-- dump date   	20140619_152214
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
278137000001	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
278137000002	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137000003	active site
278137000004	DNA binding site [nucleotide binding]
278137000005	Int/Topo IB signature motif; other site
278137000006	Helix-turn-helix domain; Region: HTH_17; cl17695
278137000007	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
278137000008	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137000009	Magnesium ion binding site [ion binding]; other site
278137000010	Transcription factor WhiB; Region: Whib; pfam02467
278137000011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137000012	sequence-specific DNA binding site [nucleotide binding]; other site
278137000013	salt bridge; other site
278137000014	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137000015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137000016	S-adenosylmethionine binding site [chemical binding]; other site
278137000017	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
278137000018	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
278137000019	Thioredoxin; Region: Thioredoxin_4; pfam13462
278137000020	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137000021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137000022	S-adenosylmethionine binding site [chemical binding]; other site
278137000023	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137000024	cyclase homology domain; Region: CHD; cd07302
278137000025	nucleotidyl binding site; other site
278137000026	metal binding site [ion binding]; metal-binding site
278137000027	dimer interface [polypeptide binding]; other site
278137000028	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
278137000029	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
278137000030	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137000031	dimerization interface [polypeptide binding]; other site
278137000032	putative DNA binding site [nucleotide binding]; other site
278137000033	putative Zn2+ binding site [ion binding]; other site
278137000034	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
278137000035	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137000036	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137000037	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
278137000038	Low molecular weight phosphatase family; Region: LMWPc; cl00105
278137000039	active site
278137000040	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
278137000041	Low molecular weight phosphatase family; Region: LMWPc; cd00115
278137000042	active site
278137000043	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
278137000044	arsenical-resistance protein; Region: acr3; TIGR00832
278137000045	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137000046	dimerization interface [polypeptide binding]; other site
278137000047	putative DNA binding site [nucleotide binding]; other site
278137000048	putative Zn2+ binding site [ion binding]; other site
278137000049	DinB superfamily; Region: DinB_2; pfam12867
278137000050	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
278137000051	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137000052	putative metal binding site [ion binding]; other site
278137000053	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137000054	dimerization interface [polypeptide binding]; other site
278137000055	putative DNA binding site [nucleotide binding]; other site
278137000056	putative Zn2+ binding site [ion binding]; other site
278137000057	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137000058	active site
278137000059	catalytic residues [active]
278137000060	DNA binding site [nucleotide binding]
278137000061	Int/Topo IB signature motif; other site
278137000062	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
278137000063	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137000064	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137000065	active site
278137000066	catalytic residues [active]
278137000067	DNA binding site [nucleotide binding]
278137000068	Int/Topo IB signature motif; other site
278137000069	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
278137000070	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137000071	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
278137000072	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137000073	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137000074	Penicillinase repressor; Region: Pencillinase_R; cl17580
278137000075	Peptidase family M48; Region: Peptidase_M48; cl12018
278137000076	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137000077	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137000078	DNA binding site [nucleotide binding]
278137000079	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137000080	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137000081	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137000082	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
278137000083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137000084	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137000085	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
278137000086	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
278137000087	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
278137000088	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
278137000089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137000090	Mg2+ binding site [ion binding]; other site
278137000091	G-X-G motif; other site
278137000092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
278137000093	Integrase core domain; Region: rve_3; pfam13683
278137000094	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137000095	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137000096	active site
278137000097	catalytic residues [active]
278137000098	DNA binding site [nucleotide binding]
278137000099	Int/Topo IB signature motif; other site
278137000100	Transposase domain (DUF772); Region: DUF772; pfam05598
278137000101	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137000102	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
278137000103	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
278137000104	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137000105	active site
278137000106	catalytic residues [active]
278137000107	DNA binding site [nucleotide binding]
278137000108	Int/Topo IB signature motif; other site
278137000109	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
278137000110	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137000111	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
278137000112	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137000113	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137000114	active site
278137000115	DNA binding site [nucleotide binding]
278137000116	Int/Topo IB signature motif; other site
278137000117	Peptidase family M48; Region: Peptidase_M48; cl12018
278137000118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
278137000119	Integrase core domain; Region: rve; pfam00665
278137000120	Predicted transcriptional regulator [Transcription]; Region: COG3388
278137000121	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
278137000122	AAA domain; Region: AAA_22; pfam13401
278137000123	ATP-binding site [chemical binding]; other site
278137000124	Helix-turn-helix domain; Region: HTH_28; pfam13518
278137000125	Winged helix-turn helix; Region: HTH_29; pfam13551
278137000126	Homeodomain-like domain; Region: HTH_32; pfam13565
278137000127	Integrase core domain; Region: rve; pfam00665
278137000128	Integrase core domain; Region: rve_3; pfam13683
278137000129	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
278137000130	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137000131	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137000132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137000133	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137000134	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137000135	cyclase homology domain; Region: CHD; cd07302
278137000136	metal binding site [ion binding]; metal-binding site
278137000137	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137000138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137000139	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
278137000140	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137000141	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137000142	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137000143	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137000144	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137000145	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137000146	Domain of unknown function (DUF305); Region: DUF305; pfam03713
278137000147	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
278137000148	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137000149	dimer interface [polypeptide binding]; other site
278137000150	phosphorylation site [posttranslational modification]
278137000151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137000152	ATP binding site [chemical binding]; other site
278137000153	Mg2+ binding site [ion binding]; other site
278137000154	G-X-G motif; other site
278137000155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137000156	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
278137000157	active site
278137000158	phosphorylation site [posttranslational modification]
278137000159	intermolecular recognition site; other site
278137000160	dimerization interface [polypeptide binding]; other site
278137000161	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137000162	DNA binding site [nucleotide binding]
278137000163	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
278137000164	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
278137000165	Multicopper oxidase; Region: Cu-oxidase; pfam00394
278137000166	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
278137000167	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137000168	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137000169	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
278137000170	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
278137000171	catalytic residues [active]
278137000172	Penicillinase repressor; Region: Pencillinase_R; pfam03965
278137000173	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137000174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137000175	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137000176	Penicillinase repressor; Region: Pencillinase_R; pfam03965
278137000177	Peptidase family M48; Region: Peptidase_M48; cl12018
278137000178	Putative esterase; Region: Esterase; pfam00756
278137000179	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
278137000180	Peptidase family M23; Region: Peptidase_M23; pfam01551
278137000181	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
278137000182	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
278137000183	putative active site [active]
278137000184	catalytic triad [active]
278137000185	putative dimer interface [polypeptide binding]; other site
278137000186	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137000187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137000188	active site
278137000189	phosphorylation site [posttranslational modification]
278137000190	intermolecular recognition site; other site
278137000191	dimerization interface [polypeptide binding]; other site
278137000192	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137000193	DNA binding site [nucleotide binding]
278137000194	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
278137000195	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
278137000196	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
278137000197	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
278137000198	NodB motif; other site
278137000199	active site
278137000200	catalytic site [active]
278137000201	metal binding site [ion binding]; metal-binding site
278137000202	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
278137000203	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
278137000204	dimer interface [polypeptide binding]; other site
278137000205	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137000206	catalytic residue [active]
278137000207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137000208	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
278137000209	active site residue [active]
278137000210	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
278137000211	dimerization interface [polypeptide binding]; other site
278137000212	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
278137000213	putative homodimer interface [polypeptide binding]; other site
278137000214	putative homotetramer interface [polypeptide binding]; other site
278137000215	putative allosteric switch controlling residues; other site
278137000216	putative metal binding site [ion binding]; other site
278137000217	putative homodimer-homodimer interface [polypeptide binding]; other site
278137000218	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137000219	Domain of unknown function (DUF305); Region: DUF305; pfam03713
278137000220	Domain of unknown function (DUF305); Region: DUF305; pfam03713
278137000221	Predicted membrane protein [Function unknown]; Region: COG3462
278137000222	Short C-terminal domain; Region: SHOCT; pfam09851
278137000223	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
278137000224	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
278137000225	active site residue [active]
278137000226	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
278137000227	active site residue [active]
278137000228	PAP2 superfamily; Region: PAP2; pfam01569
278137000229	active site
278137000230	serine/threonine protein kinase; Provisional; Region: PRK14879
278137000231	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
278137000232	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
278137000233	metal-binding site [ion binding]
278137000234	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
278137000235	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137000236	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137000237	putative phosphoketolase; Provisional; Region: PRK05261
278137000238	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
278137000239	TPP-binding site; other site
278137000240	XFP C-terminal domain; Region: XFP_C; pfam09363
278137000241	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
278137000242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137000243	S-adenosylmethionine binding site [chemical binding]; other site
278137000244	Predicted amidohydrolase [General function prediction only]; Region: COG0388
278137000245	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
278137000246	active site
278137000247	catalytic triad [active]
278137000248	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
278137000249	putative active site [active]
278137000250	putative CoA binding site [chemical binding]; other site
278137000251	nudix motif; other site
278137000252	metal binding site [ion binding]; metal-binding site
278137000253	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137000254	Predicted membrane protein [Function unknown]; Region: COG3462
278137000255	Short C-terminal domain; Region: SHOCT; pfam09851
278137000256	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
278137000257	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
278137000258	Multicopper oxidase; Region: Cu-oxidase; pfam00394
278137000259	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
278137000260	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
278137000261	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
278137000262	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
278137000263	Methyltransferase domain; Region: Methyltransf_11; pfam08241
278137000264	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137000265	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
278137000266	active site residue [active]
278137000267	TrwC relaxase; Region: TrwC; pfam08751
278137000268	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
278137000269	AAA domain; Region: AAA_30; pfam13604
278137000270	Family description; Region: UvrD_C_2; pfam13538
278137000271	putative transposase OrfB; Reviewed; Region: PHA02517
278137000272	HTH-like domain; Region: HTH_21; pfam13276
278137000273	Integrase core domain; Region: rve; pfam00665
278137000274	Integrase core domain; Region: rve_3; pfam13683
278137000275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137000276	Transposase; Region: HTH_Tnp_1; cl17663
278137000277	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137000278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137000279	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137000280	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
278137000281	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137000282	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137000283	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137000284	YodL-like; Region: YodL; pfam14191
278137000285	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137000286	non-specific DNA binding site [nucleotide binding]; other site
278137000287	salt bridge; other site
278137000288	sequence-specific DNA binding site [nucleotide binding]; other site
278137000289	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137000290	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137000291	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137000292	replicative DNA helicase; Validated; Region: PRK07773
278137000293	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
278137000294	catalytic residues [active]
278137000295	ParB-like nuclease domain; Region: ParB; smart00470
278137000296	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
278137000297	DNA-binding interface [nucleotide binding]; DNA binding site
278137000298	Domain of unknown function (DUF932); Region: DUF932; pfam06067
278137000299	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
278137000300	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
278137000301	active site
278137000302	DNA binding site [nucleotide binding]
278137000303	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
278137000304	DNA binding site [nucleotide binding]
278137000305	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137000306	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137000307	active site
278137000308	ATP binding site [chemical binding]; other site
278137000309	substrate binding site [chemical binding]; other site
278137000310	activation loop (A-loop); other site
278137000311	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
278137000312	putative active site [active]
278137000313	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137000314	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137000315	non-specific DNA binding site [nucleotide binding]; other site
278137000316	salt bridge; other site
278137000317	sequence-specific DNA binding site [nucleotide binding]; other site
278137000318	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
278137000319	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
278137000320	Penicillinase repressor; Region: Pencillinase_R; pfam03965
278137000321	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137000322	cyclase homology domain; Region: CHD; cd07302
278137000323	nucleotidyl binding site; other site
278137000324	metal binding site [ion binding]; metal-binding site
278137000325	dimer interface [polypeptide binding]; other site
278137000326	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
278137000327	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137000328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137000329	S-adenosylmethionine binding site [chemical binding]; other site
278137000330	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
278137000331	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
278137000332	putative homotetramer interface [polypeptide binding]; other site
278137000333	putative homodimer interface [polypeptide binding]; other site
278137000334	putative allosteric switch controlling residues; other site
278137000335	putative metal binding site [ion binding]; other site
278137000336	putative homodimer-homodimer interface [polypeptide binding]; other site
278137000337	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
278137000338	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
278137000339	Rhodanese-like domain; Region: Rhodanese; pfam00581
278137000340	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
278137000341	active site residue [active]
278137000342	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137000343	dimerization interface [polypeptide binding]; other site
278137000344	putative DNA binding site [nucleotide binding]; other site
278137000345	putative Zn2+ binding site [ion binding]; other site
278137000346	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
278137000347	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137000348	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137000349	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
278137000350	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
278137000351	Cadmium resistance transporter; Region: Cad; pfam03596
278137000352	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
278137000353	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
278137000354	catalytic residues [active]
278137000355	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
278137000356	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
278137000357	dimer interface [polypeptide binding]; other site
278137000358	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137000359	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137000360	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
278137000361	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
278137000362	dimer interface [polypeptide binding]; other site
278137000363	decamer (pentamer of dimers) interface [polypeptide binding]; other site
278137000364	catalytic triad [active]
278137000365	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
278137000366	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
278137000367	TrwC relaxase; Region: TrwC; pfam08751
278137000368	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
278137000369	AAA domain; Region: AAA_30; pfam13604
278137000370	Family description; Region: UvrD_C_2; pfam13538
278137000371	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137000372	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137000373	metal binding site [ion binding]; metal-binding site
278137000374	active site
278137000375	I-site; other site
278137000376	MMPL family; Region: MMPL; pfam03176
278137000377	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137000378	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137000379	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
278137000380	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
278137000381	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
278137000382	catalytic residues [active]
278137000383	catalytic nucleophile [active]
278137000384	Presynaptic Site I dimer interface [polypeptide binding]; other site
278137000385	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
278137000386	Synaptic Flat tetramer interface [polypeptide binding]; other site
278137000387	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
278137000388	DNA-binding interface [nucleotide binding]; DNA binding site
278137000389	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137000390	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137000391	non-specific DNA binding site [nucleotide binding]; other site
278137000392	salt bridge; other site
278137000393	sequence-specific DNA binding site [nucleotide binding]; other site
278137000394	Domain of unknown function (DUF955); Region: DUF955; cl01076
278137000395	Abi-like protein; Region: Abi_2; pfam07751
278137000396	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
278137000397	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137000398	P-loop; other site
278137000399	Magnesium ion binding site [ion binding]; other site
278137000400	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
278137000401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137000402	Walker A motif; other site
278137000403	ATP binding site [chemical binding]; other site
278137000404	Walker B motif; other site
278137000405	arginine finger; other site
278137000406	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
278137000407	DnaA box-binding interface [nucleotide binding]; other site
278137000408	DNA polymerase III subunit beta; Validated; Region: PRK07761
278137000409	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
278137000410	putative DNA binding surface [nucleotide binding]; other site
278137000411	dimer interface [polypeptide binding]; other site
278137000412	beta-clamp/clamp loader binding surface; other site
278137000413	beta-clamp/translesion DNA polymerase binding surface; other site
278137000414	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
278137000415	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
278137000416	recombination protein F; Reviewed; Region: recF; PRK00064
278137000417	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
278137000418	Walker A/P-loop; other site
278137000419	ATP binding site [chemical binding]; other site
278137000420	Q-loop/lid; other site
278137000421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137000422	ABC transporter signature motif; other site
278137000423	Walker B; other site
278137000424	D-loop; other site
278137000425	H-loop/switch region; other site
278137000426	hypothetical protein; Provisional; Region: PRK03195
278137000427	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
278137000428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137000429	Mg2+ binding site [ion binding]; other site
278137000430	G-X-G motif; other site
278137000431	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
278137000432	anchoring element; other site
278137000433	dimer interface [polypeptide binding]; other site
278137000434	ATP binding site [chemical binding]; other site
278137000435	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
278137000436	active site
278137000437	putative metal-binding site [ion binding]; other site
278137000438	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
278137000439	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
278137000440	CAP-like domain; other site
278137000441	active site
278137000442	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
278137000443	protein-splicing catalytic site; other site
278137000444	thioester formation/cholesterol transfer; other site
278137000445	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
278137000446	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
278137000447	DNA gyrase subunit A; Validated; Region: PRK05560
278137000448	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
278137000449	primary dimer interface [polypeptide binding]; other site
278137000450	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
278137000451	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
278137000452	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
278137000453	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
278137000454	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
278137000455	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
278137000456	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
278137000457	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
278137000458	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
278137000459	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
278137000460	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
278137000461	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
278137000462	active site
278137000463	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
278137000464	putative septation inhibitor protein; Reviewed; Region: PRK00159
278137000465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
278137000466	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
278137000467	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
278137000468	Glutamine amidotransferase class-I; Region: GATase; pfam00117
278137000469	glutamine binding [chemical binding]; other site
278137000470	catalytic triad [active]
278137000471	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
278137000472	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137000473	active site
278137000474	ATP binding site [chemical binding]; other site
278137000475	substrate binding site [chemical binding]; other site
278137000476	activation loop (A-loop); other site
278137000477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
278137000478	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
278137000479	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
278137000480	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
278137000481	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
278137000482	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137000483	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137000484	active site
278137000485	ATP binding site [chemical binding]; other site
278137000486	substrate binding site [chemical binding]; other site
278137000487	activation loop (A-loop); other site
278137000488	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
278137000489	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
278137000490	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
278137000491	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
278137000492	active site
278137000493	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
278137000494	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
278137000495	phosphopeptide binding site; other site
278137000496	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
278137000497	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
278137000498	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
278137000499	phosphopeptide binding site; other site
278137000500	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
278137000501	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137000502	classical (c) SDRs; Region: SDR_c; cd05233
278137000503	NAD(P) binding site [chemical binding]; other site
278137000504	active site
278137000505	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
278137000506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137000507	NAD(P) binding site [chemical binding]; other site
278137000508	active site
278137000509	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
278137000510	oligomer interface [polypeptide binding]; other site
278137000511	putative active site [active]
278137000512	Mn binding site [ion binding]; other site
278137000513	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
278137000514	tetramer interface [polypeptide binding]; other site
278137000515	active site
278137000516	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
278137000517	ChaB; Region: ChaB; pfam06150
278137000518	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
278137000519	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
278137000520	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
278137000521	Predicted acetyltransferase [General function prediction only]; Region: COG2388
278137000522	Pirin-related protein [General function prediction only]; Region: COG1741
278137000523	Pirin; Region: Pirin; pfam02678
278137000524	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
278137000525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137000526	Coenzyme A binding pocket [chemical binding]; other site
278137000527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
278137000528	hypothetical protein; Provisional; Region: PRK02268
278137000529	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
278137000530	active site
278137000531	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137000532	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137000533	non-specific DNA binding site [nucleotide binding]; other site
278137000534	salt bridge; other site
278137000535	sequence-specific DNA binding site [nucleotide binding]; other site
278137000536	DivIVA domain; Region: DivI1A_domain; TIGR03544
278137000537	DivIVA domain; Region: DivI1A_domain; TIGR03544
278137000538	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137000539	MULE transposase domain; Region: MULE; pfam10551
278137000540	Uncharacterized conserved protein [Function unknown]; Region: COG3391
278137000541	Transcription factor WhiB; Region: Whib; pfam02467
278137000542	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
278137000543	EspG family; Region: ESX-1_EspG; pfam14011
278137000544	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
278137000545	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137000546	Walker A motif; other site
278137000547	ATP binding site [chemical binding]; other site
278137000548	Walker B motif; other site
278137000549	arginine finger; other site
278137000550	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
278137000551	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
278137000552	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137000553	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
278137000554	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137000555	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137000556	PE family; Region: PE; pfam00934
278137000557	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
278137000558	PPE family; Region: PPE; pfam00823
278137000559	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
278137000560	Proteins of 100 residues with WXG; Region: WXG100; cl02005
278137000561	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
278137000562	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137000563	P-loop; other site
278137000564	Magnesium ion binding site [ion binding]; other site
278137000565	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
278137000566	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
278137000567	PPE family; Region: PPE; pfam00823
278137000568	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
278137000569	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
278137000570	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
278137000571	active site
278137000572	catalytic residues [active]
278137000573	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
278137000574	ThiC-associated domain; Region: ThiC-associated; pfam13667
278137000575	ThiC family; Region: ThiC; pfam01964
278137000576	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
278137000577	dimerization domain swap beta strand [polypeptide binding]; other site
278137000578	regulatory protein interface [polypeptide binding]; other site
278137000579	active site
278137000580	regulatory phosphorylation site [posttranslational modification]; other site
278137000581	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
278137000582	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
278137000583	active site
278137000584	phosphorylation site [posttranslational modification]
278137000585	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
278137000586	active site
278137000587	P-loop; other site
278137000588	phosphorylation site [posttranslational modification]
278137000589	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
278137000590	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
278137000591	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
278137000592	putative substrate binding site [chemical binding]; other site
278137000593	putative ATP binding site [chemical binding]; other site
278137000594	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
278137000595	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
278137000596	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
278137000597	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
278137000598	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
278137000599	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
278137000600	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
278137000601	Pirin-related protein [General function prediction only]; Region: COG1741
278137000602	Pirin; Region: Pirin; pfam02678
278137000603	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
278137000604	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
278137000605	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137000606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137000607	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137000608	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137000609	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137000610	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
278137000611	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
278137000612	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
278137000613	NAD(P) binding site [chemical binding]; other site
278137000614	catalytic residues [active]
278137000615	short chain dehydrogenase; Provisional; Region: PRK07791
278137000616	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
278137000617	NAD binding site [chemical binding]; other site
278137000618	homodimer interface [polypeptide binding]; other site
278137000619	active site
278137000620	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
278137000621	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
278137000622	NAD(P) binding site [chemical binding]; other site
278137000623	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
278137000624	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
278137000625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137000626	S-adenosylmethionine binding site [chemical binding]; other site
278137000627	Protein of unknown function (DUF456); Region: DUF456; pfam04306
278137000628	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137000629	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137000630	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
278137000631	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
278137000632	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137000633	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
278137000634	FAD binding site [chemical binding]; other site
278137000635	substrate binding site [chemical binding]; other site
278137000636	catalytic base [active]
278137000637	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06069
278137000638	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
278137000639	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137000640	iron-sulfur cluster [ion binding]; other site
278137000641	[2Fe-2S] cluster binding site [ion binding]; other site
278137000642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137000643	Helix-turn-helix domain; Region: HTH_18; pfam12833
278137000644	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137000645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137000646	active site
278137000647	phosphorylation site [posttranslational modification]
278137000648	intermolecular recognition site; other site
278137000649	dimerization interface [polypeptide binding]; other site
278137000650	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137000651	DNA binding residues [nucleotide binding]
278137000652	dimerization interface [polypeptide binding]; other site
278137000653	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
278137000654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137000655	ATP binding site [chemical binding]; other site
278137000656	Mg2+ binding site [ion binding]; other site
278137000657	G-X-G motif; other site
278137000658	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
278137000659	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
278137000660	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
278137000661	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
278137000662	ligand binding site [chemical binding]; other site
278137000663	homodimer interface [polypeptide binding]; other site
278137000664	NAD(P) binding site [chemical binding]; other site
278137000665	trimer interface B [polypeptide binding]; other site
278137000666	trimer interface A [polypeptide binding]; other site
278137000667	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
278137000668	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
278137000669	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
278137000670	catalytic Zn binding site [ion binding]; other site
278137000671	NAD binding site [chemical binding]; other site
278137000672	structural Zn binding site [ion binding]; other site
278137000673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137000674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137000675	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
278137000676	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
278137000677	metal binding site [ion binding]; metal-binding site
278137000678	Protein of unknown function DUF72; Region: DUF72; pfam01904
278137000679	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
278137000680	putative hydrophobic ligand binding site [chemical binding]; other site
278137000681	Transcriptional regulators [Transcription]; Region: GntR; COG1802
278137000682	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137000683	DNA-binding site [nucleotide binding]; DNA binding site
278137000684	FCD domain; Region: FCD; pfam07729
278137000685	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
278137000686	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137000687	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137000688	acyl-activating enzyme (AAE) consensus motif; other site
278137000689	acyl-activating enzyme (AAE) consensus motif; other site
278137000690	putative AMP binding site [chemical binding]; other site
278137000691	putative active site [active]
278137000692	putative CoA binding site [chemical binding]; other site
278137000693	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137000694	Permease; Region: Permease; pfam02405
278137000695	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137000696	Permease; Region: Permease; pfam02405
278137000697	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000698	mce related protein; Region: MCE; pfam02470
278137000699	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137000700	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000701	mce related protein; Region: MCE; pfam02470
278137000702	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000703	mce related protein; Region: MCE; pfam02470
278137000704	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
278137000705	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
278137000706	mce related protein; Region: MCE; pfam02470
278137000707	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137000708	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000709	mce related protein; Region: MCE; pfam02470
278137000710	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
278137000711	mce related protein; Region: MCE; pfam02470
278137000712	RDD family; Region: RDD; pfam06271
278137000713	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
278137000714	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
278137000715	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
278137000716	Pirin-related protein [General function prediction only]; Region: COG1741
278137000717	Pirin; Region: Pirin; pfam02678
278137000718	Peptidase family M48; Region: Peptidase_M48; cl12018
278137000719	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137000720	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137000721	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137000722	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137000723	MULE transposase domain; Region: MULE; pfam10551
278137000724	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137000725	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
278137000726	Bacterial transcriptional regulator; Region: IclR; pfam01614
278137000727	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137000728	iron-sulfur cluster [ion binding]; other site
278137000729	[2Fe-2S] cluster binding site [ion binding]; other site
278137000730	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
278137000731	beta subunit interface [polypeptide binding]; other site
278137000732	alpha subunit interface [polypeptide binding]; other site
278137000733	active site
278137000734	substrate binding site [chemical binding]; other site
278137000735	Fe binding site [ion binding]; other site
278137000736	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137000737	inter-subunit interface; other site
278137000738	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
278137000739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137000740	NAD(P) binding site [chemical binding]; other site
278137000741	active site
278137000742	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137000743	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
278137000744	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
278137000745	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137000746	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
278137000747	Cupin domain; Region: Cupin_2; pfam07883
278137000748	Cupin domain; Region: Cupin_2; pfam07883
278137000749	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
278137000750	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
278137000751	putative active site [active]
278137000752	catalytic residue [active]
278137000753	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
278137000754	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
278137000755	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
278137000756	active site
278137000757	Fe binding site [ion binding]; other site
278137000758	SCP-2 sterol transfer family; Region: SCP2; pfam02036
278137000759	Class I aldolases; Region: Aldolase_Class_I; cl17187
278137000760	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
278137000761	catalytic residue [active]
278137000762	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137000763	inter-subunit interface; other site
278137000764	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
278137000765	L-aspartate oxidase; Provisional; Region: PRK06175
278137000766	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
278137000767	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
278137000768	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
278137000769	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137000770	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
278137000771	NAD(P) binding site [chemical binding]; other site
278137000772	catalytic residues [active]
278137000773	putative transposase OrfB; Reviewed; Region: PHA02517
278137000774	HTH-like domain; Region: HTH_21; pfam13276
278137000775	Integrase core domain; Region: rve; pfam00665
278137000776	Integrase core domain; Region: rve_3; pfam13683
278137000777	Transposase; Region: HTH_Tnp_1; cl17663
278137000778	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137000779	inter-subunit interface; other site
278137000780	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137000781	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
278137000782	alpha subunit interaction site [polypeptide binding]; other site
278137000783	beta subunit interaction site [polypeptide binding]; other site
278137000784	iron-sulfur cluster [ion binding]; other site
278137000785	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
278137000786	beta subunit interface [polypeptide binding]; other site
278137000787	alpha subunit interface [polypeptide binding]; other site
278137000788	active site
278137000789	substrate binding site [chemical binding]; other site
278137000790	Fe binding site [ion binding]; other site
278137000791	short chain dehydrogenase; Provisional; Region: PRK06138
278137000792	classical (c) SDRs; Region: SDR_c; cd05233
278137000793	NAD(P) binding site [chemical binding]; other site
278137000794	active site
278137000795	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137000796	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
278137000797	putative NAD(P) binding site [chemical binding]; other site
278137000798	catalytic Zn binding site [ion binding]; other site
278137000799	VPS10 domain; Region: VPS10; smart00602
278137000800	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137000801	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137000802	[2Fe-2S] cluster binding site [ion binding]; other site
278137000803	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
278137000804	hydrophobic ligand binding site; other site
278137000805	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137000806	SCP-2 sterol transfer family; Region: SCP2; cl01225
278137000807	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
278137000808	active site
278137000809	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137000810	Permease; Region: Permease; pfam02405
278137000811	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137000812	Permease; Region: Permease; pfam02405
278137000813	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000814	mce related protein; Region: MCE; pfam02470
278137000815	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137000816	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000817	mce related protein; Region: MCE; pfam02470
278137000818	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137000819	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000820	mce related protein; Region: MCE; pfam02470
278137000821	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000822	mce related protein; Region: MCE; pfam02470
278137000823	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137000824	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000825	mce related protein; Region: MCE; pfam02470
278137000826	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137000827	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137000828	mce related protein; Region: MCE; pfam02470
278137000829	Epoxide hydrolase N terminus; Region: EHN; pfam06441
278137000830	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137000831	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137000832	Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107
278137000833	NAD(P) binding site [chemical binding]; other site
278137000834	catalytic residues [active]
278137000835	catalytic residues [active]
278137000836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137000837	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137000838	putative substrate translocation pore; other site
278137000839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
278137000840	MarR family; Region: MarR; pfam01047
278137000841	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137000842	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
278137000843	alpha subunit interaction site [polypeptide binding]; other site
278137000844	beta subunit interaction site [polypeptide binding]; other site
278137000845	iron-sulfur cluster [ion binding]; other site
278137000846	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
278137000847	beta subunit interface [polypeptide binding]; other site
278137000848	alpha subunit interface [polypeptide binding]; other site
278137000849	active site
278137000850	substrate binding site [chemical binding]; other site
278137000851	Fe binding site [ion binding]; other site
278137000852	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137000853	inter-subunit interface; other site
278137000854	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137000855	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
278137000856	putative NAD(P) binding site [chemical binding]; other site
278137000857	catalytic Zn binding site [ion binding]; other site
278137000858	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137000859	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137000860	lipid-transfer protein; Provisional; Region: PRK07855
278137000861	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137000862	active site
278137000863	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
278137000864	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137000865	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137000866	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
278137000867	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137000868	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
278137000869	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137000870	iron-sulfur cluster [ion binding]; other site
278137000871	[2Fe-2S] cluster binding site [ion binding]; other site
278137000872	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
278137000873	beta subunit interface [polypeptide binding]; other site
278137000874	alpha subunit interface [polypeptide binding]; other site
278137000875	active site
278137000876	substrate binding site [chemical binding]; other site
278137000877	Fe binding site [ion binding]; other site
278137000878	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137000879	inter-subunit interface; other site
278137000880	Cupin domain; Region: Cupin_2; pfam07883
278137000881	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
278137000882	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137000883	MarR family; Region: MarR; pfam01047
278137000884	MarR family; Region: MarR_2; cl17246
278137000885	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137000886	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137000887	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137000888	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137000889	iron-sulfur cluster [ion binding]; other site
278137000890	[2Fe-2S] cluster binding site [ion binding]; other site
278137000891	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
278137000892	beta subunit interface [polypeptide binding]; other site
278137000893	alpha subunit interface [polypeptide binding]; other site
278137000894	active site
278137000895	substrate binding site [chemical binding]; other site
278137000896	Fe binding site [ion binding]; other site
278137000897	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137000898	inter-subunit interface; other site
278137000899	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
278137000900	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
278137000901	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
278137000902	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
278137000903	active site
278137000904	metal binding site [ion binding]; metal-binding site
278137000905	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
278137000906	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
278137000907	intersubunit interface [polypeptide binding]; other site
278137000908	active site
278137000909	Zn2+ binding site [ion binding]; other site
278137000910	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
278137000911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137000912	NAD(P) binding site [chemical binding]; other site
278137000913	active site
278137000914	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
278137000915	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
278137000916	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
278137000917	active site
278137000918	Fe binding site [ion binding]; other site
278137000919	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
278137000920	alpha subunit interaction site [polypeptide binding]; other site
278137000921	beta subunit interaction site [polypeptide binding]; other site
278137000922	iron-sulfur cluster [ion binding]; other site
278137000923	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
278137000924	beta subunit interface [polypeptide binding]; other site
278137000925	alpha subunit interface [polypeptide binding]; other site
278137000926	active site
278137000927	substrate binding site [chemical binding]; other site
278137000928	Fe binding site [ion binding]; other site
278137000929	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137000930	inter-subunit interface; other site
278137000931	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137000932	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137000933	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137000934	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137000935	MULE transposase domain; Region: MULE; pfam10551
278137000936	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
278137000937	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137000938	Transposase; Region: HTH_Tnp_1; pfam01527
278137000939	HTH-like domain; Region: HTH_21; pfam13276
278137000940	Integrase core domain; Region: rve; pfam00665
278137000941	Integrase core domain; Region: rve_3; pfam13683
278137000942	putative transposase OrfB; Reviewed; Region: PHA02517
278137000943	HTH-like domain; Region: HTH_21; pfam13276
278137000944	Integrase core domain; Region: rve; pfam00665
278137000945	Integrase core domain; Region: rve_3; pfam13683
278137000946	Transposase; Region: HTH_Tnp_1; cl17663
278137000947	putative transposase OrfB; Reviewed; Region: PHA02517
278137000948	HTH-like domain; Region: HTH_21; pfam13276
278137000949	Integrase core domain; Region: rve; pfam00665
278137000950	Integrase core domain; Region: rve_3; cl15866
278137000951	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137000952	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137000953	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137000954	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
278137000955	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
278137000956	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
278137000957	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
278137000958	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
278137000959	active site
278137000960	inhibitor site; inhibition site
278137000961	dimer interface [polypeptide binding]; other site
278137000962	catalytic residue [active]
278137000963	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137000964	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
278137000965	Bacterial transcriptional regulator; Region: IclR; pfam01614
278137000966	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
278137000967	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
278137000968	active site
278137000969	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
278137000970	active site
278137000971	3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426
278137000972	Lyase; Region: Lyase_1; pfam00206
278137000973	tetramer interface [polypeptide binding]; other site
278137000974	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137000975	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
278137000976	Coenzyme A transferase; Region: CoA_trans; cl17247
278137000977	Coenzyme A transferase; Region: CoA_trans; cl17247
278137000978	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
278137000979	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
278137000980	Cupin domain; Region: Cupin_2; pfam07883
278137000981	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137000982	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137000983	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137000984	putative DNA binding site [nucleotide binding]; other site
278137000985	putative Zn2+ binding site [ion binding]; other site
278137000986	RNA polymerase factor sigma-70; Validated; Region: PRK08241
278137000987	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137000988	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137000989	DNA binding residues [nucleotide binding]
278137000990	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137000991	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
278137000992	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137000993	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
278137000994	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
278137000995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137000996	S-adenosylmethionine binding site [chemical binding]; other site
278137000997	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137000998	Transposase; Region: HTH_Tnp_1; pfam01527
278137000999	putative transposase OrfB; Reviewed; Region: PHA02517
278137001000	HTH-like domain; Region: HTH_21; pfam13276
278137001001	Integrase core domain; Region: rve; pfam00665
278137001002	Integrase core domain; Region: rve_3; pfam13683
278137001003	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
278137001004	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
278137001005	putative hydrophobic ligand binding site [chemical binding]; other site
278137001006	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
278137001007	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
278137001008	VCBS repeat; Region: VCBS_repeat; TIGR01965
278137001009	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
278137001010	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
278137001011	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
278137001012	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
278137001013	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
278137001014	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
278137001015	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
278137001016	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
278137001017	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
278137001018	fructuronate transporter; Provisional; Region: PRK10034; cl15264
278137001019	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
278137001020	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
278137001021	ATP-binding site [chemical binding]; other site
278137001022	Gluconate-6-phosphate binding site [chemical binding]; other site
278137001023	Transcriptional regulators [Transcription]; Region: FadR; COG2186
278137001024	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
278137001025	DNA-binding site [nucleotide binding]; DNA binding site
278137001026	FCD domain; Region: FCD; pfam07729
278137001027	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
278137001028	CAP-like domain; other site
278137001029	DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521
278137001030	active site
278137001031	primary dimer interface [polypeptide binding]; other site
278137001032	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
278137001033	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
278137001034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137001035	Mg2+ binding site [ion binding]; other site
278137001036	G-X-G motif; other site
278137001037	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
278137001038	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
278137001039	active site
278137001040	metal binding site [ion binding]; metal-binding site
278137001041	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
278137001042	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
278137001043	Beta-lactamase; Region: Beta-lactamase; pfam00144
278137001044	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
278137001045	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
278137001046	phosphoenolpyruvate synthase; Validated; Region: PRK06241
278137001047	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
278137001048	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
278137001049	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001050	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001051	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
278137001052	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
278137001053	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
278137001054	Domain of unknown function (DUF305); Region: DUF305; pfam03713
278137001055	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
278137001056	putative homotetramer interface [polypeptide binding]; other site
278137001057	putative homodimer interface [polypeptide binding]; other site
278137001058	putative allosteric switch controlling residues; other site
278137001059	putative metal binding site [ion binding]; other site
278137001060	putative homodimer-homodimer interface [polypeptide binding]; other site
278137001061	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
278137001062	putative ADP-binding pocket [chemical binding]; other site
278137001063	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137001064	Domain of unknown function DUF77; Region: DUF77; pfam01910
278137001065	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137001066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137001067	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137001068	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
278137001069	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
278137001070	active site
278137001071	Zn binding site [ion binding]; other site
278137001072	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
278137001073	RibD C-terminal domain; Region: RibD_C; cl17279
278137001074	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
278137001075	MMPL family; Region: MMPL; pfam03176
278137001076	MMPL family; Region: MMPL; pfam03176
278137001077	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
278137001078	active site
278137001079	TDP-binding site; other site
278137001080	acceptor substrate-binding pocket; other site
278137001081	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137001082	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137001083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137001084	active site
278137001085	phosphorylation site [posttranslational modification]
278137001086	intermolecular recognition site; other site
278137001087	dimerization interface [polypeptide binding]; other site
278137001088	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137001089	DNA binding site [nucleotide binding]
278137001090	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137001091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137001092	phosphorylation site [posttranslational modification]
278137001093	dimer interface [polypeptide binding]; other site
278137001094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137001095	ATP binding site [chemical binding]; other site
278137001096	Mg2+ binding site [ion binding]; other site
278137001097	G-X-G motif; other site
278137001098	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
278137001099	Predicted integral membrane protein [Function unknown]; Region: COG0392
278137001100	Domain of unknown function DUF20; Region: UPF0118; pfam01594
278137001101	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
278137001102	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137001103	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
278137001104	MMPL family; Region: MMPL; pfam03176
278137001105	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
278137001106	LabA_like proteins; Region: LabA_like; cd06167
278137001107	putative metal binding site [ion binding]; other site
278137001108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137001109	S-adenosylmethionine binding site [chemical binding]; other site
278137001110	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
278137001111	active site
278137001112	substrate-binding site [chemical binding]; other site
278137001113	metal-binding site [ion binding]
278137001114	GTP binding site [chemical binding]; other site
278137001115	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137001116	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
278137001117	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137001118	acyl-activating enzyme (AAE) consensus motif; other site
278137001119	acyl-activating enzyme (AAE) consensus motif; other site
278137001120	putative AMP binding site [chemical binding]; other site
278137001121	putative active site [active]
278137001122	putative CoA binding site [chemical binding]; other site
278137001123	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137001124	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137001125	substrate binding site [chemical binding]; other site
278137001126	oxyanion hole (OAH) forming residues; other site
278137001127	trimer interface [polypeptide binding]; other site
278137001128	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
278137001129	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137001130	DNA-binding site [nucleotide binding]; DNA binding site
278137001131	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
278137001132	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001133	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137001134	active site
278137001135	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137001136	active site 2 [active]
278137001137	active site 1 [active]
278137001138	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137001139	active site 2 [active]
278137001140	active site 1 [active]
278137001141	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137001142	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137001143	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137001144	active site
278137001145	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137001146	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137001147	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001148	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137001149	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137001150	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001151	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137001152	active site
278137001153	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137001154	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137001155	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137001156	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137001157	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137001158	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
278137001159	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001160	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001161	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
278137001162	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137001163	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137001164	acyl-CoA synthetase; Provisional; Region: PRK13382
278137001165	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137001166	acyl-activating enzyme (AAE) consensus motif; other site
278137001167	putative AMP binding site [chemical binding]; other site
278137001168	putative active site [active]
278137001169	putative CoA binding site [chemical binding]; other site
278137001170	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137001171	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
278137001172	putative acyl-acceptor binding pocket; other site
278137001173	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
278137001174	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137001175	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137001176	DinB superfamily; Region: DinB_2; pfam12867
278137001177	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
278137001178	RibD C-terminal domain; Region: RibD_C; cl17279
278137001179	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
278137001180	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
278137001181	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
278137001182	FAD binding site [chemical binding]; other site
278137001183	substrate binding site [chemical binding]; other site
278137001184	catalytic residues [active]
278137001185	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
278137001186	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
278137001187	SnoaL-like domain; Region: SnoaL_3; pfam13474
278137001188	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
278137001189	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137001190	NAD binding site [chemical binding]; other site
278137001191	catalytic residues [active]
278137001192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137001193	S-adenosylmethionine binding site [chemical binding]; other site
278137001194	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137001195	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
278137001196	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137001197	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137001198	Cytochrome P450; Region: p450; cl12078
278137001199	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
278137001200	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
278137001201	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137001202	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
278137001203	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
278137001204	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
278137001205	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137001206	Ligand Binding Site [chemical binding]; other site
278137001207	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
278137001208	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
278137001209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001211	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137001212	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137001213	active site 2 [active]
278137001214	active site 1 [active]
278137001215	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
278137001216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137001217	NAD(P) binding site [chemical binding]; other site
278137001218	active site
278137001219	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
278137001220	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137001221	dimer interface [polypeptide binding]; other site
278137001222	active site
278137001223	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
278137001224	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137001225	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
278137001226	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
278137001227	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
278137001228	FAD binding site [chemical binding]; other site
278137001229	substrate binding site [chemical binding]; other site
278137001230	catalytic residues [active]
278137001231	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
278137001232	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137001233	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137001234	short chain dehydrogenase; Provisional; Region: PRK08267
278137001235	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137001236	NAD(P) binding site [chemical binding]; other site
278137001237	active site
278137001238	TspO/MBR family; Region: TspO_MBR; pfam03073
278137001239	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
278137001240	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137001241	active site
278137001242	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
278137001243	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137001244	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
278137001245	KR domain; Region: KR; pfam08659
278137001246	putative NADP binding site [chemical binding]; other site
278137001247	active site
278137001248	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137001249	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
278137001250	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137001251	active site
278137001252	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137001253	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
278137001254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137001255	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
278137001256	Enoylreductase; Region: PKS_ER; smart00829
278137001257	NAD(P) binding site [chemical binding]; other site
278137001258	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
278137001259	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
278137001260	putative NADP binding site [chemical binding]; other site
278137001261	active site
278137001262	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137001263	Transport protein; Region: actII; TIGR00833
278137001264	acyl-CoA synthetase; Validated; Region: PRK05850
278137001265	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
278137001266	acyl-activating enzyme (AAE) consensus motif; other site
278137001267	active site
278137001268	PE-PPE domain; Region: PE-PPE; pfam08237
278137001269	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
278137001270	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
278137001271	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001272	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137001273	active site
278137001274	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
278137001275	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137001276	putative DNA binding site [nucleotide binding]; other site
278137001277	putative Zn2+ binding site [ion binding]; other site
278137001278	AsnC family; Region: AsnC_trans_reg; pfam01037
278137001279	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
278137001280	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137001281	catalytic loop [active]
278137001282	iron binding site [ion binding]; other site
278137001283	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
278137001284	L-aspartate oxidase; Provisional; Region: PRK06175
278137001285	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
278137001286	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
278137001287	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
278137001288	tetramer interface [polypeptide binding]; other site
278137001289	active site
278137001290	Mg2+/Mn2+ binding site [ion binding]; other site
278137001291	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137001292	Ligand Binding Site [chemical binding]; other site
278137001293	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
278137001294	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
278137001295	putative dimer interface [polypeptide binding]; other site
278137001296	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
278137001297	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137001298	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137001299	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
278137001300	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
278137001301	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
278137001302	Integrase core domain; Region: rve; pfam00665
278137001303	Integrase core domain; Region: rve_3; pfam13683
278137001304	Ferredoxin [Energy production and conversion]; Region: COG1146
278137001305	4Fe-4S binding domain; Region: Fer4; cl02805
278137001306	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
278137001307	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
278137001308	putative active site [active]
278137001309	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
278137001310	putative active site [active]
278137001311	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
278137001312	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
278137001313	active site
278137001314	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
278137001315	DNA binding site [nucleotide binding]
278137001316	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137001317	Coenzyme A binding pocket [chemical binding]; other site
278137001318	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
278137001319	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
278137001320	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
278137001321	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
278137001322	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
278137001323	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
278137001324	intersubunit interface [polypeptide binding]; other site
278137001325	Lysine efflux permease [General function prediction only]; Region: COG1279
278137001326	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
278137001327	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137001328	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137001329	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137001330	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
278137001331	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137001332	NAD(P) binding site [chemical binding]; other site
278137001333	active site
278137001334	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001335	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001336	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137001337	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001338	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
278137001339	DNA-binding interface [nucleotide binding]; DNA binding site
278137001340	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137001341	Cytochrome P450; Region: p450; cl12078
278137001342	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
278137001343	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137001344	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
278137001345	dimerization interface [polypeptide binding]; other site
278137001346	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
278137001347	active site
278137001348	SAM binding site [chemical binding]; other site
278137001349	homodimer interface [polypeptide binding]; other site
278137001350	cobyric acid synthase; Provisional; Region: PRK00784
278137001351	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
278137001352	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
278137001353	catalytic triad [active]
278137001354	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
278137001355	hypothetical protein; Provisional; Region: PRK06062
278137001356	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137001357	inhibitor-cofactor binding pocket; inhibition site
278137001358	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137001359	catalytic residue [active]
278137001360	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
278137001361	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
278137001362	tetrameric interface [polypeptide binding]; other site
278137001363	NAD binding site [chemical binding]; other site
278137001364	catalytic residues [active]
278137001365	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
278137001366	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
278137001367	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
278137001368	homotrimer interface [polypeptide binding]; other site
278137001369	Walker A motif; other site
278137001370	GTP binding site [chemical binding]; other site
278137001371	Walker B motif; other site
278137001372	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
278137001373	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
278137001374	putative FMN binding site [chemical binding]; other site
278137001375	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
278137001376	active site
278137001377	SAM binding site [chemical binding]; other site
278137001378	homodimer interface [polypeptide binding]; other site
278137001379	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137001380	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
278137001381	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001382	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
278137001383	Flavodoxin; Region: Flavodoxin_1; pfam00258
278137001384	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
278137001385	FAD binding pocket [chemical binding]; other site
278137001386	conserved FAD binding motif [chemical binding]; other site
278137001387	phosphate binding motif [ion binding]; other site
278137001388	beta-alpha-beta structure motif; other site
278137001389	NAD binding pocket [chemical binding]; other site
278137001390	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
278137001391	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001392	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137001393	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137001394	active site
278137001395	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001396	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137001397	active site
278137001398	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137001399	anti sigma factor interaction site; other site
278137001400	regulatory phosphorylation site [posttranslational modification]; other site
278137001401	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
278137001402	nucleotide binding site [chemical binding]; other site
278137001403	acyl-CoA synthetase; Validated; Region: PRK07788
278137001404	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137001405	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137001406	active site
278137001407	CoA binding site [chemical binding]; other site
278137001408	AMP binding site [chemical binding]; other site
278137001409	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
278137001410	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
278137001411	NAD binding site [chemical binding]; other site
278137001412	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
278137001413	putative dimer interface [polypeptide binding]; other site
278137001414	putative [2Fe-2S] cluster binding site [ion binding]; other site
278137001415	Cupin superfamily protein; Region: Cupin_4; pfam08007
278137001416	Cupin-like domain; Region: Cupin_8; pfam13621
278137001417	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001418	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137001419	active site
278137001420	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137001421	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
278137001422	FAD binding site [chemical binding]; other site
278137001423	substrate binding site [chemical binding]; other site
278137001424	catalytic base [active]
278137001425	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
278137001426	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175
278137001427	putative ligand binding site [chemical binding]; other site
278137001428	putative NAD binding site [chemical binding]; other site
278137001429	catalytic site [active]
278137001430	Esterase/lipase [General function prediction only]; Region: COG1647
278137001431	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
278137001432	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137001433	Zn binding site [ion binding]; other site
278137001434	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
278137001435	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
278137001436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137001437	Walker A motif; other site
278137001438	ATP binding site [chemical binding]; other site
278137001439	Walker B motif; other site
278137001440	arginine finger; other site
278137001441	Protein of unknown function (DUF690); Region: DUF690; cl04939
278137001442	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
278137001443	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137001444	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
278137001445	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137001446	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
278137001447	PPE family; Region: PPE; pfam00823
278137001448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
278137001449	EspG family; Region: ESX-1_EspG; pfam14011
278137001450	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
278137001451	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
278137001452	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
278137001453	active site
278137001454	catalytic residues [active]
278137001455	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
278137001456	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137001457	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
278137001458	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
278137001459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137001460	S-adenosylmethionine binding site [chemical binding]; other site
278137001461	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137001462	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137001463	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137001464	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137001465	active site
278137001466	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
278137001467	active site
278137001468	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
278137001469	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
278137001470	active site
278137001471	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
278137001472	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
278137001473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
278137001474	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137001475	SnoaL-like domain; Region: SnoaL_3; pfam13474
278137001476	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137001477	nucleotide binding site [chemical binding]; other site
278137001478	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
278137001479	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
278137001480	NAD binding site [chemical binding]; other site
278137001481	dimer interface [polypeptide binding]; other site
278137001482	substrate binding site [chemical binding]; other site
278137001483	tetramer (dimer of dimers) interface [polypeptide binding]; other site
278137001484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137001485	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137001486	NAD(P) binding site [chemical binding]; other site
278137001487	active site
278137001488	hypothetical protein; Provisional; Region: PRK06185
278137001489	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
278137001490	Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080
278137001491	putative catalytic site [active]
278137001492	putative metal binding site [ion binding]; other site
278137001493	putative phosphate binding site [ion binding]; other site
278137001494	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
278137001495	heme-binding site [chemical binding]; other site
278137001496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137001497	putative substrate translocation pore; other site
278137001498	PGAP1-like protein; Region: PGAP1; pfam07819
278137001499	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
278137001500	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
278137001501	active site
278137001502	catalytic residues [active]
278137001503	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001505	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137001506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137001507	NAD(P) binding site [chemical binding]; other site
278137001508	active site
278137001509	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
278137001510	Fic family protein [Function unknown]; Region: COG3177
278137001511	Fic/DOC family; Region: Fic; pfam02661
278137001512	Phage capsid family; Region: Phage_capsid; pfam05065
278137001513	Protein of unknown function (DUF2742); Region: DUF2742; pfam10888
278137001514	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
278137001515	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
278137001516	Int/Topo IB signature motif; other site
278137001517	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
278137001518	trimer interface [polypeptide binding]; other site
278137001519	active site
278137001520	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
278137001521	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
278137001522	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
278137001523	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
278137001524	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
278137001525	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
278137001526	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
278137001527	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137001528	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
278137001529	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
278137001530	substrate binding site; other site
278137001531	tetramer interface; other site
278137001532	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
278137001533	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
278137001534	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
278137001535	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
278137001536	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
278137001537	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
278137001538	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137001539	catalytic loop [active]
278137001540	iron binding site [ion binding]; other site
278137001541	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
278137001542	YibE/F-like protein; Region: YibE_F; pfam07907
278137001543	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
278137001544	aminotransferase AlaT; Validated; Region: PRK09265
278137001545	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137001546	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137001547	homodimer interface [polypeptide binding]; other site
278137001548	catalytic residue [active]
278137001549	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137001550	4Fe-4S binding domain; Region: Fer4; cl02805
278137001551	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
278137001552	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
278137001553	4Fe-4S binding domain; Region: Fer4; pfam00037
278137001554	Cysteine-rich domain; Region: CCG; pfam02754
278137001555	Cysteine-rich domain; Region: CCG; pfam02754
278137001556	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137001557	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137001558	DNA binding residues [nucleotide binding]
278137001559	dimerization interface [polypeptide binding]; other site
278137001560	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
278137001561	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137001562	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
278137001563	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
278137001564	G1 box; other site
278137001565	GTP/Mg2+ binding site [chemical binding]; other site
278137001566	G2 box; other site
278137001567	Switch I region; other site
278137001568	G3 box; other site
278137001569	Switch II region; other site
278137001570	G4 box; other site
278137001571	G5 box; other site
278137001572	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
278137001573	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
278137001574	G1 box; other site
278137001575	GTP/Mg2+ binding site [chemical binding]; other site
278137001576	G2 box; other site
278137001577	Switch I region; other site
278137001578	G3 box; other site
278137001579	Switch II region; other site
278137001580	G4 box; other site
278137001581	G5 box; other site
278137001582	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137001583	nucleotide binding site [chemical binding]; other site
278137001584	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
278137001585	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137001586	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137001587	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137001588	TIGR03085 family protein; Region: TIGR03085
278137001589	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
278137001590	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
278137001591	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
278137001592	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
278137001593	mycothione reductase; Reviewed; Region: PRK07846
278137001594	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137001595	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
278137001596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
278137001597	Predicted kinase [General function prediction only]; Region: COG0645
278137001598	AAA domain; Region: AAA_17; pfam13207
278137001599	pyruvate kinase; Provisional; Region: PRK14725
278137001600	active site
278137001601	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
278137001602	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
278137001603	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
278137001604	nucleotide binding site [chemical binding]; other site
278137001605	NEF interaction site [polypeptide binding]; other site
278137001606	SBD interface [polypeptide binding]; other site
278137001607	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
278137001608	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
278137001609	dimer interface [polypeptide binding]; other site
278137001610	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
278137001611	chaperone protein DnaJ; Provisional; Region: PRK14279
278137001612	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
278137001613	HSP70 interaction site [polypeptide binding]; other site
278137001614	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
278137001615	Zn binding sites [ion binding]; other site
278137001616	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
278137001617	dimer interface [polypeptide binding]; other site
278137001618	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
278137001619	DNA binding residues [nucleotide binding]
278137001620	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
278137001621	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
278137001622	active site
278137001623	catalytic residues [active]
278137001624	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
278137001625	heme-binding site [chemical binding]; other site
278137001626	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
278137001627	FMN reductase; Validated; Region: fre; PRK08051
278137001628	FAD binding pocket [chemical binding]; other site
278137001629	FAD binding motif [chemical binding]; other site
278137001630	phosphate binding motif [ion binding]; other site
278137001631	beta-alpha-beta structure motif; other site
278137001632	NAD binding pocket [chemical binding]; other site
278137001633	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001634	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
278137001635	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
278137001636	active site
278137001637	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
278137001638	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
278137001639	active site
278137001640	non-prolyl cis peptide bond; other site
278137001641	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
278137001642	Na binding site [ion binding]; other site
278137001643	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
278137001644	putative active site [active]
278137001645	putative metal binding residues [ion binding]; other site
278137001646	signature motif; other site
278137001647	putative dimer interface [polypeptide binding]; other site
278137001648	putative phosphate binding site [ion binding]; other site
278137001649	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
278137001650	Clp amino terminal domain; Region: Clp_N; pfam02861
278137001651	Clp amino terminal domain; Region: Clp_N; pfam02861
278137001652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137001653	Walker A motif; other site
278137001654	ATP binding site [chemical binding]; other site
278137001655	Walker B motif; other site
278137001656	arginine finger; other site
278137001657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137001658	Walker A motif; other site
278137001659	ATP binding site [chemical binding]; other site
278137001660	Walker B motif; other site
278137001661	arginine finger; other site
278137001662	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
278137001663	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
278137001664	classical (c) SDRs; Region: SDR_c; cd05233
278137001665	NAD(P) binding site [chemical binding]; other site
278137001666	active site
278137001667	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
278137001668	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
278137001669	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
278137001670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137001671	putative substrate translocation pore; other site
278137001672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137001673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001675	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
278137001676	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
278137001677	Thioredoxin; Region: Thioredoxin_4; pfam13462
278137001678	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
278137001679	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
278137001680	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
278137001681	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
278137001682	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
278137001683	NAD(P) binding site [chemical binding]; other site
278137001684	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
278137001685	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
278137001686	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
278137001687	active site
278137001688	intersubunit interface [polypeptide binding]; other site
278137001689	zinc binding site [ion binding]; other site
278137001690	Na+ binding site [ion binding]; other site
278137001691	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
278137001692	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
278137001693	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
278137001694	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
278137001695	Peptidase family M50; Region: Peptidase_M50; pfam02163
278137001696	active site
278137001697	putative substrate binding region [chemical binding]; other site
278137001698	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
278137001699	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
278137001700	GDP-binding site [chemical binding]; other site
278137001701	ACT binding site; other site
278137001702	IMP binding site; other site
278137001703	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137001704	CoenzymeA binding site [chemical binding]; other site
278137001705	subunit interaction site [polypeptide binding]; other site
278137001706	PHB binding site; other site
278137001707	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137001708	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137001709	Cytochrome P450; Region: p450; cl12078
278137001710	MMPL family; Region: MMPL; pfam03176
278137001711	Transcriptional regulators [Transcription]; Region: MarR; COG1846
278137001712	MarR family; Region: MarR_2; pfam12802
278137001713	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
278137001714	ATP-grasp domain; Region: ATP-grasp_4; cl17255
278137001715	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
278137001716	active site residue [active]
278137001717	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
278137001718	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
278137001719	homodimer interface [polypeptide binding]; other site
278137001720	substrate-cofactor binding pocket; other site
278137001721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137001722	catalytic residue [active]
278137001723	short chain dehydrogenase; Provisional; Region: PRK07825
278137001724	classical (c) SDRs; Region: SDR_c; cd05233
278137001725	NAD(P) binding site [chemical binding]; other site
278137001726	active site
278137001727	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137001728	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
278137001729	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
278137001730	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
278137001731	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137001732	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
278137001733	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137001734	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
278137001735	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
278137001736	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137001737	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
278137001738	putative catalytic site [active]
278137001739	putative phosphate binding site [ion binding]; other site
278137001740	putative metal binding site [ion binding]; other site
278137001741	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
278137001742	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
278137001743	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
278137001744	DXD motif; other site
278137001745	phosphate acetyltransferase; Reviewed; Region: PRK05632
278137001746	DRTGG domain; Region: DRTGG; pfam07085
278137001747	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
278137001748	propionate/acetate kinase; Provisional; Region: PRK12379
278137001749	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
278137001750	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137001751	anti sigma factor interaction site; other site
278137001752	regulatory phosphorylation site [posttranslational modification]; other site
278137001753	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137001754	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137001755	active site
278137001756	ATP binding site [chemical binding]; other site
278137001757	substrate binding site [chemical binding]; other site
278137001758	activation loop (A-loop); other site
278137001759	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137001760	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137001761	substrate binding pocket [chemical binding]; other site
278137001762	membrane-bound complex binding site; other site
278137001763	hinge residues; other site
278137001764	CobD/Cbib protein; Region: CobD_Cbib; cl00561
278137001765	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
278137001766	nudix motif; other site
278137001767	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
278137001768	thiamine phosphate binding site [chemical binding]; other site
278137001769	active site
278137001770	pyrophosphate binding site [ion binding]; other site
278137001771	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
278137001772	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
278137001773	thiS-thiF/thiG interaction site; other site
278137001774	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
278137001775	ThiS interaction site; other site
278137001776	putative active site [active]
278137001777	tetramer interface [polypeptide binding]; other site
278137001778	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
278137001779	active site
278137001780	catalytic triad [active]
278137001781	oxyanion hole [active]
278137001782	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
278137001783	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137001784	Walker A/P-loop; other site
278137001785	ATP binding site [chemical binding]; other site
278137001786	Q-loop/lid; other site
278137001787	ABC transporter signature motif; other site
278137001788	Walker B; other site
278137001789	D-loop; other site
278137001790	H-loop/switch region; other site
278137001791	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137001792	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
278137001793	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
278137001794	PA/protease or protease-like domain interface [polypeptide binding]; other site
278137001795	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
278137001796	Peptidase family M28; Region: Peptidase_M28; pfam04389
278137001797	active site
278137001798	metal binding site [ion binding]; metal-binding site
278137001799	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
278137001800	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
278137001801	PA/protease or protease-like domain interface [polypeptide binding]; other site
278137001802	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
278137001803	Peptidase family M28; Region: Peptidase_M28; pfam04389
278137001804	active site
278137001805	metal binding site [ion binding]; metal-binding site
278137001806	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
278137001807	amino acid transporter; Region: 2A0306; TIGR00909
278137001808	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001809	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001810	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001811	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001812	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137001813	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137001814	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
278137001815	Septum formation; Region: Septum_form; pfam13845
278137001816	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
278137001817	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137001818	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
278137001819	dimer interface [polypeptide binding]; other site
278137001820	substrate binding site [chemical binding]; other site
278137001821	ATP binding site [chemical binding]; other site
278137001822	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137001823	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137001824	active site
278137001825	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
278137001826	putative catalytic site [active]
278137001827	putative phosphate binding site [ion binding]; other site
278137001828	active site
278137001829	metal binding site A [ion binding]; metal-binding site
278137001830	DNA binding site [nucleotide binding]
278137001831	putative AP binding site [nucleotide binding]; other site
278137001832	putative metal binding site B [ion binding]; other site
278137001833	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
278137001834	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137001835	Coenzyme A binding pocket [chemical binding]; other site
278137001836	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
278137001837	active site
278137001838	catalytic residues [active]
278137001839	metal binding site [ion binding]; metal-binding site
278137001840	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
278137001841	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
278137001842	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
278137001843	E-class dimer interface [polypeptide binding]; other site
278137001844	P-class dimer interface [polypeptide binding]; other site
278137001845	active site
278137001846	Cu2+ binding site [ion binding]; other site
278137001847	Zn2+ binding site [ion binding]; other site
278137001848	carboxylate-amine ligase; Provisional; Region: PRK13517
278137001849	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
278137001850	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
278137001851	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137001852	Leucine carboxyl methyltransferase; Region: LCM; cl01306
278137001853	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
278137001854	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
278137001855	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
278137001856	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
278137001857	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
278137001858	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
278137001859	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
278137001860	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
278137001861	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
278137001862	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
278137001863	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
278137001864	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
278137001865	TrkA-N domain; Region: TrkA_N; pfam02254
278137001866	TrkA-C domain; Region: TrkA_C; pfam02080
278137001867	potassium/proton antiporter; Reviewed; Region: PRK05326
278137001868	TrkA-C domain; Region: TrkA_C; pfam02080
278137001869	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
278137001870	2TM domain; Region: 2TM; pfam13239
278137001871	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
278137001872	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
278137001873	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
278137001874	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
278137001875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137001876	Walker A motif; other site
278137001877	ATP binding site [chemical binding]; other site
278137001878	Walker B motif; other site
278137001879	arginine finger; other site
278137001880	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
278137001881	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
278137001882	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
278137001883	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
278137001884	dimer interface [polypeptide binding]; other site
278137001885	putative functional site; other site
278137001886	putative MPT binding site; other site
278137001887	short chain dehydrogenase; Provisional; Region: PRK06197
278137001888	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
278137001889	putative NAD(P) binding site [chemical binding]; other site
278137001890	active site
278137001891	Uncharacterized conserved protein [Function unknown]; Region: COG3402
278137001892	Predicted membrane protein [Function unknown]; Region: COG3428
278137001893	Bacterial PH domain; Region: DUF304; pfam03703
278137001894	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
278137001895	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
278137001896	DNA binding residues [nucleotide binding]
278137001897	dimer interface [polypeptide binding]; other site
278137001898	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
278137001899	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
278137001900	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137001901	active site
278137001902	motif I; other site
278137001903	motif II; other site
278137001904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137001905	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
278137001906	putative hydrophobic ligand binding site [chemical binding]; other site
278137001907	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
278137001908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137001909	ATP binding site [chemical binding]; other site
278137001910	putative Mg++ binding site [ion binding]; other site
278137001911	Cupin domain; Region: Cupin_2; pfam07883
278137001912	short chain dehydrogenase; Provisional; Region: PRK06197
278137001913	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
278137001914	putative NAD(P) binding site [chemical binding]; other site
278137001915	active site
278137001916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137001917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137001918	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
278137001919	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
278137001920	ring oligomerisation interface [polypeptide binding]; other site
278137001921	ATP/Mg binding site [chemical binding]; other site
278137001922	stacking interactions; other site
278137001923	hinge regions; other site
278137001924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137001925	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137001926	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
278137001927	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
278137001928	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
278137001929	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
278137001930	active site
278137001931	putative substrate binding pocket [chemical binding]; other site
278137001932	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137001933	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
278137001934	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137001935	Protein of unknown function (DUF664); Region: DUF664; pfam04978
278137001936	DinB superfamily; Region: DinB_2; pfam12867
278137001937	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
278137001938	active site
278137001939	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137001940	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
278137001941	NAD(P) binding site [chemical binding]; other site
278137001942	catalytic residues [active]
278137001943	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
278137001944	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
278137001945	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
278137001946	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137001947	Integrase core domain; Region: rve; pfam00665
278137001948	Integrase core domain; Region: rve_3; pfam13683
278137001949	SnoaL-like domain; Region: SnoaL_3; pfam13474
278137001950	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137001951	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137001952	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137001953	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
278137001954	putative NAD(P) binding site [chemical binding]; other site
278137001955	catalytic Zn binding site [ion binding]; other site
278137001956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137001957	acetoin reductases; Region: 23BDH; TIGR02415
278137001958	NAD(P) binding site [chemical binding]; other site
278137001959	active site
278137001960	GAF domain; Region: GAF; pfam01590
278137001961	Protein of unknown function (DUF779); Region: DUF779; pfam05610
278137001962	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
278137001963	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
278137001964	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
278137001965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
278137001966	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
278137001967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137001968	dimer interface [polypeptide binding]; other site
278137001969	conserved gate region; other site
278137001970	putative PBP binding loops; other site
278137001971	ABC-ATPase subunit interface; other site
278137001972	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
278137001973	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
278137001974	Walker A/P-loop; other site
278137001975	ATP binding site [chemical binding]; other site
278137001976	Q-loop/lid; other site
278137001977	ABC transporter signature motif; other site
278137001978	Walker B; other site
278137001979	D-loop; other site
278137001980	H-loop/switch region; other site
278137001981	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
278137001982	Walker A/P-loop; other site
278137001983	ATP binding site [chemical binding]; other site
278137001984	ABC transporter; Region: ABC_tran; pfam00005
278137001985	Q-loop/lid; other site
278137001986	ABC transporter signature motif; other site
278137001987	Walker B; other site
278137001988	D-loop; other site
278137001989	H-loop/switch region; other site
278137001990	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
278137001991	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
278137001992	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137001993	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
278137001994	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137001995	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137001996	metal binding site [ion binding]; metal-binding site
278137001997	active site
278137001998	I-site; other site
278137001999	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137002000	Uncharacterized conserved protein [Function unknown]; Region: COG2128
278137002001	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
278137002002	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137002003	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137002004	non-specific DNA binding site [nucleotide binding]; other site
278137002005	salt bridge; other site
278137002006	sequence-specific DNA binding site [nucleotide binding]; other site
278137002007	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
278137002008	Domain of unknown function (DUF955); Region: DUF955; pfam06114
278137002009	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
278137002010	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
278137002011	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137002012	active site 2 [active]
278137002013	active site 1 [active]
278137002014	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137002015	active site 2 [active]
278137002016	isocitrate lyase; Provisional; Region: PRK15063
278137002017	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
278137002018	tetramer interface [polypeptide binding]; other site
278137002019	active site
278137002020	Mg2+/Mn2+ binding site [ion binding]; other site
278137002021	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
278137002022	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
278137002023	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
278137002024	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
278137002025	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002026	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002027	Predicted membrane protein [Function unknown]; Region: COG2733
278137002028	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137002029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137002030	non-specific DNA binding site [nucleotide binding]; other site
278137002031	salt bridge; other site
278137002032	sequence-specific DNA binding site [nucleotide binding]; other site
278137002033	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
278137002034	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
278137002035	deoxyribose-phosphate aldolase; Provisional; Region: PRK00507
278137002036	catalytic residue [active]
278137002037	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
278137002038	Predicted amidohydrolase [General function prediction only]; Region: COG0388
278137002039	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
278137002040	putative active site [active]
278137002041	catalytic triad [active]
278137002042	putative dimer interface [polypeptide binding]; other site
278137002043	agmatinase; Region: agmatinase; TIGR01230
278137002044	Agmatinase-like family; Region: Agmatinase-like; cd09990
278137002045	active site
278137002046	oligomer interface [polypeptide binding]; other site
278137002047	Mn binding site [ion binding]; other site
278137002048	ykkC-yxkD element
278137002049	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
278137002050	Na binding site [ion binding]; other site
278137002051	putative glycosylation site [posttranslational modification]; other site
278137002052	putative glycosylation site [posttranslational modification]; other site
278137002053	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
278137002054	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
278137002055	FAD binding domain; Region: FAD_binding_4; pfam01565
278137002056	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
278137002057	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
278137002058	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
278137002059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137002060	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137002061	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
278137002062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137002063	NAD(P) binding site [chemical binding]; other site
278137002064	active site
278137002065	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
278137002066	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137002067	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
278137002068	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
278137002069	putative ADP-binding pocket [chemical binding]; other site
278137002070	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
278137002071	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137002072	catalytic core [active]
278137002073	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137002074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137002075	dimer interface [polypeptide binding]; other site
278137002076	phosphorylation site [posttranslational modification]
278137002077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137002078	ATP binding site [chemical binding]; other site
278137002079	Mg2+ binding site [ion binding]; other site
278137002080	G-X-G motif; other site
278137002081	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137002082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137002083	active site
278137002084	phosphorylation site [posttranslational modification]
278137002085	intermolecular recognition site; other site
278137002086	dimerization interface [polypeptide binding]; other site
278137002087	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137002088	DNA binding site [nucleotide binding]
278137002089	exopolyphosphatase; Region: exo_poly_only; TIGR03706
278137002090	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
278137002091	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
278137002092	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
278137002093	DNA interaction; other site
278137002094	Metal-binding active site; metal-binding site
278137002095	AP (apurinic/apyrimidinic) site pocket; other site
278137002096	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
278137002097	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
278137002098	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
278137002099	DNA binding domain, excisionase family; Region: excise; TIGR01764
278137002100	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
278137002101	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
278137002102	putative NAD(P) binding site [chemical binding]; other site
278137002103	active site
278137002104	putative substrate binding site [chemical binding]; other site
278137002105	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137002106	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
278137002107	putative acyl-acceptor binding pocket; other site
278137002108	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
278137002109	active site
278137002110	catalytic site [active]
278137002111	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
278137002112	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
278137002113	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137002114	MULE transposase domain; Region: MULE; pfam10551
278137002115	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
278137002116	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
278137002117	tRNA; other site
278137002118	putative tRNA binding site [nucleotide binding]; other site
278137002119	putative NADP binding site [chemical binding]; other site
278137002120	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
278137002121	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
278137002122	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
278137002123	domain interfaces; other site
278137002124	active site
278137002125	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
278137002126	homodimer interface [polypeptide binding]; other site
278137002127	active site
278137002128	SAM binding site [chemical binding]; other site
278137002129	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
278137002130	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
278137002131	active site
278137002132	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
278137002133	dimer interface [polypeptide binding]; other site
278137002134	active site
278137002135	Schiff base residues; other site
278137002136	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
278137002137	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002138	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002139	Cytochrome P450; Region: p450; cl12078
278137002140	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002141	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
278137002142	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
278137002143	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
278137002144	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137002145	inhibitor-cofactor binding pocket; inhibition site
278137002146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137002147	catalytic residue [active]
278137002148	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137002149	catalytic core [active]
278137002150	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
278137002151	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
278137002152	catalytic residues [active]
278137002153	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
278137002154	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
278137002155	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
278137002156	ResB-like family; Region: ResB; pfam05140
278137002157	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
278137002158	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
278137002159	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137002160	P-loop; other site
278137002161	Magnesium ion binding site [ion binding]; other site
278137002162	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137002163	von Willebrand factor type A domain; Region: VWA_2; pfam13519
278137002164	metal ion-dependent adhesion site (MIDAS); other site
278137002165	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
278137002166	Protein of unknown function DUF58; Region: DUF58; pfam01882
278137002167	MoxR-like ATPases [General function prediction only]; Region: COG0714
278137002168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137002169	ATP binding site [chemical binding]; other site
278137002170	Walker A motif; other site
278137002171	Walker B motif; other site
278137002172	arginine finger; other site
278137002173	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
278137002174	UbiA prenyltransferase family; Region: UbiA; pfam01040
278137002175	Homeodomain-like domain; Region: HTH_23; cl17451
278137002176	Winged helix-turn helix; Region: HTH_29; pfam13551
278137002177	Integrase core domain; Region: rve; pfam00665
278137002178	Integrase core domain; Region: rve_3; pfam13683
278137002179	Nitronate monooxygenase; Region: NMO; pfam03060
278137002180	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137002181	FMN binding site [chemical binding]; other site
278137002182	substrate binding site [chemical binding]; other site
278137002183	putative catalytic residue [active]
278137002184	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137002185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137002186	dimer interface [polypeptide binding]; other site
278137002187	phosphorylation site [posttranslational modification]
278137002188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137002189	ATP binding site [chemical binding]; other site
278137002190	Mg2+ binding site [ion binding]; other site
278137002191	G-X-G motif; other site
278137002192	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137002193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137002194	active site
278137002195	phosphorylation site [posttranslational modification]
278137002196	intermolecular recognition site; other site
278137002197	dimerization interface [polypeptide binding]; other site
278137002198	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137002199	DNA binding site [nucleotide binding]
278137002200	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
278137002201	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
278137002202	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137002203	acyl-activating enzyme (AAE) consensus motif; other site
278137002204	AMP binding site [chemical binding]; other site
278137002205	active site
278137002206	CoA binding site [chemical binding]; other site
278137002207	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
278137002208	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
278137002209	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
278137002210	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137002211	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
278137002212	active site
278137002213	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
278137002214	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137002215	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137002216	acyl-activating enzyme (AAE) consensus motif; other site
278137002217	acyl-activating enzyme (AAE) consensus motif; other site
278137002218	putative AMP binding site [chemical binding]; other site
278137002219	putative active site [active]
278137002220	putative CoA binding site [chemical binding]; other site
278137002221	short chain dehydrogenase; Provisional; Region: PRK05866
278137002222	classical (c) SDRs; Region: SDR_c; cd05233
278137002223	NAD(P) binding site [chemical binding]; other site
278137002224	active site
278137002225	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137002226	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
278137002227	substrate binding site [chemical binding]; other site
278137002228	oxyanion hole (OAH) forming residues; other site
278137002229	trimer interface [polypeptide binding]; other site
278137002230	Domain of unknown function (DUF385); Region: DUF385; cl04387
278137002231	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
278137002232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137002233	motif II; other site
278137002234	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
278137002235	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
278137002236	active site
278137002237	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137002238	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
278137002239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
278137002240	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
278137002241	Transcriptional regulators [Transcription]; Region: FadR; COG2186
278137002242	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137002243	DNA-binding site [nucleotide binding]; DNA binding site
278137002244	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
278137002245	acyl-CoA synthetase; Validated; Region: PRK06188
278137002246	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137002247	putative active site [active]
278137002248	putative CoA binding site [chemical binding]; other site
278137002249	putative AMP binding site [chemical binding]; other site
278137002250	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002251	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002252	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002253	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002254	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137002255	Permease; Region: Permease; pfam02405
278137002256	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137002257	Permease; Region: Permease; pfam02405
278137002258	mce related protein; Region: MCE; pfam02470
278137002259	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137002260	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002261	mce related protein; Region: MCE; pfam02470
278137002262	mce related protein; Region: MCE; pfam02470
278137002263	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002264	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002265	mce related protein; Region: MCE; pfam02470
278137002266	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002267	mce related protein; Region: MCE; pfam02470
278137002268	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002269	mce related protein; Region: MCE; pfam02470
278137002270	Mannan-binding protein; Region: MVL; pfam12151
278137002271	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
278137002272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002273	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
278137002274	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137002275	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137002276	acyl-activating enzyme (AAE) consensus motif; other site
278137002277	acyl-activating enzyme (AAE) consensus motif; other site
278137002278	putative AMP binding site [chemical binding]; other site
278137002279	putative active site [active]
278137002280	putative CoA binding site [chemical binding]; other site
278137002281	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
278137002282	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
278137002283	O-succinylbenzoate synthase; Provisional; Region: PRK02901
278137002284	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
278137002285	metal binding site [ion binding]; metal-binding site
278137002286	substrate binding pocket [chemical binding]; other site
278137002287	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
278137002288	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
278137002289	conserved cys residue [active]
278137002290	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137002291	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
278137002292	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
278137002293	conserved cys residue [active]
278137002294	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
278137002295	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
278137002296	putative active site [active]
278137002297	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137002298	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137002299	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
278137002300	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
278137002301	dimer interface [polypeptide binding]; other site
278137002302	tetramer interface [polypeptide binding]; other site
278137002303	PYR/PP interface [polypeptide binding]; other site
278137002304	TPP binding site [chemical binding]; other site
278137002305	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
278137002306	TPP-binding site; other site
278137002307	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
278137002308	Thioredoxin; Region: Thioredoxin_4; cl17273
278137002309	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137002310	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
278137002311	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137002312	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
278137002313	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
278137002314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137002315	S-adenosylmethionine binding site [chemical binding]; other site
278137002316	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137002317	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
278137002318	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
278137002319	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
278137002320	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
278137002321	substrate binding pocket [chemical binding]; other site
278137002322	chain length determination region; other site
278137002323	substrate-Mg2+ binding site; other site
278137002324	catalytic residues [active]
278137002325	aspartate-rich region 1; other site
278137002326	active site lid residues [active]
278137002327	aspartate-rich region 2; other site
278137002328	heat shock protein HtpX; Provisional; Region: PRK03072
278137002329	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
278137002330	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
278137002331	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
278137002332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
278137002333	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
278137002334	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
278137002335	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
278137002336	FAD binding pocket [chemical binding]; other site
278137002337	FAD binding motif [chemical binding]; other site
278137002338	phosphate binding motif [ion binding]; other site
278137002339	beta-alpha-beta structure motif; other site
278137002340	NAD binding pocket [chemical binding]; other site
278137002341	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137002342	catalytic loop [active]
278137002343	iron binding site [ion binding]; other site
278137002344	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
278137002345	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
278137002346	putative di-iron ligands [ion binding]; other site
278137002347	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
278137002348	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
278137002349	PE-PPE domain; Region: PE-PPE; pfam08237
278137002350	short chain dehydrogenase; Validated; Region: PRK06182
278137002351	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
278137002352	NADP binding site [chemical binding]; other site
278137002353	active site
278137002354	steroid binding site; other site
278137002355	Cupin; Region: Cupin_6; pfam12852
278137002356	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137002357	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137002358	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
278137002359	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
278137002360	putative ligand binding site [chemical binding]; other site
278137002361	NAD binding site [chemical binding]; other site
278137002362	catalytic site [active]
278137002363	Domain of unknown function (DUF385); Region: DUF385; cl04387
278137002364	Predicted transcriptional regulators [Transcription]; Region: COG1733
278137002365	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
278137002366	SCP-2 sterol transfer family; Region: SCP2; cl01225
278137002367	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137002368	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137002369	active site
278137002370	ATP binding site [chemical binding]; other site
278137002371	substrate binding site [chemical binding]; other site
278137002372	activation loop (A-loop); other site
278137002373	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137002374	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137002375	substrate binding pocket [chemical binding]; other site
278137002376	membrane-bound complex binding site; other site
278137002377	hinge residues; other site
278137002378	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
278137002379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
278137002380	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137002381	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002382	Cytochrome P450; Region: p450; cl12078
278137002383	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
278137002384	DNA-binding site [nucleotide binding]; DNA binding site
278137002385	RNA-binding motif; other site
278137002386	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
278137002387	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
278137002388	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
278137002389	DNA-binding site [nucleotide binding]; DNA binding site
278137002390	RNA-binding motif; other site
278137002391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137002392	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
278137002393	alanine dehydrogenase; Region: alaDH; TIGR00518
278137002394	N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181
278137002395	putative active site [active]
278137002396	putative ligand binding site [chemical binding]; other site
278137002397	putative NAD(P) binding site [chemical binding]; other site
278137002398	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
278137002399	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
278137002400	putative di-iron ligands [ion binding]; other site
278137002401	GAF domain; Region: GAF; cl17456
278137002402	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
278137002403	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137002404	GAF domain; Region: GAF; cl17456
278137002405	ANTAR domain; Region: ANTAR; pfam03861
278137002406	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
278137002407	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
278137002408	acyl-activating enzyme (AAE) consensus motif; other site
278137002409	active site
278137002410	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
278137002411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137002412	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
278137002413	active site
278137002414	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
278137002415	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
278137002416	putative di-iron ligands [ion binding]; other site
278137002417	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
278137002418	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137002419	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
278137002420	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002422	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137002423	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137002424	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137002425	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137002426	active site
278137002427	ATP binding site [chemical binding]; other site
278137002428	substrate binding site [chemical binding]; other site
278137002429	activation loop (A-loop); other site
278137002430	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
278137002431	Transglycosylase; Region: Transgly; pfam00912
278137002432	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
278137002433	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
278137002434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137002435	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137002436	putative substrate translocation pore; other site
278137002437	Z1 domain; Region: Z1; pfam10593
278137002438	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137002439	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
278137002440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137002441	ATP binding site [chemical binding]; other site
278137002442	Mg2+ binding site [ion binding]; other site
278137002443	G-X-G motif; other site
278137002444	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
278137002445	Protein of unknown function (DUF499); Region: DUF499; pfam04465
278137002446	Uncharacterized conserved protein [Function unknown]; Region: COG1479
278137002447	Protein of unknown function DUF262; Region: DUF262; pfam03235
278137002448	Uncharacterized conserved protein [Function unknown]; Region: COG3472
278137002449	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137002450	MULE transposase domain; Region: MULE; pfam10551
278137002451	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
278137002452	Short C-terminal domain; Region: SHOCT; pfam09851
278137002453	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
278137002454	DEAD-like helicases superfamily; Region: DEXDc; smart00487
278137002455	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
278137002456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
278137002457	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137002458	MULE transposase domain; Region: MULE; pfam10551
278137002459	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137002460	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137002461	active site
278137002462	DNA binding site [nucleotide binding]
278137002463	Int/Topo IB signature motif; other site
278137002464	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
278137002465	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137002466	dimer interface [polypeptide binding]; other site
278137002467	active site
278137002468	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002469	Cytochrome P450; Region: p450; cl12078
278137002470	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137002471	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137002472	active site
278137002473	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137002474	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
278137002475	active site
278137002476	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137002477	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137002478	active site
278137002479	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
278137002480	active site
278137002481	catalytic site [active]
278137002482	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
278137002483	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137002484	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
278137002485	putative active site [active]
278137002486	putative catalytic site [active]
278137002487	lipid-transfer protein; Provisional; Region: PRK07855
278137002488	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137002489	active site
278137002490	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
278137002491	enoyl-CoA hydratase; Region: PLN02864
278137002492	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
278137002493	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
278137002494	dimer interaction site [polypeptide binding]; other site
278137002495	substrate-binding tunnel; other site
278137002496	active site
278137002497	catalytic site [active]
278137002498	substrate binding site [chemical binding]; other site
278137002499	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
278137002500	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
278137002501	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
278137002502	acetaldehyde dehydrogenase; Validated; Region: PRK08300
278137002503	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
278137002504	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
278137002505	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
278137002506	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
278137002507	active site
278137002508	catalytic residues [active]
278137002509	metal binding site [ion binding]; metal-binding site
278137002510	DmpG-like communication domain; Region: DmpG_comm; pfam07836
278137002511	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
278137002512	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002513	Cytochrome P450; Region: p450; cl12078
278137002514	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137002515	putative DNA binding site [nucleotide binding]; other site
278137002516	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137002517	putative Zn2+ binding site [ion binding]; other site
278137002518	short chain dehydrogenase; Provisional; Region: PRK07890
278137002519	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137002520	NAD(P) binding site [chemical binding]; other site
278137002521	active site
278137002522	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
278137002523	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137002524	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
278137002525	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
278137002526	hydrophobic ligand binding site; other site
278137002527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137002528	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
278137002529	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137002530	active site
278137002531	lipid-transfer protein; Provisional; Region: PRK07937
278137002532	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137002533	active site
278137002534	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
278137002535	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137002536	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
278137002537	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137002538	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137002539	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
278137002540	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
278137002541	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002542	Cytochrome P450; Region: p450; cl12078
278137002543	enoyl-CoA hydratase; Provisional; Region: PRK07799
278137002544	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137002545	substrate binding site [chemical binding]; other site
278137002546	oxyanion hole (OAH) forming residues; other site
278137002547	trimer interface [polypeptide binding]; other site
278137002548	acyl-CoA synthetase; Validated; Region: PRK07798
278137002549	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137002550	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
278137002551	acyl-activating enzyme (AAE) consensus motif; other site
278137002552	acyl-activating enzyme (AAE) consensus motif; other site
278137002553	putative AMP binding site [chemical binding]; other site
278137002554	putative active site [active]
278137002555	putative CoA binding site [chemical binding]; other site
278137002556	Nitronate monooxygenase; Region: NMO; pfam03060
278137002557	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137002558	FMN binding site [chemical binding]; other site
278137002559	substrate binding site [chemical binding]; other site
278137002560	putative catalytic residue [active]
278137002561	hypothetical protein; Validated; Region: PRK07586
278137002562	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
278137002563	PYR/PP interface [polypeptide binding]; other site
278137002564	dimer interface [polypeptide binding]; other site
278137002565	TPP binding site [chemical binding]; other site
278137002566	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
278137002567	TPP-binding site [chemical binding]; other site
278137002568	dimer interface [polypeptide binding]; other site
278137002569	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137002570	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
278137002571	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
278137002572	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
278137002573	acyl-CoA synthetase; Provisional; Region: PRK13388
278137002574	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137002575	acyl-activating enzyme (AAE) consensus motif; other site
278137002576	AMP binding site [chemical binding]; other site
278137002577	active site
278137002578	CoA binding site [chemical binding]; other site
278137002579	acyl-CoA synthetase; Validated; Region: PRK07867
278137002580	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137002581	acyl-activating enzyme (AAE) consensus motif; other site
278137002582	AMP binding site [chemical binding]; other site
278137002583	active site
278137002584	CoA binding site [chemical binding]; other site
278137002585	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137002586	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137002587	active site
278137002588	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137002589	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
278137002590	FAD binding site [chemical binding]; other site
278137002591	substrate binding site [chemical binding]; other site
278137002592	catalytic base [active]
278137002593	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
278137002594	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137002595	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
278137002596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137002597	NAD(P) binding site [chemical binding]; other site
278137002598	active site
278137002599	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137002600	Permease; Region: Permease; pfam02405
278137002601	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137002602	Permease; Region: Permease; pfam02405
278137002603	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002604	mce related protein; Region: MCE; pfam02470
278137002605	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137002606	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
278137002607	mce related protein; Region: MCE; pfam02470
278137002608	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002609	mce related protein; Region: MCE; pfam02470
278137002610	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
278137002611	mce related protein; Region: MCE; pfam02470
278137002612	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137002613	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002614	mce related protein; Region: MCE; pfam02470
278137002615	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137002616	mce related protein; Region: MCE; pfam02470
278137002617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137002618	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
278137002619	NAD(P) binding site [chemical binding]; other site
278137002620	active site
278137002621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137002622	NAD(P) binding site [chemical binding]; other site
278137002623	active site
278137002624	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
278137002625	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
278137002626	active site
278137002627	homotetramer interface [polypeptide binding]; other site
278137002628	enoyl-CoA hydratase; Provisional; Region: PRK08290
278137002629	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137002630	substrate binding site [chemical binding]; other site
278137002631	oxyanion hole (OAH) forming residues; other site
278137002632	trimer interface [polypeptide binding]; other site
278137002633	short chain dehydrogenase; Provisional; Region: PRK05875
278137002634	classical (c) SDRs; Region: SDR_c; cd05233
278137002635	NAD(P) binding site [chemical binding]; other site
278137002636	active site
278137002637	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
278137002638	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137002639	catalytic loop [active]
278137002640	iron binding site [ion binding]; other site
278137002641	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
278137002642	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
278137002643	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
278137002644	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
278137002645	putative hydrophobic ligand binding site [chemical binding]; other site
278137002646	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
278137002647	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
278137002648	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
278137002649	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
278137002650	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
278137002651	XdhC Rossmann domain; Region: XdhC_C; pfam13478
278137002652	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
278137002653	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
278137002654	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
278137002655	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137002656	active site
278137002657	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137002658	active site
278137002659	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137002660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137002661	active site
278137002662	phosphorylation site [posttranslational modification]
278137002663	intermolecular recognition site; other site
278137002664	dimerization interface [polypeptide binding]; other site
278137002665	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137002666	DNA binding site [nucleotide binding]
278137002667	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137002668	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
278137002669	dimerization interface [polypeptide binding]; other site
278137002670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137002671	dimer interface [polypeptide binding]; other site
278137002672	phosphorylation site [posttranslational modification]
278137002673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137002674	ATP binding site [chemical binding]; other site
278137002675	Mg2+ binding site [ion binding]; other site
278137002676	G-X-G motif; other site
278137002677	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
278137002678	nucleotide binding site/active site [active]
278137002679	HIT family signature motif; other site
278137002680	catalytic residue [active]
278137002681	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
278137002682	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
278137002683	dimer interface [polypeptide binding]; other site
278137002684	acyl-activating enzyme (AAE) consensus motif; other site
278137002685	putative active site [active]
278137002686	AMP binding site [chemical binding]; other site
278137002687	putative CoA binding site [chemical binding]; other site
278137002688	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137002689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137002690	NAD(P) binding site [chemical binding]; other site
278137002691	active site
278137002692	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002693	Cytochrome P450; Region: p450; cl12078
278137002694	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002696	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137002697	classical (c) SDRs; Region: SDR_c; cd05233
278137002698	NAD(P) binding site [chemical binding]; other site
278137002699	active site
278137002700	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137002701	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137002702	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
278137002703	classical (c) SDRs; Region: SDR_c; cd05233
278137002704	NAD(P) binding site [chemical binding]; other site
278137002705	active site
278137002706	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137002707	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137002708	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137002709	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
278137002710	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
278137002711	NAD binding site [chemical binding]; other site
278137002712	catalytic Zn binding site [ion binding]; other site
278137002713	substrate binding site [chemical binding]; other site
278137002714	structural Zn binding site [ion binding]; other site
278137002715	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
278137002716	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137002717	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002718	Cytochrome P450; Region: p450; cl12078
278137002719	short chain dehydrogenase; Provisional; Region: PRK07775
278137002720	classical (c) SDRs; Region: SDR_c; cd05233
278137002721	NAD(P) binding site [chemical binding]; other site
278137002722	active site
278137002723	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002724	Cytochrome P450; Region: p450; cl12078
278137002725	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
278137002726	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
278137002727	NAD binding site [chemical binding]; other site
278137002728	catalytic residues [active]
278137002729	short chain dehydrogenase; Provisional; Region: PRK07774
278137002730	classical (c) SDRs; Region: SDR_c; cd05233
278137002731	NAD(P) binding site [chemical binding]; other site
278137002732	active site
278137002733	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
278137002734	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
278137002735	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
278137002736	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002737	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002738	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137002739	Cytochrome P450; Region: p450; cl12078
278137002740	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
278137002741	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
278137002742	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
278137002743	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
278137002744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
278137002745	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
278137002746	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
278137002747	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
278137002748	synthetase active site [active]
278137002749	NTP binding site [chemical binding]; other site
278137002750	metal binding site [ion binding]; metal-binding site
278137002751	adenylosuccinate lyase; Region: purB; TIGR00928
278137002752	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
278137002753	tetramer interface [polypeptide binding]; other site
278137002754	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
278137002755	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
278137002756	ATP binding site [chemical binding]; other site
278137002757	active site
278137002758	substrate binding site [chemical binding]; other site
278137002759	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
278137002760	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137002761	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002762	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002763	WHG domain; Region: WHG; pfam13305
278137002764	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
278137002765	catalytic residues [active]
278137002766	dimer interface [polypeptide binding]; other site
278137002767	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
278137002768	Predicted deacetylase [General function prediction only]; Region: COG3233
278137002769	putative active site [active]
278137002770	putative Zn binding site [ion binding]; other site
278137002771	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
278137002772	FAD binding domain; Region: FAD_binding_2; pfam00890
278137002773	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
278137002774	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
278137002775	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
278137002776	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
278137002777	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
278137002778	putative active site [active]
278137002779	catalytic triad [active]
278137002780	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
278137002781	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
278137002782	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
278137002783	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
278137002784	active site
278137002785	metal binding site [ion binding]; metal-binding site
278137002786	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
278137002787	active site
278137002788	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
278137002789	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
278137002790	dimerization interface [polypeptide binding]; other site
278137002791	ATP binding site [chemical binding]; other site
278137002792	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
278137002793	dimerization interface [polypeptide binding]; other site
278137002794	ATP binding site [chemical binding]; other site
278137002795	Predicted membrane protein [Function unknown]; Region: COG4425
278137002796	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
278137002797	CAAX protease self-immunity; Region: Abi; pfam02517
278137002798	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
278137002799	amidophosphoribosyltransferase; Provisional; Region: PRK07847
278137002800	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
278137002801	active site
278137002802	tetramer interface [polypeptide binding]; other site
278137002803	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137002804	active site
278137002805	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
278137002806	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
278137002807	putative NAD(P) binding site [chemical binding]; other site
278137002808	putative active site [active]
278137002809	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
278137002810	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
278137002811	dimerization interface [polypeptide binding]; other site
278137002812	putative ATP binding site [chemical binding]; other site
278137002813	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
278137002814	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
278137002815	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
278137002816	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
278137002817	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
278137002818	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137002819	catalytic residue [active]
278137002820	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002821	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002822	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002823	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002824	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
278137002825	heme-binding site [chemical binding]; other site
278137002826	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137002827	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
278137002828	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
278137002829	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
278137002830	active site residue [active]
278137002831	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
278137002832	active site residue [active]
278137002833	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
278137002834	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
278137002835	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
278137002836	catalytic residues [active]
278137002837	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
278137002838	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137002839	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137002840	DNA binding site [nucleotide binding]
278137002841	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
278137002842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
278137002843	PBP superfamily domain; Region: PBP_like_2; cl17296
278137002844	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
278137002845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137002846	dimer interface [polypeptide binding]; other site
278137002847	conserved gate region; other site
278137002848	putative PBP binding loops; other site
278137002849	ABC-ATPase subunit interface; other site
278137002850	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
278137002851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137002852	dimer interface [polypeptide binding]; other site
278137002853	conserved gate region; other site
278137002854	putative PBP binding loops; other site
278137002855	ABC-ATPase subunit interface; other site
278137002856	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
278137002857	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
278137002858	Walker A/P-loop; other site
278137002859	ATP binding site [chemical binding]; other site
278137002860	Q-loop/lid; other site
278137002861	ABC transporter signature motif; other site
278137002862	Walker B; other site
278137002863	D-loop; other site
278137002864	H-loop/switch region; other site
278137002865	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
278137002866	PhoU domain; Region: PhoU; pfam01895
278137002867	PhoU domain; Region: PhoU; pfam01895
278137002868	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
278137002869	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
278137002870	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
278137002871	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
278137002872	FMN binding site [chemical binding]; other site
278137002873	active site
278137002874	catalytic residues [active]
278137002875	substrate binding site [chemical binding]; other site
278137002876	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
278137002877	homodimer interface [polypeptide binding]; other site
278137002878	putative substrate binding pocket [chemical binding]; other site
278137002879	diiron center [ion binding]; other site
278137002880	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
278137002882	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
278137002883	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137002884	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137002885	active site
278137002886	ATP binding site [chemical binding]; other site
278137002887	substrate binding site [chemical binding]; other site
278137002888	activation loop (A-loop); other site
278137002889	chorismate mutase; Provisional; Region: PRK09269
278137002890	Chorismate mutase type II; Region: CM_2; cl00693
278137002891	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137002892	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002893	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137002894	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
278137002895	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137002896	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
278137002897	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
278137002898	putative hydrophobic ligand binding site [chemical binding]; other site
278137002899	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
278137002900	putative hydrophobic ligand binding site [chemical binding]; other site
278137002901	aminotransferase; Validated; Region: PRK07777
278137002902	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137002903	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137002904	homodimer interface [polypeptide binding]; other site
278137002905	catalytic residue [active]
278137002906	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
278137002907	UreF; Region: UreF; pfam01730
278137002908	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
278137002909	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
278137002910	dimer interface [polypeptide binding]; other site
278137002911	catalytic residues [active]
278137002912	UreD urease accessory protein; Region: UreD; pfam01774
278137002913	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
278137002914	urease subunit alpha; Reviewed; Region: ureC; PRK13308
278137002915	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
278137002916	subunit interactions [polypeptide binding]; other site
278137002917	active site
278137002918	flap region; other site
278137002919	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
278137002920	Urease, gamma subunit; Region: Urease_gamma; pfam00547
278137002921	alpha-gamma subunit interface [polypeptide binding]; other site
278137002922	beta-gamma subunit interface [polypeptide binding]; other site
278137002923	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
278137002924	gamma-beta subunit interface [polypeptide binding]; other site
278137002925	alpha-beta subunit interface [polypeptide binding]; other site
278137002926	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
278137002927	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
278137002928	putative ligand binding site [chemical binding]; other site
278137002929	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137002930	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137002931	DNA binding residues [nucleotide binding]
278137002932	dimerization interface [polypeptide binding]; other site
278137002933	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
278137002934	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
278137002935	FMN binding site [chemical binding]; other site
278137002936	active site
278137002937	substrate binding site [chemical binding]; other site
278137002938	catalytic residue [active]
278137002939	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
278137002940	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137002941	dimer interface [polypeptide binding]; other site
278137002942	active site
278137002943	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
278137002944	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137002945	substrate binding site [chemical binding]; other site
278137002946	oxyanion hole (OAH) forming residues; other site
278137002947	trimer interface [polypeptide binding]; other site
278137002948	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
278137002949	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
278137002950	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
278137002951	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
278137002952	conserved cys residue [active]
278137002953	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137002954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137002955	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
278137002956	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
278137002957	acyl-activating enzyme (AAE) consensus motif; other site
278137002958	AMP binding site [chemical binding]; other site
278137002959	active site
278137002960	CoA binding site [chemical binding]; other site
278137002961	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
278137002962	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137002963	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
278137002964	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
278137002965	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
278137002966	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
278137002967	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137002968	ATP binding site [chemical binding]; other site
278137002969	putative Mg++ binding site [ion binding]; other site
278137002970	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137002971	nucleotide binding region [chemical binding]; other site
278137002972	ATP-binding site [chemical binding]; other site
278137002973	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
278137002974	WYL domain; Region: WYL; pfam13280
278137002975	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
278137002976	trimer interface [polypeptide binding]; other site
278137002977	dimer interface [polypeptide binding]; other site
278137002978	putative active site [active]
278137002979	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
278137002980	MPT binding site; other site
278137002981	trimer interface [polypeptide binding]; other site
278137002982	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
278137002983	MoaE homodimer interface [polypeptide binding]; other site
278137002984	MoaD interaction [polypeptide binding]; other site
278137002985	active site residues [active]
278137002986	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
278137002987	ydaO-yuaA element
278137002988	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
278137002989	MoaE interaction surface [polypeptide binding]; other site
278137002990	MoeB interaction surface [polypeptide binding]; other site
278137002991	thiocarboxylated glycine; other site
278137002992	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
278137002993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137002994	FeS/SAM binding site; other site
278137002995	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
278137002996	hypothetical protein; Provisional; Region: PRK11770
278137002997	Domain of unknown function (DUF307); Region: DUF307; pfam03733
278137002998	Domain of unknown function (DUF307); Region: DUF307; pfam03733
278137002999	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
278137003000	DNA-binding site [nucleotide binding]; DNA binding site
278137003001	RNA-binding motif; other site
278137003002	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
278137003003	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
278137003004	putative dimer interface [polypeptide binding]; other site
278137003005	N-terminal domain interface [polypeptide binding]; other site
278137003006	putative substrate binding pocket (H-site) [chemical binding]; other site
278137003007	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
278137003008	H+ Antiporter protein; Region: 2A0121; TIGR00900
278137003009	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
278137003010	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
278137003011	hydrophobic ligand binding site; other site
278137003012	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
278137003013	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
278137003014	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
278137003015	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
278137003016	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
278137003017	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
278137003018	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137003019	catalytic residue [active]
278137003020	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
278137003021	Ferredoxin [Energy production and conversion]; Region: COG1146
278137003022	4Fe-4S binding domain; Region: Fer4; pfam00037
278137003023	ferredoxin-NADP+ reductase; Region: PLN02852
278137003024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137003025	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
278137003026	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
278137003027	beta-galactosidase; Region: BGL; TIGR03356
278137003028	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137003029	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137003030	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
278137003031	putative dimer interface [polypeptide binding]; other site
278137003032	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137003033	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
278137003034	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
278137003035	citrate synthase 2; Provisional; Region: PRK12350
278137003036	Citrate synthase; Region: Citrate_synt; pfam00285
278137003037	oxalacetate binding site [chemical binding]; other site
278137003038	citrylCoA binding site [chemical binding]; other site
278137003039	coenzyme A binding site [chemical binding]; other site
278137003040	catalytic triad [active]
278137003041	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
278137003042	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
278137003043	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
278137003044	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137003046	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
278137003047	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
278137003048	dimer interface [polypeptide binding]; other site
278137003049	active site
278137003050	citrylCoA binding site [chemical binding]; other site
278137003051	NADH binding [chemical binding]; other site
278137003052	cationic pore residues; other site
278137003053	oxalacetate/citrate binding site [chemical binding]; other site
278137003054	coenzyme A binding site [chemical binding]; other site
278137003055	catalytic triad [active]
278137003056	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137003057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137003058	putative substrate translocation pore; other site
278137003059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137003060	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137003061	MarR family; Region: MarR_2; pfam12802
278137003062	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
278137003063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137003064	MspA; Region: MspA; pfam09203
278137003065	MspA; Region: MspA; pfam09203
278137003066	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137003067	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137003068	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137003069	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
278137003070	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
278137003071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137003072	HAMP domain; Region: HAMP; pfam00672
278137003073	dimerization interface [polypeptide binding]; other site
278137003074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137003075	dimer interface [polypeptide binding]; other site
278137003076	phosphorylation site [posttranslational modification]
278137003077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137003078	ATP binding site [chemical binding]; other site
278137003079	Mg2+ binding site [ion binding]; other site
278137003080	G-X-G motif; other site
278137003081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137003082	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137003083	active site
278137003084	phosphorylation site [posttranslational modification]
278137003085	intermolecular recognition site; other site
278137003086	dimerization interface [polypeptide binding]; other site
278137003087	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137003088	DNA binding site [nucleotide binding]
278137003089	Ion channel; Region: Ion_trans_2; pfam07885
278137003090	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
278137003091	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
278137003092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137003093	Walker A/P-loop; other site
278137003094	ATP binding site [chemical binding]; other site
278137003095	Q-loop/lid; other site
278137003096	ABC transporter signature motif; other site
278137003097	Walker B; other site
278137003098	D-loop; other site
278137003099	H-loop/switch region; other site
278137003100	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
278137003101	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
278137003102	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137003103	Walker A/P-loop; other site
278137003104	ATP binding site [chemical binding]; other site
278137003105	Q-loop/lid; other site
278137003106	ABC transporter signature motif; other site
278137003107	Walker B; other site
278137003108	D-loop; other site
278137003109	H-loop/switch region; other site
278137003110	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
278137003111	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
278137003112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137003113	Walker A/P-loop; other site
278137003114	ATP binding site [chemical binding]; other site
278137003115	Q-loop/lid; other site
278137003116	ABC transporter signature motif; other site
278137003117	Walker B; other site
278137003118	D-loop; other site
278137003119	H-loop/switch region; other site
278137003120	Epoxide hydrolase N terminus; Region: EHN; pfam06441
278137003121	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137003122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137003123	Walker A/P-loop; other site
278137003124	ATP binding site [chemical binding]; other site
278137003125	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
278137003126	Predicted membrane protein [Function unknown]; Region: COG1511
278137003127	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
278137003128	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
278137003129	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
278137003130	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
278137003131	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137003132	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137003133	substrate binding site [chemical binding]; other site
278137003134	oxyanion hole (OAH) forming residues; other site
278137003135	trimer interface [polypeptide binding]; other site
278137003136	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
278137003137	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
278137003138	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
278137003139	Beta-lactamase; Region: Beta-lactamase; pfam00144
278137003140	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
278137003141	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
278137003142	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137003143	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137003144	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
278137003145	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
278137003146	hydrophobic ligand binding site; other site
278137003147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137003148	NADH(P)-binding; Region: NAD_binding_10; pfam13460
278137003149	NAD(P) binding site [chemical binding]; other site
278137003150	active site
278137003151	ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622
278137003152	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137003153	Cytochrome P450; Region: p450; cl12078
278137003154	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137003155	Cytochrome P450; Region: p450; cl12078
278137003156	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
278137003157	active site
278137003158	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137003159	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137003160	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137003161	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137003162	Cytochrome P450; Region: p450; cl12078
278137003163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137003164	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
278137003165	Walker A motif; other site
278137003166	ATP binding site [chemical binding]; other site
278137003167	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
278137003168	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
278137003169	metal ion-dependent adhesion site (MIDAS); other site
278137003170	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003171	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137003172	short chain dehydrogenase; Provisional; Region: PRK07814
278137003173	classical (c) SDRs; Region: SDR_c; cd05233
278137003174	NAD(P) binding site [chemical binding]; other site
278137003175	active site
278137003176	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137003177	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137003178	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
278137003179	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137003180	molybdopterin cofactor binding site; other site
278137003181	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
278137003182	molybdopterin cofactor binding site; other site
278137003183	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137003184	metal binding site [ion binding]; metal-binding site
278137003185	active site
278137003186	I-site; other site
278137003187	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137003188	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
278137003189	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137003190	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137003191	acyl-activating enzyme (AAE) consensus motif; other site
278137003192	acyl-activating enzyme (AAE) consensus motif; other site
278137003193	putative AMP binding site [chemical binding]; other site
278137003194	putative active site [active]
278137003195	putative CoA binding site [chemical binding]; other site
278137003196	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
278137003197	classical (c) SDRs; Region: SDR_c; cd05233
278137003198	NAD(P) binding site [chemical binding]; other site
278137003199	active site
278137003200	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
278137003201	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
278137003202	acyl-activating enzyme (AAE) consensus motif; other site
278137003203	putative AMP binding site [chemical binding]; other site
278137003204	putative active site [active]
278137003205	putative CoA binding site [chemical binding]; other site
278137003206	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
278137003207	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137003208	DNA-binding site [nucleotide binding]; DNA binding site
278137003209	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
278137003210	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
278137003211	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
278137003212	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
278137003213	classical (c) SDRs; Region: SDR_c; cd05233
278137003214	NAD(P) binding site [chemical binding]; other site
278137003215	active site
278137003216	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137003217	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137003218	[2Fe-2S] cluster binding site [ion binding]; other site
278137003219	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
278137003220	putative alpha subunit interface [polypeptide binding]; other site
278137003221	putative active site [active]
278137003222	putative substrate binding site [chemical binding]; other site
278137003223	Fe binding site [ion binding]; other site
278137003224	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137003225	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137003226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137003227	NAD(P) binding site [chemical binding]; other site
278137003228	active site
278137003229	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137003230	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137003231	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
278137003232	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137003233	active site
278137003234	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137003235	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137003236	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137003237	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
278137003238	active site
278137003239	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137003240	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137003241	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137003242	active site
278137003243	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
278137003244	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
278137003245	PYR/PP interface [polypeptide binding]; other site
278137003246	dimer interface [polypeptide binding]; other site
278137003247	TPP binding site [chemical binding]; other site
278137003248	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
278137003249	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
278137003250	TPP-binding site; other site
278137003251	dimer interface [polypeptide binding]; other site
278137003252	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
278137003253	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137003254	NAD binding site [chemical binding]; other site
278137003255	catalytic residues [active]
278137003256	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
278137003257	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
278137003258	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
278137003259	dimer interface [polypeptide binding]; other site
278137003260	active site
278137003261	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
278137003262	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137003263	S-adenosylmethionine binding site [chemical binding]; other site
278137003264	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
278137003265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137003266	S-adenosylmethionine binding site [chemical binding]; other site
278137003267	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
278137003268	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
278137003269	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
278137003270	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
278137003271	putative dimer interface [polypeptide binding]; other site
278137003272	Predicted transcriptional regulators [Transcription]; Region: COG1733
278137003273	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
278137003274	Predicted transcriptional regulators [Transcription]; Region: COG1733
278137003275	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
278137003276	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
278137003277	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
278137003278	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
278137003279	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137003280	active site
278137003281	ANTAR domain; Region: ANTAR; pfam03861
278137003282	Helix-turn-helix domain; Region: HTH_17; cl17695
278137003283	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
278137003284	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
278137003285	nucleotide binding site [chemical binding]; other site
278137003286	polymerase nucleotide-binding site; other site
278137003287	primase nucleotide-binding site [nucleotide binding]; other site
278137003288	DNA-binding residues [nucleotide binding]; DNA binding site
278137003289	Helix-turn-helix domain; Region: HTH_17; pfam12728
278137003290	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
278137003291	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137003292	active site
278137003293	DNA binding site [nucleotide binding]
278137003294	Int/Topo IB signature motif; other site
278137003295	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
278137003296	Subunit I/III interface [polypeptide binding]; other site
278137003297	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
278137003298	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137003299	carboxylate-amine ligase; Provisional; Region: PRK13517
278137003300	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
278137003301	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
278137003302	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137003303	Integrase core domain; Region: rve; pfam00665
278137003304	Anti-sigma-K factor rskA; Region: RskA; pfam10099
278137003305	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
278137003306	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137003307	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137003308	DNA binding residues [nucleotide binding]
278137003309	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
278137003310	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
278137003311	putative active site pocket [active]
278137003312	dimerization interface [polypeptide binding]; other site
278137003313	putative catalytic residue [active]
278137003314	Protein of unknown function (DUF867); Region: DUF867; pfam05908
278137003315	manganese transport protein MntH; Reviewed; Region: PRK00701
278137003316	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
278137003317	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137003318	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
278137003319	short chain dehydrogenase; Provisional; Region: PRK07814
278137003320	classical (c) SDRs; Region: SDR_c; cd05233
278137003321	NAD(P) binding site [chemical binding]; other site
278137003322	active site
278137003323	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
278137003324	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
278137003325	putative DNA binding site [nucleotide binding]; other site
278137003326	putative homodimer interface [polypeptide binding]; other site
278137003327	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
278137003328	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
278137003329	putative substrate binding site [chemical binding]; other site
278137003330	putative ATP binding site [chemical binding]; other site
278137003331	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
278137003332	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
278137003333	nucleotide binding site [chemical binding]; other site
278137003334	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
278137003335	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
278137003336	active site
278137003337	DNA binding site [nucleotide binding]
278137003338	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
278137003339	DNA binding site [nucleotide binding]
278137003340	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137003341	classical (c) SDRs; Region: SDR_c; cd05233
278137003342	NAD(P) binding site [chemical binding]; other site
278137003343	active site
278137003344	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
278137003345	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137003346	NAD(P) binding site [chemical binding]; other site
278137003347	active site
278137003348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
278137003349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137003350	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
278137003351	dimerization interface [polypeptide binding]; other site
278137003352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137003353	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137003354	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137003355	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137003356	active site
278137003357	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
278137003358	RNA/DNA hybrid binding site [nucleotide binding]; other site
278137003359	active site
278137003360	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
278137003361	Domain of unknown function (DUF385); Region: DUF385; pfam04075
278137003362	Domain of unknown function (DUF385); Region: DUF385; pfam04075
278137003363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137003364	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137003365	putative substrate translocation pore; other site
278137003366	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
278137003367	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
278137003368	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
278137003369	nucleotide binding site [chemical binding]; other site
278137003370	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
278137003371	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
278137003372	active site
278137003373	metal binding site [ion binding]; metal-binding site
278137003374	nudix motif; other site
278137003375	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137003376	iron-sulfur cluster [ion binding]; other site
278137003377	[2Fe-2S] cluster binding site [ion binding]; other site
278137003378	Uncharacterized conserved protein [Function unknown]; Region: COG3349
278137003379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137003380	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137003381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137003382	S-adenosylmethionine binding site [chemical binding]; other site
278137003383	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
278137003384	active site lid residues [active]
278137003385	substrate binding pocket [chemical binding]; other site
278137003386	catalytic residues [active]
278137003387	substrate-Mg2+ binding site; other site
278137003388	aspartate-rich region 1; other site
278137003389	aspartate-rich region 2; other site
278137003390	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137003391	phytoene desaturase; Region: crtI_fam; TIGR02734
278137003392	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
278137003393	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
278137003394	substrate binding pocket [chemical binding]; other site
278137003395	chain length determination region; other site
278137003396	substrate-Mg2+ binding site; other site
278137003397	catalytic residues [active]
278137003398	aspartate-rich region 1; other site
278137003399	active site lid residues [active]
278137003400	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
278137003401	aspartate-rich region 2; other site
278137003402	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
278137003403	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137003404	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137003405	Predicted membrane protein [Function unknown]; Region: COG1950
278137003406	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
278137003407	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
278137003408	putative DNA binding site [nucleotide binding]; other site
278137003409	catalytic residue [active]
278137003410	putative H2TH interface [polypeptide binding]; other site
278137003411	putative catalytic residues [active]
278137003412	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
278137003413	short chain dehydrogenase; Provisional; Region: PRK08251
278137003414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137003415	NAD(P) binding site [chemical binding]; other site
278137003416	active site
278137003417	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137003418	Cytochrome P450; Region: p450; cl12078
278137003419	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137003420	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137003421	non-specific DNA binding site [nucleotide binding]; other site
278137003422	salt bridge; other site
278137003423	sequence-specific DNA binding site [nucleotide binding]; other site
278137003424	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
278137003425	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
278137003426	active site
278137003427	dimer interface [polypeptide binding]; other site
278137003428	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
278137003429	dimer interface [polypeptide binding]; other site
278137003430	active site
278137003431	succinic semialdehyde dehydrogenase; Region: PLN02278
278137003432	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
278137003433	tetramerization interface [polypeptide binding]; other site
278137003434	NAD(P) binding site [chemical binding]; other site
278137003435	catalytic residues [active]
278137003436	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137003437	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
278137003438	active site
278137003439	catalytic triad [active]
278137003440	oxyanion hole [active]
278137003441	hypothetical protein; Provisional; Region: PRK07857
278137003442	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
278137003443	Part of AAA domain; Region: AAA_19; pfam13245
278137003444	Family description; Region: UvrD_C_2; pfam13538
278137003445	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
278137003446	Peptidase family M23; Region: Peptidase_M23; pfam01551
278137003447	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
278137003448	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
278137003449	CoA-ligase; Region: Ligase_CoA; pfam00549
278137003450	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
278137003451	CoA binding domain; Region: CoA_binding; smart00881
278137003452	CoA-ligase; Region: Ligase_CoA; pfam00549
278137003453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
278137003454	Walker A motif; other site
278137003455	ATP binding site [chemical binding]; other site
278137003456	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137003457	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
278137003458	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137003459	active site
278137003460	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137003461	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137003462	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
278137003463	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
278137003464	active site
278137003465	cosubstrate binding site; other site
278137003466	substrate binding site [chemical binding]; other site
278137003467	catalytic site [active]
278137003468	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
278137003469	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
278137003470	purine monophosphate binding site [chemical binding]; other site
278137003471	dimer interface [polypeptide binding]; other site
278137003472	putative catalytic residues [active]
278137003473	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
278137003474	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
278137003475	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
278137003476	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
278137003477	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
278137003478	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
278137003479	metal ion-dependent adhesion site (MIDAS); other site
278137003480	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
278137003481	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
278137003482	enoyl-CoA hydratase; Provisional; Region: PRK07827
278137003483	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137003484	substrate binding site [chemical binding]; other site
278137003485	oxyanion hole (OAH) forming residues; other site
278137003486	trimer interface [polypeptide binding]; other site
278137003487	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137003488	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137003489	active site
278137003490	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
278137003491	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
278137003492	ATP-grasp domain; Region: ATP-grasp_4; cl17255
278137003493	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
278137003494	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
278137003495	carboxyltransferase (CT) interaction site; other site
278137003496	biotinylation site [posttranslational modification]; other site
278137003497	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
278137003498	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
278137003499	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137003500	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137003501	active site
278137003502	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
278137003503	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137003504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137003505	active site
278137003506	phosphorylation site [posttranslational modification]
278137003507	intermolecular recognition site; other site
278137003508	dimerization interface [polypeptide binding]; other site
278137003509	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137003510	DNA binding site [nucleotide binding]
278137003511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137003512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
278137003513	dimerization interface [polypeptide binding]; other site
278137003514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137003515	dimer interface [polypeptide binding]; other site
278137003516	phosphorylation site [posttranslational modification]
278137003517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137003518	ATP binding site [chemical binding]; other site
278137003519	Mg2+ binding site [ion binding]; other site
278137003520	G-X-G motif; other site
278137003521	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
278137003522	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
278137003523	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
278137003524	MPT binding site; other site
278137003525	trimer interface [polypeptide binding]; other site
278137003526	MspA; Region: MspA; pfam09203
278137003527	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
278137003528	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
278137003529	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
278137003530	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
278137003531	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137003532	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137003533	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
278137003534	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
278137003535	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
278137003536	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
278137003537	active site
278137003538	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
278137003539	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
278137003540	dimer interface [polypeptide binding]; other site
278137003541	putative functional site; other site
278137003542	putative MPT binding site; other site
278137003543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
278137003544	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
278137003545	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137003546	dimerization interface [polypeptide binding]; other site
278137003547	putative DNA binding site [nucleotide binding]; other site
278137003548	putative Zn2+ binding site [ion binding]; other site
278137003549	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
278137003550	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
278137003551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003552	short chain dehydrogenase; Provisional; Region: PRK12827
278137003553	classical (c) SDRs; Region: SDR_c; cd05233
278137003554	NAD(P) binding site [chemical binding]; other site
278137003555	active site
278137003556	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137003557	classical (c) SDRs; Region: SDR_c; cd05233
278137003558	NAD(P) binding site [chemical binding]; other site
278137003559	active site
278137003560	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
278137003561	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
278137003562	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
278137003563	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137003564	NAD(P) binding site [chemical binding]; other site
278137003565	catalytic residues [active]
278137003566	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137003567	Cytochrome P450; Region: p450; cl12078
278137003568	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137003569	MarR family; Region: MarR; pfam01047
278137003570	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
278137003571	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
278137003572	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
278137003573	Cupin domain; Region: Cupin_2; cl17218
278137003574	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137003575	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137003576	metal binding site [ion binding]; metal-binding site
278137003577	active site
278137003578	I-site; other site
278137003579	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
278137003580	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
278137003581	ligand binding site [chemical binding]; other site
278137003582	flexible hinge region; other site
278137003583	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
278137003584	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
278137003585	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
278137003586	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
278137003587	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
278137003588	shikimate binding site; other site
278137003589	NAD(P) binding site [chemical binding]; other site
278137003590	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
278137003591	PE-PPE domain; Region: PE-PPE; pfam08237
278137003592	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
278137003593	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
278137003594	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
278137003595	DNA binding residues [nucleotide binding]
278137003596	dimer interface [polypeptide binding]; other site
278137003597	[2Fe-2S] cluster binding site [ion binding]; other site
278137003598	arginine deiminase; Provisional; Region: PRK01388
278137003599	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
278137003600	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137003601	Integrase core domain; Region: rve; pfam00665
278137003602	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
278137003603	Predicted methyltransferases [General function prediction only]; Region: COG0313
278137003604	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
278137003605	putative SAM binding site [chemical binding]; other site
278137003606	putative homodimer interface [polypeptide binding]; other site
278137003607	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
278137003608	chorismate binding enzyme; Region: Chorismate_bind; cl10555
278137003609	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
278137003610	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137003611	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137003612	DNA binding residues [nucleotide binding]
278137003613	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137003614	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
278137003615	glutamate dehydrogenase; Provisional; Region: PRK09414
278137003616	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
278137003617	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
278137003618	NAD(P) binding site [chemical binding]; other site
278137003619	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
278137003620	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
278137003621	active site
278137003622	HIGH motif; other site
278137003623	KMSKS motif; other site
278137003624	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
278137003625	tRNA binding surface [nucleotide binding]; other site
278137003626	anticodon binding site; other site
278137003627	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
278137003628	active site
278137003629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
278137003630	Domain of unknown function (DUF348); Region: DUF348; pfam03990
278137003631	Domain of unknown function (DUF348); Region: DUF348; pfam03990
278137003632	Domain of unknown function (DUF348); Region: DUF348; pfam03990
278137003633	G5 domain; Region: G5; pfam07501
278137003634	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
278137003635	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
278137003636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137003637	S-adenosylmethionine binding site [chemical binding]; other site
278137003638	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
278137003639	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
278137003640	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137003641	acyl-activating enzyme (AAE) consensus motif; other site
278137003642	AMP binding site [chemical binding]; other site
278137003643	active site
278137003644	CoA binding site [chemical binding]; other site
278137003645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137003646	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
278137003647	Walker A/P-loop; other site
278137003648	ATP binding site [chemical binding]; other site
278137003649	Q-loop/lid; other site
278137003650	ABC transporter signature motif; other site
278137003651	Walker B; other site
278137003652	D-loop; other site
278137003653	H-loop/switch region; other site
278137003654	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
278137003655	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
278137003656	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
278137003657	putative active site [active]
278137003658	catalytic residue [active]
278137003659	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
278137003660	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
278137003661	5S rRNA interface [nucleotide binding]; other site
278137003662	CTC domain interface [polypeptide binding]; other site
278137003663	L16 interface [polypeptide binding]; other site
278137003664	short chain dehydrogenase; Provisional; Region: PRK06197
278137003665	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
278137003666	putative NAD(P) binding site [chemical binding]; other site
278137003667	active site
278137003668	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
278137003669	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
278137003670	ArsC family; Region: ArsC; pfam03960
278137003671	catalytic residues [active]
278137003672	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
278137003673	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
278137003674	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137003675	active site
278137003676	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
278137003677	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
278137003678	Substrate binding site; other site
278137003679	Mg++ binding site; other site
278137003680	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
278137003681	active site
278137003682	substrate binding site [chemical binding]; other site
278137003683	CoA binding site [chemical binding]; other site
278137003684	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
278137003685	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
278137003686	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
278137003687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137003689	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
278137003690	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
278137003691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137003692	ATP binding site [chemical binding]; other site
278137003693	putative Mg++ binding site [ion binding]; other site
278137003694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137003695	nucleotide binding region [chemical binding]; other site
278137003696	ATP-binding site [chemical binding]; other site
278137003697	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
278137003698	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
278137003699	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
278137003700	homodimer interface [polypeptide binding]; other site
278137003701	metal binding site [ion binding]; metal-binding site
278137003702	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
278137003703	Imelysin; Region: Peptidase_M75; pfam09375
278137003704	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
278137003705	N-acetyl-D-glucosamine binding site [chemical binding]; other site
278137003706	enolase; Provisional; Region: eno; PRK00077
278137003707	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
278137003708	dimer interface [polypeptide binding]; other site
278137003709	metal binding site [ion binding]; metal-binding site
278137003710	substrate binding pocket [chemical binding]; other site
278137003711	Septum formation initiator; Region: DivIC; pfam04977
278137003712	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
278137003713	Uncharacterized conserved protein [Function unknown]; Region: COG1507
278137003714	exopolyphosphatase; Region: exo_poly_only; TIGR03706
278137003715	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
278137003716	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
278137003717	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
278137003718	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137003719	acyl-activating enzyme (AAE) consensus motif; other site
278137003720	AMP binding site [chemical binding]; other site
278137003721	active site
278137003722	CoA binding site [chemical binding]; other site
278137003723	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137003724	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
278137003725	oxidoreductase; Provisional; Region: PRK06128
278137003726	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137003727	NAD(P) binding site [chemical binding]; other site
278137003728	active site
278137003729	hypothetical protein; Provisional; Region: PRK14059
278137003730	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
278137003731	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
278137003732	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
278137003733	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137003734	NAD binding site [chemical binding]; other site
278137003735	catalytic Zn binding site [ion binding]; other site
278137003736	structural Zn binding site [ion binding]; other site
278137003737	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
278137003738	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
278137003739	active site
278137003740	DNA binding site [nucleotide binding]
278137003741	Int/Topo IB signature motif; other site
278137003742	transcription termination factor Rho; Provisional; Region: PRK12678
278137003743	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
278137003744	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
278137003745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137003746	Transposase; Region: HTH_Tnp_1; pfam01527
278137003747	putative transposase OrfB; Reviewed; Region: PHA02517
278137003748	HTH-like domain; Region: HTH_21; pfam13276
278137003749	Integrase core domain; Region: rve; pfam00665
278137003750	Integrase core domain; Region: rve_3; pfam13683
278137003751	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137003752	Transposase; Region: HTH_Tnp_1; pfam01527
278137003753	HTH-like domain; Region: HTH_21; pfam13276
278137003754	Integrase core domain; Region: rve; pfam00665
278137003755	Integrase core domain; Region: rve_3; pfam13683
278137003756	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
278137003757	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
278137003758	metal binding site [ion binding]; metal-binding site
278137003759	putative dimer interface [polypeptide binding]; other site
278137003760	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
278137003761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137003762	non-specific DNA binding site [nucleotide binding]; other site
278137003763	salt bridge; other site
278137003764	sequence-specific DNA binding site [nucleotide binding]; other site
278137003765	Domain of unknown function (DUF955); Region: DUF955; cl01076
278137003766	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
278137003767	MarR family; Region: MarR_2; pfam12802
278137003768	Integrase core domain; Region: rve; pfam00665
278137003769	Integrase core domain; Region: rve_3; cl15866
278137003770	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
278137003771	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137003772	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137003773	active site
278137003774	DNA binding site [nucleotide binding]
278137003775	Int/Topo IB signature motif; other site
278137003776	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137003777	active site
278137003778	DNA binding site [nucleotide binding]
278137003779	Int/Topo IB signature motif; other site
278137003780	Peptidase family M48; Region: Peptidase_M48; cl12018
278137003781	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137003782	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
278137003783	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003784	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137003785	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
278137003786	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
278137003787	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137003788	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137003789	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137003790	CoenzymeA binding site [chemical binding]; other site
278137003791	subunit interaction site [polypeptide binding]; other site
278137003792	PHB binding site; other site
278137003793	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137003794	Cytochrome P450; Region: p450; cl12078
278137003795	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003796	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137003797	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137003798	Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565
278137003799	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137003800	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003801	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137003802	CoenzymeA binding site [chemical binding]; other site
278137003803	subunit interaction site [polypeptide binding]; other site
278137003804	PHB binding site; other site
278137003805	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137003806	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137003807	Helix-turn-helix domain; Region: HTH_17; pfam12728
278137003808	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137003809	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137003810	active site
278137003811	DNA binding site [nucleotide binding]
278137003812	Int/Topo IB signature motif; other site
278137003813	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137003814	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137003815	active site
278137003816	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
278137003817	E-class dimer interface [polypeptide binding]; other site
278137003818	P-class dimer interface [polypeptide binding]; other site
278137003819	active site
278137003820	Cu2+ binding site [ion binding]; other site
278137003821	Zn2+ binding site [ion binding]; other site
278137003822	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
278137003823	Domain of unknown function (DUF385); Region: DUF385; cl04387
278137003824	acyl-CoA synthetase; Validated; Region: PRK07788
278137003825	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137003826	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137003827	acyl-activating enzyme (AAE) consensus motif; other site
278137003828	acyl-activating enzyme (AAE) consensus motif; other site
278137003829	AMP binding site [chemical binding]; other site
278137003830	active site
278137003831	CoA binding site [chemical binding]; other site
278137003832	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
278137003833	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
278137003834	cyanate hydratase; Validated; Region: PRK02866
278137003835	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
278137003836	oligomer interface [polypeptide binding]; other site
278137003837	active site
278137003838	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
278137003839	Spore germination protein; Region: Spore_permease; cl17796
278137003840	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137003841	Ligand Binding Site [chemical binding]; other site
278137003842	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137003843	Ligand Binding Site [chemical binding]; other site
278137003844	Secretory lipase; Region: LIP; pfam03583
278137003845	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137003846	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137003847	classical (c) SDRs; Region: SDR_c; cd05233
278137003848	NAD(P) binding site [chemical binding]; other site
278137003849	active site
278137003850	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
278137003851	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
278137003852	putative active site [active]
278137003853	putative dimer interface [polypeptide binding]; other site
278137003854	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137003855	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137003856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137003857	Coenzyme A binding pocket [chemical binding]; other site
278137003858	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
278137003859	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
278137003860	Cl- selectivity filter; other site
278137003861	Cl- binding residues [ion binding]; other site
278137003862	pore gating glutamate residue; other site
278137003863	dimer interface [polypeptide binding]; other site
278137003864	H+/Cl- coupling transport residue; other site
278137003865	Interferon-induced transmembrane protein; Region: CD225; pfam04505
278137003866	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
278137003867	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137003868	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
278137003869	yybP-ykoY element
278137003870	Predicted membrane protein [Function unknown]; Region: COG2119
278137003871	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
278137003872	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
278137003873	putative transporter; Provisional; Region: PRK10504
278137003874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137003875	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137003876	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137003877	anti sigma factor interaction site; other site
278137003878	regulatory phosphorylation site [posttranslational modification]; other site
278137003879	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137003880	anti sigma factor interaction site; other site
278137003881	regulatory phosphorylation site [posttranslational modification]; other site
278137003882	lipid-transfer protein; Provisional; Region: PRK08256
278137003883	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137003884	active site
278137003885	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137003886	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137003887	active site
278137003888	ATP binding site [chemical binding]; other site
278137003889	substrate binding site [chemical binding]; other site
278137003890	activation loop (A-loop); other site
278137003891	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137003892	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137003893	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
278137003894	hydrophobic ligand binding site; other site
278137003895	Patatin-like phospholipase; Region: Patatin; pfam01734
278137003896	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
278137003897	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
278137003898	active site
278137003899	nucleophile elbow; other site
278137003900	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137003901	dimerization interface [polypeptide binding]; other site
278137003902	putative DNA binding site [nucleotide binding]; other site
278137003903	putative Zn2+ binding site [ion binding]; other site
278137003904	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
278137003905	putative hydrophobic ligand binding site [chemical binding]; other site
278137003906	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
278137003907	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
278137003908	active site residue [active]
278137003909	Predicted membrane protein [Function unknown]; Region: COG4425
278137003910	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
278137003911	enoyl-CoA hydratase; Provisional; Region: PRK05862
278137003912	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137003913	substrate binding site [chemical binding]; other site
278137003914	oxyanion hole (OAH) forming residues; other site
278137003915	trimer interface [polypeptide binding]; other site
278137003916	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
278137003917	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137003918	substrate binding site [chemical binding]; other site
278137003919	oxyanion hole (OAH) forming residues; other site
278137003920	trimer interface [polypeptide binding]; other site
278137003921	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
278137003922	Bax inhibitor 1 like; Region: BaxI_1; cl17691
278137003923	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
278137003924	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
278137003925	ATP-grasp domain; Region: ATP-grasp; pfam02222
278137003926	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
278137003927	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137003928	dimer interface [polypeptide binding]; other site
278137003929	active site
278137003930	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
278137003931	active site
278137003932	catalytic triad [active]
278137003933	oxyanion hole [active]
278137003934	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
278137003935	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137003936	substrate binding pocket [chemical binding]; other site
278137003937	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
278137003938	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
278137003939	dimer interface [polypeptide binding]; other site
278137003940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137003941	catalytic residue [active]
278137003942	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
278137003943	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
278137003944	RDD family; Region: RDD; pfam06271
278137003945	cystathionine gamma-synthase; Provisional; Region: PRK07811
278137003946	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
278137003947	homodimer interface [polypeptide binding]; other site
278137003948	substrate-cofactor binding pocket; other site
278137003949	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137003950	catalytic residue [active]
278137003951	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
278137003952	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
278137003953	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
278137003954	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
278137003955	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
278137003956	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
278137003957	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137003958	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
278137003959	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
278137003960	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
278137003961	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
278137003962	catalytic residue [active]
278137003963	putative FPP diphosphate  binding site; other site
278137003964	putative FPP binding hydrophobic cleft; other site
278137003965	dimer interface [polypeptide binding]; other site
278137003966	putative IPP diphosphate binding site; other site
278137003967	pantothenate kinase; Provisional; Region: PRK05439
278137003968	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
278137003969	ATP-binding site [chemical binding]; other site
278137003970	CoA-binding site [chemical binding]; other site
278137003971	Mg2+-binding site [ion binding]; other site
278137003972	serine hydroxymethyltransferase; Provisional; Region: PRK13580
278137003973	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
278137003974	dimer interface [polypeptide binding]; other site
278137003975	active site
278137003976	glycine-pyridoxal phosphate binding site [chemical binding]; other site
278137003977	folate binding site [chemical binding]; other site
278137003978	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
278137003979	dinuclear metal binding motif [ion binding]; other site
278137003980	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
278137003981	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
278137003982	putative active site [active]
278137003983	PhoH-like protein; Region: PhoH; pfam02562
278137003984	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
278137003985	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
278137003986	fumarate hydratase; Reviewed; Region: fumC; PRK00485
278137003987	Class II fumarases; Region: Fumarase_classII; cd01362
278137003988	active site
278137003989	tetramer interface [polypeptide binding]; other site
278137003990	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
278137003991	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
278137003992	putative active site [active]
278137003993	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
278137003994	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
278137003995	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
278137003996	Domain of unknown function DUF20; Region: UPF0118; pfam01594
278137003997	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137003998	classical (c) SDRs; Region: SDR_c; cd05233
278137003999	NAD(P) binding site [chemical binding]; other site
278137004000	active site
278137004001	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
278137004002	hydrophobic ligand binding site; other site
278137004003	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137004004	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137004005	metal binding site [ion binding]; metal-binding site
278137004006	active site
278137004007	I-site; other site
278137004008	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137004009	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137004010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004011	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
278137004012	NAD(P) binding site [chemical binding]; other site
278137004013	active site
278137004014	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
278137004015	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
278137004016	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
278137004017	generic binding surface II; other site
278137004018	generic binding surface I; other site
278137004019	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
278137004020	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
278137004021	GTP-binding protein YchF; Reviewed; Region: PRK09601
278137004022	YchF GTPase; Region: YchF; cd01900
278137004023	G1 box; other site
278137004024	GTP/Mg2+ binding site [chemical binding]; other site
278137004025	Switch I region; other site
278137004026	G2 box; other site
278137004027	Switch II region; other site
278137004028	G3 box; other site
278137004029	G4 box; other site
278137004030	G5 box; other site
278137004031	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
278137004032	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
278137004033	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
278137004034	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
278137004035	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
278137004036	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
278137004037	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
278137004038	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
278137004039	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137004040	cyclase homology domain; Region: CHD; cd07302
278137004041	nucleotidyl binding site; other site
278137004042	metal binding site [ion binding]; metal-binding site
278137004043	dimer interface [polypeptide binding]; other site
278137004044	Transposase domain (DUF772); Region: DUF772; pfam05598
278137004045	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137004046	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
278137004047	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137004048	hypothetical protein; Provisional; Region: PRK06149
278137004049	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
278137004050	active site
278137004051	ATP binding site [chemical binding]; other site
278137004052	substrate binding site [chemical binding]; other site
278137004053	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137004054	inhibitor-cofactor binding pocket; inhibition site
278137004055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137004056	catalytic residue [active]
278137004057	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137004058	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137004059	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004060	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
278137004061	dimer interface [polypeptide binding]; other site
278137004062	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137004063	Permease; Region: Permease; pfam02405
278137004064	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137004065	Permease; Region: Permease; pfam02405
278137004066	mce related protein; Region: MCE; pfam02470
278137004067	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137004068	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137004069	mce related protein; Region: MCE; pfam02470
278137004070	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137004071	mce related protein; Region: MCE; pfam02470
278137004072	mce related protein; Region: MCE; pfam02470
278137004073	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137004074	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137004075	mce related protein; Region: MCE; pfam02470
278137004076	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137004077	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137004078	mce related protein; Region: MCE; pfam02470
278137004079	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137004080	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004081	WHG domain; Region: WHG; pfam13305
278137004082	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
278137004083	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
278137004084	Predicted membrane protein [Function unknown]; Region: COG2259
278137004085	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
278137004086	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137004087	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137004088	Transcriptional regulators [Transcription]; Region: FadR; COG2186
278137004089	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137004090	FCD domain; Region: FCD; pfam07729
278137004091	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
278137004092	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
278137004093	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
278137004094	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137004095	dimer interface [polypeptide binding]; other site
278137004096	active site
278137004097	enoyl-CoA hydratase; Provisional; Region: PRK08252
278137004098	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137004099	substrate binding site [chemical binding]; other site
278137004100	oxyanion hole (OAH) forming residues; other site
278137004101	trimer interface [polypeptide binding]; other site
278137004102	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137004103	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137004104	active site
278137004105	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137004106	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137004107	Fasciclin domain; Region: Fasciclin; pfam02469
278137004108	oxidoreductase; Provisional; Region: PRK06196
278137004109	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
278137004110	putative NAD(P) binding site [chemical binding]; other site
278137004111	active site
278137004112	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
278137004113	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
278137004114	trimer interface [polypeptide binding]; other site
278137004115	putative metal binding site [ion binding]; other site
278137004116	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004117	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
278137004118	NAD(P) binding site [chemical binding]; other site
278137004119	active site
278137004120	CAAX protease self-immunity; Region: Abi; pfam02517
278137004121	enoyl-CoA hydratase; Provisional; Region: PRK06688
278137004122	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137004123	substrate binding site [chemical binding]; other site
278137004124	oxyanion hole (OAH) forming residues; other site
278137004125	trimer interface [polypeptide binding]; other site
278137004126	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137004127	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137004128	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
278137004129	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
278137004130	NAD binding site [chemical binding]; other site
278137004131	homodimer interface [polypeptide binding]; other site
278137004132	homotetramer interface [polypeptide binding]; other site
278137004133	active site
278137004134	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
278137004135	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137004136	FMN binding site [chemical binding]; other site
278137004137	substrate binding site [chemical binding]; other site
278137004138	putative catalytic residue [active]
278137004139	DoxX; Region: DoxX; pfam07681
278137004140	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137004141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137004142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004143	WHG domain; Region: WHG; pfam13305
278137004144	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137004145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137004146	S-adenosylmethionine binding site [chemical binding]; other site
278137004147	NAD-dependent deacetylase; Provisional; Region: PRK00481
278137004148	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
278137004149	NAD+ binding site [chemical binding]; other site
278137004150	substrate binding site [chemical binding]; other site
278137004151	Zn binding site [ion binding]; other site
278137004152	Predicted transcriptional regulators [Transcription]; Region: COG1725
278137004153	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137004154	DNA-binding site [nucleotide binding]; DNA binding site
278137004155	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137004156	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
278137004157	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
278137004158	Integrase core domain; Region: rve; pfam00665
278137004159	Integrase core domain; Region: rve_3; pfam13683
278137004160	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
278137004161	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
278137004162	Na binding site [ion binding]; other site
278137004163	Transposase domain (DUF772); Region: DUF772; pfam05598
278137004164	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137004165	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
278137004166	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
278137004167	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
278137004168	Na binding site [ion binding]; other site
278137004169	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
278137004170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137004171	active site
278137004172	phosphorylation site [posttranslational modification]
278137004173	intermolecular recognition site; other site
278137004174	dimerization interface [polypeptide binding]; other site
278137004175	LytTr DNA-binding domain; Region: LytTR; smart00850
278137004176	Histidine kinase; Region: His_kinase; pfam06580
278137004177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137004178	ATP binding site [chemical binding]; other site
278137004179	Mg2+ binding site [ion binding]; other site
278137004180	G-X-G motif; other site
278137004181	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
278137004182	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
278137004183	minor groove reading motif; other site
278137004184	helix-hairpin-helix signature motif; other site
278137004185	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
278137004186	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
278137004187	Presynaptic Site I dimer interface [polypeptide binding]; other site
278137004188	catalytic residues [active]
278137004189	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
278137004190	Synaptic Flat tetramer interface [polypeptide binding]; other site
278137004191	Synaptic Site I dimer interface [polypeptide binding]; other site
278137004192	FMN binding site [chemical binding]; other site
278137004193	Nitroreductase family; Region: Nitroreductase; pfam00881
278137004194	dimer interface [polypeptide binding]; other site
278137004195	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
278137004196	aromatic arch; other site
278137004197	DCoH dimer interaction site [polypeptide binding]; other site
278137004198	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
278137004199	DCoH tetramer interaction site [polypeptide binding]; other site
278137004200	substrate binding site [chemical binding]; other site
278137004201	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
278137004202	active site
278137004203	8-oxo-dGMP binding site [chemical binding]; other site
278137004204	nudix motif; other site
278137004205	metal binding site [ion binding]; metal-binding site
278137004206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137004207	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
278137004208	putative substrate translocation pore; other site
278137004209	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
278137004210	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
278137004211	[4Fe-4S] binding site [ion binding]; other site
278137004212	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137004213	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137004214	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137004215	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
278137004216	molybdopterin cofactor binding site; other site
278137004217	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
278137004218	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
278137004219	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
278137004220	Protein of unknown function, DUF488; Region: DUF488; pfam04343
278137004221	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
278137004222	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
278137004223	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
278137004224	G1 box; other site
278137004225	putative GEF interaction site [polypeptide binding]; other site
278137004226	GTP/Mg2+ binding site [chemical binding]; other site
278137004227	Switch I region; other site
278137004228	G2 box; other site
278137004229	G3 box; other site
278137004230	Switch II region; other site
278137004231	G4 box; other site
278137004232	G5 box; other site
278137004233	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
278137004234	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
278137004235	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
278137004236	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
278137004237	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
278137004238	FO synthase; Reviewed; Region: fbiC; PRK09234
278137004239	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137004240	FeS/SAM binding site; other site
278137004241	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137004242	FeS/SAM binding site; other site
278137004243	YceI-like domain; Region: YceI; smart00867
278137004244	Ferredoxin [Energy production and conversion]; Region: COG1146
278137004245	4Fe-4S binding domain; Region: Fer4; pfam00037
278137004246	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
278137004247	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137004248	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137004249	homodimer interface [polypeptide binding]; other site
278137004250	catalytic residue [active]
278137004251	Proline dehydrogenase; Region: Pro_dh; cl03282
278137004252	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
278137004253	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
278137004254	NAD(P) binding site [chemical binding]; other site
278137004255	catalytic residues [active]
278137004256	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
278137004257	dimer interface [polypeptide binding]; other site
278137004258	active site
278137004259	ADP-ribose binding site [chemical binding]; other site
278137004260	nudix motif; other site
278137004261	metal binding site [ion binding]; metal-binding site
278137004262	acyl-CoA synthetase; Validated; Region: PRK07787
278137004263	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137004264	acyl-activating enzyme (AAE) consensus motif; other site
278137004265	AMP binding site [chemical binding]; other site
278137004266	active site
278137004267	CoA binding site [chemical binding]; other site
278137004268	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
278137004269	active site
278137004270	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
278137004271	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
278137004272	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
278137004273	putative trimer interface [polypeptide binding]; other site
278137004274	putative CoA binding site [chemical binding]; other site
278137004275	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
278137004276	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
278137004277	metal binding site [ion binding]; metal-binding site
278137004278	putative dimer interface [polypeptide binding]; other site
278137004279	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
278137004280	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
278137004281	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
278137004282	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
278137004283	AAA domain; Region: AAA_22; pfam13401
278137004284	AAA ATPase domain; Region: AAA_16; pfam13191
278137004285	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
278137004286	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
278137004287	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
278137004288	acyl-activating enzyme (AAE) consensus motif; other site
278137004289	putative AMP binding site [chemical binding]; other site
278137004290	putative active site [active]
278137004291	putative CoA binding site [chemical binding]; other site
278137004292	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
278137004293	dihydropteroate synthase; Region: DHPS; TIGR01496
278137004294	substrate binding pocket [chemical binding]; other site
278137004295	dimer interface [polypeptide binding]; other site
278137004296	inhibitor binding site; inhibition site
278137004297	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
278137004298	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
278137004299	DivIVA domain; Region: DivI1A_domain; TIGR03544
278137004300	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
278137004301	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
278137004302	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
278137004303	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137004304	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137004305	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137004306	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
278137004307	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
278137004308	ligand binding site; other site
278137004309	oligomer interface; other site
278137004310	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
278137004311	dimer interface [polypeptide binding]; other site
278137004312	N-terminal domain interface [polypeptide binding]; other site
278137004313	sulfate 1 binding site; other site
278137004314	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
278137004315	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
278137004316	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
278137004317	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
278137004318	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
278137004319	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
278137004320	Walker A/P-loop; other site
278137004321	ATP binding site [chemical binding]; other site
278137004322	Q-loop/lid; other site
278137004323	ABC transporter signature motif; other site
278137004324	Walker B; other site
278137004325	D-loop; other site
278137004326	H-loop/switch region; other site
278137004327	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137004328	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004329	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
278137004330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137004331	S-adenosylmethionine binding site [chemical binding]; other site
278137004332	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
278137004333	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137004334	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137004335	DNA binding residues [nucleotide binding]
278137004336	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
278137004337	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
278137004338	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
278137004339	protein binding site [polypeptide binding]; other site
278137004340	sec-independent translocase; Provisional; Region: PRK03100
278137004341	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
278137004342	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
278137004343	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
278137004344	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
278137004345	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
278137004346	N-acetyl-D-glucosamine binding site [chemical binding]; other site
278137004347	catalytic residue [active]
278137004348	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
278137004349	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
278137004350	MgtE intracellular N domain; Region: MgtE_N; smart00924
278137004351	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
278137004352	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
278137004353	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
278137004354	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
278137004355	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
278137004356	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
278137004357	oligomer interface [polypeptide binding]; other site
278137004358	metal binding site [ion binding]; metal-binding site
278137004359	metal binding site [ion binding]; metal-binding site
278137004360	putative Cl binding site [ion binding]; other site
278137004361	basic sphincter; other site
278137004362	hydrophobic gate; other site
278137004363	periplasmic entrance; other site
278137004364	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
278137004365	Malic enzyme, N-terminal domain; Region: malic; pfam00390
278137004366	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
278137004367	putative NAD(P) binding site [chemical binding]; other site
278137004368	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
278137004369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004370	short chain dehydrogenase; Provisional; Region: PRK08267
278137004371	NAD(P) binding site [chemical binding]; other site
278137004372	active site
278137004373	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137004374	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
278137004375	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
278137004376	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
278137004377	TPP-binding site [chemical binding]; other site
278137004378	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
278137004379	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
278137004380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137004381	putative substrate translocation pore; other site
278137004382	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
278137004383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137004384	putative substrate translocation pore; other site
278137004385	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137004386	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
278137004387	RNase_H superfamily; Region: RNase_H_2; pfam13482
278137004388	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
278137004389	AAA domain; Region: AAA_12; pfam13087
278137004390	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
278137004391	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
278137004392	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
278137004393	ATP binding site [chemical binding]; other site
278137004394	Mg++ binding site [ion binding]; other site
278137004395	motif III; other site
278137004396	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137004397	nucleotide binding region [chemical binding]; other site
278137004398	ATP-binding site [chemical binding]; other site
278137004399	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
278137004400	putative RNA binding site [nucleotide binding]; other site
278137004401	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137004402	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
278137004403	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
278137004404	FAD binding pocket [chemical binding]; other site
278137004405	FAD binding motif [chemical binding]; other site
278137004406	phosphate binding motif [ion binding]; other site
278137004407	NAD binding pocket [chemical binding]; other site
278137004408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137004409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004410	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137004411	Cytochrome P450; Region: p450; cl12078
278137004412	FAD binding domain; Region: FAD_binding_4; pfam01565
278137004413	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
278137004414	Predicted transcriptional regulators [Transcription]; Region: COG1733
278137004415	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
278137004416	H+ Antiporter protein; Region: 2A0121; TIGR00900
278137004417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137004418	PknH-like extracellular domain; Region: PknH_C; pfam14032
278137004419	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
278137004420	Fe-S cluster binding site [ion binding]; other site
278137004421	DNA binding site [nucleotide binding]
278137004422	active site
278137004423	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
278137004424	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137004425	Domain of unknown function (DUF385); Region: DUF385; pfam04075
278137004426	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
278137004427	HIT family signature motif; other site
278137004428	catalytic residue [active]
278137004429	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
278137004430	putative dimer interface [polypeptide binding]; other site
278137004431	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137004432	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137004433	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
278137004434	putative active site [active]
278137004435	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137004436	cyclase homology domain; Region: CHD; cd07302
278137004437	nucleotidyl binding site; other site
278137004438	metal binding site [ion binding]; metal-binding site
278137004439	dimer interface [polypeptide binding]; other site
278137004440	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
278137004441	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
278137004442	metal-binding site [ion binding]
278137004443	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137004444	Domain of unknown function (DUF305); Region: DUF305; pfam03713
278137004445	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
278137004446	putative active site [active]
278137004447	dimerization interface [polypeptide binding]; other site
278137004448	putative tRNAtyr binding site [nucleotide binding]; other site
278137004449	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
278137004450	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
278137004451	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
278137004452	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137004453	molybdopterin cofactor binding site; other site
278137004454	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
278137004455	molybdopterin cofactor binding site; other site
278137004456	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
278137004457	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
278137004458	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
278137004459	Walker A/P-loop; other site
278137004460	ATP binding site [chemical binding]; other site
278137004461	Q-loop/lid; other site
278137004462	ABC transporter signature motif; other site
278137004463	Walker B; other site
278137004464	D-loop; other site
278137004465	H-loop/switch region; other site
278137004466	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
278137004467	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
278137004468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137004469	Walker A/P-loop; other site
278137004470	ATP binding site [chemical binding]; other site
278137004471	Q-loop/lid; other site
278137004472	ABC transporter signature motif; other site
278137004473	Walker B; other site
278137004474	D-loop; other site
278137004475	H-loop/switch region; other site
278137004476	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
278137004477	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
278137004478	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137004479	catalytic core [active]
278137004480	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
278137004481	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
278137004482	active site
278137004483	metal binding site [ion binding]; metal-binding site
278137004484	DNA binding site [nucleotide binding]
278137004485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137004486	Walker A/P-loop; other site
278137004487	ATP binding site [chemical binding]; other site
278137004488	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137004489	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137004490	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
278137004491	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
278137004492	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
278137004493	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
278137004494	Walker A/P-loop; other site
278137004495	ATP binding site [chemical binding]; other site
278137004496	Q-loop/lid; other site
278137004497	ABC transporter signature motif; other site
278137004498	Walker B; other site
278137004499	D-loop; other site
278137004500	H-loop/switch region; other site
278137004501	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
278137004502	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
278137004503	Walker A/P-loop; other site
278137004504	ATP binding site [chemical binding]; other site
278137004505	Q-loop/lid; other site
278137004506	ABC transporter signature motif; other site
278137004507	Walker B; other site
278137004508	D-loop; other site
278137004509	H-loop/switch region; other site
278137004510	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
278137004511	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
278137004512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137004513	dimer interface [polypeptide binding]; other site
278137004514	conserved gate region; other site
278137004515	putative PBP binding loops; other site
278137004516	ABC-ATPase subunit interface; other site
278137004517	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
278137004518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137004519	dimer interface [polypeptide binding]; other site
278137004520	conserved gate region; other site
278137004521	putative PBP binding loops; other site
278137004522	ABC-ATPase subunit interface; other site
278137004523	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137004524	MULE transposase domain; Region: MULE; pfam10551
278137004525	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137004526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137004527	active site
278137004528	phosphorylation site [posttranslational modification]
278137004529	intermolecular recognition site; other site
278137004530	dimerization interface [polypeptide binding]; other site
278137004531	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137004532	DNA binding site [nucleotide binding]
278137004533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137004534	HAMP domain; Region: HAMP; pfam00672
278137004535	dimerization interface [polypeptide binding]; other site
278137004536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137004537	dimer interface [polypeptide binding]; other site
278137004538	phosphorylation site [posttranslational modification]
278137004539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137004540	ATP binding site [chemical binding]; other site
278137004541	Mg2+ binding site [ion binding]; other site
278137004542	G-X-G motif; other site
278137004543	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
278137004544	active site
278137004545	GtrA-like protein; Region: GtrA; pfam04138
278137004546	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
278137004547	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
278137004548	active site clefts [active]
278137004549	zinc binding site [ion binding]; other site
278137004550	dimer interface [polypeptide binding]; other site
278137004551	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
278137004552	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
278137004553	Active Sites [active]
278137004554	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
278137004555	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
278137004556	CysD dimerization site [polypeptide binding]; other site
278137004557	G1 box; other site
278137004558	putative GEF interaction site [polypeptide binding]; other site
278137004559	GTP/Mg2+ binding site [chemical binding]; other site
278137004560	Switch I region; other site
278137004561	G2 box; other site
278137004562	G3 box; other site
278137004563	Switch II region; other site
278137004564	G4 box; other site
278137004565	G5 box; other site
278137004566	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
278137004567	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
278137004568	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
278137004569	ligand-binding site [chemical binding]; other site
278137004570	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
278137004571	active site
278137004572	Isochorismatase family; Region: Isochorismatase; pfam00857
278137004573	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
278137004574	catalytic triad [active]
278137004575	conserved cis-peptide bond; other site
278137004576	Rrf2 family protein; Region: rrf2_super; TIGR00738
278137004577	Transcriptional regulator; Region: Rrf2; pfam02082
278137004578	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137004579	Nitronate monooxygenase; Region: NMO; pfam03060
278137004580	FMN binding site [chemical binding]; other site
278137004581	substrate binding site [chemical binding]; other site
278137004582	putative catalytic residue [active]
278137004583	probable polyamine oxidase; Region: PLN02268
278137004584	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137004585	hydroxyglutarate oxidase; Provisional; Region: PRK11728
278137004586	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137004587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137004588	active site
278137004589	phosphorylation site [posttranslational modification]
278137004590	intermolecular recognition site; other site
278137004591	dimerization interface [polypeptide binding]; other site
278137004592	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137004593	DNA binding residues [nucleotide binding]
278137004594	dimerization interface [polypeptide binding]; other site
278137004595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
278137004596	Histidine kinase; Region: HisKA_3; pfam07730
278137004597	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
278137004598	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
278137004599	gating phenylalanine in ion channel; other site
278137004600	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
278137004601	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
278137004602	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
278137004603	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137004604	active site
278137004605	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
278137004606	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137004607	active site
278137004608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004609	NAD(P) binding site [chemical binding]; other site
278137004610	active site
278137004611	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
278137004612	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
278137004613	N-acetyl-D-glucosamine binding site [chemical binding]; other site
278137004614	catalytic residue [active]
278137004615	MspA; Region: MspA; pfam09203
278137004616	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
278137004617	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
278137004618	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
278137004619	active site
278137004620	HIGH motif; other site
278137004621	KMSK motif region; other site
278137004622	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
278137004623	tRNA binding surface [nucleotide binding]; other site
278137004624	anticodon binding site; other site
278137004625	diaminopimelate decarboxylase; Region: lysA; TIGR01048
278137004626	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
278137004627	active site
278137004628	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
278137004629	substrate binding site [chemical binding]; other site
278137004630	catalytic residues [active]
278137004631	dimer interface [polypeptide binding]; other site
278137004632	homoserine dehydrogenase; Provisional; Region: PRK06349
278137004633	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
278137004634	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
278137004635	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
278137004636	threonine synthase; Reviewed; Region: PRK06721
278137004637	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
278137004638	homodimer interface [polypeptide binding]; other site
278137004639	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137004640	catalytic residue [active]
278137004641	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
278137004642	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
278137004643	transcription termination factor Rho; Provisional; Region: PRK12608
278137004644	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
278137004645	RNA binding site [nucleotide binding]; other site
278137004646	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
278137004647	multimer interface [polypeptide binding]; other site
278137004648	Walker A motif; other site
278137004649	ATP binding site [chemical binding]; other site
278137004650	Walker B motif; other site
278137004651	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137004652	MarR family; Region: MarR; pfam01047
278137004653	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
278137004654	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
278137004655	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137004656	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004657	acyl-CoA synthetase; Provisional; Region: PRK13388
278137004658	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137004659	acyl-activating enzyme (AAE) consensus motif; other site
278137004660	AMP binding site [chemical binding]; other site
278137004661	active site
278137004662	CoA binding site [chemical binding]; other site
278137004663	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
278137004664	peptide chain release factor 1; Validated; Region: prfA; PRK00591
278137004665	This domain is found in peptide chain release factors; Region: PCRF; smart00937
278137004666	RF-1 domain; Region: RF-1; pfam00472
278137004667	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
278137004668	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137004669	S-adenosylmethionine binding site [chemical binding]; other site
278137004670	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
278137004671	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
278137004672	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
278137004673	Mg++ binding site [ion binding]; other site
278137004674	putative catalytic motif [active]
278137004675	substrate binding site [chemical binding]; other site
278137004676	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
278137004677	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
278137004678	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
278137004679	ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118
278137004680	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
278137004681	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
278137004682	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
278137004683	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
278137004684	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
278137004685	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
278137004686	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
278137004687	beta subunit interaction interface [polypeptide binding]; other site
278137004688	Walker A motif; other site
278137004689	ATP binding site [chemical binding]; other site
278137004690	Walker B motif; other site
278137004691	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
278137004692	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
278137004693	core domain interface [polypeptide binding]; other site
278137004694	delta subunit interface [polypeptide binding]; other site
278137004695	epsilon subunit interface [polypeptide binding]; other site
278137004696	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
278137004697	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
278137004698	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
278137004699	alpha subunit interaction interface [polypeptide binding]; other site
278137004700	Walker A motif; other site
278137004701	ATP binding site [chemical binding]; other site
278137004702	Walker B motif; other site
278137004703	inhibitor binding site; inhibition site
278137004704	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
278137004705	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
278137004706	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
278137004707	gamma subunit interface [polypeptide binding]; other site
278137004708	epsilon subunit interface [polypeptide binding]; other site
278137004709	LBP interface [polypeptide binding]; other site
278137004710	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
278137004711	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
278137004712	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
278137004713	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
278137004714	hinge; other site
278137004715	active site
278137004716	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
278137004717	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
278137004718	DNA binding site [nucleotide binding]
278137004719	active site
278137004720	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
278137004721	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
278137004722	AlkA N-terminal domain; Region: AlkA_N; pfam06029
278137004723	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
278137004724	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
278137004725	minor groove reading motif; other site
278137004726	helix-hairpin-helix signature motif; other site
278137004727	substrate binding pocket [chemical binding]; other site
278137004728	active site
278137004729	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004730	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
278137004731	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137004732	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137004733	[2Fe-2S] cluster binding site [ion binding]; other site
278137004734	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
278137004735	putative alpha subunit interface [polypeptide binding]; other site
278137004736	putative active site [active]
278137004737	putative substrate binding site [chemical binding]; other site
278137004738	Fe binding site [ion binding]; other site
278137004739	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137004740	Uncharacterized conserved protein [Function unknown]; Region: COG2128
278137004741	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
278137004742	glutaminase A; Region: Gln_ase; TIGR03814
278137004743	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
278137004744	Transcriptional regulator [Transcription]; Region: LysR; COG0583
278137004745	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137004746	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
278137004747	dimerization interface [polypeptide binding]; other site
278137004748	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137004749	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137004750	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137004751	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137004752	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137004753	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137004754	active site
278137004755	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137004756	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137004757	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137004758	active site
278137004759	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
278137004760	dimerization interface [polypeptide binding]; other site
278137004761	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137004762	cyclase homology domain; Region: CHD; cd07302
278137004763	nucleotidyl binding site; other site
278137004764	metal binding site [ion binding]; metal-binding site
278137004765	dimer interface [polypeptide binding]; other site
278137004766	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
278137004767	hypothetical protein; Provisional; Region: PRK03298
278137004768	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
278137004769	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137004770	dimer interface [polypeptide binding]; other site
278137004771	substrate binding site [chemical binding]; other site
278137004772	metal binding site [ion binding]; metal-binding site
278137004773	putative acyltransferase; Provisional; Region: PRK05790
278137004774	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137004775	dimer interface [polypeptide binding]; other site
278137004776	active site
278137004777	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
278137004778	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
278137004779	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
278137004780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
278137004781	glycogen branching enzyme; Provisional; Region: PRK05402
278137004782	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
278137004783	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
278137004784	active site
278137004785	catalytic site [active]
278137004786	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
278137004787	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
278137004788	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
278137004789	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
278137004790	active site
278137004791	homodimer interface [polypeptide binding]; other site
278137004792	catalytic site [active]
278137004793	acceptor binding site [chemical binding]; other site
278137004794	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
278137004795	putative homodimer interface [polypeptide binding]; other site
278137004796	putative active site pocket [active]
278137004797	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
278137004798	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
278137004799	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
278137004800	DEAD/DEAH box helicase; Region: DEAD; pfam00270
278137004801	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
278137004802	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
278137004803	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
278137004804	active site
278137004805	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
278137004806	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
278137004807	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
278137004808	putative active site pocket [active]
278137004809	cleavage site
278137004810	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
278137004811	MPN+ (JAMM) motif; other site
278137004812	Zinc-binding site [ion binding]; other site
278137004813	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
278137004814	MoaE interaction surface [polypeptide binding]; other site
278137004815	MoeB interaction surface [polypeptide binding]; other site
278137004816	thiocarboxylated glycine; other site
278137004817	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
278137004818	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
278137004819	dimer interface [polypeptide binding]; other site
278137004820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137004821	catalytic residue [active]
278137004822	Rhomboid family; Region: Rhomboid; cl11446
278137004823	glutamate racemase; Provisional; Region: PRK00865
278137004824	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
278137004825	ribonuclease PH; Reviewed; Region: rph; PRK00173
278137004826	Ribonuclease PH; Region: RNase_PH_bact; cd11362
278137004827	hexamer interface [polypeptide binding]; other site
278137004828	active site
278137004829	Acyltransferase family; Region: Acyl_transf_3; pfam01757
278137004830	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
278137004831	Glucitol operon activator protein (GutM); Region: GutM; cl01890
278137004832	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137004833	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137004834	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
278137004835	Cupin domain; Region: Cupin_2; cl17218
278137004836	Helix-turn-helix domain; Region: HTH_18; pfam12833
278137004837	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137004838	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137004839	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
278137004840	Sulfatase; Region: Sulfatase; pfam00884
278137004841	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
278137004842	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137004843	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004844	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
278137004845	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
278137004846	putative NADP binding site [chemical binding]; other site
278137004847	putative substrate binding site [chemical binding]; other site
278137004848	active site
278137004849	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137004850	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137004851	active site
278137004852	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137004853	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137004854	active site
278137004855	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137004856	active site
278137004857	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
278137004858	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137004859	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
278137004860	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
278137004861	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004862	NAD(P) binding site [chemical binding]; other site
278137004863	active site
278137004864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137004865	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137004866	putative substrate translocation pore; other site
278137004867	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
278137004868	dimerization interface [polypeptide binding]; other site
278137004869	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137004870	cyclase homology domain; Region: CHD; cd07302
278137004871	nucleotidyl binding site; other site
278137004872	metal binding site [ion binding]; metal-binding site
278137004873	dimer interface [polypeptide binding]; other site
278137004874	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137004875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137004876	putative substrate translocation pore; other site
278137004877	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
278137004878	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137004879	acyl-activating enzyme (AAE) consensus motif; other site
278137004880	putative AMP binding site [chemical binding]; other site
278137004881	putative active site [active]
278137004882	putative CoA binding site [chemical binding]; other site
278137004883	short chain dehydrogenase; Provisional; Region: PRK08278
278137004884	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004885	NAD(P) binding site [chemical binding]; other site
278137004886	active site
278137004887	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
278137004888	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
278137004889	B12 binding site [chemical binding]; other site
278137004890	cobalt ligand [ion binding]; other site
278137004891	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
278137004892	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137004893	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137004894	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137004895	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137004896	catalytic loop [active]
278137004897	iron binding site [ion binding]; other site
278137004898	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
278137004899	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137004900	acyl-activating enzyme (AAE) consensus motif; other site
278137004901	AMP binding site [chemical binding]; other site
278137004902	active site
278137004903	CoA binding site [chemical binding]; other site
278137004904	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137004905	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137004906	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137004907	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137004908	active site
278137004909	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137004910	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137004911	substrate binding site [chemical binding]; other site
278137004912	oxyanion hole (OAH) forming residues; other site
278137004913	trimer interface [polypeptide binding]; other site
278137004914	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
278137004915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004916	NAD(P) binding site [chemical binding]; other site
278137004917	active site
278137004918	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
278137004919	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
278137004920	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
278137004921	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137004922	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
278137004923	Bacterial transcriptional regulator; Region: IclR; pfam01614
278137004924	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137004925	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137004926	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
278137004927	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
278137004928	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
278137004929	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365
278137004930	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
278137004931	putative active site [active]
278137004932	Fe(II) binding site [ion binding]; other site
278137004933	putative dimer interface [polypeptide binding]; other site
278137004934	putative tetramer interface [polypeptide binding]; other site
278137004935	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
278137004936	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
278137004937	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
278137004938	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
278137004939	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
278137004940	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004941	NAD(P) binding site [chemical binding]; other site
278137004942	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
278137004943	active site
278137004944	Putative cyclase; Region: Cyclase; pfam04199
278137004945	Predicted flavoprotein [General function prediction only]; Region: COG0431
278137004946	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
278137004947	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137004948	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137004949	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
278137004950	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004951	NAD(P) binding site [chemical binding]; other site
278137004952	active site
278137004953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137004954	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
278137004955	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137004956	Cytochrome P450; Region: p450; cl12078
278137004957	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137004958	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137004959	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
278137004960	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
278137004961	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
278137004962	active site
278137004963	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
278137004964	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
278137004965	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
278137004966	active site
278137004967	enoyl-CoA hydratase; Provisional; Region: PRK12478
278137004968	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137004969	substrate binding site [chemical binding]; other site
278137004970	oxyanion hole (OAH) forming residues; other site
278137004971	trimer interface [polypeptide binding]; other site
278137004972	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137004973	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137004974	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137004975	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137004976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004977	classical (c) SDRs; Region: SDR_c; cd05233
278137004978	NAD(P) binding site [chemical binding]; other site
278137004979	active site
278137004980	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
278137004981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137004982	active site
278137004983	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137004984	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
278137004985	putative acyl-acceptor binding pocket; other site
278137004986	acyl-CoA synthetase; Provisional; Region: PRK13382
278137004987	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137004988	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137004989	acyl-activating enzyme (AAE) consensus motif; other site
278137004990	AMP binding site [chemical binding]; other site
278137004991	active site
278137004992	CoA binding site [chemical binding]; other site
278137004993	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137004994	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137004995	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
278137004996	Ecdysteroid kinase; Region: EcKinase; cl17738
278137004997	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137004998	classical (c) SDRs; Region: SDR_c; cd05233
278137004999	NAD(P) binding site [chemical binding]; other site
278137005000	active site
278137005001	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137005002	Cytochrome P450; Region: p450; cl12078
278137005003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005005	enoyl-CoA hydratase; Provisional; Region: PRK08290
278137005006	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137005007	substrate binding site [chemical binding]; other site
278137005008	oxyanion hole (OAH) forming residues; other site
278137005009	trimer interface [polypeptide binding]; other site
278137005010	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005011	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005012	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005014	active site
278137005015	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137005016	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137005017	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
278137005018	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
278137005019	active site
278137005020	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137005021	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137005022	[2Fe-2S] cluster binding site [ion binding]; other site
278137005023	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
278137005024	alpha subunit interface [polypeptide binding]; other site
278137005025	active site
278137005026	substrate binding site [chemical binding]; other site
278137005027	Fe binding site [ion binding]; other site
278137005028	Uncharacterized conserved protein [Function unknown]; Region: COG2128
278137005029	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
278137005030	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137005031	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005032	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005033	active site
278137005034	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137005035	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137005036	enoyl-CoA hydratase; Provisional; Region: PRK06688
278137005037	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137005038	substrate binding site [chemical binding]; other site
278137005039	oxyanion hole (OAH) forming residues; other site
278137005040	trimer interface [polypeptide binding]; other site
278137005041	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
278137005042	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137005043	dimer interface [polypeptide binding]; other site
278137005044	active site
278137005045	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005046	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005047	active site
278137005048	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005050	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
278137005051	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
278137005052	NAD(P) binding site [chemical binding]; other site
278137005053	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
278137005054	putative active site [active]
278137005055	putative substrate binding site [chemical binding]; other site
278137005056	ATP binding site [chemical binding]; other site
278137005057	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005058	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005059	active site
278137005060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005062	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
278137005063	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
278137005064	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
278137005065	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137005066	NAD(P) binding site [chemical binding]; other site
278137005067	active site
278137005068	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
278137005069	metal ion-dependent adhesion site (MIDAS); other site
278137005070	MoxR-like ATPases [General function prediction only]; Region: COG0714
278137005071	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137005072	Walker A motif; other site
278137005073	ATP binding site [chemical binding]; other site
278137005074	Walker B motif; other site
278137005075	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
278137005076	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005077	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005079	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137005080	classical (c) SDRs; Region: SDR_c; cd05233
278137005081	NAD(P) binding site [chemical binding]; other site
278137005082	active site
278137005083	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137005084	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137005085	[2Fe-2S] cluster binding site [ion binding]; other site
278137005086	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
278137005087	alpha subunit interface [polypeptide binding]; other site
278137005088	active site
278137005089	substrate binding site [chemical binding]; other site
278137005090	Fe binding site [ion binding]; other site
278137005091	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
278137005092	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
278137005093	active site
278137005094	MarR family; Region: MarR_2; pfam12802
278137005095	MarR family; Region: MarR_2; cl17246
278137005096	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
278137005097	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
278137005098	FAD binding pocket [chemical binding]; other site
278137005099	FAD binding motif [chemical binding]; other site
278137005100	phosphate binding motif [ion binding]; other site
278137005101	beta-alpha-beta structure motif; other site
278137005102	NAD(p) ribose binding residues [chemical binding]; other site
278137005103	NAD binding pocket [chemical binding]; other site
278137005104	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
278137005105	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137005106	catalytic loop [active]
278137005107	iron binding site [ion binding]; other site
278137005108	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137005109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137005110	NAD(P) binding site [chemical binding]; other site
278137005111	active site
278137005112	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137005113	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137005114	[2Fe-2S] cluster binding site [ion binding]; other site
278137005115	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
278137005116	alpha subunit interface [polypeptide binding]; other site
278137005117	active site
278137005118	substrate binding site [chemical binding]; other site
278137005119	Fe binding site [ion binding]; other site
278137005120	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
278137005121	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
278137005122	active site
278137005123	iron coordination sites [ion binding]; other site
278137005124	substrate binding pocket [chemical binding]; other site
278137005125	Uncharacterized conserved protein [Function unknown]; Region: COG2128
278137005126	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
278137005127	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137005128	Cytochrome P450; Region: p450; cl12078
278137005129	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137005130	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
278137005131	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
278137005132	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
278137005133	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137005134	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137005135	Cytochrome P450; Region: p450; cl12078
278137005136	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137005137	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
278137005138	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137005139	Cytochrome P450; Region: p450; cl12078
278137005140	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
278137005141	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
278137005142	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
278137005143	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
278137005144	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137005145	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
278137005146	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137005147	lipid-transfer protein; Provisional; Region: PRK07855
278137005148	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137005149	active site
278137005150	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
278137005151	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
278137005152	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137005153	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
278137005154	iron-sulfur cluster [ion binding]; other site
278137005155	[2Fe-2S] cluster binding site [ion binding]; other site
278137005156	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137005157	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137005158	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005159	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137005160	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005161	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005162	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005163	active site
278137005164	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
278137005165	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137005166	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
278137005167	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
278137005168	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137005169	Cytochrome P450; Region: p450; cl12078
278137005170	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
278137005171	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137005172	classical (c) SDRs; Region: SDR_c; cd05233
278137005173	NAD(P) binding site [chemical binding]; other site
278137005174	active site
278137005175	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137005176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137005177	NAD(P) binding site [chemical binding]; other site
278137005178	active site
278137005179	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
278137005180	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
278137005181	NAD binding site [chemical binding]; other site
278137005182	catalytic residues [active]
278137005183	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137005184	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137005185	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
278137005186	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137005187	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
278137005188	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137005189	active site
278137005190	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137005191	Permease; Region: Permease; pfam02405
278137005192	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137005193	Permease; Region: Permease; pfam02405
278137005194	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137005195	mce related protein; Region: MCE; pfam02470
278137005196	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137005197	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137005198	mce related protein; Region: MCE; pfam02470
278137005199	mce related protein; Region: MCE; pfam02470
278137005200	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137005201	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137005202	mce related protein; Region: MCE; pfam02470
278137005203	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137005204	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137005205	mce related protein; Region: MCE; pfam02470
278137005206	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137005207	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137005208	mce related protein; Region: MCE; pfam02470
278137005209	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137005210	Cytochrome P450; Region: p450; cl12078
278137005211	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005212	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005213	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
278137005214	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137005215	active site
278137005216	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
278137005217	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137005218	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
278137005219	dimer interface [polypeptide binding]; other site
278137005220	substrate binding site [chemical binding]; other site
278137005221	metal binding site [ion binding]; metal-binding site
278137005222	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137005223	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137005224	substrate binding site [chemical binding]; other site
278137005225	oxyanion hole (OAH) forming residues; other site
278137005226	trimer interface [polypeptide binding]; other site
278137005227	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
278137005228	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137005229	acyl-activating enzyme (AAE) consensus motif; other site
278137005230	AMP binding site [chemical binding]; other site
278137005231	active site
278137005232	CoA binding site [chemical binding]; other site
278137005233	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137005234	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
278137005235	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137005236	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
278137005237	acyl-activating enzyme (AAE) consensus motif; other site
278137005238	acyl-activating enzyme (AAE) consensus motif; other site
278137005239	putative AMP binding site [chemical binding]; other site
278137005240	putative active site [active]
278137005241	putative CoA binding site [chemical binding]; other site
278137005242	Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864
278137005243	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
278137005244	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
278137005245	substrate binding site; other site
278137005246	dimer interface; other site
278137005247	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137005248	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
278137005249	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
278137005250	DNA binding residues [nucleotide binding]
278137005251	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
278137005252	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
278137005253	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
278137005254	phosphate binding site [ion binding]; other site
278137005255	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
278137005256	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137005257	active site 2 [active]
278137005258	active site 1 [active]
278137005259	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
278137005260	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
278137005261	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
278137005262	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
278137005263	putative NAD(P) binding site [chemical binding]; other site
278137005264	active site
278137005265	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
278137005266	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
278137005267	active site
278137005268	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
278137005269	hypothetical protein; Provisional; Region: PRK07907
278137005270	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
278137005271	active site
278137005272	metal binding site [ion binding]; metal-binding site
278137005273	dimer interface [polypeptide binding]; other site
278137005274	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
278137005275	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
278137005276	catalytic triad [active]
278137005277	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
278137005278	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
278137005279	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
278137005280	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
278137005281	active site
278137005282	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
278137005283	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
278137005284	active site
278137005285	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137005286	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137005287	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137005288	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
278137005289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137005290	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137005291	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
278137005292	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
278137005293	catalytic site [active]
278137005294	putative active site [active]
278137005295	putative substrate binding site [chemical binding]; other site
278137005296	dimer interface [polypeptide binding]; other site
278137005297	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
278137005298	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
278137005299	classical (c) SDRs; Region: SDR_c; cd05233
278137005300	NAD(P) binding site [chemical binding]; other site
278137005301	active site
278137005302	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
278137005303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137005304	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137005305	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137005306	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005307	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005308	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
278137005309	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
278137005310	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
278137005311	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
278137005312	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
278137005313	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
278137005314	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
278137005315	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
278137005316	carboxyltransferase (CT) interaction site; other site
278137005317	biotinylation site [posttranslational modification]; other site
278137005318	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005319	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005320	active site
278137005321	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
278137005322	putative active site [active]
278137005323	putative catalytic site [active]
278137005324	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
278137005325	enoyl-CoA hydratase; Provisional; Region: PRK05870
278137005326	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137005327	substrate binding site [chemical binding]; other site
278137005328	oxyanion hole (OAH) forming residues; other site
278137005329	trimer interface [polypeptide binding]; other site
278137005330	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
278137005331	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005332	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005333	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
278137005334	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137005335	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137005336	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
278137005337	putative active site [active]
278137005338	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137005339	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137005340	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
278137005341	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
278137005342	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137005343	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
278137005344	putative acyl-acceptor binding pocket; other site
278137005345	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
278137005346	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
278137005347	putative acyl-acceptor binding pocket; other site
278137005348	Copper resistance protein D; Region: CopD; pfam05425
278137005349	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
278137005350	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
278137005351	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
278137005352	dimer interface [polypeptide binding]; other site
278137005353	ssDNA binding site [nucleotide binding]; other site
278137005354	tetramer (dimer of dimers) interface [polypeptide binding]; other site
278137005355	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
278137005356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137005357	Walker A/P-loop; other site
278137005358	ATP binding site [chemical binding]; other site
278137005359	Q-loop/lid; other site
278137005360	ABC transporter signature motif; other site
278137005361	Walker B; other site
278137005362	D-loop; other site
278137005363	H-loop/switch region; other site
278137005364	ABC transporter; Region: ABC_tran_2; pfam12848
278137005365	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
278137005366	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
278137005367	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
278137005368	active site
278137005369	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
278137005370	apolar tunnel; other site
278137005371	heme binding site [chemical binding]; other site
278137005372	dimerization interface [polypeptide binding]; other site
278137005373	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
278137005374	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137005375	active site
278137005376	Repair protein; Region: Repair_PSII; cl01535
278137005377	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137005378	active site
278137005379	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
278137005380	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
278137005381	Zn binding site [ion binding]; other site
278137005382	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
278137005383	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
278137005384	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
278137005385	nucleoside/Zn binding site; other site
278137005386	dimer interface [polypeptide binding]; other site
278137005387	catalytic motif [active]
278137005388	putative transposase OrfB; Reviewed; Region: PHA02517
278137005389	HTH-like domain; Region: HTH_21; pfam13276
278137005390	Integrase core domain; Region: rve; pfam00665
278137005391	Integrase core domain; Region: rve_3; pfam13683
278137005392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137005393	Transposase; Region: HTH_Tnp_1; cl17663
278137005394	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
278137005395	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
278137005396	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
278137005397	putative DNA binding site [nucleotide binding]; other site
278137005398	catalytic residue [active]
278137005399	putative H2TH interface [polypeptide binding]; other site
278137005400	putative catalytic residues [active]
278137005401	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
278137005402	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
278137005403	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
278137005404	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
278137005405	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
278137005406	trigger factor; Provisional; Region: tig; PRK01490
278137005407	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
278137005408	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
278137005409	Clp protease; Region: CLP_protease; pfam00574
278137005410	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
278137005411	oligomer interface [polypeptide binding]; other site
278137005412	active site residues [active]
278137005413	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
278137005414	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
278137005415	oligomer interface [polypeptide binding]; other site
278137005416	active site residues [active]
278137005417	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
278137005418	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
278137005419	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
278137005420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137005421	Walker A motif; other site
278137005422	ATP binding site [chemical binding]; other site
278137005423	Walker B motif; other site
278137005424	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
278137005425	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
278137005426	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
278137005427	active site
278137005428	TDP-binding site; other site
278137005429	acceptor substrate-binding pocket; other site
278137005430	homodimer interface [polypeptide binding]; other site
278137005431	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
278137005432	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
278137005433	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
278137005434	putative molybdopterin cofactor binding site [chemical binding]; other site
278137005435	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
278137005436	putative molybdopterin cofactor binding site; other site
278137005437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
278137005438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137005439	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
278137005440	dimerization interface [polypeptide binding]; other site
278137005441	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
278137005442	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
278137005443	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
278137005444	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
278137005445	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
278137005446	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
278137005447	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
278137005448	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
278137005449	PYR/PP interface [polypeptide binding]; other site
278137005450	dimer interface [polypeptide binding]; other site
278137005451	TPP binding site [chemical binding]; other site
278137005452	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
278137005453	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
278137005454	TPP-binding site; other site
278137005455	KduI/IolB family; Region: KduI; pfam04962
278137005456	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
278137005457	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
278137005458	substrate binding site [chemical binding]; other site
278137005459	ATP binding site [chemical binding]; other site
278137005460	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
278137005461	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137005462	DNA-binding site [nucleotide binding]; DNA binding site
278137005463	UTRA domain; Region: UTRA; pfam07702
278137005464	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
278137005465	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
278137005466	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
278137005467	putative ligand binding site [chemical binding]; other site
278137005468	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
278137005469	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
278137005470	TM-ABC transporter signature motif; other site
278137005471	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
278137005472	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
278137005473	Walker A/P-loop; other site
278137005474	ATP binding site [chemical binding]; other site
278137005475	Q-loop/lid; other site
278137005476	ABC transporter signature motif; other site
278137005477	Walker B; other site
278137005478	D-loop; other site
278137005479	H-loop/switch region; other site
278137005480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
278137005481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
278137005482	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
278137005483	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
278137005484	putative hydrophobic ligand binding site [chemical binding]; other site
278137005485	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
278137005486	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
278137005487	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
278137005488	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
278137005489	Metal-binding active site; metal-binding site
278137005490	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
278137005491	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
278137005492	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
278137005493	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
278137005494	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
278137005495	DNA binding site [nucleotide binding]
278137005496	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
278137005497	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
278137005498	putative ligand binding site [chemical binding]; other site
278137005499	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
278137005500	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
278137005501	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
278137005502	dimer interface [polypeptide binding]; other site
278137005503	PYR/PP interface [polypeptide binding]; other site
278137005504	TPP binding site [chemical binding]; other site
278137005505	substrate binding site [chemical binding]; other site
278137005506	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
278137005507	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
278137005508	TPP-binding site [chemical binding]; other site
278137005509	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
278137005510	GTP binding site; other site
278137005511	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
278137005512	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
278137005513	hypothetical protein; Provisional; Region: PRK06753
278137005514	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
278137005515	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
278137005516	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
278137005517	FMN-binding pocket [chemical binding]; other site
278137005518	flavin binding motif; other site
278137005519	phosphate binding motif [ion binding]; other site
278137005520	beta-alpha-beta structure motif; other site
278137005521	NAD binding pocket [chemical binding]; other site
278137005522	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137005523	catalytic loop [active]
278137005524	iron binding site [ion binding]; other site
278137005525	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
278137005526	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
278137005527	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
278137005528	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137005529	Uncharacterized conserved protein [Function unknown]; Region: COG3268
278137005530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137005531	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
278137005532	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
278137005533	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
278137005534	active site
278137005535	HIGH motif; other site
278137005536	nucleotide binding site [chemical binding]; other site
278137005537	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
278137005538	active site
278137005539	KMSKS motif; other site
278137005540	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
278137005541	tRNA binding surface [nucleotide binding]; other site
278137005542	anticodon binding site; other site
278137005543	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
278137005544	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
278137005545	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
278137005546	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
278137005547	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
278137005548	active site
278137005549	multimer interface [polypeptide binding]; other site
278137005550	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
278137005551	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
278137005552	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
278137005553	homodimer interface [polypeptide binding]; other site
278137005554	oligonucleotide binding site [chemical binding]; other site
278137005555	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
278137005556	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
278137005557	GTPase CgtA; Reviewed; Region: obgE; PRK12296
278137005558	GTP1/OBG; Region: GTP1_OBG; pfam01018
278137005559	Obg GTPase; Region: Obg; cd01898
278137005560	G1 box; other site
278137005561	GTP/Mg2+ binding site [chemical binding]; other site
278137005562	Switch I region; other site
278137005563	G2 box; other site
278137005564	G3 box; other site
278137005565	Switch II region; other site
278137005566	G4 box; other site
278137005567	G5 box; other site
278137005568	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
278137005569	gamma-glutamyl kinase; Provisional; Region: PRK05429
278137005570	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
278137005571	nucleotide binding site [chemical binding]; other site
278137005572	homotetrameric interface [polypeptide binding]; other site
278137005573	putative phosphate binding site [ion binding]; other site
278137005574	putative allosteric binding site; other site
278137005575	PUA domain; Region: PUA; pfam01472
278137005576	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005577	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137005578	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137005579	Cytochrome P450; Region: p450; cl12078
278137005580	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
278137005581	NAD-dependent deacetylase; Provisional; Region: PRK05333
278137005582	NAD+ binding site [chemical binding]; other site
278137005583	substrate binding site [chemical binding]; other site
278137005584	Zn binding site [ion binding]; other site
278137005585	NAD synthetase; Reviewed; Region: nadE; PRK02628
278137005586	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
278137005587	multimer interface [polypeptide binding]; other site
278137005588	active site
278137005589	catalytic triad [active]
278137005590	protein interface 1 [polypeptide binding]; other site
278137005591	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
278137005592	homodimer interface [polypeptide binding]; other site
278137005593	NAD binding pocket [chemical binding]; other site
278137005594	ATP binding pocket [chemical binding]; other site
278137005595	Mg binding site [ion binding]; other site
278137005596	active-site loop [active]
278137005597	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
278137005598	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
278137005599	substrate binding site [chemical binding]; other site
278137005600	ATP binding site [chemical binding]; other site
278137005601	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
278137005602	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
278137005603	putative catalytic cysteine [active]
278137005604	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
278137005605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137005606	Walker A motif; other site
278137005607	ATP binding site [chemical binding]; other site
278137005608	Walker B motif; other site
278137005609	arginine finger; other site
278137005610	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
278137005611	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
278137005612	metal ion-dependent adhesion site (MIDAS); other site
278137005613	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
278137005614	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137005615	Predicted dehydrogenase [General function prediction only]; Region: COG0579
278137005616	hydroxyglutarate oxidase; Provisional; Region: PRK11728
278137005617	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
278137005618	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
278137005619	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137005620	nucleotide binding site [chemical binding]; other site
278137005621	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
278137005622	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
278137005623	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137005624	DNA-binding site [nucleotide binding]; DNA binding site
278137005625	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
278137005626	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
278137005627	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
278137005628	active site
278137005629	(T/H)XGH motif; other site
278137005630	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
278137005631	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137005632	catalytic core [active]
278137005633	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
278137005634	active site
278137005635	catalytic triad [active]
278137005636	oxyanion hole [active]
278137005637	EDD domain protein, DegV family; Region: DegV; TIGR00762
278137005638	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
278137005639	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137005640	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137005641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137005642	NAD(P) binding site [chemical binding]; other site
278137005643	active site
278137005644	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137005645	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137005646	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137005647	Transposase; Region: HTH_Tnp_1; pfam01527
278137005648	putative transposase OrfB; Reviewed; Region: PHA02517
278137005649	HTH-like domain; Region: HTH_21; pfam13276
278137005650	Integrase core domain; Region: rve; pfam00665
278137005651	Integrase core domain; Region: rve_3; pfam13683
278137005652	Helix-hairpin-helix motif; Region: HHH; pfam00633
278137005653	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
278137005654	Competence protein; Region: Competence; pfam03772
278137005655	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
278137005656	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
278137005657	DNA polymerase III, delta subunit; Region: holA; TIGR01128
278137005658	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
278137005659	Uncharacterized conserved protein [Function unknown]; Region: COG2308
278137005660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
278137005661	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
278137005662	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
278137005663	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
278137005664	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
278137005665	ribonuclease Z; Reviewed; Region: PRK00055
278137005666	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
278137005667	FOG: CBS domain [General function prediction only]; Region: COG0517
278137005668	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
278137005669	PemK-like protein; Region: PemK; pfam02452
278137005670	GTP-binding protein LepA; Provisional; Region: PRK05433
278137005671	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
278137005672	G1 box; other site
278137005673	putative GEF interaction site [polypeptide binding]; other site
278137005674	GTP/Mg2+ binding site [chemical binding]; other site
278137005675	Switch I region; other site
278137005676	G2 box; other site
278137005677	G3 box; other site
278137005678	Switch II region; other site
278137005679	G4 box; other site
278137005680	G5 box; other site
278137005681	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
278137005682	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
278137005683	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
278137005684	PknH-like extracellular domain; Region: PknH_C; pfam14032
278137005685	PknH-like extracellular domain; Region: PknH_C; pfam14032
278137005686	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
278137005687	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
278137005688	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
278137005689	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
278137005690	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
278137005691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137005692	dimer interface [polypeptide binding]; other site
278137005693	conserved gate region; other site
278137005694	putative PBP binding loops; other site
278137005695	ABC-ATPase subunit interface; other site
278137005696	sulfate transport protein; Provisional; Region: cysT; CHL00187
278137005697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137005698	dimer interface [polypeptide binding]; other site
278137005699	conserved gate region; other site
278137005700	putative PBP binding loops; other site
278137005701	ABC-ATPase subunit interface; other site
278137005702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137005703	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
278137005704	Walker A/P-loop; other site
278137005705	ATP binding site [chemical binding]; other site
278137005706	Q-loop/lid; other site
278137005707	ABC transporter signature motif; other site
278137005708	Walker B; other site
278137005709	D-loop; other site
278137005710	H-loop/switch region; other site
278137005711	TOBE-like domain; Region: TOBE_3; pfam12857
278137005712	Domain of unknown function DUF21; Region: DUF21; pfam01595
278137005713	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
278137005714	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
278137005715	Domain of unknown function DUF21; Region: DUF21; pfam01595
278137005716	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
278137005717	Transporter associated domain; Region: CorC_HlyC; pfam03471
278137005718	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
278137005719	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
278137005720	putative active site [active]
278137005721	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
278137005722	putative active site [active]
278137005723	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
278137005724	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
278137005725	Active Sites [active]
278137005726	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
278137005727	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
278137005728	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
278137005729	coproporphyrinogen III oxidase; Validated; Region: PRK05628
278137005730	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137005731	FeS/SAM binding site; other site
278137005732	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
278137005733	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
278137005734	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137005735	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
278137005736	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137005737	active site
278137005738	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137005739	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
278137005740	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
278137005741	KR domain; Region: KR; pfam08659
278137005742	putative NADP binding site [chemical binding]; other site
278137005743	active site
278137005744	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137005745	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
278137005746	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
278137005747	acyl-activating enzyme (AAE) consensus motif; other site
278137005748	active site
278137005749	AMP binding site [chemical binding]; other site
278137005750	substrate binding site [chemical binding]; other site
278137005751	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
278137005752	Condensation domain; Region: Condensation; pfam00668
278137005753	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
278137005754	Nonribosomal peptide synthase; Region: NRPS; pfam08415
278137005755	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
278137005756	acyl-activating enzyme (AAE) consensus motif; other site
278137005757	AMP binding site [chemical binding]; other site
278137005758	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
278137005759	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137005760	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
278137005761	active site
278137005762	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137005763	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
278137005764	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
278137005765	NADP binding site [chemical binding]; other site
278137005766	active site
278137005767	Condensation domain; Region: Condensation; pfam00668
278137005768	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
278137005769	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
278137005770	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
278137005771	acyl-activating enzyme (AAE) consensus motif; other site
278137005772	AMP binding site [chemical binding]; other site
278137005773	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137005774	Condensation domain; Region: Condensation; pfam00668
278137005775	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
278137005776	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
278137005777	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137005778	Condensation domain; Region: Condensation; pfam00668
278137005779	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
278137005780	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
278137005781	acyl-activating enzyme (AAE) consensus motif; other site
278137005782	AMP binding site [chemical binding]; other site
278137005783	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137005784	Condensation domain; Region: Condensation; pfam00668
278137005785	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
278137005786	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
278137005787	MbtH-like protein; Region: MbtH; pfam03621
278137005788	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
278137005789	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
278137005790	HTH domain; Region: HTH_11; cl17392
278137005791	chaperone protein DnaJ; Provisional; Region: PRK14278
278137005792	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
278137005793	HSP70 interaction site [polypeptide binding]; other site
278137005794	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
278137005795	Zn binding sites [ion binding]; other site
278137005796	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
278137005797	dimer interface [polypeptide binding]; other site
278137005798	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
278137005799	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
278137005800	Transport protein; Region: actII; TIGR00833
278137005801	K homology RNA-binding domain; Region: KH; smart00322
278137005802	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
278137005803	PhoH-like protein; Region: PhoH; pfam02562
278137005804	metal-binding heat shock protein; Provisional; Region: PRK00016
278137005805	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
278137005806	Domain of unknown function DUF21; Region: DUF21; pfam01595
278137005807	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
278137005808	Transporter associated domain; Region: CorC_HlyC; smart01091
278137005809	GTPase Era; Reviewed; Region: era; PRK00089
278137005810	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
278137005811	G1 box; other site
278137005812	GTP/Mg2+ binding site [chemical binding]; other site
278137005813	Switch I region; other site
278137005814	G2 box; other site
278137005815	Switch II region; other site
278137005816	G3 box; other site
278137005817	G4 box; other site
278137005818	G5 box; other site
278137005819	KH domain; Region: KH_2; pfam07650
278137005820	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
278137005821	amidase; Provisional; Region: PRK06061
278137005822	Amidase; Region: Amidase; cl11426
278137005823	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
278137005824	Recombination protein O N terminal; Region: RecO_N; pfam11967
278137005825	Recombination protein O C terminal; Region: RecO_C; pfam02565
278137005826	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
278137005827	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
278137005828	catalytic residue [active]
278137005829	putative FPP diphosphate  binding site; other site
278137005830	putative FPP binding hydrophobic cleft; other site
278137005831	dimer interface [polypeptide binding]; other site
278137005832	putative IPP diphosphate binding site; other site
278137005833	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
278137005834	metal binding site 2 [ion binding]; metal-binding site
278137005835	putative DNA binding helix; other site
278137005836	metal binding site 1 [ion binding]; metal-binding site
278137005837	dimer interface [polypeptide binding]; other site
278137005838	structural Zn2+ binding site [ion binding]; other site
278137005839	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137005840	dimerization interface [polypeptide binding]; other site
278137005841	putative DNA binding site [nucleotide binding]; other site
278137005842	putative Zn2+ binding site [ion binding]; other site
278137005843	glycyl-tRNA synthetase; Provisional; Region: PRK04173
278137005844	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
278137005845	motif 1; other site
278137005846	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
278137005847	active site
278137005848	motif 2; other site
278137005849	motif 3; other site
278137005850	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
278137005851	anticodon binding site; other site
278137005852	Repair protein; Region: Repair_PSII; pfam04536
278137005853	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
278137005854	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
278137005855	Zn2+ binding site [ion binding]; other site
278137005856	Mg2+ binding site [ion binding]; other site
278137005857	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
278137005858	DNA primase; Validated; Region: dnaG; PRK05667
278137005859	CHC2 zinc finger; Region: zf-CHC2; cl17510
278137005860	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
278137005861	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
278137005862	active site
278137005863	metal binding site [ion binding]; metal-binding site
278137005864	interdomain interaction site; other site
278137005865	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
278137005866	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
278137005867	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
278137005868	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137005869	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137005870	active site
278137005871	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
278137005872	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137005873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137005874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137005875	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137005876	MarR family; Region: MarR; pfam01047
278137005877	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
278137005878	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
278137005879	Walker A/P-loop; other site
278137005880	ATP binding site [chemical binding]; other site
278137005881	Q-loop/lid; other site
278137005882	ABC transporter signature motif; other site
278137005883	Walker B; other site
278137005884	D-loop; other site
278137005885	H-loop/switch region; other site
278137005886	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
278137005887	Walker A/P-loop; other site
278137005888	ATP binding site [chemical binding]; other site
278137005889	Q-loop/lid; other site
278137005890	ABC transporter signature motif; other site
278137005891	Walker B; other site
278137005892	D-loop; other site
278137005893	H-loop/switch region; other site
278137005894	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
278137005895	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
278137005896	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
278137005897	Uncharacterized conserved protein [Function unknown]; Region: COG2128
278137005898	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
278137005899	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137005900	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137005901	metal binding site [ion binding]; metal-binding site
278137005902	active site
278137005903	I-site; other site
278137005904	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137005905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
278137005906	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137005907	GAF domain; Region: GAF; pfam01590
278137005908	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
278137005909	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901
278137005910	active site
278137005911	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
278137005912	Mechanosensitive ion channel; Region: MS_channel; pfam00924
278137005913	Domain of unknown function (DUF427); Region: DUF427; pfam04248
278137005914	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
278137005915	POT family; Region: PTR2; cl17359
278137005916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137005917	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
278137005918	putative active site [active]
278137005919	putative metal binding site [ion binding]; other site
278137005920	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
278137005921	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137005922	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137005923	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
278137005924	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
278137005925	active site
278137005926	Zn binding site [ion binding]; other site
278137005927	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137005928	AzlC protein; Region: AzlC; cl00570
278137005929	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
278137005930	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137005931	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137005932	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137005933	[2Fe-2S] cluster binding site [ion binding]; other site
278137005934	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137005935	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
278137005936	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137005937	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137005938	active site
278137005939	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137005940	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137005941	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137005942	classical (c) SDRs; Region: SDR_c; cd05233
278137005943	NAD(P) binding site [chemical binding]; other site
278137005944	active site
278137005945	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
278137005946	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
278137005947	Walker A/P-loop; other site
278137005948	ATP binding site [chemical binding]; other site
278137005949	Q-loop/lid; other site
278137005950	ABC transporter signature motif; other site
278137005951	Walker B; other site
278137005952	D-loop; other site
278137005953	H-loop/switch region; other site
278137005954	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
278137005955	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
278137005956	Walker A/P-loop; other site
278137005957	ATP binding site [chemical binding]; other site
278137005958	Q-loop/lid; other site
278137005959	ABC transporter signature motif; other site
278137005960	Walker B; other site
278137005961	D-loop; other site
278137005962	H-loop/switch region; other site
278137005963	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
278137005964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137005965	putative PBP binding loops; other site
278137005966	dimer interface [polypeptide binding]; other site
278137005967	ABC-ATPase subunit interface; other site
278137005968	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
278137005969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137005970	dimer interface [polypeptide binding]; other site
278137005971	conserved gate region; other site
278137005972	putative PBP binding loops; other site
278137005973	ABC-ATPase subunit interface; other site
278137005974	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
278137005975	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
278137005976	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137005977	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137005978	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
278137005979	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137005980	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
278137005981	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
278137005982	NAD binding site [chemical binding]; other site
278137005983	catalytic Zn binding site [ion binding]; other site
278137005984	substrate binding site [chemical binding]; other site
278137005985	structural Zn binding site [ion binding]; other site
278137005986	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
278137005987	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
278137005988	putative active site [active]
278137005989	metal binding site [ion binding]; metal-binding site
278137005990	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137005991	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137005992	S-adenosylmethionine binding site [chemical binding]; other site
278137005993	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
278137005994	Beta-lactamase; Region: Beta-lactamase; pfam00144
278137005995	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
278137005996	diacylglycerol kinase; Reviewed; Region: PRK11914
278137005997	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
278137005998	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
278137005999	FAD binding domain; Region: FAD_binding_4; pfam01565
278137006000	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137006001	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137006002	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
278137006003	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
278137006004	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
278137006005	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
278137006006	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
278137006007	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
278137006008	dimer interface [polypeptide binding]; other site
278137006009	active site
278137006010	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
278137006011	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
278137006012	dimer interface [polypeptide binding]; other site
278137006013	active site
278137006014	acyl carrier protein; Provisional; Region: acpP; PRK00982
278137006015	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
278137006016	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
278137006017	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
278137006018	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
278137006019	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
278137006020	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
278137006021	dimer interface [polypeptide binding]; other site
278137006022	TPP-binding site [chemical binding]; other site
278137006023	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
278137006024	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
278137006025	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
278137006026	dimer interface [polypeptide binding]; other site
278137006027	catalytic triad [active]
278137006028	MASE1; Region: MASE1; cl17823
278137006029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
278137006030	PAS domain; Region: PAS_9; pfam13426
278137006031	putative active site [active]
278137006032	heme pocket [chemical binding]; other site
278137006033	PAS domain S-box; Region: sensory_box; TIGR00229
278137006034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
278137006035	putative active site [active]
278137006036	heme pocket [chemical binding]; other site
278137006037	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137006038	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137006039	metal binding site [ion binding]; metal-binding site
278137006040	active site
278137006041	I-site; other site
278137006042	SOUL heme-binding protein; Region: SOUL; pfam04832
278137006043	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
278137006044	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137006045	active site
278137006046	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
278137006047	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
278137006048	Low molecular weight phosphatase family; Region: LMWPc; cd00115
278137006049	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
278137006050	active site
278137006051	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
278137006052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137006053	motif II; other site
278137006054	Uncharacterized conserved protein [Function unknown]; Region: COG0327
278137006055	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
278137006056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
278137006057	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
278137006058	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
278137006059	Putative zinc ribbon domain; Region: DUF164; pfam02591
278137006060	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
278137006061	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
278137006062	active site
278137006063	RNA/DNA hybrid binding site [nucleotide binding]; other site
278137006064	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137006065	catalytic core [active]
278137006066	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137006067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137006068	sequence-specific DNA binding site [nucleotide binding]; other site
278137006069	salt bridge; other site
278137006070	Cupin domain; Region: Cupin_2; pfam07883
278137006071	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
278137006072	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137006073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137006074	S-adenosylmethionine binding site [chemical binding]; other site
278137006075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137006076	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137006077	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
278137006078	putative active site; other site
278137006079	putative metal binding residues [ion binding]; other site
278137006080	signature motif; other site
278137006081	putative triphosphate binding site [ion binding]; other site
278137006082	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
278137006083	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
278137006084	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
278137006085	acyl-activating enzyme (AAE) consensus motif; other site
278137006086	active site
278137006087	enoyl-CoA hydratase; Provisional; Region: PRK08140
278137006088	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137006089	substrate binding site [chemical binding]; other site
278137006090	oxyanion hole (OAH) forming residues; other site
278137006091	trimer interface [polypeptide binding]; other site
278137006092	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
278137006093	oligomerization interface [polypeptide binding]; other site
278137006094	active site
278137006095	metal binding site [ion binding]; metal-binding site
278137006096	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
278137006097	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137006098	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
278137006099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137006100	Coenzyme A binding pocket [chemical binding]; other site
278137006101	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
278137006102	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137006103	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
278137006104	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
278137006105	active site
278137006106	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
278137006107	catalytic triad [active]
278137006108	dimer interface [polypeptide binding]; other site
278137006109	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
278137006110	active site
278137006111	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
278137006112	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
278137006113	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
278137006114	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
278137006115	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
278137006116	metal binding triad; other site
278137006117	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
278137006118	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
278137006119	metal binding triad; other site
278137006120	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
278137006121	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137006122	CoenzymeA binding site [chemical binding]; other site
278137006123	subunit interaction site [polypeptide binding]; other site
278137006124	PHB binding site; other site
278137006125	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137006126	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137006127	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
278137006128	structural tetrad; other site
278137006129	PQQ-like domain; Region: PQQ_2; pfam13360
278137006130	DoxX; Region: DoxX; pfam07681
278137006131	glutamine synthetase, type I; Region: GlnA; TIGR00653
278137006132	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
278137006133	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
278137006134	RDD family; Region: RDD; pfam06271
278137006135	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137006136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137006137	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137006138	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
278137006139	lipoyl synthase; Provisional; Region: PRK05481
278137006140	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137006141	FeS/SAM binding site; other site
278137006142	lipoate-protein ligase B; Provisional; Region: PRK14345
278137006143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137006144	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
278137006145	NAD(P) binding site [chemical binding]; other site
278137006146	active site
278137006147	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
278137006148	E3 interaction surface; other site
278137006149	lipoyl attachment site [posttranslational modification]; other site
278137006150	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
278137006151	E3 interaction surface; other site
278137006152	lipoyl attachment site [posttranslational modification]; other site
278137006153	e3 binding domain; Region: E3_binding; pfam02817
278137006154	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
278137006155	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
278137006156	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137006157	classical (c) SDRs; Region: SDR_c; cd05233
278137006158	short chain dehydrogenase; Provisional; Region: PRK08267
278137006159	NAD(P) binding site [chemical binding]; other site
278137006160	active site
278137006161	multifunctional aminopeptidase A; Provisional; Region: PRK00913
278137006162	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
278137006163	interface (dimer of trimers) [polypeptide binding]; other site
278137006164	Substrate-binding/catalytic site; other site
278137006165	Zn-binding sites [ion binding]; other site
278137006166	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
278137006167	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
278137006168	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
278137006169	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
278137006170	homodimer interface [polypeptide binding]; other site
278137006171	substrate-cofactor binding pocket; other site
278137006172	catalytic residue [active]
278137006173	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
278137006174	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
278137006175	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
278137006176	putative dimer interface [polypeptide binding]; other site
278137006177	active site pocket [active]
278137006178	putative cataytic base [active]
278137006179	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
278137006180	Glycerate kinase family; Region: Gly_kinase; cl00841
278137006181	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
278137006182	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
278137006183	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
278137006184	substrate binding site [chemical binding]; other site
278137006185	ATP binding site [chemical binding]; other site
278137006186	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
278137006187	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
278137006188	dimer interface [polypeptide binding]; other site
278137006189	active site
278137006190	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
278137006191	Ligand Binding Site [chemical binding]; other site
278137006192	Molecular Tunnel; other site
278137006193	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
278137006194	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
278137006195	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
278137006196	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
278137006197	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
278137006198	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
278137006199	heme bH binding site [chemical binding]; other site
278137006200	intrachain domain interface; other site
278137006201	heme bL binding site [chemical binding]; other site
278137006202	interchain domain interface [polypeptide binding]; other site
278137006203	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
278137006204	Qo binding site; other site
278137006205	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
278137006206	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
278137006207	iron-sulfur cluster [ion binding]; other site
278137006208	[2Fe-2S] cluster binding site [ion binding]; other site
278137006209	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
278137006210	Cytochrome c; Region: Cytochrom_C; pfam00034
278137006211	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
278137006212	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
278137006213	Subunit I/III interface [polypeptide binding]; other site
278137006214	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
278137006215	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
278137006216	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
278137006217	hypothetical protein; Validated; Region: PRK07883
278137006218	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
278137006219	active site
278137006220	catalytic site [active]
278137006221	substrate binding site [chemical binding]; other site
278137006222	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
278137006223	GIY-YIG motif/motif A; other site
278137006224	active site
278137006225	catalytic site [active]
278137006226	putative DNA binding site [nucleotide binding]; other site
278137006227	metal binding site [ion binding]; metal-binding site
278137006228	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137006229	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137006230	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
278137006231	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137006232	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137006233	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
278137006234	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137006235	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
278137006236	acyl-activating enzyme (AAE) consensus motif; other site
278137006237	putative AMP binding site [chemical binding]; other site
278137006238	putative active site [active]
278137006239	putative CoA binding site [chemical binding]; other site
278137006240	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
278137006241	putative hydrophobic ligand binding site [chemical binding]; other site
278137006242	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
278137006243	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
278137006244	P loop; other site
278137006245	Nucleotide binding site [chemical binding]; other site
278137006246	DTAP/Switch II; other site
278137006247	Switch I; other site
278137006248	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137006249	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
278137006250	putative acyl-acceptor binding pocket; other site
278137006251	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
278137006252	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
278137006253	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137006254	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137006255	active site
278137006256	ATP binding site [chemical binding]; other site
278137006257	substrate binding site [chemical binding]; other site
278137006258	activation loop (A-loop); other site
278137006259	Helix-turn-helix domain; Region: HTH_17; cl17695
278137006260	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
278137006261	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
278137006262	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
278137006263	substrate binding pocket [chemical binding]; other site
278137006264	chain length determination region; other site
278137006265	substrate-Mg2+ binding site; other site
278137006266	catalytic residues [active]
278137006267	aspartate-rich region 1; other site
278137006268	active site lid residues [active]
278137006269	aspartate-rich region 2; other site
278137006270	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
278137006271	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
278137006272	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
278137006273	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
278137006274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
278137006275	MraZ protein; Region: MraZ; pfam02381
278137006276	MraZ protein; Region: MraZ; pfam02381
278137006277	MraW methylase family; Region: Methyltransf_5; cl17771
278137006278	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
278137006279	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
278137006280	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
278137006281	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
278137006282	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
278137006283	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
278137006284	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
278137006285	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
278137006286	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
278137006287	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
278137006288	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
278137006289	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
278137006290	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
278137006291	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
278137006292	Mg++ binding site [ion binding]; other site
278137006293	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
278137006294	putative catalytic motif [active]
278137006295	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
278137006296	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
278137006297	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
278137006298	cell division protein FtsW; Region: ftsW; TIGR02614
278137006299	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
278137006300	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
278137006301	active site
278137006302	homodimer interface [polypeptide binding]; other site
278137006303	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
278137006304	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
278137006305	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
278137006306	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
278137006307	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
278137006308	Cell division protein FtsQ; Region: FtsQ; pfam03799
278137006309	cell division protein FtsZ; Validated; Region: PRK09330
278137006310	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
278137006311	nucleotide binding site [chemical binding]; other site
278137006312	SulA interaction site; other site
278137006313	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
278137006314	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
278137006315	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
278137006316	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
278137006317	catalytic residue [active]
278137006318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
278137006319	Predicted integral membrane protein [Function unknown]; Region: COG0762
278137006320	DivIVA domain; Region: DivI1A_domain; TIGR03544
278137006321	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
278137006322	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
278137006323	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137006324	active site
278137006325	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
278137006326	putative hydrophobic ligand binding site [chemical binding]; other site
278137006327	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137006328	TIGR01777 family protein; Region: yfcH
278137006329	NAD(P) binding site [chemical binding]; other site
278137006330	active site
278137006331	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
278137006332	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
278137006333	catalytic triad [active]
278137006334	Calx-beta domain; Region: Calx-beta; cl02522
278137006335	Calx-beta domain; Region: Calx-beta; pfam03160
278137006336	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
278137006337	active site
278137006338	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
278137006339	Calx-beta domain; Region: Calx-beta; pfam03160
278137006340	Cellulose binding domain; Region: CBM_2; pfam00553
278137006341	Calx-beta domain; Region: Calx-beta; cl02522
278137006342	CBD_II domain; Region: CBD_II; smart00637
278137006343	Calx-beta domain; Region: Calx-beta; pfam03160
278137006344	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
278137006345	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
278137006346	Calx-beta domain; Region: Calx-beta; pfam03160
278137006347	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
278137006348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137006349	active site
278137006350	phosphorylation site [posttranslational modification]
278137006351	intermolecular recognition site; other site
278137006352	dimerization interface [polypeptide binding]; other site
278137006353	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
278137006354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137006355	ATP binding site [chemical binding]; other site
278137006356	Mg2+ binding site [ion binding]; other site
278137006357	G-X-G motif; other site
278137006358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
278137006359	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
278137006360	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
278137006361	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137006362	Ligand Binding Site [chemical binding]; other site
278137006363	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137006364	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
278137006365	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137006366	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
278137006367	DNA-binding interface [nucleotide binding]; DNA binding site
278137006368	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137006369	iron-sulfur cluster [ion binding]; other site
278137006370	[2Fe-2S] cluster binding site [ion binding]; other site
278137006371	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
278137006372	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137006373	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
278137006374	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
278137006375	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
278137006376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137006377	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
278137006378	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
278137006379	[4Fe-4S] binding site [ion binding]; other site
278137006380	molybdopterin cofactor binding site; other site
278137006381	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
278137006382	molybdopterin cofactor binding site; other site
278137006383	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
278137006384	Flavodoxin; Region: Flavodoxin_1; pfam00258
278137006385	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
278137006386	FAD binding pocket [chemical binding]; other site
278137006387	FAD binding motif [chemical binding]; other site
278137006388	catalytic residues [active]
278137006389	NAD binding pocket [chemical binding]; other site
278137006390	phosphate binding motif [ion binding]; other site
278137006391	beta-alpha-beta structure motif; other site
278137006392	Acyltransferase family; Region: Acyl_transf_3; pfam01757
278137006393	hypothetical protein; Provisional; Region: PRK07906
278137006394	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
278137006395	putative metal binding site [ion binding]; other site
278137006396	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
278137006397	substrate binding site [chemical binding]; other site
278137006398	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
278137006399	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
278137006400	quinone interaction residues [chemical binding]; other site
278137006401	active site
278137006402	catalytic residues [active]
278137006403	FMN binding site [chemical binding]; other site
278137006404	substrate binding site [chemical binding]; other site
278137006405	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
278137006406	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137006407	catalytic core [active]
278137006408	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
278137006409	conserved hypothetical protein; Region: TIGR03843
278137006410	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
278137006411	active site
278137006412	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
278137006413	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
278137006414	active site
278137006415	HIGH motif; other site
278137006416	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
278137006417	active site
278137006418	KMSKS motif; other site
278137006419	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
278137006420	putative tRNA binding surface [nucleotide binding]; other site
278137006421	short chain dehydrogenase; Provisional; Region: PRK05872
278137006422	classical (c) SDRs; Region: SDR_c; cd05233
278137006423	NAD(P) binding site [chemical binding]; other site
278137006424	active site
278137006425	Uncharacterized conserved protein [Function unknown]; Region: COG5361
278137006426	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
278137006427	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
278137006428	PAC2 family; Region: PAC2; pfam09754
278137006429	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
278137006430	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
278137006431	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
278137006432	substrate binding pocket [chemical binding]; other site
278137006433	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
278137006434	B12 binding site [chemical binding]; other site
278137006435	cobalt ligand [ion binding]; other site
278137006436	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
278137006437	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
278137006438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137006439	motif II; other site
278137006440	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
278137006441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137006442	putative substrate translocation pore; other site
278137006443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137006444	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
278137006445	homodimer interface [polypeptide binding]; other site
278137006446	putative metal binding site [ion binding]; other site
278137006447	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
278137006448	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
278137006449	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
278137006450	Predicted membrane protein [Function unknown]; Region: COG3918
278137006451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137006452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137006453	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
278137006454	active site
278137006455	diiron metal binding site [ion binding]; other site
278137006456	DinB superfamily; Region: DinB_2; pfam12867
278137006457	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
278137006458	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
278137006459	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
278137006460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137006461	S-adenosylmethionine binding site [chemical binding]; other site
278137006462	Protein of unknown function (DUF503); Region: DUF503; pfam04456
278137006463	proteasome ATPase; Region: pup_AAA; TIGR03689
278137006464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137006465	Walker A motif; other site
278137006466	ATP binding site [chemical binding]; other site
278137006467	Walker B motif; other site
278137006468	arginine finger; other site
278137006469	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
278137006470	Rrf2 family protein; Region: rrf2_super; TIGR00738
278137006471	Transcriptional regulator; Region: Rrf2; cl17282
278137006472	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
278137006473	Pup-like protein; Region: Pup; pfam05639
278137006474	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
278137006475	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
278137006476	active site
278137006477	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
278137006478	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
278137006479	active site
278137006480	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
278137006481	hydroxyglutarate oxidase; Provisional; Region: PRK11728
278137006482	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
278137006483	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
278137006484	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
278137006485	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
278137006486	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
278137006487	hydroxyglutarate oxidase; Provisional; Region: PRK11728
278137006488	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137006489	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137006490	[2Fe-2S] cluster binding site [ion binding]; other site
278137006491	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
278137006492	hydrophobic ligand binding site; other site
278137006493	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
278137006494	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137006495	tetramerization interface [polypeptide binding]; other site
278137006496	NAD(P) binding site [chemical binding]; other site
278137006497	catalytic residues [active]
278137006498	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
278137006499	choline dehydrogenase; Validated; Region: PRK02106
278137006500	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
278137006501	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
278137006502	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
278137006503	ligand binding site [chemical binding]; other site
278137006504	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
278137006505	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
278137006506	metal binding triad; other site
278137006507	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
278137006508	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137006509	Bacterial transcriptional regulator; Region: IclR; pfam01614
278137006510	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
278137006511	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
278137006512	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137006513	S-adenosylmethionine binding site [chemical binding]; other site
278137006514	Predicted transcriptional regulator [Transcription]; Region: COG2378
278137006515	WYL domain; Region: WYL; pfam13280
278137006516	Predicted transcriptional regulator [Transcription]; Region: COG2378
278137006517	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
278137006518	WYL domain; Region: WYL; pfam13280
278137006519	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
278137006520	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
278137006521	Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945
278137006522	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
278137006523	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137006524	ATP binding site [chemical binding]; other site
278137006525	putative Mg++ binding site [ion binding]; other site
278137006526	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137006527	nucleotide binding region [chemical binding]; other site
278137006528	ATP-binding site [chemical binding]; other site
278137006529	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
278137006530	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
278137006531	5'-3' exonuclease; Region: 53EXOc; smart00475
278137006532	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
278137006533	active site
278137006534	metal binding site 1 [ion binding]; metal-binding site
278137006535	putative 5' ssDNA interaction site; other site
278137006536	metal binding site 3; metal-binding site
278137006537	metal binding site 2 [ion binding]; metal-binding site
278137006538	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
278137006539	putative DNA binding site [nucleotide binding]; other site
278137006540	putative metal binding site [ion binding]; other site
278137006541	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
278137006542	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
278137006543	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
278137006544	active site
278137006545	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
278137006546	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
278137006547	classical (c) SDRs; Region: SDR_c; cd05233
278137006548	NAD(P) binding site [chemical binding]; other site
278137006549	active site
278137006550	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
278137006551	active site
278137006552	putative homodimer interface [polypeptide binding]; other site
278137006553	SAM binding site [chemical binding]; other site
278137006554	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
278137006555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137006556	S-adenosylmethionine binding site [chemical binding]; other site
278137006557	Phosphotransferase enzyme family; Region: APH; pfam01636
278137006558	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
278137006559	substrate binding site [chemical binding]; other site
278137006560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137006561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137006562	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
278137006563	active site
278137006564	SAM binding site [chemical binding]; other site
278137006565	homodimer interface [polypeptide binding]; other site
278137006566	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
278137006567	active site
278137006568	SAM binding site [chemical binding]; other site
278137006569	homodimer interface [polypeptide binding]; other site
278137006570	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
278137006571	Precorrin-8X methylmutase; Region: CbiC; pfam02570
278137006572	precorrin-3B synthase; Region: CobG; TIGR02435
278137006573	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
278137006574	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
278137006575	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
278137006576	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
278137006577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137006578	ABC-ATPase subunit interface; other site
278137006579	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
278137006580	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
278137006581	Walker A/P-loop; other site
278137006582	ATP binding site [chemical binding]; other site
278137006583	Q-loop/lid; other site
278137006584	ABC transporter signature motif; other site
278137006585	Walker B; other site
278137006586	D-loop; other site
278137006587	H-loop/switch region; other site
278137006588	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
278137006589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137006590	dimer interface [polypeptide binding]; other site
278137006591	conserved gate region; other site
278137006592	putative PBP binding loops; other site
278137006593	ABC-ATPase subunit interface; other site
278137006594	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
278137006595	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
278137006596	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
278137006597	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
278137006598	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
278137006599	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
278137006600	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
278137006601	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137006602	active site
278137006603	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
278137006604	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
278137006605	putative active site [active]
278137006606	catalytic triad [active]
278137006607	putative dimer interface [polypeptide binding]; other site
278137006608	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
278137006609	Ligand binding site; other site
278137006610	Putative Catalytic site; other site
278137006611	DXD motif; other site
278137006612	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
278137006613	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137006614	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137006615	DNA binding site [nucleotide binding]
278137006616	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
278137006617	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
278137006618	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
278137006619	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137006620	substrate binding pocket [chemical binding]; other site
278137006621	catalytic triad [active]
278137006622	tyramine oxidase; Provisional; Region: tynA; PRK11504
278137006623	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
278137006624	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
278137006625	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
278137006626	hypothetical protein; Provisional; Region: PRK02237
278137006627	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
278137006628	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
278137006629	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
278137006630	Predicted membrane protein [Function unknown]; Region: COG2259
278137006631	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
278137006632	enoyl-CoA hydratase; Provisional; Region: PRK08260
278137006633	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137006634	substrate binding site [chemical binding]; other site
278137006635	oxyanion hole (OAH) forming residues; other site
278137006636	trimer interface [polypeptide binding]; other site
278137006637	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
278137006638	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
278137006639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137006640	dimer interface [polypeptide binding]; other site
278137006641	conserved gate region; other site
278137006642	putative PBP binding loops; other site
278137006643	ABC-ATPase subunit interface; other site
278137006644	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
278137006645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137006646	dimer interface [polypeptide binding]; other site
278137006647	conserved gate region; other site
278137006648	putative PBP binding loops; other site
278137006649	ABC-ATPase subunit interface; other site
278137006650	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
278137006651	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
278137006652	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
278137006653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137006654	Walker A/P-loop; other site
278137006655	ATP binding site [chemical binding]; other site
278137006656	Q-loop/lid; other site
278137006657	ABC transporter signature motif; other site
278137006658	Walker B; other site
278137006659	D-loop; other site
278137006660	H-loop/switch region; other site
278137006661	TOBE domain; Region: TOBE_2; pfam08402
278137006662	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
278137006663	hydrophobic ligand binding site; other site
278137006664	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
278137006665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137006666	TspO/MBR family; Region: TspO_MBR; pfam03073
278137006667	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
278137006668	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
278137006669	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
278137006670	FAD binding pocket [chemical binding]; other site
278137006671	FAD binding motif [chemical binding]; other site
278137006672	phosphate binding motif [ion binding]; other site
278137006673	NAD binding pocket [chemical binding]; other site
278137006674	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137006675	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
278137006676	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137006677	NAD binding site [chemical binding]; other site
278137006678	catalytic Zn binding site [ion binding]; other site
278137006679	structural Zn binding site [ion binding]; other site
278137006680	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
278137006681	hydrophobic ligand binding site; other site
278137006682	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
278137006683	amidase catalytic site [active]
278137006684	Zn binding residues [ion binding]; other site
278137006685	substrate binding site [chemical binding]; other site
278137006686	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
278137006687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137006688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137006689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137006690	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
278137006691	NAD(P) binding site [chemical binding]; other site
278137006692	active site
278137006693	Ecdysteroid kinase; Region: EcKinase; cl17738
278137006694	Phosphotransferase enzyme family; Region: APH; pfam01636
278137006695	Ferredoxin [Energy production and conversion]; Region: COG1146
278137006696	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
278137006697	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
278137006698	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
278137006699	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
278137006700	Walker A/P-loop; other site
278137006701	ATP binding site [chemical binding]; other site
278137006702	Q-loop/lid; other site
278137006703	ABC transporter signature motif; other site
278137006704	Walker B; other site
278137006705	D-loop; other site
278137006706	H-loop/switch region; other site
278137006707	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
278137006708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137006709	dimer interface [polypeptide binding]; other site
278137006710	conserved gate region; other site
278137006711	putative PBP binding loops; other site
278137006712	ABC-ATPase subunit interface; other site
278137006713	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
278137006714	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137006715	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
278137006716	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137006717	dimerization interface [polypeptide binding]; other site
278137006718	putative DNA binding site [nucleotide binding]; other site
278137006719	putative Zn2+ binding site [ion binding]; other site
278137006720	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137006721	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137006722	NAD(P) binding site [chemical binding]; other site
278137006723	active site
278137006724	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137006725	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137006726	substrate binding pocket [chemical binding]; other site
278137006727	membrane-bound complex binding site; other site
278137006728	hinge residues; other site
278137006729	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
278137006730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137006731	dimer interface [polypeptide binding]; other site
278137006732	conserved gate region; other site
278137006733	putative PBP binding loops; other site
278137006734	ABC-ATPase subunit interface; other site
278137006735	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
278137006736	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
278137006737	Walker A/P-loop; other site
278137006738	ATP binding site [chemical binding]; other site
278137006739	Q-loop/lid; other site
278137006740	ABC transporter signature motif; other site
278137006741	Walker B; other site
278137006742	D-loop; other site
278137006743	H-loop/switch region; other site
278137006744	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
278137006745	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
278137006746	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
278137006747	ABC-ATPase subunit  interface; other site
278137006748	dimer interface [polypeptide binding]; other site
278137006749	putative PBP binding regions; other site
278137006750	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
278137006751	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
278137006752	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
278137006753	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
278137006754	metal binding site [ion binding]; metal-binding site
278137006755	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
278137006756	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
278137006757	Na binding site [ion binding]; other site
278137006758	putative substrate binding site [chemical binding]; other site
278137006759	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
278137006760	hypothetical protein; Provisional; Region: PRK11171
278137006761	Cupin domain; Region: Cupin_2; pfam07883
278137006762	Cupin domain; Region: Cupin_2; cl17218
278137006763	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
278137006764	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
278137006765	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137006766	Bacterial transcriptional regulator; Region: IclR; pfam01614
278137006767	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
278137006768	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
278137006769	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137006770	catalytic residue [active]
278137006771	Cutinase; Region: Cutinase; pfam01083
278137006772	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137006773	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137006774	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
278137006775	Cadmium resistance transporter; Region: Cad; pfam03596
278137006776	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
278137006777	Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043
278137006778	DNA binding residues [nucleotide binding]
278137006779	dimer interface [polypeptide binding]; other site
278137006780	metal binding site [ion binding]; metal-binding site
278137006781	mercuric reductase; Region: MerA; TIGR02053
278137006782	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137006783	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
278137006784	alkylmercury lyase; Provisional; Region: PRK13239
278137006785	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
278137006786	Alkylmercury lyase; Region: MerB; pfam03243
278137006787	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
278137006788	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
278137006789	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
278137006790	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
278137006791	AAA domain; Region: AAA_22; pfam13401
278137006792	ATP-binding site [chemical binding]; other site
278137006793	Helix-turn-helix domain; Region: HTH_28; pfam13518
278137006794	Winged helix-turn helix; Region: HTH_29; pfam13551
278137006795	Homeodomain-like domain; Region: HTH_32; pfam13565
278137006796	Integrase core domain; Region: rve; pfam00665
278137006797	Integrase core domain; Region: rve_3; pfam13683
278137006798	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
278137006799	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137006800	Integrase core domain; Region: rve; pfam00665
278137006801	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
278137006802	putative transposase OrfB; Reviewed; Region: PHA02517
278137006803	Integrase core domain; Region: rve; pfam00665
278137006804	Integrase core domain; Region: rve_3; pfam13683
278137006805	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137006806	Transposase; Region: HTH_Tnp_1; pfam01527
278137006807	putative transposase OrfB; Reviewed; Region: PHA02517
278137006808	HTH-like domain; Region: HTH_21; pfam13276
278137006809	Integrase core domain; Region: rve; pfam00665
278137006810	Integrase core domain; Region: rve_3; pfam13683
278137006811	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137006812	Transposase; Region: HTH_Tnp_1; cl17663
278137006813	Integrase core domain; Region: rve; pfam00665
278137006814	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
278137006815	AAA domain; Region: AAA_22; pfam13401
278137006816	Bacterial TniB protein; Region: TniB; pfam05621
278137006817	TniQ; Region: TniQ; pfam06527
278137006818	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
278137006819	Cadmium resistance transporter; Region: Cad; pfam03596
278137006820	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
278137006821	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137006822	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137006823	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137006824	dimerization interface [polypeptide binding]; other site
278137006825	putative DNA binding site [nucleotide binding]; other site
278137006826	putative Zn2+ binding site [ion binding]; other site
278137006827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137006828	Transposase; Region: HTH_Tnp_1; pfam01527
278137006829	HTH-like domain; Region: HTH_21; pfam13276
278137006830	Integrase core domain; Region: rve; pfam00665
278137006831	Integrase core domain; Region: rve_3; pfam13683
278137006832	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137006833	HTH-like domain; Region: HTH_21; pfam13276
278137006834	Integrase core domain; Region: rve; pfam00665
278137006835	Integrase core domain; Region: rve_3; pfam13683
278137006836	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137006837	Transposase; Region: HTH_Tnp_1; pfam01527
278137006838	HTH-like domain; Region: HTH_21; pfam13276
278137006839	Integrase core domain; Region: rve; pfam00665
278137006840	Integrase core domain; Region: rve_3; pfam13683
278137006841	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137006842	Transposase; Region: HTH_Tnp_1; pfam01527
278137006843	putative transposase OrfB; Reviewed; Region: PHA02517
278137006844	HTH-like domain; Region: HTH_21; pfam13276
278137006845	Integrase core domain; Region: rve; pfam00665
278137006846	Integrase core domain; Region: rve_3; pfam13683
278137006847	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137006848	Transposase; Region: HTH_Tnp_1; pfam01527
278137006849	putative transposase OrfB; Reviewed; Region: PHA02517
278137006850	HTH-like domain; Region: HTH_21; pfam13276
278137006851	Integrase core domain; Region: rve; pfam00665
278137006852	Integrase core domain; Region: rve_3; pfam13683
278137006853	cyclase homology domain; Region: CHD; cd07302
278137006854	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137006855	nucleotidyl binding site; other site
278137006856	metal binding site [ion binding]; metal-binding site
278137006857	dimer interface [polypeptide binding]; other site
278137006858	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137006859	cyclase homology domain; Region: CHD; cd07302
278137006860	nucleotidyl binding site; other site
278137006861	metal binding site [ion binding]; metal-binding site
278137006862	dimer interface [polypeptide binding]; other site
278137006863	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137006864	DNA binding site [nucleotide binding]
278137006865	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
278137006866	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
278137006867	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137006868	active site
278137006869	DNA binding site [nucleotide binding]
278137006870	Int/Topo IB signature motif; other site
278137006871	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
278137006872	Integrase core domain; Region: rve; pfam00665
278137006873	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
278137006874	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
278137006875	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137006876	ATP binding site [chemical binding]; other site
278137006877	putative Mg++ binding site [ion binding]; other site
278137006878	HsdM N-terminal domain; Region: HsdM_N; pfam12161
278137006879	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
278137006880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137006881	S-adenosylmethionine binding site [chemical binding]; other site
278137006882	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
278137006883	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
278137006884	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
278137006885	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
278137006886	active site
278137006887	NTP binding site [chemical binding]; other site
278137006888	metal binding triad [ion binding]; metal-binding site
278137006889	Transposase; Region: HTH_Tnp_1; pfam01527
278137006890	HTH-like domain; Region: HTH_21; pfam13276
278137006891	Integrase core domain; Region: rve; pfam00665
278137006892	Integrase core domain; Region: rve_3; pfam13683
278137006893	HTH-like domain; Region: HTH_21; pfam13276
278137006894	Integrase core domain; Region: rve; pfam00665
278137006895	Integrase core domain; Region: rve_3; pfam13683
278137006896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137006897	Transposase; Region: HTH_Tnp_1; pfam01527
278137006898	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
278137006899	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137006900	MULE transposase domain; Region: MULE; pfam10551
278137006901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137006902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137006903	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137006904	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
278137006905	YaeQ protein; Region: YaeQ; pfam07152
278137006906	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
278137006907	putative hydrophobic ligand binding site [chemical binding]; other site
278137006908	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137006909	dimerization interface [polypeptide binding]; other site
278137006910	putative DNA binding site [nucleotide binding]; other site
278137006911	putative Zn2+ binding site [ion binding]; other site
278137006912	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
278137006913	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137006914	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137006915	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137006916	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
278137006917	RNA binding surface [nucleotide binding]; other site
278137006918	Predicted esterase [General function prediction only]; Region: COG0627
278137006919	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
278137006920	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
278137006921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137006922	S-adenosylmethionine binding site [chemical binding]; other site
278137006923	Protein of unknown function (DUF664); Region: DUF664; pfam04978
278137006924	DinB superfamily; Region: DinB_2; pfam12867
278137006925	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
278137006926	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137006927	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137006928	acyl-activating enzyme (AAE) consensus motif; other site
278137006929	acyl-activating enzyme (AAE) consensus motif; other site
278137006930	AMP binding site [chemical binding]; other site
278137006931	active site
278137006932	CoA binding site [chemical binding]; other site
278137006933	probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854
278137006934	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137006935	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137006936	Uncharacterized conserved protein [Function unknown]; Region: COG1434
278137006937	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
278137006938	putative active site [active]
278137006939	PE-PPE domain; Region: PE-PPE; pfam08237
278137006940	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137006941	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137006942	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
278137006943	dimer interface [polypeptide binding]; other site
278137006944	catalytic triad [active]
278137006945	peroxidatic and resolving cysteines [active]
278137006946	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
278137006947	Putative transcription activator [Transcription]; Region: TenA; COG0819
278137006948	hypothetical protein; Validated; Region: PRK07198
278137006949	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
278137006950	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
278137006951	dimerization interface [polypeptide binding]; other site
278137006952	active site
278137006953	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
278137006954	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137006955	active site
278137006956	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
278137006957	tetramer interface [polypeptide binding]; other site
278137006958	active site
278137006959	Mg2+/Mn2+ binding site [ion binding]; other site
278137006960	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
278137006961	O-succinylbenzoate synthase; Provisional; Region: PRK02901
278137006962	O-succinylbenzoate synthase; Provisional; Region: PRK02901
278137006963	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
278137006964	catalytic triad [active]
278137006965	Arterivirus envelope protein; Region: Arteri_env; pfam01606
278137006966	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
278137006967	apolar tunnel; other site
278137006968	heme binding site [chemical binding]; other site
278137006969	dimerization interface [polypeptide binding]; other site
278137006970	Stress responsive A/B Barrel Domain; Region: Dabb; cl17744
278137006971	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
278137006972	active site
278137006973	catalytic triad [active]
278137006974	oxyanion hole [active]
278137006975	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137006976	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
278137006977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137006978	active site
278137006979	phosphorylation site [posttranslational modification]
278137006980	intermolecular recognition site; other site
278137006981	dimerization interface [polypeptide binding]; other site
278137006982	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
278137006983	CHASE3 domain; Region: CHASE3; pfam05227
278137006984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137006985	dimer interface [polypeptide binding]; other site
278137006986	phosphorylation site [posttranslational modification]
278137006987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137006988	ATP binding site [chemical binding]; other site
278137006989	Mg2+ binding site [ion binding]; other site
278137006990	G-X-G motif; other site
278137006991	Response regulator receiver domain; Region: Response_reg; pfam00072
278137006992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137006993	active site
278137006994	phosphorylation site [posttranslational modification]
278137006995	intermolecular recognition site; other site
278137006996	dimerization interface [polypeptide binding]; other site
278137006997	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
278137006998	NlpC/P60 family; Region: NLPC_P60; cl17555
278137006999	hypothetical protein; Validated; Region: PRK02101
278137007000	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137007001	competence damage-inducible protein A; Provisional; Region: PRK00549
278137007002	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
278137007003	Competence-damaged protein; Region: CinA; pfam02464
278137007004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137007005	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137007006	NAD(P) binding site [chemical binding]; other site
278137007007	active site
278137007008	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137007009	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
278137007010	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
278137007011	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137007012	anti sigma factor interaction site; other site
278137007013	regulatory phosphorylation site [posttranslational modification]; other site
278137007014	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
278137007015	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
278137007016	Nitronate monooxygenase; Region: NMO; pfam03060
278137007017	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137007018	FMN binding site [chemical binding]; other site
278137007019	substrate binding site [chemical binding]; other site
278137007020	putative catalytic residue [active]
278137007021	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137007022	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137007023	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
278137007024	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137007025	molybdopterin cofactor binding site; other site
278137007026	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137007027	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
278137007028	molybdopterin cofactor binding site; other site
278137007029	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137007030	Cytochrome P450; Region: p450; cl12078
278137007031	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137007032	sequence-specific DNA binding site [nucleotide binding]; other site
278137007033	salt bridge; other site
278137007034	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
278137007035	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137007036	CoA binding site [chemical binding]; other site
278137007037	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
278137007038	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
278137007039	substrate binding site; other site
278137007040	tetramer interface; other site
278137007041	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
278137007042	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
278137007043	NAD binding site [chemical binding]; other site
278137007044	substrate binding site [chemical binding]; other site
278137007045	homodimer interface [polypeptide binding]; other site
278137007046	active site
278137007047	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
278137007048	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
278137007049	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
278137007050	NADP binding site [chemical binding]; other site
278137007051	active site
278137007052	putative substrate binding site [chemical binding]; other site
278137007053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137007054	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137007055	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137007056	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
278137007057	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
278137007058	tetramer interface [polypeptide binding]; other site
278137007059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137007060	catalytic residue [active]
278137007061	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
278137007062	active site
278137007063	agmatinase; Region: agmatinase; TIGR01230
278137007064	Agmatinase-like family; Region: Agmatinase-like; cd09990
278137007065	active site
278137007066	oligomer interface [polypeptide binding]; other site
278137007067	Mn binding site [ion binding]; other site
278137007068	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
278137007069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137007070	S-adenosylmethionine binding site [chemical binding]; other site
278137007071	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137007072	Cytochrome P450; Region: p450; cl12078
278137007073	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137007074	MULE transposase domain; Region: MULE; pfam10551
278137007075	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137007076	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
278137007077	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
278137007078	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
278137007079	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137007080	active site
278137007081	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137007082	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137007083	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
278137007084	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
278137007085	active site
278137007086	putative substrate binding pocket [chemical binding]; other site
278137007087	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137007088	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
278137007089	putative hydrophobic ligand binding site [chemical binding]; other site
278137007090	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137007091	dimerization interface [polypeptide binding]; other site
278137007092	putative DNA binding site [nucleotide binding]; other site
278137007093	putative Zn2+ binding site [ion binding]; other site
278137007094	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137007095	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
278137007096	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
278137007097	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
278137007098	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137007099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137007100	putative substrate translocation pore; other site
278137007101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137007102	putative substrate translocation pore; other site
278137007103	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
278137007104	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
278137007105	heme binding site [chemical binding]; other site
278137007106	ferroxidase pore; other site
278137007107	ferroxidase diiron center [ion binding]; other site
278137007108	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
278137007109	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137007110	substrate binding site [chemical binding]; other site
278137007111	oxyanion hole (OAH) forming residues; other site
278137007112	trimer interface [polypeptide binding]; other site
278137007113	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
278137007114	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137007115	CoenzymeA binding site [chemical binding]; other site
278137007116	subunit interaction site [polypeptide binding]; other site
278137007117	PHB binding site; other site
278137007118	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137007119	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137007120	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
278137007121	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
278137007122	binding surface
278137007123	TPR motif; other site
278137007124	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
278137007125	nucleoside/Zn binding site; other site
278137007126	dimer interface [polypeptide binding]; other site
278137007127	catalytic motif [active]
278137007128	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
278137007129	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
278137007130	active site
278137007131	catalytic site [active]
278137007132	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
278137007133	Putative esterase; Region: Esterase; pfam00756
278137007134	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
278137007135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137007136	Walker A motif; other site
278137007137	ATP binding site [chemical binding]; other site
278137007138	Walker B motif; other site
278137007139	arginine finger; other site
278137007140	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
278137007141	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
278137007142	minor groove reading motif; other site
278137007143	helix-hairpin-helix signature motif; other site
278137007144	malate dehydrogenase; Provisional; Region: PRK05442
278137007145	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
278137007146	NAD(P) binding site [chemical binding]; other site
278137007147	LDH/MDH dimer interface [polypeptide binding]; other site
278137007148	substrate binding site [chemical binding]; other site
278137007149	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
278137007150	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137007151	active site
278137007152	putative phosphoketolase; Provisional; Region: PRK05261
278137007153	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
278137007154	TPP-binding site; other site
278137007155	Src Homology 3 domain superfamily; Region: SH3; cl17036
278137007156	peptide ligand binding site [polypeptide binding]; other site
278137007157	XFP C-terminal domain; Region: XFP_C; pfam09363
278137007158	CAAX protease self-immunity; Region: Abi; pfam02517
278137007159	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
278137007160	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
278137007161	putative NAD(P) binding site [chemical binding]; other site
278137007162	putative substrate binding site [chemical binding]; other site
278137007163	catalytic Zn binding site [ion binding]; other site
278137007164	structural Zn binding site [ion binding]; other site
278137007165	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
278137007166	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
278137007167	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
278137007168	classical (c) SDRs; Region: SDR_c; cd05233
278137007169	NAD(P) binding site [chemical binding]; other site
278137007170	active site
278137007171	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137007172	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
278137007173	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
278137007174	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137007175	UreD urease accessory protein; Region: UreD; cl00530
278137007176	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
278137007177	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
278137007178	urease subunit alpha; Reviewed; Region: ureC; PRK13206
278137007179	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
278137007180	subunit interactions [polypeptide binding]; other site
278137007181	active site
278137007182	flap region; other site
278137007183	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
278137007184	gamma-beta subunit interface [polypeptide binding]; other site
278137007185	alpha-beta subunit interface [polypeptide binding]; other site
278137007186	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
278137007187	alpha-gamma subunit interface [polypeptide binding]; other site
278137007188	beta-gamma subunit interface [polypeptide binding]; other site
278137007189	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137007190	CoenzymeA binding site [chemical binding]; other site
278137007191	subunit interaction site [polypeptide binding]; other site
278137007192	PHB binding site; other site
278137007193	Predicted transcriptional regulator [Transcription]; Region: COG3682
278137007194	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
278137007195	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
278137007196	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
278137007197	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
278137007198	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
278137007199	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
278137007200	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
278137007201	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
278137007202	active site
278137007203	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
278137007204	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
278137007205	Walker A/P-loop; other site
278137007206	ATP binding site [chemical binding]; other site
278137007207	Q-loop/lid; other site
278137007208	ABC transporter signature motif; other site
278137007209	Walker B; other site
278137007210	D-loop; other site
278137007211	H-loop/switch region; other site
278137007212	TOBE domain; Region: TOBE_2; pfam08402
278137007213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137007214	dimer interface [polypeptide binding]; other site
278137007215	conserved gate region; other site
278137007216	ABC-ATPase subunit interface; other site
278137007217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137007218	dimer interface [polypeptide binding]; other site
278137007219	conserved gate region; other site
278137007220	putative PBP binding loops; other site
278137007221	ABC-ATPase subunit interface; other site
278137007222	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
278137007223	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
278137007224	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
278137007225	Domain of unknown function DUF21; Region: DUF21; pfam01595
278137007226	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
278137007227	Transporter associated domain; Region: CorC_HlyC; smart01091
278137007228	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
278137007229	Domain of unknown function DUF21; Region: DUF21; pfam01595
278137007230	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
278137007231	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
278137007232	active site
278137007233	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
278137007234	metal ion-dependent adhesion site (MIDAS); other site
278137007235	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
278137007236	Fatty acid desaturase; Region: FA_desaturase; pfam00487
278137007237	Di-iron ligands [ion binding]; other site
278137007238	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
278137007239	classical (c) SDRs; Region: SDR_c; cd05233
278137007240	NAD(P) binding site [chemical binding]; other site
278137007241	active site
278137007242	PE-PPE domain; Region: PE-PPE; pfam08237
278137007243	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137007244	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137007245	Cutinase; Region: Cutinase; pfam01083
278137007246	PE-PPE domain; Region: PE-PPE; pfam08237
278137007247	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137007248	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
278137007249	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137007250	Cytochrome P450; Region: p450; cl12078
278137007251	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137007252	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137007253	PE-PPE domain; Region: PE-PPE; pfam08237
278137007254	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137007255	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137007256	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
278137007257	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137007258	Nitroreductase family; Region: Nitroreductase; pfam00881
278137007259	FMN binding site [chemical binding]; other site
278137007260	dimer interface [polypeptide binding]; other site
278137007261	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
278137007262	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
278137007263	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
278137007264	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137007265	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
278137007266	acyltransferase PapA5; Provisional; Region: PRK09294
278137007267	ABC-2 type transporter; Region: ABC2_membrane; cl17235
278137007268	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
278137007269	ABC-2 type transporter; Region: ABC2_membrane; cl17235
278137007270	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
278137007271	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137007272	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
278137007273	Walker A/P-loop; other site
278137007274	ATP binding site [chemical binding]; other site
278137007275	Q-loop/lid; other site
278137007276	ABC transporter signature motif; other site
278137007277	Walker B; other site
278137007278	D-loop; other site
278137007279	H-loop/switch region; other site
278137007280	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
278137007281	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137007282	active site
278137007283	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
278137007284	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137007285	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137007286	Condensation domain; Region: Condensation; pfam00668
278137007287	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
278137007288	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
278137007289	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137007290	active site
278137007291	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137007292	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
278137007293	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
278137007294	KR domain; Region: KR; pfam08659
278137007295	putative NADP binding site [chemical binding]; other site
278137007296	active site
278137007297	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137007298	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
278137007299	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137007300	active site
278137007301	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137007302	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
278137007303	KR domain; Region: KR; pfam08659
278137007304	putative NADP binding site [chemical binding]; other site
278137007305	active site
278137007306	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
278137007307	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137007308	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137007309	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137007310	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
278137007311	active site
278137007312	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
278137007313	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137007314	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
278137007315	KR domain; Region: KR; pfam08659
278137007316	NADP binding site [chemical binding]; other site
278137007317	active site
278137007318	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137007319	acyl-CoA synthetase; Validated; Region: PRK05850
278137007320	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
278137007321	acyl-activating enzyme (AAE) consensus motif; other site
278137007322	active site
278137007323	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137007324	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137007325	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
278137007326	active site
278137007327	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
278137007328	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137007329	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
278137007330	putative NADP binding site [chemical binding]; other site
278137007331	KR domain; Region: KR; pfam08659
278137007332	active site
278137007333	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137007334	acyl-CoA synthetase; Validated; Region: PRK05850
278137007335	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
278137007336	acyl-activating enzyme (AAE) consensus motif; other site
278137007337	active site
278137007338	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
278137007339	glycine dehydrogenase; Provisional; Region: PRK05367
278137007340	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
278137007341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137007342	tetramer interface [polypeptide binding]; other site
278137007343	catalytic residue [active]
278137007344	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
278137007345	tetramer interface [polypeptide binding]; other site
278137007346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137007347	catalytic residue [active]
278137007348	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
278137007349	DNA binding residues [nucleotide binding]
278137007350	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
278137007351	putative dimer interface [polypeptide binding]; other site
278137007352	Bifunctional nuclease; Region: DNase-RNase; pfam02577
278137007353	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
278137007354	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
278137007355	DNA binding residues [nucleotide binding]
278137007356	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
278137007357	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
278137007358	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
278137007359	phosphopeptide binding site; other site
278137007360	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
278137007361	lipoyl attachment site [posttranslational modification]; other site
278137007362	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
278137007363	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
278137007364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
278137007365	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
278137007366	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
278137007367	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
278137007368	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
278137007369	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
278137007370	nucleotide binding region [chemical binding]; other site
278137007371	ATP-binding site [chemical binding]; other site
278137007372	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
278137007373	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
278137007374	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
278137007375	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
278137007376	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
278137007377	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
278137007378	hypothetical protein; Validated; Region: PRK07121
278137007379	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
278137007380	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
278137007381	substrate binding site [chemical binding]; other site
278137007382	dimer interface [polypeptide binding]; other site
278137007383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137007384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137007385	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
278137007386	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
278137007387	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
278137007388	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
278137007389	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
278137007390	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137007391	substrate binding pocket [chemical binding]; other site
278137007392	catalytic triad [active]
278137007393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137007394	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137007395	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
278137007396	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
278137007397	putative transposase OrfB; Reviewed; Region: PHA02517
278137007398	HTH-like domain; Region: HTH_21; pfam13276
278137007399	Integrase core domain; Region: rve; pfam00665
278137007400	Integrase core domain; Region: rve_3; pfam13683
278137007401	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137007402	Transposase; Region: HTH_Tnp_1; pfam01527
278137007403	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137007404	Transposase; Region: HTH_Tnp_1; cl17663
278137007405	putative transposase OrfB; Reviewed; Region: PHA02517
278137007406	HTH-like domain; Region: HTH_21; pfam13276
278137007407	Integrase core domain; Region: rve; pfam00665
278137007408	Integrase core domain; Region: rve_3; pfam13683
278137007409	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
278137007410	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
278137007411	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
278137007412	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
278137007413	FMN-binding pocket [chemical binding]; other site
278137007414	flavin binding motif; other site
278137007415	phosphate binding motif [ion binding]; other site
278137007416	beta-alpha-beta structure motif; other site
278137007417	NAD binding pocket [chemical binding]; other site
278137007418	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137007419	catalytic loop [active]
278137007420	iron binding site [ion binding]; other site
278137007421	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137007422	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137007423	active site
278137007424	ATP binding site [chemical binding]; other site
278137007425	substrate binding site [chemical binding]; other site
278137007426	activation loop (A-loop); other site
278137007427	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137007428	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
278137007429	nudix motif; other site
278137007430	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
278137007431	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137007432	Cytochrome P450; Region: p450; cl12078
278137007433	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
278137007434	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137007435	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137007436	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
278137007437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137007438	D-galactonate transporter; Region: 2A0114; TIGR00893
278137007439	putative substrate translocation pore; other site
278137007440	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137007441	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137007442	active site
278137007443	ethanolamine permease; Region: 2A0305; TIGR00908
278137007444	PknH-like extracellular domain; Region: PknH_C; pfam14032
278137007445	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
278137007446	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
278137007447	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
278137007448	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
278137007449	RNA binding site [nucleotide binding]; other site
278137007450	thiamine pyrophosphate protein; Provisional; Region: PRK08273
278137007451	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
278137007452	PYR/PP interface [polypeptide binding]; other site
278137007453	dimer interface [polypeptide binding]; other site
278137007454	tetramer interface [polypeptide binding]; other site
278137007455	TPP binding site [chemical binding]; other site
278137007456	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
278137007457	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
278137007458	TPP-binding site [chemical binding]; other site
278137007459	hydroperoxidase II; Provisional; Region: katE; PRK11249
278137007460	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
278137007461	heme binding pocket [chemical binding]; other site
278137007462	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
278137007463	domain interactions; other site
278137007464	PAS fold; Region: PAS_3; pfam08447
278137007465	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
278137007466	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
278137007467	PhoU domain; Region: PhoU; pfam01895
278137007468	PhoU domain; Region: PhoU; pfam01895
278137007469	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137007470	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137007471	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
278137007472	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
278137007473	heme binding site [chemical binding]; other site
278137007474	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
278137007475	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
278137007476	metal binding site 2 [ion binding]; metal-binding site
278137007477	putative DNA binding helix; other site
278137007478	metal binding site 1 [ion binding]; metal-binding site
278137007479	dimer interface [polypeptide binding]; other site
278137007480	structural Zn2+ binding site [ion binding]; other site
278137007481	Acyltransferase family; Region: Acyl_transf_3; pfam01757
278137007482	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
278137007483	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
278137007484	Sulfatase; Region: Sulfatase; cl17466
278137007485	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
278137007486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137007487	Methyltransferase domain; Region: Methyltransf_11; pfam08241
278137007488	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
278137007489	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
278137007490	FAD binding site [chemical binding]; other site
278137007491	Cobalt transport protein; Region: CbiQ; cl00463
278137007492	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
278137007493	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
278137007494	Walker A/P-loop; other site
278137007495	ATP binding site [chemical binding]; other site
278137007496	Q-loop/lid; other site
278137007497	ABC transporter signature motif; other site
278137007498	Walker B; other site
278137007499	D-loop; other site
278137007500	H-loop/switch region; other site
278137007501	BioY family; Region: BioY; pfam02632
278137007502	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137007503	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137007504	short chain dehydrogenase; Provisional; Region: PRK05866
278137007505	classical (c) SDRs; Region: SDR_c; cd05233
278137007506	NAD(P) binding site [chemical binding]; other site
278137007507	active site
278137007508	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
278137007509	EamA-like transporter family; Region: EamA; pfam00892
278137007510	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
278137007511	Low molecular weight phosphatase family; Region: LMWPc; cl00105
278137007512	active site
278137007513	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
278137007514	arsenical-resistance protein; Region: acr3; TIGR00832
278137007515	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
278137007516	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137007517	putative metal binding site [ion binding]; other site
278137007518	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137007519	dimerization interface [polypeptide binding]; other site
278137007520	putative DNA binding site [nucleotide binding]; other site
278137007521	putative Zn2+ binding site [ion binding]; other site
278137007522	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137007523	Beta-lactamase; Region: Beta-lactamase; pfam00144
278137007524	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
278137007525	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137007526	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137007527	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137007528	Cytochrome P450; Region: p450; cl12078
278137007529	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137007530	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137007531	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137007532	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137007533	active site
278137007534	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137007535	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137007536	metal binding site [ion binding]; metal-binding site
278137007537	active site
278137007538	I-site; other site
278137007539	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137007540	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137007541	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
278137007542	NAD(P) binding site [chemical binding]; other site
278137007543	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
278137007544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137007545	tropinone reductase; Provisional; Region: PRK09242
278137007546	NAD(P) binding site [chemical binding]; other site
278137007547	active site
278137007548	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137007549	classical (c) SDRs; Region: SDR_c; cd05233
278137007550	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
278137007551	NAD(P) binding site [chemical binding]; other site
278137007552	active site
278137007553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
278137007554	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137007555	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
278137007556	Predicted transcriptional regulator [Transcription]; Region: COG2345
278137007557	Helix-turn-helix domain; Region: HTH_20; pfam12840
278137007558	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
278137007559	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
278137007560	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
278137007561	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
278137007562	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
278137007563	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
278137007564	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
278137007565	GTP-binding protein Der; Reviewed; Region: PRK03003
278137007566	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
278137007567	G1 box; other site
278137007568	GTP/Mg2+ binding site [chemical binding]; other site
278137007569	Switch I region; other site
278137007570	G2 box; other site
278137007571	Switch II region; other site
278137007572	G3 box; other site
278137007573	G4 box; other site
278137007574	G5 box; other site
278137007575	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
278137007576	G1 box; other site
278137007577	GTP/Mg2+ binding site [chemical binding]; other site
278137007578	Switch I region; other site
278137007579	G2 box; other site
278137007580	G3 box; other site
278137007581	Switch II region; other site
278137007582	G4 box; other site
278137007583	G5 box; other site
278137007584	cytidylate kinase; Provisional; Region: cmk; PRK00023
278137007585	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
278137007586	active site
278137007587	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
278137007588	CMP-binding site; other site
278137007589	The sites determining sugar specificity; other site
278137007590	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
278137007591	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
278137007592	RNA binding surface [nucleotide binding]; other site
278137007593	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
278137007594	active site
278137007595	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
278137007596	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
278137007597	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
278137007598	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137007599	P-loop; other site
278137007600	Magnesium ion binding site [ion binding]; other site
278137007601	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
278137007602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137007603	S-adenosylmethionine binding site [chemical binding]; other site
278137007604	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
278137007605	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137007606	active site
278137007607	DNA binding site [nucleotide binding]
278137007608	Int/Topo IB signature motif; other site
278137007609	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
278137007610	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
278137007611	dimer interface [polypeptide binding]; other site
278137007612	ADP-ribose binding site [chemical binding]; other site
278137007613	active site
278137007614	nudix motif; other site
278137007615	metal binding site [ion binding]; metal-binding site
278137007616	CTP synthetase; Validated; Region: pyrG; PRK05380
278137007617	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
278137007618	Catalytic site [active]
278137007619	active site
278137007620	UTP binding site [chemical binding]; other site
278137007621	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
278137007622	active site
278137007623	putative oxyanion hole; other site
278137007624	catalytic triad [active]
278137007625	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
278137007626	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
278137007627	Thiamine pyrophosphokinase; Region: TPK; cl08415
278137007628	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
278137007629	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
278137007630	active site
278137007631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137007632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137007633	DNA repair protein RecN; Region: recN; TIGR00634
278137007634	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
278137007635	Walker A/P-loop; other site
278137007636	ATP binding site [chemical binding]; other site
278137007637	Q-loop/lid; other site
278137007638	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
278137007639	ABC transporter signature motif; other site
278137007640	Walker B; other site
278137007641	D-loop; other site
278137007642	H-loop/switch region; other site
278137007643	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
278137007644	ATP-NAD kinase; Region: NAD_kinase; pfam01513
278137007645	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
278137007646	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
278137007647	RNA binding surface [nucleotide binding]; other site
278137007648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137007649	S-adenosylmethionine binding site [chemical binding]; other site
278137007650	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
278137007651	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137007652	active site
278137007653	motif I; other site
278137007654	motif II; other site
278137007655	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
278137007656	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
278137007657	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
278137007658	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
278137007659	active site
278137007660	HIGH motif; other site
278137007661	dimer interface [polypeptide binding]; other site
278137007662	KMSKS motif; other site
278137007663	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
278137007664	RNA binding surface [nucleotide binding]; other site
278137007665	3-methyladenine DNA glycosylase; Reviewed; Region: PRK00802
278137007666	Uncharacterized conserved protein [Function unknown]; Region: COG2835
278137007667	acyl-CoA synthetase; Validated; Region: PRK07868
278137007668	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
278137007669	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137007670	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137007671	active site
278137007672	CoA binding site [chemical binding]; other site
278137007673	AMP binding site [chemical binding]; other site
278137007674	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
278137007675	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
278137007676	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
278137007677	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
278137007678	argininosuccinate lyase; Provisional; Region: PRK00855
278137007679	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
278137007680	active sites [active]
278137007681	tetramer interface [polypeptide binding]; other site
278137007682	argininosuccinate synthase; Provisional; Region: PRK13820
278137007683	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
278137007684	ANP binding site [chemical binding]; other site
278137007685	Substrate Binding Site II [chemical binding]; other site
278137007686	Substrate Binding Site I [chemical binding]; other site
278137007687	Arginine repressor [Transcription]; Region: ArgR; COG1438
278137007688	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
278137007689	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
278137007690	ornithine carbamoyltransferase; Provisional; Region: PRK00779
278137007691	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
278137007692	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
278137007693	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
278137007694	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137007695	inhibitor-cofactor binding pocket; inhibition site
278137007696	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137007697	catalytic residue [active]
278137007698	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
278137007699	feedback inhibition sensing region; other site
278137007700	homohexameric interface [polypeptide binding]; other site
278137007701	nucleotide binding site [chemical binding]; other site
278137007702	N-acetyl-L-glutamate binding site [chemical binding]; other site
278137007703	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
278137007704	heterotetramer interface [polypeptide binding]; other site
278137007705	active site pocket [active]
278137007706	cleavage site
278137007707	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
278137007708	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
278137007709	Predicted dehydrogenase [General function prediction only]; Region: COG0579
278137007710	hydroxyglutarate oxidase; Provisional; Region: PRK11728
278137007711	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
278137007712	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
278137007713	putative tRNA-binding site [nucleotide binding]; other site
278137007714	B3/4 domain; Region: B3_4; pfam03483
278137007715	tRNA synthetase B5 domain; Region: B5; smart00874
278137007716	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
278137007717	dimer interface [polypeptide binding]; other site
278137007718	motif 1; other site
278137007719	motif 3; other site
278137007720	motif 2; other site
278137007721	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
278137007722	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
278137007723	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
278137007724	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
278137007725	dimer interface [polypeptide binding]; other site
278137007726	motif 1; other site
278137007727	active site
278137007728	motif 2; other site
278137007729	motif 3; other site
278137007730	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
278137007731	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137007732	cyclase homology domain; Region: CHD; cd07302
278137007733	nucleotidyl binding site; other site
278137007734	metal binding site [ion binding]; metal-binding site
278137007735	dimer interface [polypeptide binding]; other site
278137007736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
278137007737	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137007738	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137007739	active site
278137007740	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
278137007741	classical (c) SDRs; Region: SDR_c; cd05233
278137007742	NAD(P) binding site [chemical binding]; other site
278137007743	active site
278137007744	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
278137007745	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
278137007746	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
278137007747	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
278137007748	23S rRNA binding site [nucleotide binding]; other site
278137007749	L21 binding site [polypeptide binding]; other site
278137007750	L13 binding site [polypeptide binding]; other site
278137007751	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
278137007752	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
278137007753	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
278137007754	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
278137007755	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
278137007756	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
278137007757	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
278137007758	dimer interface [polypeptide binding]; other site
278137007759	putative anticodon binding site; other site
278137007760	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
278137007761	motif 1; other site
278137007762	dimer interface [polypeptide binding]; other site
278137007763	active site
278137007764	motif 2; other site
278137007765	motif 3; other site
278137007766	Predicted esterase [General function prediction only]; Region: COG0627
278137007767	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
278137007768	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
278137007769	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
278137007770	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
278137007771	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
278137007772	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
278137007773	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137007774	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
278137007775	catalytic residue [active]
278137007776	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137007777	Ligand Binding Site [chemical binding]; other site
278137007778	Cutinase; Region: Cutinase; pfam01083
278137007779	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
278137007780	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
278137007781	excinuclease ABC subunit B; Provisional; Region: PRK05298
278137007782	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137007783	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137007784	nucleotide binding region [chemical binding]; other site
278137007785	ATP-binding site [chemical binding]; other site
278137007786	Ultra-violet resistance protein B; Region: UvrB; pfam12344
278137007787	UvrB/uvrC motif; Region: UVR; pfam02151
278137007788	Protein of unknown function (DUF402); Region: DUF402; cl00979
278137007789	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
278137007790	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
278137007791	CoA-binding site [chemical binding]; other site
278137007792	ATP-binding [chemical binding]; other site
278137007793	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
278137007794	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
278137007795	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
278137007796	RNA binding site [nucleotide binding]; other site
278137007797	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
278137007798	RNA binding site [nucleotide binding]; other site
278137007799	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
278137007800	RNA binding site [nucleotide binding]; other site
278137007801	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
278137007802	RNA binding site [nucleotide binding]; other site
278137007803	Protease prsW family; Region: PrsW-protease; pfam13367
278137007804	DNA polymerase I; Provisional; Region: PRK05755
278137007805	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
278137007806	active site
278137007807	metal binding site 1 [ion binding]; metal-binding site
278137007808	putative 5' ssDNA interaction site; other site
278137007809	metal binding site 3; metal-binding site
278137007810	metal binding site 2 [ion binding]; metal-binding site
278137007811	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
278137007812	putative DNA binding site [nucleotide binding]; other site
278137007813	putative metal binding site [ion binding]; other site
278137007814	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
278137007815	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
278137007816	active site
278137007817	DNA binding site [nucleotide binding]
278137007818	catalytic site [active]
278137007819	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
278137007820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137007821	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
278137007822	putative dimerization interface [polypeptide binding]; other site
278137007823	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
278137007824	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137007825	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
278137007826	DUF35 OB-fold domain; Region: DUF35; pfam01796
278137007827	lipid-transfer protein; Provisional; Region: PRK06059
278137007828	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137007829	active site
278137007830	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
278137007831	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
278137007832	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
278137007833	Walker A/P-loop; other site
278137007834	ATP binding site [chemical binding]; other site
278137007835	Q-loop/lid; other site
278137007836	ABC transporter signature motif; other site
278137007837	Walker B; other site
278137007838	D-loop; other site
278137007839	H-loop/switch region; other site
278137007840	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
278137007841	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
278137007842	Walker A/P-loop; other site
278137007843	ATP binding site [chemical binding]; other site
278137007844	Q-loop/lid; other site
278137007845	ABC transporter signature motif; other site
278137007846	Walker B; other site
278137007847	D-loop; other site
278137007848	H-loop/switch region; other site
278137007849	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
278137007850	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
278137007851	TM-ABC transporter signature motif; other site
278137007852	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
278137007853	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
278137007854	TM-ABC transporter signature motif; other site
278137007855	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
278137007856	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
278137007857	dimerization interface [polypeptide binding]; other site
278137007858	ligand binding site [chemical binding]; other site
278137007859	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
278137007860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137007861	active site
278137007862	phosphorylation site [posttranslational modification]
278137007863	intermolecular recognition site; other site
278137007864	dimerization interface [polypeptide binding]; other site
278137007865	ANTAR domain; Region: ANTAR; pfam03861
278137007866	Heme NO binding associated; Region: HNOBA; pfam07701
278137007867	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
278137007868	cyclase homology domain; Region: CHD; cd07302
278137007869	nucleotidyl binding site; other site
278137007870	metal binding site [ion binding]; metal-binding site
278137007871	dimer interface [polypeptide binding]; other site
278137007872	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
278137007873	Ferritin-like domain; Region: Ferritin; pfam00210
278137007874	dimerization interface [polypeptide binding]; other site
278137007875	DPS ferroxidase diiron center [ion binding]; other site
278137007876	ion pore; other site
278137007877	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137007878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137007879	active site
278137007880	phosphorylation site [posttranslational modification]
278137007881	intermolecular recognition site; other site
278137007882	dimerization interface [polypeptide binding]; other site
278137007883	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137007884	DNA binding residues [nucleotide binding]
278137007885	dimerization interface [polypeptide binding]; other site
278137007886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
278137007887	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137007888	ATP binding site [chemical binding]; other site
278137007889	Mg2+ binding site [ion binding]; other site
278137007890	G-X-G motif; other site
278137007891	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
278137007892	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
278137007893	Walker A/P-loop; other site
278137007894	ATP binding site [chemical binding]; other site
278137007895	Q-loop/lid; other site
278137007896	ABC transporter signature motif; other site
278137007897	Walker B; other site
278137007898	D-loop; other site
278137007899	H-loop/switch region; other site
278137007900	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
278137007901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137007902	dimer interface [polypeptide binding]; other site
278137007903	conserved gate region; other site
278137007904	putative PBP binding loops; other site
278137007905	ABC-ATPase subunit interface; other site
278137007906	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137007907	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137007908	substrate binding pocket [chemical binding]; other site
278137007909	membrane-bound complex binding site; other site
278137007910	hinge residues; other site
278137007911	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
278137007912	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
278137007913	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
278137007914	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
278137007915	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
278137007916	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
278137007917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137007918	Walker A/P-loop; other site
278137007919	ATP binding site [chemical binding]; other site
278137007920	Q-loop/lid; other site
278137007921	ABC transporter signature motif; other site
278137007922	Walker B; other site
278137007923	D-loop; other site
278137007924	H-loop/switch region; other site
278137007925	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
278137007926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137007927	Walker A/P-loop; other site
278137007928	ATP binding site [chemical binding]; other site
278137007929	ABC transporter signature motif; other site
278137007930	Walker B; other site
278137007931	D-loop; other site
278137007932	H-loop/switch region; other site
278137007933	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
278137007934	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
278137007935	active site
278137007936	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
278137007937	catalytic triad [active]
278137007938	dimer interface [polypeptide binding]; other site
278137007939	pyruvate kinase; Provisional; Region: PRK06247
278137007940	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
278137007941	domain interfaces; other site
278137007942	active site
278137007943	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
278137007944	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137007945	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
278137007946	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
278137007947	active site
278137007948	dimer interface [polypeptide binding]; other site
278137007949	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
278137007950	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
278137007951	active site
278137007952	FMN binding site [chemical binding]; other site
278137007953	substrate binding site [chemical binding]; other site
278137007954	3Fe-4S cluster binding site [ion binding]; other site
278137007955	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
278137007956	domain interface; other site
278137007957	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
278137007958	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137007959	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137007960	active site
278137007961	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
278137007962	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
278137007963	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
278137007964	substrate binding site [chemical binding]; other site
278137007965	active site
278137007966	catalytic residues [active]
278137007967	heterodimer interface [polypeptide binding]; other site
278137007968	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
278137007969	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
278137007970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137007971	catalytic residue [active]
278137007972	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
278137007973	active site
278137007974	ribulose/triose binding site [chemical binding]; other site
278137007975	phosphate binding site [ion binding]; other site
278137007976	substrate (anthranilate) binding pocket [chemical binding]; other site
278137007977	product (indole) binding pocket [chemical binding]; other site
278137007978	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
278137007979	anthranilate synthase component I; Provisional; Region: PRK13571
278137007980	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
278137007981	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
278137007982	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
278137007983	catalytic triad [active]
278137007984	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
278137007985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137007986	Walker A/P-loop; other site
278137007987	ATP binding site [chemical binding]; other site
278137007988	Q-loop/lid; other site
278137007989	ABC transporter signature motif; other site
278137007990	Walker B; other site
278137007991	D-loop; other site
278137007992	H-loop/switch region; other site
278137007993	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
278137007994	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
278137007995	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
278137007996	substrate binding site [chemical binding]; other site
278137007997	glutamase interaction surface [polypeptide binding]; other site
278137007998	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
278137007999	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
278137008000	active site
278137008001	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
278137008002	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
278137008003	catalytic residues [active]
278137008004	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
278137008005	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
278137008006	putative active site [active]
278137008007	oxyanion strand; other site
278137008008	catalytic triad [active]
278137008009	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
278137008010	putative active site pocket [active]
278137008011	4-fold oligomerization interface [polypeptide binding]; other site
278137008012	metal binding residues [ion binding]; metal-binding site
278137008013	3-fold/trimer interface [polypeptide binding]; other site
278137008014	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
278137008015	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137008016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137008017	homodimer interface [polypeptide binding]; other site
278137008018	catalytic residue [active]
278137008019	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
278137008020	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
278137008021	NAD binding site [chemical binding]; other site
278137008022	dimerization interface [polypeptide binding]; other site
278137008023	product binding site; other site
278137008024	substrate binding site [chemical binding]; other site
278137008025	zinc binding site [ion binding]; other site
278137008026	catalytic residues [active]
278137008027	Domain of unknown function (DUF385); Region: DUF385; cl04387
278137008028	LysE type translocator; Region: LysE; cl00565
278137008029	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
278137008030	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
278137008031	dimerization interface [polypeptide binding]; other site
278137008032	active site
278137008033	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
278137008034	L-aspartate oxidase; Provisional; Region: PRK06175
278137008035	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
278137008036	quinolinate synthetase; Provisional; Region: PRK09375
278137008037	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
278137008038	nudix motif; other site
278137008039	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
278137008040	Secretory lipase; Region: LIP; pfam03583
278137008041	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
278137008042	biotin synthase; Validated; Region: PRK06256
278137008043	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137008044	FeS/SAM binding site; other site
278137008045	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
278137008046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137008047	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
278137008048	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
278137008049	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
278137008050	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
278137008051	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
278137008052	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137008053	catalytic residue [active]
278137008054	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
278137008055	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137008056	inhibitor-cofactor binding pocket; inhibition site
278137008057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137008058	catalytic residue [active]
278137008059	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137008060	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137008061	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
278137008062	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
278137008063	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
278137008064	active site
278137008065	catalytic site [active]
278137008066	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
278137008067	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
278137008068	active site
278137008069	catalytic site [active]
278137008070	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
278137008071	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
278137008072	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
278137008073	catalytic site [active]
278137008074	active site
278137008075	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
278137008076	threonine dehydratase; Validated; Region: PRK08639
278137008077	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
278137008078	tetramer interface [polypeptide binding]; other site
278137008079	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137008080	catalytic residue [active]
278137008081	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
278137008082	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
278137008083	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
278137008084	active site
278137008085	PHP Thumb interface [polypeptide binding]; other site
278137008086	metal binding site [ion binding]; metal-binding site
278137008087	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
278137008088	generic binding surface II; other site
278137008089	generic binding surface I; other site
278137008090	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137008091	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137008092	Predicted permeases [General function prediction only]; Region: RarD; COG2962
278137008093	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
278137008094	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
278137008095	active site
278137008096	lipoprotein signal peptidase; Provisional; Region: PRK14764
278137008097	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
278137008098	active site
278137008099	homotetramer interface [polypeptide binding]; other site
278137008100	homodimer interface [polypeptide binding]; other site
278137008101	DNA polymerase IV; Provisional; Region: PRK03348
278137008102	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
278137008103	active site
278137008104	DNA binding site [nucleotide binding]
278137008105	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
278137008106	RNA binding surface [nucleotide binding]; other site
278137008107	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
278137008108	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
278137008109	HIGH motif; other site
278137008110	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
278137008111	active site
278137008112	KMSKS motif; other site
278137008113	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
278137008114	tRNA binding surface [nucleotide binding]; other site
278137008115	anticodon binding site; other site
278137008116	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
278137008117	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
278137008118	Beta-lactamase; Region: Beta-lactamase; pfam00144
278137008119	membrane ATPase/protein kinase; Provisional; Region: PRK09435
278137008120	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
278137008121	Walker A; other site
278137008122	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
278137008123	G4 box; other site
278137008124	G5 box; other site
278137008125	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
278137008126	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
278137008127	active site
278137008128	substrate binding site [chemical binding]; other site
278137008129	coenzyme B12 binding site [chemical binding]; other site
278137008130	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
278137008131	B12 binding site [chemical binding]; other site
278137008132	cobalt ligand [ion binding]; other site
278137008133	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
278137008134	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
278137008135	heterodimer interface [polypeptide binding]; other site
278137008136	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
278137008137	Uncharacterized conserved protein [Function unknown]; Region: COG0398
278137008138	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
278137008139	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137008140	MULE transposase domain; Region: MULE; pfam10551
278137008141	DoxX-like family; Region: DoxX_2; pfam13564
278137008142	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
278137008143	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
278137008144	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
278137008145	ferrochelatase; Reviewed; Region: hemH; PRK00035
278137008146	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
278137008147	C-terminal domain interface [polypeptide binding]; other site
278137008148	active site
278137008149	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
278137008150	active site
278137008151	N-terminal domain interface [polypeptide binding]; other site
278137008152	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
278137008153	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
278137008154	NAD binding site [chemical binding]; other site
278137008155	homotetramer interface [polypeptide binding]; other site
278137008156	homodimer interface [polypeptide binding]; other site
278137008157	substrate binding site [chemical binding]; other site
278137008158	active site
278137008159	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
278137008160	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
278137008161	NAD(P) binding site [chemical binding]; other site
278137008162	homotetramer interface [polypeptide binding]; other site
278137008163	homodimer interface [polypeptide binding]; other site
278137008164	active site
278137008165	hypothetical protein; Provisional; Region: PRK13685
278137008166	Aerotolerance regulator N-terminal; Region: BatA; cl06567
278137008167	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
278137008168	metal ion-dependent adhesion site (MIDAS); other site
278137008169	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
278137008170	Protein of unknown function DUF58; Region: DUF58; pfam01882
278137008171	MoxR-like ATPases [General function prediction only]; Region: COG0714
278137008172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137008173	Walker A motif; other site
278137008174	ATP binding site [chemical binding]; other site
278137008175	Walker B motif; other site
278137008176	arginine finger; other site
278137008177	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137008178	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137008179	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137008180	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137008181	aconitate hydratase; Validated; Region: PRK09277
278137008182	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
278137008183	substrate binding site [chemical binding]; other site
278137008184	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
278137008185	ligand binding site [chemical binding]; other site
278137008186	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
278137008187	substrate binding site [chemical binding]; other site
278137008188	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137008189	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137008190	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
278137008191	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137008192	Walker A/P-loop; other site
278137008193	ATP binding site [chemical binding]; other site
278137008194	Q-loop/lid; other site
278137008195	ABC transporter signature motif; other site
278137008196	Walker B; other site
278137008197	D-loop; other site
278137008198	H-loop/switch region; other site
278137008199	ABC transporter; Region: ABC_tran_2; pfam12848
278137008200	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
278137008201	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
278137008202	catalytic residues [active]
278137008203	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
278137008204	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
278137008205	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
278137008206	trimerization site [polypeptide binding]; other site
278137008207	active site
278137008208	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
278137008209	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
278137008210	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137008211	catalytic residue [active]
278137008212	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
278137008213	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
278137008214	Walker A/P-loop; other site
278137008215	ATP binding site [chemical binding]; other site
278137008216	Q-loop/lid; other site
278137008217	ABC transporter signature motif; other site
278137008218	Walker B; other site
278137008219	D-loop; other site
278137008220	H-loop/switch region; other site
278137008221	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
278137008222	FeS assembly protein SufD; Region: sufD; TIGR01981
278137008223	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
278137008224	FeS assembly protein SufB; Region: sufB; TIGR01980
278137008225	Predicted transcriptional regulator [Transcription]; Region: COG2345
278137008226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137008227	dimerization interface [polypeptide binding]; other site
278137008228	putative DNA binding site [nucleotide binding]; other site
278137008229	putative Zn2+ binding site [ion binding]; other site
278137008230	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
278137008231	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
278137008232	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
278137008233	Walker A/P-loop; other site
278137008234	ATP binding site [chemical binding]; other site
278137008235	Q-loop/lid; other site
278137008236	ABC transporter signature motif; other site
278137008237	Walker B; other site
278137008238	D-loop; other site
278137008239	H-loop/switch region; other site
278137008240	ABC-2 type transporter; Region: ABC2_membrane; cl17235
278137008241	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137008242	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137008243	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
278137008244	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
278137008245	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
278137008246	ATP-grasp domain; Region: ATP-grasp_4; cl17255
278137008247	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
278137008248	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
278137008249	NADP binding site [chemical binding]; other site
278137008250	dimer interface [polypeptide binding]; other site
278137008251	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
278137008252	Uncharacterized conserved protein [Function unknown]; Region: COG5361
278137008253	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
278137008254	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
278137008255	UbiA prenyltransferase family; Region: UbiA; pfam01040
278137008256	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
278137008257	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
278137008258	TPP-binding site [chemical binding]; other site
278137008259	dimer interface [polypeptide binding]; other site
278137008260	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
278137008261	PYR/PP interface [polypeptide binding]; other site
278137008262	dimer interface [polypeptide binding]; other site
278137008263	TPP binding site [chemical binding]; other site
278137008264	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
278137008265	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
278137008266	putative active site [active]
278137008267	transaldolase; Provisional; Region: PRK03903
278137008268	catalytic residue [active]
278137008269	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
278137008270	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
278137008271	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
278137008272	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
278137008273	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
278137008274	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
278137008275	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
278137008276	putative active site [active]
278137008277	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137008278	putative transposase OrfB; Reviewed; Region: PHA02517
278137008279	HTH-like domain; Region: HTH_21; pfam13276
278137008280	Integrase core domain; Region: rve; pfam00665
278137008281	Integrase core domain; Region: rve_3; pfam13683
278137008282	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137008283	Transposase; Region: HTH_Tnp_1; cl17663
278137008284	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
278137008285	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
278137008286	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
278137008287	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
278137008288	Cysteine-rich domain; Region: CCG; pfam02754
278137008289	Cysteine-rich domain; Region: CCG; pfam02754
278137008290	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
278137008291	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
278137008292	triosephosphate isomerase; Provisional; Region: PRK14567
278137008293	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
278137008294	substrate binding site [chemical binding]; other site
278137008295	dimer interface [polypeptide binding]; other site
278137008296	catalytic triad [active]
278137008297	Phosphoglycerate kinase; Region: PGK; pfam00162
278137008298	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
278137008299	substrate binding site [chemical binding]; other site
278137008300	hinge regions; other site
278137008301	ADP binding site [chemical binding]; other site
278137008302	catalytic site [active]
278137008303	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
278137008304	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
278137008305	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
278137008306	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137008307	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137008308	substrate binding pocket [chemical binding]; other site
278137008309	membrane-bound complex binding site; other site
278137008310	hinge residues; other site
278137008311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
278137008312	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
278137008313	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
278137008314	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
278137008315	phosphate binding site [ion binding]; other site
278137008316	putative substrate binding pocket [chemical binding]; other site
278137008317	dimer interface [polypeptide binding]; other site
278137008318	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
278137008319	AAA domain; Region: AAA_18; pfam13238
278137008320	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
278137008321	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
278137008322	GIY-YIG motif/motif A; other site
278137008323	active site
278137008324	catalytic site [active]
278137008325	putative DNA binding site [nucleotide binding]; other site
278137008326	metal binding site [ion binding]; metal-binding site
278137008327	UvrB/uvrC motif; Region: UVR; pfam02151
278137008328	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
278137008329	Helix-hairpin-helix motif; Region: HHH; pfam00633
278137008330	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
278137008331	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
278137008332	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
278137008333	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
278137008334	homopentamer interface [polypeptide binding]; other site
278137008335	active site
278137008336	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
278137008337	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
278137008338	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
278137008339	dimerization interface [polypeptide binding]; other site
278137008340	active site
278137008341	PE-PPE domain; Region: PE-PPE; pfam08237
278137008342	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
278137008343	Lumazine binding domain; Region: Lum_binding; pfam00677
278137008344	Lumazine binding domain; Region: Lum_binding; pfam00677
278137008345	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
278137008346	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137008347	trehalose synthase; Region: treS_nterm; TIGR02456
278137008348	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
278137008349	active site
278137008350	catalytic site [active]
278137008351	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
278137008352	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137008353	putative substrate translocation pore; other site
278137008354	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
278137008355	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
278137008356	active site
278137008357	Zn binding site [ion binding]; other site
278137008358	RibD C-terminal domain; Region: RibD_C; pfam01872
278137008359	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
278137008360	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
278137008361	substrate binding site [chemical binding]; other site
278137008362	hexamer interface [polypeptide binding]; other site
278137008363	metal binding site [ion binding]; metal-binding site
278137008364	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
278137008365	putative RNA binding site [nucleotide binding]; other site
278137008366	16S rRNA methyltransferase B; Provisional; Region: PRK14902
278137008367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137008368	S-adenosylmethionine binding site [chemical binding]; other site
278137008369	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
278137008370	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
278137008371	putative active site [active]
278137008372	substrate binding site [chemical binding]; other site
278137008373	putative cosubstrate binding site; other site
278137008374	catalytic site [active]
278137008375	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
278137008376	substrate binding site [chemical binding]; other site
278137008377	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
278137008378	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
278137008379	primosome assembly protein PriA; Provisional; Region: PRK14873
278137008380	YhhN-like protein; Region: YhhN; pfam07947
278137008381	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137008382	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137008383	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137008384	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137008385	S-adenosylmethionine synthetase; Validated; Region: PRK05250
278137008386	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
278137008387	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
278137008388	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
278137008389	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
278137008390	Flavoprotein; Region: Flavoprotein; pfam02441
278137008391	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
278137008392	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
278137008393	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
278137008394	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
278137008395	catalytic site [active]
278137008396	G-X2-G-X-G-K; other site
278137008397	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
278137008398	active site
278137008399	dimer interface [polypeptide binding]; other site
278137008400	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
278137008401	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
278137008402	ATP-grasp domain; Region: ATP-grasp_4; cl17255
278137008403	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
278137008404	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
278137008405	ATP-grasp domain; Region: ATP-grasp_4; cl17255
278137008406	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
278137008407	IMP binding site; other site
278137008408	dimer interface [polypeptide binding]; other site
278137008409	interdomain contacts; other site
278137008410	partial ornithine binding site; other site
278137008411	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
278137008412	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
278137008413	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
278137008414	catalytic site [active]
278137008415	subunit interface [polypeptide binding]; other site
278137008416	dihydroorotase; Validated; Region: pyrC; PRK09357
278137008417	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137008418	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
278137008419	active site
278137008420	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
278137008421	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
278137008422	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
278137008423	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
278137008424	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137008425	active site
278137008426	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
278137008427	Beta-lactamase; Region: Beta-lactamase; pfam00144
278137008428	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137008429	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137008430	active site
278137008431	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
278137008432	putative RNA binding site [nucleotide binding]; other site
278137008433	elongation factor P; Validated; Region: PRK00529
278137008434	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
278137008435	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
278137008436	RNA binding site [nucleotide binding]; other site
278137008437	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
278137008438	RNA binding site [nucleotide binding]; other site
278137008439	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
278137008440	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
278137008441	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
278137008442	active site
278137008443	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
278137008444	active site
278137008445	dimer interface [polypeptide binding]; other site
278137008446	metal binding site [ion binding]; metal-binding site
278137008447	shikimate kinase; Reviewed; Region: aroK; PRK00131
278137008448	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
278137008449	ADP binding site [chemical binding]; other site
278137008450	magnesium binding site [ion binding]; other site
278137008451	putative shikimate binding site; other site
278137008452	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
278137008453	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
278137008454	Tetramer interface [polypeptide binding]; other site
278137008455	active site
278137008456	FMN-binding site [chemical binding]; other site
278137008457	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
278137008458	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
278137008459	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
278137008460	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
278137008461	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
278137008462	NAD(P) binding site [chemical binding]; other site
278137008463	shikimate binding site; other site
278137008464	YceG-like family; Region: YceG; pfam02618
278137008465	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
278137008466	dimerization interface [polypeptide binding]; other site
278137008467	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
278137008468	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
278137008469	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
278137008470	motif 1; other site
278137008471	active site
278137008472	motif 2; other site
278137008473	motif 3; other site
278137008474	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
278137008475	DHHA1 domain; Region: DHHA1; pfam02272
278137008476	Uncharacterized conserved protein [Function unknown]; Region: COG0432
278137008477	recombination factor protein RarA; Reviewed; Region: PRK13342
278137008478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137008479	Walker A motif; other site
278137008480	ATP binding site [chemical binding]; other site
278137008481	Walker B motif; other site
278137008482	arginine finger; other site
278137008483	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
278137008484	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
278137008485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
278137008486	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
278137008487	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
278137008488	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
278137008489	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
278137008490	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
278137008491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
278137008492	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
278137008493	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
278137008494	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
278137008495	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
278137008496	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
278137008497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
278137008498	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
278137008499	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
278137008500	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
278137008501	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
278137008502	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
278137008503	N- and C-terminal domain interface [polypeptide binding]; other site
278137008504	putative active site [active]
278137008505	MgATP binding site [chemical binding]; other site
278137008506	catalytic site [active]
278137008507	metal binding site [ion binding]; metal-binding site
278137008508	putative xylulose binding site [chemical binding]; other site
278137008509	putative homodimer interface [polypeptide binding]; other site
278137008510	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
278137008511	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
278137008512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137008513	dimer interface [polypeptide binding]; other site
278137008514	conserved gate region; other site
278137008515	ABC-ATPase subunit interface; other site
278137008516	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
278137008517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137008518	dimer interface [polypeptide binding]; other site
278137008519	conserved gate region; other site
278137008520	putative PBP binding loops; other site
278137008521	ABC-ATPase subunit interface; other site
278137008522	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
278137008523	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
278137008524	Walker A/P-loop; other site
278137008525	ATP binding site [chemical binding]; other site
278137008526	Q-loop/lid; other site
278137008527	ABC transporter signature motif; other site
278137008528	Walker B; other site
278137008529	D-loop; other site
278137008530	H-loop/switch region; other site
278137008531	TOBE domain; Region: TOBE; pfam03459
278137008532	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137008533	classical (c) SDRs; Region: SDR_c; cd05233
278137008534	NAD(P) binding site [chemical binding]; other site
278137008535	active site
278137008536	BtpA family; Region: BtpA; cl00440
278137008537	Predicted transcriptional regulators [Transcription]; Region: COG1733
278137008538	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
278137008539	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
278137008540	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137008541	dimer interface [polypeptide binding]; other site
278137008542	active site
278137008543	Domain of unknown function (DUF385); Region: DUF385; pfam04075
278137008544	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
278137008545	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
278137008546	dimer interface [polypeptide binding]; other site
278137008547	anticodon binding site; other site
278137008548	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
278137008549	homodimer interface [polypeptide binding]; other site
278137008550	motif 1; other site
278137008551	active site
278137008552	motif 2; other site
278137008553	GAD domain; Region: GAD; pfam02938
278137008554	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
278137008555	active site
278137008556	motif 3; other site
278137008557	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
278137008558	putative hydrophobic ligand binding site [chemical binding]; other site
278137008559	protein interface [polypeptide binding]; other site
278137008560	gate; other site
278137008561	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
278137008562	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137008563	substrate binding pocket [chemical binding]; other site
278137008564	catalytic triad [active]
278137008565	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
278137008566	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
278137008567	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
278137008568	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
278137008569	active site
278137008570	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
278137008571	catalytic triad [active]
278137008572	dimer interface [polypeptide binding]; other site
278137008573	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137008574	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137008575	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137008576	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137008577	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137008578	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137008579	active site
278137008580	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137008581	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137008582	active site
278137008583	Radical SAM superfamily; Region: Radical_SAM; pfam04055
278137008584	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
278137008585	Part of AAA domain; Region: AAA_19; pfam13245
278137008586	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
278137008587	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
278137008588	putative ligand binding site [chemical binding]; other site
278137008589	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
278137008590	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
278137008591	TM-ABC transporter signature motif; other site
278137008592	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
278137008593	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
278137008594	TM-ABC transporter signature motif; other site
278137008595	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
278137008596	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
278137008597	Walker A/P-loop; other site
278137008598	ATP binding site [chemical binding]; other site
278137008599	Q-loop/lid; other site
278137008600	ABC transporter signature motif; other site
278137008601	Walker B; other site
278137008602	D-loop; other site
278137008603	H-loop/switch region; other site
278137008604	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
278137008605	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
278137008606	Walker A/P-loop; other site
278137008607	ATP binding site [chemical binding]; other site
278137008608	Q-loop/lid; other site
278137008609	ABC transporter signature motif; other site
278137008610	Walker B; other site
278137008611	D-loop; other site
278137008612	H-loop/switch region; other site
278137008613	Predicted membrane protein [Function unknown]; Region: COG4325
278137008614	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
278137008615	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
278137008616	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137008617	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
278137008618	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137008619	DNA binding residues [nucleotide binding]
278137008620	Protein of unknown function (DUF461); Region: DUF461; pfam04314
278137008621	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
278137008622	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
278137008623	dimer interface [polypeptide binding]; other site
278137008624	motif 1; other site
278137008625	active site
278137008626	motif 2; other site
278137008627	motif 3; other site
278137008628	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
278137008629	anticodon binding site; other site
278137008630	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
278137008631	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
278137008632	active site
278137008633	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
278137008634	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
278137008635	Zn2+ binding site [ion binding]; other site
278137008636	Mg2+ binding site [ion binding]; other site
278137008637	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
278137008638	synthetase active site [active]
278137008639	NTP binding site [chemical binding]; other site
278137008640	metal binding site [ion binding]; metal-binding site
278137008641	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
278137008642	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
278137008643	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137008644	active site
278137008645	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
278137008646	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
278137008647	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
278137008648	Protein export membrane protein; Region: SecD_SecF; pfam02355
278137008649	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
278137008650	Protein export membrane protein; Region: SecD_SecF; cl14618
278137008651	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
278137008652	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
278137008653	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137008654	inhibitor-cofactor binding pocket; inhibition site
278137008655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137008656	catalytic residue [active]
278137008657	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
278137008658	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
278137008659	tetrameric interface [polypeptide binding]; other site
278137008660	NAD binding site [chemical binding]; other site
278137008661	catalytic residues [active]
278137008662	substrate binding site [chemical binding]; other site
278137008663	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137008664	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137008665	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137008666	metal binding site [ion binding]; metal-binding site
278137008667	active site
278137008668	I-site; other site
278137008669	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
278137008670	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
278137008671	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137008672	Walker A motif; other site
278137008673	ATP binding site [chemical binding]; other site
278137008674	Walker B motif; other site
278137008675	arginine finger; other site
278137008676	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
278137008677	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
278137008678	RuvA N terminal domain; Region: RuvA_N; pfam01330
278137008679	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
278137008680	active site
278137008681	putative DNA-binding cleft [nucleotide binding]; other site
278137008682	dimer interface [polypeptide binding]; other site
278137008683	hypothetical protein; Validated; Region: PRK00110
278137008684	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137008685	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137008686	active site
278137008687	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
278137008688	predicted active site [active]
278137008689	catalytic triad [active]
278137008690	acyl-CoA thioesterase II; Region: tesB; TIGR00189
278137008691	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
278137008692	active site
278137008693	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
278137008694	catalytic triad [active]
278137008695	dimer interface [polypeptide binding]; other site
278137008696	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
278137008697	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
278137008698	active site
278137008699	multimer interface [polypeptide binding]; other site
278137008700	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
278137008701	nudix motif; other site
278137008702	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137008703	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137008704	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
278137008705	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
278137008706	putative acyl-acceptor binding pocket; other site
278137008707	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
278137008708	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
278137008709	nucleotide binding site/active site [active]
278137008710	HIT family signature motif; other site
278137008711	catalytic residue [active]
278137008712	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
278137008713	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
278137008714	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
278137008715	active site
278137008716	dimer interface [polypeptide binding]; other site
278137008717	motif 1; other site
278137008718	motif 2; other site
278137008719	motif 3; other site
278137008720	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
278137008721	anticodon binding site; other site
278137008722	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
278137008723	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137008724	CoenzymeA binding site [chemical binding]; other site
278137008725	subunit interaction site [polypeptide binding]; other site
278137008726	PHB binding site; other site
278137008727	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
278137008728	GAF domain; Region: GAF; pfam01590
278137008729	GAF domain; Region: GAF_2; pfam13185
278137008730	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
278137008731	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137008732	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
278137008733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
278137008734	Histidine kinase; Region: HisKA_3; pfam07730
278137008735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137008736	ATP binding site [chemical binding]; other site
278137008737	Mg2+ binding site [ion binding]; other site
278137008738	G-X-G motif; other site
278137008739	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
278137008740	dimer interface [polypeptide binding]; other site
278137008741	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137008742	Ligand Binding Site [chemical binding]; other site
278137008743	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137008744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137008745	active site
278137008746	phosphorylation site [posttranslational modification]
278137008747	intermolecular recognition site; other site
278137008748	dimerization interface [polypeptide binding]; other site
278137008749	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137008750	DNA binding residues [nucleotide binding]
278137008751	dimerization interface [polypeptide binding]; other site
278137008752	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
278137008753	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
278137008754	active site
278137008755	catalytic site [active]
278137008756	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
278137008757	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
278137008758	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
278137008759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137008760	dimer interface [polypeptide binding]; other site
278137008761	conserved gate region; other site
278137008762	putative PBP binding loops; other site
278137008763	ABC-ATPase subunit interface; other site
278137008764	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
278137008765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137008766	dimer interface [polypeptide binding]; other site
278137008767	conserved gate region; other site
278137008768	putative PBP binding loops; other site
278137008769	ABC-ATPase subunit interface; other site
278137008770	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
278137008771	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
278137008772	Walker A/P-loop; other site
278137008773	ATP binding site [chemical binding]; other site
278137008774	Q-loop/lid; other site
278137008775	ABC transporter signature motif; other site
278137008776	Walker B; other site
278137008777	D-loop; other site
278137008778	H-loop/switch region; other site
278137008779	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
278137008780	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
278137008781	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137008782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
278137008783	PAS domain; Region: PAS_9; pfam13426
278137008784	putative active site [active]
278137008785	heme pocket [chemical binding]; other site
278137008786	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
278137008787	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
278137008788	DNA binding residues [nucleotide binding]
278137008789	TOBE domain; Region: TOBE; cl01440
278137008790	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
278137008791	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
278137008792	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
278137008793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
278137008794	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
278137008795	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137008796	Walker A/P-loop; other site
278137008797	ATP binding site [chemical binding]; other site
278137008798	Q-loop/lid; other site
278137008799	ABC transporter signature motif; other site
278137008800	Walker B; other site
278137008801	D-loop; other site
278137008802	H-loop/switch region; other site
278137008803	hypothetical protein; Provisional; Region: PRK12496
278137008804	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137008805	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
278137008806	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137008807	acyl-activating enzyme (AAE) consensus motif; other site
278137008808	AMP binding site [chemical binding]; other site
278137008809	active site
278137008810	CoA binding site [chemical binding]; other site
278137008811	PE-PPE domain; Region: PE-PPE; pfam08237
278137008812	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
278137008813	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137008814	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137008815	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
278137008816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137008817	NAD(P) binding site [chemical binding]; other site
278137008818	active site
278137008819	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
278137008820	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
278137008821	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
278137008822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137008823	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
278137008824	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137008825	DNA binding residues [nucleotide binding]
278137008826	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
278137008827	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137008828	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
278137008829	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137008830	DNA binding residues [nucleotide binding]
278137008831	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
278137008832	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
278137008833	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137008834	putative ADP-binding pocket [chemical binding]; other site
278137008835	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
278137008836	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
278137008837	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
278137008838	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
278137008839	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137008840	Response regulator receiver domain; Region: Response_reg; pfam00072
278137008841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137008842	active site
278137008843	phosphorylation site [posttranslational modification]
278137008844	intermolecular recognition site; other site
278137008845	dimerization interface [polypeptide binding]; other site
278137008846	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137008847	anti sigma factor interaction site; other site
278137008848	regulatory phosphorylation site [posttranslational modification]; other site
278137008849	CsbD-like; Region: CsbD; pfam05532
278137008850	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
278137008851	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
278137008852	putative ligand binding residues [chemical binding]; other site
278137008853	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
278137008854	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
278137008855	dimer interface [polypeptide binding]; other site
278137008856	putative PBP binding regions; other site
278137008857	ABC-ATPase subunit  interface; other site
278137008858	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
278137008859	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
278137008860	Walker A/P-loop; other site
278137008861	ATP binding site [chemical binding]; other site
278137008862	Q-loop/lid; other site
278137008863	ABC transporter signature motif; other site
278137008864	Walker B; other site
278137008865	D-loop; other site
278137008866	H-loop/switch region; other site
278137008867	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
278137008868	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137008869	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137008870	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
278137008871	metal-binding site [ion binding]
278137008872	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137008873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137008874	active site
278137008875	phosphorylation site [posttranslational modification]
278137008876	intermolecular recognition site; other site
278137008877	dimerization interface [polypeptide binding]; other site
278137008878	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137008879	DNA binding site [nucleotide binding]
278137008880	HAMP domain; Region: HAMP; pfam00672
278137008881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137008882	dimer interface [polypeptide binding]; other site
278137008883	phosphorylation site [posttranslational modification]
278137008884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137008885	Mg2+ binding site [ion binding]; other site
278137008886	G-X-G motif; other site
278137008887	Domain of unknown function (DUF305); Region: DUF305; pfam03713
278137008888	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
278137008889	Phage capsid family; Region: Phage_capsid; pfam05065
278137008890	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137008891	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137008892	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
278137008893	hydrophobic ligand binding site; other site
278137008894	Clp amino terminal domain; Region: Clp_N; pfam02861
278137008895	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
278137008896	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137008897	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
278137008898	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
278137008899	DNA binding site [nucleotide binding]
278137008900	active site
278137008901	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
278137008902	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137008903	Coenzyme A binding pocket [chemical binding]; other site
278137008904	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
278137008905	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
278137008906	hypothetical protein; Provisional; Region: PRK14059
278137008907	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
278137008908	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137008909	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137008910	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
278137008911	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
278137008912	SelR domain; Region: SelR; pfam01641
278137008913	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
278137008914	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
278137008915	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137008916	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
278137008917	substrate binding site [chemical binding]; other site
278137008918	active site
278137008919	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
278137008920	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
278137008921	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
278137008922	catalytic site [active]
278137008923	putative active site [active]
278137008924	putative substrate binding site [chemical binding]; other site
278137008925	Helicase and RNase D C-terminal; Region: HRDC; smart00341
278137008926	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137008927	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
278137008928	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
278137008929	TPP-binding site; other site
278137008930	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
278137008931	PYR/PP interface [polypeptide binding]; other site
278137008932	dimer interface [polypeptide binding]; other site
278137008933	TPP binding site [chemical binding]; other site
278137008934	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
278137008935	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
278137008936	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
278137008937	TRAM domain; Region: TRAM; pfam01938
278137008938	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
278137008939	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
278137008940	TrkA-N domain; Region: TrkA_N; pfam02254
278137008941	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
278137008942	TrkA-N domain; Region: TrkA_N; pfam02254
278137008943	TrkA-C domain; Region: TrkA_C; pfam02080
278137008944	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
278137008945	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
278137008946	generic binding surface II; other site
278137008947	ssDNA binding site; other site
278137008948	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137008949	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
278137008950	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
278137008951	trimer interface [polypeptide binding]; other site
278137008952	active site
278137008953	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
278137008954	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
278137008955	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
278137008956	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
278137008957	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
278137008958	active site
278137008959	dimerization interface [polypeptide binding]; other site
278137008960	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
278137008961	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137008962	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
278137008963	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137008964	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
278137008965	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137008966	DNA binding residues [nucleotide binding]
278137008967	O-methyltransferase; Region: Methyltransf_2; pfam00891
278137008968	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
278137008969	homotrimer interaction site [polypeptide binding]; other site
278137008970	putative active site [active]
278137008971	Protein of unknown function (DUF952); Region: DUF952; cl01393
278137008972	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
278137008973	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
278137008974	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
278137008975	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
278137008976	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
278137008977	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137008978	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
278137008979	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137008980	DNA binding residues [nucleotide binding]
278137008981	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
278137008982	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
278137008983	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
278137008984	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
278137008985	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
278137008986	PAC2 family; Region: PAC2; pfam09754
278137008987	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137008988	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137008989	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
278137008990	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
278137008991	ATP cone domain; Region: ATP-cone; pfam03477
278137008992	LysM domain; Region: LysM; pfam01476
278137008993	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
278137008994	LexA repressor; Validated; Region: PRK00215
278137008995	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
278137008996	Catalytic site [active]
278137008997	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
278137008998	LGFP repeat; Region: LGFP; pfam08310
278137008999	LGFP repeat; Region: LGFP; pfam08310
278137009000	LGFP repeat; Region: LGFP; pfam08310
278137009001	LGFP repeat; Region: LGFP; pfam08310
278137009002	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
278137009003	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
278137009004	molybdopterin cofactor binding site [chemical binding]; other site
278137009005	substrate binding site [chemical binding]; other site
278137009006	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
278137009007	molybdopterin cofactor binding site; other site
278137009008	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
278137009009	DEAD-like helicases superfamily; Region: DEXDc; smart00487
278137009010	ATP binding site [chemical binding]; other site
278137009011	Mg++ binding site [ion binding]; other site
278137009012	motif III; other site
278137009013	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137009014	nucleotide binding region [chemical binding]; other site
278137009015	ATP-binding site [chemical binding]; other site
278137009016	GTPases [General function prediction only]; Region: HflX; COG2262
278137009017	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
278137009018	HflX GTPase family; Region: HflX; cd01878
278137009019	G1 box; other site
278137009020	GTP/Mg2+ binding site [chemical binding]; other site
278137009021	Switch I region; other site
278137009022	G2 box; other site
278137009023	G3 box; other site
278137009024	Switch II region; other site
278137009025	G4 box; other site
278137009026	G5 box; other site
278137009027	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
278137009028	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
278137009029	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
278137009030	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
278137009031	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
278137009032	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
278137009033	active site
278137009034	metal binding site [ion binding]; metal-binding site
278137009035	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
278137009036	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
278137009037	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
278137009038	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
278137009039	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
278137009040	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
278137009041	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137009042	FeS/SAM binding site; other site
278137009043	TRAM domain; Region: TRAM; cl01282
278137009044	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
278137009045	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
278137009046	Walker A/P-loop; other site
278137009047	ATP binding site [chemical binding]; other site
278137009048	Q-loop/lid; other site
278137009049	ABC transporter signature motif; other site
278137009050	Walker B; other site
278137009051	D-loop; other site
278137009052	H-loop/switch region; other site
278137009053	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137009054	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137009055	substrate binding pocket [chemical binding]; other site
278137009056	membrane-bound complex binding site; other site
278137009057	hinge residues; other site
278137009058	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
278137009059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137009060	dimer interface [polypeptide binding]; other site
278137009061	conserved gate region; other site
278137009062	putative PBP binding loops; other site
278137009063	ABC-ATPase subunit interface; other site
278137009064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137009065	dimer interface [polypeptide binding]; other site
278137009066	conserved gate region; other site
278137009067	putative PBP binding loops; other site
278137009068	ABC-ATPase subunit interface; other site
278137009069	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
278137009070	recombination regulator RecX; Reviewed; Region: recX; PRK00117
278137009071	recombinase A; Provisional; Region: recA; PRK09354
278137009072	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
278137009073	hexamer interface [polypeptide binding]; other site
278137009074	Walker A motif; other site
278137009075	ATP binding site [chemical binding]; other site
278137009076	Walker B motif; other site
278137009077	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137009078	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137009079	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
278137009080	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
278137009081	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
278137009082	AAA domain; Region: AAA_22; pfam13401
278137009083	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
278137009084	Acylphosphatase; Region: Acylphosphatase; pfam00708
278137009085	HypF finger; Region: zf-HYPF; pfam07503
278137009086	HypF finger; Region: zf-HYPF; pfam07503
278137009087	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
278137009088	HupF/HypC family; Region: HupF_HypC; pfam01455
278137009089	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
278137009090	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
278137009091	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
278137009092	dimerization interface [polypeptide binding]; other site
278137009093	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
278137009094	ATP binding site [chemical binding]; other site
278137009095	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
278137009096	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
278137009097	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
278137009098	homodimer interface [polypeptide binding]; other site
278137009099	active site
278137009100	TDP-binding site; other site
278137009101	acceptor substrate-binding pocket; other site
278137009102	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137009103	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
278137009104	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137009105	non-specific DNA binding site [nucleotide binding]; other site
278137009106	salt bridge; other site
278137009107	sequence-specific DNA binding site [nucleotide binding]; other site
278137009108	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
278137009109	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137009110	Coenzyme A binding pocket [chemical binding]; other site
278137009111	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
278137009112	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
278137009113	malonyl-CoA binding site [chemical binding]; other site
278137009114	dimer interface [polypeptide binding]; other site
278137009115	active site
278137009116	product binding site; other site
278137009117	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137009118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137009119	S-adenosylmethionine binding site [chemical binding]; other site
278137009120	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
278137009121	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137009122	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
278137009123	Uncharacterized conserved protein [Function unknown]; Region: COG1359
278137009124	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
278137009125	classical (c) SDRs; Region: SDR_c; cd05233
278137009126	NAD(P) binding site [chemical binding]; other site
278137009127	active site
278137009128	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137009129	Leucine carboxyl methyltransferase; Region: LCM; cl01306
278137009130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137009131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137009132	active site
278137009133	phosphorylation site [posttranslational modification]
278137009134	intermolecular recognition site; other site
278137009135	dimerization interface [polypeptide binding]; other site
278137009136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137009137	DNA binding site [nucleotide binding]
278137009138	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
278137009139	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137009140	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
278137009141	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
278137009142	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
278137009143	dimer interface [polypeptide binding]; other site
278137009144	active site
278137009145	catalytic residue [active]
278137009146	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
278137009147	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137009148	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137009149	metal binding site [ion binding]; metal-binding site
278137009150	active site
278137009151	I-site; other site
278137009152	haloalkane dehalogenase; Provisional; Region: PRK00870
278137009153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
278137009154	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
278137009155	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
278137009156	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
278137009157	folate binding site [chemical binding]; other site
278137009158	NADP+ binding site [chemical binding]; other site
278137009159	thymidylate synthase; Reviewed; Region: thyA; PRK01827
278137009160	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
278137009161	dimerization interface [polypeptide binding]; other site
278137009162	active site
278137009163	Dienelactone hydrolase family; Region: DLH; pfam01738
278137009164	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
278137009165	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
278137009166	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
278137009167	dihydrodipicolinate reductase; Provisional; Region: PRK00048
278137009168	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137009169	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
278137009170	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137009171	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137009172	active site
278137009173	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
278137009174	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137009175	putative DNA binding site [nucleotide binding]; other site
278137009176	putative Zn2+ binding site [ion binding]; other site
278137009177	AsnC family; Region: AsnC_trans_reg; pfam01037
278137009178	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
278137009179	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
278137009180	hexamer interface [polypeptide binding]; other site
278137009181	ligand binding site [chemical binding]; other site
278137009182	putative active site [active]
278137009183	NAD(P) binding site [chemical binding]; other site
278137009184	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
278137009185	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137009186	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
278137009187	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137009188	hypothetical protein; Provisional; Region: PRK01842
278137009189	SEC-C motif; Region: SEC-C; pfam02810
278137009190	GXWXG protein; Region: GXWXG; pfam14231
278137009191	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
278137009192	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
278137009193	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
278137009194	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
278137009195	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
278137009196	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
278137009197	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
278137009198	oligomer interface [polypeptide binding]; other site
278137009199	RNA binding site [nucleotide binding]; other site
278137009200	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
278137009201	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
278137009202	RNase E interface [polypeptide binding]; other site
278137009203	trimer interface [polypeptide binding]; other site
278137009204	active site
278137009205	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
278137009206	putative nucleic acid binding region [nucleotide binding]; other site
278137009207	G-X-X-G motif; other site
278137009208	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
278137009209	RNA binding site [nucleotide binding]; other site
278137009210	domain interface; other site
278137009211	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
278137009212	16S/18S rRNA binding site [nucleotide binding]; other site
278137009213	S13e-L30e interaction site [polypeptide binding]; other site
278137009214	25S rRNA binding site [nucleotide binding]; other site
278137009215	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
278137009216	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
278137009217	active site
278137009218	Riboflavin kinase; Region: Flavokinase; pfam01687
278137009219	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
278137009220	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137009221	putative DNA binding site [nucleotide binding]; other site
278137009222	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
278137009223	FeoA domain; Region: FeoA; pfam04023
278137009224	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
278137009225	hydrophobic ligand binding site; other site
278137009226	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
278137009227	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
278137009228	RNA binding site [nucleotide binding]; other site
278137009229	active site
278137009230	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
278137009231	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
278137009232	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
278137009233	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
278137009234	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
278137009235	active site
278137009236	metal binding site [ion binding]; metal-binding site
278137009237	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
278137009238	Predicted acyl esterases [General function prediction only]; Region: COG2936
278137009239	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
278137009240	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
278137009241	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
278137009242	enoyl-CoA hydratase; Provisional; Region: PRK06190
278137009243	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137009244	substrate binding site [chemical binding]; other site
278137009245	oxyanion hole (OAH) forming residues; other site
278137009246	trimer interface [polypeptide binding]; other site
278137009247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137009248	S-adenosylmethionine binding site [chemical binding]; other site
278137009249	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
278137009250	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
278137009251	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
278137009252	DHH family; Region: DHH; pfam01368
278137009253	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
278137009254	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
278137009255	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
278137009256	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
278137009257	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
278137009258	G1 box; other site
278137009259	putative GEF interaction site [polypeptide binding]; other site
278137009260	GTP/Mg2+ binding site [chemical binding]; other site
278137009261	Switch I region; other site
278137009262	G2 box; other site
278137009263	G3 box; other site
278137009264	Switch II region; other site
278137009265	G4 box; other site
278137009266	G5 box; other site
278137009267	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
278137009268	Translation-initiation factor 2; Region: IF-2; pfam11987
278137009269	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
278137009270	Protein of unknown function (DUF448); Region: DUF448; pfam04296
278137009271	putative RNA binding cleft [nucleotide binding]; other site
278137009272	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
278137009273	NusA N-terminal domain; Region: NusA_N; pfam08529
278137009274	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
278137009275	RNA binding site [nucleotide binding]; other site
278137009276	homodimer interface [polypeptide binding]; other site
278137009277	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
278137009278	G-X-X-G motif; other site
278137009279	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
278137009280	G-X-X-G motif; other site
278137009281	ribosome maturation protein RimP; Reviewed; Region: PRK00092
278137009282	Sm and related proteins; Region: Sm_like; cl00259
278137009283	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
278137009284	putative oligomer interface [polypeptide binding]; other site
278137009285	putative RNA binding site [nucleotide binding]; other site
278137009286	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
278137009287	dinuclear metal binding motif [ion binding]; other site
278137009288	prolyl-tRNA synthetase; Provisional; Region: PRK09194
278137009289	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
278137009290	dimer interface [polypeptide binding]; other site
278137009291	motif 1; other site
278137009292	active site
278137009293	motif 2; other site
278137009294	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
278137009295	putative deacylase active site [active]
278137009296	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
278137009297	active site
278137009298	motif 3; other site
278137009299	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
278137009300	anticodon binding site; other site
278137009301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137009302	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137009303	putative substrate translocation pore; other site
278137009304	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
278137009305	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
278137009306	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
278137009307	homodimer interface [polypeptide binding]; other site
278137009308	active site
278137009309	SAM binding site [chemical binding]; other site
278137009310	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
278137009311	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
278137009312	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
278137009313	catalytic triad [active]
278137009314	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
278137009315	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
278137009316	Walker A motif; other site
278137009317	homodimer interface [polypeptide binding]; other site
278137009318	ATP binding site [chemical binding]; other site
278137009319	hydroxycobalamin binding site [chemical binding]; other site
278137009320	Walker B motif; other site
278137009321	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
278137009322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
278137009323	Walker A motif; other site
278137009324	ATP binding site [chemical binding]; other site
278137009325	Walker B motif; other site
278137009326	arginine finger; other site
278137009327	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
278137009328	metal ion-dependent adhesion site (MIDAS); other site
278137009329	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
278137009330	malate:quinone oxidoreductase; Validated; Region: PRK05257
278137009331	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
278137009332	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
278137009333	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137009334	mycothione reductase; Reviewed; Region: PRK07846
278137009335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137009336	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137009337	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
278137009338	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
278137009339	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
278137009340	Walker A/P-loop; other site
278137009341	ATP binding site [chemical binding]; other site
278137009342	Q-loop/lid; other site
278137009343	ABC transporter signature motif; other site
278137009344	Walker B; other site
278137009345	D-loop; other site
278137009346	H-loop/switch region; other site
278137009347	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
278137009348	PDGLE domain; Region: PDGLE; pfam13190
278137009349	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
278137009350	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
278137009351	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137009352	dimerization interface [polypeptide binding]; other site
278137009353	putative DNA binding site [nucleotide binding]; other site
278137009354	putative Zn2+ binding site [ion binding]; other site
278137009355	Methyltransferase domain; Region: Methyltransf_11; pfam08241
278137009356	Transcriptional regulators [Transcription]; Region: FadR; COG2186
278137009357	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137009358	DNA-binding site [nucleotide binding]; DNA binding site
278137009359	FCD domain; Region: FCD; pfam07729
278137009360	short chain dehydrogenase; Provisional; Region: PRK06057
278137009361	classical (c) SDRs; Region: SDR_c; cd05233
278137009362	NAD(P) binding site [chemical binding]; other site
278137009363	active site
278137009364	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137009365	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
278137009366	NAD(P) binding site [chemical binding]; other site
278137009367	catalytic residues [active]
278137009368	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
278137009369	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
278137009370	catalytic triad [active]
278137009371	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
278137009372	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
278137009373	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
278137009374	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
278137009375	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
278137009376	dimer interface [polypeptide binding]; other site
278137009377	active site
278137009378	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
278137009379	Ligand Binding Site [chemical binding]; other site
278137009380	Molecular Tunnel; other site
278137009381	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
278137009382	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
278137009383	ATP-grasp domain; Region: ATP-grasp_4; cl17255
278137009384	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137009385	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
278137009386	active site
278137009387	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137009388	CoenzymeA binding site [chemical binding]; other site
278137009389	subunit interaction site [polypeptide binding]; other site
278137009390	PHB binding site; other site
278137009391	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
278137009392	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
278137009393	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
278137009394	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
278137009395	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
278137009396	Predicted acetyltransferase [General function prediction only]; Region: COG3393
278137009397	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
278137009398	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
278137009399	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
278137009400	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
278137009401	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
278137009402	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
278137009403	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
278137009404	active site
278137009405	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
278137009406	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
278137009407	putative substrate binding region [chemical binding]; other site
278137009408	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
278137009409	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
278137009410	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
278137009411	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
278137009412	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
278137009413	Fasciclin domain; Region: Fasciclin; pfam02469
278137009414	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
278137009415	Fasciclin domain; Region: Fasciclin; pfam02469
278137009416	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
278137009417	DNA photolyase; Region: DNA_photolyase; pfam00875
278137009418	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137009419	classical (c) SDRs; Region: SDR_c; cd05233
278137009420	NAD(P) binding site [chemical binding]; other site
278137009421	active site
278137009422	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
278137009423	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137009424	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137009425	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
278137009426	Domain of unknown function (DUF427); Region: DUF427; pfam04248
278137009427	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
278137009428	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
278137009429	active site
278137009430	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
278137009431	catalytic triad [active]
278137009432	dimer interface [polypeptide binding]; other site
278137009433	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
278137009434	Prostaglandin dehydrogenases; Region: PGDH; cd05288
278137009435	NAD(P) binding site [chemical binding]; other site
278137009436	substrate binding site [chemical binding]; other site
278137009437	dimer interface [polypeptide binding]; other site
278137009438	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
278137009439	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
278137009440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137009441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137009442	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137009443	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137009444	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137009445	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
278137009446	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137009447	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137009448	active site
278137009449	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137009450	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137009451	active site
278137009452	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
278137009453	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137009454	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137009455	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137009456	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
278137009457	classical (c) SDRs; Region: SDR_c; cd05233
278137009458	NAD(P) binding site [chemical binding]; other site
278137009459	active site
278137009460	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
278137009461	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137009462	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
278137009463	NAD(P) binding site [chemical binding]; other site
278137009464	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137009465	Cytochrome P450; Region: p450; cl12078
278137009466	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
278137009467	Strictosidine synthase; Region: Str_synth; pfam03088
278137009468	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
278137009469	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
278137009470	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
278137009471	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137009472	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137009473	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137009474	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137009475	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
278137009476	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137009477	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137009478	Ecdysteroid kinase; Region: EcKinase; cl17738
278137009479	Phosphotransferase enzyme family; Region: APH; pfam01636
278137009480	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137009481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137009482	sequence-specific DNA binding site [nucleotide binding]; other site
278137009483	salt bridge; other site
278137009484	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
278137009485	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
278137009486	NAD binding site [chemical binding]; other site
278137009487	catalytic residues [active]
278137009488	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137009489	SnoaL-like domain; Region: SnoaL_3; pfam13474
278137009490	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
278137009491	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137009492	FeS/SAM binding site; other site
278137009493	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
278137009494	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
278137009495	ribosome recycling factor; Reviewed; Region: frr; PRK00083
278137009496	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
278137009497	hinge region; other site
278137009498	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
278137009499	putative nucleotide binding site [chemical binding]; other site
278137009500	uridine monophosphate binding site [chemical binding]; other site
278137009501	homohexameric interface [polypeptide binding]; other site
278137009502	tyramine oxidase; Provisional; Region: tynA; PRK11504
278137009503	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
278137009504	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
278137009505	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
278137009506	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
278137009507	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
278137009508	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
278137009509	Walker A/P-loop; other site
278137009510	ATP binding site [chemical binding]; other site
278137009511	Q-loop/lid; other site
278137009512	ABC transporter signature motif; other site
278137009513	Walker B; other site
278137009514	D-loop; other site
278137009515	H-loop/switch region; other site
278137009516	FtsX-like permease family; Region: FtsX; pfam02687
278137009517	amidase; Provisional; Region: PRK07869
278137009518	Amidase; Region: Amidase; cl11426
278137009519	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
278137009520	Bacterial sugar transferase; Region: Bac_transf; pfam02397
278137009521	elongation factor Ts; Provisional; Region: tsf; PRK09377
278137009522	UBA/TS-N domain; Region: UBA; pfam00627
278137009523	Elongation factor TS; Region: EF_TS; pfam00889
278137009524	Elongation factor TS; Region: EF_TS; pfam00889
278137009525	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
278137009526	rRNA interaction site [nucleotide binding]; other site
278137009527	S8 interaction site; other site
278137009528	putative laminin-1 binding site; other site
278137009529	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
278137009530	Peptidase family M23; Region: Peptidase_M23; pfam01551
278137009531	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
278137009532	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137009533	active site
278137009534	DNA binding site [nucleotide binding]
278137009535	Int/Topo IB signature motif; other site
278137009536	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
278137009537	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
278137009538	putative active site [active]
278137009539	putative substrate binding site [chemical binding]; other site
278137009540	putative FMN binding site [chemical binding]; other site
278137009541	putative catalytic residues [active]
278137009542	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
278137009543	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
278137009544	FAD binding pocket [chemical binding]; other site
278137009545	FAD binding motif [chemical binding]; other site
278137009546	phosphate binding motif [ion binding]; other site
278137009547	NAD binding pocket [chemical binding]; other site
278137009548	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
278137009549	DNA protecting protein DprA; Region: dprA; TIGR00732
278137009550	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
278137009551	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
278137009552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137009553	Walker A motif; other site
278137009554	ATP binding site [chemical binding]; other site
278137009555	Walker B motif; other site
278137009556	arginine finger; other site
278137009557	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
278137009558	hypothetical protein; Reviewed; Region: PRK12497
278137009559	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
278137009560	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
278137009561	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
278137009562	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
278137009563	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137009564	active site
278137009565	CoA binding site [chemical binding]; other site
278137009566	AMP binding site [chemical binding]; other site
278137009567	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137009568	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
278137009569	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
278137009570	active site
278137009571	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
278137009572	catalytic triad [active]
278137009573	dimer interface [polypeptide binding]; other site
278137009574	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
278137009575	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137009576	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137009577	Cytochrome P450; Region: p450; cl12078
278137009578	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137009579	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137009580	classical (c) SDRs; Region: SDR_c; cd05233
278137009581	NAD(P) binding site [chemical binding]; other site
278137009582	active site
278137009583	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137009584	Cytochrome P450; Region: p450; cl12078
278137009585	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137009586	Cytochrome P450; Region: p450; cl12078
278137009587	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
278137009588	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
278137009589	NAD binding site [chemical binding]; other site
278137009590	catalytic residues [active]
278137009591	short chain dehydrogenase; Provisional; Region: PRK06179
278137009592	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137009593	NAD(P) binding site [chemical binding]; other site
278137009594	active site
278137009595	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
278137009596	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
278137009597	ligand binding site [chemical binding]; other site
278137009598	MoxR-like ATPases [General function prediction only]; Region: COG0714
278137009599	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
278137009600	Walker A motif; other site
278137009601	ATP binding site [chemical binding]; other site
278137009602	Walker B motif; other site
278137009603	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
278137009604	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
278137009605	metal ion-dependent adhesion site (MIDAS); other site
278137009606	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137009607	short chain dehydrogenase; Provisional; Region: PRK07791
278137009608	NAD(P) binding site [chemical binding]; other site
278137009609	active site
278137009610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137009611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137009612	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137009613	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137009614	mce related protein; Region: MCE; pfam02470
278137009615	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137009616	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137009617	mce related protein; Region: MCE; pfam02470
278137009618	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
278137009619	mce related protein; Region: MCE; pfam02470
278137009620	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137009621	mce related protein; Region: MCE; pfam02470
278137009622	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137009623	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137009624	mce related protein; Region: MCE; pfam02470
278137009625	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137009626	mce related protein; Region: MCE; pfam02470
278137009627	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
278137009628	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
278137009629	RNA/DNA hybrid binding site [nucleotide binding]; other site
278137009630	active site
278137009631	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
278137009632	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
278137009633	Catalytic site [active]
278137009634	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
278137009635	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
278137009636	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
278137009637	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
278137009638	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
278137009639	RimM N-terminal domain; Region: RimM; pfam01782
278137009640	PRC-barrel domain; Region: PRC; pfam05239
278137009641	hypothetical protein; Provisional; Region: PRK02821
278137009642	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
278137009643	G-X-X-G motif; other site
278137009644	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
278137009645	MgtE intracellular N domain; Region: MgtE_N; smart00924
278137009646	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
278137009647	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
278137009648	Divalent cation transporter; Region: MgtE; cl00786
278137009649	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137009650	SnoaL-like domain; Region: SnoaL_3; pfam13474
278137009651	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
278137009652	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
278137009653	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
278137009654	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
278137009655	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
278137009656	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
278137009657	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137009658	active site
278137009659	signal recognition particle protein; Provisional; Region: PRK10867
278137009660	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
278137009661	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
278137009662	P loop; other site
278137009663	GTP binding site [chemical binding]; other site
278137009664	Signal peptide binding domain; Region: SRP_SPB; pfam02978
278137009665	PII uridylyl-transferase; Provisional; Region: PRK03381
278137009666	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
278137009667	metal binding triad; other site
278137009668	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
278137009669	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
278137009670	Zn2+ binding site [ion binding]; other site
278137009671	Mg2+ binding site [ion binding]; other site
278137009672	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
278137009673	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
278137009674	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
278137009675	Nitrogen regulatory protein P-II; Region: P-II; smart00938
278137009676	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
278137009677	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
278137009678	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
278137009679	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
278137009680	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
278137009681	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
278137009682	homotetramer interface [polypeptide binding]; other site
278137009683	FMN binding site [chemical binding]; other site
278137009684	homodimer contacts [polypeptide binding]; other site
278137009685	putative active site [active]
278137009686	putative substrate binding site [chemical binding]; other site
278137009687	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
278137009688	AAA domain; Region: AAA_23; pfam13476
278137009689	Walker A/P-loop; other site
278137009690	ATP binding site [chemical binding]; other site
278137009691	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
278137009692	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
278137009693	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
278137009694	ABC transporter signature motif; other site
278137009695	Walker B; other site
278137009696	D-loop; other site
278137009697	H-loop/switch region; other site
278137009698	acylphosphatase; Provisional; Region: PRK14422
278137009699	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
278137009700	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
278137009701	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
278137009702	DNA binding site [nucleotide binding]
278137009703	catalytic residue [active]
278137009704	H2TH interface [polypeptide binding]; other site
278137009705	putative catalytic residues [active]
278137009706	turnover-facilitating residue; other site
278137009707	intercalation triad [nucleotide binding]; other site
278137009708	8OG recognition residue [nucleotide binding]; other site
278137009709	putative reading head residues; other site
278137009710	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
278137009711	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
278137009712	ribonuclease III; Reviewed; Region: rnc; PRK00102
278137009713	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
278137009714	dimerization interface [polypeptide binding]; other site
278137009715	active site
278137009716	metal binding site [ion binding]; metal-binding site
278137009717	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
278137009718	dsRNA binding site [nucleotide binding]; other site
278137009719	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
278137009720	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
278137009721	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
278137009722	Hemerythrin-like domain; Region: Hr-like; cd12108
278137009723	Fe binding site [ion binding]; other site
278137009724	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
278137009725	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
278137009726	active site
278137009727	(T/H)XGH motif; other site
278137009728	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
278137009729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137009730	S-adenosylmethionine binding site [chemical binding]; other site
278137009731	pyruvate carboxylase; Reviewed; Region: PRK12999
278137009732	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
278137009733	ATP-grasp domain; Region: ATP-grasp_4; cl17255
278137009734	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
278137009735	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
278137009736	active site
278137009737	catalytic residues [active]
278137009738	metal binding site [ion binding]; metal-binding site
278137009739	homodimer binding site [polypeptide binding]; other site
278137009740	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
278137009741	carboxyltransferase (CT) interaction site; other site
278137009742	biotinylation site [posttranslational modification]; other site
278137009743	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137009744	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137009745	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137009746	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
278137009747	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137009748	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
278137009749	putative active site [active]
278137009750	redox center [active]
278137009751	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
278137009752	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
278137009753	catalytic residues [active]
278137009754	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137009755	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137009756	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137009757	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
278137009758	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
278137009759	active site
278137009760	catalytic tetrad [active]
278137009761	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
278137009762	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
278137009763	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
278137009764	Protein of unknown function (DUF461); Region: DUF461; pfam04314
278137009765	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
278137009766	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
278137009767	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
278137009768	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
278137009769	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
278137009770	generic binding surface II; other site
278137009771	ssDNA binding site; other site
278137009772	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137009773	ATP binding site [chemical binding]; other site
278137009774	putative Mg++ binding site [ion binding]; other site
278137009775	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137009776	nucleotide binding region [chemical binding]; other site
278137009777	ATP-binding site [chemical binding]; other site
278137009778	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
278137009779	DAK2 domain; Region: Dak2; cl03685
278137009780	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
278137009781	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
278137009782	ligand binding site [chemical binding]; other site
278137009783	active site
278137009784	UGI interface [polypeptide binding]; other site
278137009785	catalytic site [active]
278137009786	thiamine monophosphate kinase; Provisional; Region: PRK05731
278137009787	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
278137009788	ATP binding site [chemical binding]; other site
278137009789	dimerization interface [polypeptide binding]; other site
278137009790	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
278137009791	AsnC family; Region: AsnC_trans_reg; pfam01037
278137009792	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
278137009793	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
278137009794	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
278137009795	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
278137009796	cystathionine gamma-lyase; Validated; Region: PRK07582
278137009797	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
278137009798	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137009799	catalytic residue [active]
278137009800	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
278137009801	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
278137009802	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
278137009803	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
278137009804	polyphosphate kinase; Provisional; Region: PRK05443
278137009805	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
278137009806	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
278137009807	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
278137009808	putative domain interface [polypeptide binding]; other site
278137009809	putative active site [active]
278137009810	catalytic site [active]
278137009811	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
278137009812	putative active site [active]
278137009813	catalytic site [active]
278137009814	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
278137009815	active site
278137009816	Ap6A binding site [chemical binding]; other site
278137009817	nudix motif; other site
278137009818	metal binding site [ion binding]; metal-binding site
278137009819	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137009820	catalytic core [active]
278137009821	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
278137009822	IHF - DNA interface [nucleotide binding]; other site
278137009823	IHF dimer interface [polypeptide binding]; other site
278137009824	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
278137009825	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
278137009826	substrate binding site [chemical binding]; other site
278137009827	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
278137009828	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
278137009829	substrate binding site [chemical binding]; other site
278137009830	ligand binding site [chemical binding]; other site
278137009831	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
278137009832	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137009833	Bacterial transcriptional regulator; Region: IclR; pfam01614
278137009834	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
278137009835	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
278137009836	HIGH motif; other site
278137009837	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
278137009838	active site
278137009839	KMSKS motif; other site
278137009840	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
278137009841	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
278137009842	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
278137009843	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
278137009844	tartrate dehydrogenase; Region: TTC; TIGR02089
278137009845	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
278137009846	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
278137009847	ligand binding site [chemical binding]; other site
278137009848	NAD binding site [chemical binding]; other site
278137009849	dimerization interface [polypeptide binding]; other site
278137009850	catalytic site [active]
278137009851	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
278137009852	putative L-serine binding site [chemical binding]; other site
278137009853	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
278137009854	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137009855	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
278137009856	ketol-acid reductoisomerase; Provisional; Region: PRK05479
278137009857	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
278137009858	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
278137009859	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
278137009860	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
278137009861	putative valine binding site [chemical binding]; other site
278137009862	dimer interface [polypeptide binding]; other site
278137009863	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
278137009864	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
278137009865	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
278137009866	PYR/PP interface [polypeptide binding]; other site
278137009867	dimer interface [polypeptide binding]; other site
278137009868	TPP binding site [chemical binding]; other site
278137009869	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
278137009870	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
278137009871	TPP-binding site [chemical binding]; other site
278137009872	dimer interface [polypeptide binding]; other site
278137009873	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
278137009874	Predicted membrane protein [Function unknown]; Region: COG2259
278137009875	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
278137009876	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137009877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137009878	dimer interface [polypeptide binding]; other site
278137009879	phosphorylation site [posttranslational modification]
278137009880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137009881	ATP binding site [chemical binding]; other site
278137009882	Mg2+ binding site [ion binding]; other site
278137009883	G-X-G motif; other site
278137009884	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
278137009885	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
278137009886	GatB domain; Region: GatB_Yqey; smart00845
278137009887	6-phosphofructokinase; Provisional; Region: PRK03202
278137009888	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
278137009889	active site
278137009890	ADP/pyrophosphate binding site [chemical binding]; other site
278137009891	dimerization interface [polypeptide binding]; other site
278137009892	allosteric effector site; other site
278137009893	fructose-1,6-bisphosphate binding site; other site
278137009894	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
278137009895	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
278137009896	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
278137009897	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
278137009898	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
278137009899	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
278137009900	nucleotide binding pocket [chemical binding]; other site
278137009901	K-X-D-G motif; other site
278137009902	catalytic site [active]
278137009903	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
278137009904	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
278137009905	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
278137009906	Dimer interface [polypeptide binding]; other site
278137009907	Protein of unknown function (DUF419); Region: DUF419; pfam04237
278137009908	4-coumarate--CoA ligase; Region: PLN02246
278137009909	4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
278137009910	acyl-activating enzyme (AAE) consensus motif; other site
278137009911	active site
278137009912	putative CoA binding site [chemical binding]; other site
278137009913	AMP binding site [chemical binding]; other site
278137009914	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137009915	GAF domain; Region: GAF; pfam01590
278137009916	PAS fold; Region: PAS_4; pfam08448
278137009917	PAS fold; Region: PAS; pfam00989
278137009918	PAS domain; Region: PAS; smart00091
278137009919	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137009920	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137009921	metal binding site [ion binding]; metal-binding site
278137009922	active site
278137009923	I-site; other site
278137009924	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
278137009925	PknH-like extracellular domain; Region: PknH_C; pfam14032
278137009926	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
278137009927	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
278137009928	Ligand Binding Site [chemical binding]; other site
278137009929	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
278137009930	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
278137009931	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137009932	catalytic residue [active]
278137009933	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137009934	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
278137009935	putative acyl-acceptor binding pocket; other site
278137009936	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
278137009937	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
278137009938	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
278137009939	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
278137009940	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
278137009941	Ligand binding site [chemical binding]; other site
278137009942	Electron transfer flavoprotein domain; Region: ETF; pfam01012
278137009943	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137009944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137009945	S-adenosylmethionine binding site [chemical binding]; other site
278137009946	Uncharacterized conserved protein [Function unknown]; Region: COG1543
278137009947	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
278137009948	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
278137009949	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137009950	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137009951	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
278137009952	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
278137009953	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
278137009954	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
278137009955	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
278137009956	trimer interface [polypeptide binding]; other site
278137009957	active site
278137009958	substrate binding site [chemical binding]; other site
278137009959	CoA binding site [chemical binding]; other site
278137009960	FOG: WD40-like repeat [Function unknown]; Region: COG1520
278137009961	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
278137009962	active site
278137009963	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
278137009964	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
278137009965	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
278137009966	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137009967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137009968	S-adenosylmethionine binding site [chemical binding]; other site
278137009969	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137009970	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137009971	substrate binding site [chemical binding]; other site
278137009972	oxyanion hole (OAH) forming residues; other site
278137009973	trimer interface [polypeptide binding]; other site
278137009974	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
278137009975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137009976	Walker A/P-loop; other site
278137009977	ATP binding site [chemical binding]; other site
278137009978	Q-loop/lid; other site
278137009979	ABC transporter signature motif; other site
278137009980	Walker B; other site
278137009981	D-loop; other site
278137009982	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
278137009983	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
278137009984	active site
278137009985	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
278137009986	Predicted membrane protein [Function unknown]; Region: COG2364
278137009987	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
278137009988	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137009989	DNA-binding site [nucleotide binding]; DNA binding site
278137009990	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137009991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137009992	homodimer interface [polypeptide binding]; other site
278137009993	catalytic residue [active]
278137009994	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
278137009995	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
278137009996	phosphoserine phosphatase SerB; Region: serB; TIGR00338
278137009997	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
278137009998	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137009999	motif II; other site
278137010000	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
278137010001	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
278137010002	D-pathway; other site
278137010003	Putative ubiquinol binding site [chemical binding]; other site
278137010004	Low-spin heme (heme b) binding site [chemical binding]; other site
278137010005	Putative water exit pathway; other site
278137010006	Binuclear center (heme o3/CuB) [ion binding]; other site
278137010007	K-pathway; other site
278137010008	Putative proton exit pathway; other site
278137010009	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
278137010010	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
278137010011	siderophore binding site; other site
278137010012	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
278137010013	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
278137010014	putative NAD(P) binding site [chemical binding]; other site
278137010015	putative substrate binding site [chemical binding]; other site
278137010016	catalytic Zn binding site [ion binding]; other site
278137010017	structural Zn binding site [ion binding]; other site
278137010018	dimer interface [polypeptide binding]; other site
278137010019	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
278137010020	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010021	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010022	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137010023	Cytochrome P450; Region: p450; cl12078
278137010024	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
278137010025	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
278137010026	dimer interface [polypeptide binding]; other site
278137010027	putative radical transfer pathway; other site
278137010028	diiron center [ion binding]; other site
278137010029	tyrosyl radical; other site
278137010030	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137010031	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137010032	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
278137010033	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
278137010034	Zn2+ binding site [ion binding]; other site
278137010035	Mg2+ binding site [ion binding]; other site
278137010036	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137010037	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137010038	DNA binding residues [nucleotide binding]
278137010039	dimerization interface [polypeptide binding]; other site
278137010040	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010041	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010042	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
278137010043	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
278137010044	active site
278137010045	nucleophile elbow; other site
278137010046	TIR domain; Region: TIR_2; pfam13676
278137010047	AAA ATPase domain; Region: AAA_16; pfam13191
278137010048	FOG: WD40 repeat [General function prediction only]; Region: COG2319
278137010049	WD domain, G-beta repeat; Region: WD40; pfam00400
278137010050	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
278137010051	structural tetrad; other site
278137010052	FOG: WD40 repeat [General function prediction only]; Region: COG2319
278137010053	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
278137010054	structural tetrad; other site
278137010055	WD domain, G-beta repeat; Region: WD40; pfam00400
278137010056	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137010057	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
278137010058	Cupin domain; Region: Cupin_2; cl17218
278137010059	Predicted transcriptional regulator [Transcription]; Region: COG2345
278137010060	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
278137010061	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137010062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137010063	S-adenosylmethionine binding site [chemical binding]; other site
278137010064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
278137010065	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
278137010066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137010067	Walker A/P-loop; other site
278137010068	ATP binding site [chemical binding]; other site
278137010069	Q-loop/lid; other site
278137010070	ABC transporter signature motif; other site
278137010071	Walker B; other site
278137010072	D-loop; other site
278137010073	H-loop/switch region; other site
278137010074	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
278137010075	dimerization interface [polypeptide binding]; other site
278137010076	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
278137010077	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
278137010078	Class I ribonucleotide reductase; Region: RNR_I; cd01679
278137010079	active site
278137010080	dimer interface [polypeptide binding]; other site
278137010081	catalytic residues [active]
278137010082	effector binding site; other site
278137010083	R2 peptide binding site; other site
278137010084	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
278137010085	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
278137010086	catalytic residues [active]
278137010087	Predicted flavoprotein [General function prediction only]; Region: COG0431
278137010088	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
278137010089	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010090	DNA polymerase IV; Validated; Region: PRK03352
278137010091	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
278137010092	active site
278137010093	DNA binding site [nucleotide binding]
278137010094	GAF domain; Region: GAF; pfam01590
278137010095	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137010096	Predicted ATPase [General function prediction only]; Region: COG4637
278137010097	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137010098	Walker A/P-loop; other site
278137010099	ATP binding site [chemical binding]; other site
278137010100	short chain dehydrogenase; Provisional; Region: PRK07832
278137010101	classical (c) SDRs; Region: SDR_c; cd05233
278137010102	NAD(P) binding site [chemical binding]; other site
278137010103	active site
278137010104	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010105	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010106	Cytochrome P450; Region: p450; cl12078
278137010107	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137010108	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
278137010109	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
278137010110	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
278137010111	Phosphotransferase enzyme family; Region: APH; pfam01636
278137010112	putative active site [active]
278137010113	putative substrate binding site [chemical binding]; other site
278137010114	ATP binding site [chemical binding]; other site
278137010115	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
278137010116	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137010117	NAD(P) binding site [chemical binding]; other site
278137010118	active site
278137010119	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
278137010120	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
278137010121	Moco binding site; other site
278137010122	metal coordination site [ion binding]; other site
278137010123	dimerization interface [polypeptide binding]; other site
278137010124	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
278137010125	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
278137010126	active site
278137010127	DNA binding site [nucleotide binding]
278137010128	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
278137010129	DNA binding site [nucleotide binding]
278137010130	carbon starvation protein A; Provisional; Region: PRK15015
278137010131	Carbon starvation protein CstA; Region: CstA; pfam02554
278137010132	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
278137010133	Protein of unknown function (DUF466); Region: DUF466; cl01082
278137010134	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137010135	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137010136	Cytochrome P450; Region: p450; cl12078
278137010137	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
278137010138	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137010139	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
278137010140	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
278137010141	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
278137010142	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
278137010143	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137010144	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137010145	Phosphotransferase enzyme family; Region: APH; pfam01636
278137010146	Ecdysteroid kinase; Region: EcKinase; cl17738
278137010147	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
278137010148	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137010149	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137010150	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137010151	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137010152	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
278137010153	[2Fe-2S] cluster binding site [ion binding]; other site
278137010154	Isochorismatase family; Region: Isochorismatase; pfam00857
278137010155	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
278137010156	catalytic triad [active]
278137010157	conserved cis-peptide bond; other site
278137010158	acyl-CoA synthetase; Validated; Region: PRK07798
278137010159	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137010160	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
278137010161	acyl-activating enzyme (AAE) consensus motif; other site
278137010162	acyl-activating enzyme (AAE) consensus motif; other site
278137010163	putative AMP binding site [chemical binding]; other site
278137010164	putative active site [active]
278137010165	putative CoA binding site [chemical binding]; other site
278137010166	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
278137010167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137010168	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
278137010169	NAD(P) binding site [chemical binding]; other site
278137010170	active site
278137010171	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137010172	Cytochrome P450; Region: p450; cl12078
278137010173	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
278137010174	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
278137010175	NAD binding site [chemical binding]; other site
278137010176	catalytic residues [active]
278137010177	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137010178	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137010179	Integrase core domain; Region: rve; pfam00665
278137010180	Integrase core domain; Region: rve_3; pfam13683
278137010181	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137010182	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
278137010183	molybdopterin cofactor binding site; other site
278137010184	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
278137010185	molybdopterin cofactor binding site; other site
278137010186	YacP-like NYN domain; Region: NYN_YacP; cl01491
278137010187	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137010188	Cytochrome P450; Region: p450; cl12078
278137010189	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
278137010190	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
278137010191	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137010192	active site
278137010193	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010194	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010195	active site
278137010196	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
278137010197	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137010198	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010199	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
278137010200	acyl-CoA synthetase; Validated; Region: PRK07798
278137010201	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137010202	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
278137010203	acyl-activating enzyme (AAE) consensus motif; other site
278137010204	acyl-activating enzyme (AAE) consensus motif; other site
278137010205	putative AMP binding site [chemical binding]; other site
278137010206	putative active site [active]
278137010207	putative CoA binding site [chemical binding]; other site
278137010208	Amidohydrolase; Region: Amidohydro_2; pfam04909
278137010209	enoyl-CoA hydratase; Provisional; Region: PRK06210
278137010210	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137010211	substrate binding site [chemical binding]; other site
278137010212	oxyanion hole (OAH) forming residues; other site
278137010213	trimer interface [polypeptide binding]; other site
278137010214	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
278137010215	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
278137010216	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
278137010217	active site
278137010218	inhibitor site; inhibition site
278137010219	dimer interface [polypeptide binding]; other site
278137010220	catalytic residue [active]
278137010221	enoyl-CoA hydratase; Provisional; Region: PRK08252
278137010222	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137010223	substrate binding site [chemical binding]; other site
278137010224	oxyanion hole (OAH) forming residues; other site
278137010225	trimer interface [polypeptide binding]; other site
278137010226	tetracycline repressor protein TetR; Provisional; Region: PRK13756
278137010227	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010228	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
278137010229	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137010230	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
278137010231	dimer interface [polypeptide binding]; other site
278137010232	active site
278137010233	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
278137010234	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137010235	substrate binding site [chemical binding]; other site
278137010236	oxyanion hole (OAH) forming residues; other site
278137010237	trimer interface [polypeptide binding]; other site
278137010238	Transcriptional regulators [Transcription]; Region: FadR; COG2186
278137010239	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137010240	DNA-binding site [nucleotide binding]; DNA binding site
278137010241	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
278137010242	enoyl-CoA hydratase; Provisional; Region: PRK06688
278137010243	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137010244	substrate binding site [chemical binding]; other site
278137010245	oxyanion hole (OAH) forming residues; other site
278137010246	trimer interface [polypeptide binding]; other site
278137010247	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137010248	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137010249	substrate binding site [chemical binding]; other site
278137010250	oxyanion hole (OAH) forming residues; other site
278137010251	trimer interface [polypeptide binding]; other site
278137010252	enoyl-CoA hydratase; Provisional; Region: PRK08290
278137010253	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137010254	substrate binding site [chemical binding]; other site
278137010255	oxyanion hole (OAH) forming residues; other site
278137010256	trimer interface [polypeptide binding]; other site
278137010257	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
278137010258	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137010259	AMP binding site [chemical binding]; other site
278137010260	active site
278137010261	acyl-activating enzyme (AAE) consensus motif; other site
278137010262	CoA binding site [chemical binding]; other site
278137010263	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
278137010264	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137010265	acyl-activating enzyme (AAE) consensus motif; other site
278137010266	AMP binding site [chemical binding]; other site
278137010267	active site
278137010268	CoA binding site [chemical binding]; other site
278137010269	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137010270	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
278137010271	acyl-activating enzyme (AAE) consensus motif; other site
278137010272	AMP binding site [chemical binding]; other site
278137010273	active site
278137010274	CoA binding site [chemical binding]; other site
278137010275	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137010276	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137010277	Transcriptional regulators [Transcription]; Region: FadR; COG2186
278137010278	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137010279	DNA-binding site [nucleotide binding]; DNA binding site
278137010280	FCD domain; Region: FCD; pfam07729
278137010281	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010282	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010283	active site
278137010284	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
278137010285	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137010286	dimer interface [polypeptide binding]; other site
278137010287	active site
278137010288	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137010289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137010290	NAD(P) binding site [chemical binding]; other site
278137010291	active site
278137010292	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010293	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010294	active site
278137010295	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137010296	classical (c) SDRs; Region: SDR_c; cd05233
278137010297	NAD(P) binding site [chemical binding]; other site
278137010298	active site
278137010299	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137010300	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137010301	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
278137010302	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
278137010303	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137010304	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
278137010305	putative active site [active]
278137010306	putative catalytic site [active]
278137010307	hypothetical protein; Provisional; Region: PRK07877
278137010308	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
278137010309	ATP binding site [chemical binding]; other site
278137010310	substrate interface [chemical binding]; other site
278137010311	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137010312	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
278137010313	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137010314	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137010315	metal binding site [ion binding]; metal-binding site
278137010316	active site
278137010317	I-site; other site
278137010318	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137010319	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
278137010320	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
278137010321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010322	active site
278137010323	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
278137010324	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137010325	active site
278137010326	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137010327	Ligand Binding Site [chemical binding]; other site
278137010328	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137010329	Ligand Binding Site [chemical binding]; other site
278137010330	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010331	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
278137010332	putative catalytic site [active]
278137010333	putative metal binding site [ion binding]; other site
278137010334	putative phosphate binding site [ion binding]; other site
278137010335	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
278137010336	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
278137010337	ligand binding site [chemical binding]; other site
278137010338	flexible hinge region; other site
278137010339	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
278137010340	putative switch regulator; other site
278137010341	non-specific DNA interactions [nucleotide binding]; other site
278137010342	DNA binding site [nucleotide binding]
278137010343	sequence specific DNA binding site [nucleotide binding]; other site
278137010344	putative cAMP binding site [chemical binding]; other site
278137010345	Transposase domain (DUF772); Region: DUF772; pfam05598
278137010346	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137010347	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
278137010348	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
278137010349	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
278137010350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010351	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
278137010352	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137010353	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
278137010354	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
278137010355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137010356	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137010357	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137010358	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137010359	active site
278137010360	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
278137010361	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137010362	substrate binding pocket [chemical binding]; other site
278137010363	catalytic triad [active]
278137010364	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
278137010365	active site
278137010366	Uncharacterized conserved protein [Function unknown]; Region: COG5361
278137010367	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
278137010368	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137010369	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137010370	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
278137010371	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137010372	Transposase; Region: HTH_Tnp_1; pfam01527
278137010373	HTH-like domain; Region: HTH_21; pfam13276
278137010374	Integrase core domain; Region: rve; pfam00665
278137010375	Integrase core domain; Region: rve_3; pfam13683
278137010376	putative transposase OrfB; Reviewed; Region: PHA02517
278137010377	Integrase core domain; Region: rve; pfam00665
278137010378	Integrase core domain; Region: rve_3; cl15866
278137010379	HTH-like domain; Region: HTH_21; pfam13276
278137010380	Integrase core domain; Region: rve; pfam00665
278137010381	Integrase core domain; Region: rve_3; pfam13683
278137010382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137010383	Transposase; Region: HTH_Tnp_1; pfam01527
278137010384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137010385	Transposase; Region: HTH_Tnp_1; pfam01527
278137010386	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137010387	MULE transposase domain; Region: MULE; pfam10551
278137010388	Protein of unknown function DUF45; Region: DUF45; pfam01863
278137010389	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
278137010390	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
278137010391	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137010392	ATP binding site [chemical binding]; other site
278137010393	putative Mg++ binding site [ion binding]; other site
278137010394	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
278137010395	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
278137010396	HsdM N-terminal domain; Region: HsdM_N; pfam12161
278137010397	Methyltransferase domain; Region: Methyltransf_26; pfam13659
278137010398	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137010399	MULE transposase domain; Region: MULE; pfam10551
278137010400	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
278137010401	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
278137010402	GIY-YIG motif/motif A; other site
278137010403	putative active site [active]
278137010404	putative metal binding site [ion binding]; other site
278137010405	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
278137010406	AAA-like domain; Region: AAA_10; pfam12846
278137010407	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
278137010408	Walker B motif; other site
278137010409	Replication-relaxation; Region: Replic_Relax; pfam13814
278137010410	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
278137010411	DNA methylase; Region: N6_N4_Mtase; pfam01555
278137010412	Antirestriction protein (ArdA); Region: ArdA; cl01953
278137010413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137010414	Transposase; Region: HTH_Tnp_1; pfam01527
278137010415	HTH-like domain; Region: HTH_21; pfam13276
278137010416	Integrase core domain; Region: rve; pfam00665
278137010417	Integrase core domain; Region: rve_3; pfam13683
278137010418	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137010419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137010420	non-specific DNA binding site [nucleotide binding]; other site
278137010421	salt bridge; other site
278137010422	sequence-specific DNA binding site [nucleotide binding]; other site
278137010423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137010424	putative substrate translocation pore; other site
278137010425	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137010426	phosphoglucomutase; Validated; Region: PRK07564
278137010427	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
278137010428	active site
278137010429	substrate binding site [chemical binding]; other site
278137010430	metal binding site [ion binding]; metal-binding site
278137010431	camphor resistance protein CrcB; Provisional; Region: PRK14216
278137010432	camphor resistance protein CrcB; Provisional; Region: PRK14228
278137010433	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
278137010434	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
278137010435	acyl carrier protein; Validated; Region: PRK05883
278137010436	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
278137010437	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137010438	acyl-activating enzyme (AAE) consensus motif; other site
278137010439	AMP binding site [chemical binding]; other site
278137010440	active site
278137010441	CoA binding site [chemical binding]; other site
278137010442	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
278137010443	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
278137010444	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137010445	MULE transposase domain; Region: MULE; pfam10551
278137010446	Integrase core domain; Region: rve; pfam00665
278137010447	Integrase core domain; Region: rve_3; pfam13683
278137010448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
278137010449	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
278137010450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137010451	motif II; other site
278137010452	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137010453	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
278137010454	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
278137010455	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
278137010456	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
278137010457	nucleotide binding site [chemical binding]; other site
278137010458	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137010459	anti sigma factor interaction site; other site
278137010460	regulatory phosphorylation site [posttranslational modification]; other site
278137010461	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137010462	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137010463	dimer interface [polypeptide binding]; other site
278137010464	phosphorylation site [posttranslational modification]
278137010465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137010466	ATP binding site [chemical binding]; other site
278137010467	Mg2+ binding site [ion binding]; other site
278137010468	G-X-G motif; other site
278137010469	Response regulator receiver domain; Region: Response_reg; pfam00072
278137010470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137010471	active site
278137010472	phosphorylation site [posttranslational modification]
278137010473	intermolecular recognition site; other site
278137010474	dimerization interface [polypeptide binding]; other site
278137010475	PAS domain S-box; Region: sensory_box; TIGR00229
278137010476	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
278137010477	putative active site [active]
278137010478	heme pocket [chemical binding]; other site
278137010479	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
278137010480	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
278137010481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137010482	ATP binding site [chemical binding]; other site
278137010483	Mg2+ binding site [ion binding]; other site
278137010484	G-X-G motif; other site
278137010485	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137010486	anti sigma factor interaction site; other site
278137010487	regulatory phosphorylation site [posttranslational modification]; other site
278137010488	PAS fold; Region: PAS_3; pfam08447
278137010489	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
278137010490	putative active site [active]
278137010491	heme pocket [chemical binding]; other site
278137010492	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
278137010493	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137010494	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
278137010495	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
278137010496	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137010497	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
278137010498	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137010499	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
278137010500	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
278137010501	Cutinase; Region: Cutinase; pfam01083
278137010502	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
278137010503	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
278137010504	dimer interface [polypeptide binding]; other site
278137010505	PYR/PP interface [polypeptide binding]; other site
278137010506	TPP binding site [chemical binding]; other site
278137010507	substrate binding site [chemical binding]; other site
278137010508	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
278137010509	TPP-binding site [chemical binding]; other site
278137010510	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
278137010511	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
278137010512	AsnC family; Region: AsnC_trans_reg; pfam01037
278137010513	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
278137010514	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
278137010515	active site
278137010516	Cutinase; Region: Cutinase; pfam01083
278137010517	Protein of unknown function (DUF998); Region: DUF998; pfam06197
278137010518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137010519	NAD(P) binding site [chemical binding]; other site
278137010520	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
278137010521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137010522	active site
278137010523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
278137010524	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
278137010525	LabA_like proteins; Region: LabA_like; cd06167
278137010526	putative metal binding site [ion binding]; other site
278137010527	Uncharacterized conserved protein [Function unknown]; Region: COG1432
278137010528	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
278137010529	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137010530	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137010531	metal binding site [ion binding]; metal-binding site
278137010532	active site
278137010533	I-site; other site
278137010534	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137010535	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
278137010536	SmpB-tmRNA interface; other site
278137010537	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
278137010538	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
278137010539	FtsX-like permease family; Region: FtsX; pfam02687
278137010540	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
278137010541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137010542	Walker A/P-loop; other site
278137010543	ATP binding site [chemical binding]; other site
278137010544	Q-loop/lid; other site
278137010545	ABC transporter signature motif; other site
278137010546	Walker B; other site
278137010547	D-loop; other site
278137010548	H-loop/switch region; other site
278137010549	Mechanosensitive ion channel; Region: MS_channel; pfam00924
278137010550	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
278137010551	peptide chain release factor 2; Validated; Region: prfB; PRK00578
278137010552	This domain is found in peptide chain release factors; Region: PCRF; smart00937
278137010553	RF-1 domain; Region: RF-1; pfam00472
278137010554	ferredoxin-NADP+ reductase; Region: PLN02852
278137010555	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
278137010556	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
278137010557	active site
278137010558	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010559	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010560	active site
278137010561	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010562	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010563	active site
278137010564	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
278137010565	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137010566	molybdopterin cofactor binding site; other site
278137010567	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
278137010568	putative molybdopterin cofactor binding site; other site
278137010569	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
278137010570	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
278137010571	NADP binding site [chemical binding]; other site
278137010572	dimer interface [polypeptide binding]; other site
278137010573	Putative esterase; Region: Esterase; pfam00756
278137010574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010576	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010577	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010578	active site
278137010579	Domain of unknown function (DUF385); Region: DUF385; pfam04075
278137010580	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
278137010581	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137010582	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
278137010583	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137010584	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137010585	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
278137010586	active site
278137010587	catalytic residues [active]
278137010588	metal binding site [ion binding]; metal-binding site
278137010589	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010590	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010591	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010592	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137010593	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
278137010594	active site
278137010595	Phosphotransferase enzyme family; Region: APH; pfam01636
278137010596	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
278137010597	putative active site [active]
278137010598	putative substrate binding site [chemical binding]; other site
278137010599	ATP binding site [chemical binding]; other site
278137010600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137010601	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137010602	S-adenosylmethionine binding site [chemical binding]; other site
278137010603	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
278137010604	AAA ATPase domain; Region: AAA_16; pfam13191
278137010605	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137010606	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137010607	DNA binding residues [nucleotide binding]
278137010608	dimerization interface [polypeptide binding]; other site
278137010609	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
278137010610	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137010611	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
278137010612	triacylglycerol lipase; Region: PLN02872
278137010613	RNA helicase; Region: RNA_helicase; pfam00910
278137010614	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137010615	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137010616	DNA binding residues [nucleotide binding]
278137010617	dimerization interface [polypeptide binding]; other site
278137010618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137010619	active site
278137010620	phosphorylation site [posttranslational modification]
278137010621	intermolecular recognition site; other site
278137010622	dimerization interface [polypeptide binding]; other site
278137010623	NADH dehydrogenase subunit A; Validated; Region: PRK07928
278137010624	NADH dehydrogenase subunit B; Validated; Region: PRK06411
278137010625	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
278137010626	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
278137010627	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
278137010628	NADH dehydrogenase subunit D; Validated; Region: PRK06075
278137010629	NADH dehydrogenase subunit E; Validated; Region: PRK07539
278137010630	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
278137010631	putative dimer interface [polypeptide binding]; other site
278137010632	[2Fe-2S] cluster binding site [ion binding]; other site
278137010633	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
278137010634	SLBB domain; Region: SLBB; pfam10531
278137010635	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
278137010636	NADH dehydrogenase subunit G; Validated; Region: PRK07860
278137010637	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137010638	catalytic loop [active]
278137010639	iron binding site [ion binding]; other site
278137010640	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
278137010641	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137010642	molybdopterin cofactor binding site; other site
278137010643	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
278137010644	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
278137010645	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
278137010646	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
278137010647	4Fe-4S binding domain; Region: Fer4; pfam00037
278137010648	4Fe-4S binding domain; Region: Fer4; pfam00037
278137010649	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
278137010650	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
278137010651	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
278137010652	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
278137010653	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
278137010654	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
278137010655	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
278137010656	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
278137010657	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
278137010658	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
278137010659	enoyl-CoA hydratase; Provisional; Region: PRK06190
278137010660	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137010661	substrate binding site [chemical binding]; other site
278137010662	oxyanion hole (OAH) forming residues; other site
278137010663	trimer interface [polypeptide binding]; other site
278137010664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010666	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
278137010667	putative active site [active]
278137010668	putative substrate binding site [chemical binding]; other site
278137010669	ATP binding site [chemical binding]; other site
278137010670	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137010671	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137010672	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
278137010673	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137010674	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
278137010675	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
278137010676	NAD(P) binding site [chemical binding]; other site
278137010677	AAA ATPase domain; Region: AAA_16; pfam13191
278137010678	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137010679	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137010680	DNA binding residues [nucleotide binding]
278137010681	dimerization interface [polypeptide binding]; other site
278137010682	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
278137010683	homotetramer interface [polypeptide binding]; other site
278137010684	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137010685	NAD binding site [chemical binding]; other site
278137010686	homodimer interface [polypeptide binding]; other site
278137010687	active site
278137010688	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137010689	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137010690	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137010691	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
278137010692	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137010693	classical (c) SDRs; Region: SDR_c; cd05233
278137010694	NAD(P) binding site [chemical binding]; other site
278137010695	active site
278137010696	Isochorismatase family; Region: Isochorismatase; pfam00857
278137010697	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
278137010698	catalytic triad [active]
278137010699	conserved cis-peptide bond; other site
278137010700	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010701	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010702	active site
278137010703	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
278137010704	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
278137010705	NAD(P) binding site [chemical binding]; other site
278137010706	catalytic residues [active]
278137010707	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137010708	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
278137010709	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137010710	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137010711	metal binding site [ion binding]; metal-binding site
278137010712	active site
278137010713	I-site; other site
278137010714	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137010715	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
278137010716	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
278137010717	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137010718	NAD(P) binding site [chemical binding]; other site
278137010719	PE-PPE domain; Region: PE-PPE; pfam08237
278137010720	PAS fold; Region: PAS_2; pfam08446
278137010721	GAF domain; Region: GAF; pfam01590
278137010722	Phytochrome region; Region: PHY; pfam00360
278137010723	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
278137010724	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137010725	anti sigma factor interaction site; other site
278137010726	regulatory phosphorylation site [posttranslational modification]; other site
278137010727	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137010728	GAF domain; Region: GAF; pfam01590
278137010729	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137010730	GAF domain; Region: GAF_3; pfam13492
278137010731	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
278137010732	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
278137010733	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
278137010734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
278137010735	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137010736	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137010737	membrane-bound complex binding site; other site
278137010738	hinge residues; other site
278137010739	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
278137010740	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137010741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137010742	putative substrate translocation pore; other site
278137010743	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
278137010744	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
278137010745	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
278137010746	lipid-transfer protein; Provisional; Region: PRK06059
278137010747	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
278137010748	active site
278137010749	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137010750	mce related protein; Region: MCE; pfam02470
278137010751	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137010752	mce related protein; Region: MCE; pfam02470
278137010753	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137010754	mce related protein; Region: MCE; pfam02470
278137010755	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137010756	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137010757	mce related protein; Region: MCE; pfam02470
278137010758	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
278137010759	mce related protein; Region: MCE; pfam02470
278137010760	mce related protein; Region: MCE; pfam02470
278137010761	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
278137010762	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137010763	Permease; Region: Permease; pfam02405
278137010764	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
278137010765	Permease; Region: Permease; pfam02405
278137010766	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137010767	classical (c) SDRs; Region: SDR_c; cd05233
278137010768	NAD(P) binding site [chemical binding]; other site
278137010769	active site
278137010770	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137010771	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137010772	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137010773	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
278137010774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137010775	NAD(P) binding site [chemical binding]; other site
278137010776	active site
278137010777	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137010778	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137010779	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137010780	catalytic loop [active]
278137010781	iron binding site [ion binding]; other site
278137010782	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010783	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010784	active site
278137010785	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
278137010786	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
278137010787	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
278137010788	active site
278137010789	Fe binding site [ion binding]; other site
278137010790	hypothetical protein; Validated; Region: PRK07121
278137010791	Transcriptional regulator [Transcription]; Region: IclR; COG1414
278137010792	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
278137010793	Bacterial transcriptional regulator; Region: IclR; pfam01614
278137010794	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137010795	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137010796	substrate binding pocket [chemical binding]; other site
278137010797	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137010798	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
278137010799	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
278137010800	active site
278137010801	FMN binding site [chemical binding]; other site
278137010802	substrate binding site [chemical binding]; other site
278137010803	putative catalytic residue [active]
278137010804	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
278137010805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137010806	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
278137010807	NAD(P) binding site [chemical binding]; other site
278137010808	active site
278137010809	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137010810	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137010811	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137010812	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137010813	active site
278137010814	acyl-CoA synthetase; Validated; Region: PRK08316
278137010815	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137010816	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
278137010817	acyl-activating enzyme (AAE) consensus motif; other site
278137010818	putative AMP binding site [chemical binding]; other site
278137010819	putative active site [active]
278137010820	putative CoA binding site [chemical binding]; other site
278137010821	classical (c) SDRs; Region: SDR_c; cd05233
278137010822	NAD(P) binding site [chemical binding]; other site
278137010823	active site
278137010824	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137010825	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137010826	hypothetical protein; Validated; Region: PRK07121
278137010827	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
278137010828	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
278137010829	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
278137010830	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845
278137010831	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137010832	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
278137010833	Predicted transcriptional regulators [Transcription]; Region: COG1695
278137010834	Transcriptional regulator PadR-like family; Region: PadR; cl17335
278137010835	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
278137010836	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
278137010837	CoenzymeA binding site [chemical binding]; other site
278137010838	subunit interaction site [polypeptide binding]; other site
278137010839	PHB binding site; other site
278137010840	GAF domain; Region: GAF; pfam01590
278137010841	GAF domain; Region: GAF_2; pfam13185
278137010842	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137010843	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010844	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010845	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
278137010846	Subunit I/III interface [polypeptide binding]; other site
278137010847	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137010848	catalytic core [active]
278137010849	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
278137010850	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
278137010851	ligand binding site [chemical binding]; other site
278137010852	heat shock protein 90; Provisional; Region: PRK05218
278137010853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137010854	ATP binding site [chemical binding]; other site
278137010855	Mg2+ binding site [ion binding]; other site
278137010856	G-X-G motif; other site
278137010857	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
278137010858	FAD binding domain; Region: FAD_binding_4; pfam01565
278137010859	DNA binding site [nucleotide binding]
278137010860	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
278137010861	Bacterial transcriptional activator domain; Region: BTAD; smart01043
278137010862	Predicted ATPase [General function prediction only]; Region: COG3899
278137010863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137010864	Walker A motif; other site
278137010865	ATP binding site [chemical binding]; other site
278137010866	hypothetical protein; Validated; Region: PRK00068
278137010867	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
278137010868	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
278137010869	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
278137010870	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
278137010871	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
278137010872	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
278137010873	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
278137010874	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
278137010875	ABC1 family; Region: ABC1; pfam03109
278137010876	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
278137010877	active site
278137010878	ATP binding site [chemical binding]; other site
278137010879	Transcription factor WhiB; Region: Whib; pfam02467
278137010880	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
278137010881	Family description; Region: UvrD_C_2; pfam13538
278137010882	HRDC domain; Region: HRDC; pfam00570
278137010883	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
278137010884	catalytic residues [active]
278137010885	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
278137010886	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
278137010887	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
278137010888	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
278137010889	putative NADH binding site [chemical binding]; other site
278137010890	putative active site [active]
278137010891	nudix motif; other site
278137010892	putative metal binding site [ion binding]; other site
278137010893	Ion channel; Region: Ion_trans_2; pfam07885
278137010894	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
278137010895	TrkA-N domain; Region: TrkA_N; pfam02254
278137010896	Predicted membrane protein [Function unknown]; Region: COG4270
278137010897	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
278137010898	Part of AAA domain; Region: AAA_19; pfam13245
278137010899	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
278137010900	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
278137010901	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
278137010902	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137010903	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
278137010904	catalytic site [active]
278137010905	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
278137010906	active site
278137010907	DNA binding site [nucleotide binding]
278137010908	TIGR02569 family protein; Region: TIGR02569_actnb
278137010909	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
278137010910	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
278137010911	ATP binding site [chemical binding]; other site
278137010912	substrate interface [chemical binding]; other site
278137010913	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
278137010914	active site residue [active]
278137010915	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
278137010916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137010917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137010918	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
278137010919	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
278137010920	dinuclear metal binding motif [ion binding]; other site
278137010921	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
278137010922	DEAD-like helicases superfamily; Region: DEXDc; smart00487
278137010923	ATP binding site [chemical binding]; other site
278137010924	Mg++ binding site [ion binding]; other site
278137010925	motif III; other site
278137010926	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137010927	nucleotide binding region [chemical binding]; other site
278137010928	ATP-binding site [chemical binding]; other site
278137010929	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
278137010930	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
278137010931	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137010932	P-loop; other site
278137010933	Magnesium ion binding site [ion binding]; other site
278137010934	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
278137010935	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137010936	Magnesium ion binding site [ion binding]; other site
278137010937	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137010938	catalytic core [active]
278137010939	isochorismate synthase DhbC; Validated; Region: PRK06923
278137010940	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
278137010941	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137010942	Coenzyme A binding pocket [chemical binding]; other site
278137010943	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
278137010944	Dehydroquinase class II; Region: DHquinase_II; pfam01220
278137010945	active site
278137010946	trimer interface [polypeptide binding]; other site
278137010947	dimer interface [polypeptide binding]; other site
278137010948	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
278137010949	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
278137010950	Transcription factor WhiB; Region: Whib; pfam02467
278137010951	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
278137010952	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
278137010953	Histidine kinase; Region: HisKA_2; pfam07568
278137010954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137010955	ATP binding site [chemical binding]; other site
278137010956	Mg2+ binding site [ion binding]; other site
278137010957	G-X-G motif; other site
278137010958	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
278137010959	carboxyltransferase (CT) interaction site; other site
278137010960	biotinylation site [posttranslational modification]; other site
278137010961	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
278137010962	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
278137010963	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137010964	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137010965	DNA binding residues [nucleotide binding]
278137010966	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
278137010967	putative deacylase active site [active]
278137010968	short chain dehydrogenase; Provisional; Region: PRK08278
278137010969	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
278137010970	NAD(P) binding site [chemical binding]; other site
278137010971	homodimer interface [polypeptide binding]; other site
278137010972	active site
278137010973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137010974	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
278137010975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137010976	S-adenosylmethionine binding site [chemical binding]; other site
278137010977	Uncharacterized conserved protein [Function unknown]; Region: COG2135
278137010978	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
278137010979	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
278137010980	hinge; other site
278137010981	active site
278137010982	Predicted GTPases [General function prediction only]; Region: COG1162
278137010983	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
278137010984	GTPase/Zn-binding domain interface [polypeptide binding]; other site
278137010985	GTP/Mg2+ binding site [chemical binding]; other site
278137010986	G4 box; other site
278137010987	G5 box; other site
278137010988	G1 box; other site
278137010989	Switch I region; other site
278137010990	G2 box; other site
278137010991	G3 box; other site
278137010992	Switch II region; other site
278137010993	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
278137010994	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
278137010995	active site
278137010996	catalytic tetrad [active]
278137010997	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
278137010998	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
278137010999	putative di-iron ligands [ion binding]; other site
278137011000	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
278137011001	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
278137011002	FAD binding pocket [chemical binding]; other site
278137011003	FAD binding motif [chemical binding]; other site
278137011004	phosphate binding motif [ion binding]; other site
278137011005	beta-alpha-beta structure motif; other site
278137011006	NAD binding pocket [chemical binding]; other site
278137011007	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137011008	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
278137011009	catalytic loop [active]
278137011010	iron binding site [ion binding]; other site
278137011011	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
278137011012	BCCT family transporter; Region: BCCT; pfam02028
278137011013	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
278137011014	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
278137011015	ATP binding site [chemical binding]; other site
278137011016	putative Mg++ binding site [ion binding]; other site
278137011017	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
278137011018	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
278137011019	30S subunit binding site; other site
278137011020	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
278137011021	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
278137011022	iron-sulfur cluster [ion binding]; other site
278137011023	[2Fe-2S] cluster binding site [ion binding]; other site
278137011024	lipoprotein LpqB; Provisional; Region: PRK13616
278137011025	Sporulation and spore germination; Region: Germane; pfam10646
278137011026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137011027	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
278137011028	dimerization interface [polypeptide binding]; other site
278137011029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137011030	dimer interface [polypeptide binding]; other site
278137011031	phosphorylation site [posttranslational modification]
278137011032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137011033	ATP binding site [chemical binding]; other site
278137011034	Mg2+ binding site [ion binding]; other site
278137011035	G-X-G motif; other site
278137011036	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137011037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137011038	active site
278137011039	phosphorylation site [posttranslational modification]
278137011040	intermolecular recognition site; other site
278137011041	dimerization interface [polypeptide binding]; other site
278137011042	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137011043	DNA binding site [nucleotide binding]
278137011044	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
278137011045	TMP-binding site; other site
278137011046	ATP-binding site [chemical binding]; other site
278137011047	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137011048	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
278137011049	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
278137011050	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
278137011051	homotetramer interface [polypeptide binding]; other site
278137011052	ligand binding site [chemical binding]; other site
278137011053	catalytic site [active]
278137011054	NAD binding site [chemical binding]; other site
278137011055	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137011056	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011057	Rubredoxin [Energy production and conversion]; Region: COG1773
278137011058	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
278137011059	iron binding site [ion binding]; other site
278137011060	Rubredoxin [Energy production and conversion]; Region: COG1773
278137011061	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
278137011062	iron binding site [ion binding]; other site
278137011063	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
278137011064	Fatty acid desaturase; Region: FA_desaturase; pfam00487
278137011065	Di-iron ligands [ion binding]; other site
278137011066	amino acid transporter; Region: 2A0306; TIGR00909
278137011067	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
278137011068	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
278137011069	hypothetical protein; Provisional; Region: PRK07236
278137011070	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
278137011071	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
278137011072	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
278137011073	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
278137011074	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
278137011075	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
278137011076	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
278137011077	active site
278137011078	substrate binding site [chemical binding]; other site
278137011079	metal binding site [ion binding]; metal-binding site
278137011080	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
278137011081	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
278137011082	Transcription factor WhiB; Region: Whib; pfam02467
278137011083	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
278137011084	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
278137011085	dimer interface [polypeptide binding]; other site
278137011086	phosphate binding site [ion binding]; other site
278137011087	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
278137011088	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
278137011089	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
278137011090	putative FMN binding site [chemical binding]; other site
278137011091	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
278137011092	nudix motif; other site
278137011093	PAS domain S-box; Region: sensory_box; TIGR00229
278137011094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137011095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137011096	metal binding site [ion binding]; metal-binding site
278137011097	active site
278137011098	I-site; other site
278137011099	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
278137011100	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
278137011101	active site
278137011102	Substrate binding site; other site
278137011103	Mg++ binding site; other site
278137011104	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
278137011105	putative CoA binding site [chemical binding]; other site
278137011106	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
278137011107	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
278137011108	Probable Catalytic site; other site
278137011109	metal-binding site
278137011110	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
278137011111	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
278137011112	NADP binding site [chemical binding]; other site
278137011113	active site
278137011114	putative substrate binding site [chemical binding]; other site
278137011115	Transcriptional regulator [Transcription]; Region: LytR; COG1316
278137011116	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
278137011117	TIGR03089 family protein; Region: TIGR03089
278137011118	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
278137011119	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
278137011120	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
278137011121	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137011122	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
278137011123	FAD binding site [chemical binding]; other site
278137011124	homotetramer interface [polypeptide binding]; other site
278137011125	substrate binding pocket [chemical binding]; other site
278137011126	catalytic base [active]
278137011127	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137011128	GAF domain; Region: GAF; pfam01590
278137011129	AIR carboxylase; Region: AIRC; pfam00731
278137011130	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
278137011131	ATP-grasp domain; Region: ATP-grasp; pfam02222
278137011132	Predicted membrane protein [Function unknown]; Region: COG2246
278137011133	GtrA-like protein; Region: GtrA; pfam04138
278137011134	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
278137011135	putative active site [active]
278137011136	Bacterial PH domain; Region: DUF304; pfam03703
278137011137	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
278137011138	Right handed beta helix region; Region: Beta_helix; pfam13229
278137011139	hypothetical protein; Provisional; Region: PRK07208
278137011140	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137011141	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
278137011142	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
278137011143	catalytic residue [active]
278137011144	putative FPP diphosphate  binding site; other site
278137011145	putative FPP binding hydrophobic cleft; other site
278137011146	dimer interface [polypeptide binding]; other site
278137011147	putative IPP diphosphate binding site; other site
278137011148	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
278137011149	Bacterial sugar transferase; Region: Bac_transf; pfam02397
278137011150	Low molecular weight phosphatase family; Region: LMWPc; cd00115
278137011151	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
278137011152	active site
278137011153	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
278137011154	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
278137011155	substrate binding site; other site
278137011156	tetramer interface; other site
278137011157	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
278137011158	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
278137011159	NAD binding site [chemical binding]; other site
278137011160	substrate binding site [chemical binding]; other site
278137011161	homodimer interface [polypeptide binding]; other site
278137011162	active site
278137011163	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
278137011164	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
278137011165	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
278137011166	NADP binding site [chemical binding]; other site
278137011167	active site
278137011168	putative substrate binding site [chemical binding]; other site
278137011169	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137011170	Transposase; Region: HTH_Tnp_1; cl17663
278137011171	putative transposase OrfB; Reviewed; Region: PHA02517
278137011172	HTH-like domain; Region: HTH_21; pfam13276
278137011173	Integrase core domain; Region: rve; pfam00665
278137011174	Integrase core domain; Region: rve_3; pfam13683
278137011175	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137011176	putative transposase OrfB; Reviewed; Region: PHA02517
278137011177	Integrase core domain; Region: rve; pfam00665
278137011178	Integrase core domain; Region: rve_3; pfam13683
278137011179	Transposase; Region: HTH_Tnp_1; cl17663
278137011180	HTH-like domain; Region: HTH_21; pfam13276
278137011181	Integrase core domain; Region: rve; pfam00665
278137011182	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137011183	Helix-turn-helix domain; Region: HTH_28; pfam13518
278137011184	Winged helix-turn helix; Region: HTH_29; pfam13551
278137011185	Homeodomain-like domain; Region: HTH_32; pfam13565
278137011186	Integrase core domain; Region: rve; pfam00665
278137011187	Integrase core domain; Region: rve_3; pfam13683
278137011188	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
278137011189	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
278137011190	AAA domain; Region: AAA_22; pfam13401
278137011191	ATP-binding site [chemical binding]; other site
278137011192	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
278137011193	Transposase; Region: HTH_Tnp_1; cl17663
278137011194	putative transposase OrfB; Reviewed; Region: PHA02517
278137011195	HTH-like domain; Region: HTH_21; pfam13276
278137011196	Integrase core domain; Region: rve; pfam00665
278137011197	Integrase core domain; Region: rve_3; cl15866
278137011198	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137011199	putative transposase OrfB; Reviewed; Region: PHA02517
278137011200	HTH-like domain; Region: HTH_21; pfam13276
278137011201	Integrase core domain; Region: rve; pfam00665
278137011202	Integrase core domain; Region: rve_3; pfam13683
278137011203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137011204	Transposase; Region: HTH_Tnp_1; pfam01527
278137011205	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
278137011206	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137011207	putative transposase OrfB; Reviewed; Region: PHA02517
278137011208	HTH-like domain; Region: HTH_21; pfam13276
278137011209	Integrase core domain; Region: rve; pfam00665
278137011210	Integrase core domain; Region: rve_3; pfam13683
278137011211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137011212	Transposase; Region: HTH_Tnp_1; cl17663
278137011213	Transposase; Region: HTH_Tnp_1; pfam01527
278137011214	putative transposase OrfB; Reviewed; Region: PHA02517
278137011215	HTH-like domain; Region: HTH_21; pfam13276
278137011216	Integrase core domain; Region: rve; pfam00665
278137011217	Integrase core domain; Region: rve_3; pfam13683
278137011218	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137011219	S-adenosylmethionine binding site [chemical binding]; other site
278137011220	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137011221	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137011222	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137011223	MULE transposase domain; Region: MULE; pfam10551
278137011224	Transposase; Region: HTH_Tnp_1; pfam01527
278137011225	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137011226	putative transposase OrfB; Reviewed; Region: PHA02517
278137011227	HTH-like domain; Region: HTH_21; pfam13276
278137011228	Integrase core domain; Region: rve; pfam00665
278137011229	Integrase core domain; Region: rve_3; pfam13683
278137011230	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137011231	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137011232	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
278137011233	putative ADP-binding pocket [chemical binding]; other site
278137011234	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
278137011235	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137011236	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
278137011237	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
278137011238	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
278137011239	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
278137011240	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
278137011241	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
278137011242	Probable Catalytic site; other site
278137011243	metal-binding site
278137011244	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137011245	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137011246	active site
278137011247	catalytic residues [active]
278137011248	DNA binding site [nucleotide binding]
278137011249	Int/Topo IB signature motif; other site
278137011250	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137011251	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137011252	active site
278137011253	DNA binding site [nucleotide binding]
278137011254	Int/Topo IB signature motif; other site
278137011255	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137011256	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137011257	MULE transposase domain; Region: MULE; pfam10551
278137011258	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
278137011259	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
278137011260	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
278137011261	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137011262	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137011263	O-Antigen ligase; Region: Wzy_C; pfam04932
278137011264	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137011265	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137011266	MULE transposase domain; Region: MULE; pfam10551
278137011267	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137011268	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137011269	Methyltransferase domain; Region: Methyltransf_12; pfam08242
278137011270	Transposase; Region: HTH_Tnp_1; pfam01527
278137011271	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137011272	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137011273	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137011274	active site
278137011275	DNA binding site [nucleotide binding]
278137011276	Int/Topo IB signature motif; other site
278137011277	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137011278	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137011279	active site
278137011280	catalytic residues [active]
278137011281	DNA binding site [nucleotide binding]
278137011282	Int/Topo IB signature motif; other site
278137011283	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137011284	MULE transposase domain; Region: MULE; pfam10551
278137011285	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137011286	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137011287	S-adenosylmethionine binding site [chemical binding]; other site
278137011288	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137011289	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137011290	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137011291	active site
278137011292	catalytic residues [active]
278137011293	DNA binding site [nucleotide binding]
278137011294	Int/Topo IB signature motif; other site
278137011295	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137011296	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137011297	active site
278137011298	DNA binding site [nucleotide binding]
278137011299	Int/Topo IB signature motif; other site
278137011300	putative transposase OrfB; Reviewed; Region: PHA02517
278137011301	HTH-like domain; Region: HTH_21; pfam13276
278137011302	Integrase core domain; Region: rve; pfam00665
278137011303	Integrase core domain; Region: rve_3; cl15866
278137011304	Transposase; Region: HTH_Tnp_1; cl17663
278137011305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137011306	Chain length determinant protein; Region: Wzz; cl15801
278137011307	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
278137011308	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
278137011309	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
278137011310	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
278137011311	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
278137011312	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
278137011313	Maf-like protein; Region: Maf; pfam02545
278137011314	putative active site [active]
278137011315	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
278137011316	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
278137011317	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
278137011318	active site residue [active]
278137011319	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
278137011320	active site residue [active]
278137011321	Fe-S metabolism associated domain; Region: SufE; cl00951
278137011322	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137011323	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137011324	metal binding site [ion binding]; metal-binding site
278137011325	active site
278137011326	I-site; other site
278137011327	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
278137011328	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
278137011329	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
278137011330	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
278137011331	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
278137011332	carboxyltransferase (CT) interaction site; other site
278137011333	biotinylation site [posttranslational modification]; other site
278137011334	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
278137011335	Ligand binding site; other site
278137011336	metal-binding site
278137011337	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137011338	anti sigma factor interaction site; other site
278137011339	regulatory phosphorylation site [posttranslational modification]; other site
278137011340	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
278137011341	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137011342	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
278137011343	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137011344	DNA binding residues [nucleotide binding]
278137011345	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
278137011346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
278137011347	CsbD-like; Region: CsbD; cl17424
278137011348	Restriction endonuclease; Region: Mrr_cat; pfam04471
278137011349	L-lysine aminotransferase; Provisional; Region: PRK08297
278137011350	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137011351	inhibitor-cofactor binding pocket; inhibition site
278137011352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137011353	catalytic residue [active]
278137011354	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
278137011355	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
278137011356	AsnC family; Region: AsnC_trans_reg; pfam01037
278137011357	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
278137011358	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
278137011359	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137011360	tetrameric interface [polypeptide binding]; other site
278137011361	NAD binding site [chemical binding]; other site
278137011362	catalytic residues [active]
278137011363	classical (c) SDRs; Region: SDR_c; cd05233
278137011364	short chain dehydrogenase; Provisional; Region: PRK05650
278137011365	NAD(P) binding site [chemical binding]; other site
278137011366	active site
278137011367	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137011368	Cytochrome P450; Region: p450; cl12078
278137011369	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137011370	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011371	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
278137011372	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137011373	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137011374	DNA binding residues [nucleotide binding]
278137011375	dimerization interface [polypeptide binding]; other site
278137011376	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137011377	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
278137011378	ATP binding site [chemical binding]; other site
278137011379	putative Mg++ binding site [ion binding]; other site
278137011380	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137011381	nucleotide binding region [chemical binding]; other site
278137011382	ATP-binding site [chemical binding]; other site
278137011383	DEAD/H associated; Region: DEAD_assoc; pfam08494
278137011384	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
278137011385	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
278137011386	putative DNA binding site [nucleotide binding]; other site
278137011387	catalytic residue [active]
278137011388	putative H2TH interface [polypeptide binding]; other site
278137011389	putative catalytic residues [active]
278137011390	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
278137011391	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
278137011392	Fatty acid desaturase; Region: FA_desaturase; pfam00487
278137011393	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
278137011394	putative di-iron ligands [ion binding]; other site
278137011395	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
278137011396	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
278137011397	FAD binding pocket [chemical binding]; other site
278137011398	FAD binding motif [chemical binding]; other site
278137011399	phosphate binding motif [ion binding]; other site
278137011400	beta-alpha-beta structure motif; other site
278137011401	NAD binding pocket [chemical binding]; other site
278137011402	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137011403	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
278137011404	catalytic loop [active]
278137011405	iron binding site [ion binding]; other site
278137011406	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
278137011407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011408	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137011409	substrate binding site [chemical binding]; other site
278137011410	oxyanion hole (OAH) forming residues; other site
278137011411	trimer interface [polypeptide binding]; other site
278137011412	short chain dehydrogenase; Provisional; Region: PRK07035
278137011413	classical (c) SDRs; Region: SDR_c; cd05233
278137011414	NAD(P) binding site [chemical binding]; other site
278137011415	active site
278137011416	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
278137011417	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
278137011418	active site
278137011419	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
278137011420	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
278137011421	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137011422	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137011423	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
278137011424	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
278137011425	putative active site pocket [active]
278137011426	dimerization interface [polypeptide binding]; other site
278137011427	putative catalytic residue [active]
278137011428	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
278137011429	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
278137011430	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
278137011431	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
278137011432	metal binding site [ion binding]; metal-binding site
278137011433	putative dimer interface [polypeptide binding]; other site
278137011434	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
278137011435	amidohydrolase; Region: amidohydrolases; TIGR01891
278137011436	metal binding site [ion binding]; metal-binding site
278137011437	purine nucleoside phosphorylase; Provisional; Region: PRK08202
278137011438	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
278137011439	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
278137011440	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
278137011441	MarR family; Region: MarR_2; pfam12802
278137011442	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
278137011443	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
278137011444	active site
278137011445	substrate binding site [chemical binding]; other site
278137011446	metal binding site [ion binding]; metal-binding site
278137011447	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
278137011448	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137011449	Coenzyme A binding pocket [chemical binding]; other site
278137011450	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
278137011451	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137011452	inhibitor-cofactor binding pocket; inhibition site
278137011453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137011454	catalytic residue [active]
278137011455	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
278137011456	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
278137011457	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137011458	active site
278137011459	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137011460	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137011461	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137011462	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137011463	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
278137011464	adenosine deaminase; Provisional; Region: PRK09358
278137011465	active site
278137011466	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
278137011467	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
278137011468	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
278137011469	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
278137011470	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
278137011471	active site
278137011472	catalytic motif [active]
278137011473	Zn binding site [ion binding]; other site
278137011474	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
278137011475	putative Iron-sulfur protein interface [polypeptide binding]; other site
278137011476	putative proximal heme binding site [chemical binding]; other site
278137011477	putative SdhD-like interface [polypeptide binding]; other site
278137011478	putative distal heme binding site [chemical binding]; other site
278137011479	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
278137011480	putative Iron-sulfur protein interface [polypeptide binding]; other site
278137011481	putative proximal heme binding site [chemical binding]; other site
278137011482	putative SdhC-like subunit interface [polypeptide binding]; other site
278137011483	putative distal heme binding site [chemical binding]; other site
278137011484	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
278137011485	L-aspartate oxidase; Provisional; Region: PRK06175
278137011486	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
278137011487	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
278137011488	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
278137011489	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137011490	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
278137011491	CGNR zinc finger; Region: zf-CGNR; pfam11706
278137011492	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
278137011493	Domain of unknown function DUF20; Region: UPF0118; pfam01594
278137011494	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
278137011495	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
278137011496	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137011497	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137011498	DNA binding residues [nucleotide binding]
278137011499	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137011500	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
278137011501	putative transposase OrfB; Reviewed; Region: PHA02517
278137011502	HTH-like domain; Region: HTH_21; pfam13276
278137011503	Integrase core domain; Region: rve; pfam00665
278137011504	Integrase core domain; Region: rve_3; pfam13683
278137011505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137011506	Transposase; Region: HTH_Tnp_1; pfam01527
278137011507	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
278137011508	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
278137011509	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
278137011510	Zn binding site [ion binding]; other site
278137011511	HTH-like domain; Region: HTH_21; pfam13276
278137011512	Integrase core domain; Region: rve; pfam00665
278137011513	Integrase core domain; Region: rve_3; pfam13683
278137011514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137011515	Transposase; Region: HTH_Tnp_1; pfam01527
278137011516	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137011517	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137011518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137011519	Walker A motif; other site
278137011520	ATP binding site [chemical binding]; other site
278137011521	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137011522	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137011523	DNA binding residues [nucleotide binding]
278137011524	dimerization interface [polypeptide binding]; other site
278137011525	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
278137011526	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
278137011527	NAD(P) binding site [chemical binding]; other site
278137011528	catalytic residues [active]
278137011529	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
278137011530	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
278137011531	AsnC family; Region: AsnC_trans_reg; pfam01037
278137011532	hypothetical protein; Provisional; Region: PRK06541
278137011533	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137011534	inhibitor-cofactor binding pocket; inhibition site
278137011535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137011536	catalytic residue [active]
278137011537	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
278137011538	Strictosidine synthase; Region: Str_synth; pfam03088
278137011539	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137011540	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137011541	DNA binding residues [nucleotide binding]
278137011542	dimerization interface [polypeptide binding]; other site
278137011543	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
278137011544	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137011545	acyl-activating enzyme (AAE) consensus motif; other site
278137011546	AMP binding site [chemical binding]; other site
278137011547	active site
278137011548	CoA binding site [chemical binding]; other site
278137011549	AMP-binding domain protein; Validated; Region: PRK08315
278137011550	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137011551	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
278137011552	acyl-activating enzyme (AAE) consensus motif; other site
278137011553	putative AMP binding site [chemical binding]; other site
278137011554	putative active site [active]
278137011555	putative CoA binding site [chemical binding]; other site
278137011556	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
278137011557	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
278137011558	putative active site [active]
278137011559	putative metal binding site [ion binding]; other site
278137011560	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
278137011561	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
278137011562	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
278137011563	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
278137011564	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
278137011565	active site
278137011566	HIGH motif; other site
278137011567	dimer interface [polypeptide binding]; other site
278137011568	KMSKS motif; other site
278137011569	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
278137011570	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
278137011571	putative active site [active]
278137011572	putative catalytic site [active]
278137011573	putative DNA binding site [nucleotide binding]; other site
278137011574	putative phosphate binding site [ion binding]; other site
278137011575	metal binding site A [ion binding]; metal-binding site
278137011576	putative AP binding site [nucleotide binding]; other site
278137011577	putative metal binding site B [ion binding]; other site
278137011578	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137011579	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
278137011580	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
278137011581	homodimer interface [polypeptide binding]; other site
278137011582	substrate-cofactor binding pocket; other site
278137011583	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137011584	catalytic residue [active]
278137011585	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
278137011586	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
278137011587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137011588	S-adenosylmethionine binding site [chemical binding]; other site
278137011589	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
278137011590	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
278137011591	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
278137011592	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
278137011593	homodimer interface [polypeptide binding]; other site
278137011594	NADP binding site [chemical binding]; other site
278137011595	substrate binding site [chemical binding]; other site
278137011596	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
278137011597	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
278137011598	active site
278137011599	FMN binding site [chemical binding]; other site
278137011600	substrate binding site [chemical binding]; other site
278137011601	putative catalytic residue [active]
278137011602	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137011603	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011604	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
278137011605	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
278137011606	phosphopeptide binding site; other site
278137011607	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
278137011608	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
278137011609	phosphopeptide binding site; other site
278137011610	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
278137011611	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
278137011612	Walker A/P-loop; other site
278137011613	ATP binding site [chemical binding]; other site
278137011614	Q-loop/lid; other site
278137011615	ABC transporter signature motif; other site
278137011616	Walker B; other site
278137011617	D-loop; other site
278137011618	H-loop/switch region; other site
278137011619	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
278137011620	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
278137011621	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
278137011622	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
278137011623	heme-binding site [chemical binding]; other site
278137011624	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
278137011625	FAD binding pocket [chemical binding]; other site
278137011626	FAD binding motif [chemical binding]; other site
278137011627	phosphate binding motif [ion binding]; other site
278137011628	beta-alpha-beta structure motif; other site
278137011629	NAD binding pocket [chemical binding]; other site
278137011630	Heme binding  pocket [chemical binding]; other site
278137011631	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
278137011632	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
278137011633	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
278137011634	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
278137011635	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
278137011636	G1 box; other site
278137011637	GTP/Mg2+ binding site [chemical binding]; other site
278137011638	G2 box; other site
278137011639	Switch I region; other site
278137011640	G3 box; other site
278137011641	Switch II region; other site
278137011642	G4 box; other site
278137011643	G5 box; other site
278137011644	Protein of unknown function (DUF742); Region: DUF742; pfam05331
278137011645	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
278137011646	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
278137011647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137011648	ATP binding site [chemical binding]; other site
278137011649	Mg2+ binding site [ion binding]; other site
278137011650	G-X-G motif; other site
278137011651	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
278137011652	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
278137011653	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
278137011654	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
278137011655	FMN binding site [chemical binding]; other site
278137011656	dimer interface [polypeptide binding]; other site
278137011657	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
278137011658	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
278137011659	active site
278137011660	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
278137011661	generic binding surface II; other site
278137011662	generic binding surface I; other site
278137011663	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
278137011664	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137011665	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137011666	metal binding site [ion binding]; metal-binding site
278137011667	active site
278137011668	I-site; other site
278137011669	enoyl-CoA hydratase; Region: PLN02864
278137011670	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137011671	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
278137011672	dimer interaction site [polypeptide binding]; other site
278137011673	substrate-binding tunnel; other site
278137011674	active site
278137011675	catalytic site [active]
278137011676	substrate binding site [chemical binding]; other site
278137011677	short chain dehydrogenase; Provisional; Region: PRK07201
278137011678	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
278137011679	putative NAD(P) binding site [chemical binding]; other site
278137011680	active site
278137011681	putative substrate binding site [chemical binding]; other site
278137011682	classical (c) SDRs; Region: SDR_c; cd05233
278137011683	NAD(P) binding site [chemical binding]; other site
278137011684	active site
278137011685	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
278137011686	active site
278137011687	DNA Polymerase Y-family; Region: PolY_like; cd03468
278137011688	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
278137011689	DNA binding site [nucleotide binding]
278137011690	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
278137011691	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
278137011692	DNA binding residues [nucleotide binding]
278137011693	putative dimer interface [polypeptide binding]; other site
278137011694	GMP synthase; Reviewed; Region: guaA; PRK00074
278137011695	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
278137011696	AMP/PPi binding site [chemical binding]; other site
278137011697	candidate oxyanion hole; other site
278137011698	catalytic triad [active]
278137011699	potential glutamine specificity residues [chemical binding]; other site
278137011700	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
278137011701	ATP Binding subdomain [chemical binding]; other site
278137011702	Ligand Binding sites [chemical binding]; other site
278137011703	Dimerization subdomain; other site
278137011704	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137011705	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
278137011706	DNA binding residues [nucleotide binding]
278137011707	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
278137011708	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
278137011709	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137011710	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
278137011711	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011712	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
278137011713	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
278137011714	phosphate binding site [ion binding]; other site
278137011715	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
278137011716	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
278137011717	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
278137011718	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
278137011719	active site
278137011720	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
278137011721	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137011722	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137011723	DNA binding residues [nucleotide binding]
278137011724	Transcription factor WhiB; Region: Whib; pfam02467
278137011725	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
278137011726	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
278137011727	thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887
278137011728	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
278137011729	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
278137011730	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
278137011731	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
278137011732	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
278137011733	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
278137011734	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
278137011735	ring oligomerisation interface [polypeptide binding]; other site
278137011736	ATP/Mg binding site [chemical binding]; other site
278137011737	stacking interactions; other site
278137011738	hinge regions; other site
278137011739	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
278137011740	oligomerisation interface [polypeptide binding]; other site
278137011741	mobile loop; other site
278137011742	roof hairpin; other site
278137011743	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137011744	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137011745	active site
278137011746	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137011747	UGMP family protein; Validated; Region: PRK09604
278137011748	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
278137011749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137011750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
278137011751	Coenzyme A binding pocket [chemical binding]; other site
278137011752	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
278137011753	Glycoprotease family; Region: Peptidase_M22; pfam00814
278137011754	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
278137011755	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137011756	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137011757	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137011758	alanine racemase; Reviewed; Region: alr; PRK00053
278137011759	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
278137011760	active site
278137011761	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
278137011762	dimer interface [polypeptide binding]; other site
278137011763	substrate binding site [chemical binding]; other site
278137011764	catalytic residues [active]
278137011765	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
278137011766	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
278137011767	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137011768	catalytic residue [active]
278137011769	Uncharacterized conserved protein [Function unknown]; Region: COG0062
278137011770	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
278137011771	putative substrate binding site [chemical binding]; other site
278137011772	putative ATP binding site [chemical binding]; other site
278137011773	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137011774	anti sigma factor interaction site; other site
278137011775	regulatory phosphorylation site [posttranslational modification]; other site
278137011776	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
278137011777	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
278137011778	glutaminase active site [active]
278137011779	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
278137011780	dimer interface [polypeptide binding]; other site
278137011781	active site
278137011782	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
278137011783	dimer interface [polypeptide binding]; other site
278137011784	active site
278137011785	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
278137011786	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137011787	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137011788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011789	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137011790	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137011791	active site
278137011792	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
278137011793	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
278137011794	active site
278137011795	substrate binding site [chemical binding]; other site
278137011796	metal binding site [ion binding]; metal-binding site
278137011797	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
278137011798	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
278137011799	23S rRNA interface [nucleotide binding]; other site
278137011800	L3 interface [polypeptide binding]; other site
278137011801	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
278137011802	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
278137011803	NAD binding site [chemical binding]; other site
278137011804	substrate binding site [chemical binding]; other site
278137011805	catalytic Zn binding site [ion binding]; other site
278137011806	tetramer interface [polypeptide binding]; other site
278137011807	structural Zn binding site [ion binding]; other site
278137011808	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
278137011809	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
278137011810	NAD(P) binding site [chemical binding]; other site
278137011811	catalytic residues [active]
278137011812	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137011813	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011814	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
278137011815	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
278137011816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
278137011817	Proteins of 100 residues with WXG; Region: WXG100; cl02005
278137011818	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
278137011819	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
278137011820	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137011821	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
278137011822	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137011823	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
278137011824	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
278137011825	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
278137011826	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
278137011827	active site
278137011828	catalytic residues [active]
278137011829	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
278137011830	CGNR zinc finger; Region: zf-CGNR; pfam11706
278137011831	EamA-like transporter family; Region: EamA; pfam00892
278137011832	EamA-like transporter family; Region: EamA; pfam00892
278137011833	Cutinase; Region: Cutinase; pfam01083
278137011834	Cutinase; Region: Cutinase; pfam01083
278137011835	Cutinase; Region: Cutinase; pfam01083
278137011836	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
278137011837	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
278137011838	dimerization interface 3.5A [polypeptide binding]; other site
278137011839	active site
278137011840	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
278137011841	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
278137011842	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
278137011843	alphaNTD - beta interaction site [polypeptide binding]; other site
278137011844	alphaNTD homodimer interface [polypeptide binding]; other site
278137011845	alphaNTD - beta' interaction site [polypeptide binding]; other site
278137011846	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
278137011847	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
278137011848	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
278137011849	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
278137011850	RNA binding surface [nucleotide binding]; other site
278137011851	30S ribosomal protein S11; Validated; Region: PRK05309
278137011852	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
278137011853	30S ribosomal protein S13; Region: bact_S13; TIGR03631
278137011854	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
278137011855	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
278137011856	rRNA binding site [nucleotide binding]; other site
278137011857	predicted 30S ribosome binding site; other site
278137011858	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
278137011859	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
278137011860	Sulfate transporter family; Region: Sulfate_transp; pfam00916
278137011861	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
278137011862	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137011863	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137011864	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
278137011865	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011866	Ligand Binding Site [chemical binding]; other site
278137011867	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011868	Ligand Binding Site [chemical binding]; other site
278137011869	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
278137011870	Domain of unknown function DUF21; Region: DUF21; pfam01595
278137011871	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
278137011872	Transporter associated domain; Region: CorC_HlyC; smart01091
278137011873	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
278137011874	ZIP Zinc transporter; Region: Zip; pfam02535
278137011875	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
278137011876	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137011877	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
278137011878	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011879	Ligand Binding Site [chemical binding]; other site
278137011880	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011881	Ligand Binding Site [chemical binding]; other site
278137011882	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
278137011883	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
278137011884	putative substrate binding site [chemical binding]; other site
278137011885	putative ATP binding site [chemical binding]; other site
278137011886	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137011887	active site
278137011888	Erythromycin esterase; Region: Erythro_esteras; pfam05139
278137011889	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
278137011890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137011891	active site
278137011892	motif I; other site
278137011893	motif II; other site
278137011894	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
278137011895	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
278137011896	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
278137011897	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
278137011898	phosphoenolpyruvate synthase; Validated; Region: PRK06464
278137011899	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
278137011900	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
278137011901	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
278137011902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011903	Ligand Binding Site [chemical binding]; other site
278137011904	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011905	Ligand Binding Site [chemical binding]; other site
278137011906	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011907	Ligand Binding Site [chemical binding]; other site
278137011908	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
278137011909	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137011910	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
278137011911	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
278137011912	dimer interface [polypeptide binding]; other site
278137011913	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011914	Ligand Binding Site [chemical binding]; other site
278137011915	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011916	Ligand Binding Site [chemical binding]; other site
278137011917	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
278137011918	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137011919	catalytic Zn binding site [ion binding]; other site
278137011920	structural Zn binding site [ion binding]; other site
278137011921	NAD(P) binding site [chemical binding]; other site
278137011922	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011923	Ligand Binding Site [chemical binding]; other site
278137011924	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011925	Ligand Binding Site [chemical binding]; other site
278137011926	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
278137011927	Ligand Binding Site [chemical binding]; other site
278137011928	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
278137011929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137011930	active site
278137011931	phosphorylation site [posttranslational modification]
278137011932	intermolecular recognition site; other site
278137011933	dimerization interface [polypeptide binding]; other site
278137011934	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
278137011935	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137011936	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
278137011937	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
278137011938	ligand binding site [chemical binding]; other site
278137011939	flexible hinge region; other site
278137011940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137011941	ATP binding site [chemical binding]; other site
278137011942	Mg2+ binding site [ion binding]; other site
278137011943	G-X-G motif; other site
278137011944	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
278137011945	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
278137011946	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
278137011947	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
278137011948	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
278137011949	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
278137011950	NAD binding site [chemical binding]; other site
278137011951	substrate binding site [chemical binding]; other site
278137011952	homodimer interface [polypeptide binding]; other site
278137011953	active site
278137011954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137011955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137011956	hypothetical protein; Provisional; Region: PRK06184
278137011957	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
278137011958	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
278137011959	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
278137011960	tetrameric interface [polypeptide binding]; other site
278137011961	NAD binding site [chemical binding]; other site
278137011962	catalytic residues [active]
278137011963	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137011964	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
278137011965	substrate binding pocket [chemical binding]; other site
278137011966	FAD binding site [chemical binding]; other site
278137011967	catalytic base [active]
278137011968	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
278137011969	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
278137011970	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
278137011971	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137011972	motif II; other site
278137011973	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137011974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137011975	active site
278137011976	phosphorylation site [posttranslational modification]
278137011977	intermolecular recognition site; other site
278137011978	dimerization interface [polypeptide binding]; other site
278137011979	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137011980	DNA binding residues [nucleotide binding]
278137011981	dimerization interface [polypeptide binding]; other site
278137011982	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137011983	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
278137011984	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
278137011985	Histidine kinase; Region: HisKA_3; pfam07730
278137011986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137011987	ATP binding site [chemical binding]; other site
278137011988	Mg2+ binding site [ion binding]; other site
278137011989	G-X-G motif; other site
278137011990	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137011991	Cytochrome P450; Region: p450; cl12078
278137011992	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137011993	MarR family; Region: MarR; pfam01047
278137011994	Putative zinc-finger; Region: zf-HC2; pfam13490
278137011995	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
278137011996	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137011997	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137011998	DNA binding residues [nucleotide binding]
278137011999	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
278137012000	active site
278137012001	adenylate kinase; Reviewed; Region: adk; PRK00279
278137012002	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
278137012003	AMP-binding site [chemical binding]; other site
278137012004	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
278137012005	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
278137012006	SecY translocase; Region: SecY; pfam00344
278137012007	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137012008	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
278137012009	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137012010	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
278137012011	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
278137012012	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
278137012013	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
278137012014	tandem repeat interface [polypeptide binding]; other site
278137012015	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
278137012016	oligomer interface [polypeptide binding]; other site
278137012017	active site residues [active]
278137012018	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
278137012019	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
278137012020	tandem repeat interface [polypeptide binding]; other site
278137012021	oligomer interface [polypeptide binding]; other site
278137012022	active site residues [active]
278137012023	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137012024	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
278137012025	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
278137012026	23S rRNA binding site [nucleotide binding]; other site
278137012027	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
278137012028	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
278137012029	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
278137012030	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
278137012031	5S rRNA interface [nucleotide binding]; other site
278137012032	L27 interface [polypeptide binding]; other site
278137012033	23S rRNA interface [nucleotide binding]; other site
278137012034	L5 interface [polypeptide binding]; other site
278137012035	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
278137012036	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
278137012037	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
278137012038	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
278137012039	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
278137012040	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
278137012041	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
278137012042	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
278137012043	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
278137012044	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
278137012045	RNA binding site [nucleotide binding]; other site
278137012046	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
278137012047	Uncharacterized conserved protein [Function unknown]; Region: COG1262
278137012048	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
278137012049	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
278137012050	Sulfatase; Region: Sulfatase; pfam00884
278137012051	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
278137012052	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
278137012053	putative translocon interaction site; other site
278137012054	23S rRNA interface [nucleotide binding]; other site
278137012055	signal recognition particle (SRP54) interaction site; other site
278137012056	L23 interface [polypeptide binding]; other site
278137012057	trigger factor interaction site; other site
278137012058	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
278137012059	23S rRNA interface [nucleotide binding]; other site
278137012060	5S rRNA interface [nucleotide binding]; other site
278137012061	putative antibiotic binding site [chemical binding]; other site
278137012062	L25 interface [polypeptide binding]; other site
278137012063	L27 interface [polypeptide binding]; other site
278137012064	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
278137012065	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
278137012066	G-X-X-G motif; other site
278137012067	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
278137012068	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
278137012069	putative translocon binding site; other site
278137012070	protein-rRNA interface [nucleotide binding]; other site
278137012071	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
278137012072	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
278137012073	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
278137012074	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
278137012075	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
278137012076	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
278137012077	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
278137012078	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
278137012079	Carboxylesterase family; Region: COesterase; pfam00135
278137012080	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
278137012081	substrate binding pocket [chemical binding]; other site
278137012082	catalytic triad [active]
278137012083	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137012084	Cytochrome P450; Region: p450; cl12078
278137012085	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137012086	Cytochrome P450; Region: p450; cl12078
278137012087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137012088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012089	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
278137012090	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137012091	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
278137012092	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
278137012093	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
278137012094	Probable Catalytic site; other site
278137012095	metal-binding site
278137012096	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
278137012097	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
278137012098	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
278137012099	phosphate binding site [ion binding]; other site
278137012100	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
278137012101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
278137012102	FeS/SAM binding site; other site
278137012103	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
278137012104	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
278137012105	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
278137012106	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012107	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
278137012108	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137012109	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
278137012110	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
278137012111	putative dimer interface [polypeptide binding]; other site
278137012112	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137012113	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
278137012114	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137012115	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
278137012116	active site
278137012117	metal binding site [ion binding]; metal-binding site
278137012118	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137012119	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137012120	active site
278137012121	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
278137012122	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137012123	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
278137012124	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137012125	putative DNA binding site [nucleotide binding]; other site
278137012126	putative Zn2+ binding site [ion binding]; other site
278137012127	AsnC family; Region: AsnC_trans_reg; pfam01037
278137012128	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
278137012129	Amidinotransferase; Region: Amidinotransf; pfam02274
278137012130	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
278137012131	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137012132	inhibitor-cofactor binding pocket; inhibition site
278137012133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137012134	catalytic residue [active]
278137012135	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137012136	classical (c) SDRs; Region: SDR_c; cd05233
278137012137	NAD(P) binding site [chemical binding]; other site
278137012138	active site
278137012139	Short C-terminal domain; Region: SHOCT; pfam09851
278137012140	Cutinase; Region: Cutinase; pfam01083
278137012141	elongation factor Tu; Reviewed; Region: PRK00049
278137012142	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
278137012143	G1 box; other site
278137012144	GEF interaction site [polypeptide binding]; other site
278137012145	GTP/Mg2+ binding site [chemical binding]; other site
278137012146	Switch I region; other site
278137012147	G2 box; other site
278137012148	G3 box; other site
278137012149	Switch II region; other site
278137012150	G4 box; other site
278137012151	G5 box; other site
278137012152	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
278137012153	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
278137012154	Antibiotic Binding Site [chemical binding]; other site
278137012155	elongation factor G; Reviewed; Region: PRK00007
278137012156	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
278137012157	G1 box; other site
278137012158	putative GEF interaction site [polypeptide binding]; other site
278137012159	GTP/Mg2+ binding site [chemical binding]; other site
278137012160	Switch I region; other site
278137012161	G2 box; other site
278137012162	G3 box; other site
278137012163	Switch II region; other site
278137012164	G4 box; other site
278137012165	G5 box; other site
278137012166	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
278137012167	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
278137012168	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
278137012169	30S ribosomal protein S7; Validated; Region: PRK05302
278137012170	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
278137012171	S17 interaction site [polypeptide binding]; other site
278137012172	S8 interaction site; other site
278137012173	16S rRNA interaction site [nucleotide binding]; other site
278137012174	streptomycin interaction site [chemical binding]; other site
278137012175	23S rRNA interaction site [nucleotide binding]; other site
278137012176	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
278137012177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137012178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012179	WHG domain; Region: WHG; pfam13305
278137012180	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
278137012181	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
278137012182	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
278137012183	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
278137012184	Methyltransferase domain; Region: Methyltransf_23; pfam13489
278137012185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
278137012186	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137012187	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137012188	substrate binding site [chemical binding]; other site
278137012189	oxyanion hole (OAH) forming residues; other site
278137012190	trimer interface [polypeptide binding]; other site
278137012191	PaaX-like protein; Region: PaaX; pfam07848
278137012192	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
278137012193	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
278137012194	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012195	active site
278137012196	Methyltransferase domain; Region: Methyltransf_31; pfam13847
278137012197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137012198	S-adenosylmethionine binding site [chemical binding]; other site
278137012199	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
278137012200	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
278137012201	active site
278137012202	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
278137012203	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
278137012204	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
278137012205	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
278137012206	putative active site [active]
278137012207	putative substrate binding site [chemical binding]; other site
278137012208	putative cosubstrate binding site; other site
278137012209	catalytic site [active]
278137012210	endonuclease IV; Provisional; Region: PRK01060
278137012211	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
278137012212	AP (apurinic/apyrimidinic) site pocket; other site
278137012213	DNA interaction; other site
278137012214	Metal-binding active site; metal-binding site
278137012215	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
278137012216	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
278137012217	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
278137012218	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
278137012219	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
278137012220	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
278137012221	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
278137012222	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
278137012223	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
278137012224	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
278137012225	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
278137012226	G-loop; other site
278137012227	DNA binding site [nucleotide binding]
278137012228	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
278137012229	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
278137012230	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
278137012231	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
278137012232	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
278137012233	RPB10 interaction site [polypeptide binding]; other site
278137012234	RPB1 interaction site [polypeptide binding]; other site
278137012235	RPB11 interaction site [polypeptide binding]; other site
278137012236	RPB3 interaction site [polypeptide binding]; other site
278137012237	RPB12 interaction site [polypeptide binding]; other site
278137012238	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
278137012239	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
278137012240	Walker A/P-loop; other site
278137012241	ATP binding site [chemical binding]; other site
278137012242	Q-loop/lid; other site
278137012243	ABC transporter signature motif; other site
278137012244	Walker B; other site
278137012245	D-loop; other site
278137012246	H-loop/switch region; other site
278137012247	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
278137012248	core dimer interface [polypeptide binding]; other site
278137012249	peripheral dimer interface [polypeptide binding]; other site
278137012250	L10 interface [polypeptide binding]; other site
278137012251	L11 interface [polypeptide binding]; other site
278137012252	putative EF-Tu interaction site [polypeptide binding]; other site
278137012253	putative EF-G interaction site [polypeptide binding]; other site
278137012254	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
278137012255	23S rRNA interface [nucleotide binding]; other site
278137012256	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
278137012257	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
278137012258	nucleotide binding site [chemical binding]; other site
278137012259	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
278137012260	active site
278137012261	catalytic site [active]
278137012262	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
278137012263	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
278137012264	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
278137012265	Predicted transcriptional regulator [Transcription]; Region: COG2378
278137012266	HTH domain; Region: HTH_11; pfam08279
278137012267	WYL domain; Region: WYL; pfam13280
278137012268	DinB superfamily; Region: DinB_2; pfam12867
278137012269	Protein of unknown function (DUF664); Region: DUF664; pfam04978
278137012270	DinB superfamily; Region: DinB_2; pfam12867
278137012271	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
278137012272	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
278137012273	ABC1 family; Region: ABC1; cl17513
278137012274	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137012275	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
278137012276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137012277	S-adenosylmethionine binding site [chemical binding]; other site
278137012278	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
278137012279	mRNA/rRNA interface [nucleotide binding]; other site
278137012280	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
278137012281	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
278137012282	23S rRNA interface [nucleotide binding]; other site
278137012283	L7/L12 interface [polypeptide binding]; other site
278137012284	putative thiostrepton binding site; other site
278137012285	L25 interface [polypeptide binding]; other site
278137012286	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
278137012287	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
278137012288	putative homodimer interface [polypeptide binding]; other site
278137012289	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
278137012290	heterodimer interface [polypeptide binding]; other site
278137012291	homodimer interface [polypeptide binding]; other site
278137012292	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
278137012293	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
278137012294	active site
278137012295	catalytic site [active]
278137012296	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
278137012297	active site
278137012298	catalytic site [active]
278137012299	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
278137012300	active site
278137012301	catalytic site [active]
278137012302	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
278137012303	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
278137012304	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
278137012305	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
278137012306	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137012307	substrate binding site [chemical binding]; other site
278137012308	oxyanion hole (OAH) forming residues; other site
278137012309	trimer interface [polypeptide binding]; other site
278137012310	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
278137012311	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
278137012312	oligomer interface [polypeptide binding]; other site
278137012313	metal binding site [ion binding]; metal-binding site
278137012314	metal binding site [ion binding]; metal-binding site
278137012315	putative Cl binding site [ion binding]; other site
278137012316	aspartate ring; other site
278137012317	basic sphincter; other site
278137012318	hydrophobic gate; other site
278137012319	periplasmic entrance; other site
278137012320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
278137012321	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137012322	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
278137012323	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
278137012324	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
278137012325	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
278137012326	Part of AAA domain; Region: AAA_19; pfam13245
278137012327	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
278137012328	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
278137012329	AAA domain; Region: AAA_30; pfam13604
278137012330	Family description; Region: UvrD_C_2; pfam13538
278137012331	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
278137012332	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
278137012333	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
278137012334	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
278137012335	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
278137012336	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
278137012337	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137012338	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137012339	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
278137012340	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
278137012341	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137012342	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
278137012343	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137012344	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
278137012345	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
278137012346	MMPL family; Region: MMPL; pfam03176
278137012347	MMPL family; Region: MMPL; pfam03176
278137012348	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
278137012349	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
278137012350	malonyl-CoA binding site [chemical binding]; other site
278137012351	dimer interface [polypeptide binding]; other site
278137012352	active site
278137012353	product binding site; other site
278137012354	Phospholipid methyltransferase; Region: PEMT; cl17370
278137012355	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
278137012356	MASE1; Region: MASE1; cl17823
278137012357	PAS domain S-box; Region: sensory_box; TIGR00229
278137012358	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
278137012359	putative active site [active]
278137012360	heme pocket [chemical binding]; other site
278137012361	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137012362	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137012363	metal binding site [ion binding]; metal-binding site
278137012364	active site
278137012365	I-site; other site
278137012366	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
278137012367	homodimer interface [polypeptide binding]; other site
278137012368	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
278137012369	active site pocket [active]
278137012370	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
278137012371	Putative esterase; Region: Esterase; pfam00756
278137012372	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
278137012373	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137012374	classical (c) SDRs; Region: SDR_c; cd05233
278137012375	NAD(P) binding site [chemical binding]; other site
278137012376	active site
278137012377	AAA ATPase domain; Region: AAA_16; pfam13191
278137012378	Domain of unknown function DUF87; Region: DUF87; pfam01935
278137012379	AAA-like domain; Region: AAA_10; pfam12846
278137012380	Zonular occludens toxin (Zot); Region: Zot; cl17485
278137012381	Uncharacterized conserved protein [Function unknown]; Region: COG0398
278137012382	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
278137012383	PIF1-like helicase; Region: PIF1; pfam05970
278137012384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137012385	Walker A motif; other site
278137012386	ATP binding site [chemical binding]; other site
278137012387	Walker B motif; other site
278137012388	Family description; Region: UvrD_C_2; pfam13538
278137012389	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
278137012390	catalytic site [active]
278137012391	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
278137012392	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
278137012393	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137012394	catalytic residue [active]
278137012395	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
278137012396	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
278137012397	NAD(P) binding site [chemical binding]; other site
278137012398	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
278137012399	Nitronate monooxygenase; Region: NMO; pfam03060
278137012400	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137012401	FMN binding site [chemical binding]; other site
278137012402	substrate binding site [chemical binding]; other site
278137012403	putative catalytic residue [active]
278137012404	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
278137012405	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
278137012406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
278137012407	P-loop containing region of AAA domain; Region: AAA_29; cl17516
278137012408	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
278137012409	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
278137012410	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
278137012411	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
278137012412	putative [4Fe-4S] binding site [ion binding]; other site
278137012413	putative molybdopterin cofactor binding site [chemical binding]; other site
278137012414	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
278137012415	molybdopterin cofactor binding site; other site
278137012416	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
278137012417	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137012418	Transmembrane secretion effector; Region: MFS_3; pfam05977
278137012419	YceI-like domain; Region: YceI; smart00867
278137012420	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
278137012421	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137012422	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137012423	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012424	active site
278137012425	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012426	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
278137012427	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137012428	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137012429	non-specific DNA binding site [nucleotide binding]; other site
278137012430	salt bridge; other site
278137012431	sequence-specific DNA binding site [nucleotide binding]; other site
278137012432	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
278137012433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137012434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012435	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
278137012436	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012437	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137012438	GAF domain; Region: GAF; pfam01590
278137012439	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137012440	PAS domain S-box; Region: sensory_box; TIGR00229
278137012441	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
278137012442	putative active site [active]
278137012443	heme pocket [chemical binding]; other site
278137012444	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137012445	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137012446	metal binding site [ion binding]; metal-binding site
278137012447	active site
278137012448	I-site; other site
278137012449	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
278137012450	Nuclease-related domain; Region: NERD; pfam08378
278137012451	non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276
278137012452	RNA/DNA hybrid binding site [nucleotide binding]; other site
278137012453	active site
278137012454	PE-PPE domain; Region: PE-PPE; pfam08237
278137012455	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
278137012456	nudix motif; other site
278137012457	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
278137012458	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
278137012459	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
278137012460	active site
278137012461	metal binding site [ion binding]; metal-binding site
278137012462	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137012463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137012464	Transposase; Region: HTH_Tnp_1; pfam01527
278137012465	HTH-like domain; Region: HTH_21; pfam13276
278137012466	Integrase core domain; Region: rve; pfam00665
278137012467	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
278137012468	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137012469	active site
278137012470	DNA binding site [nucleotide binding]
278137012471	Int/Topo IB signature motif; other site
278137012472	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
278137012473	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
278137012474	active site
278137012475	catalytic residues [active]
278137012476	DNA binding site [nucleotide binding]
278137012477	Int/Topo IB signature motif; other site
278137012478	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137012479	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
278137012480	CoA-transferase family III; Region: CoA_transf_3; pfam02515
278137012481	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
278137012482	VanW like protein; Region: VanW; pfam04294
278137012483	ERCC4 domain; Region: ERCC4; smart00891
278137012484	Lsr2; Region: Lsr2; pfam11774
278137012485	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
278137012486	putative active site [active]
278137012487	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
278137012488	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
278137012489	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
278137012490	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
278137012491	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
278137012492	hypothetical protein; Provisional; Region: PRK05463
278137012493	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
278137012494	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
278137012495	putative di-iron ligands [ion binding]; other site
278137012496	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
278137012497	SEC-C motif; Region: SEC-C; pfam02810
278137012498	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
278137012499	putative active site [active]
278137012500	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
278137012501	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
278137012502	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
278137012503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
278137012504	Zeta toxin; Region: Zeta_toxin; pfam06414
278137012505	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
278137012506	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
278137012507	putative active site [active]
278137012508	homotetrameric interface [polypeptide binding]; other site
278137012509	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137012510	AAA domain; Region: AAA_23; pfam13476
278137012511	Walker A/P-loop; other site
278137012512	ATP binding site [chemical binding]; other site
278137012513	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137012514	ATP binding site [chemical binding]; other site
278137012515	putative Mg++ binding site [ion binding]; other site
278137012516	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
278137012517	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137012518	nucleotide binding region [chemical binding]; other site
278137012519	ATP-binding site [chemical binding]; other site
278137012520	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
278137012521	putative catalytic site [active]
278137012522	putative phosphate binding site [ion binding]; other site
278137012523	putative metal binding site [ion binding]; other site
278137012524	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
278137012525	metal ion-dependent adhesion site (MIDAS); other site
278137012526	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137012527	MULE transposase domain; Region: MULE; pfam10551
278137012528	putative transposase OrfB; Reviewed; Region: PHA02517
278137012529	Integrase core domain; Region: rve; pfam00665
278137012530	Integrase core domain; Region: rve_3; cl15866
278137012531	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137012532	putative transposase OrfB; Reviewed; Region: PHA02517
278137012533	HTH-like domain; Region: HTH_21; pfam13276
278137012534	Integrase core domain; Region: rve; pfam00665
278137012535	Integrase core domain; Region: rve_3; pfam13683
278137012536	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137012537	Transposase; Region: HTH_Tnp_1; pfam01527
278137012538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
278137012539	Transposase; Region: HTH_Tnp_1; pfam01527
278137012540	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
278137012541	putative transposase OrfB; Reviewed; Region: PHA02517
278137012542	HTH-like domain; Region: HTH_21; pfam13276
278137012543	Integrase core domain; Region: rve; pfam00665
278137012544	Integrase core domain; Region: rve_3; pfam13683
278137012545	Restriction endonuclease; Region: Mrr_cat; pfam04471
278137012546	Transposase, Mutator family; Region: Transposase_mut; pfam00872
278137012547	MULE transposase domain; Region: MULE; pfam10551
278137012548	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
278137012549	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
278137012550	cofactor binding site; other site
278137012551	DNA binding site [nucleotide binding]
278137012552	substrate interaction site [chemical binding]; other site
278137012553	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
278137012554	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
278137012555	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137012556	ATP binding site [chemical binding]; other site
278137012557	putative Mg++ binding site [ion binding]; other site
278137012558	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137012559	nucleotide binding region [chemical binding]; other site
278137012560	ATP-binding site [chemical binding]; other site
278137012561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137012562	ATP binding site [chemical binding]; other site
278137012563	Domain of unknown function (DUF385); Region: DUF385; pfam04075
278137012564	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
278137012565	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
278137012566	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
278137012567	putative ADP-binding pocket [chemical binding]; other site
278137012568	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137012569	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137012570	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137012571	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137012572	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
278137012573	O-Antigen ligase; Region: Wzy_C; pfam04932
278137012574	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
278137012575	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
278137012576	GAF domain; Region: GAF; pfam01590
278137012577	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137012578	short chain dehydrogenase; Provisional; Region: PRK07791
278137012579	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137012580	NAD(P) binding site [chemical binding]; other site
278137012581	active site
278137012582	short chain dehydrogenase; Provisional; Region: PRK07856
278137012583	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137012584	NAD(P) binding site [chemical binding]; other site
278137012585	active site
278137012586	enoyl-CoA hydratase; Provisional; Region: PRK06495
278137012587	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137012588	substrate binding site [chemical binding]; other site
278137012589	oxyanion hole (OAH) forming residues; other site
278137012590	trimer interface [polypeptide binding]; other site
278137012591	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
278137012592	Coenzyme A transferase; Region: CoA_trans; cl17247
278137012593	Nitronate monooxygenase; Region: NMO; pfam03060
278137012594	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137012595	FMN binding site [chemical binding]; other site
278137012596	substrate binding site [chemical binding]; other site
278137012597	putative catalytic residue [active]
278137012598	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
278137012599	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
278137012600	NAD binding site [chemical binding]; other site
278137012601	catalytic Zn binding site [ion binding]; other site
278137012602	substrate binding site [chemical binding]; other site
278137012603	structural Zn binding site [ion binding]; other site
278137012604	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
278137012605	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
278137012606	nucleophilic elbow; other site
278137012607	catalytic triad; other site
278137012608	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
278137012609	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137012610	dimer interface [polypeptide binding]; other site
278137012611	active site
278137012612	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137012613	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012614	short chain dehydrogenase; Provisional; Region: PRK07831
278137012615	classical (c) SDRs; Region: SDR_c; cd05233
278137012616	NAD(P) binding site [chemical binding]; other site
278137012617	active site
278137012618	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137012619	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
278137012620	FAD binding site [chemical binding]; other site
278137012621	substrate binding site [chemical binding]; other site
278137012622	catalytic base [active]
278137012623	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
278137012624	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137012625	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
278137012626	acyl-activating enzyme (AAE) consensus motif; other site
278137012627	putative AMP binding site [chemical binding]; other site
278137012628	putative active site [active]
278137012629	putative CoA binding site [chemical binding]; other site
278137012630	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137012631	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012632	active site
278137012633	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
278137012634	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012635	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137012636	active site
278137012637	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012638	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137012639	aspartate aminotransferase; Provisional; Region: PRK05764
278137012640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137012641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137012642	homodimer interface [polypeptide binding]; other site
278137012643	catalytic residue [active]
278137012644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137012645	Major Facilitator Superfamily; Region: MFS_1; pfam07690
278137012646	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137012647	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
278137012648	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137012649	acyl-activating enzyme (AAE) consensus motif; other site
278137012650	AMP binding site [chemical binding]; other site
278137012651	active site
278137012652	CoA binding site [chemical binding]; other site
278137012653	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
278137012654	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137012655	NAD(P) binding site [chemical binding]; other site
278137012656	active site
278137012657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137012658	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137012659	putative substrate translocation pore; other site
278137012660	Transcriptional regulator [Transcription]; Region: LysR; COG0583
278137012661	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137012662	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
278137012663	dimerization interface [polypeptide binding]; other site
278137012664	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
278137012665	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137012666	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137012667	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012668	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
278137012669	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
278137012670	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
278137012671	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
278137012672	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
278137012673	active site
278137012674	Fe binding site [ion binding]; other site
278137012675	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
278137012676	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
278137012677	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
278137012678	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137012679	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
278137012680	Flavin binding site [chemical binding]; other site
278137012681	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
278137012682	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
278137012683	FAD binding pocket [chemical binding]; other site
278137012684	FAD binding motif [chemical binding]; other site
278137012685	phosphate binding motif [ion binding]; other site
278137012686	beta-alpha-beta structure motif; other site
278137012687	NAD(p) ribose binding residues [chemical binding]; other site
278137012688	NAD binding pocket [chemical binding]; other site
278137012689	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
278137012690	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137012691	catalytic loop [active]
278137012692	iron binding site [ion binding]; other site
278137012693	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
278137012694	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012695	active site
278137012696	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137012697	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137012698	active site
278137012699	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137012700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137012701	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
278137012702	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
278137012703	Transcriptional regulators [Transcription]; Region: PurR; COG1609
278137012704	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
278137012705	DNA binding site [nucleotide binding]
278137012706	domain linker motif; other site
278137012707	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
278137012708	putative dimerization interface [polypeptide binding]; other site
278137012709	putative ligand binding site [chemical binding]; other site
278137012710	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
278137012711	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
278137012712	ABC-ATPase subunit  interface; other site
278137012713	dimer interface [polypeptide binding]; other site
278137012714	putative PBP binding regions; other site
278137012715	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
278137012716	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
278137012717	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
278137012718	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
278137012719	intersubunit interface [polypeptide binding]; other site
278137012720	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137012721	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137012722	metal binding site [ion binding]; metal-binding site
278137012723	active site
278137012724	I-site; other site
278137012725	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
278137012726	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
278137012727	active site residue [active]
278137012728	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
278137012729	active site residue [active]
278137012730	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
278137012731	putative active site [active]
278137012732	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
278137012733	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
278137012734	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
278137012735	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
278137012736	transmembrane helices; other site
278137012737	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
278137012738	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
278137012739	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
278137012740	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
278137012741	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
278137012742	active site
278137012743	HIGH motif; other site
278137012744	nucleotide binding site [chemical binding]; other site
278137012745	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
278137012746	KMSKS motif; other site
278137012747	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
278137012748	homotrimer interaction site [polypeptide binding]; other site
278137012749	zinc binding site [ion binding]; other site
278137012750	CDP-binding sites; other site
278137012751	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
278137012752	DNA repair protein RadA; Provisional; Region: PRK11823
278137012753	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
278137012754	Walker A motif; other site
278137012755	ATP binding site [chemical binding]; other site
278137012756	Walker B motif; other site
278137012757	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
278137012758	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
278137012759	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
278137012760	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
278137012761	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
278137012762	active site clefts [active]
278137012763	zinc binding site [ion binding]; other site
278137012764	dimer interface [polypeptide binding]; other site
278137012765	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
278137012766	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
278137012767	minor groove reading motif; other site
278137012768	helix-hairpin-helix signature motif; other site
278137012769	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
278137012770	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
278137012771	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
278137012772	conserved cys residue [active]
278137012773	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137012774	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137012775	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137012776	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
278137012777	catalytic site [active]
278137012778	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
278137012779	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
278137012780	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
278137012781	Transposase [DNA replication, recombination, and repair]; Region: COG5421
278137012782	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137012783	catalytic core [active]
278137012784	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
278137012785	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
278137012786	Clp amino terminal domain; Region: Clp_N; pfam02861
278137012787	Clp amino terminal domain; Region: Clp_N; pfam02861
278137012788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137012789	Walker A motif; other site
278137012790	ATP binding site [chemical binding]; other site
278137012791	Walker B motif; other site
278137012792	arginine finger; other site
278137012793	UvrB/uvrC motif; Region: UVR; pfam02151
278137012794	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137012795	Walker A motif; other site
278137012796	ATP binding site [chemical binding]; other site
278137012797	Walker B motif; other site
278137012798	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
278137012799	Lsr2; Region: Lsr2; pfam11774
278137012800	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
278137012801	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
278137012802	dimer interface [polypeptide binding]; other site
278137012803	putative anticodon binding site; other site
278137012804	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
278137012805	motif 1; other site
278137012806	dimer interface [polypeptide binding]; other site
278137012807	active site
278137012808	motif 2; other site
278137012809	motif 3; other site
278137012810	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
278137012811	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
278137012812	active site
278137012813	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
278137012814	dimer interface [polypeptide binding]; other site
278137012815	substrate binding site [chemical binding]; other site
278137012816	catalytic residue [active]
278137012817	pantothenate kinase; Reviewed; Region: PRK13318
278137012818	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
278137012819	tetramerization interface [polypeptide binding]; other site
278137012820	active site
278137012821	Pantoate-beta-alanine ligase; Region: PanC; cd00560
278137012822	pantoate--beta-alanine ligase; Region: panC; TIGR00018
278137012823	active site
278137012824	ATP-binding site [chemical binding]; other site
278137012825	pantoate-binding site; other site
278137012826	HXXH motif; other site
278137012827	Uncharacterized conserved protein [Function unknown]; Region: COG5495
278137012828	Rossmann-like domain; Region: Rossmann-like; pfam10727
278137012829	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
278137012830	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
278137012831	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
278137012832	catalytic center binding site [active]
278137012833	ATP binding site [chemical binding]; other site
278137012834	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
278137012835	homooctamer interface [polypeptide binding]; other site
278137012836	active site
278137012837	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
278137012838	dihydropteroate synthase; Region: DHPS; TIGR01496
278137012839	substrate binding pocket [chemical binding]; other site
278137012840	dimer interface [polypeptide binding]; other site
278137012841	inhibitor binding site; inhibition site
278137012842	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
278137012843	homodecamer interface [polypeptide binding]; other site
278137012844	GTP cyclohydrolase I; Provisional; Region: PLN03044
278137012845	active site
278137012846	putative catalytic site residues [active]
278137012847	zinc binding site [ion binding]; other site
278137012848	GTP-CH-I/GFRP interaction surface; other site
278137012849	FtsH Extracellular; Region: FtsH_ext; pfam06480
278137012850	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
278137012851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137012852	Walker A motif; other site
278137012853	ATP binding site [chemical binding]; other site
278137012854	Walker B motif; other site
278137012855	arginine finger; other site
278137012856	Peptidase family M41; Region: Peptidase_M41; pfam01434
278137012857	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137012858	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
278137012859	Uncharacterized conserved protein [Function unknown]; Region: COG2968
278137012860	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
278137012861	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
278137012862	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
278137012863	molybdopterin cofactor binding site; other site
278137012864	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
278137012865	molybdopterin cofactor binding site; other site
278137012866	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137012867	active site
278137012868	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
278137012869	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
278137012870	Ligand Binding Site [chemical binding]; other site
278137012871	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
278137012872	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
278137012873	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
278137012874	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
278137012875	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
278137012876	dimer interface [polypeptide binding]; other site
278137012877	substrate binding site [chemical binding]; other site
278137012878	metal binding sites [ion binding]; metal-binding site
278137012879	putative OHCU decarboxylase; Provisional; Region: PRK13798
278137012880	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
278137012881	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
278137012882	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
278137012883	acyl-activating enzyme (AAE) consensus motif; other site
278137012884	AMP binding site [chemical binding]; other site
278137012885	active site
278137012886	CoA binding site [chemical binding]; other site
278137012887	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
278137012888	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
278137012889	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
278137012890	putative trimer interface [polypeptide binding]; other site
278137012891	putative CoA binding site [chemical binding]; other site
278137012892	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
278137012893	putative trimer interface [polypeptide binding]; other site
278137012894	putative CoA binding site [chemical binding]; other site
278137012895	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
278137012896	Zn binding site [ion binding]; other site
278137012897	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
278137012898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137012899	NAD(P) binding site [chemical binding]; other site
278137012900	active site
278137012901	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
278137012902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137012903	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
278137012904	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137012905	DNA polymerase III subunit delta'; Validated; Region: PRK07940
278137012906	DNA polymerase III subunit delta'; Validated; Region: PRK08485
278137012907	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
278137012908	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
278137012909	dimerization interface [polypeptide binding]; other site
278137012910	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
278137012911	cyclase homology domain; Region: CHD; cd07302
278137012912	nucleotidyl binding site; other site
278137012913	metal binding site [ion binding]; metal-binding site
278137012914	dimer interface [polypeptide binding]; other site
278137012915	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
278137012916	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
278137012917	active site
278137012918	interdomain interaction site; other site
278137012919	putative metal-binding site [ion binding]; other site
278137012920	nucleotide binding site [chemical binding]; other site
278137012921	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
278137012922	domain I; other site
278137012923	phosphate binding site [ion binding]; other site
278137012924	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
278137012925	domain II; other site
278137012926	domain III; other site
278137012927	nucleotide binding site [chemical binding]; other site
278137012928	DNA binding groove [nucleotide binding]
278137012929	catalytic site [active]
278137012930	domain IV; other site
278137012931	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
278137012932	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
278137012933	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
278137012934	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
278137012935	DNA-binding site [nucleotide binding]; DNA binding site
278137012936	RNA-binding motif; other site
278137012937	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
278137012938	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137012939	ATP binding site [chemical binding]; other site
278137012940	putative Mg++ binding site [ion binding]; other site
278137012941	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
278137012942	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137012943	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137012944	active site
278137012945	ATP binding site [chemical binding]; other site
278137012946	substrate binding site [chemical binding]; other site
278137012947	activation loop (A-loop); other site
278137012948	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
278137012949	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
278137012950	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
278137012951	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
278137012952	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
278137012953	ATP binding site [chemical binding]; other site
278137012954	Walker A motif; other site
278137012955	hexamer interface [polypeptide binding]; other site
278137012956	Walker B motif; other site
278137012957	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
278137012958	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
278137012959	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137012960	motif II; other site
278137012961	acetyl-CoA synthetase; Provisional; Region: PRK00174
278137012962	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
278137012963	active site
278137012964	CoA binding site [chemical binding]; other site
278137012965	acyl-activating enzyme (AAE) consensus motif; other site
278137012966	AMP binding site [chemical binding]; other site
278137012967	acetate binding site [chemical binding]; other site
278137012968	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
278137012969	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137012970	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
278137012971	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
278137012972	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
278137012973	putative active site [active]
278137012974	putative CoA binding site [chemical binding]; other site
278137012975	nudix motif; other site
278137012976	metal binding site [ion binding]; metal-binding site
278137012977	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
278137012978	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
278137012979	catalytic residues [active]
278137012980	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
278137012981	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
278137012982	minor groove reading motif; other site
278137012983	helix-hairpin-helix signature motif; other site
278137012984	substrate binding pocket [chemical binding]; other site
278137012985	active site
278137012986	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
278137012987	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
278137012988	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
278137012989	ligand binding site [chemical binding]; other site
278137012990	flexible hinge region; other site
278137012991	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
278137012992	putative switch regulator; other site
278137012993	non-specific DNA interactions [nucleotide binding]; other site
278137012994	DNA binding site [nucleotide binding]
278137012995	sequence specific DNA binding site [nucleotide binding]; other site
278137012996	putative cAMP binding site [chemical binding]; other site
278137012997	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
278137012998	AAA domain; Region: AAA_22; pfam13401
278137012999	ATP-binding site [chemical binding]; other site
278137013000	Helix-turn-helix domain; Region: HTH_28; pfam13518
278137013001	Winged helix-turn helix; Region: HTH_29; pfam13551
278137013002	Homeodomain-like domain; Region: HTH_32; pfam13565
278137013003	Integrase core domain; Region: rve; pfam00665
278137013004	Integrase core domain; Region: rve_3; pfam13683
278137013005	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
278137013006	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137013007	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137013008	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
278137013009	homotrimer interaction site [polypeptide binding]; other site
278137013010	putative active site [active]
278137013011	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
278137013012	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
278137013013	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
278137013014	P loop; other site
278137013015	Nucleotide binding site [chemical binding]; other site
278137013016	DTAP/Switch II; other site
278137013017	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
278137013018	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
278137013019	DTAP/Switch II; other site
278137013020	Switch I; other site
278137013021	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
278137013022	Transcription factor WhiB; Region: Whib; pfam02467
278137013023	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
278137013024	Transglycosylase; Region: Transgly; pfam00912
278137013025	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
278137013026	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
278137013027	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
278137013028	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
278137013029	putative active site [active]
278137013030	putative metal binding site [ion binding]; other site
278137013031	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
278137013032	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
278137013033	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137013034	catalytic residue [active]
278137013035	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
278137013036	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
278137013037	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
278137013038	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
278137013039	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
278137013040	active site
278137013041	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
278137013042	Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
278137013043	active site
278137013044	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
278137013045	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137013046	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
278137013047	dimerization interface [polypeptide binding]; other site
278137013048	substrate binding pocket [chemical binding]; other site
278137013049	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
278137013050	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137013051	iron-sulfur cluster [ion binding]; other site
278137013052	[2Fe-2S] cluster binding site [ion binding]; other site
278137013053	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
278137013054	putative alpha subunit interface [polypeptide binding]; other site
278137013055	putative active site [active]
278137013056	putative substrate binding site [chemical binding]; other site
278137013057	Fe binding site [ion binding]; other site
278137013058	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
278137013059	inter-subunit interface; other site
278137013060	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
278137013061	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
278137013062	catalytic loop [active]
278137013063	iron binding site [ion binding]; other site
278137013064	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
278137013065	FAD binding pocket [chemical binding]; other site
278137013066	FAD binding motif [chemical binding]; other site
278137013067	phosphate binding motif [ion binding]; other site
278137013068	beta-alpha-beta structure motif; other site
278137013069	NAD binding pocket [chemical binding]; other site
278137013070	Transcriptional regulators [Transcription]; Region: GntR; COG1802
278137013071	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
278137013072	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
278137013073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137013074	NAD(P) binding site [chemical binding]; other site
278137013075	active site
278137013076	AAA ATPase domain; Region: AAA_16; pfam13191
278137013077	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137013078	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137013079	DNA binding residues [nucleotide binding]
278137013080	dimerization interface [polypeptide binding]; other site
278137013081	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
278137013082	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
278137013083	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
278137013084	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
278137013085	TAP-like protein; Region: Abhydrolase_4; pfam08386
278137013086	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
278137013087	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
278137013088	dimer interface [polypeptide binding]; other site
278137013089	active site
278137013090	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
278137013091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137013092	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
278137013093	dimerization interface [polypeptide binding]; other site
278137013094	substrate binding pocket [chemical binding]; other site
278137013095	Methyltransferase domain; Region: Methyltransf_26; pfam13659
278137013096	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
278137013097	active site
278137013098	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137013099	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
278137013100	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
278137013101	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
278137013102	MoxR-like ATPases [General function prediction only]; Region: COG0714
278137013103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137013104	Walker A motif; other site
278137013105	ATP binding site [chemical binding]; other site
278137013106	Walker B motif; other site
278137013107	arginine finger; other site
278137013108	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
278137013109	Protein of unknown function DUF58; Region: DUF58; pfam01882
278137013110	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
278137013111	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
278137013112	Predicted membrane protein/domain [Function unknown]; Region: COG1714
278137013113	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
278137013114	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
278137013115	Predicted transcriptional regulators [Transcription]; Region: COG1695
278137013116	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
278137013117	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
278137013118	Predicted transcriptional regulators [Transcription]; Region: COG1695
278137013119	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
278137013120	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
278137013121	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
278137013122	active site
278137013123	catalytic tetrad [active]
278137013124	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
278137013125	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
278137013126	G1 box; other site
278137013127	putative GEF interaction site [polypeptide binding]; other site
278137013128	GTP/Mg2+ binding site [chemical binding]; other site
278137013129	Switch I region; other site
278137013130	G2 box; other site
278137013131	G3 box; other site
278137013132	Switch II region; other site
278137013133	G4 box; other site
278137013134	G5 box; other site
278137013135	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
278137013136	glycerol kinase; Provisional; Region: glpK; PRK00047
278137013137	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137013138	nucleotide binding site [chemical binding]; other site
278137013139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137013140	S-adenosylmethionine binding site [chemical binding]; other site
278137013141	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137013142	S-adenosylmethionine binding site [chemical binding]; other site
278137013143	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
278137013144	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
278137013145	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137013146	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137013147	Cytochrome P450; Region: p450; cl12078
278137013148	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137013149	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
278137013150	ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343
278137013151	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
278137013152	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137013153	catalytic residue [active]
278137013154	Uncharacterized conserved protein [Function unknown]; Region: COG4301
278137013155	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
278137013156	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
278137013157	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
278137013158	putative active site [active]
278137013159	putative dimer interface [polypeptide binding]; other site
278137013160	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
278137013161	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
278137013162	ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444
278137013163	PknH-like extracellular domain; Region: PknH_C; pfam14032
278137013164	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
278137013165	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
278137013166	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
278137013167	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
278137013168	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
278137013169	30S ribosomal protein S18; Provisional; Region: PRK13401
278137013170	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
278137013171	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
278137013172	tetramer interface [polypeptide binding]; other site
278137013173	heme binding pocket [chemical binding]; other site
278137013174	NADPH binding site [chemical binding]; other site
278137013175	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
278137013176	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
278137013177	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
278137013178	aspartate kinase; Reviewed; Region: PRK06635
278137013179	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
278137013180	putative nucleotide binding site [chemical binding]; other site
278137013181	putative catalytic residues [active]
278137013182	putative Mg ion binding site [ion binding]; other site
278137013183	putative aspartate binding site [chemical binding]; other site
278137013184	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
278137013185	putative allosteric regulatory site; other site
278137013186	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
278137013187	putative allosteric regulatory residue; other site
278137013188	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
278137013189	putative FMN binding site [chemical binding]; other site
278137013190	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
278137013191	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
278137013192	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
278137013193	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
278137013194	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
278137013195	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
278137013196	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
278137013197	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
278137013198	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
278137013199	active site
278137013200	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
278137013201	domain_subunit interface; other site
278137013202	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
278137013203	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
278137013204	active site
278137013205	FMN binding site [chemical binding]; other site
278137013206	substrate binding site [chemical binding]; other site
278137013207	3Fe-4S cluster binding site [ion binding]; other site
278137013208	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
278137013209	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137013210	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137013211	non-specific DNA binding site [nucleotide binding]; other site
278137013212	salt bridge; other site
278137013213	sequence-specific DNA binding site [nucleotide binding]; other site
278137013214	Cupin domain; Region: Cupin_2; pfam07883
278137013215	2-isopropylmalate synthase; Validated; Region: PRK03739
278137013216	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
278137013217	active site
278137013218	catalytic residues [active]
278137013219	metal binding site [ion binding]; metal-binding site
278137013220	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
278137013221	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
278137013222	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
278137013223	active site
278137013224	catalytic site [active]
278137013225	substrate binding site [chemical binding]; other site
278137013226	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
278137013227	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
278137013228	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
278137013229	catalytic triad [active]
278137013230	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
278137013231	Integrase core domain; Region: rve; pfam00665
278137013232	Integrase core domain; Region: rve_3; pfam13683
278137013233	recombination protein RecR; Reviewed; Region: recR; PRK00076
278137013234	RecR protein; Region: RecR; pfam02132
278137013235	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
278137013236	putative active site [active]
278137013237	putative metal-binding site [ion binding]; other site
278137013238	tetramer interface [polypeptide binding]; other site
278137013239	hypothetical protein; Validated; Region: PRK00153
278137013240	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
278137013241	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
278137013242	active site
278137013243	metal binding site [ion binding]; metal-binding site
278137013244	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
278137013245	hydrophobic ligand binding site; other site
278137013246	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
278137013247	FAD binding domain; Region: FAD_binding_4; pfam01565
278137013248	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
278137013249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137013250	S-adenosylmethionine binding site [chemical binding]; other site
278137013251	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
278137013252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
278137013253	Walker A motif; other site
278137013254	ATP binding site [chemical binding]; other site
278137013255	Walker B motif; other site
278137013256	arginine finger; other site
278137013257	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
278137013258	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
278137013259	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
278137013260	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137013261	catalytic residue [active]
278137013262	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
278137013263	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
278137013264	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137013265	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
278137013266	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
278137013267	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
278137013268	nucleophilic elbow; other site
278137013269	catalytic triad; other site
278137013270	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
278137013271	nucleotide binding site [chemical binding]; other site
278137013272	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
278137013273	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
278137013274	active site
278137013275	DNA binding site [nucleotide binding]
278137013276	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
278137013277	DNA binding site [nucleotide binding]
278137013278	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137013279	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137013280	active site
278137013281	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137013282	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137013283	SnoaL-like domain; Region: SnoaL_4; pfam13577
278137013284	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
278137013285	classical (c) SDRs; Region: SDR_c; cd05233
278137013286	NAD(P) binding site [chemical binding]; other site
278137013287	active site
278137013288	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137013289	Cytochrome P450; Region: p450; cl12078
278137013290	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137013291	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137013292	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137013293	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
278137013294	active site
278137013295	metal binding site [ion binding]; metal-binding site
278137013296	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
278137013297	classical (c) SDRs; Region: SDR_c; cd05233
278137013298	NAD(P) binding site [chemical binding]; other site
278137013299	active site
278137013300	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
278137013301	FMN binding site [chemical binding]; other site
278137013302	dimer interface [polypeptide binding]; other site
278137013303	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
278137013304	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137013305	short chain dehydrogenase; Provisional; Region: PRK08303
278137013306	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137013307	NAD(P) binding site [chemical binding]; other site
278137013308	active site
278137013309	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137013310	Cytochrome P450; Region: p450; cl12078
278137013311	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
278137013312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137013313	NAD(P) binding site [chemical binding]; other site
278137013314	active site
278137013315	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137013316	Cytochrome P450; Region: p450; cl12078
278137013317	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
278137013318	classical (c) SDRs; Region: SDR_c; cd05233
278137013319	NAD(P) binding site [chemical binding]; other site
278137013320	active site
278137013321	choline dehydrogenase; Validated; Region: PRK02106
278137013322	lycopene cyclase; Region: lycopene_cycl; TIGR01789
278137013323	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
278137013324	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
278137013325	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
278137013326	active site
278137013327	DNA binding site [nucleotide binding]
278137013328	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
278137013329	DNA binding site [nucleotide binding]
278137013330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137013331	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
278137013332	Subunit I/III interface [polypeptide binding]; other site
278137013333	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
278137013334	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137013335	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
278137013336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
278137013337	propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443
278137013338	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
278137013339	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
278137013340	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
278137013341	alpha-beta subunit interface [polypeptide binding]; other site
278137013342	alpha-gamma subunit interface [polypeptide binding]; other site
278137013343	active site
278137013344	substrate and K+ binding site; other site
278137013345	K+ binding site [ion binding]; other site
278137013346	cobalamin binding site [chemical binding]; other site
278137013347	Dehydratase medium subunit; Region: Dehydratase_MU; cl17703
278137013348	Amino acid permease; Region: AA_permease; pfam00324
278137013349	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
278137013350	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137013351	inhibitor-cofactor binding pocket; inhibition site
278137013352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137013353	catalytic residue [active]
278137013354	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
278137013355	putative catalytic cysteine [active]
278137013356	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
278137013357	putative hexamer interface [polypeptide binding]; other site
278137013358	putative hexagonal pore; other site
278137013359	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
278137013360	putative hexamer interface [polypeptide binding]; other site
278137013361	putative hexagonal pore; other site
278137013362	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
278137013363	Hexamer/Pentamer interface [polypeptide binding]; other site
278137013364	central pore; other site
278137013365	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
278137013366	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
278137013367	Hexamer interface [polypeptide binding]; other site
278137013368	Hexagonal pore residue; other site
278137013369	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
278137013370	Hexamer interface [polypeptide binding]; other site
278137013371	Hexagonal pore residue; other site
278137013372	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
278137013373	Hexamer interface [polypeptide binding]; other site
278137013374	Hexagonal pore residue; other site
278137013375	Phosphotransferase enzyme family; Region: APH; pfam01636
278137013376	short chain dehydrogenase; Provisional; Region: PRK12829
278137013377	classical (c) SDRs; Region: SDR_c; cd05233
278137013378	NAD(P) binding site [chemical binding]; other site
278137013379	active site
278137013380	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137013381	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
278137013382	DNA-binding site [nucleotide binding]; DNA binding site
278137013383	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
278137013384	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
278137013385	active site
278137013386	HIGH motif; other site
278137013387	nucleotide binding site [chemical binding]; other site
278137013388	active site
278137013389	KMSKS motif; other site
278137013390	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137013391	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137013392	substrate binding pocket [chemical binding]; other site
278137013393	membrane-bound complex binding site; other site
278137013394	hinge residues; other site
278137013395	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
278137013396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137013397	dimer interface [polypeptide binding]; other site
278137013398	conserved gate region; other site
278137013399	putative PBP binding loops; other site
278137013400	ABC-ATPase subunit interface; other site
278137013401	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
278137013402	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
278137013403	Walker A/P-loop; other site
278137013404	ATP binding site [chemical binding]; other site
278137013405	Q-loop/lid; other site
278137013406	ABC transporter signature motif; other site
278137013407	Walker B; other site
278137013408	D-loop; other site
278137013409	H-loop/switch region; other site
278137013410	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
278137013411	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137013412	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137013413	Cytochrome P450; Region: p450; cl12078
278137013414	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
278137013415	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
278137013416	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
278137013417	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
278137013418	Protein of unknown function (DUF732); Region: DUF732; pfam05305
278137013419	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
278137013420	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
278137013421	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
278137013422	FMN binding site [chemical binding]; other site
278137013423	substrate binding site [chemical binding]; other site
278137013424	putative catalytic residue [active]
278137013425	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
278137013426	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
278137013427	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
278137013428	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
278137013429	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
278137013430	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
278137013431	active site
278137013432	P-loop; other site
278137013433	phosphorylation site [posttranslational modification]
278137013434	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
278137013435	active site
278137013436	phosphorylation site [posttranslational modification]
278137013437	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137013438	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
278137013439	putative NAD(P) binding site [chemical binding]; other site
278137013440	catalytic Zn binding site [ion binding]; other site
278137013441	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
278137013442	nucleoside/Zn binding site; other site
278137013443	dimer interface [polypeptide binding]; other site
278137013444	catalytic motif [active]
278137013445	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
278137013446	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
278137013447	prephenate dehydrogenase; Validated; Region: PRK08507
278137013448	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
278137013449	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137013450	putative PBP binding loops; other site
278137013451	dimer interface [polypeptide binding]; other site
278137013452	ABC-ATPase subunit interface; other site
278137013453	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
278137013454	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
278137013455	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
278137013456	Walker A/P-loop; other site
278137013457	ATP binding site [chemical binding]; other site
278137013458	Q-loop/lid; other site
278137013459	ABC transporter signature motif; other site
278137013460	Walker B; other site
278137013461	D-loop; other site
278137013462	H-loop/switch region; other site
278137013463	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
278137013464	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
278137013465	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
278137013466	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
278137013467	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
278137013468	putative active site [active]
278137013469	putative substrate binding site [chemical binding]; other site
278137013470	ATP binding site [chemical binding]; other site
278137013471	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137013472	catalytic core [active]
278137013473	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
278137013474	classical (c) SDRs; Region: SDR_c; cd05233
278137013475	NAD(P) binding site [chemical binding]; other site
278137013476	active site
278137013477	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
278137013478	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
278137013479	Cupin domain; Region: Cupin_2; cl17218
278137013480	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
278137013481	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
278137013482	active site
278137013483	metal binding site [ion binding]; metal-binding site
278137013484	homotetramer interface [polypeptide binding]; other site
278137013485	Transposase; Region: DEDD_Tnp_IS110; pfam01548
278137013486	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
278137013487	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
278137013488	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
278137013489	D-pathway; other site
278137013490	Putative ubiquinol binding site [chemical binding]; other site
278137013491	Low-spin heme (heme b) binding site [chemical binding]; other site
278137013492	Putative water exit pathway; other site
278137013493	Binuclear center (heme o3/CuB) [ion binding]; other site
278137013494	K-pathway; other site
278137013495	Putative proton exit pathway; other site
278137013496	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
278137013497	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137013498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137013499	homodimer interface [polypeptide binding]; other site
278137013500	catalytic residue [active]
278137013501	enoyl-CoA hydratase; Provisional; Region: PRK06142
278137013502	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
278137013503	substrate binding site [chemical binding]; other site
278137013504	oxyanion hole (OAH) forming residues; other site
278137013505	trimer interface [polypeptide binding]; other site
278137013506	DoxX-like family; Region: DoxX_2; pfam13564
278137013507	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137013508	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
278137013509	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
278137013510	DNA binding residues [nucleotide binding]
278137013511	Transcriptional regulators [Transcription]; Region: MarR; COG1846
278137013512	MarR family; Region: MarR; pfam01047
278137013513	MarR family; Region: MarR_2; cl17246
278137013514	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
278137013515	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
278137013516	NAD(P) binding site [chemical binding]; other site
278137013517	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
278137013518	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
278137013519	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
278137013520	catalytic residue [active]
278137013521	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
278137013522	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
278137013523	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
278137013524	Walker A/P-loop; other site
278137013525	ATP binding site [chemical binding]; other site
278137013526	Q-loop/lid; other site
278137013527	ABC transporter signature motif; other site
278137013528	Walker B; other site
278137013529	D-loop; other site
278137013530	H-loop/switch region; other site
278137013531	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
278137013532	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
278137013533	active site
278137013534	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
278137013535	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
278137013536	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
278137013537	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
278137013538	Helix-turn-helix domain; Region: HTH_38; pfam13936
278137013539	Integrase core domain; Region: rve; pfam00665
278137013540	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
278137013541	Uncharacterized conserved protein [Function unknown]; Region: COG2128
278137013542	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
278137013543	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137013544	DNA-binding site [nucleotide binding]; DNA binding site
278137013545	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
278137013546	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137013547	homodimer interface [polypeptide binding]; other site
278137013548	catalytic residue [active]
278137013549	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137013550	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137013551	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137013552	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137013553	active site
278137013554	Predicted membrane protein [Function unknown]; Region: COG2246
278137013555	GtrA-like protein; Region: GtrA; pfam04138
278137013556	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
278137013557	FAD binding domain; Region: FAD_binding_4; pfam01565
278137013558	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
278137013559	short chain dehydrogenase; Provisional; Region: PRK07904
278137013560	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
278137013561	active site
278137013562	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
278137013563	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
278137013564	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
278137013565	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
278137013566	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
278137013567	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
278137013568	Catalytic domain of Protein Kinases; Region: PKc; cd00180
278137013569	active site
278137013570	ATP binding site [chemical binding]; other site
278137013571	substrate binding site [chemical binding]; other site
278137013572	activation loop (A-loop); other site
278137013573	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
278137013574	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
278137013575	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
278137013576	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
278137013577	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137013578	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
278137013579	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
278137013580	active site
278137013581	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
278137013582	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
278137013583	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
278137013584	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
278137013585	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
278137013586	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
278137013587	acyl-activating enzyme (AAE) consensus motif; other site
278137013588	active site
278137013589	Cutinase; Region: Cutinase; pfam01083
278137013590	Putative esterase; Region: Esterase; pfam00756
278137013591	Predicted esterase [General function prediction only]; Region: COG0627
278137013592	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
278137013593	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
278137013594	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
278137013595	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
278137013596	active site
278137013597	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
278137013598	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137013599	UDP-galactopyranose mutase; Region: GLF; pfam03275
278137013600	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
278137013601	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
278137013602	amidase catalytic site [active]
278137013603	Zn binding residues [ion binding]; other site
278137013604	substrate binding site [chemical binding]; other site
278137013605	LGFP repeat; Region: LGFP; pfam08310
278137013606	AAA ATPase domain; Region: AAA_16; pfam13191
278137013607	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
278137013608	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
278137013609	DNA binding residues [nucleotide binding]
278137013610	dimerization interface [polypeptide binding]; other site
278137013611	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
278137013612	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137013613	active site
278137013614	motif I; other site
278137013615	motif II; other site
278137013616	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
278137013617	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
278137013618	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137013619	putative acyl-acceptor binding pocket; other site
278137013620	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137013621	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
278137013622	putative acyl-acceptor binding pocket; other site
278137013623	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
278137013624	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
278137013625	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
278137013626	iron-sulfur cluster [ion binding]; other site
278137013627	[2Fe-2S] cluster binding site [ion binding]; other site
278137013628	seryl-tRNA synthetase; Provisional; Region: PRK05431
278137013629	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
278137013630	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
278137013631	dimer interface [polypeptide binding]; other site
278137013632	active site
278137013633	motif 1; other site
278137013634	motif 2; other site
278137013635	motif 3; other site
278137013636	Septum formation; Region: Septum_form; pfam13845
278137013637	Septum formation; Region: Septum_form; pfam13845
278137013638	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
278137013639	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
278137013640	catalytic core [active]
278137013641	prephenate dehydratase; Provisional; Region: PRK11898
278137013642	Prephenate dehydratase; Region: PDT; pfam00800
278137013643	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
278137013644	putative L-Phe binding site [chemical binding]; other site
278137013645	CAAX protease self-immunity; Region: Abi; pfam02517
278137013646	Transcriptional regulator [Transcription]; Region: LytR; COG1316
278137013647	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
278137013648	Ferritin-like domain; Region: Ferritin; pfam00210
278137013649	ferroxidase diiron center [ion binding]; other site
278137013650	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
278137013651	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
278137013652	putative active site [active]
278137013653	catalytic site [active]
278137013654	putative metal binding site [ion binding]; other site
278137013655	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
278137013656	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
278137013657	active site residue [active]
278137013658	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
278137013659	Catalytic site [active]
278137013660	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
278137013661	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137013662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
278137013663	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
278137013664	CopC domain; Region: CopC; pfam04234
278137013665	Copper resistance protein D; Region: CopD; pfam05425
278137013666	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
278137013667	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137013668	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137013669	DNA polymerase IV; Validated; Region: PRK03858
278137013670	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
278137013671	active site
278137013672	DNA binding site [nucleotide binding]
278137013673	hypothetical protein; Provisional; Region: PRK07945
278137013674	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
278137013675	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
278137013676	active site
278137013677	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
278137013678	dimerization interface [polypeptide binding]; other site
278137013679	putative DNA binding site [nucleotide binding]; other site
278137013680	putative Zn2+ binding site [ion binding]; other site
278137013681	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
278137013682	Sulfate transporter family; Region: Sulfate_transp; pfam00916
278137013683	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
278137013684	TIGR03086 family protein; Region: TIGR03086
278137013685	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
278137013686	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
278137013687	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
278137013688	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
278137013689	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
278137013690	active site
278137013691	dimer interface [polypeptide binding]; other site
278137013692	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
278137013693	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
278137013694	active site
278137013695	FMN binding site [chemical binding]; other site
278137013696	substrate binding site [chemical binding]; other site
278137013697	3Fe-4S cluster binding site [ion binding]; other site
278137013698	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
278137013699	domain interface; other site
278137013700	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
278137013701	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
278137013702	dimerization interface [polypeptide binding]; other site
278137013703	DPS ferroxidase diiron center [ion binding]; other site
278137013704	ion pore; other site
278137013705	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
278137013706	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
278137013707	minor groove reading motif; other site
278137013708	helix-hairpin-helix signature motif; other site
278137013709	active site
278137013710	Domain of unknown function (DUF427); Region: DUF427; pfam04248
278137013711	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
278137013712	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
278137013713	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
278137013714	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
278137013715	putative NADP binding site [chemical binding]; other site
278137013716	putative substrate binding site [chemical binding]; other site
278137013717	active site
278137013718	SnoaL-like domain; Region: SnoaL_2; pfam12680
278137013719	SelR domain; Region: SelR; pfam01641
278137013720	methionine sulfoxide reductase B; Provisional; Region: PRK00222
278137013721	methionine sulfoxide reductase A; Provisional; Region: PRK14054
278137013722	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
278137013723	Cytochrome P450; Region: p450; cl12078
278137013724	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137013725	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137013726	Methyltransferase domain; Region: Methyltransf_24; pfam13578
278137013727	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
278137013728	Protein of unknown function, DUF608; Region: DUF608; pfam04685
278137013729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137013730	S-adenosylmethionine binding site [chemical binding]; other site
278137013731	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
278137013732	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
278137013733	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
278137013734	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137013735	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
278137013736	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
278137013737	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
278137013738	active site
278137013739	PAS fold; Region: PAS_3; pfam08447
278137013740	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
278137013741	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
278137013742	Isochorismatase family; Region: Isochorismatase; pfam00857
278137013743	catalytic triad [active]
278137013744	metal binding site [ion binding]; metal-binding site
278137013745	conserved cis-peptide bond; other site
278137013746	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
278137013747	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
278137013748	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
278137013749	active site
278137013750	catalytic site [active]
278137013751	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
278137013752	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
278137013753	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
278137013754	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
278137013755	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
278137013756	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
278137013757	active site
278137013758	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
278137013759	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137013760	Walker A/P-loop; other site
278137013761	ATP binding site [chemical binding]; other site
278137013762	Q-loop/lid; other site
278137013763	ABC transporter signature motif; other site
278137013764	Walker B; other site
278137013765	D-loop; other site
278137013766	H-loop/switch region; other site
278137013767	TOBE domain; Region: TOBE_2; pfam08402
278137013768	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137013769	dimer interface [polypeptide binding]; other site
278137013770	conserved gate region; other site
278137013771	putative PBP binding loops; other site
278137013772	ABC-ATPase subunit interface; other site
278137013773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
278137013774	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
278137013775	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
278137013776	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
278137013777	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
278137013778	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137013779	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137013780	DNA binding residues [nucleotide binding]
278137013781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137013782	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137013783	putative substrate translocation pore; other site
278137013784	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
278137013785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137013786	motif II; other site
278137013787	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
278137013788	Rhomboid family; Region: Rhomboid; pfam01694
278137013789	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
278137013790	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
278137013791	active site
278137013792	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
278137013793	Beta-lactamase; Region: Beta-lactamase; pfam00144
278137013794	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
278137013795	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
278137013796	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
278137013797	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
278137013798	putative NAD(P) binding site [chemical binding]; other site
278137013799	catalytic Zn binding site [ion binding]; other site
278137013800	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
278137013801	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137013802	ATP binding site [chemical binding]; other site
278137013803	putative Mg++ binding site [ion binding]; other site
278137013804	nucleotide binding region [chemical binding]; other site
278137013805	helicase superfamily c-terminal domain; Region: HELICc; smart00490
278137013806	Helicase associated domain (HA2); Region: HA2; pfam04408
278137013807	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
278137013808	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
278137013809	Uncharacterized conserved protein [Function unknown]; Region: COG0397
278137013810	hypothetical protein; Validated; Region: PRK00029
278137013811	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
278137013812	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
278137013813	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
278137013814	Domain of unknown function (DUF222); Region: DUF222; pfam02720
278137013815	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
278137013816	active site
278137013817	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137013818	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137013819	hypothetical protein; Provisional; Region: PRK06062
278137013820	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
278137013821	inhibitor-cofactor binding pocket; inhibition site
278137013822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137013823	catalytic residue [active]
278137013824	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
278137013825	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137013826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137013827	metal binding site [ion binding]; metal-binding site
278137013828	active site
278137013829	I-site; other site
278137013830	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
278137013831	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
278137013832	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
278137013833	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
278137013834	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
278137013835	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
278137013836	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
278137013837	MOSC domain; Region: MOSC; pfam03473
278137013838	Mechanosensitive ion channel; Region: MS_channel; pfam00924
278137013839	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
278137013840	Phosphotransferase enzyme family; Region: APH; pfam01636
278137013841	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
278137013842	putative active site [active]
278137013843	putative CoA binding site [chemical binding]; other site
278137013844	nudix motif; other site
278137013845	metal binding site [ion binding]; metal-binding site
278137013846	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
278137013847	putative methyltransferase; Provisional; Region: PRK14967
278137013848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
278137013849	Cutinase; Region: Cutinase; pfam01083
278137013850	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
278137013851	intracellular protease, PfpI family; Region: PfpI; TIGR01382
278137013852	proposed catalytic triad [active]
278137013853	conserved cys residue [active]
278137013854	Transcriptional regulators [Transcription]; Region: MarR; COG1846
278137013855	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
278137013856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137013857	H+ Antiporter protein; Region: 2A0121; TIGR00900
278137013858	putative substrate translocation pore; other site
278137013859	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
278137013860	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
278137013861	B12 binding domain; Region: B12-binding_2; pfam02607
278137013862	B12 binding domain; Region: B12-binding; pfam02310
278137013863	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
278137013864	anti sigma factor interaction site; other site
278137013865	regulatory phosphorylation site [posttranslational modification]; other site
278137013866	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
278137013867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
278137013868	NAD(P) binding site [chemical binding]; other site
278137013869	active site
278137013870	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
278137013871	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
278137013872	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
278137013873	active site
278137013874	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
278137013875	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
278137013876	active site
278137013877	NAD binding site [chemical binding]; other site
278137013878	metal binding site [ion binding]; metal-binding site
278137013879	classical (c) SDRs; Region: SDR_c; cd05233
278137013880	NAD(P) binding site [chemical binding]; other site
278137013881	active site
278137013882	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
278137013883	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
278137013884	putative active site [active]
278137013885	putative metal binding site [ion binding]; other site
278137013886	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
278137013887	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
278137013888	active site
278137013889	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
278137013890	catalytic triad [active]
278137013891	dimer interface [polypeptide binding]; other site
278137013892	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
278137013893	hydrophobic ligand binding site; other site
278137013894	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
278137013895	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
278137013896	putative acyl-acceptor binding pocket; other site
278137013897	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
278137013898	ATP binding site [chemical binding]; other site
278137013899	putative Mg++ binding site [ion binding]; other site
278137013900	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
278137013901	nucleotide binding region [chemical binding]; other site
278137013902	ATP-binding site [chemical binding]; other site
278137013903	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
278137013904	Short C-terminal domain; Region: SHOCT; pfam09851
278137013905	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
278137013906	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137013907	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
278137013908	Amidase; Region: Amidase; cl11426
278137013909	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
278137013910	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
278137013911	nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323
278137013912	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
278137013913	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
278137013914	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
278137013915	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
278137013916	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
278137013917	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
278137013918	conserved cys residue [active]
278137013919	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137013920	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
278137013921	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
278137013922	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
278137013923	conserved cys residue [active]
278137013924	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
278137013925	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
278137013926	active site
278137013927	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
278137013928	Putative cyclase; Region: Cyclase; pfam04199
278137013929	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
278137013930	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
278137013931	putative active site [active]
278137013932	catalytic site [active]
278137013933	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
278137013934	putative active site [active]
278137013935	catalytic site [active]
278137013936	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
278137013937	CheB methylesterase; Region: CheB_methylest; pfam01339
278137013938	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
278137013939	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
278137013940	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
278137013941	GAF domain; Region: GAF_3; pfam13492
278137013942	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137013943	dimer interface [polypeptide binding]; other site
278137013944	phosphorylation site [posttranslational modification]
278137013945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137013946	ATP binding site [chemical binding]; other site
278137013947	Mg2+ binding site [ion binding]; other site
278137013948	G-X-G motif; other site
278137013949	Response regulator receiver domain; Region: Response_reg; pfam00072
278137013950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137013951	active site
278137013952	phosphorylation site [posttranslational modification]
278137013953	intermolecular recognition site; other site
278137013954	dimerization interface [polypeptide binding]; other site
278137013955	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
278137013956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137013957	active site
278137013958	phosphorylation site [posttranslational modification]
278137013959	intermolecular recognition site; other site
278137013960	dimerization interface [polypeptide binding]; other site
278137013961	Response regulator receiver domain; Region: Response_reg; pfam00072
278137013962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137013963	active site
278137013964	phosphorylation site [posttranslational modification]
278137013965	intermolecular recognition site; other site
278137013966	dimerization interface [polypeptide binding]; other site
278137013967	Response regulator receiver domain; Region: Response_reg; pfam00072
278137013968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137013969	active site
278137013970	phosphorylation site [posttranslational modification]
278137013971	intermolecular recognition site; other site
278137013972	dimerization interface [polypeptide binding]; other site
278137013973	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
278137013974	PAS domain; Region: PAS_9; pfam13426
278137013975	putative active site [active]
278137013976	heme pocket [chemical binding]; other site
278137013977	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
278137013978	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
278137013979	metal binding site [ion binding]; metal-binding site
278137013980	active site
278137013981	I-site; other site
278137013982	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
278137013983	EVE domain; Region: EVE; cl00728
278137013984	Domain of unknown function (DUF385); Region: DUF385; pfam04075
278137013985	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
278137013986	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
278137013987	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
278137013988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137013989	Walker A/P-loop; other site
278137013990	ATP binding site [chemical binding]; other site
278137013991	Q-loop/lid; other site
278137013992	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137013993	ABC transporter signature motif; other site
278137013994	ABC transporter signature motif; other site
278137013995	Walker B; other site
278137013996	Walker B; other site
278137013997	D-loop; other site
278137013998	H-loop/switch region; other site
278137013999	ABC transporter; Region: ABC_tran_2; pfam12848
278137014000	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
278137014001	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
278137014002	active site
278137014003	catalytic site [active]
278137014004	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
278137014005	active site 2 [active]
278137014006	active site 1 [active]
278137014007	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
278137014008	Predicted membrane protein [Function unknown]; Region: COG2860
278137014009	UPF0126 domain; Region: UPF0126; pfam03458
278137014010	UPF0126 domain; Region: UPF0126; pfam03458
278137014011	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
278137014012	heme binding pocket [chemical binding]; other site
278137014013	heme ligand [chemical binding]; other site
278137014014	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
278137014015	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
278137014016	active site
278137014017	FMN binding site [chemical binding]; other site
278137014018	substrate binding site [chemical binding]; other site
278137014019	3Fe-4S cluster binding site [ion binding]; other site
278137014020	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
278137014021	catalytic residues [active]
278137014022	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
278137014023	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
278137014024	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
278137014025	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
278137014026	active site residue [active]
278137014027	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
278137014028	active site residue [active]
278137014029	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
278137014030	active site residue [active]
278137014031	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
278137014032	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
278137014033	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
278137014034	putative homotetramer interface [polypeptide binding]; other site
278137014035	putative homodimer interface [polypeptide binding]; other site
278137014036	putative allosteric switch controlling residues; other site
278137014037	putative metal binding site [ion binding]; other site
278137014038	putative homodimer-homodimer interface [polypeptide binding]; other site
278137014039	Domain of unknown function DUF302; Region: DUF302; pfam03625
278137014040	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
278137014041	Rhodanese-like domain; Region: Rhodanese; pfam00581
278137014042	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
278137014043	active site residue [active]
278137014044	Predicted membrane protein [Function unknown]; Region: COG2149
278137014045	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
278137014046	classical (c) SDRs; Region: SDR_c; cd05233
278137014047	NAD(P) binding site [chemical binding]; other site
278137014048	active site
278137014049	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137014050	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137014051	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
278137014052	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
278137014053	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
278137014054	Walker A/P-loop; other site
278137014055	ATP binding site [chemical binding]; other site
278137014056	Q-loop/lid; other site
278137014057	ABC transporter signature motif; other site
278137014058	Walker B; other site
278137014059	D-loop; other site
278137014060	H-loop/switch region; other site
278137014061	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
278137014062	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
278137014063	Walker A/P-loop; other site
278137014064	ATP binding site [chemical binding]; other site
278137014065	Q-loop/lid; other site
278137014066	ABC transporter signature motif; other site
278137014067	Walker B; other site
278137014068	D-loop; other site
278137014069	H-loop/switch region; other site
278137014070	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
278137014071	hypothetical protein; Provisional; Region: PRK06547
278137014072	AAA domain; Region: AAA_18; pfam13238
278137014073	Domain of unknown function (DUF309); Region: DUF309; pfam03745
278137014074	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
278137014075	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
278137014076	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
278137014077	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
278137014078	Predicted membrane protein [Function unknown]; Region: COG4270
278137014079	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
278137014080	MarR family; Region: MarR; pfam01047
278137014081	Transcriptional regulators [Transcription]; Region: GntR; COG1802
278137014082	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137014083	DNA-binding site [nucleotide binding]; DNA binding site
278137014084	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
278137014085	FAD binding domain; Region: FAD_binding_4; pfam01565
278137014086	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
278137014087	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
278137014088	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
278137014089	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
278137014090	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137014091	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
278137014092	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137014093	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
278137014094	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
278137014095	Uncharacterized conserved protein [Function unknown]; Region: COG2966
278137014096	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
278137014097	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
278137014098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137014099	metabolite-proton symporter; Region: 2A0106; TIGR00883
278137014100	putative substrate translocation pore; other site
278137014101	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
278137014102	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
278137014103	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
278137014104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137014105	ABC transporter signature motif; other site
278137014106	Walker B; other site
278137014107	D-loop; other site
278137014108	H-loop/switch region; other site
278137014109	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
278137014110	Walker A/P-loop; other site
278137014111	ATP binding site [chemical binding]; other site
278137014112	Q-loop/lid; other site
278137014113	ABC transporter signature motif; other site
278137014114	Walker B; other site
278137014115	D-loop; other site
278137014116	H-loop/switch region; other site
278137014117	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
278137014118	lycopene cyclase; Region: lycopene_cycl; TIGR01789
278137014119	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
278137014120	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
278137014121	substrate binding site [chemical binding]; other site
278137014122	ATP binding site [chemical binding]; other site
278137014123	Survival protein SurE; Region: SurE; pfam01975
278137014124	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
278137014125	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
278137014126	Transposase; Region: DDE_Tnp_ISL3; pfam01610
278137014127	multidrug resistance protein MdtH; Provisional; Region: PRK11646
278137014128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
278137014129	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
278137014130	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
278137014131	dimer interface [polypeptide binding]; other site
278137014132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
278137014133	catalytic residue [active]
278137014134	Peptidase family M48; Region: Peptidase_M48; cl12018
278137014135	Penicillinase repressor; Region: Pencillinase_R; pfam03965
278137014136	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
278137014137	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
278137014138	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137014139	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
278137014140	active site
278137014141	motif I; other site
278137014142	motif II; other site
278137014143	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
278137014144	putative homotetramer interface [polypeptide binding]; other site
278137014145	putative homodimer interface [polypeptide binding]; other site
278137014146	putative allosteric switch controlling residues; other site
278137014147	putative metal binding site [ion binding]; other site
278137014148	putative homodimer-homodimer interface [polypeptide binding]; other site
278137014149	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
278137014150	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
278137014151	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
278137014152	metal-binding site [ion binding]
278137014153	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
278137014154	Soluble P-type ATPase [General function prediction only]; Region: COG4087
278137014155	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
278137014156	metal-binding site [ion binding]
278137014157	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
278137014158	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
278137014159	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
278137014160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
278137014161	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
278137014162	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137014163	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137014164	putative transposase OrfB; Reviewed; Region: PHA02517
278137014165	HTH-like domain; Region: HTH_21; pfam13276
278137014166	Integrase core domain; Region: rve; pfam00665
278137014167	Integrase core domain; Region: rve_3; cl15866
278137014168	Transposase; Region: HTH_Tnp_1; cl17663
278137014169	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
278137014170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
278137014171	active site
278137014172	phosphorylation site [posttranslational modification]
278137014173	intermolecular recognition site; other site
278137014174	dimerization interface [polypeptide binding]; other site
278137014175	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
278137014176	DNA binding site [nucleotide binding]
278137014177	HAMP domain; Region: HAMP; pfam00672
278137014178	dimerization interface [polypeptide binding]; other site
278137014179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
278137014180	dimer interface [polypeptide binding]; other site
278137014181	phosphorylation site [posttranslational modification]
278137014182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137014183	ATP binding site [chemical binding]; other site
278137014184	Mg2+ binding site [ion binding]; other site
278137014185	G-X-G motif; other site
278137014186	Domain of unknown function (DUF305); Region: DUF305; pfam03713
278137014187	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
278137014188	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
278137014189	NlpC/P60 family; Region: NLPC_P60; pfam00877
278137014190	Fic family protein [Function unknown]; Region: COG3177
278137014191	Fic/DOC family; Region: Fic; pfam02661
278137014192	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
278137014193	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
278137014194	non-specific DNA binding site [nucleotide binding]; other site
278137014195	salt bridge; other site
278137014196	sequence-specific DNA binding site [nucleotide binding]; other site
278137014197	TniQ; Region: TniQ; pfam06527
278137014198	AAA domain; Region: AAA_22; pfam13401
278137014199	Helix-turn-helix domain; Region: HTH_28; pfam13518
278137014200	Integrase core domain; Region: rve; pfam00665
278137014201	TniQ; Region: TniQ; pfam06527
278137014202	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
278137014203	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
278137014204	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
278137014205	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
278137014206	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
278137014207	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
278137014208	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
278137014209	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
278137014210	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
278137014211	HsdM N-terminal domain; Region: HsdM_N; pfam12161
278137014212	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
278137014213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137014214	S-adenosylmethionine binding site [chemical binding]; other site
278137014215	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
278137014216	Methyltransferase domain; Region: Methyltransf_26; pfam13659
278137014217	LabA_like proteins; Region: LabA_like; cd06167
278137014218	putative metal binding site [ion binding]; other site
278137014219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
278137014220	ATP binding site [chemical binding]; other site
278137014221	Mg2+ binding site [ion binding]; other site
278137014222	G-X-G motif; other site
278137014223	TniQ; Region: TniQ; pfam06527
278137014224	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
278137014225	AAA domain; Region: AAA_22; pfam13401
278137014226	Bacterial TniB protein; Region: TniB; pfam05621
278137014227	Helix-turn-helix domain; Region: HTH_28; pfam13518
278137014228	Integrase core domain; Region: rve; pfam00665
278137014229	Integrase core domain; Region: rve_3; cl15866
278137014230	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
278137014231	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
278137014232	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
278137014233	Walker A motif; other site
278137014234	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
278137014235	Hom_end-associated Hint; Region: Hom_end_hint; pfam05203
278137014236	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
278137014237	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
278137014238	Walker A motif; other site
278137014239	ATP binding site [chemical binding]; other site
278137014240	Walker B motif; other site
278137014241	DNA binding loops [nucleotide binding]
278137014242	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
278137014243	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
278137014244	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
278137014245	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
278137014246	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
278137014247	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
278137014248	dimer interface [polypeptide binding]; other site
278137014249	ssDNA binding site [nucleotide binding]; other site
278137014250	tetramer (dimer of dimers) interface [polypeptide binding]; other site
278137014251	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
278137014252	Predicted integral membrane protein [Function unknown]; Region: COG5650
278137014253	Transglycosylase; Region: Transgly; pfam00912
278137014254	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
278137014255	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
278137014256	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
278137014257	Predicted transcriptional regulators [Transcription]; Region: COG1695
278137014258	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
278137014259	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
278137014260	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
278137014261	hypothetical protein; Provisional; Region: PRK01346
278137014262	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
278137014263	Coenzyme A binding pocket [chemical binding]; other site
278137014264	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
278137014265	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
278137014266	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
278137014267	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
278137014268	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
278137014269	Transcriptional regulators [Transcription]; Region: GntR; COG1802
278137014270	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
278137014271	DNA-binding site [nucleotide binding]; DNA binding site
278137014272	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
278137014273	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
278137014274	substrate binding pocket [chemical binding]; other site
278137014275	membrane-bound complex binding site; other site
278137014276	hinge residues; other site
278137014277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
278137014278	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
278137014279	dimer interface [polypeptide binding]; other site
278137014280	conserved gate region; other site
278137014281	putative PBP binding loops; other site
278137014282	ABC-ATPase subunit interface; other site
278137014283	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
278137014284	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
278137014285	Walker A/P-loop; other site
278137014286	ATP binding site [chemical binding]; other site
278137014287	Q-loop/lid; other site
278137014288	ABC transporter signature motif; other site
278137014289	Walker B; other site
278137014290	D-loop; other site
278137014291	H-loop/switch region; other site
278137014292	MarR family; Region: MarR; pfam01047
278137014293	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
278137014294	short chain dehydrogenase; Provisional; Region: PRK08219
278137014295	classical (c) SDRs; Region: SDR_c; cd05233
278137014296	NAD(P) binding site [chemical binding]; other site
278137014297	active site
278137014298	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
278137014299	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
278137014300	HIGH motif; other site
278137014301	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
278137014302	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
278137014303	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
278137014304	active site
278137014305	KMSKS motif; other site
278137014306	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
278137014307	tRNA binding surface [nucleotide binding]; other site
278137014308	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
278137014309	hypothetical protein; Validated; Region: PRK00228
278137014310	H+ Antiporter protein; Region: 2A0121; TIGR00900
278137014311	TIGR03084 family protein; Region: TIGR03084
278137014312	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
278137014313	Wyosine base formation; Region: Wyosine_form; pfam08608
278137014314	CHAP domain; Region: CHAP; cl17642
278137014315	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
278137014316	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
278137014317	active site
278137014318	NTP binding site [chemical binding]; other site
278137014319	metal binding triad [ion binding]; metal-binding site
278137014320	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
278137014321	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
278137014322	Zn2+ binding site [ion binding]; other site
278137014323	Mg2+ binding site [ion binding]; other site
278137014324	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
278137014325	active site
278137014326	Ap6A binding site [chemical binding]; other site
278137014327	nudix motif; other site
278137014328	metal binding site [ion binding]; metal-binding site
278137014329	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
278137014330	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
278137014331	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
278137014332	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
278137014333	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
278137014334	DNA binding residues [nucleotide binding]
278137014335	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
278137014336	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
278137014337	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
278137014338	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
278137014339	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
278137014340	catalytic residues [active]
278137014341	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
278137014342	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
278137014343	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
278137014344	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
278137014345	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
278137014346	active site
278137014347	metal binding site [ion binding]; metal-binding site
278137014348	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
278137014349	ParB-like nuclease domain; Region: ParBc; pfam02195
278137014350	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
278137014351	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137014352	P-loop; other site
278137014353	Magnesium ion binding site [ion binding]; other site
278137014354	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
278137014355	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
278137014356	Magnesium ion binding site [ion binding]; other site
278137014357	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
278137014358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
278137014359	S-adenosylmethionine binding site [chemical binding]; other site
278137014360	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
278137014361	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
278137014362	G-X-X-G motif; other site
278137014363	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
278137014364	RxxxH motif; other site
278137014365	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
278137014366	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
278137014367	Uncharacterized conserved protein [Function unknown]; Region: COG0759
278137014368	ribonuclease P; Reviewed; Region: rnpA; PRK00588
278137014369	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399