] 710421011527 substrate binding site [chemical binding]; other site 710421011528 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 710421011529 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 710421011530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710421011531 peptide chain release factor 1; Validated; Region: prfA; PRK00591 710421011532 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710421011533 RF-1 domain; Region: RF-1; pfam00472 710421011534 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 710421011535 acyl-CoA synthetase; Provisional; Region: PRK13388 710421011536 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421011537 acyl-activating enzyme (AAE) consensus motif; other site 710421011538 AMP binding site [chemical binding]; other site 710421011539 active site 710421011540 CoA binding site [chemical binding]; other site 710421011541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011543 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421011544 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421011545 MarR family; Region: MarR; pfam01047 710421011546 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 710421011547 transcription termination factor Rho; Provisional; Region: PRK12608 710421011548 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710421011549 RNA binding site [nucleotide binding]; other site 710421011550 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 710421011551 multimer interface [polypeptide binding]; other site 710421011552 Walker A motif; other site 710421011553 ATP binding site [chemical binding]; other site 710421011554 Walker B motif; other site 710421011555 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 710421011556 threonine synthase; Reviewed; Region: PRK06721 710421011557 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 710421011558 homodimer interface [polypeptide binding]; other site 710421011559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421011560 catalytic residue [active] 710421011561 homoserine dehydrogenase; Provisional; Region: PRK06349 710421011562 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 710421011563 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 710421011564 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 710421011565 diaminopimelate decarboxylase; Region: lysA; TIGR01048 710421011566 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 710421011567 active site 710421011568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710421011569 substrate binding site [chemical binding]; other site 710421011570 catalytic residues [active] 710421011571 dimer interface [polypeptide binding]; other site 710421011572 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 710421011573 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 710421011574 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 710421011575 active site 710421011576 HIGH motif; other site 710421011577 KMSK motif region; other site 710421011578 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 710421011579 tRNA binding surface [nucleotide binding]; other site 710421011580 anticodon binding site; other site 710421011581 hypothetical protein; Provisional; Region: PRK07588 710421011582 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421011583 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 710421011584 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710421011585 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710421011586 catalytic residue [active] 710421011587 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 710421011588 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710421011589 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710421011590 FAD binding site [chemical binding]; other site 710421011591 substrate binding site [chemical binding]; other site 710421011592 catalytic base [active] 710421011593 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 710421011594 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421011595 active site 710421011596 TrkA-N domain; Region: TrkA_N; pfam02254 710421011597 Ion channel; Region: Ion_trans_2; pfam07885 710421011598 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710421011599 TrkA-N domain; Region: TrkA_N; pfam02254 710421011600 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710421011601 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 710421011602 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710421011603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421011604 DNA-binding site [nucleotide binding]; DNA binding site 710421011605 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 710421011606 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 710421011607 gating phenylalanine in ion channel; other site 710421011608 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710421011609 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421011610 Integrase core domain; Region: rve; pfam00665 710421011611 Nitronate monooxygenase; Region: NMO; pfam03060 710421011612 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710421011613 FMN binding site [chemical binding]; other site 710421011614 substrate binding site [chemical binding]; other site 710421011615 putative catalytic residue [active] 710421011616 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 710421011617 metal binding site [ion binding]; metal-binding site 710421011618 Rrf2 family protein; Region: rrf2_super; TIGR00738 710421011619 Transcriptional regulator; Region: Rrf2; pfam02082 710421011620 Isochorismatase family; Region: Isochorismatase; pfam00857 710421011621 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 710421011622 catalytic triad [active] 710421011623 conserved cis-peptide bond; other site 710421011624 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 710421011625 active site 710421011626 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 710421011627 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 710421011628 CysD dimerization site [polypeptide binding]; other site 710421011629 G1 box; other site 710421011630 putative GEF interaction site [polypeptide binding]; other site 710421011631 GTP/Mg2+ binding site [chemical binding]; other site 710421011632 Switch I region; other site 710421011633 G2 box; other site 710421011634 G3 box; other site 710421011635 Switch II region; other site 710421011636 G4 box; other site 710421011637 G5 box; other site 710421011638 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 710421011639 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 710421011640 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 710421011641 ligand-binding site [chemical binding]; other site 710421011642 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 710421011643 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 710421011644 Active Sites [active] 710421011645 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710421011646 putative active site [active] 710421011647 Phosphotransferase enzyme family; Region: APH; pfam01636 710421011648 ATP binding site [chemical binding]; other site 710421011649 putative substrate binding site [chemical binding]; other site 710421011650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011652 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421011653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421011654 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421011655 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710421011656 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 710421011657 Ligand binding site; other site 710421011658 Ligand binding site; other site 710421011659 Ligand binding site; other site 710421011660 Putative Catalytic site; other site 710421011661 DXD motif; other site 710421011662 GtrA-like protein; Region: GtrA; pfam04138 710421011663 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 710421011664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421011665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421011666 dimerization interface [polypeptide binding]; other site 710421011667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421011668 dimer interface [polypeptide binding]; other site 710421011669 phosphorylation site [posttranslational modification] 710421011670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421011671 ATP binding site [chemical binding]; other site 710421011672 Mg2+ binding site [ion binding]; other site 710421011673 G-X-G motif; other site 710421011674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421011675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421011676 active site 710421011677 phosphorylation site [posttranslational modification] 710421011678 intermolecular recognition site; other site 710421011679 dimerization interface [polypeptide binding]; other site 710421011680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421011681 DNA binding site [nucleotide binding] 710421011682 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710421011683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421011684 ABC-ATPase subunit interface; other site 710421011685 putative PBP binding loops; other site 710421011686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710421011687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421011688 dimer interface [polypeptide binding]; other site 710421011689 conserved gate region; other site 710421011690 putative PBP binding loops; other site 710421011691 ABC-ATPase subunit interface; other site 710421011692 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 710421011693 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710421011694 Walker A/P-loop; other site 710421011695 ATP binding site [chemical binding]; other site 710421011696 Q-loop/lid; other site 710421011697 ABC transporter signature motif; other site 710421011698 Walker B; other site 710421011699 D-loop; other site 710421011700 H-loop/switch region; other site 710421011701 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710421011702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710421011703 Walker A/P-loop; other site 710421011704 ATP binding site [chemical binding]; other site 710421011705 Q-loop/lid; other site 710421011706 ABC transporter signature motif; other site 710421011707 Walker B; other site 710421011708 D-loop; other site 710421011709 H-loop/switch region; other site 710421011710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710421011711 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 710421011712 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710421011713 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421011714 choline dehydrogenase; Validated; Region: PRK02106 710421011715 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710421011716 AAA domain; Region: AAA_23; pfam13476 710421011717 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 710421011718 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 710421011719 active site 710421011720 metal binding site [ion binding]; metal-binding site 710421011721 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421011722 catalytic core [active] 710421011723 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710421011724 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 710421011725 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710421011726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710421011727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421011728 Walker A/P-loop; other site 710421011729 ATP binding site [chemical binding]; other site 710421011730 Q-loop/lid; other site 710421011731 ABC transporter signature motif; other site 710421011732 Walker B; other site 710421011733 D-loop; other site 710421011734 H-loop/switch region; other site 710421011735 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710421011736 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 710421011737 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 710421011738 Walker A/P-loop; other site 710421011739 ATP binding site [chemical binding]; other site 710421011740 Q-loop/lid; other site 710421011741 ABC transporter signature motif; other site 710421011742 Walker B; other site 710421011743 D-loop; other site 710421011744 H-loop/switch region; other site 710421011745 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710421011746 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421011747 molybdopterin cofactor binding site; other site 710421011748 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 710421011749 molybdopterin cofactor binding site; other site 710421011750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421011751 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421011752 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 710421011753 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 710421011754 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 710421011755 putative active site [active] 710421011756 dimerization interface [polypeptide binding]; other site 710421011757 putative tRNAtyr binding site [nucleotide binding]; other site 710421011758 Domain of unknown function (DUF305); Region: DUF305; pfam03713 710421011759 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710421011760 metal-binding site [ion binding] 710421011761 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 710421011762 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 710421011763 metal-binding site [ion binding] 710421011764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421011765 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421011766 cyclase homology domain; Region: CHD; cd07302 710421011767 nucleotidyl binding site; other site 710421011768 metal binding site [ion binding]; metal-binding site 710421011769 dimer interface [polypeptide binding]; other site 710421011770 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 710421011771 putative active site [active] 710421011772 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421011773 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710421011774 putative dimer interface [polypeptide binding]; other site 710421011775 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421011776 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 710421011777 HIT family signature motif; other site 710421011778 catalytic residue [active] 710421011779 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710421011780 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 710421011781 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 710421011782 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 710421011783 Fe-S cluster binding site [ion binding]; other site 710421011784 DNA binding site [nucleotide binding] 710421011785 active site 710421011786 H+ Antiporter protein; Region: 2A0121; TIGR00900 710421011787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421011788 FAD binding domain; Region: FAD_binding_4; pfam01565 710421011789 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 710421011790 Helix-turn-helix domain; Region: HTH_28; pfam13518 710421011791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421011792 Integrase core domain; Region: rve; pfam00665 710421011793 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710421011794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421011795 Walker A motif; other site 710421011796 ATP binding site [chemical binding]; other site 710421011797 Walker B motif; other site 710421011798 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710421011799 Abi-like protein; Region: Abi_2; pfam07751 710421011800 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421011801 Cytochrome P450; Region: p450; cl12078 710421011802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421011803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421011804 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 710421011805 Acyltransferase family; Region: Acyl_transf_3; pfam01757 710421011806 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 710421011807 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 710421011808 ATP binding site [chemical binding]; other site 710421011809 Mg++ binding site [ion binding]; other site 710421011810 motif III; other site 710421011811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421011812 nucleotide binding region [chemical binding]; other site 710421011813 ATP-binding site [chemical binding]; other site 710421011814 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 710421011815 putative RNA binding site [nucleotide binding]; other site 710421011816 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 710421011817 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 710421011818 RNase_H superfamily; Region: RNase_H_2; pfam13482 710421011819 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710421011820 Part of AAA domain; Region: AAA_19; pfam13245 710421011821 AAA domain; Region: AAA_12; pfam13087 710421011822 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710421011823 FAD binding domain; Region: FAD_binding_4; pfam01565 710421011824 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421011825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421011826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421011827 putative substrate translocation pore; other site 710421011828 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 710421011829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421011830 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 710421011831 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710421011832 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 710421011833 TPP-binding site [chemical binding]; other site 710421011834 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 710421011835 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710421011836 short chain dehydrogenase; Provisional; Region: PRK07832 710421011837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421011838 NAD(P) binding site [chemical binding]; other site 710421011839 active site 710421011840 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 710421011841 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 710421011842 Malic enzyme, N-terminal domain; Region: malic; pfam00390 710421011843 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 710421011844 putative NAD(P) binding site [chemical binding]; other site 710421011845 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 710421011846 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 710421011847 oligomer interface [polypeptide binding]; other site 710421011848 metal binding site [ion binding]; metal-binding site 710421011849 metal binding site [ion binding]; metal-binding site 710421011850 putative Cl binding site [ion binding]; other site 710421011851 basic sphincter; other site 710421011852 hydrophobic gate; other site 710421011853 periplasmic entrance; other site 710421011854 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 710421011855 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710421011856 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710421011857 Walker A/P-loop; other site 710421011858 ATP binding site [chemical binding]; other site 710421011859 Q-loop/lid; other site 710421011860 ABC transporter signature motif; other site 710421011861 Walker B; other site 710421011862 D-loop; other site 710421011863 H-loop/switch region; other site 710421011864 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 710421011865 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 710421011866 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 710421011867 PRC-barrel domain; Region: PRC; pfam05239 710421011868 MgtE intracellular N domain; Region: MgtE_N; smart00924 710421011869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 710421011870 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 710421011871 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 710421011872 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710421011873 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710421011874 Domain of unknown function DUF59; Region: DUF59; cl00941 710421011875 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 710421011876 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 710421011877 sec-independent translocase; Provisional; Region: PRK03100 710421011878 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710421011879 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710421011880 protein binding site [polypeptide binding]; other site 710421011881 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 710421011882 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 710421011883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421011884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421011885 DNA binding residues [nucleotide binding] 710421011886 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 710421011887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421011888 S-adenosylmethionine binding site [chemical binding]; other site 710421011889 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710421011890 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710421011891 Walker A/P-loop; other site 710421011892 ATP binding site [chemical binding]; other site 710421011893 Q-loop/lid; other site 710421011894 ABC transporter signature motif; other site 710421011895 Walker B; other site 710421011896 D-loop; other site 710421011897 H-loop/switch region; other site 710421011898 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 710421011899 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 710421011900 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 710421011901 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710421011902 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 710421011903 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 710421011904 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 710421011905 ligand binding site; other site 710421011906 oligomer interface; other site 710421011907 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 710421011908 dimer interface [polypeptide binding]; other site 710421011909 N-terminal domain interface [polypeptide binding]; other site 710421011910 sulfate 1 binding site; other site 710421011911 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 710421011912 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421011913 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 710421011914 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421011915 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 710421011916 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 710421011917 DivIVA domain; Region: DivI1A_domain; TIGR03544 710421011918 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 710421011919 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710421011920 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 710421011921 dihydropteroate synthase; Region: DHPS; TIGR01496 710421011922 substrate binding pocket [chemical binding]; other site 710421011923 dimer interface [polypeptide binding]; other site 710421011924 inhibitor binding site; inhibition site 710421011925 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 710421011926 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 710421011927 acyl-activating enzyme (AAE) consensus motif; other site 710421011928 putative AMP binding site [chemical binding]; other site 710421011929 putative active site [active] 710421011930 putative CoA binding site [chemical binding]; other site 710421011931 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 710421011932 AAA domain; Region: AAA_22; pfam13401 710421011933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421011934 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 710421011935 Walker A/P-loop; other site 710421011936 ATP binding site [chemical binding]; other site 710421011937 Q-loop/lid; other site 710421011938 ABC transporter signature motif; other site 710421011939 Walker B; other site 710421011940 D-loop; other site 710421011941 H-loop/switch region; other site 710421011942 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 710421011943 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 710421011944 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 710421011945 metal binding site [ion binding]; metal-binding site 710421011946 putative dimer interface [polypeptide binding]; other site 710421011947 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 710421011948 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 710421011949 homodimer interface [polypeptide binding]; other site 710421011950 substrate-cofactor binding pocket; other site 710421011951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421011952 catalytic residue [active] 710421011953 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710421011954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710421011955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421011956 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 710421011957 dimerization interface [polypeptide binding]; other site 710421011958 substrate binding pocket [chemical binding]; other site 710421011959 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 710421011960 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 710421011961 putative trimer interface [polypeptide binding]; other site 710421011962 putative CoA binding site [chemical binding]; other site 710421011963 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 710421011964 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710421011965 active site 710421011966 acyl-CoA synthetase; Validated; Region: PRK07787 710421011967 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421011968 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421011969 acyl-activating enzyme (AAE) consensus motif; other site 710421011970 acyl-activating enzyme (AAE) consensus motif; other site 710421011971 AMP binding site [chemical binding]; other site 710421011972 active site 710421011973 CoA binding site [chemical binding]; other site 710421011974 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 710421011975 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 710421011976 dimer interface [polypeptide binding]; other site 710421011977 active site 710421011978 ADP-ribose binding site [chemical binding]; other site 710421011979 nudix motif; other site 710421011980 metal binding site [ion binding]; metal-binding site 710421011981 Proline dehydrogenase; Region: Pro_dh; cl03282 710421011982 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 710421011983 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 710421011984 Glutamate binding site [chemical binding]; other site 710421011985 NAD binding site [chemical binding]; other site 710421011986 catalytic residues [active] 710421011987 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421011988 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 710421011989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421011990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421011991 homodimer interface [polypeptide binding]; other site 710421011992 catalytic residue [active] 710421011993 Ferredoxin [Energy production and conversion]; Region: COG1146 710421011994 4Fe-4S binding domain; Region: Fer4; pfam00037 710421011995 Uncharacterized conserved protein [Function unknown]; Region: COG2353 710421011996 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 710421011997 FO synthase; Reviewed; Region: fbiC; PRK09234 710421011998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421011999 FeS/SAM binding site; other site 710421012000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421012001 FeS/SAM binding site; other site 710421012002 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 710421012003 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 710421012004 Cl- selectivity filter; other site 710421012005 Cl- binding residues [ion binding]; other site 710421012006 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 710421012007 pore gating glutamate residue; other site 710421012008 dimer interface [polypeptide binding]; other site 710421012009 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 710421012010 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 710421012011 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710421012012 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 710421012013 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 710421012014 G1 box; other site 710421012015 putative GEF interaction site [polypeptide binding]; other site 710421012016 GTP/Mg2+ binding site [chemical binding]; other site 710421012017 Switch I region; other site 710421012018 G2 box; other site 710421012019 G3 box; other site 710421012020 Switch II region; other site 710421012021 G4 box; other site 710421012022 G5 box; other site 710421012023 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 710421012024 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 710421012025 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 710421012026 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 710421012027 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 710421012028 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 710421012029 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 710421012030 [4Fe-4S] binding site [ion binding]; other site 710421012031 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421012032 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421012033 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421012034 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 710421012035 molybdopterin cofactor binding site; other site 710421012036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421012037 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 710421012038 putative substrate translocation pore; other site 710421012039 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 710421012040 active site 710421012041 8-oxo-dGMP binding site [chemical binding]; other site 710421012042 nudix motif; other site 710421012043 metal binding site [ion binding]; metal-binding site 710421012044 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 710421012045 aromatic arch; other site 710421012046 DCoH dimer interaction site [polypeptide binding]; other site 710421012047 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 710421012048 DCoH tetramer interaction site [polypeptide binding]; other site 710421012049 substrate binding site [chemical binding]; other site 710421012050 mannosyltransferase; Provisional; Region: pimE; PRK13375 710421012051 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 710421012052 FMN binding site [chemical binding]; other site 710421012053 Nitroreductase family; Region: Nitroreductase; pfam00881 710421012054 dimer interface [polypeptide binding]; other site 710421012055 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 710421012056 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710421012057 Presynaptic Site I dimer interface [polypeptide binding]; other site 710421012058 catalytic residues [active] 710421012059 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 710421012060 Synaptic Flat tetramer interface [polypeptide binding]; other site 710421012061 Synaptic Site I dimer interface [polypeptide binding]; other site 710421012062 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 710421012063 minor groove reading motif; other site 710421012064 helix-hairpin-helix signature motif; other site 710421012065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421012066 S-adenosylmethionine binding site [chemical binding]; other site 710421012067 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710421012068 active site residue [active] 710421012069 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710421012070 catalytic residues [active] 710421012071 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 710421012072 Rhodanese-like domain; Region: Rhodanese; pfam00581 710421012073 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421012074 active site residue [active] 710421012075 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421012076 active site residue [active] 710421012077 Histidine kinase; Region: His_kinase; pfam06580 710421012078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421012079 ATP binding site [chemical binding]; other site 710421012080 Mg2+ binding site [ion binding]; other site 710421012081 G-X-G motif; other site 710421012082 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 710421012083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421012084 active site 710421012085 phosphorylation site [posttranslational modification] 710421012086 intermolecular recognition site; other site 710421012087 dimerization interface [polypeptide binding]; other site 710421012088 LytTr DNA-binding domain; Region: LytTR; smart00850 710421012089 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710421012090 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 710421012091 Na binding site [ion binding]; other site 710421012092 Protein of unknown function, DUF485; Region: DUF485; pfam04341 710421012093 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 710421012094 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 710421012095 Na binding site [ion binding]; other site 710421012096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421012097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421012098 putative substrate translocation pore; other site 710421012099 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421012100 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421012101 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710421012102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 710421012103 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 710421012104 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 710421012105 Predicted transcriptional regulators [Transcription]; Region: COG1725 710421012106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421012107 DNA-binding site [nucleotide binding]; DNA binding site 710421012108 NAD-dependent deacetylase; Provisional; Region: PRK00481 710421012109 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 710421012110 NAD+ binding site [chemical binding]; other site 710421012111 substrate binding site [chemical binding]; other site 710421012112 Zn binding site [ion binding]; other site 710421012113 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710421012114 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710421012115 S-adenosylmethionine binding site [chemical binding]; other site 710421012116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421012117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421012118 WHG domain; Region: WHG; pfam13305 710421012119 MMPL family; Region: MMPL; pfam03176 710421012120 MMPL family; Region: MMPL; pfam03176 710421012121 Predicted membrane protein [Function unknown]; Region: COG2259 710421012122 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 710421012123 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710421012124 FMN binding site [chemical binding]; other site 710421012125 substrate binding site [chemical binding]; other site 710421012126 putative catalytic residue [active] 710421012127 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 710421012128 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 710421012129 NAD binding site [chemical binding]; other site 710421012130 homodimer interface [polypeptide binding]; other site 710421012131 homotetramer interface [polypeptide binding]; other site 710421012132 active site 710421012133 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421012134 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421012135 enoyl-CoA hydratase; Provisional; Region: PRK06688 710421012136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421012137 substrate binding site [chemical binding]; other site 710421012138 oxyanion hole (OAH) forming residues; other site 710421012139 trimer interface [polypeptide binding]; other site 710421012140 CAAX protease self-immunity; Region: Abi; pfam02517 710421012141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421012142 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710421012143 NAD(P) binding site [chemical binding]; other site 710421012144 active site 710421012145 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 710421012146 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 710421012147 trimer interface [polypeptide binding]; other site 710421012148 putative metal binding site [ion binding]; other site 710421012149 oxidoreductase; Provisional; Region: PRK06196 710421012150 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710421012151 putative NAD(P) binding site [chemical binding]; other site 710421012152 active site 710421012153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421012154 Fasciclin domain; Region: Fasciclin; pfam02469 710421012155 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421012156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421012157 active site 710421012158 enoyl-CoA hydratase; Provisional; Region: PRK08252 710421012159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421012160 substrate binding site [chemical binding]; other site 710421012161 oxyanion hole (OAH) forming residues; other site 710421012162 trimer interface [polypeptide binding]; other site 710421012163 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710421012164 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421012165 dimer interface [polypeptide binding]; other site 710421012166 active site 710421012167 Transcriptional regulators [Transcription]; Region: FadR; COG2186 710421012168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421012169 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 710421012170 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 710421012171 Predicted membrane protein [Function unknown]; Region: COG2259 710421012172 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421012173 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421012174 classical (c) SDRs; Region: SDR_c; cd05233 710421012175 NAD(P) binding site [chemical binding]; other site 710421012176 active site 710421012177 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421012178 mce related protein; Region: MCE; pfam02470 710421012179 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421012180 mce related protein; Region: MCE; pfam02470 710421012181 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421012182 mce related protein; Region: MCE; pfam02470 710421012183 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421012184 mce related protein; Region: MCE; pfam02470 710421012185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 710421012186 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421012187 mce related protein; Region: MCE; pfam02470 710421012188 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421012189 mce related protein; Region: MCE; pfam02470 710421012190 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421012191 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421012192 Permease; Region: Permease; pfam02405 710421012193 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421012194 Permease; Region: Permease; pfam02405 710421012195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421012196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421012197 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421012198 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421012199 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710421012200 hypothetical protein; Provisional; Region: PRK06149 710421012201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710421012202 active site 710421012203 ATP binding site [chemical binding]; other site 710421012204 substrate binding site [chemical binding]; other site 710421012205 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421012206 inhibitor-cofactor binding pocket; inhibition site 710421012207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421012208 catalytic residue [active] 710421012209 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421012210 cyclase homology domain; Region: CHD; cd07302 710421012211 nucleotidyl binding site; other site 710421012212 metal binding site [ion binding]; metal-binding site 710421012213 dimer interface [polypeptide binding]; other site 710421012214 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 710421012215 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 710421012216 Methyltransferase domain; Region: Methyltransf_23; pfam13489 710421012217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421012218 S-adenosylmethionine binding site [chemical binding]; other site 710421012219 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710421012220 RibD C-terminal domain; Region: RibD_C; cl17279 710421012221 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710421012222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421012223 dimerization interface [polypeptide binding]; other site 710421012224 putative DNA binding site [nucleotide binding]; other site 710421012225 putative Zn2+ binding site [ion binding]; other site 710421012226 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 710421012227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421012228 putative metal binding site [ion binding]; other site 710421012229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421012230 dimerization interface [polypeptide binding]; other site 710421012231 putative DNA binding site [nucleotide binding]; other site 710421012232 putative Zn2+ binding site [ion binding]; other site 710421012233 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 710421012234 arsenical-resistance protein; Region: acr3; TIGR00832 710421012235 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710421012236 Low molecular weight phosphatase family; Region: LMWPc; cd00115 710421012237 active site 710421012238 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 710421012239 Low molecular weight phosphatase family; Region: LMWPc; cl00105 710421012240 active site 710421012241 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 710421012242 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710421012243 P loop; other site 710421012244 Nucleotide binding site [chemical binding]; other site 710421012245 DTAP/Switch II; other site 710421012246 Switch I; other site 710421012247 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710421012248 DTAP/Switch II; other site 710421012249 Switch I; other site 710421012250 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421012251 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710421012252 active site 710421012253 metal binding site [ion binding]; metal-binding site 710421012254 Methyltransferase domain; Region: Methyltransf_11; pfam08241 710421012255 GTP-binding protein YchF; Reviewed; Region: PRK09601 710421012256 YchF GTPase; Region: YchF; cd01900 710421012257 G1 box; other site 710421012258 GTP/Mg2+ binding site [chemical binding]; other site 710421012259 Switch I region; other site 710421012260 G2 box; other site 710421012261 Switch II region; other site 710421012262 G3 box; other site 710421012263 G4 box; other site 710421012264 G5 box; other site 710421012265 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 710421012266 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 710421012267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710421012268 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 710421012269 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 710421012270 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 710421012271 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 710421012272 generic binding surface II; other site 710421012273 generic binding surface I; other site 710421012274 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 710421012275 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 710421012276 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 710421012277 putative NAD(P) binding site [chemical binding]; other site 710421012278 active site 710421012279 putative substrate binding site [chemical binding]; other site 710421012280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421012281 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 710421012282 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 710421012283 Sulfatase; Region: Sulfatase; pfam00884 710421012284 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 710421012285 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 710421012286 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710421012287 Uncharacterized conserved protein [Function unknown]; Region: COG1262 710421012288 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421012289 hydrophobic ligand binding site; other site 710421012290 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421012291 classical (c) SDRs; Region: SDR_c; cd05233 710421012292 NAD(P) binding site [chemical binding]; other site 710421012293 active site 710421012294 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421012295 classical (c) SDRs; Region: SDR_c; cd05233 710421012296 NAD(P) binding site [chemical binding]; other site 710421012297 active site 710421012298 Domain of unknown function DUF20; Region: UPF0118; pfam01594 710421012299 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 710421012300 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710421012301 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 710421012302 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 710421012303 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 710421012304 putative active site [active] 710421012305 fumarate hydratase; Reviewed; Region: fumC; PRK00485 710421012306 Class II fumarases; Region: Fumarase_classII; cd01362 710421012307 active site 710421012308 tetramer interface [polypeptide binding]; other site 710421012309 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710421012310 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 710421012311 NodB motif; other site 710421012312 active site 710421012313 catalytic site [active] 710421012314 metal binding site [ion binding]; metal-binding site 710421012315 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 710421012316 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 710421012317 putative active site [active] 710421012318 PhoH-like protein; Region: PhoH; pfam02562 710421012319 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710421012320 dinuclear metal binding motif [ion binding]; other site 710421012321 serine hydroxymethyltransferase; Provisional; Region: PRK13580 710421012322 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 710421012323 dimer interface [polypeptide binding]; other site 710421012324 active site 710421012325 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710421012326 folate binding site [chemical binding]; other site 710421012327 pantothenate kinase; Provisional; Region: PRK05439 710421012328 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 710421012329 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 710421012330 Zn binding site [ion binding]; other site 710421012331 ATP-binding site [chemical binding]; other site 710421012332 CoA-binding site [chemical binding]; other site 710421012333 Mg2+-binding site [ion binding]; other site 710421012334 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 710421012335 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 710421012336 catalytic residue [active] 710421012337 putative FPP diphosphate binding site; other site 710421012338 putative FPP binding hydrophobic cleft; other site 710421012339 dimer interface [polypeptide binding]; other site 710421012340 putative IPP diphosphate binding site; other site 710421012341 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 710421012342 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 710421012343 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710421012344 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 710421012345 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 710421012346 catalytic residues [active] 710421012347 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 710421012348 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 710421012349 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710421012350 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 710421012351 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710421012352 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 710421012353 cystathionine gamma-synthase; Provisional; Region: PRK07811 710421012354 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 710421012355 homodimer interface [polypeptide binding]; other site 710421012356 substrate-cofactor binding pocket; other site 710421012357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421012358 catalytic residue [active] 710421012359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421012360 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421012361 active site 710421012362 RDD family; Region: RDD; pfam06271 710421012363 RDD family; Region: RDD; pfam06271 710421012364 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 710421012365 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 710421012366 dimer interface [polypeptide binding]; other site 710421012367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421012368 catalytic residue [active] 710421012369 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 710421012370 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 710421012371 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 710421012372 substrate binding pocket [chemical binding]; other site 710421012373 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 710421012374 active site 710421012375 catalytic triad [active] 710421012376 oxyanion hole [active] 710421012377 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 710421012378 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421012379 dimer interface [polypeptide binding]; other site 710421012380 active site 710421012381 Bax inhibitor 1 like; Region: BaxI_1; cl17691 710421012382 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 710421012383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421012384 substrate binding site [chemical binding]; other site 710421012385 oxyanion hole (OAH) forming residues; other site 710421012386 trimer interface [polypeptide binding]; other site 710421012387 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 710421012388 enoyl-CoA hydratase; Provisional; Region: PRK05862 710421012389 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421012390 substrate binding site [chemical binding]; other site 710421012391 oxyanion hole (OAH) forming residues; other site 710421012392 trimer interface [polypeptide binding]; other site 710421012393 Predicted membrane protein [Function unknown]; Region: COG4425 710421012394 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710421012395 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 710421012396 active site residue [active] 710421012397 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 710421012398 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 710421012399 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 710421012400 active site 710421012401 nucleophile elbow; other site 710421012402 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 710421012403 nucleophile elbow; other site 710421012404 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 710421012405 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421012406 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710421012407 lipid-transfer protein; Provisional; Region: PRK08256 710421012408 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421012409 active site 710421012410 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 710421012411 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 710421012412 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 710421012413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421012414 ATP binding site [chemical binding]; other site 710421012415 Mg2+ binding site [ion binding]; other site 710421012416 G-X-G motif; other site 710421012417 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 710421012418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421012419 active site 710421012420 phosphorylation site [posttranslational modification] 710421012421 intermolecular recognition site; other site 710421012422 dimerization interface [polypeptide binding]; other site 710421012423 HTH domain; Region: HTH_11; cl17392 710421012424 Uncharacterized conserved protein [Function unknown]; Region: COG3391 710421012425 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 710421012426 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421012427 anti sigma factor interaction site; other site 710421012428 regulatory phosphorylation site [posttranslational modification]; other site 710421012429 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421012430 anti sigma factor interaction site; other site 710421012431 regulatory phosphorylation site [posttranslational modification]; other site 710421012432 GAF domain; Region: GAF; cl17456 710421012433 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710421012434 B12 binding domain; Region: B12-binding_2; pfam02607 710421012435 B12 binding domain; Region: B12-binding; pfam02310 710421012436 B12 binding site [chemical binding]; other site 710421012437 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421012438 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421012439 Predicted membrane protein [Function unknown]; Region: COG2119 710421012440 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 710421012441 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 710421012442 yybP-ykoY leader; Mycch_4118; IMG reference gene:2506873250 710421012443 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710421012444 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 710421012445 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 710421012446 Cl- selectivity filter; other site 710421012447 Cl- binding residues [ion binding]; other site 710421012448 pore gating glutamate residue; other site 710421012449 dimer interface [polypeptide binding]; other site 710421012450 H+/Cl- coupling transport residue; other site 710421012451 Domain of unknown function (DUF427); Region: DUF427; cl00998 710421012452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 710421012453 PE-PPE domain; Region: PE-PPE; pfam08237 710421012454 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421012455 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421012456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 710421012457 MOSC domain; Region: MOSC; pfam03473 710421012458 3-alpha domain; Region: 3-alpha; pfam03475 710421012459 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 710421012460 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710421012461 FAD binding pocket [chemical binding]; other site 710421012462 FAD binding motif [chemical binding]; other site 710421012463 phosphate binding motif [ion binding]; other site 710421012464 beta-alpha-beta structure motif; other site 710421012465 NAD binding pocket [chemical binding]; other site 710421012466 Heme binding pocket [chemical binding]; other site 710421012467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421012468 catalytic loop [active] 710421012469 iron binding site [ion binding]; other site 710421012470 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 710421012471 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421012472 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 710421012473 E-class dimer interface [polypeptide binding]; other site 710421012474 P-class dimer interface [polypeptide binding]; other site 710421012475 active site 710421012476 Cu2+ binding site [ion binding]; other site 710421012477 Zn2+ binding site [ion binding]; other site 710421012478 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710421012479 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710421012480 Walker A/P-loop; other site 710421012481 ATP binding site [chemical binding]; other site 710421012482 Q-loop/lid; other site 710421012483 ABC transporter signature motif; other site 710421012484 Walker B; other site 710421012485 D-loop; other site 710421012486 H-loop/switch region; other site 710421012487 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421012488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421012489 substrate binding pocket [chemical binding]; other site 710421012490 membrane-bound complex binding site; other site 710421012491 hinge residues; other site 710421012492 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710421012493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421012494 dimer interface [polypeptide binding]; other site 710421012495 conserved gate region; other site 710421012496 putative PBP binding loops; other site 710421012497 ABC-ATPase subunit interface; other site 710421012498 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710421012499 Amino acid permease; Region: AA_permease_2; pfam13520 710421012500 Spore germination protein; Region: Spore_permease; cl17796 710421012501 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421012502 Ligand Binding Site [chemical binding]; other site 710421012503 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421012504 Ligand Binding Site [chemical binding]; other site 710421012505 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 710421012506 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 710421012507 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710421012508 metal binding site [ion binding]; metal-binding site 710421012509 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 710421012510 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 710421012511 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 710421012512 TrkA-N domain; Region: TrkA_N; pfam02254 710421012513 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710421012514 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710421012515 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421012516 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 710421012517 DXD motif; other site 710421012518 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 710421012519 putative active site [active] 710421012520 putative metal binding site [ion binding]; other site 710421012521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421012522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421012523 hypothetical protein; Provisional; Region: PRK07588 710421012524 hypothetical protein; Provisional; Region: PRK07236 710421012525 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421012526 Cytochrome P450; Region: p450; cl12078 710421012527 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 710421012528 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 710421012529 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 710421012530 active site 710421012531 DNA binding site [nucleotide binding] 710421012532 Int/Topo IB signature motif; other site 710421012533 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 710421012534 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421012535 NAD binding site [chemical binding]; other site 710421012536 catalytic Zn binding site [ion binding]; other site 710421012537 structural Zn binding site [ion binding]; other site 710421012538 Hemerythrin-like domain; Region: Hr-like; cd12108 710421012539 Fe binding site [ion binding]; other site 710421012540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421012541 short chain dehydrogenase; Provisional; Region: PRK06701 710421012542 NAD(P) binding site [chemical binding]; other site 710421012543 active site 710421012544 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 710421012545 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 710421012546 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 710421012547 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 710421012548 Ligand Binding Site [chemical binding]; other site 710421012549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421012550 dimer interface [polypeptide binding]; other site 710421012551 phosphorylation site [posttranslational modification] 710421012552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421012553 ATP binding site [chemical binding]; other site 710421012554 Mg2+ binding site [ion binding]; other site 710421012555 G-X-G motif; other site 710421012556 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 710421012557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421012558 active site 710421012559 phosphorylation site [posttranslational modification] 710421012560 intermolecular recognition site; other site 710421012561 dimerization interface [polypeptide binding]; other site 710421012562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421012563 DNA binding site [nucleotide binding] 710421012564 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421012565 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 710421012566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421012567 acyl-activating enzyme (AAE) consensus motif; other site 710421012568 AMP binding site [chemical binding]; other site 710421012569 active site 710421012570 CoA binding site [chemical binding]; other site 710421012571 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 710421012572 exopolyphosphatase; Region: exo_poly_only; TIGR03706 710421012573 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 710421012574 Uncharacterized conserved protein [Function unknown]; Region: COG1507 710421012575 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 710421012576 Septum formation initiator; Region: DivIC; pfam04977 710421012577 enolase; Provisional; Region: eno; PRK00077 710421012578 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 710421012579 dimer interface [polypeptide binding]; other site 710421012580 metal binding site [ion binding]; metal-binding site 710421012581 substrate binding pocket [chemical binding]; other site 710421012582 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421012583 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421012584 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 710421012585 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 710421012586 N-acetyl-D-glucosamine binding site [chemical binding]; other site 710421012587 Iron permease FTR1 family; Region: FTR1; cl00475 710421012588 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 710421012589 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 710421012590 Imelysin; Region: Peptidase_M75; pfam09375 710421012591 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 710421012592 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 710421012593 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 710421012594 homodimer interface [polypeptide binding]; other site 710421012595 metal binding site [ion binding]; metal-binding site 710421012596 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 710421012597 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 710421012598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421012599 ATP binding site [chemical binding]; other site 710421012600 putative Mg++ binding site [ion binding]; other site 710421012601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421012602 nucleotide binding region [chemical binding]; other site 710421012603 ATP-binding site [chemical binding]; other site 710421012604 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 710421012605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421012606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421012607 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421012608 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710421012609 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421012610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421012611 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710421012612 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 710421012613 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 710421012614 Substrate binding site; other site 710421012615 Mg++ binding site; other site 710421012616 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 710421012617 active site 710421012618 substrate binding site [chemical binding]; other site 710421012619 CoA binding site [chemical binding]; other site 710421012620 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 710421012621 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 710421012622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421012623 active site 710421012624 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 710421012625 ArsC family; Region: ArsC; pfam03960 710421012626 catalytic residues [active] 710421012627 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710421012628 short chain dehydrogenase; Provisional; Region: PRK06197 710421012629 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 710421012630 putative NAD(P) binding site [chemical binding]; other site 710421012631 active site 710421012632 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 710421012633 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 710421012634 5S rRNA interface [nucleotide binding]; other site 710421012635 CTC domain interface [polypeptide binding]; other site 710421012636 L16 interface [polypeptide binding]; other site 710421012637 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 710421012638 putative active site [active] 710421012639 catalytic residue [active] 710421012640 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 710421012641 4Fe-4S binding domain; Region: Fer4; pfam00037 710421012642 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710421012643 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421012644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421012645 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 710421012646 Walker A/P-loop; other site 710421012647 ATP binding site [chemical binding]; other site 710421012648 Q-loop/lid; other site 710421012649 ABC transporter signature motif; other site 710421012650 Walker B; other site 710421012651 D-loop; other site 710421012652 H-loop/switch region; other site 710421012653 Lipase maturation factor; Region: LMF1; pfam06762 710421012654 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 710421012655 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421012656 acyl-activating enzyme (AAE) consensus motif; other site 710421012657 AMP binding site [chemical binding]; other site 710421012658 active site 710421012659 CoA binding site [chemical binding]; other site 710421012660 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 710421012661 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 710421012662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421012663 S-adenosylmethionine binding site [chemical binding]; other site 710421012664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 710421012665 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710421012666 Domain of unknown function (DUF348); Region: DUF348; pfam03990 710421012667 G5 domain; Region: G5; pfam07501 710421012668 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710421012669 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 710421012670 active site 710421012671 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 710421012672 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 710421012673 active site 710421012674 HIGH motif; other site 710421012675 KMSKS motif; other site 710421012676 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710421012677 tRNA binding surface [nucleotide binding]; other site 710421012678 anticodon binding site; other site 710421012679 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710421012680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421012681 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 710421012682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421012683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421012684 DNA binding residues [nucleotide binding] 710421012685 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 710421012686 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 710421012687 chorismate binding enzyme; Region: Chorismate_bind; cl10555 710421012688 Predicted methyltransferases [General function prediction only]; Region: COG0313 710421012689 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 710421012690 putative SAM binding site [chemical binding]; other site 710421012691 putative homodimer interface [polypeptide binding]; other site 710421012692 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 710421012693 arginine deiminase; Provisional; Region: PRK01388 710421012694 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 710421012695 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 710421012696 DNA binding residues [nucleotide binding] 710421012697 dimer interface [polypeptide binding]; other site 710421012698 [2Fe-2S] cluster binding site [ion binding]; other site 710421012699 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 710421012700 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710421012701 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 710421012702 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 710421012703 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 710421012704 shikimate binding site; other site 710421012705 NAD(P) binding site [chemical binding]; other site 710421012706 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710421012707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710421012708 ligand binding site [chemical binding]; other site 710421012709 flexible hinge region; other site 710421012710 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710421012711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421012712 Coenzyme A binding pocket [chemical binding]; other site 710421012713 Cupin domain; Region: Cupin_2; cl17218 710421012714 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 710421012715 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710421012716 MarR family; Region: MarR; pfam01047 710421012717 PE-PPE domain; Region: PE-PPE; pfam08237 710421012718 NACHT domain; Region: NACHT; pfam05729 710421012719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710421012720 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 710421012721 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 710421012722 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 710421012723 dimer interface [polypeptide binding]; other site 710421012724 putative functional site; other site 710421012725 putative MPT binding site; other site 710421012726 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 710421012727 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 710421012728 active site 710421012729 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 710421012730 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 710421012731 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 710421012732 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 710421012733 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 710421012734 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 710421012735 MspA; Region: MspA; pfam09203 710421012736 MspA; Region: MspA; pfam09203 710421012737 MspA; Region: MspA; pfam09203 710421012738 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 710421012739 MPT binding site; other site 710421012740 trimer interface [polypeptide binding]; other site 710421012741 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710421012742 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710421012743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421012744 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421012745 dimerization interface [polypeptide binding]; other site 710421012746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421012747 dimer interface [polypeptide binding]; other site 710421012748 phosphorylation site [posttranslational modification] 710421012749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421012750 ATP binding site [chemical binding]; other site 710421012751 Mg2+ binding site [ion binding]; other site 710421012752 G-X-G motif; other site 710421012753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421012754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421012755 active site 710421012756 phosphorylation site [posttranslational modification] 710421012757 intermolecular recognition site; other site 710421012758 dimerization interface [polypeptide binding]; other site 710421012759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421012760 DNA binding site [nucleotide binding] 710421012761 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 710421012762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421012763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421012764 active site 710421012765 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710421012766 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421012767 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 710421012768 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 710421012769 ATP-grasp domain; Region: ATP-grasp_4; cl17255 710421012770 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 710421012771 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 710421012772 carboxyltransferase (CT) interaction site; other site 710421012773 biotinylation site [posttranslational modification]; other site 710421012774 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421012775 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421012776 active site 710421012777 enoyl-CoA hydratase; Provisional; Region: PRK07827 710421012778 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421012779 substrate binding site [chemical binding]; other site 710421012780 oxyanion hole (OAH) forming residues; other site 710421012781 trimer interface [polypeptide binding]; other site 710421012782 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710421012783 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 710421012784 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 710421012785 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 710421012786 metal ion-dependent adhesion site (MIDAS); other site 710421012787 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 710421012788 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 710421012789 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 710421012790 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 710421012791 purine monophosphate binding site [chemical binding]; other site 710421012792 dimer interface [polypeptide binding]; other site 710421012793 putative catalytic residues [active] 710421012794 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 710421012795 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 710421012796 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 710421012797 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 710421012798 active site 710421012799 cosubstrate binding site; other site 710421012800 substrate binding site [chemical binding]; other site 710421012801 catalytic site [active] 710421012802 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 710421012803 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 710421012804 dimer interface [polypeptide binding]; other site 710421012805 active site 710421012806 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710421012807 catalytic residues [active] 710421012808 substrate binding site [chemical binding]; other site 710421012809 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421012810 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421012811 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710421012812 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 710421012813 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421012814 active site 710421012815 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710421012816 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421012817 Integrase core domain; Region: rve; pfam00665 710421012818 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 710421012819 CoA binding domain; Region: CoA_binding; smart00881 710421012820 CoA-ligase; Region: Ligase_CoA; pfam00549 710421012821 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 710421012822 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 710421012823 CoA-ligase; Region: Ligase_CoA; pfam00549 710421012824 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 710421012825 Peptidase family M23; Region: Peptidase_M23; pfam01551 710421012826 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710421012827 hydrophobic ligand binding site; other site 710421012828 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421012829 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421012830 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 710421012831 Part of AAA domain; Region: AAA_19; pfam13245 710421012832 Family description; Region: UvrD_C_2; pfam13538 710421012833 Chorismate mutase type II; Region: CM_2; cl00693 710421012834 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 710421012835 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 710421012836 active site 710421012837 catalytic triad [active] 710421012838 oxyanion hole [active] 710421012839 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421012840 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 710421012841 tetramerization interface [polypeptide binding]; other site 710421012842 NAD(P) binding site [chemical binding]; other site 710421012843 catalytic residues [active] 710421012844 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 710421012845 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 710421012846 active site 710421012847 dimer interface [polypeptide binding]; other site 710421012848 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 710421012849 dimer interface [polypeptide binding]; other site 710421012850 active site 710421012851 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 710421012852 active site 710421012853 catalytic residues [active] 710421012854 short chain dehydrogenase; Provisional; Region: PRK08251 710421012855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421012856 NAD(P) binding site [chemical binding]; other site 710421012857 active site 710421012858 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710421012859 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 710421012860 putative DNA binding site [nucleotide binding]; other site 710421012861 catalytic residue [active] 710421012862 putative H2TH interface [polypeptide binding]; other site 710421012863 putative catalytic residues [active] 710421012864 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710421012865 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710421012866 Predicted membrane protein [Function unknown]; Region: COG1950 710421012867 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 710421012868 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421012869 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421012870 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 710421012871 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 710421012872 active site 710421012873 TDP-binding site; other site 710421012874 acceptor substrate-binding pocket; other site 710421012875 homodimer interface [polypeptide binding]; other site 710421012876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421012877 S-adenosylmethionine binding site [chemical binding]; other site 710421012878 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 710421012879 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 710421012880 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 710421012881 nucleotide binding site [chemical binding]; other site 710421012882 Entner-Doudoroff aldolase; Region: eda; TIGR01182 710421012883 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 710421012884 active site 710421012885 intersubunit interface [polypeptide binding]; other site 710421012886 catalytic residue [active] 710421012887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421012888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421012889 putative substrate translocation pore; other site 710421012890 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 710421012891 RNA/DNA hybrid binding site [nucleotide binding]; other site 710421012892 active site 710421012893 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421012894 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421012895 active site 710421012896 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 710421012897 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 710421012898 nucleotide binding site [chemical binding]; other site 710421012899 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 710421012900 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 710421012901 active site 710421012902 DNA binding site [nucleotide binding] 710421012903 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 710421012904 DNA binding site [nucleotide binding] 710421012905 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710421012906 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 710421012907 putative substrate binding site [chemical binding]; other site 710421012908 putative ATP binding site [chemical binding]; other site 710421012909 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 710421012910 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 710421012911 putative DNA binding site [nucleotide binding]; other site 710421012912 putative homodimer interface [polypeptide binding]; other site 710421012913 short chain dehydrogenase; Provisional; Region: PRK07814 710421012914 classical (c) SDRs; Region: SDR_c; cd05233 710421012915 NAD(P) binding site [chemical binding]; other site 710421012916 active site 710421012917 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 710421012918 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 710421012919 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 710421012920 putative active site pocket [active] 710421012921 dimerization interface [polypeptide binding]; other site 710421012922 putative catalytic residue [active] 710421012923 Protein of unknown function (DUF867); Region: DUF867; pfam05908 710421012924 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 710421012925 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 710421012926 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421012927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421012928 DNA binding residues [nucleotide binding] 710421012929 Anti-sigma-K factor rskA; Region: RskA; pfam10099 710421012930 carboxylate-amine ligase; Provisional; Region: PRK13517 710421012931 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 710421012932 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 710421012933 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421012934 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 710421012935 Subunit I/III interface [polypeptide binding]; other site 710421012936 Restriction endonuclease; Region: Mrr_cat; pfam04471 710421012937 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710421012938 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 710421012939 Helix-turn-helix domain; Region: HTH_28; pfam13518 710421012940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 710421012941 Integrase core domain; Region: rve; pfam00665 710421012942 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 710421012943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421012944 Walker A motif; other site 710421012945 ATP binding site [chemical binding]; other site 710421012946 Walker B motif; other site 710421012947 putative transposase OrfB; Reviewed; Region: PHA02517 710421012948 HTH-like domain; Region: HTH_21; pfam13276 710421012949 Integrase core domain; Region: rve; pfam00665 710421012950 Integrase core domain; Region: rve_3; cl15866 710421012951 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421012952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421012953 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421012954 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30_like; cl00203 710421012955 23S rRNA binding site - archaea [nucleotide binding]; other site 710421012956 23S rRNA binding site - prokaryotes [nucleotide binding]; other site 710421012957 5S rRNA binding site - archaea; other site 710421012958 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 710421012959 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 710421012960 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421012961 active site 710421012962 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 710421012963 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 710421012964 Predicted transcriptional regulators [Transcription]; Region: COG1733 710421012965 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710421012966 Predicted transcriptional regulators [Transcription]; Region: COG1733 710421012967 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 710421012968 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 710421012969 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 710421012970 putative dimer interface [polypeptide binding]; other site 710421012971 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 710421012972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710421012973 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 710421012974 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710421012975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710421012976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421012977 S-adenosylmethionine binding site [chemical binding]; other site 710421012978 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710421012979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421012980 S-adenosylmethionine binding site [chemical binding]; other site 710421012981 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 710421012982 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 710421012983 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710421012984 NAD binding site [chemical binding]; other site 710421012985 catalytic residues [active] 710421012986 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 710421012987 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710421012988 PYR/PP interface [polypeptide binding]; other site 710421012989 dimer interface [polypeptide binding]; other site 710421012990 TPP binding site [chemical binding]; other site 710421012991 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710421012992 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 710421012993 TPP-binding site; other site 710421012994 dimer interface [polypeptide binding]; other site 710421012995 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421012996 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 710421012997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421012998 active site 710421012999 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 710421013000 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013001 active site 710421013002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013005 active site 710421013006 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 710421013007 CoA-transferase family III; Region: CoA_transf_3; pfam02515 710421013008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013009 NAD(P) binding site [chemical binding]; other site 710421013010 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421013011 active site 710421013012 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421013013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421013014 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421013015 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421013016 [2Fe-2S] cluster binding site [ion binding]; other site 710421013017 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710421013018 hydrophobic ligand binding site; other site 710421013019 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 710421013020 classical (c) SDRs; Region: SDR_c; cd05233 710421013021 NAD(P) binding site [chemical binding]; other site 710421013022 active site 710421013023 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 710421013024 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710421013025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421013026 DNA-binding site [nucleotide binding]; DNA binding site 710421013027 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 710421013028 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421013029 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 710421013030 acyl-activating enzyme (AAE) consensus motif; other site 710421013031 putative AMP binding site [chemical binding]; other site 710421013032 putative active site [active] 710421013033 putative CoA binding site [chemical binding]; other site 710421013034 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 710421013035 classical (c) SDRs; Region: SDR_c; cd05233 710421013036 NAD(P) binding site [chemical binding]; other site 710421013037 active site 710421013038 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421013039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013040 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 710421013041 acyl-activating enzyme (AAE) consensus motif; other site 710421013042 acyl-activating enzyme (AAE) consensus motif; other site 710421013043 putative AMP binding site [chemical binding]; other site 710421013044 putative active site [active] 710421013045 putative CoA binding site [chemical binding]; other site 710421013046 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 710421013047 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 710421013048 active site 710421013049 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 710421013050 dimer interface [polypeptide binding]; other site 710421013051 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 710421013052 Ligand Binding Site [chemical binding]; other site 710421013053 Molecular Tunnel; other site 710421013054 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710421013055 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421013056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710421013057 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710421013058 Walker A/P-loop; other site 710421013059 ATP binding site [chemical binding]; other site 710421013060 Q-loop/lid; other site 710421013061 ABC transporter signature motif; other site 710421013062 Walker B; other site 710421013063 D-loop; other site 710421013064 H-loop/switch region; other site 710421013065 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 710421013066 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421013067 active site 710421013068 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421013069 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 710421013070 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 710421013071 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 710421013072 putative NADP binding site [chemical binding]; other site 710421013073 active site 710421013074 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421013075 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 710421013076 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 710421013077 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 710421013078 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421013079 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710421013080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421013081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013082 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 710421013083 metal ion-dependent adhesion site (MIDAS); other site 710421013084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421013085 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710421013086 Walker A motif; other site 710421013087 ATP binding site [chemical binding]; other site 710421013088 Walker B motif; other site 710421013089 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 710421013090 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421013091 Cytochrome P450; Region: p450; cl12078 710421013092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013093 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710421013094 NAD(P) binding site [chemical binding]; other site 710421013095 active site 710421013096 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421013097 hydrophobic ligand binding site; other site 710421013098 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 710421013099 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 710421013100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421013101 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 710421013102 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710421013103 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421013104 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421013105 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 710421013106 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710421013107 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 710421013108 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421013109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421013110 substrate binding site [chemical binding]; other site 710421013111 oxyanion hole (OAH) forming residues; other site 710421013112 trimer interface [polypeptide binding]; other site 710421013113 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 710421013114 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421013115 Predicted membrane protein [Function unknown]; Region: COG1511 710421013116 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 710421013117 Predicted membrane protein [Function unknown]; Region: COG1511 710421013118 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 710421013119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421013120 Walker A/P-loop; other site 710421013121 ATP binding site [chemical binding]; other site 710421013122 enoyl-CoA hydratase; Provisional; Region: PRK08260 710421013123 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421013124 substrate binding site [chemical binding]; other site 710421013125 oxyanion hole (OAH) forming residues; other site 710421013126 trimer interface [polypeptide binding]; other site 710421013127 Epoxide hydrolase N terminus; Region: EHN; pfam06441 710421013128 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421013129 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710421013130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710421013131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421013132 Walker A/P-loop; other site 710421013133 ATP binding site [chemical binding]; other site 710421013134 Q-loop/lid; other site 710421013135 ABC transporter signature motif; other site 710421013136 Walker B; other site 710421013137 D-loop; other site 710421013138 H-loop/switch region; other site 710421013139 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 710421013140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710421013141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421013142 Walker A/P-loop; other site 710421013143 ATP binding site [chemical binding]; other site 710421013144 Q-loop/lid; other site 710421013145 ABC transporter signature motif; other site 710421013146 Walker B; other site 710421013147 D-loop; other site 710421013148 H-loop/switch region; other site 710421013149 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710421013150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710421013151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421013152 Walker A/P-loop; other site 710421013153 ATP binding site [chemical binding]; other site 710421013154 Q-loop/lid; other site 710421013155 ABC transporter signature motif; other site 710421013156 Walker B; other site 710421013157 D-loop; other site 710421013158 H-loop/switch region; other site 710421013159 Ion channel; Region: Ion_trans_2; pfam07885 710421013160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421013161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421013162 active site 710421013163 phosphorylation site [posttranslational modification] 710421013164 intermolecular recognition site; other site 710421013165 dimerization interface [polypeptide binding]; other site 710421013166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421013167 DNA binding site [nucleotide binding] 710421013168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421013169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421013170 dimerization interface [polypeptide binding]; other site 710421013171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421013172 dimer interface [polypeptide binding]; other site 710421013173 phosphorylation site [posttranslational modification] 710421013174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421013175 ATP binding site [chemical binding]; other site 710421013176 Mg2+ binding site [ion binding]; other site 710421013177 G-X-G motif; other site 710421013178 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710421013179 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 710421013180 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710421013181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421013182 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710421013183 MarR family; Region: MarR_2; pfam12802 710421013184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 710421013185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421013186 putative substrate translocation pore; other site 710421013187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421013188 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 710421013189 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 710421013190 dimer interface [polypeptide binding]; other site 710421013191 active site 710421013192 citrylCoA binding site [chemical binding]; other site 710421013193 NADH binding [chemical binding]; other site 710421013194 cationic pore residues; other site 710421013195 oxalacetate/citrate binding site [chemical binding]; other site 710421013196 coenzyme A binding site [chemical binding]; other site 710421013197 catalytic triad [active] 710421013198 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710421013199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013200 enterobactin exporter EntS; Provisional; Region: PRK10489 710421013201 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 710421013202 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 710421013203 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 710421013204 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 710421013205 citrate synthase 2; Provisional; Region: PRK12350 710421013206 oxalacetate binding site [chemical binding]; other site 710421013207 citrylCoA binding site [chemical binding]; other site 710421013208 coenzyme A binding site [chemical binding]; other site 710421013209 catalytic triad [active] 710421013210 TIGR03086 family protein; Region: TIGR03086 710421013211 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421013212 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 710421013213 putative dimer interface [polypeptide binding]; other site 710421013214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421013215 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 710421013216 Ferredoxin [Energy production and conversion]; Region: COG1146 710421013217 4Fe-4S binding domain; Region: Fer4; pfam00037 710421013218 ferredoxin-NADP+ reductase; Region: PLN02852 710421013219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421013220 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 710421013221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421013222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421013223 catalytic residue [active] 710421013224 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 710421013225 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 710421013226 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710421013227 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710421013228 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 710421013229 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421013230 hydrophobic ligand binding site; other site 710421013231 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 710421013232 H+ Antiporter protein; Region: 2A0121; TIGR00900 710421013233 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 710421013234 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 710421013235 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 710421013236 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 710421013237 putative dimer interface [polypeptide binding]; other site 710421013238 N-terminal domain interface [polypeptide binding]; other site 710421013239 putative substrate binding pocket (H-site) [chemical binding]; other site 710421013240 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710421013241 DNA-binding site [nucleotide binding]; DNA binding site 710421013242 RNA-binding motif; other site 710421013243 hypothetical protein; Provisional; Region: PRK11770 710421013244 Domain of unknown function (DUF307); Region: DUF307; pfam03733 710421013245 Domain of unknown function (DUF307); Region: DUF307; pfam03733 710421013246 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 710421013247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710421013248 FeS/SAM binding site; other site 710421013249 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 710421013250 Ubiquitin-like proteins; Region: UBQ; cl00155 710421013251 charged pocket; other site 710421013252 hydrophobic patch; other site 710421013253 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 710421013254 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 710421013255 MoaD interaction [polypeptide binding]; other site 710421013256 active site residues [active] 710421013257 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 710421013258 MPT binding site; other site 710421013259 trimer interface [polypeptide binding]; other site 710421013260 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 710421013261 trimer interface [polypeptide binding]; other site 710421013262 dimer interface [polypeptide binding]; other site 710421013263 putative active site [active] 710421013264 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710421013265 WYL domain; Region: WYL; pfam13280 710421013266 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 710421013267 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 710421013268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710421013269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421013270 ATP binding site [chemical binding]; other site 710421013271 putative Mg++ binding site [ion binding]; other site 710421013272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421013273 nucleotide binding region [chemical binding]; other site 710421013274 ATP-binding site [chemical binding]; other site 710421013275 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421013276 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710421013277 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 710421013278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013280 AMP binding site [chemical binding]; other site 710421013281 active site 710421013282 acyl-activating enzyme (AAE) consensus motif; other site 710421013283 CoA binding site [chemical binding]; other site 710421013284 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 710421013285 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710421013286 conserved cys residue [active] 710421013287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421013288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421013289 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 710421013290 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421013291 substrate binding site [chemical binding]; other site 710421013292 oxyanion hole (OAH) forming residues; other site 710421013293 trimer interface [polypeptide binding]; other site 710421013294 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710421013295 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 710421013296 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 710421013297 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421013298 dimer interface [polypeptide binding]; other site 710421013299 active site 710421013300 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 710421013301 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 710421013302 FMN binding site [chemical binding]; other site 710421013303 active site 710421013304 substrate binding site [chemical binding]; other site 710421013305 catalytic residue [active] 710421013306 aminotransferase; Validated; Region: PRK07777 710421013307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421013308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421013309 homodimer interface [polypeptide binding]; other site 710421013310 catalytic residue [active] 710421013311 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710421013312 putative hydrophobic ligand binding site [chemical binding]; other site 710421013313 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 710421013314 Double zinc ribbon; Region: DZR; pfam12773 710421013315 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421013316 cyclase homology domain; Region: CHD; cd07302 710421013317 nucleotidyl binding site; other site 710421013318 metal binding site [ion binding]; metal-binding site 710421013319 dimer interface [polypeptide binding]; other site 710421013320 Predicted ATPase [General function prediction only]; Region: COG3899 710421013321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421013322 Walker A motif; other site 710421013323 ATP binding site [chemical binding]; other site 710421013324 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421013325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421013326 DNA binding residues [nucleotide binding] 710421013327 dimerization interface [polypeptide binding]; other site 710421013328 Cation efflux family; Region: Cation_efflux; cl00316 710421013329 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 710421013330 putative hydrophobic ligand binding site [chemical binding]; other site 710421013331 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 710421013332 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 710421013333 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 710421013334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013335 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421013336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421013337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013338 chorismate mutase; Provisional; Region: PRK09269 710421013339 Chorismate mutase type II; Region: CM_2; cl00693 710421013340 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421013341 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421013342 active site 710421013343 ATP binding site [chemical binding]; other site 710421013344 substrate binding site [chemical binding]; other site 710421013345 activation loop (A-loop); other site 710421013346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 710421013347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 710421013348 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 710421013349 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 710421013350 homodimer interface [polypeptide binding]; other site 710421013351 putative substrate binding pocket [chemical binding]; other site 710421013352 diiron center [ion binding]; other site 710421013353 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 710421013354 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 710421013355 FMN binding site [chemical binding]; other site 710421013356 active site 710421013357 catalytic residues [active] 710421013358 substrate binding site [chemical binding]; other site 710421013359 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 710421013360 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 710421013361 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710421013362 PhoU domain; Region: PhoU; pfam01895 710421013363 PhoU domain; Region: PhoU; pfam01895 710421013364 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 710421013365 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 710421013366 Walker A/P-loop; other site 710421013367 ATP binding site [chemical binding]; other site 710421013368 Q-loop/lid; other site 710421013369 ABC transporter signature motif; other site 710421013370 Walker B; other site 710421013371 D-loop; other site 710421013372 H-loop/switch region; other site 710421013373 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 710421013374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421013375 dimer interface [polypeptide binding]; other site 710421013376 conserved gate region; other site 710421013377 putative PBP binding loops; other site 710421013378 ABC-ATPase subunit interface; other site 710421013379 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 710421013380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421013381 dimer interface [polypeptide binding]; other site 710421013382 conserved gate region; other site 710421013383 putative PBP binding loops; other site 710421013384 ABC-ATPase subunit interface; other site 710421013385 PBP superfamily domain; Region: PBP_like_2; cl17296 710421013386 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 710421013387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 710421013388 Coenzyme A binding pocket [chemical binding]; other site 710421013389 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 710421013390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421013391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421013392 DNA binding site [nucleotide binding] 710421013393 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 710421013394 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710421013395 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421013396 catalytic residues [active] 710421013397 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 710421013398 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 710421013399 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 710421013400 active site residue [active] 710421013401 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 710421013402 active site residue [active] 710421013403 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 710421013404 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710421013405 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 710421013406 heme-binding site [chemical binding]; other site 710421013407 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 710421013408 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 710421013409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421013410 catalytic residue [active] 710421013411 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 710421013412 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 710421013413 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 710421013414 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 710421013415 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 710421013416 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 710421013417 dimerization interface [polypeptide binding]; other site 710421013418 putative ATP binding site [chemical binding]; other site 710421013419 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 710421013420 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710421013421 putative NAD(P) binding site [chemical binding]; other site 710421013422 putative active site [active] 710421013423 amidophosphoribosyltransferase; Provisional; Region: PRK07847 710421013424 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 710421013425 active site 710421013426 tetramer interface [polypeptide binding]; other site 710421013427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421013428 active site 710421013429 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421013430 mce related protein; Region: MCE; pfam02470 710421013431 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421013432 CAAX protease self-immunity; Region: Abi; pfam02517 710421013433 Predicted membrane protein [Function unknown]; Region: COG4425 710421013434 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 710421013435 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 710421013436 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 710421013437 dimerization interface [polypeptide binding]; other site 710421013438 ATP binding site [chemical binding]; other site 710421013439 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 710421013440 dimerization interface [polypeptide binding]; other site 710421013441 ATP binding site [chemical binding]; other site 710421013442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710421013443 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 710421013444 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 710421013445 active site 710421013446 metal binding site [ion binding]; metal-binding site 710421013447 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 710421013448 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 710421013449 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 710421013450 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 710421013451 putative active site [active] 710421013452 catalytic triad [active] 710421013453 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 710421013454 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710421013455 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710421013456 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421013457 FAD binding domain; Region: FAD_binding_2; pfam00890 710421013458 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 710421013459 Predicted deacetylase [General function prediction only]; Region: COG3233 710421013460 putative active site [active] 710421013461 putative Zn binding site [ion binding]; other site 710421013462 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 710421013463 catalytic residues [active] 710421013464 dimer interface [polypeptide binding]; other site 710421013465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421013466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013467 WHG domain; Region: WHG; pfam13305 710421013468 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 710421013469 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421013470 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 710421013471 ATP binding site [chemical binding]; other site 710421013472 active site 710421013473 substrate binding site [chemical binding]; other site 710421013474 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710421013475 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 710421013476 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 710421013477 gating phenylalanine in ion channel; other site 710421013478 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421013479 Cytochrome P450; Region: p450; cl12078 710421013480 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 710421013481 Lyase; Region: Lyase_1; pfam00206 710421013482 tetramer interface [polypeptide binding]; other site 710421013483 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 710421013484 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710421013485 synthetase active site [active] 710421013486 NTP binding site [chemical binding]; other site 710421013487 metal binding site [ion binding]; metal-binding site 710421013488 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710421013489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013490 NAD(P) binding site [chemical binding]; other site 710421013491 active site 710421013492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 710421013493 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 710421013494 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 710421013495 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 710421013496 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 710421013497 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 710421013498 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421013499 Cytochrome P450; Region: p450; cl12078 710421013500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013501 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 710421013502 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 710421013503 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 710421013504 short chain dehydrogenase; Provisional; Region: PRK07774 710421013505 classical (c) SDRs; Region: SDR_c; cd05233 710421013506 NAD(P) binding site [chemical binding]; other site 710421013507 active site 710421013508 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 710421013509 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 710421013510 NAD binding site [chemical binding]; other site 710421013511 catalytic residues [active] 710421013512 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421013513 Cytochrome P450; Region: p450; cl12078 710421013514 short chain dehydrogenase; Provisional; Region: PRK07775 710421013515 classical (c) SDRs; Region: SDR_c; cd05233 710421013516 NAD(P) binding site [chemical binding]; other site 710421013517 active site 710421013518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421013519 Cytochrome P450; Region: p450; cl12078 710421013520 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 710421013521 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 710421013522 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710421013523 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710421013524 NAD binding site [chemical binding]; other site 710421013525 catalytic Zn binding site [ion binding]; other site 710421013526 substrate binding site [chemical binding]; other site 710421013527 structural Zn binding site [ion binding]; other site 710421013528 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421013529 classical (c) SDRs; Region: SDR_c; cd05233 710421013530 short chain dehydrogenase; Provisional; Region: PRK07791 710421013531 NAD(P) binding site [chemical binding]; other site 710421013532 active site 710421013533 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 710421013534 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710421013535 dimer interface [polypeptide binding]; other site 710421013536 acyl-activating enzyme (AAE) consensus motif; other site 710421013537 putative active site [active] 710421013538 AMP binding site [chemical binding]; other site 710421013539 putative CoA binding site [chemical binding]; other site 710421013540 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 710421013541 nucleotide binding site/active site [active] 710421013542 HIT family signature motif; other site 710421013543 catalytic residue [active] 710421013544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 710421013545 HAMP domain; Region: HAMP; pfam00672 710421013546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 710421013547 dimer interface [polypeptide binding]; other site 710421013548 phosphorylation site [posttranslational modification] 710421013549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710421013550 ATP binding site [chemical binding]; other site 710421013551 Mg2+ binding site [ion binding]; other site 710421013552 G-X-G motif; other site 710421013553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 710421013554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421013555 active site 710421013556 phosphorylation site [posttranslational modification] 710421013557 intermolecular recognition site; other site 710421013558 dimerization interface [polypeptide binding]; other site 710421013559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 710421013560 DNA binding site [nucleotide binding] 710421013561 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710421013562 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710421013563 Walker A/P-loop; other site 710421013564 ATP binding site [chemical binding]; other site 710421013565 Q-loop/lid; other site 710421013566 ABC transporter signature motif; other site 710421013567 Walker B; other site 710421013568 D-loop; other site 710421013569 H-loop/switch region; other site 710421013570 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 710421013571 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 710421013572 FtsX-like permease family; Region: FtsX; pfam02687 710421013573 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 710421013574 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710421013575 FAD binding domain; Region: FAD_binding_4; pfam01565 710421013576 Berberine and berberine like; Region: BBE; pfam08031 710421013577 AAA ATPase domain; Region: AAA_16; pfam13191 710421013578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421013579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421013580 DNA binding residues [nucleotide binding] 710421013581 dimerization interface [polypeptide binding]; other site 710421013582 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 710421013583 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710421013584 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 710421013585 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 710421013586 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 710421013587 XdhC Rossmann domain; Region: XdhC_C; pfam13478 710421013588 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 710421013589 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 710421013590 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 710421013591 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 710421013592 putative hydrophobic ligand binding site [chemical binding]; other site 710421013593 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 710421013594 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 710421013595 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 710421013596 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421013597 catalytic loop [active] 710421013598 iron binding site [ion binding]; other site 710421013599 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 710421013600 short chain dehydrogenase; Provisional; Region: PRK05875 710421013601 classical (c) SDRs; Region: SDR_c; cd05233 710421013602 NAD(P) binding site [chemical binding]; other site 710421013603 active site 710421013604 enoyl-CoA hydratase; Provisional; Region: PRK08290 710421013605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421013606 substrate binding site [chemical binding]; other site 710421013607 oxyanion hole (OAH) forming residues; other site 710421013608 trimer interface [polypeptide binding]; other site 710421013609 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 710421013610 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 710421013611 active site 710421013612 homotetramer interface [polypeptide binding]; other site 710421013613 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 710421013614 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421013615 mce related protein; Region: MCE; pfam02470 710421013616 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421013617 mce related protein; Region: MCE; pfam02470 710421013618 mce related protein; Region: MCE; pfam02470 710421013619 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421013620 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421013621 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421013622 mce related protein; Region: MCE; pfam02470 710421013623 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 710421013624 mce related protein; Region: MCE; pfam02470 710421013625 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421013626 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421013627 mce related protein; Region: MCE; pfam02470 710421013628 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 710421013629 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421013630 Permease; Region: Permease; pfam02405 710421013631 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 710421013632 Permease; Region: Permease; pfam02405 710421013633 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 710421013634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013635 NAD(P) binding site [chemical binding]; other site 710421013636 active site 710421013637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013638 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 710421013639 FAD binding site [chemical binding]; other site 710421013640 substrate binding site [chemical binding]; other site 710421013641 catalytic base [active] 710421013642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013643 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421013644 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 710421013645 active site 710421013646 acyl-CoA synthetase; Validated; Region: PRK07867 710421013647 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013648 acyl-activating enzyme (AAE) consensus motif; other site 710421013649 AMP binding site [chemical binding]; other site 710421013650 active site 710421013651 CoA binding site [chemical binding]; other site 710421013652 acyl-CoA synthetase; Provisional; Region: PRK13388 710421013653 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013654 acyl-activating enzyme (AAE) consensus motif; other site 710421013655 AMP binding site [chemical binding]; other site 710421013656 active site 710421013657 CoA binding site [chemical binding]; other site 710421013658 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 710421013659 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421013660 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421013661 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 710421013662 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421013663 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421013664 active site 710421013665 Transposase; Region: DEDD_Tnp_IS110; pfam01548 710421013666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 710421013667 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 710421013668 hypothetical protein; Validated; Region: PRK07586 710421013669 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 710421013670 PYR/PP interface [polypeptide binding]; other site 710421013671 dimer interface [polypeptide binding]; other site 710421013672 TPP binding site [chemical binding]; other site 710421013673 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 710421013674 TPP-binding site [chemical binding]; other site 710421013675 dimer interface [polypeptide binding]; other site 710421013676 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 710421013677 Nitronate monooxygenase; Region: NMO; pfam03060 710421013678 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710421013679 FMN binding site [chemical binding]; other site 710421013680 substrate binding site [chemical binding]; other site 710421013681 putative catalytic residue [active] 710421013682 acyl-CoA synthetase; Validated; Region: PRK07798 710421013683 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013684 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 710421013685 acyl-activating enzyme (AAE) consensus motif; other site 710421013686 acyl-activating enzyme (AAE) consensus motif; other site 710421013687 putative AMP binding site [chemical binding]; other site 710421013688 putative active site [active] 710421013689 putative CoA binding site [chemical binding]; other site 710421013690 enoyl-CoA hydratase; Provisional; Region: PRK07799 710421013691 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421013692 substrate binding site [chemical binding]; other site 710421013693 oxyanion hole (OAH) forming residues; other site 710421013694 trimer interface [polypeptide binding]; other site 710421013695 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421013696 Cytochrome P450; Region: p450; cl12078 710421013697 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 710421013698 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421013699 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 710421013700 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710421013701 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421013702 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710421013703 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421013704 lipid-transfer protein; Provisional; Region: PRK07937 710421013705 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421013706 active site 710421013707 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 710421013708 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421013709 active site 710421013710 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421013711 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421013712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421013713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421013715 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421013716 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 710421013717 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 710421013718 putative active site [active] 710421013719 putative metal binding site [ion binding]; other site 710421013720 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421013721 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 710421013722 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 710421013723 DXD motif; other site 710421013724 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 710421013725 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710421013726 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 710421013727 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 710421013728 short chain dehydrogenase; Provisional; Region: PRK07890 710421013729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013730 NAD(P) binding site [chemical binding]; other site 710421013731 active site 710421013732 Transcriptional regulator [Transcription]; Region: IclR; COG1414 710421013733 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 710421013734 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 710421013735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421013736 ATP binding site [chemical binding]; other site 710421013737 putative Mg++ binding site [ion binding]; other site 710421013738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421013739 nucleotide binding region [chemical binding]; other site 710421013740 ATP-binding site [chemical binding]; other site 710421013741 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 710421013742 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 710421013743 active site 710421013744 catalytic residues [active] 710421013745 metal binding site [ion binding]; metal-binding site 710421013746 DmpG-like communication domain; Region: DmpG_comm; pfam07836 710421013747 acetaldehyde dehydrogenase; Validated; Region: PRK08300 710421013748 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710421013749 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 710421013750 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 710421013751 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 710421013752 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 710421013753 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 710421013754 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 710421013755 dimer interaction site [polypeptide binding]; other site 710421013756 substrate-binding tunnel; other site 710421013757 active site 710421013758 catalytic site [active] 710421013759 substrate binding site [chemical binding]; other site 710421013760 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 710421013761 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 710421013762 putative active site [active] 710421013763 putative metal binding site [ion binding]; other site 710421013764 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 710421013765 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421013766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013767 NAD(P) binding site [chemical binding]; other site 710421013768 active site 710421013769 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421013770 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 710421013771 DXD motif; other site 710421013772 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 710421013773 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 710421013774 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 710421013775 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 710421013776 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 710421013777 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 710421013778 glutaminase active site [active] 710421013779 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710421013780 dimer interface [polypeptide binding]; other site 710421013781 active site 710421013782 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710421013783 dimer interface [polypeptide binding]; other site 710421013784 active site 710421013785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421013786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421013787 active site 710421013788 phosphorylation site [posttranslational modification] 710421013789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421013790 DNA binding residues [nucleotide binding] 710421013791 dimerization interface [polypeptide binding]; other site 710421013792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 710421013793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 710421013794 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 710421013795 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421013796 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 710421013797 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710421013798 acyl-activating enzyme (AAE) consensus motif; other site 710421013799 AMP binding site [chemical binding]; other site 710421013800 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 710421013801 active site 710421013802 catalytic residues [active] 710421013803 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 710421013804 putative active site [active] 710421013805 putative metal binding site [ion binding]; other site 710421013806 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421013807 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 710421013808 active site 710421013809 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710421013810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421013811 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421013812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421013813 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421013814 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 710421013815 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710421013816 Ligand binding site; other site 710421013817 Putative Catalytic site; other site 710421013818 DXD motif; other site 710421013819 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421013820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013821 NAD(P) binding site [chemical binding]; other site 710421013822 active site 710421013823 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 710421013824 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 710421013825 glutaminase active site [active] 710421013826 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 710421013827 dimer interface [polypeptide binding]; other site 710421013828 active site 710421013829 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 710421013830 dimer interface [polypeptide binding]; other site 710421013831 active site 710421013832 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421013833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 710421013834 active site 710421013835 intermolecular recognition site; other site 710421013836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421013837 DNA binding residues [nucleotide binding] 710421013838 dimerization interface [polypeptide binding]; other site 710421013839 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 710421013840 lipid-transfer protein; Provisional; Region: PRK07855 710421013841 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 710421013842 active site 710421013843 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 710421013844 putative active site [active] 710421013845 putative catalytic site [active] 710421013846 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710421013847 active site 710421013848 catalytic site [active] 710421013849 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 710421013850 DUF35 OB-fold domain; Region: DUF35; pfam01796 710421013851 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013852 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013853 active site 710421013854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013855 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421013856 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013857 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 710421013858 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421013859 Cytochrome P450; Region: p450; cl12078 710421013860 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 710421013861 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421013862 dimer interface [polypeptide binding]; other site 710421013863 active site 710421013864 Domain of unknown function (DUF385); Region: DUF385; pfam04075 710421013865 short chain dehydrogenase; Provisional; Region: PRK07791 710421013866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013867 NAD(P) binding site [chemical binding]; other site 710421013868 active site 710421013869 short chain dehydrogenase; Provisional; Region: PRK07856 710421013870 classical (c) SDRs; Region: SDR_c; cd05233 710421013871 NAD(P) binding site [chemical binding]; other site 710421013872 active site 710421013873 enoyl-CoA hydratase; Provisional; Region: PRK06495 710421013874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421013875 substrate binding site [chemical binding]; other site 710421013876 oxyanion hole (OAH) forming residues; other site 710421013877 trimer interface [polypeptide binding]; other site 710421013878 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 710421013879 Coenzyme A transferase; Region: CoA_trans; cl17247 710421013880 Nitronate monooxygenase; Region: NMO; pfam03060 710421013881 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 710421013882 FMN binding site [chemical binding]; other site 710421013883 substrate binding site [chemical binding]; other site 710421013884 putative catalytic residue [active] 710421013885 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 710421013886 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 710421013887 NAD binding site [chemical binding]; other site 710421013888 catalytic Zn binding site [ion binding]; other site 710421013889 substrate binding site [chemical binding]; other site 710421013890 structural Zn binding site [ion binding]; other site 710421013891 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 710421013892 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421013893 dimer interface [polypeptide binding]; other site 710421013894 active site 710421013895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421013896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013897 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 710421013898 short chain dehydrogenase; Provisional; Region: PRK07831 710421013899 classical (c) SDRs; Region: SDR_c; cd05233 710421013900 NAD(P) binding site [chemical binding]; other site 710421013901 active site 710421013902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013904 active site 710421013905 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 710421013906 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013907 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 710421013908 acyl-activating enzyme (AAE) consensus motif; other site 710421013909 putative AMP binding site [chemical binding]; other site 710421013910 putative active site [active] 710421013911 putative CoA binding site [chemical binding]; other site 710421013912 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013914 active site 710421013915 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421013916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013918 active site 710421013919 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421013920 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013921 active site 710421013922 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 710421013923 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 710421013924 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 710421013925 DNA binding residues [nucleotide binding] 710421013926 dimer interface [polypeptide binding]; other site 710421013927 putative metal binding site [ion binding]; other site 710421013928 aspartate aminotransferase; Provisional; Region: PRK05764 710421013929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421013930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421013931 homodimer interface [polypeptide binding]; other site 710421013932 catalytic residue [active] 710421013933 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 710421013934 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421013935 acyl-activating enzyme (AAE) consensus motif; other site 710421013936 AMP binding site [chemical binding]; other site 710421013937 active site 710421013938 CoA binding site [chemical binding]; other site 710421013939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421013940 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 710421013941 NAD(P) binding site [chemical binding]; other site 710421013942 active site 710421013943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421013944 metabolite-proton symporter; Region: 2A0106; TIGR00883 710421013945 putative substrate translocation pore; other site 710421013946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710421013947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421013948 LysR substrate binding domain; Region: LysR_substrate; pfam03466 710421013949 dimerization interface [polypeptide binding]; other site 710421013950 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 710421013951 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421013952 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 710421013953 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 710421013954 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 710421013955 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 710421013956 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 710421013957 active site 710421013958 Fe binding site [ion binding]; other site 710421013959 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 710421013960 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 710421013961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013962 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 710421013963 Flavin binding site [chemical binding]; other site 710421013964 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 710421013965 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 710421013966 FAD binding pocket [chemical binding]; other site 710421013967 FAD binding motif [chemical binding]; other site 710421013968 phosphate binding motif [ion binding]; other site 710421013969 beta-alpha-beta structure motif; other site 710421013970 NAD(p) ribose binding residues [chemical binding]; other site 710421013971 NAD binding pocket [chemical binding]; other site 710421013972 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 710421013973 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 710421013974 catalytic loop [active] 710421013975 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 710421013976 iron binding site [ion binding]; other site 710421013977 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 710421013978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013979 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013980 active site 710421013981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421013982 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421013983 active site 710421013984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421013985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421013986 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 710421013987 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 710421013988 Transcriptional regulators [Transcription]; Region: PurR; COG1609 710421013989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 710421013990 DNA binding site [nucleotide binding] 710421013991 domain linker motif; other site 710421013992 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 710421013993 putative dimerization interface [polypeptide binding]; other site 710421013994 putative ligand binding site [chemical binding]; other site 710421013995 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 710421013996 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 710421013997 intersubunit interface [polypeptide binding]; other site 710421013998 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 710421013999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421014000 Walker A/P-loop; other site 710421014001 ATP binding site [chemical binding]; other site 710421014002 Q-loop/lid; other site 710421014003 ABC transporter signature motif; other site 710421014004 Walker B; other site 710421014005 D-loop; other site 710421014006 H-loop/switch region; other site 710421014007 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 710421014008 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 710421014009 putative PBP binding regions; other site 710421014010 ABC-ATPase subunit interface; other site 710421014011 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 710421014012 putative active site [active] 710421014013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421014014 putative DNA binding site [nucleotide binding]; other site 710421014015 putative Zn2+ binding site [ion binding]; other site 710421014016 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710421014017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710421014018 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 710421014019 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 710421014020 transmembrane helices; other site 710421014021 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710421014022 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 710421014023 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710421014024 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 710421014025 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710421014026 active site 710421014027 HIGH motif; other site 710421014028 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710421014029 KMSKS motif; other site 710421014030 tRNA binding surface [nucleotide binding]; other site 710421014031 anticodon binding site; other site 710421014032 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 710421014033 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 710421014034 homotrimer interaction site [polypeptide binding]; other site 710421014035 zinc binding site [ion binding]; other site 710421014036 CDP-binding sites; other site 710421014037 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 710421014038 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 710421014039 DNA repair protein RadA; Provisional; Region: PRK11823 710421014040 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 710421014041 Walker A motif/ATP binding site; other site 710421014042 ATP binding site [chemical binding]; other site 710421014043 Walker B motif; other site 710421014044 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 710421014045 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 710421014046 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 710421014047 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 710421014048 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 710421014049 active site clefts [active] 710421014050 zinc binding site [ion binding]; other site 710421014051 dimer interface [polypeptide binding]; other site 710421014052 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 710421014053 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710421014054 minor groove reading motif; other site 710421014055 helix-hairpin-helix signature motif; other site 710421014056 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 710421014057 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 710421014058 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 710421014059 conserved cys residue [active] 710421014060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421014061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421014062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710421014063 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710421014064 catalytic site [active] 710421014065 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 710421014066 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 710421014067 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 710421014068 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421014069 catalytic core [active] 710421014070 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 710421014071 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 710421014072 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 710421014073 Clp amino terminal domain; Region: Clp_N; pfam02861 710421014074 Clp amino terminal domain; Region: Clp_N; pfam02861 710421014075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421014076 Walker A motif; other site 710421014077 ATP binding site [chemical binding]; other site 710421014078 Walker B motif; other site 710421014079 arginine finger; other site 710421014080 UvrB/uvrC motif; Region: UVR; pfam02151 710421014081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421014082 Walker A motif; other site 710421014083 ATP binding site [chemical binding]; other site 710421014084 Walker B motif; other site 710421014085 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710421014086 Lsr2; Region: Lsr2; pfam11774 710421014087 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 710421014088 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 710421014089 dimer interface [polypeptide binding]; other site 710421014090 putative anticodon binding site; other site 710421014091 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710421014092 motif 1; other site 710421014093 dimer interface [polypeptide binding]; other site 710421014094 active site 710421014095 motif 2; other site 710421014096 motif 3; other site 710421014097 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 710421014098 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 710421014099 active site 710421014100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 710421014101 dimer interface [polypeptide binding]; other site 710421014102 substrate binding site [chemical binding]; other site 710421014103 catalytic residue [active] 710421014104 pantothenate kinase; Reviewed; Region: PRK13318 710421014105 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 710421014106 tetramerization interface [polypeptide binding]; other site 710421014107 active site 710421014108 Pantoate-beta-alanine ligase; Region: PanC; cd00560 710421014109 pantoate--beta-alanine ligase; Region: panC; TIGR00018 710421014110 active site 710421014111 ATP-binding site [chemical binding]; other site 710421014112 pantoate-binding site; other site 710421014113 HXXH motif; other site 710421014114 Rossmann-like domain; Region: Rossmann-like; pfam10727 710421014115 Uncharacterized conserved protein [Function unknown]; Region: COG5495 710421014116 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 710421014117 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 710421014118 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 710421014119 catalytic center binding site [active] 710421014120 ATP binding site [chemical binding]; other site 710421014121 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 710421014122 homooctamer interface [polypeptide binding]; other site 710421014123 active site 710421014124 dihydropteroate synthase; Region: DHPS; TIGR01496 710421014125 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 710421014126 substrate binding pocket [chemical binding]; other site 710421014127 dimer interface [polypeptide binding]; other site 710421014128 inhibitor binding site; inhibition site 710421014129 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 710421014130 homodecamer interface [polypeptide binding]; other site 710421014131 GTP cyclohydrolase I; Provisional; Region: PLN03044 710421014132 active site 710421014133 putative catalytic site residues [active] 710421014134 zinc binding site [ion binding]; other site 710421014135 GTP-CH-I/GFRP interaction surface; other site 710421014136 FtsH Extracellular; Region: FtsH_ext; pfam06480 710421014137 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 710421014138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421014139 Walker A motif; other site 710421014140 ATP binding site [chemical binding]; other site 710421014141 Walker B motif; other site 710421014142 arginine finger; other site 710421014143 Peptidase family M41; Region: Peptidase_M41; pfam01434 710421014144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421014145 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710421014146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421014147 PE-PPE domain; Region: PE-PPE; pfam08237 710421014148 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 710421014149 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 710421014150 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 710421014151 molybdopterin cofactor binding site; other site 710421014152 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 710421014153 putative molybdopterin cofactor binding site; other site 710421014154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421014155 active site 710421014156 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 710421014157 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 710421014158 Ligand Binding Site [chemical binding]; other site 710421014159 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 710421014160 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 710421014161 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 710421014162 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 710421014163 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 710421014164 dimer interface [polypeptide binding]; other site 710421014165 substrate binding site [chemical binding]; other site 710421014166 metal binding sites [ion binding]; metal-binding site 710421014167 putative OHCU decarboxylase; Provisional; Region: PRK13798 710421014168 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421014169 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421014170 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 710421014171 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 710421014172 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 710421014173 acyl-activating enzyme (AAE) consensus motif; other site 710421014174 AMP binding site [chemical binding]; other site 710421014175 active site 710421014176 CoA binding site [chemical binding]; other site 710421014177 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 710421014178 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 710421014179 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710421014180 putative trimer interface [polypeptide binding]; other site 710421014181 putative CoA binding site [chemical binding]; other site 710421014182 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 710421014183 putative trimer interface [polypeptide binding]; other site 710421014184 putative CoA binding site [chemical binding]; other site 710421014185 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 710421014186 Zn binding site [ion binding]; other site 710421014187 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 710421014188 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 710421014189 Ligand binding site; other site 710421014190 Putative Catalytic site; other site 710421014191 DXD motif; other site 710421014192 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 710421014193 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 710421014194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421014195 NAD(P) binding site [chemical binding]; other site 710421014196 active site 710421014197 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 710421014198 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421014199 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421014200 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421014201 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421014202 active site 710421014203 DNA polymerase III subunit delta'; Validated; Region: PRK07940 710421014204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421014205 Walker A motif; other site 710421014206 ATP binding site [chemical binding]; other site 710421014207 Walker B motif; other site 710421014208 arginine finger; other site 710421014209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 710421014210 dimerization interface [polypeptide binding]; other site 710421014211 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421014212 cyclase homology domain; Region: CHD; cd07302 710421014213 nucleotidyl binding site; other site 710421014214 metal binding site [ion binding]; metal-binding site 710421014215 dimer interface [polypeptide binding]; other site 710421014216 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 710421014217 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 710421014218 active site 710421014219 interdomain interaction site; other site 710421014220 putative metal-binding site [ion binding]; other site 710421014221 nucleotide binding site [chemical binding]; other site 710421014222 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 710421014223 domain I; other site 710421014224 phosphate binding site [ion binding]; other site 710421014225 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 710421014226 domain II; other site 710421014227 domain III; other site 710421014228 nucleotide binding site [chemical binding]; other site 710421014229 DNA binding groove [nucleotide binding] 710421014230 catalytic site [active] 710421014231 domain IV; other site 710421014232 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710421014233 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710421014234 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 710421014235 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 710421014236 DNA-binding site [nucleotide binding]; DNA binding site 710421014237 RNA-binding motif; other site 710421014238 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 710421014239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421014240 ATP binding site [chemical binding]; other site 710421014241 putative Mg++ binding site [ion binding]; other site 710421014242 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 710421014243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421014244 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421014245 active site 710421014246 ATP binding site [chemical binding]; other site 710421014247 substrate binding site [chemical binding]; other site 710421014248 activation loop (A-loop); other site 710421014249 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 710421014250 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 710421014251 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 710421014252 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 710421014253 catalytic residues [active] 710421014254 catalytic nucleophile [active] 710421014255 Recombinase; Region: Recombinase; pfam07508 710421014256 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 710421014257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710421014258 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710421014259 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 710421014260 Walker A motif; other site 710421014261 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 710421014262 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 710421014263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421014264 motif II; other site 710421014265 acetyl-CoA synthetase; Provisional; Region: PRK00174 710421014266 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 710421014267 active site 710421014268 CoA binding site [chemical binding]; other site 710421014269 acyl-activating enzyme (AAE) consensus motif; other site 710421014270 AMP binding site [chemical binding]; other site 710421014271 acetate binding site [chemical binding]; other site 710421014272 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 710421014273 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421014274 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710421014275 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710421014276 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710421014277 putative active site [active] 710421014278 putative CoA binding site [chemical binding]; other site 710421014279 nudix motif; other site 710421014280 metal binding site [ion binding]; metal-binding site 710421014281 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 710421014282 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421014283 catalytic residues [active] 710421014284 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 710421014285 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710421014286 minor groove reading motif; other site 710421014287 helix-hairpin-helix signature motif; other site 710421014288 substrate binding pocket [chemical binding]; other site 710421014289 active site 710421014290 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 710421014291 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 710421014292 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 710421014293 ligand binding site [chemical binding]; other site 710421014294 flexible hinge region; other site 710421014295 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 710421014296 putative switch regulator; other site 710421014297 non-specific DNA interactions [nucleotide binding]; other site 710421014298 DNA binding site [nucleotide binding] 710421014299 sequence specific DNA binding site [nucleotide binding]; other site 710421014300 putative cAMP binding site [chemical binding]; other site 710421014301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421014302 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 710421014303 homotrimer interaction site [polypeptide binding]; other site 710421014304 putative active site [active] 710421014305 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 710421014306 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710421014307 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710421014308 P loop; other site 710421014309 Nucleotide binding site [chemical binding]; other site 710421014310 DTAP/Switch II; other site 710421014311 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 710421014312 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 710421014313 DTAP/Switch II; other site 710421014314 Switch I; other site 710421014315 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710421014316 Transcription factor WhiB; Region: Whib; pfam02467 710421014317 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 710421014318 Transglycosylase; Region: Transgly; pfam00912 710421014319 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 710421014320 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 710421014321 phosphodiesterase YaeI; Provisional; Region: PRK11340 710421014322 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 710421014323 putative active site [active] 710421014324 putative metal binding site [ion binding]; other site 710421014325 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 710421014326 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 710421014327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421014328 catalytic residue [active] 710421014329 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 710421014330 active site 710421014331 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421014332 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 710421014333 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 710421014334 MoxR-like ATPases [General function prediction only]; Region: COG0714 710421014335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421014336 Walker A motif; other site 710421014337 ATP binding site [chemical binding]; other site 710421014338 Walker B motif; other site 710421014339 arginine finger; other site 710421014340 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 710421014341 Protein of unknown function DUF58; Region: DUF58; pfam01882 710421014342 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 710421014343 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 710421014344 Predicted membrane protein/domain [Function unknown]; Region: COG1714 710421014345 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 710421014346 Cupin; Region: Cupin_6; pfam12852 710421014347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421014348 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 710421014349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 710421014350 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 710421014351 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 710421014352 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 710421014353 Predicted transcriptional regulators [Transcription]; Region: COG1695 710421014354 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710421014355 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710421014356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710421014357 active site 710421014358 catalytic tetrad [active] 710421014359 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 710421014360 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 710421014361 G1 box; other site 710421014362 putative GEF interaction site [polypeptide binding]; other site 710421014363 GTP/Mg2+ binding site [chemical binding]; other site 710421014364 Switch I region; other site 710421014365 G2 box; other site 710421014366 G3 box; other site 710421014367 Switch II region; other site 710421014368 G4 box; other site 710421014369 G5 box; other site 710421014370 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 710421014371 glycerol kinase; Provisional; Region: glpK; PRK00047 710421014372 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421014373 nucleotide binding site [chemical binding]; other site 710421014374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421014375 S-adenosylmethionine binding site [chemical binding]; other site 710421014376 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421014377 phosphopeptide binding site; other site 710421014378 cyclase homology domain; Region: CHD; cd07302 710421014379 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421014380 nucleotidyl binding site; other site 710421014381 metal binding site [ion binding]; metal-binding site 710421014382 dimer interface [polypeptide binding]; other site 710421014383 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421014384 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421014385 active site 710421014386 ATP binding site [chemical binding]; other site 710421014387 substrate binding site [chemical binding]; other site 710421014388 activation loop (A-loop); other site 710421014389 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 710421014390 cyclase homology domain; Region: CHD; cd07302 710421014391 nucleotidyl binding site; other site 710421014392 metal binding site [ion binding]; metal-binding site 710421014393 dimer interface [polypeptide binding]; other site 710421014394 Predicted ATPase [General function prediction only]; Region: COG3899 710421014395 AAA ATPase domain; Region: AAA_16; pfam13191 710421014396 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 710421014397 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 710421014398 DNA binding site [nucleotide binding] 710421014399 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 710421014400 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 710421014401 phosphopeptide binding site; other site 710421014402 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 710421014403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421014404 S-adenosylmethionine binding site [chemical binding]; other site 710421014405 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 710421014406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421014407 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710421014408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421014409 catalytic residue [active] 710421014410 Uncharacterized conserved protein [Function unknown]; Region: COG4301 710421014411 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 710421014412 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 710421014413 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 710421014414 putative active site [active] 710421014415 putative dimer interface [polypeptide binding]; other site 710421014416 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 710421014417 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 710421014418 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 710421014419 PknH-like extracellular domain; Region: PknH_C; pfam14032 710421014420 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 710421014421 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 710421014422 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 710421014423 tetramer interface [polypeptide binding]; other site 710421014424 heme binding pocket [chemical binding]; other site 710421014425 NADPH binding site [chemical binding]; other site 710421014426 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 710421014427 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 710421014428 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 710421014429 aspartate kinase; Reviewed; Region: PRK06635 710421014430 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 710421014431 putative nucleotide binding site [chemical binding]; other site 710421014432 putative catalytic residues [active] 710421014433 putative Mg ion binding site [ion binding]; other site 710421014434 putative aspartate binding site [chemical binding]; other site 710421014435 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 710421014436 putative allosteric regulatory site; other site 710421014437 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 710421014438 putative allosteric regulatory residue; other site 710421014439 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 710421014440 putative FMN binding site [chemical binding]; other site 710421014441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421014442 putative DNA binding site [nucleotide binding]; other site 710421014443 dimerization interface [polypeptide binding]; other site 710421014444 putative Zn2+ binding site [ion binding]; other site 710421014445 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 710421014446 putative hydrophobic ligand binding site [chemical binding]; other site 710421014447 CLM binding site; other site 710421014448 L1 loop; other site 710421014449 DNA binding site [nucleotide binding] 710421014450 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421014451 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421014452 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710421014453 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 710421014454 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 710421014455 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 710421014456 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 710421014457 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 710421014458 active site 710421014459 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 710421014460 domain_subunit interface; other site 710421014461 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710421014462 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 710421014463 active site 710421014464 FMN binding site [chemical binding]; other site 710421014465 substrate binding site [chemical binding]; other site 710421014466 3Fe-4S cluster binding site [ion binding]; other site 710421014467 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710421014468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421014469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 710421014470 non-specific DNA binding site [nucleotide binding]; other site 710421014471 salt bridge; other site 710421014472 sequence-specific DNA binding site [nucleotide binding]; other site 710421014473 Cupin domain; Region: Cupin_2; pfam07883 710421014474 2-isopropylmalate synthase; Validated; Region: PRK03739 710421014475 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 710421014476 active site 710421014477 catalytic residues [active] 710421014478 metal binding site [ion binding]; metal-binding site 710421014479 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 710421014480 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 710421014481 Short C-terminal domain; Region: SHOCT; pfam09851 710421014482 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 710421014483 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710421014484 active site 710421014485 catalytic site [active] 710421014486 substrate binding site [chemical binding]; other site 710421014487 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 710421014488 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 710421014489 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 710421014490 catalytic triad [active] 710421014491 Mitochondrial ribosomal protein subunit; Region: Mit_ribos_Mrp51; pfam11709 710421014492 recombination protein RecR; Reviewed; Region: recR; PRK00076 710421014493 RecR protein; Region: RecR; pfam02132 710421014494 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 710421014495 putative active site [active] 710421014496 putative metal-binding site [ion binding]; other site 710421014497 tetramer interface [polypeptide binding]; other site 710421014498 hypothetical protein; Validated; Region: PRK00153 710421014499 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710421014500 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710421014501 active site 710421014502 metal binding site [ion binding]; metal-binding site 710421014503 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 710421014504 hydrophobic ligand binding site; other site 710421014505 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710421014506 FAD binding domain; Region: FAD_binding_4; pfam01565 710421014507 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 710421014508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421014509 S-adenosylmethionine binding site [chemical binding]; other site 710421014510 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 710421014511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710421014512 Walker A motif; other site 710421014513 ATP binding site [chemical binding]; other site 710421014514 Walker B motif; other site 710421014515 arginine finger; other site 710421014516 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 710421014517 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 710421014518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421014519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421014520 catalytic residue [active] 710421014521 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710421014522 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421014523 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 710421014524 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 710421014525 EamA-like transporter family; Region: EamA; pfam00892 710421014526 EamA-like transporter family; Region: EamA; pfam00892 710421014527 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 710421014528 VCBS repeat; Region: VCBS_repeat; TIGR01965 710421014529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421014530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421014531 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 710421014532 nucleotide binding site [chemical binding]; other site 710421014533 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710421014534 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710421014535 active site 710421014536 DNA binding site [nucleotide binding] 710421014537 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710421014538 DNA binding site [nucleotide binding] 710421014539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421014540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421014541 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421014542 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710421014543 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 710421014544 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 710421014545 active site 710421014546 DNA binding site [nucleotide binding] 710421014547 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 710421014548 DNA binding site [nucleotide binding] 710421014549 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710421014550 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421014551 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421014552 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421014553 active site 710421014554 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 710421014555 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 710421014556 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cl12104 710421014557 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 710421014558 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 710421014559 alpha-beta subunit interface [polypeptide binding]; other site 710421014560 alpha-gamma subunit interface [polypeptide binding]; other site 710421014561 active site 710421014562 substrate and K+ binding site; other site 710421014563 K+ binding site [ion binding]; other site 710421014564 cobalamin binding site [chemical binding]; other site 710421014565 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 710421014566 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 710421014567 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 710421014568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421014569 inhibitor-cofactor binding pocket; inhibition site 710421014570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421014571 catalytic residue [active] 710421014572 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 710421014573 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 710421014574 putative catalytic cysteine [active] 710421014575 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 710421014576 putative hexamer interface [polypeptide binding]; other site 710421014577 putative hexagonal pore; other site 710421014578 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 710421014579 putative hexamer interface [polypeptide binding]; other site 710421014580 putative hexagonal pore; other site 710421014581 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 710421014582 Hexamer/Pentamer interface [polypeptide binding]; other site 710421014583 central pore; other site 710421014584 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 710421014585 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 710421014586 Hexamer interface [polypeptide binding]; other site 710421014587 Hexagonal pore residue; other site 710421014588 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 710421014589 Hexamer interface [polypeptide binding]; other site 710421014590 Hexagonal pore residue; other site 710421014591 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 710421014592 putative hexamer interface [polypeptide binding]; other site 710421014593 putative hexagonal pore; other site 710421014594 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710421014595 Phosphotransferase enzyme family; Region: APH; pfam01636 710421014596 active site 710421014597 ATP binding site [chemical binding]; other site 710421014598 substrate binding site [chemical binding]; other site 710421014599 short chain dehydrogenase; Provisional; Region: PRK12829 710421014600 classical (c) SDRs; Region: SDR_c; cd05233 710421014601 NAD(P) binding site [chemical binding]; other site 710421014602 active site 710421014603 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 710421014604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421014605 DNA-binding site [nucleotide binding]; DNA binding site 710421014606 UTRA domain; Region: UTRA; pfam07702 710421014607 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 710421014608 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 710421014609 active site 710421014610 HIGH motif; other site 710421014611 nucleotide binding site [chemical binding]; other site 710421014612 active site 710421014613 KMSKS motif; other site 710421014614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421014615 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421014616 substrate binding pocket [chemical binding]; other site 710421014617 membrane-bound complex binding site; other site 710421014618 hinge residues; other site 710421014619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421014620 dimer interface [polypeptide binding]; other site 710421014621 conserved gate region; other site 710421014622 putative PBP binding loops; other site 710421014623 ABC-ATPase subunit interface; other site 710421014624 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710421014625 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710421014626 Walker A/P-loop; other site 710421014627 ATP binding site [chemical binding]; other site 710421014628 Q-loop/lid; other site 710421014629 ABC transporter signature motif; other site 710421014630 Walker B; other site 710421014631 D-loop; other site 710421014632 H-loop/switch region; other site 710421014633 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 710421014634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421014635 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710421014636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421014637 NAD(P) binding site [chemical binding]; other site 710421014638 active site 710421014639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421014640 NAD(P) binding site [chemical binding]; other site 710421014641 active site 710421014642 MMPL family; Region: MMPL; pfam03176 710421014643 MMPL family; Region: MMPL; pfam03176 710421014644 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421014645 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 710421014646 dimer interface [polypeptide binding]; other site 710421014647 active site 710421014648 short chain dehydrogenase; Provisional; Region: PRK06197 710421014649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421014650 NAD(P) binding site [chemical binding]; other site 710421014651 active site 710421014652 Cytochrome P450; Region: p450; cl12078 710421014653 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421014654 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421014655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421014656 substrate binding site [chemical binding]; other site 710421014657 oxyanion hole (OAH) forming residues; other site 710421014658 trimer interface [polypeptide binding]; other site 710421014659 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 710421014660 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421014661 Cytochrome P450; Region: p450; cl12078 710421014662 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 710421014663 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 710421014664 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710421014665 haloalkane dehalogenase; Provisional; Region: PRK00870 710421014666 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 710421014667 Protein of unknown function (DUF732); Region: DUF732; pfam05305 710421014668 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 710421014669 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 710421014670 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 710421014671 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 710421014672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710421014673 putative active site [active] 710421014674 heme pocket [chemical binding]; other site 710421014675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 710421014676 putative active site [active] 710421014677 heme pocket [chemical binding]; other site 710421014678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 710421014679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 710421014680 metal binding site [ion binding]; metal-binding site 710421014681 active site 710421014682 I-site; other site 710421014683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421014684 Predicted membrane protein [Function unknown]; Region: COG1289 710421014685 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 710421014686 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 710421014687 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 710421014688 Walker A/P-loop; other site 710421014689 ATP binding site [chemical binding]; other site 710421014690 Q-loop/lid; other site 710421014691 ABC transporter signature motif; other site 710421014692 Walker B; other site 710421014693 D-loop; other site 710421014694 H-loop/switch region; other site 710421014695 TOBE domain; Region: TOBE_2; pfam08402 710421014696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710421014697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421014698 dimer interface [polypeptide binding]; other site 710421014699 conserved gate region; other site 710421014700 putative PBP binding loops; other site 710421014701 ABC-ATPase subunit interface; other site 710421014702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421014703 dimer interface [polypeptide binding]; other site 710421014704 putative PBP binding loops; other site 710421014705 ABC-ATPase subunit interface; other site 710421014706 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 710421014707 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710421014708 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 710421014709 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 710421014710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421014711 DNA binding residues [nucleotide binding] 710421014712 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 710421014713 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 710421014714 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 710421014715 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 710421014716 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 710421014717 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 710421014718 putative substrate binding site [chemical binding]; other site 710421014719 putative ATP binding site [chemical binding]; other site 710421014720 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 710421014721 nucleoside/Zn binding site; other site 710421014722 dimer interface [polypeptide binding]; other site 710421014723 catalytic motif [active] 710421014724 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 710421014725 prephenate dehydrogenase; Validated; Region: PRK06545 710421014726 prephenate dehydrogenase; Validated; Region: PRK08507 710421014727 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 710421014728 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710421014729 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 710421014730 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710421014731 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 710421014732 Walker A/P-loop; other site 710421014733 ATP binding site [chemical binding]; other site 710421014734 Q-loop/lid; other site 710421014735 ABC transporter signature motif; other site 710421014736 Walker B; other site 710421014737 D-loop; other site 710421014738 H-loop/switch region; other site 710421014739 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 710421014740 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 710421014741 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 710421014742 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 710421014743 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710421014744 putative active site [active] 710421014745 putative substrate binding site [chemical binding]; other site 710421014746 ATP binding site [chemical binding]; other site 710421014747 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421014748 catalytic core [active] 710421014749 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 710421014750 classical (c) SDRs; Region: SDR_c; cd05233 710421014751 NAD(P) binding site [chemical binding]; other site 710421014752 active site 710421014753 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 710421014754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 710421014755 YodA lipocalin-like domain; Region: YodA; cl01365 710421014756 Cupin domain; Region: Cupin_2; pfam07883 710421014757 Protein of unknown function (DUF419); Region: DUF419; pfam04237 710421014758 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 710421014759 active site 710421014760 metal binding site [ion binding]; metal-binding site 710421014761 homotetramer interface [polypeptide binding]; other site 710421014762 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 710421014763 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 710421014764 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 710421014765 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 710421014766 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710421014767 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710421014768 D-pathway; other site 710421014769 Putative ubiquinol binding site [chemical binding]; other site 710421014770 Low-spin heme (heme b) binding site [chemical binding]; other site 710421014771 Putative water exit pathway; other site 710421014772 Binuclear center (heme o3/CuB) [ion binding]; other site 710421014773 K-pathway; other site 710421014774 Putative proton exit pathway; other site 710421014775 Predicted membrane protein [Function unknown]; Region: COG3305 710421014776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421014777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421014778 DNA binding residues [nucleotide binding] 710421014779 dimerization interface [polypeptide binding]; other site 710421014780 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421014781 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421014782 active site 710421014783 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 710421014784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 710421014785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421014786 homodimer interface [polypeptide binding]; other site 710421014787 catalytic residue [active] 710421014788 GXWXG protein; Region: GXWXG; pfam14231 710421014789 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 710421014790 enoyl-CoA hydratase; Provisional; Region: PRK06142 710421014791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421014792 substrate binding site [chemical binding]; other site 710421014793 oxyanion hole (OAH) forming residues; other site 710421014794 trimer interface [polypeptide binding]; other site 710421014795 metabolite-proton symporter; Region: 2A0106; TIGR00883 710421014796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421014797 putative substrate translocation pore; other site 710421014798 MarR family; Region: MarR; pfam01047 710421014799 MarR family; Region: MarR_2; cl17246 710421014800 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 710421014801 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 710421014802 NAD(P) binding site [chemical binding]; other site 710421014803 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710421014804 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421014805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710421014806 catalytic residue [active] 710421014807 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 710421014808 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 710421014809 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 710421014810 Walker A/P-loop; other site 710421014811 ATP binding site [chemical binding]; other site 710421014812 Q-loop/lid; other site 710421014813 ABC transporter signature motif; other site 710421014814 Walker B; other site 710421014815 D-loop; other site 710421014816 H-loop/switch region; other site 710421014817 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710421014818 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421014819 active site 710421014820 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 710421014821 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 710421014822 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 710421014823 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 710421014824 Uncharacterized conserved protein [Function unknown]; Region: COG2128 710421014825 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 710421014826 Predicted membrane protein [Function unknown]; Region: COG2246 710421014827 GtrA-like protein; Region: GtrA; pfam04138 710421014828 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 710421014829 FAD binding domain; Region: FAD_binding_4; pfam01565 710421014830 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 710421014831 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 710421014832 classical (c) SDRs; Region: SDR_c; cd05233 710421014833 NAD(P) binding site [chemical binding]; other site 710421014834 active site 710421014835 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 710421014836 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 710421014837 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710421014838 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710421014839 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 710421014840 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421014841 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421014842 active site 710421014843 ATP binding site [chemical binding]; other site 710421014844 substrate binding site [chemical binding]; other site 710421014845 activation loop (A-loop); other site 710421014846 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 710421014847 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 710421014848 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 710421014849 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 710421014850 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421014851 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 710421014852 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 710421014853 active site 710421014854 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 710421014855 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 710421014856 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 710421014857 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 710421014858 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 710421014859 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 710421014860 acyl-activating enzyme (AAE) consensus motif; other site 710421014861 active site 710421014862 Cutinase; Region: Cutinase; pfam01083 710421014863 Putative esterase; Region: Esterase; pfam00756 710421014864 Predicted esterase [General function prediction only]; Region: COG0627 710421014865 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 710421014866 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 710421014867 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 710421014868 active site 710421014869 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 710421014870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 710421014871 active site 710421014872 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 710421014873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421014874 UDP-galactopyranose mutase; Region: GLF; pfam03275 710421014875 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 710421014876 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 710421014877 amidase catalytic site [active] 710421014878 Zn binding residues [ion binding]; other site 710421014879 substrate binding site [chemical binding]; other site 710421014880 LGFP repeat; Region: LGFP; pfam08310 710421014881 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710421014882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421014883 motif II; other site 710421014884 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710421014885 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710421014886 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421014887 putative acyl-acceptor binding pocket; other site 710421014888 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421014889 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710421014890 putative acyl-acceptor binding pocket; other site 710421014891 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 710421014892 active site 710421014893 ATP binding site [chemical binding]; other site 710421014894 Phosphotransferase enzyme family; Region: APH; pfam01636 710421014895 substrate binding site [chemical binding]; other site 710421014896 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 710421014897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 710421014898 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 710421014899 iron-sulfur cluster [ion binding]; other site 710421014900 [2Fe-2S] cluster binding site [ion binding]; other site 710421014901 seryl-tRNA synthetase; Provisional; Region: PRK05431 710421014902 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 710421014903 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 710421014904 dimer interface [polypeptide binding]; other site 710421014905 active site 710421014906 motif 1; other site 710421014907 motif 2; other site 710421014908 motif 3; other site 710421014909 Septum formation; Region: Septum_form; pfam13845 710421014910 Septum formation; Region: Septum_form; pfam13845 710421014911 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 710421014912 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 710421014913 catalytic core [active] 710421014914 prephenate dehydratase; Provisional; Region: PRK11898 710421014915 Prephenate dehydratase; Region: PDT; pfam00800 710421014916 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 710421014917 putative L-Phe binding site [chemical binding]; other site 710421014918 CAAX protease self-immunity; Region: Abi; pfam02517 710421014919 Transcriptional regulator [Transcription]; Region: LytR; COG1316 710421014920 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 710421014921 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 710421014922 putative active site [active] 710421014923 catalytic site [active] 710421014924 putative metal binding site [ion binding]; other site 710421014925 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 710421014926 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 710421014927 active site residue [active] 710421014928 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710421014929 Catalytic site [active] 710421014930 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 710421014931 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 710421014932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 710421014933 CopC domain; Region: CopC; pfam04234 710421014934 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 710421014935 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 710421014936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 710421014937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421014938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421014939 DNA polymerase IV; Validated; Region: PRK03858 710421014940 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710421014941 active site 710421014942 DNA binding site [nucleotide binding] 710421014943 hypothetical protein; Provisional; Region: PRK07945 710421014944 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 710421014945 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 710421014946 active site 710421014947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 710421014948 dimerization interface [polypeptide binding]; other site 710421014949 putative DNA binding site [nucleotide binding]; other site 710421014950 putative Zn2+ binding site [ion binding]; other site 710421014951 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 710421014952 Sulfate transporter family; Region: Sulfate_transp; pfam00916 710421014953 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 710421014954 TIGR03086 family protein; Region: TIGR03086 710421014955 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421014956 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421014957 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 710421014958 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 710421014959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710421014960 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 710421014961 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 710421014962 active site 710421014963 dimer interface [polypeptide binding]; other site 710421014964 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 710421014965 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710421014966 active site 710421014967 FMN binding site [chemical binding]; other site 710421014968 substrate binding site [chemical binding]; other site 710421014969 3Fe-4S cluster binding site [ion binding]; other site 710421014970 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 710421014971 domain interface; other site 710421014972 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 710421014973 CoenzymeA binding site [chemical binding]; other site 710421014974 subunit interaction site [polypeptide binding]; other site 710421014975 PHB binding site; other site 710421014976 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 710421014977 amphipathic channel; other site 710421014978 Asn-Pro-Ala signature motifs; other site 710421014979 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 710421014980 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710421014981 dimerization interface [polypeptide binding]; other site 710421014982 DPS ferroxidase diiron center [ion binding]; other site 710421014983 ion pore; other site 710421014984 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 710421014985 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 710421014986 minor groove reading motif; other site 710421014987 helix-hairpin-helix signature motif; other site 710421014988 active site 710421014989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 710421014990 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 710421014991 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 710421014992 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 710421014993 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 710421014994 Helix-turn-helix domain; Region: HTH_38; pfam13936 710421014995 Integrase core domain; Region: rve; pfam00665 710421014996 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 710421014997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421014998 NAD(P) binding site [chemical binding]; other site 710421014999 active site 710421015000 SnoaL-like domain; Region: SnoaL_2; pfam12680 710421015001 SelR domain; Region: SelR; pfam01641 710421015002 methionine sulfoxide reductase B; Provisional; Region: PRK00222 710421015003 methionine sulfoxide reductase A; Provisional; Region: PRK14054 710421015004 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 710421015005 Cytochrome P450; Region: p450; cl12078 710421015006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421015007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421015008 Methyltransferase domain; Region: Methyltransf_24; pfam13578 710421015009 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 710421015010 Protein of unknown function, DUF608; Region: DUF608; pfam04685 710421015011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421015012 S-adenosylmethionine binding site [chemical binding]; other site 710421015013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 710421015014 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 710421015015 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 710421015016 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421015017 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 710421015018 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421015019 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421015020 active site 710421015021 golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522 710421015022 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 710421015023 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 710421015024 Isochorismatase family; Region: Isochorismatase; pfam00857 710421015025 catalytic triad [active] 710421015026 metal binding site [ion binding]; metal-binding site 710421015027 conserved cis-peptide bond; other site 710421015028 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 710421015029 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 710421015030 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 710421015031 active site 710421015032 catalytic site [active] 710421015033 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 710421015034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421015035 Walker A/P-loop; other site 710421015036 ATP binding site [chemical binding]; other site 710421015037 Q-loop/lid; other site 710421015038 ABC transporter signature motif; other site 710421015039 Walker B; other site 710421015040 D-loop; other site 710421015041 H-loop/switch region; other site 710421015042 ABC-2 type transporter; Region: ABC2_membrane; cl17235 710421015043 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 710421015044 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 710421015045 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 710421015046 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 710421015047 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 710421015048 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 710421015049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710421015050 active site 710421015051 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710421015052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710421015053 Walker A/P-loop; other site 710421015054 ATP binding site [chemical binding]; other site 710421015055 Q-loop/lid; other site 710421015056 ABC transporter signature motif; other site 710421015057 Walker B; other site 710421015058 D-loop; other site 710421015059 H-loop/switch region; other site 710421015060 TOBE domain; Region: TOBE_2; pfam08402 710421015061 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710421015062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421015063 dimer interface [polypeptide binding]; other site 710421015064 conserved gate region; other site 710421015065 putative PBP binding loops; other site 710421015066 ABC-ATPase subunit interface; other site 710421015067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 710421015068 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 710421015069 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 710421015070 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 710421015071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421015072 metabolite-proton symporter; Region: 2A0106; TIGR00883 710421015073 putative substrate translocation pore; other site 710421015074 K+ potassium transporter; Region: K_trans; cl15781 710421015075 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710421015076 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 710421015077 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 710421015078 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 710421015079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421015080 motif II; other site 710421015081 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421015082 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421015083 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 710421015084 Rhomboid family; Region: Rhomboid; pfam01694 710421015085 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 710421015086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421015087 active site 710421015088 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 710421015089 Beta-lactamase; Region: Beta-lactamase; pfam00144 710421015090 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 710421015091 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 710421015092 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 710421015093 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421015094 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 710421015095 putative NAD(P) binding site [chemical binding]; other site 710421015096 catalytic Zn binding site [ion binding]; other site 710421015097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421015098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421015099 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 710421015100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710421015101 ATP binding site [chemical binding]; other site 710421015102 putative Mg++ binding site [ion binding]; other site 710421015103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710421015104 nucleotide binding region [chemical binding]; other site 710421015105 Helicase associated domain (HA2); Region: HA2; pfam04408 710421015106 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 710421015107 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 710421015108 Uncharacterized conserved protein [Function unknown]; Region: COG0397 710421015109 hypothetical protein; Validated; Region: PRK00029 710421015110 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421015111 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421015112 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 710421015113 hypothetical protein; Provisional; Region: PRK06062 710421015114 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 710421015115 inhibitor-cofactor binding pocket; inhibition site 710421015116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421015117 catalytic residue [active] 710421015118 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 710421015119 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 710421015120 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 710421015121 active site 710421015122 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421015123 classical (c) SDRs; Region: SDR_c; cd05233 710421015124 NAD(P) binding site [chemical binding]; other site 710421015125 active site 710421015126 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 710421015127 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 710421015128 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 710421015129 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 710421015130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 710421015131 MOSC domain; Region: MOSC; pfam03473 710421015132 Mechanosensitive ion channel; Region: MS_channel; pfam00924 710421015133 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 710421015134 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 710421015135 Ligand Binding Site [chemical binding]; other site 710421015136 short chain dehydrogenase; Provisional; Region: PRK06841 710421015137 classical (c) SDRs; Region: SDR_c; cd05233 710421015138 NAD(P) binding site [chemical binding]; other site 710421015139 active site 710421015140 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 710421015141 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 710421015142 DNA binding residues [nucleotide binding] 710421015143 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 710421015144 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 710421015145 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710421015146 nucleotide binding site [chemical binding]; other site 710421015147 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 710421015148 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421015149 inhibitor binding site; inhibition site 710421015150 catalytic Zn binding site [ion binding]; other site 710421015151 structural Zn binding site [ion binding]; other site 710421015152 NADP binding site [chemical binding]; other site 710421015153 tetramer interface [polypeptide binding]; other site 710421015154 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 710421015155 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 710421015156 Walker A/P-loop; other site 710421015157 ATP binding site [chemical binding]; other site 710421015158 Q-loop/lid; other site 710421015159 ABC transporter signature motif; other site 710421015160 Walker B; other site 710421015161 D-loop; other site 710421015162 H-loop/switch region; other site 710421015163 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 710421015164 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710421015165 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 710421015166 TM-ABC transporter signature motif; other site 710421015167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 710421015168 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 710421015169 putative ligand binding site [chemical binding]; other site 710421015170 Domain of unknown function (DUF222); Region: DUF222; pfam02720 710421015171 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 710421015172 active site 710421015173 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 710421015174 intersubunit interface [polypeptide binding]; other site 710421015175 active site 710421015176 Zn2+ binding site [ion binding]; other site 710421015177 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 710421015178 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 710421015179 NAD(P) binding site [chemical binding]; other site 710421015180 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 710421015181 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 710421015182 putative N- and C-terminal domain interface [polypeptide binding]; other site 710421015183 putative active site [active] 710421015184 MgATP binding site [chemical binding]; other site 710421015185 catalytic site [active] 710421015186 metal binding site [ion binding]; metal-binding site 710421015187 putative carbohydrate binding site [chemical binding]; other site 710421015188 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 710421015189 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 710421015190 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 710421015191 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 710421015192 putative active site [active] 710421015193 putative CoA binding site [chemical binding]; other site 710421015194 nudix motif; other site 710421015195 metal binding site [ion binding]; metal-binding site 710421015196 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 710421015197 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 710421015198 dimer interface [polypeptide binding]; other site 710421015199 active site 710421015200 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 710421015201 putative methyltransferase; Provisional; Region: PRK14967 710421015202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421015203 S-adenosylmethionine binding site [chemical binding]; other site 710421015204 Cutinase; Region: Cutinase; pfam01083 710421015205 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 710421015206 intracellular protease, PfpI family; Region: PfpI; TIGR01382 710421015207 proposed catalytic triad [active] 710421015208 conserved cys residue [active] 710421015209 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 710421015210 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710421015211 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 710421015212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710421015213 motif II; other site 710421015214 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710421015215 Biofilm formation and stress response factor; Region: BsmA; pfam10014 710421015216 ribonuclease Z; Reviewed; Region: PRK00055 710421015217 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 710421015218 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 710421015219 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 710421015220 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421015221 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 710421015222 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 710421015223 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 710421015224 putative active site [active] 710421015225 catalytic site [active] 710421015226 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 710421015227 putative active site [active] 710421015228 catalytic site [active] 710421015229 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 710421015230 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 710421015231 tetramer interface [polypeptide binding]; other site 710421015232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 710421015233 catalytic residue [active] 710421015234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421015235 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 710421015236 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 710421015237 [2Fe-2S] cluster binding site [ion binding]; other site 710421015238 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 710421015239 putative alpha subunit interface [polypeptide binding]; other site 710421015240 putative active site [active] 710421015241 putative substrate binding site [chemical binding]; other site 710421015242 Fe binding site [ion binding]; other site 710421015243 short chain dehydrogenase; Provisional; Region: PRK08278 710421015244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015245 NAD(P) binding site [chemical binding]; other site 710421015246 active site 710421015247 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 710421015248 Phosphotransferase enzyme family; Region: APH; pfam01636 710421015249 putative active site [active] 710421015250 putative substrate binding site [chemical binding]; other site 710421015251 ATP binding site [chemical binding]; other site 710421015252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421015253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421015254 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 710421015255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 710421015256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 710421015257 active site 710421015258 enoyl-CoA hydratase; Provisional; Region: PRK05864 710421015259 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421015260 substrate binding site [chemical binding]; other site 710421015261 oxyanion hole (OAH) forming residues; other site 710421015262 trimer interface [polypeptide binding]; other site 710421015263 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 710421015264 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 710421015265 dimer interface [polypeptide binding]; other site 710421015266 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 710421015267 active site 710421015268 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 710421015269 classical (c) SDRs; Region: SDR_c; cd05233 710421015270 NAD(P) binding site [chemical binding]; other site 710421015271 active site 710421015272 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 710421015273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421015274 AAA ATPase domain; Region: AAA_16; pfam13191 710421015275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 710421015276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 710421015277 DNA binding residues [nucleotide binding] 710421015278 dimerization interface [polypeptide binding]; other site 710421015279 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 710421015280 putative FMN binding site [chemical binding]; other site 710421015281 NADH(P)-binding; Region: NAD_binding_10; pfam13460 710421015282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015283 active site 710421015284 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 710421015285 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 710421015286 B12 binding domain; Region: B12-binding_2; pfam02607 710421015287 B12 binding domain; Region: B12-binding; pfam02310 710421015288 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421015289 anti sigma factor interaction site; other site 710421015290 regulatory phosphorylation site [posttranslational modification]; other site 710421015291 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 710421015292 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 710421015293 putative DNA binding site [nucleotide binding]; other site 710421015294 catalytic residue [active] 710421015295 putative H2TH interface [polypeptide binding]; other site 710421015296 putative catalytic residues [active] 710421015297 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710421015298 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 710421015299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421015300 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 710421015301 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 710421015302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 710421015303 short chain dehydrogenase; Provisional; Region: PRK06500 710421015304 classical (c) SDRs; Region: SDR_c; cd05233 710421015305 NAD(P) binding site [chemical binding]; other site 710421015306 active site 710421015307 Transcriptional regulators [Transcription]; Region: MarR; COG1846 710421015308 MarR family; Region: MarR_2; pfam12802 710421015309 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 710421015310 active site 710421015311 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 710421015312 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 710421015313 active site 710421015314 NAD binding site [chemical binding]; other site 710421015315 metal binding site [ion binding]; metal-binding site 710421015316 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 710421015317 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 710421015318 G1 box; other site 710421015319 GTP/Mg2+ binding site [chemical binding]; other site 710421015320 G2 box; other site 710421015321 Switch I region; other site 710421015322 G3 box; other site 710421015323 Switch II region; other site 710421015324 G4 box; other site 710421015325 G5 box; other site 710421015326 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 710421015327 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 710421015328 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 710421015329 selenocysteine synthase; Provisional; Region: PRK04311 710421015330 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 710421015331 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 710421015332 dimerization interface [polypeptide binding]; other site 710421015333 putative ATP binding site [chemical binding]; other site 710421015334 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 710421015335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421015336 putative substrate translocation pore; other site 710421015337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421015338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421015339 putative substrate translocation pore; other site 710421015340 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 710421015341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 710421015342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 710421015343 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 710421015344 putative dimerization interface [polypeptide binding]; other site 710421015345 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 710421015346 hydrophobic ligand binding site; other site 710421015347 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710421015348 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 710421015349 putative acyl-acceptor binding pocket; other site 710421015350 Copper resistance protein D; Region: CopD; pfam05425 710421015351 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710421015352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710421015353 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 710421015354 YCII-related domain; Region: YCII; cl00999 710421015355 hypothetical protein; Provisional; Region: PRK07236 710421015356 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 710421015357 Domain of unknown function (DUF427); Region: DUF427; pfam04248 710421015358 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 710421015359 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421015360 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 710421015361 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 710421015362 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 710421015363 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710421015364 Amidase; Region: Amidase; cl11426 710421015365 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421015366 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421015367 substrate binding site [chemical binding]; other site 710421015368 oxyanion hole (OAH) forming residues; other site 710421015369 trimer interface [polypeptide binding]; other site 710421015370 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 710421015371 putative FMN binding site [chemical binding]; other site 710421015372 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 710421015373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015374 NAD(P) binding site [chemical binding]; other site 710421015375 active site 710421015376 Predicted permease; Region: DUF318; cl17795 710421015377 Predicted permease; Region: DUF318; cl17795 710421015378 Uncharacterized conserved protein [Function unknown]; Region: COG2966 710421015379 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 710421015380 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 710421015381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710421015382 metabolite-proton symporter; Region: 2A0106; TIGR00883 710421015383 putative substrate translocation pore; other site 710421015384 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 710421015385 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 710421015386 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 710421015387 anti sigma factor interaction site; other site 710421015388 regulatory phosphorylation site [posttranslational modification]; other site 710421015389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 710421015390 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 710421015391 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 710421015392 FAD binding site [chemical binding]; other site 710421015393 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 710421015394 dimanganese center [ion binding]; other site 710421015395 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 710421015396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015397 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 710421015398 active site 710421015399 Peptidase family M48; Region: Peptidase_M48; cl12018 710421015400 Penicillinase repressor; Region: Pencillinase_R; cl17580 710421015401 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 710421015402 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710421015403 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 710421015404 phosphate binding site [ion binding]; other site 710421015405 Hemerythrin-like domain; Region: Hr-like; cd12108 710421015406 Fe binding site [ion binding]; other site 710421015407 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 710421015408 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 710421015409 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 710421015410 active site 710421015411 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 710421015412 catalytic triad [active] 710421015413 dimer interface [polypeptide binding]; other site 710421015414 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 710421015415 active site 710421015416 catalytic site [active] 710421015417 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 710421015418 active site 710421015419 catalytic site [active] 710421015420 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 710421015421 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 710421015422 TIGR03086 family protein; Region: TIGR03086 710421015423 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 710421015424 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 710421015425 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 710421015426 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 710421015427 MarR family; Region: MarR; pfam01047 710421015428 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 710421015429 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 710421015430 short chain dehydrogenase; Provisional; Region: PRK07109 710421015431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015432 NAD(P) binding site [chemical binding]; other site 710421015433 active site 710421015434 thiamine pyrophosphate protein; Provisional; Region: PRK08273 710421015435 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 710421015436 PYR/PP interface [polypeptide binding]; other site 710421015437 dimer interface [polypeptide binding]; other site 710421015438 tetramer interface [polypeptide binding]; other site 710421015439 TPP binding site [chemical binding]; other site 710421015440 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 710421015441 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 710421015442 TPP-binding site [chemical binding]; other site 710421015443 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 710421015444 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 710421015445 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 710421015446 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 710421015447 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 710421015448 metal binding site [ion binding]; metal-binding site 710421015449 substrate binding pocket [chemical binding]; other site 710421015450 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 710421015451 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 710421015452 active site 710421015453 FMN binding site [chemical binding]; other site 710421015454 substrate binding site [chemical binding]; other site 710421015455 3Fe-4S cluster binding site [ion binding]; other site 710421015456 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 710421015457 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 710421015458 dimer interface [polypeptide binding]; other site 710421015459 acyl-activating enzyme (AAE) consensus motif; other site 710421015460 putative active site [active] 710421015461 AMP binding site [chemical binding]; other site 710421015462 putative CoA binding site [chemical binding]; other site 710421015463 Protein of unknown function, DUF488; Region: DUF488; cl01246 710421015464 Domain of unknown function (DUF309); Region: DUF309; pfam03745 710421015465 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 710421015466 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710421015467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015468 NAD(P) binding site [chemical binding]; other site 710421015469 active site 710421015470 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 710421015471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 710421015472 substrate binding site [chemical binding]; other site 710421015473 oxyanion hole (OAH) forming residues; other site 710421015474 trimer interface [polypeptide binding]; other site 710421015475 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 710421015476 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 710421015477 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 710421015478 active site 710421015479 catalytic residues [active] 710421015480 Methyltransferase domain; Region: Methyltransf_31; pfam13847 710421015481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421015482 S-adenosylmethionine binding site [chemical binding]; other site 710421015483 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 710421015484 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 710421015485 MOSC domain; Region: MOSC; pfam03473 710421015486 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 710421015487 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 710421015488 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710421015489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421015490 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 710421015491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 710421015492 RibD C-terminal domain; Region: RibD_C; cl17279 710421015493 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710421015494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710421015495 RNA binding surface [nucleotide binding]; other site 710421015496 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 710421015497 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 710421015498 putative NAD(P) binding site [chemical binding]; other site 710421015499 RibD C-terminal domain; Region: RibD_C; cl17279 710421015500 O-methyltransferase; Region: Methyltransf_2; pfam00891 710421015501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 710421015502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 710421015503 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 710421015504 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 710421015505 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710421015506 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710421015507 active site 710421015508 ATP binding site [chemical binding]; other site 710421015509 substrate binding site [chemical binding]; other site 710421015510 activation loop (A-loop); other site 710421015511 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421015512 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421015513 substrate binding pocket [chemical binding]; other site 710421015514 membrane-bound complex binding site; other site 710421015515 hinge residues; other site 710421015516 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 710421015517 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710421015518 Walker A motif; other site 710421015519 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 710421015520 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710421015521 Walker A motif; other site 710421015522 ATP binding site [chemical binding]; other site 710421015523 Walker B motif; other site 710421015524 DNA binding loops [nucleotide binding] 710421015525 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 710421015526 protein-splicing catalytic site; other site 710421015527 thioester formation/cholesterol transfer; other site 710421015528 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 710421015529 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 710421015530 protein-splicing catalytic site; other site 710421015531 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710421015532 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 710421015533 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 710421015534 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 710421015535 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 710421015536 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 710421015537 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710421015538 dimer interface [polypeptide binding]; other site 710421015539 ssDNA binding site [nucleotide binding]; other site 710421015540 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710421015541 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 710421015542 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 710421015543 Predicted integral membrane protein [Function unknown]; Region: COG5650 710421015544 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 710421015545 Transglycosylase; Region: Transgly; pfam00912 710421015546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 710421015547 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 710421015548 Predicted transcriptional regulators [Transcription]; Region: COG1695 710421015549 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 710421015550 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 710421015551 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 710421015552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710421015553 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 710421015554 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 710421015555 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 710421015556 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 710421015557 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 710421015558 classical (c) SDRs; Region: SDR_c; cd05233 710421015559 NAD(P) binding site [chemical binding]; other site 710421015560 active site 710421015561 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 710421015562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015563 NAD(P) binding site [chemical binding]; other site 710421015564 active site 710421015565 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 710421015566 agmatinase; Region: agmatinase; TIGR01230 710421015567 oligomer interface [polypeptide binding]; other site 710421015568 putative active site [active] 710421015569 Mn binding site [ion binding]; other site 710421015570 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 710421015571 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 710421015572 active site 710421015573 catalytic site [active] 710421015574 Zn binding site [ion binding]; other site 710421015575 tetramer interface [polypeptide binding]; other site 710421015576 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 710421015577 active site 710421015578 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 710421015579 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 710421015580 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 710421015581 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 710421015582 Transcriptional regulators [Transcription]; Region: GntR; COG1802 710421015583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710421015584 DNA-binding site [nucleotide binding]; DNA binding site 710421015585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 710421015586 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 710421015587 substrate binding pocket [chemical binding]; other site 710421015588 membrane-bound complex binding site; other site 710421015589 hinge residues; other site 710421015590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710421015591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 710421015592 dimer interface [polypeptide binding]; other site 710421015593 conserved gate region; other site 710421015594 putative PBP binding loops; other site 710421015595 ABC-ATPase subunit interface; other site 710421015596 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 710421015597 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 710421015598 Walker A/P-loop; other site 710421015599 ATP binding site [chemical binding]; other site 710421015600 Q-loop/lid; other site 710421015601 ABC transporter signature motif; other site 710421015602 Walker B; other site 710421015603 D-loop; other site 710421015604 H-loop/switch region; other site 710421015605 MarR family; Region: MarR; pfam01047 710421015606 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 710421015607 short chain dehydrogenase; Provisional; Region: PRK08219 710421015608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 710421015609 NAD(P) binding site [chemical binding]; other site 710421015610 active site 710421015611 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 710421015612 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 710421015613 D-pathway; other site 710421015614 Putative ubiquinol binding site [chemical binding]; other site 710421015615 Low-spin heme (heme b) binding site [chemical binding]; other site 710421015616 Putative water exit pathway; other site 710421015617 Binuclear center (heme o3/CuB) [ion binding]; other site 710421015618 K-pathway; other site 710421015619 Putative proton exit pathway; other site 710421015620 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 710421015621 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 710421015622 HIGH motif; other site 710421015623 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710421015624 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710421015625 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710421015626 active site 710421015627 KMSKS motif; other site 710421015628 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 710421015629 tRNA binding surface [nucleotide binding]; other site 710421015630 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 710421015631 hypothetical protein; Validated; Region: PRK00228 710421015632 H+ Antiporter protein; Region: 2A0121; TIGR00900 710421015633 TIGR03084 family protein; Region: TIGR03084 710421015634 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 710421015635 Wyosine base formation; Region: Wyosine_form; pfam08608 710421015636 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 710421015637 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 710421015638 active site 710421015639 NTP binding site [chemical binding]; other site 710421015640 metal binding triad [ion binding]; metal-binding site 710421015641 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 710421015642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710421015643 Zn2+ binding site [ion binding]; other site 710421015644 Mg2+ binding site [ion binding]; other site 710421015645 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 710421015646 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 710421015647 active site 710421015648 Ap6A binding site [chemical binding]; other site 710421015649 nudix motif; other site 710421015650 metal binding site [ion binding]; metal-binding site 710421015651 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 710421015652 MviN-like protein; Region: MVIN; pfam03023 710421015653 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 710421015654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710421015655 DNA binding residues [nucleotide binding] 710421015656 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710421015657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710421015658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710421015659 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710421015660 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710421015661 catalytic residues [active] 710421015662 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 710421015663 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710421015664 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 710421015665 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 710421015666 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 710421015667 active site 710421015668 metal binding site [ion binding]; metal-binding site 710421015669 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 710421015670 ParB-like nuclease domain; Region: ParBc; pfam02195 710421015671 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710421015672 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421015673 P-loop; other site 710421015674 Magnesium ion binding site [ion binding]; other site 710421015675 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 710421015676 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710421015677 Magnesium ion binding site [ion binding]; other site 710421015678 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 710421015679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710421015680 S-adenosylmethionine binding site [chemical binding]; other site 710421015681 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 710421015682 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 710421015683 G-X-X-G motif; other site 710421015684 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 710421015685 RxxxH motif; other site 710421015686 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 710421015687 ribonuclease P; Reviewed; Region: rnpA; PRK00588 710421015688 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399