-- dump date 20140619_152259 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1232724000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1232724000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724000003 Walker A motif; other site 1232724000004 ATP binding site [chemical binding]; other site 1232724000005 Walker B motif; other site 1232724000006 arginine finger; other site 1232724000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1232724000008 DnaA box-binding interface [nucleotide binding]; other site 1232724000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1232724000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1232724000011 putative DNA binding surface [nucleotide binding]; other site 1232724000012 dimer interface [polypeptide binding]; other site 1232724000013 beta-clamp/clamp loader binding surface; other site 1232724000014 beta-clamp/translesion DNA polymerase binding surface; other site 1232724000015 recombination protein F; Reviewed; Region: recF; PRK00064 1232724000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1232724000017 Walker A/P-loop; other site 1232724000018 ATP binding site [chemical binding]; other site 1232724000019 Q-loop/lid; other site 1232724000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724000021 ABC transporter signature motif; other site 1232724000022 Walker B; other site 1232724000023 D-loop; other site 1232724000024 H-loop/switch region; other site 1232724000025 hypothetical protein; Provisional; Region: PRK03195 1232724000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1232724000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724000028 Mg2+ binding site [ion binding]; other site 1232724000029 G-X-G motif; other site 1232724000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1232724000031 anchoring element; other site 1232724000032 dimer interface [polypeptide binding]; other site 1232724000033 ATP binding site [chemical binding]; other site 1232724000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1232724000035 active site 1232724000036 putative metal-binding site [ion binding]; other site 1232724000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1232724000038 DNA gyrase subunit A; Validated; Region: PRK05560 1232724000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1232724000040 CAP-like domain; other site 1232724000041 active site 1232724000042 primary dimer interface [polypeptide binding]; other site 1232724000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232724000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232724000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232724000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232724000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232724000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232724000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1232724000050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000052 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000053 Cytochrome P450; Region: p450; cl12078 1232724000054 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1232724000055 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1232724000056 active site 1232724000057 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1232724000058 putative septation inhibitor protein; Reviewed; Region: PRK00159 1232724000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1232724000060 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1232724000061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1232724000062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1232724000063 glutamine binding [chemical binding]; other site 1232724000064 catalytic triad [active] 1232724000065 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1232724000066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724000067 active site 1232724000068 ATP binding site [chemical binding]; other site 1232724000069 substrate binding site [chemical binding]; other site 1232724000070 activation loop (A-loop); other site 1232724000071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1232724000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232724000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232724000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232724000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232724000076 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724000077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724000078 active site 1232724000079 ATP binding site [chemical binding]; other site 1232724000080 substrate binding site [chemical binding]; other site 1232724000081 activation loop (A-loop); other site 1232724000082 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1232724000083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232724000084 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1232724000085 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1232724000086 active site 1232724000087 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724000088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724000089 phosphopeptide binding site; other site 1232724000090 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1232724000091 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724000092 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724000093 phosphopeptide binding site; other site 1232724000094 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724000095 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1232724000096 DinB superfamily; Region: DinB_2; pfam12867 1232724000097 acyl carrier protein; Validated; Region: PRK05883 1232724000098 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1232724000099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724000100 acyl-activating enzyme (AAE) consensus motif; other site 1232724000101 AMP binding site [chemical binding]; other site 1232724000102 active site 1232724000103 CoA binding site [chemical binding]; other site 1232724000104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1232724000105 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1232724000106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724000107 Coenzyme A binding pocket [chemical binding]; other site 1232724000108 Pirin-related protein [General function prediction only]; Region: COG1741 1232724000109 Pirin; Region: Pirin; pfam02678 1232724000110 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1232724000111 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000112 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724000113 active site 1232724000114 Transcription factor WhiB; Region: Whib; pfam02467 1232724000115 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724000116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724000117 non-specific DNA binding site [nucleotide binding]; other site 1232724000118 salt bridge; other site 1232724000119 sequence-specific DNA binding site [nucleotide binding]; other site 1232724000120 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232724000121 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232724000122 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1232724000123 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1232724000124 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1232724000125 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1232724000126 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1232724000127 TIGR03084 family protein; Region: TIGR03084 1232724000128 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724000129 Wyosine base formation; Region: Wyosine_form; pfam08608 1232724000130 H+ Antiporter protein; Region: 2A0121; TIGR00900 1232724000131 hypothetical protein; Validated; Region: PRK00228 1232724000132 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1232724000133 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1232724000134 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724000135 active site 1232724000136 HIGH motif; other site 1232724000137 nucleotide binding site [chemical binding]; other site 1232724000138 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1232724000139 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724000140 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724000141 active site 1232724000142 KMSKS motif; other site 1232724000143 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1232724000144 tRNA binding surface [nucleotide binding]; other site 1232724000145 short chain dehydrogenase; Provisional; Region: PRK08219 1232724000146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000147 NAD(P) binding site [chemical binding]; other site 1232724000148 active site 1232724000149 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724000150 MarR family; Region: MarR; pfam01047 1232724000151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724000152 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1232724000153 Walker A/P-loop; other site 1232724000154 ATP binding site [chemical binding]; other site 1232724000155 Q-loop/lid; other site 1232724000156 ABC transporter signature motif; other site 1232724000157 Walker B; other site 1232724000158 D-loop; other site 1232724000159 H-loop/switch region; other site 1232724000160 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232724000161 substrate binding pocket [chemical binding]; other site 1232724000162 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1232724000163 membrane-bound complex binding site; other site 1232724000164 hinge residues; other site 1232724000165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724000166 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1232724000167 dimer interface [polypeptide binding]; other site 1232724000168 conserved gate region; other site 1232724000169 putative PBP binding loops; other site 1232724000170 ABC-ATPase subunit interface; other site 1232724000171 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232724000172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724000173 DNA-binding site [nucleotide binding]; DNA binding site 1232724000174 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1232724000175 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724000176 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724000177 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1232724000178 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1232724000179 active site 1232724000180 FMN binding site [chemical binding]; other site 1232724000181 substrate binding site [chemical binding]; other site 1232724000182 putative catalytic residue [active] 1232724000183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000184 NAD(P) binding site [chemical binding]; other site 1232724000185 active site 1232724000186 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724000187 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1232724000188 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1232724000189 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724000190 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724000191 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1232724000192 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1232724000193 Predicted transcriptional regulators [Transcription]; Region: COG1695 1232724000194 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1232724000195 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1232724000196 Transglycosylase; Region: Transgly; pfam00912 1232724000197 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1232724000198 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232724000199 Predicted integral membrane protein [Function unknown]; Region: COG5650 1232724000200 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1232724000201 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1232724000202 conserved cys residue [active] 1232724000203 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1232724000204 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1232724000205 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1232724000206 dimer interface [polypeptide binding]; other site 1232724000207 ssDNA binding site [nucleotide binding]; other site 1232724000208 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232724000209 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1232724000210 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1232724000211 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1232724000212 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1232724000213 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1232724000214 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1232724000215 Walker A motif; other site 1232724000216 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1232724000217 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1232724000218 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1232724000219 ATP binding site [chemical binding]; other site 1232724000220 Walker B motif; other site 1232724000221 DNA binding loops [nucleotide binding] 1232724000222 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1232724000223 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1232724000224 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1232724000225 Ligand Binding Site [chemical binding]; other site 1232724000226 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724000227 Homeodomain-like domain; Region: HTH_23; pfam13384 1232724000228 Winged helix-turn helix; Region: HTH_29; pfam13551 1232724000229 Integrase core domain; Region: rve; pfam00665 1232724000230 Integrase core domain; Region: rve_3; cl15866 1232724000231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724000232 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232724000233 Integrase core domain; Region: rve; pfam00665 1232724000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724000235 Walker A motif; other site 1232724000236 ATP binding site [chemical binding]; other site 1232724000237 Walker B motif; other site 1232724000238 AAA domain; Region: AAA_22; pfam13401 1232724000239 Bacterial TniB protein; Region: TniB; pfam05621 1232724000240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1232724000241 TniQ; Region: TniQ; pfam06527 1232724000242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724000243 sequence-specific DNA binding site [nucleotide binding]; other site 1232724000244 salt bridge; other site 1232724000245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724000246 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1232724000247 Walker A motif; other site 1232724000248 ATP binding site [chemical binding]; other site 1232724000249 Walker B motif; other site 1232724000250 arginine finger; other site 1232724000251 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1232724000252 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1232724000253 Walker A/P-loop; other site 1232724000254 ATP binding site [chemical binding]; other site 1232724000255 Q-loop/lid; other site 1232724000256 ABC transporter signature motif; other site 1232724000257 Walker B; other site 1232724000258 D-loop; other site 1232724000259 H-loop/switch region; other site 1232724000260 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724000261 catalytic core [active] 1232724000262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724000263 classical (c) SDRs; Region: SDR_c; cd05233 1232724000264 NAD(P) binding site [chemical binding]; other site 1232724000265 active site 1232724000266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724000268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000269 active site 1232724000270 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724000271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724000272 oxyanion hole (OAH) forming residues; other site 1232724000273 trimer interface [polypeptide binding]; other site 1232724000274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1232724000275 oxyanion hole (OAH) forming residues; other site 1232724000276 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1232724000277 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1232724000278 putative active site [active] 1232724000279 putative catalytic site [active] 1232724000280 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1232724000281 frameshift; Acetyl-CoA hydrolase/transferase 1232724000282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000284 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232724000285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000286 NAD(P) binding site [chemical binding]; other site 1232724000287 active site 1232724000288 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1232724000289 putative active site [active] 1232724000290 putative CoA binding site [chemical binding]; other site 1232724000291 nudix motif; other site 1232724000292 metal binding site [ion binding]; metal-binding site 1232724000293 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1232724000294 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724000295 cyclase homology domain; Region: CHD; cd07302 1232724000296 nucleotidyl binding site; other site 1232724000297 metal binding site [ion binding]; metal-binding site 1232724000298 dimer interface [polypeptide binding]; other site 1232724000299 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1232724000300 active site 1232724000301 catalytic residues [active] 1232724000302 metal binding site [ion binding]; metal-binding site 1232724000303 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724000304 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724000305 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1232724000306 TPP-binding site [chemical binding]; other site 1232724000307 PYR/PP interface [polypeptide binding]; other site 1232724000308 dimer interface [polypeptide binding]; other site 1232724000309 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1232724000310 TPP binding site [chemical binding]; other site 1232724000311 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1232724000312 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232724000313 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1232724000314 FMN-binding pocket [chemical binding]; other site 1232724000315 flavin binding motif; other site 1232724000316 phosphate binding motif [ion binding]; other site 1232724000317 beta-alpha-beta structure motif; other site 1232724000318 NAD binding pocket [chemical binding]; other site 1232724000319 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724000320 catalytic loop [active] 1232724000321 iron binding site [ion binding]; other site 1232724000322 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000323 Cytochrome P450; Region: p450; cl12078 1232724000324 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232724000325 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724000326 active site 1232724000327 metal binding site [ion binding]; metal-binding site 1232724000328 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232724000329 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724000330 Berberine and berberine like; Region: BBE; pfam08031 1232724000331 hypothetical protein; Provisional; Region: PRK06847 1232724000332 hypothetical protein; Provisional; Region: PRK07236 1232724000333 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1232724000334 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1232724000335 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1232724000336 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1232724000337 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1232724000338 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1232724000339 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232724000340 active site 1232724000341 metal binding site [ion binding]; metal-binding site 1232724000342 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232724000343 active site 1232724000344 metal binding site [ion binding]; metal-binding site 1232724000345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724000346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000347 active site 1232724000348 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1232724000349 active site 1232724000350 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1232724000351 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724000352 acyl-activating enzyme (AAE) consensus motif; other site 1232724000353 AMP binding site [chemical binding]; other site 1232724000354 active site 1232724000355 CoA binding site [chemical binding]; other site 1232724000356 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 1232724000357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000359 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1232724000360 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232724000361 E3 interaction surface; other site 1232724000362 lipoyl attachment site [posttranslational modification]; other site 1232724000363 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232724000364 E3 interaction surface; other site 1232724000365 lipoyl attachment site [posttranslational modification]; other site 1232724000366 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232724000367 YCII-related domain; Region: YCII; cl00999 1232724000368 Permease; Region: Permease; pfam02405 1232724000369 Permease; Region: Permease; pfam02405 1232724000370 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000371 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232724000372 mce related protein; Region: MCE; pfam02470 1232724000373 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000374 mce related protein; Region: MCE; pfam02470 1232724000375 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000376 mce related protein; Region: MCE; pfam02470 1232724000377 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000378 mce related protein; Region: MCE; pfam02470 1232724000379 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232724000380 mce related protein; Region: MCE; pfam02470 1232724000381 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724000382 classical (c) SDRs; Region: SDR_c; cd05233 1232724000383 NAD(P) binding site [chemical binding]; other site 1232724000384 active site 1232724000385 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724000386 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724000387 substrate binding site [chemical binding]; other site 1232724000388 oxyanion hole (OAH) forming residues; other site 1232724000389 trimer interface [polypeptide binding]; other site 1232724000390 enoyl-CoA hydratase; Provisional; Region: PRK06688 1232724000391 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724000392 substrate binding site [chemical binding]; other site 1232724000393 oxyanion hole (OAH) forming residues; other site 1232724000394 trimer interface [polypeptide binding]; other site 1232724000395 enoyl-CoA hydratase; Provisional; Region: PRK06688 1232724000396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724000397 substrate binding site [chemical binding]; other site 1232724000398 oxyanion hole (OAH) forming residues; other site 1232724000399 trimer interface [polypeptide binding]; other site 1232724000400 AMP-binding domain protein; Validated; Region: PRK08315 1232724000401 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724000402 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1232724000403 acyl-activating enzyme (AAE) consensus motif; other site 1232724000404 acyl-activating enzyme (AAE) consensus motif; other site 1232724000405 putative AMP binding site [chemical binding]; other site 1232724000406 putative active site [active] 1232724000407 putative CoA binding site [chemical binding]; other site 1232724000408 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1232724000409 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1232724000410 iron-sulfur cluster [ion binding]; other site 1232724000411 [2Fe-2S] cluster binding site [ion binding]; other site 1232724000412 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1232724000413 putative alpha subunit interface [polypeptide binding]; other site 1232724000414 putative active site [active] 1232724000415 putative substrate binding site [chemical binding]; other site 1232724000416 Fe binding site [ion binding]; other site 1232724000417 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1232724000418 inter-subunit interface; other site 1232724000419 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1232724000420 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724000421 dimer interface [polypeptide binding]; other site 1232724000422 active site 1232724000423 hypothetical protein; Provisional; Region: PRK04262 1232724000424 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724000425 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724000426 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 1232724000427 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724000428 active site 1232724000429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000431 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724000432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000433 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1232724000434 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724000435 putative active site [active] 1232724000436 putative substrate binding site [chemical binding]; other site 1232724000437 ATP binding site [chemical binding]; other site 1232724000438 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1232724000439 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1232724000440 Walker A/P-loop; other site 1232724000441 ATP binding site [chemical binding]; other site 1232724000442 Q-loop/lid; other site 1232724000443 ABC transporter signature motif; other site 1232724000444 Walker B; other site 1232724000445 D-loop; other site 1232724000446 H-loop/switch region; other site 1232724000447 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1232724000448 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1232724000449 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724000450 acyl-activating enzyme (AAE) consensus motif; other site 1232724000451 putative AMP binding site [chemical binding]; other site 1232724000452 putative active site [active] 1232724000453 putative CoA binding site [chemical binding]; other site 1232724000454 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000455 Cytochrome P450; Region: p450; cl12078 1232724000456 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1232724000457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000458 NAD(P) binding site [chemical binding]; other site 1232724000459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000460 active site 1232724000461 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1232724000462 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1232724000463 NAD(P) binding site [chemical binding]; other site 1232724000464 catalytic residues [active] 1232724000465 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1232724000466 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1232724000467 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1232724000468 4Fe-4S binding domain; Region: Fer4; pfam00037 1232724000469 ferredoxin-NADP+ reductase; Region: PLN02852 1232724000470 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1232724000471 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724000472 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724000473 active site 2 [active] 1232724000474 active site 1 [active] 1232724000475 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1232724000476 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1232724000477 NAD(P) binding site [chemical binding]; other site 1232724000478 catalytic residues [active] 1232724000479 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1232724000480 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724000481 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724000482 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724000483 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1232724000484 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1232724000485 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000486 Cytochrome P450; Region: p450; cl12078 1232724000487 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724000488 classical (c) SDRs; Region: SDR_c; cd05233 1232724000489 NAD(P) binding site [chemical binding]; other site 1232724000490 active site 1232724000491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000493 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724000494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000495 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232724000496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000497 NAD(P) binding site [chemical binding]; other site 1232724000498 active site 1232724000499 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1232724000500 putative hydrophobic ligand binding site [chemical binding]; other site 1232724000501 protein interface [polypeptide binding]; other site 1232724000502 gate; other site 1232724000503 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724000504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000505 NAD(P) binding site [chemical binding]; other site 1232724000506 active site 1232724000507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000508 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1232724000509 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724000510 FMN binding site [chemical binding]; other site 1232724000511 substrate binding site [chemical binding]; other site 1232724000512 putative catalytic residue [active] 1232724000513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724000514 enoyl-CoA hydratase; Provisional; Region: PRK06495 1232724000515 substrate binding site [chemical binding]; other site 1232724000516 oxyanion hole (OAH) forming residues; other site 1232724000517 trimer interface [polypeptide binding]; other site 1232724000518 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232724000519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000520 NAD(P) binding site [chemical binding]; other site 1232724000521 active site 1232724000522 Ecdysteroid kinase; Region: EcKinase; cl17738 1232724000523 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724000524 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232724000525 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1232724000526 NAD(P) binding site [chemical binding]; other site 1232724000527 catalytic residues [active] 1232724000528 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1232724000529 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724000530 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1232724000531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000532 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232724000533 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000534 Cytochrome P450; Region: p450; cl12078 1232724000535 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724000536 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724000537 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724000538 acyl-activating enzyme (AAE) consensus motif; other site 1232724000539 acyl-activating enzyme (AAE) consensus motif; other site 1232724000540 putative AMP binding site [chemical binding]; other site 1232724000541 putative active site [active] 1232724000542 putative CoA binding site [chemical binding]; other site 1232724000543 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724000544 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724000545 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1232724000546 NAD(P) binding site [chemical binding]; other site 1232724000547 catalytic residues [active] 1232724000548 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1232724000549 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724000550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724000551 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724000552 acyl-activating enzyme (AAE) consensus motif; other site 1232724000553 putative AMP binding site [chemical binding]; other site 1232724000554 putative active site [active] 1232724000555 acyl-activating enzyme (AAE) consensus motif; other site 1232724000556 putative CoA binding site [chemical binding]; other site 1232724000557 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724000558 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724000559 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724000560 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000561 Cytochrome P450; Region: p450; cl12078 1232724000562 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1232724000563 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232724000564 phosphate binding site [ion binding]; other site 1232724000565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000568 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724000569 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1232724000570 NAD binding site [chemical binding]; other site 1232724000571 homodimer interface [polypeptide binding]; other site 1232724000572 active site 1232724000573 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724000574 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724000575 acyl-activating enzyme (AAE) consensus motif; other site 1232724000576 AMP binding site [chemical binding]; other site 1232724000577 active site 1232724000578 CoA binding site [chemical binding]; other site 1232724000579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000581 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232724000582 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1232724000583 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724000584 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000585 Cytochrome P450; Region: p450; cl12078 1232724000586 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1232724000587 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232724000588 NAD binding site [chemical binding]; other site 1232724000589 catalytic Zn binding site [ion binding]; other site 1232724000590 substrate binding site [chemical binding]; other site 1232724000591 structural Zn binding site [ion binding]; other site 1232724000592 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000593 Cytochrome P450; Region: p450; cl12078 1232724000594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000595 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724000596 active site 1232724000597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724000599 active site 1232724000600 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1232724000601 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1232724000602 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724000603 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724000604 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724000605 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724000606 acyl-activating enzyme (AAE) consensus motif; other site 1232724000607 putative AMP binding site [chemical binding]; other site 1232724000608 putative active site [active] 1232724000609 putative CoA binding site [chemical binding]; other site 1232724000610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000611 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232724000612 enoyl-CoA hydratase; Provisional; Region: PRK07658 1232724000613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724000614 substrate binding site [chemical binding]; other site 1232724000615 oxyanion hole (OAH) forming residues; other site 1232724000616 trimer interface [polypeptide binding]; other site 1232724000617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000618 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232724000619 NAD(P) binding site [chemical binding]; other site 1232724000620 active site 1232724000621 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000622 Cytochrome P450; Region: p450; cl12078 1232724000623 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1232724000624 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232724000625 phosphate binding site [ion binding]; other site 1232724000626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724000627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000629 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1232724000630 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1232724000631 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1232724000632 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232724000633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000634 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724000635 active site 1232724000636 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232724000637 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724000638 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724000639 putative active site [active] 1232724000640 putative substrate binding site [chemical binding]; other site 1232724000641 ATP binding site [chemical binding]; other site 1232724000642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000644 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232724000645 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1232724000646 Transposase domain (DUF772); Region: DUF772; pfam05598 1232724000647 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1232724000648 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1232724000649 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724000650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000651 Ecdysteroid kinase; Region: EcKinase; cl17738 1232724000652 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724000653 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232724000654 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724000655 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232724000656 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724000657 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1232724000658 dimer interface [polypeptide binding]; other site 1232724000659 active site 1232724000660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724000662 active site 1232724000663 short chain dehydrogenase; Provisional; Region: PRK08251 1232724000664 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1232724000665 putative NAD(P) binding site [chemical binding]; other site 1232724000666 active site 1232724000667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000669 Transport protein; Region: actII; TIGR00833 1232724000670 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724000671 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232724000672 DNA-binding site [nucleotide binding]; DNA binding site 1232724000673 RNA-binding motif; other site 1232724000674 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724000675 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724000676 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1232724000677 classical (c) SDRs; Region: SDR_c; cd05233 1232724000678 NAD(P) binding site [chemical binding]; other site 1232724000679 active site 1232724000680 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724000681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000682 NAD(P) binding site [chemical binding]; other site 1232724000683 active site 1232724000684 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000685 Cytochrome P450; Region: p450; cl12078 1232724000686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000687 short chain dehydrogenase; Provisional; Region: PRK08303 1232724000688 NAD(P) binding site [chemical binding]; other site 1232724000689 active site 1232724000690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000692 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1232724000693 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1232724000694 putative dimer interface [polypeptide binding]; other site 1232724000695 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724000696 classical (c) SDRs; Region: SDR_c; cd05233 1232724000697 NAD(P) binding site [chemical binding]; other site 1232724000698 active site 1232724000699 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232724000700 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724000701 Berberine and berberine like; Region: BBE; pfam08031 1232724000702 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232724000703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232724000704 ligand binding site [chemical binding]; other site 1232724000705 flexible hinge region; other site 1232724000706 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1232724000707 putative switch regulator; other site 1232724000708 non-specific DNA interactions [nucleotide binding]; other site 1232724000709 DNA binding site [nucleotide binding] 1232724000710 sequence specific DNA binding site [nucleotide binding]; other site 1232724000711 putative cAMP binding site [chemical binding]; other site 1232724000712 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724000713 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724000714 PGAP1-like protein; Region: PGAP1; pfam07819 1232724000715 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1232724000716 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1232724000717 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1232724000718 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232724000719 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724000720 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1232724000721 active site 1232724000722 Permease; Region: Permease; pfam02405 1232724000723 Permease; Region: Permease; pfam02405 1232724000724 mce related protein; Region: MCE; pfam02470 1232724000725 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724000726 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232724000727 mce related protein; Region: MCE; pfam02470 1232724000728 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000729 mce related protein; Region: MCE; pfam02470 1232724000730 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000731 mce related protein; Region: MCE; pfam02470 1232724000732 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000733 mce related protein; Region: MCE; pfam02470 1232724000734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232724000735 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724000736 mce related protein; Region: MCE; pfam02470 1232724000737 Mannan-binding protein; Region: MVL; pfam12151 1232724000738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000742 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1232724000743 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1232724000744 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724000745 PPE family; Region: PPE; pfam00823 1232724000746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724000747 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724000748 S-adenosylmethionine binding site [chemical binding]; other site 1232724000749 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724000750 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724000751 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724000752 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1232724000753 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1232724000754 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1232724000755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724000756 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724000757 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1232724000758 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1232724000759 putative ligand binding site [chemical binding]; other site 1232724000760 NAD binding site [chemical binding]; other site 1232724000761 catalytic site [active] 1232724000762 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1232724000763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1232724000764 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724000765 Cytochrome P450; Region: p450; cl12078 1232724000766 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1232724000767 metal ion-dependent adhesion site (MIDAS); other site 1232724000768 MoxR-like ATPases [General function prediction only]; Region: COG0714 1232724000769 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1232724000770 Walker A motif; other site 1232724000771 ATP binding site [chemical binding]; other site 1232724000772 Walker B motif; other site 1232724000773 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1232724000774 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1232724000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000776 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724000777 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724000778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724000779 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232724000780 putative substrate translocation pore; other site 1232724000781 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724000782 Fe binding site [ion binding]; other site 1232724000783 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724000784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724000785 S-adenosylmethionine binding site [chemical binding]; other site 1232724000786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1232724000787 active site 1232724000788 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1232724000789 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1232724000790 putative active site [active] 1232724000791 putative CoA binding site [chemical binding]; other site 1232724000792 nudix motif; other site 1232724000793 metal binding site [ion binding]; metal-binding site 1232724000794 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1232724000795 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1232724000796 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724000797 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724000798 Predicted transcriptional regulators [Transcription]; Region: COG1695 1232724000799 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1232724000800 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1232724000801 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724000802 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1232724000803 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724000804 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1232724000805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000806 hypothetical protein; Provisional; Region: PRK01346 1232724000807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724000808 Coenzyme A binding pocket [chemical binding]; other site 1232724000809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724000811 active site 1232724000812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724000815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724000816 dimer interface [polypeptide binding]; other site 1232724000817 phosphorylation site [posttranslational modification] 1232724000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724000819 ATP binding site [chemical binding]; other site 1232724000820 Mg2+ binding site [ion binding]; other site 1232724000821 G-X-G motif; other site 1232724000822 PPE family; Region: PPE; pfam00823 1232724000823 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1232724000824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1232724000825 EspG family; Region: ESX-1_EspG; pfam14011 1232724000826 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1232724000827 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1232724000828 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1232724000829 catalytic residues [active] 1232724000830 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1232724000831 catalytic residues [active] 1232724000832 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1232724000833 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1232724000834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724000835 Walker A motif; other site 1232724000836 ATP binding site [chemical binding]; other site 1232724000837 Walker B motif; other site 1232724000838 arginine finger; other site 1232724000839 Domain of unknown function (DUF385); Region: DUF385; cl04387 1232724000840 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1232724000841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724000842 NAD(P) binding site [chemical binding]; other site 1232724000843 active site 1232724000844 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1232724000845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724000846 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1232724000847 DNA binding residues [nucleotide binding] 1232724000848 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1232724000849 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1232724000850 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1232724000851 active site 1232724000852 dimer interface [polypeptide binding]; other site 1232724000853 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1232724000854 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1232724000855 active site 1232724000856 FMN binding site [chemical binding]; other site 1232724000857 substrate binding site [chemical binding]; other site 1232724000858 3Fe-4S cluster binding site [ion binding]; other site 1232724000859 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1232724000860 domain interface; other site 1232724000861 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1232724000862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000863 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1232724000864 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724000865 hypothetical protein; Provisional; Region: PRK07945 1232724000866 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1232724000867 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1232724000868 active site 1232724000869 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1232724000870 DNA polymerase IV; Validated; Region: PRK03858 1232724000871 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1232724000872 active site 1232724000873 DNA binding site [nucleotide binding] 1232724000874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724000875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000876 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724000877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724000878 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1232724000879 CopC domain; Region: CopC; pfam04234 1232724000880 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1232724000881 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1232724000882 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1232724000883 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1232724000884 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1232724000885 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1232724000886 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1232724000887 putative active site [active] 1232724000888 catalytic site [active] 1232724000889 putative metal binding site [ion binding]; other site 1232724000890 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1232724000891 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1232724000892 prephenate dehydratase; Provisional; Region: PRK11898 1232724000893 Prephenate dehydratase; Region: PDT; pfam00800 1232724000894 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1232724000895 putative L-Phe binding site [chemical binding]; other site 1232724000896 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724000897 catalytic core [active] 1232724000898 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1232724000899 Septum formation; Region: Septum_form; pfam13845 1232724000900 Septum formation; Region: Septum_form; pfam13845 1232724000901 seryl-tRNA synthetase; Provisional; Region: PRK05431 1232724000902 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1232724000903 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1232724000904 dimer interface [polypeptide binding]; other site 1232724000905 active site 1232724000906 motif 1; other site 1232724000907 motif 2; other site 1232724000908 motif 3; other site 1232724000909 Cupin domain; Region: Cupin_2; cl17218 1232724000910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724000911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232724000912 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232724000913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724000914 S-adenosylmethionine binding site [chemical binding]; other site 1232724000915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724000916 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1232724000917 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724000918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724000919 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724000920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000921 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1232724000922 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232724000923 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232724000924 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1232724000925 iron-sulfur cluster [ion binding]; other site 1232724000926 [2Fe-2S] cluster binding site [ion binding]; other site 1232724000927 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724000928 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232724000929 putative acyl-acceptor binding pocket; other site 1232724000930 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724000931 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232724000932 putative acyl-acceptor binding pocket; other site 1232724000933 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724000934 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232724000935 putative acyl-acceptor binding pocket; other site 1232724000936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724000937 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1232724000938 active site 1232724000939 motif I; other site 1232724000940 motif II; other site 1232724000941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724000942 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1232724000943 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1232724000944 amidase catalytic site [active] 1232724000945 Zn binding residues [ion binding]; other site 1232724000946 substrate binding site [chemical binding]; other site 1232724000947 LGFP repeat; Region: LGFP; pfam08310 1232724000948 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1232724000949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724000950 UDP-galactopyranose mutase; Region: GLF; pfam03275 1232724000951 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232724000952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1232724000953 active site 1232724000954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232724000955 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1232724000956 Predicted esterase [General function prediction only]; Region: COG0627 1232724000957 Putative esterase; Region: Esterase; pfam00756 1232724000958 Cutinase; Region: Cutinase; pfam01083 1232724000959 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1232724000960 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1232724000961 acyl-activating enzyme (AAE) consensus motif; other site 1232724000962 active site 1232724000963 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724000964 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724000965 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1232724000966 active site 1232724000967 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232724000968 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724000969 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724000970 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1232724000971 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232724000972 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232724000973 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724000974 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1232724000975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724000976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724000977 DNA binding residues [nucleotide binding] 1232724000978 RibD C-terminal domain; Region: RibD_C; cl17279 1232724000979 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724000980 active site 1232724000981 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724000982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232724000983 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1232724000984 ligand binding site [chemical binding]; other site 1232724000985 flexible hinge region; other site 1232724000986 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1232724000987 putative switch regulator; other site 1232724000988 non-specific DNA interactions [nucleotide binding]; other site 1232724000989 DNA binding site [nucleotide binding] 1232724000990 sequence specific DNA binding site [nucleotide binding]; other site 1232724000991 putative cAMP binding site [chemical binding]; other site 1232724000992 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724000993 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724000994 phosphopeptide binding site; other site 1232724000995 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1232724000996 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1232724000997 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724000998 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724000999 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1232724001000 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1232724001001 putative hydrophobic ligand binding site [chemical binding]; other site 1232724001002 CLM binding site; other site 1232724001003 L1 loop; other site 1232724001004 DNA binding site [nucleotide binding] 1232724001005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724001006 putative DNA binding site [nucleotide binding]; other site 1232724001007 putative Zn2+ binding site [ion binding]; other site 1232724001008 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1232724001009 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1232724001010 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1232724001011 short chain dehydrogenase; Provisional; Region: PRK07904 1232724001012 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232724001013 NAD(P) binding site [chemical binding]; other site 1232724001014 active site 1232724001015 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232724001016 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724001017 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1232724001018 Predicted membrane protein [Function unknown]; Region: COG2246 1232724001019 GtrA-like protein; Region: GtrA; pfam04138 1232724001020 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1232724001021 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1232724001022 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724001023 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724001024 active site 1232724001025 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1232724001026 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1232724001027 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232724001028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232724001029 active site 1232724001030 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1232724001031 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1232724001032 Walker A/P-loop; other site 1232724001033 ATP binding site [chemical binding]; other site 1232724001034 Q-loop/lid; other site 1232724001035 ABC transporter signature motif; other site 1232724001036 Walker B; other site 1232724001037 D-loop; other site 1232724001038 H-loop/switch region; other site 1232724001039 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1232724001040 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1232724001041 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724001042 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724001043 catalytic residue [active] 1232724001044 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1232724001045 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1232724001046 NAD(P) binding site [chemical binding]; other site 1232724001047 eRF1 domain 3; Region: eRF1_3; pfam03465 1232724001048 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724001049 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724001050 enoyl-CoA hydratase; Provisional; Region: PRK06142 1232724001051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724001052 substrate binding site [chemical binding]; other site 1232724001053 oxyanion hole (OAH) forming residues; other site 1232724001054 trimer interface [polypeptide binding]; other site 1232724001055 TIGR03086 family protein; Region: TIGR03086 1232724001056 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724001057 GXWXG protein; Region: GXWXG; pfam14231 1232724001058 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1232724001059 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1232724001060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724001061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724001062 homodimer interface [polypeptide binding]; other site 1232724001063 catalytic residue [active] 1232724001064 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724001065 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724001066 putative active site [active] 1232724001067 putative substrate binding site [chemical binding]; other site 1232724001068 ATP binding site [chemical binding]; other site 1232724001069 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724001070 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724001071 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724001072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724001073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724001074 active site 1232724001075 phosphorylation site [posttranslational modification] 1232724001076 intermolecular recognition site; other site 1232724001077 dimerization interface [polypeptide binding]; other site 1232724001078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724001079 DNA binding site [nucleotide binding] 1232724001080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724001081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1232724001082 dimerization interface [polypeptide binding]; other site 1232724001083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724001084 dimer interface [polypeptide binding]; other site 1232724001085 phosphorylation site [posttranslational modification] 1232724001086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724001087 ATP binding site [chemical binding]; other site 1232724001088 Mg2+ binding site [ion binding]; other site 1232724001089 G-X-G motif; other site 1232724001090 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1232724001091 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1232724001092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724001093 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232724001094 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1232724001095 NAD(P) binding site [chemical binding]; other site 1232724001096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724001097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724001098 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001099 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001100 active site 1232724001101 short chain dehydrogenase; Provisional; Region: PRK07035 1232724001102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724001103 NAD(P) binding site [chemical binding]; other site 1232724001104 active site 1232724001105 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724001106 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724001107 putative active site [active] 1232724001108 putative substrate binding site [chemical binding]; other site 1232724001109 ATP binding site [chemical binding]; other site 1232724001110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724001111 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724001112 catalytic core [active] 1232724001113 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724001114 putative active site [active] 1232724001115 putative substrate binding site [chemical binding]; other site 1232724001116 ATP binding site [chemical binding]; other site 1232724001117 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1232724001118 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1232724001119 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1232724001120 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1232724001121 Walker A/P-loop; other site 1232724001122 ATP binding site [chemical binding]; other site 1232724001123 Q-loop/lid; other site 1232724001124 ABC transporter signature motif; other site 1232724001125 Walker B; other site 1232724001126 D-loop; other site 1232724001127 H-loop/switch region; other site 1232724001128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1232724001129 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1232724001130 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1232724001131 prephenate dehydrogenase; Validated; Region: PRK06545 1232724001132 prephenate dehydrogenase; Validated; Region: PRK08507 1232724001133 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1232724001134 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1232724001135 nucleoside/Zn binding site; other site 1232724001136 dimer interface [polypeptide binding]; other site 1232724001137 catalytic motif [active] 1232724001138 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1232724001139 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1232724001140 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1232724001141 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1232724001142 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1232724001143 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1232724001144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724001145 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724001146 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724001147 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232724001148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724001149 DNA-binding site [nucleotide binding]; DNA binding site 1232724001150 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1232724001151 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1232724001152 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1232724001153 active site 1232724001154 non-prolyl cis peptide bond; other site 1232724001155 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724001156 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724001157 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1232724001158 pyruvate carboxylase; Reviewed; Region: PRK12999 1232724001159 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232724001160 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724001161 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232724001162 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1232724001163 active site 1232724001164 catalytic residues [active] 1232724001165 metal binding site [ion binding]; metal-binding site 1232724001166 homodimer binding site [polypeptide binding]; other site 1232724001167 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232724001168 carboxyltransferase (CT) interaction site; other site 1232724001169 biotinylation site [posttranslational modification]; other site 1232724001170 citrate synthase; Provisional; Region: PRK14033 1232724001171 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1232724001172 dimer interface [polypeptide binding]; other site 1232724001173 active site 1232724001174 citrylCoA binding site [chemical binding]; other site 1232724001175 oxalacetate/citrate binding site [chemical binding]; other site 1232724001176 coenzyme A binding site [chemical binding]; other site 1232724001177 catalytic triad [active] 1232724001178 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1232724001179 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232724001180 tetramer interface [polypeptide binding]; other site 1232724001181 active site 1232724001182 Mg2+/Mn2+ binding site [ion binding]; other site 1232724001183 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1232724001184 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724001185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724001186 non-specific DNA binding site [nucleotide binding]; other site 1232724001187 salt bridge; other site 1232724001188 sequence-specific DNA binding site [nucleotide binding]; other site 1232724001189 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1232724001190 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1232724001191 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1232724001192 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1232724001193 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232724001194 substrate binding site [chemical binding]; other site 1232724001195 ATP binding site [chemical binding]; other site 1232724001196 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1232724001197 dimerization interface [polypeptide binding]; other site 1232724001198 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1232724001199 NAD binding site [chemical binding]; other site 1232724001200 ligand binding site [chemical binding]; other site 1232724001201 catalytic site [active] 1232724001202 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724001203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724001204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724001205 classical (c) SDRs; Region: SDR_c; cd05233 1232724001206 NAD(P) binding site [chemical binding]; other site 1232724001207 active site 1232724001208 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1232724001209 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724001210 active site 1232724001211 metal binding site [ion binding]; metal-binding site 1232724001212 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724001213 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724001214 short chain dehydrogenase; Provisional; Region: PRK07856 1232724001215 classical (c) SDRs; Region: SDR_c; cd05233 1232724001216 NAD(P) binding site [chemical binding]; other site 1232724001217 active site 1232724001218 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724001219 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724001220 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 1232724001221 nudix motif; other site 1232724001222 haloalkane dehalogenase; Provisional; Region: PRK00870 1232724001223 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724001224 Cytochrome P450; Region: p450; cl12078 1232724001225 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724001226 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724001227 active site 1232724001228 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1232724001229 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1232724001230 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1232724001231 active site 1232724001232 DNA binding site [nucleotide binding] 1232724001233 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1232724001234 DNA binding site [nucleotide binding] 1232724001235 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1232724001236 nucleotide binding site [chemical binding]; other site 1232724001237 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1232724001238 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724001239 Cytochrome P450; Region: p450; cl12078 1232724001240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724001241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724001242 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1232724001243 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1232724001244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724001245 NAD(P) binding site [chemical binding]; other site 1232724001246 active site 1232724001247 Cutinase; Region: Cutinase; pfam01083 1232724001248 CsbD-like; Region: CsbD; pfam05532 1232724001249 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724001250 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724001251 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724001252 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724001253 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1232724001254 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724001255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724001256 catalytic residue [active] 1232724001257 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1232724001258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724001259 Walker A motif; other site 1232724001260 ATP binding site [chemical binding]; other site 1232724001261 Walker B motif; other site 1232724001262 arginine finger; other site 1232724001263 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1232724001264 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724001265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724001266 S-adenosylmethionine binding site [chemical binding]; other site 1232724001267 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232724001268 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724001269 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1232724001270 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1232724001271 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1232724001272 active site 1232724001273 metal binding site [ion binding]; metal-binding site 1232724001274 hypothetical protein; Validated; Region: PRK00153 1232724001275 recombination protein RecR; Reviewed; Region: recR; PRK00076 1232724001276 RecR protein; Region: RecR; pfam02132 1232724001277 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1232724001278 putative active site [active] 1232724001279 putative metal-binding site [ion binding]; other site 1232724001280 tetramer interface [polypeptide binding]; other site 1232724001281 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1232724001282 catalytic triad [active] 1232724001283 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1232724001284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232724001285 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1232724001286 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1232724001287 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1232724001288 active site 1232724001289 catalytic site [active] 1232724001290 substrate binding site [chemical binding]; other site 1232724001291 2-isopropylmalate synthase; Validated; Region: PRK03739 1232724001292 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1232724001293 active site 1232724001294 catalytic residues [active] 1232724001295 metal binding site [ion binding]; metal-binding site 1232724001296 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1232724001297 aspartate kinase; Reviewed; Region: PRK06635 1232724001298 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1232724001299 putative nucleotide binding site [chemical binding]; other site 1232724001300 putative catalytic residues [active] 1232724001301 putative Mg ion binding site [ion binding]; other site 1232724001302 putative aspartate binding site [chemical binding]; other site 1232724001303 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1232724001304 putative allosteric regulatory site; other site 1232724001305 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1232724001306 putative allosteric regulatory residue; other site 1232724001307 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1232724001308 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1232724001309 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1232724001310 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724001311 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 1232724001312 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1232724001313 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1232724001314 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1232724001315 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1232724001316 putative active site [active] 1232724001317 putative dimer interface [polypeptide binding]; other site 1232724001318 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1232724001319 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1232724001320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724001321 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1232724001322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724001323 catalytic residue [active] 1232724001324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724001325 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724001326 S-adenosylmethionine binding site [chemical binding]; other site 1232724001327 glycerol kinase; Provisional; Region: glpK; PRK00047 1232724001328 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1232724001329 N- and C-terminal domain interface [polypeptide binding]; other site 1232724001330 active site 1232724001331 MgATP binding site [chemical binding]; other site 1232724001332 catalytic site [active] 1232724001333 metal binding site [ion binding]; metal-binding site 1232724001334 putative homotetramer interface [polypeptide binding]; other site 1232724001335 glycerol binding site [chemical binding]; other site 1232724001336 homodimer interface [polypeptide binding]; other site 1232724001337 Predicted transcriptional regulators [Transcription]; Region: COG1695 1232724001338 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1232724001339 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1232724001340 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1232724001341 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1232724001342 Protein of unknown function DUF58; Region: DUF58; pfam01882 1232724001343 MoxR-like ATPases [General function prediction only]; Region: COG0714 1232724001344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724001345 Walker A motif; other site 1232724001346 ATP binding site [chemical binding]; other site 1232724001347 Walker B motif; other site 1232724001348 arginine finger; other site 1232724001349 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1232724001350 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1232724001351 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1232724001352 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724001353 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1232724001354 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1232724001355 proposed catalytic triad [active] 1232724001356 conserved cys residue [active] 1232724001357 putative methyltransferase; Provisional; Region: PRK14967 1232724001358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724001359 S-adenosylmethionine binding site [chemical binding]; other site 1232724001360 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1232724001361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1232724001362 PAS domain; Region: PAS_9; pfam13426 1232724001363 putative active site [active] 1232724001364 heme pocket [chemical binding]; other site 1232724001365 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1232724001366 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1232724001367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1232724001368 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1232724001369 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1232724001370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724001371 ATP binding site [chemical binding]; other site 1232724001372 Mg2+ binding site [ion binding]; other site 1232724001373 G-X-G motif; other site 1232724001374 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1232724001375 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1232724001376 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1232724001377 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724001378 anti sigma factor interaction site; other site 1232724001379 regulatory phosphorylation site [posttranslational modification]; other site 1232724001380 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1232724001381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724001382 motif II; other site 1232724001383 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1232724001384 Restriction endonuclease; Region: Mrr_cat; pfam04471 1232724001385 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1232724001386 GAF domain; Region: GAF; pfam01590 1232724001387 ANTAR domain; Region: ANTAR; pfam03861 1232724001388 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232724001389 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1232724001390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724001391 catalytic residue [active] 1232724001392 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1232724001393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1232724001394 putative active site [active] 1232724001395 putative metal binding site [ion binding]; other site 1232724001396 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1232724001397 Transglycosylase; Region: Transgly; pfam00912 1232724001398 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1232724001399 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1232724001400 Transcription factor WhiB; Region: Whib; pfam02467 1232724001401 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1232724001402 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1232724001403 DTAP/Switch II; other site 1232724001404 Switch I; other site 1232724001405 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1232724001406 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1232724001407 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1232724001408 P loop; other site 1232724001409 Nucleotide binding site [chemical binding]; other site 1232724001410 DTAP/Switch II; other site 1232724001411 Switch I; other site 1232724001412 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1232724001413 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1232724001414 homotrimer interaction site [polypeptide binding]; other site 1232724001415 putative active site [active] 1232724001416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724001417 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232724001418 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232724001419 ligand binding site [chemical binding]; other site 1232724001420 flexible hinge region; other site 1232724001421 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1232724001422 putative switch regulator; other site 1232724001423 non-specific DNA interactions [nucleotide binding]; other site 1232724001424 DNA binding site [nucleotide binding] 1232724001425 sequence specific DNA binding site [nucleotide binding]; other site 1232724001426 putative cAMP binding site [chemical binding]; other site 1232724001427 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1232724001428 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1232724001429 minor groove reading motif; other site 1232724001430 helix-hairpin-helix signature motif; other site 1232724001431 substrate binding pocket [chemical binding]; other site 1232724001432 active site 1232724001433 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1232724001434 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1232724001435 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232724001436 catalytic residues [active] 1232724001437 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1232724001438 putative active site [active] 1232724001439 putative CoA binding site [chemical binding]; other site 1232724001440 nudix motif; other site 1232724001441 metal binding site [ion binding]; metal-binding site 1232724001442 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1232724001443 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232724001444 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724001445 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1232724001446 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232724001447 acetyl-CoA synthetase; Provisional; Region: PRK00174 1232724001448 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1232724001449 active site 1232724001450 CoA binding site [chemical binding]; other site 1232724001451 acyl-activating enzyme (AAE) consensus motif; other site 1232724001452 AMP binding site [chemical binding]; other site 1232724001453 acetate binding site [chemical binding]; other site 1232724001454 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1232724001455 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1232724001456 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1232724001457 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1232724001458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724001459 dimer interface [polypeptide binding]; other site 1232724001460 conserved gate region; other site 1232724001461 ABC-ATPase subunit interface; other site 1232724001462 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1232724001463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724001464 dimer interface [polypeptide binding]; other site 1232724001465 conserved gate region; other site 1232724001466 putative PBP binding loops; other site 1232724001467 ABC-ATPase subunit interface; other site 1232724001468 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1232724001469 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232724001470 Walker A/P-loop; other site 1232724001471 ATP binding site [chemical binding]; other site 1232724001472 Q-loop/lid; other site 1232724001473 ABC transporter signature motif; other site 1232724001474 Walker B; other site 1232724001475 D-loop; other site 1232724001476 H-loop/switch region; other site 1232724001477 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232724001478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232724001479 Walker A/P-loop; other site 1232724001480 ATP binding site [chemical binding]; other site 1232724001481 Q-loop/lid; other site 1232724001482 ABC transporter signature motif; other site 1232724001483 Walker B; other site 1232724001484 D-loop; other site 1232724001485 H-loop/switch region; other site 1232724001486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232724001487 Fic family protein [Function unknown]; Region: COG3177 1232724001488 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1232724001489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724001490 motif II; other site 1232724001491 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1232724001492 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1232724001493 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1232724001494 hexamer interface [polypeptide binding]; other site 1232724001495 Walker B motif; other site 1232724001496 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1232724001497 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1232724001498 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1232724001499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724001500 ATP binding site [chemical binding]; other site 1232724001501 putative Mg++ binding site [ion binding]; other site 1232724001502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724001503 nucleotide binding region [chemical binding]; other site 1232724001504 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1232724001505 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232724001506 DNA-binding site [nucleotide binding]; DNA binding site 1232724001507 RNA-binding motif; other site 1232724001508 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1232724001509 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1232724001510 active site 1232724001511 interdomain interaction site; other site 1232724001512 putative metal-binding site [ion binding]; other site 1232724001513 nucleotide binding site [chemical binding]; other site 1232724001514 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1232724001515 domain I; other site 1232724001516 phosphate binding site [ion binding]; other site 1232724001517 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1232724001518 domain II; other site 1232724001519 domain III; other site 1232724001520 nucleotide binding site [chemical binding]; other site 1232724001521 DNA binding groove [nucleotide binding] 1232724001522 catalytic site [active] 1232724001523 domain IV; other site 1232724001524 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1232724001525 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1232724001526 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1232724001527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232724001528 dimerization interface [polypeptide binding]; other site 1232724001529 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724001530 cyclase homology domain; Region: CHD; cd07302 1232724001531 nucleotidyl binding site; other site 1232724001532 metal binding site [ion binding]; metal-binding site 1232724001533 dimer interface [polypeptide binding]; other site 1232724001534 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1232724001535 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1232724001536 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724001537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724001538 NAD(P) binding site [chemical binding]; other site 1232724001539 active site 1232724001540 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232724001541 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1232724001542 Ligand binding site; other site 1232724001543 Putative Catalytic site; other site 1232724001544 DXD motif; other site 1232724001545 Protein of unknown function (DUF475); Region: DUF475; pfam04332 1232724001546 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1232724001547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1232724001548 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1232724001549 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1232724001550 dimer interface [polypeptide binding]; other site 1232724001551 substrate binding site [chemical binding]; other site 1232724001552 metal binding sites [ion binding]; metal-binding site 1232724001553 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1232724001554 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1232724001555 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1232724001556 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1232724001557 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1232724001558 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1232724001559 Ligand Binding Site [chemical binding]; other site 1232724001560 TilS substrate binding domain; Region: TilS; pfam09179 1232724001561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232724001562 active site 1232724001563 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1232724001564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724001565 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724001566 salt bridge; other site 1232724001567 non-specific DNA binding site [nucleotide binding]; other site 1232724001568 sequence-specific DNA binding site [nucleotide binding]; other site 1232724001569 PE family; Region: PE; pfam00934 1232724001570 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724001571 PPE family; Region: PPE; pfam00823 1232724001572 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724001573 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724001574 active site 1232724001575 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724001576 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1232724001577 putative NAD(P) binding site [chemical binding]; other site 1232724001578 catalytic Zn binding site [ion binding]; other site 1232724001579 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724001580 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232724001581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724001582 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724001583 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232724001584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724001585 active site 1232724001586 metal binding site [ion binding]; metal-binding site 1232724001587 FtsH Extracellular; Region: FtsH_ext; pfam06480 1232724001588 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1232724001589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724001590 Walker A motif; other site 1232724001591 ATP binding site [chemical binding]; other site 1232724001592 Walker B motif; other site 1232724001593 arginine finger; other site 1232724001594 Peptidase family M41; Region: Peptidase_M41; pfam01434 1232724001595 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1232724001596 homodecamer interface [polypeptide binding]; other site 1232724001597 GTP cyclohydrolase I; Provisional; Region: PLN03044 1232724001598 active site 1232724001599 putative catalytic site residues [active] 1232724001600 zinc binding site [ion binding]; other site 1232724001601 GTP-CH-I/GFRP interaction surface; other site 1232724001602 dihydropteroate synthase; Region: DHPS; TIGR01496 1232724001603 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1232724001604 substrate binding pocket [chemical binding]; other site 1232724001605 dimer interface [polypeptide binding]; other site 1232724001606 inhibitor binding site; inhibition site 1232724001607 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1232724001608 active site 1232724001609 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1232724001610 catalytic center binding site [active] 1232724001611 ATP binding site [chemical binding]; other site 1232724001612 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1232724001613 Rossmann-like domain; Region: Rossmann-like; pfam10727 1232724001614 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1232724001615 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1232724001616 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1232724001617 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1232724001618 active site 1232724001619 ATP-binding site [chemical binding]; other site 1232724001620 pantoate-binding site; other site 1232724001621 HXXH motif; other site 1232724001622 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1232724001623 tetramerization interface [polypeptide binding]; other site 1232724001624 active site 1232724001625 pantothenate kinase; Reviewed; Region: PRK13318 1232724001626 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1232724001627 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1232724001628 dimer interface [polypeptide binding]; other site 1232724001629 putative anticodon binding site; other site 1232724001630 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232724001631 motif 1; other site 1232724001632 dimer interface [polypeptide binding]; other site 1232724001633 active site 1232724001634 motif 2; other site 1232724001635 motif 3; other site 1232724001636 Lsr2; Region: Lsr2; pfam11774 1232724001637 Clp amino terminal domain; Region: Clp_N; pfam02861 1232724001638 Clp amino terminal domain; Region: Clp_N; pfam02861 1232724001639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724001640 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1232724001641 Walker A motif; other site 1232724001642 ATP binding site [chemical binding]; other site 1232724001643 Walker B motif; other site 1232724001644 arginine finger; other site 1232724001645 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1232724001646 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1232724001647 Walker B motif; other site 1232724001648 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1232724001649 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1232724001650 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1232724001651 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1232724001652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724001653 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1232724001654 catalytic site [active] 1232724001655 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1232724001656 minor groove reading motif; other site 1232724001657 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1232724001658 helix-hairpin-helix signature motif; other site 1232724001659 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1232724001660 active site clefts [active] 1232724001661 zinc binding site [ion binding]; other site 1232724001662 dimer interface [polypeptide binding]; other site 1232724001663 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1232724001664 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1232724001665 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1232724001666 DNA repair protein RadA; Provisional; Region: PRK11823 1232724001667 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1232724001668 Walker A motif/ATP binding site; other site 1232724001669 ATP binding site [chemical binding]; other site 1232724001670 Walker B motif; other site 1232724001671 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1232724001672 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1232724001673 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1232724001674 substrate binding site; other site 1232724001675 dimer interface; other site 1232724001676 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1232724001677 homotrimer interaction site [polypeptide binding]; other site 1232724001678 zinc binding site [ion binding]; other site 1232724001679 CDP-binding sites; other site 1232724001680 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1232724001681 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724001682 active site 1232724001683 HIGH motif; other site 1232724001684 nucleotide binding site [chemical binding]; other site 1232724001685 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1232724001686 KMSKS motif; other site 1232724001687 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1232724001688 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232724001689 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1232724001690 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232724001691 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1232724001692 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1232724001693 active site 1232724001694 catalytic site [active] 1232724001695 metal binding site [ion binding]; metal-binding site 1232724001696 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1232724001697 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1232724001698 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232724001699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232724001700 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1232724001701 putative active site [active] 1232724001702 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724001703 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1232724001704 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1232724001705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724001706 Walker A/P-loop; other site 1232724001707 ATP binding site [chemical binding]; other site 1232724001708 Q-loop/lid; other site 1232724001709 ABC transporter signature motif; other site 1232724001710 Walker B; other site 1232724001711 D-loop; other site 1232724001712 H-loop/switch region; other site 1232724001713 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232724001714 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1232724001715 intersubunit interface [polypeptide binding]; other site 1232724001716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232724001717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232724001718 DNA binding site [nucleotide binding] 1232724001719 domain linker motif; other site 1232724001720 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1232724001721 putative dimerization interface [polypeptide binding]; other site 1232724001722 putative ligand binding site [chemical binding]; other site 1232724001723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724001724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724001725 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001726 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724001727 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001728 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001729 active site 1232724001730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001731 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001732 active site 1232724001733 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724001734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724001735 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1232724001736 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724001737 putative NAD(P) binding site [chemical binding]; other site 1232724001738 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1232724001739 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1232724001740 FAD binding pocket [chemical binding]; other site 1232724001741 FAD binding motif [chemical binding]; other site 1232724001742 phosphate binding motif [ion binding]; other site 1232724001743 beta-alpha-beta structure motif; other site 1232724001744 NAD(p) ribose binding residues [chemical binding]; other site 1232724001745 NAD binding pocket [chemical binding]; other site 1232724001746 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1232724001747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724001748 catalytic loop [active] 1232724001749 iron binding site [ion binding]; other site 1232724001750 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001751 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1232724001752 Flavin binding site [chemical binding]; other site 1232724001753 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1232724001754 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1232724001755 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1232724001756 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1232724001757 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1232724001758 active site 1232724001759 Fe binding site [ion binding]; other site 1232724001760 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1232724001761 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1232724001762 aspartate aminotransferase; Provisional; Region: PRK05764 1232724001763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724001764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724001765 homodimer interface [polypeptide binding]; other site 1232724001766 catalytic residue [active] 1232724001767 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001768 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001769 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1232724001770 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724001771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001772 active site 1232724001773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001775 active site 1232724001776 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1232724001777 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724001778 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1232724001779 acyl-activating enzyme (AAE) consensus motif; other site 1232724001780 acyl-activating enzyme (AAE) consensus motif; other site 1232724001781 putative AMP binding site [chemical binding]; other site 1232724001782 putative active site [active] 1232724001783 putative CoA binding site [chemical binding]; other site 1232724001784 CoA binding site [chemical binding]; other site 1232724001785 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001786 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001787 active site 1232724001788 short chain dehydrogenase; Provisional; Region: PRK07831 1232724001789 classical (c) SDRs; Region: SDR_c; cd05233 1232724001790 NAD(P) binding site [chemical binding]; other site 1232724001791 active site 1232724001792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724001793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724001794 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1232724001795 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1232724001796 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724001797 dimer interface [polypeptide binding]; other site 1232724001798 active site 1232724001799 Nitronate monooxygenase; Region: NMO; pfam03060 1232724001800 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724001801 FMN binding site [chemical binding]; other site 1232724001802 substrate binding site [chemical binding]; other site 1232724001803 putative catalytic residue [active] 1232724001804 Coenzyme A transferase; Region: CoA_trans; cl17247 1232724001805 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1232724001806 enoyl-CoA hydratase; Provisional; Region: PRK06495 1232724001807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724001808 substrate binding site [chemical binding]; other site 1232724001809 oxyanion hole (OAH) forming residues; other site 1232724001810 trimer interface [polypeptide binding]; other site 1232724001811 short chain dehydrogenase; Provisional; Region: PRK07856 1232724001812 classical (c) SDRs; Region: SDR_c; cd05233 1232724001813 NAD(P) binding site [chemical binding]; other site 1232724001814 active site 1232724001815 short chain dehydrogenase; Provisional; Region: PRK07791 1232724001816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724001817 NAD(P) binding site [chemical binding]; other site 1232724001818 active site 1232724001819 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724001820 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724001821 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1232724001822 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724001823 dimer interface [polypeptide binding]; other site 1232724001824 active site 1232724001825 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724001826 Cytochrome P450; Region: p450; cl12078 1232724001827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001828 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724001829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001830 active site 1232724001831 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001832 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724001833 active site 1232724001834 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232724001835 active site 1232724001836 catalytic site [active] 1232724001837 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1232724001838 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724001839 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1232724001840 putative active site [active] 1232724001841 putative catalytic site [active] 1232724001842 lipid-transfer protein; Provisional; Region: PRK07855 1232724001843 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724001844 active site 1232724001845 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1232724001846 putative active site [active] 1232724001847 enoyl-CoA hydratase; Region: PLN02864 1232724001848 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1232724001849 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1232724001850 dimer interaction site [polypeptide binding]; other site 1232724001851 substrate-binding tunnel; other site 1232724001852 active site 1232724001853 catalytic site [active] 1232724001854 substrate binding site [chemical binding]; other site 1232724001855 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1232724001856 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232724001857 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1232724001858 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1232724001859 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1232724001860 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1232724001861 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1232724001862 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1232724001863 active site 1232724001864 catalytic residues [active] 1232724001865 metal binding site [ion binding]; metal-binding site 1232724001866 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1232724001867 short chain dehydrogenase; Provisional; Region: PRK07890 1232724001868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724001869 NAD(P) binding site [chemical binding]; other site 1232724001870 active site 1232724001871 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1232724001872 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1232724001873 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724001874 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1232724001875 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1232724001876 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1232724001877 trimer interface [polypeptide binding]; other site 1232724001878 putative metal binding site [ion binding]; other site 1232724001879 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724001880 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1232724001881 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724001882 active site 1232724001883 lipid-transfer protein; Provisional; Region: PRK07937 1232724001884 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724001885 active site 1232724001886 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1232724001887 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1232724001888 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724001889 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724001890 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1232724001891 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1232724001892 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724001893 Cytochrome P450; Region: p450; cl12078 1232724001894 frameshift; Hypothetical protein 1232724001895 enoyl-CoA hydratase; Provisional; Region: PRK07799 1232724001896 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724001897 substrate binding site [chemical binding]; other site 1232724001898 oxyanion hole (OAH) forming residues; other site 1232724001899 trimer interface [polypeptide binding]; other site 1232724001900 acyl-CoA synthetase; Validated; Region: PRK07798 1232724001901 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724001902 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1232724001903 acyl-activating enzyme (AAE) consensus motif; other site 1232724001904 acyl-activating enzyme (AAE) consensus motif; other site 1232724001905 putative AMP binding site [chemical binding]; other site 1232724001906 putative active site [active] 1232724001907 putative CoA binding site [chemical binding]; other site 1232724001908 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1232724001909 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724001910 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1232724001911 hypothetical protein; Validated; Region: PRK07586 1232724001912 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232724001913 PYR/PP interface [polypeptide binding]; other site 1232724001914 dimer interface [polypeptide binding]; other site 1232724001915 TPP binding site [chemical binding]; other site 1232724001916 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1232724001917 TPP-binding site [chemical binding]; other site 1232724001918 dimer interface [polypeptide binding]; other site 1232724001919 acyl-CoA synthetase; Validated; Region: PRK07867 1232724001920 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1232724001921 acyl-activating enzyme (AAE) consensus motif; other site 1232724001922 putative AMP binding site [chemical binding]; other site 1232724001923 putative active site [active] 1232724001924 putative CoA binding site [chemical binding]; other site 1232724001925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001926 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724001927 active site 1232724001928 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724001929 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1232724001930 FAD binding site [chemical binding]; other site 1232724001931 substrate binding site [chemical binding]; other site 1232724001932 catalytic base [active] 1232724001933 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1232724001934 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1232724001935 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1232724001936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724001937 NAD(P) binding site [chemical binding]; other site 1232724001938 active site 1232724001939 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724001940 Permease; Region: Permease; pfam02405 1232724001941 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724001942 Permease; Region: Permease; pfam02405 1232724001943 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724001944 mce related protein; Region: MCE; pfam02470 1232724001945 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724001946 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724001947 mce related protein; Region: MCE; pfam02470 1232724001948 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724001949 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724001950 mce related protein; Region: MCE; pfam02470 1232724001951 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1232724001952 mce related protein; Region: MCE; pfam02470 1232724001953 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724001954 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724001955 mce related protein; Region: MCE; pfam02470 1232724001956 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724001957 mce related protein; Region: MCE; pfam02470 1232724001958 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1232724001959 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1232724001960 active site 1232724001961 homotetramer interface [polypeptide binding]; other site 1232724001962 enoyl-CoA hydratase; Provisional; Region: PRK08290 1232724001963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724001964 substrate binding site [chemical binding]; other site 1232724001965 oxyanion hole (OAH) forming residues; other site 1232724001966 trimer interface [polypeptide binding]; other site 1232724001967 short chain dehydrogenase; Provisional; Region: PRK05875 1232724001968 classical (c) SDRs; Region: SDR_c; cd05233 1232724001969 NAD(P) binding site [chemical binding]; other site 1232724001970 active site 1232724001971 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724001972 classical (c) SDRs; Region: SDR_c; cd05233 1232724001973 NAD(P) binding site [chemical binding]; other site 1232724001974 active site 1232724001975 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1232724001976 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232724001977 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1232724001978 Amidase; Region: Amidase; cl11426 1232724001979 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724001980 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1232724001981 Peptidase family S64; Region: Peptidase_S64; pfam08192 1232724001982 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1232724001983 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1232724001984 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1232724001985 catalytic residue [active] 1232724001986 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724001987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724001988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724001989 active site 1232724001990 phosphorylation site [posttranslational modification] 1232724001991 intermolecular recognition site; other site 1232724001992 dimerization interface [polypeptide binding]; other site 1232724001993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724001994 DNA binding site [nucleotide binding] 1232724001995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724001996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232724001997 dimerization interface [polypeptide binding]; other site 1232724001998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724001999 dimer interface [polypeptide binding]; other site 1232724002000 phosphorylation site [posttranslational modification] 1232724002001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724002002 ATP binding site [chemical binding]; other site 1232724002003 Mg2+ binding site [ion binding]; other site 1232724002004 G-X-G motif; other site 1232724002005 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1232724002006 nucleotide binding site/active site [active] 1232724002007 HIT family signature motif; other site 1232724002008 catalytic residue [active] 1232724002009 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1232724002010 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1232724002011 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232724002012 NAD binding site [chemical binding]; other site 1232724002013 catalytic Zn binding site [ion binding]; other site 1232724002014 substrate binding site [chemical binding]; other site 1232724002015 structural Zn binding site [ion binding]; other site 1232724002016 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1232724002017 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1232724002018 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002019 Cytochrome P450; Region: p450; cl12078 1232724002020 short chain dehydrogenase; Provisional; Region: PRK07775 1232724002021 classical (c) SDRs; Region: SDR_c; cd05233 1232724002022 NAD(P) binding site [chemical binding]; other site 1232724002023 active site 1232724002024 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002025 Cytochrome P450; Region: p450; cl12078 1232724002026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002027 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1232724002028 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1232724002029 NAD binding site [chemical binding]; other site 1232724002030 catalytic residues [active] 1232724002031 short chain dehydrogenase; Provisional; Region: PRK07774 1232724002032 classical (c) SDRs; Region: SDR_c; cd05233 1232724002033 NAD(P) binding site [chemical binding]; other site 1232724002034 active site 1232724002035 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1232724002036 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1232724002037 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1232724002038 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1232724002039 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724002040 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724002041 active site 1232724002042 catalytic tetrad [active] 1232724002043 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724002044 MarR family; Region: MarR; pfam01047 1232724002045 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1232724002046 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1232724002047 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1232724002048 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1232724002049 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1232724002050 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1232724002051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1232724002052 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1232724002053 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1232724002054 Lyase; Region: Lyase_1; pfam00206 1232724002055 tetramer interface [polypeptide binding]; other site 1232724002056 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002057 Cytochrome P450; Region: p450; cl12078 1232724002058 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1232724002059 gating phenylalanine in ion channel; other site 1232724002060 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1232724002061 ATP binding site [chemical binding]; other site 1232724002062 active site 1232724002063 substrate binding site [chemical binding]; other site 1232724002064 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1232724002065 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724002066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232724002067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724002068 putative substrate translocation pore; other site 1232724002069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724002070 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1232724002071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724002072 putative substrate translocation pore; other site 1232724002073 Predicted deacetylase [General function prediction only]; Region: COG3233 1232724002074 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1232724002075 putative active site [active] 1232724002076 putative Zn binding site [ion binding]; other site 1232724002077 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232724002078 FAD binding domain; Region: FAD_binding_2; pfam00890 1232724002079 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232724002080 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1232724002081 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1232724002082 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1232724002083 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1232724002084 putative active site [active] 1232724002085 catalytic triad [active] 1232724002086 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724002087 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724002088 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1232724002089 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1232724002090 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724002091 putative acyl-acceptor binding pocket; other site 1232724002092 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724002093 extended (e) SDRs; Region: SDR_e; cd08946 1232724002094 NAD(P) binding site [chemical binding]; other site 1232724002095 active site 1232724002096 substrate binding site [chemical binding]; other site 1232724002097 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1232724002098 Cupin domain; Region: Cupin_2; cl17218 1232724002099 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1232724002100 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724002101 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724002102 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1232724002103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724002104 motif II; other site 1232724002105 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1232724002106 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1232724002107 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724002108 Domain of unknown function (DUF427); Region: DUF427; cl00998 1232724002109 Domain of unknown function (DUF427); Region: DUF427; cl00998 1232724002110 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1232724002111 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232724002112 putative NAD(P) binding site [chemical binding]; other site 1232724002113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002116 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724002117 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724002118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1232724002119 MOSC domain; Region: MOSC; pfam03473 1232724002120 3-alpha domain; Region: 3-alpha; pfam03475 1232724002121 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1232724002122 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1232724002123 FAD binding pocket [chemical binding]; other site 1232724002124 FAD binding motif [chemical binding]; other site 1232724002125 phosphate binding motif [ion binding]; other site 1232724002126 beta-alpha-beta structure motif; other site 1232724002127 NAD binding pocket [chemical binding]; other site 1232724002128 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724002129 catalytic loop [active] 1232724002130 iron binding site [ion binding]; other site 1232724002131 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1232724002132 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1232724002133 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1232724002134 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1232724002135 active site 1232724002136 metal binding site [ion binding]; metal-binding site 1232724002137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002139 Ecdysteroid kinase; Region: EcKinase; cl17738 1232724002140 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724002141 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1232724002142 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1232724002143 dimerization interface [polypeptide binding]; other site 1232724002144 ATP binding site [chemical binding]; other site 1232724002145 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1232724002146 dimerization interface [polypeptide binding]; other site 1232724002147 ATP binding site [chemical binding]; other site 1232724002148 CAAX protease self-immunity; Region: Abi; pfam02517 1232724002149 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724002150 mce related protein; Region: MCE; pfam02470 1232724002151 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724002152 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1232724002153 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1232724002154 active site 1232724002155 tetramer interface [polypeptide binding]; other site 1232724002156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232724002157 active site 1232724002158 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1232724002159 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1232724002160 dimerization interface [polypeptide binding]; other site 1232724002161 putative ATP binding site [chemical binding]; other site 1232724002162 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1232724002163 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1232724002164 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1232724002165 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1232724002166 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1232724002167 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1232724002168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724002169 catalytic residue [active] 1232724002170 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1232724002171 heme-binding site [chemical binding]; other site 1232724002172 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1232724002173 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1232724002174 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1232724002175 active site residue [active] 1232724002176 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1232724002177 active site residue [active] 1232724002178 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1232724002179 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1232724002180 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232724002181 catalytic residues [active] 1232724002182 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1232724002183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724002184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724002185 DNA binding site [nucleotide binding] 1232724002186 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1232724002187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724002188 Coenzyme A binding pocket [chemical binding]; other site 1232724002189 PBP superfamily domain; Region: PBP_like_2; cl17296 1232724002190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724002191 dimer interface [polypeptide binding]; other site 1232724002192 conserved gate region; other site 1232724002193 putative PBP binding loops; other site 1232724002194 ABC-ATPase subunit interface; other site 1232724002195 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1232724002196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724002197 dimer interface [polypeptide binding]; other site 1232724002198 conserved gate region; other site 1232724002199 putative PBP binding loops; other site 1232724002200 ABC-ATPase subunit interface; other site 1232724002201 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1232724002202 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1232724002203 Walker A/P-loop; other site 1232724002204 ATP binding site [chemical binding]; other site 1232724002205 Q-loop/lid; other site 1232724002206 ABC transporter signature motif; other site 1232724002207 Walker B; other site 1232724002208 D-loop; other site 1232724002209 H-loop/switch region; other site 1232724002210 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1232724002211 PhoU domain; Region: PhoU; pfam01895 1232724002212 PhoU domain; Region: PhoU; pfam01895 1232724002213 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1232724002214 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232724002215 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1232724002216 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1232724002217 FMN binding site [chemical binding]; other site 1232724002218 active site 1232724002219 catalytic residues [active] 1232724002220 substrate binding site [chemical binding]; other site 1232724002221 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1232724002222 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1232724002223 homodimer interface [polypeptide binding]; other site 1232724002224 putative substrate binding pocket [chemical binding]; other site 1232724002225 diiron center [ion binding]; other site 1232724002226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1232724002228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724002229 dimerization interface [polypeptide binding]; other site 1232724002230 putative DNA binding site [nucleotide binding]; other site 1232724002231 putative Zn2+ binding site [ion binding]; other site 1232724002232 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1232724002233 nucleoside/Zn binding site; other site 1232724002234 dimer interface [polypeptide binding]; other site 1232724002235 catalytic motif [active] 1232724002236 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724002237 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724002238 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1232724002239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232724002240 active site 1232724002241 DNA binding site [nucleotide binding] 1232724002242 Int/Topo IB signature motif; other site 1232724002243 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1232724002244 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1232724002245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724002246 DNA-binding site [nucleotide binding]; DNA binding site 1232724002247 UTRA domain; Region: UTRA; pfam07702 1232724002248 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724002249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002252 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724002253 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724002254 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1232724002255 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1232724002256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002259 Cytochrome P450; Region: p450; cl12078 1232724002260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002262 Abi-like protein; Region: Abi_2; pfam07751 1232724002263 flagellin; Reviewed; Region: PRK08411 1232724002264 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724002265 classical (c) SDRs; Region: SDR_c; cd05233 1232724002266 NAD(P) binding site [chemical binding]; other site 1232724002267 active site 1232724002268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002270 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002271 Cytochrome P450; Region: p450; cl12078 1232724002272 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1232724002273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724002274 DNA-binding site [nucleotide binding]; DNA binding site 1232724002275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724002276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724002277 homodimer interface [polypeptide binding]; other site 1232724002278 catalytic residue [active] 1232724002279 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724002280 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1232724002281 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1232724002282 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724002283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724002284 S-adenosylmethionine binding site [chemical binding]; other site 1232724002285 short chain dehydrogenase; Provisional; Region: PRK07890 1232724002286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724002287 NAD(P) binding site [chemical binding]; other site 1232724002288 active site 1232724002289 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1232724002290 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1232724002291 B12 binding site [chemical binding]; other site 1232724002292 cobalt ligand [ion binding]; other site 1232724002293 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1232724002294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724002295 putative CoA-transferase; Provisional; Region: PRK11430 1232724002296 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724002297 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724002298 SnoaL-like domain; Region: SnoaL_3; pfam13474 1232724002299 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724002300 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 1232724002301 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724002302 catalytic loop [active] 1232724002303 iron binding site [ion binding]; other site 1232724002304 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1232724002305 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724002306 acyl-activating enzyme (AAE) consensus motif; other site 1232724002307 AMP binding site [chemical binding]; other site 1232724002308 active site 1232724002309 CoA binding site [chemical binding]; other site 1232724002310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002311 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002314 active site 1232724002315 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724002316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002317 substrate binding site [chemical binding]; other site 1232724002318 oxyanion hole (OAH) forming residues; other site 1232724002319 trimer interface [polypeptide binding]; other site 1232724002320 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1232724002321 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1232724002322 putative acyltransferase; Provisional; Region: PRK05790 1232724002323 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724002324 dimer interface [polypeptide binding]; other site 1232724002325 active site 1232724002326 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1232724002327 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1232724002328 Walker A; other site 1232724002329 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1232724002330 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1232724002331 TPP-binding site [chemical binding]; other site 1232724002332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724002334 active site 1232724002335 phosphorylation site [posttranslational modification] 1232724002336 intermolecular recognition site; other site 1232724002337 dimerization interface [polypeptide binding]; other site 1232724002338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724002339 DNA binding residues [nucleotide binding] 1232724002340 dimerization interface [polypeptide binding]; other site 1232724002341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232724002342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724002343 ATP binding site [chemical binding]; other site 1232724002344 Mg2+ binding site [ion binding]; other site 1232724002345 G-X-G motif; other site 1232724002346 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1232724002347 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1232724002348 conserved cys residue [active] 1232724002349 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1232724002350 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1232724002351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232724002352 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1232724002353 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724002354 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724002355 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1232724002356 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724002357 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 1232724002358 active site 1232724002359 metal binding site [ion binding]; metal-binding site 1232724002360 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1232724002361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724002362 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1232724002363 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232724002364 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724002365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724002366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724002367 NAD(P) binding site [chemical binding]; other site 1232724002368 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1232724002369 active site 1232724002370 Putative cyclase; Region: Cyclase; pfam04199 1232724002371 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724002372 TAP-like protein; Region: Abhydrolase_4; pfam08386 1232724002373 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1232724002374 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1232724002375 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1232724002376 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1232724002377 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1232724002378 short chain dehydrogenase; Provisional; Region: PRK06500 1232724002379 classical (c) SDRs; Region: SDR_c; cd05233 1232724002380 NAD(P) binding site [chemical binding]; other site 1232724002381 active site 1232724002382 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1232724002383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724002384 NAD(P) binding site [chemical binding]; other site 1232724002385 active site 1232724002386 AAA ATPase domain; Region: AAA_16; pfam13191 1232724002387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724002388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724002389 DNA binding residues [nucleotide binding] 1232724002390 dimerization interface [polypeptide binding]; other site 1232724002391 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1232724002392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724002393 NAD(P) binding site [chemical binding]; other site 1232724002394 active site 1232724002395 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1232724002396 active site 1232724002397 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1232724002398 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1232724002399 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1232724002400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724002401 putative ADP-binding pocket [chemical binding]; other site 1232724002402 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232724002403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002405 Cytochrome P450; Region: p450; cl12078 1232724002406 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002407 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724002408 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232724002409 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232724002410 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1232724002411 active site 1232724002412 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232724002413 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232724002414 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1232724002415 active site 1232724002416 enoyl-CoA hydratase; Provisional; Region: PRK12478 1232724002417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002418 substrate binding site [chemical binding]; other site 1232724002419 oxyanion hole (OAH) forming residues; other site 1232724002420 trimer interface [polypeptide binding]; other site 1232724002421 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724002422 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724002423 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724002424 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724002425 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1232724002426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724002427 NAD(P) binding site [chemical binding]; other site 1232724002428 active site 1232724002429 short chain dehydrogenase; Provisional; Region: PRK05876 1232724002430 classical (c) SDRs; Region: SDR_c; cd05233 1232724002431 NAD(P) binding site [chemical binding]; other site 1232724002432 active site 1232724002433 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724002434 classical (c) SDRs; Region: SDR_c; cd05233 1232724002435 NAD(P) binding site [chemical binding]; other site 1232724002436 active site 1232724002437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002441 active site 1232724002442 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002443 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002444 active site 1232724002445 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002446 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002447 active site 1232724002448 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724002449 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1232724002450 Amidohydrolase; Region: Amidohydro_4; pfam13147 1232724002451 active site 1232724002452 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724002453 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724002454 [2Fe-2S] cluster binding site [ion binding]; other site 1232724002455 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1232724002456 alpha subunit interface [polypeptide binding]; other site 1232724002457 active site 1232724002458 substrate binding site [chemical binding]; other site 1232724002459 Fe binding site [ion binding]; other site 1232724002460 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724002461 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724002462 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724002463 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002464 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002465 active site 1232724002466 enoyl-CoA hydratase; Provisional; Region: PRK06688 1232724002467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002468 substrate binding site [chemical binding]; other site 1232724002469 oxyanion hole (OAH) forming residues; other site 1232724002470 trimer interface [polypeptide binding]; other site 1232724002471 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1232724002472 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724002473 dimer interface [polypeptide binding]; other site 1232724002474 active site 1232724002475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002476 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002477 Cytochrome P450; Region: p450; cl12078 1232724002478 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1232724002479 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1232724002480 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1232724002481 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1232724002482 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002483 Cytochrome P450; Region: p450; cl12078 1232724002484 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1232724002485 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1232724002486 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1232724002487 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1232724002488 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724002489 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724002490 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724002491 lipid-transfer protein; Provisional; Region: PRK07855 1232724002492 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724002493 active site 1232724002494 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724002495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724002496 NAD(P) binding site [chemical binding]; other site 1232724002497 active site 1232724002498 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1232724002499 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724002500 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724002501 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002502 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002503 active site 1232724002504 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1232724002505 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1232724002506 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724002507 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1232724002508 iron-sulfur cluster [ion binding]; other site 1232724002509 [2Fe-2S] cluster binding site [ion binding]; other site 1232724002510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724002511 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724002512 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1232724002513 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1232724002514 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1232724002515 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1232724002516 FMN binding site [chemical binding]; other site 1232724002517 dimer interface [polypeptide binding]; other site 1232724002518 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1232724002519 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724002520 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002521 active site 1232724002522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002523 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002524 active site 1232724002525 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002526 Cytochrome P450; Region: p450; cl12078 1232724002527 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1232724002528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724002529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724002530 NAD(P) binding site [chemical binding]; other site 1232724002531 active site 1232724002532 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1232724002533 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1232724002534 NAD binding site [chemical binding]; other site 1232724002535 catalytic residues [active] 1232724002536 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724002537 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724002538 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724002539 Permease; Region: Permease; pfam02405 1232724002540 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724002541 Permease; Region: Permease; pfam02405 1232724002542 mce related protein; Region: MCE; pfam02470 1232724002543 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724002544 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724002545 mce related protein; Region: MCE; pfam02470 1232724002546 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724002547 mce related protein; Region: MCE; pfam02470 1232724002548 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724002549 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724002550 mce related protein; Region: MCE; pfam02470 1232724002551 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724002552 mce related protein; Region: MCE; pfam02470 1232724002553 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724002554 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724002555 mce related protein; Region: MCE; pfam02470 1232724002556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002558 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1232724002559 Subunit I/III interface [polypeptide binding]; other site 1232724002560 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002561 Cytochrome P450; Region: p450; cl12078 1232724002562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002564 enoyl-CoA hydratase; Provisional; Region: PRK06688 1232724002565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002566 substrate binding site [chemical binding]; other site 1232724002567 oxyanion hole (OAH) forming residues; other site 1232724002568 trimer interface [polypeptide binding]; other site 1232724002569 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1232724002570 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724002571 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1232724002572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724002573 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1232724002574 acyl-activating enzyme (AAE) consensus motif; other site 1232724002575 acyl-activating enzyme (AAE) consensus motif; other site 1232724002576 putative AMP binding site [chemical binding]; other site 1232724002577 putative active site [active] 1232724002578 putative CoA binding site [chemical binding]; other site 1232724002579 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1232724002580 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1232724002581 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1232724002582 dimer interface [polypeptide binding]; other site 1232724002583 PYR/PP interface [polypeptide binding]; other site 1232724002584 TPP binding site [chemical binding]; other site 1232724002585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724002586 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1232724002587 TPP-binding site [chemical binding]; other site 1232724002588 dimer interface [polypeptide binding]; other site 1232724002589 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1232724002590 putative hydrophobic ligand binding site [chemical binding]; other site 1232724002591 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724002592 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724002593 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1232724002594 putative hydrophobic ligand binding site [chemical binding]; other site 1232724002595 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1232724002596 putative hydrophobic ligand binding site [chemical binding]; other site 1232724002597 aminotransferase; Validated; Region: PRK07777 1232724002598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724002599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724002600 homodimer interface [polypeptide binding]; other site 1232724002601 catalytic residue [active] 1232724002602 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1232724002603 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724002604 dimer interface [polypeptide binding]; other site 1232724002605 active site 1232724002606 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724002607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002608 substrate binding site [chemical binding]; other site 1232724002609 oxyanion hole (OAH) forming residues; other site 1232724002610 trimer interface [polypeptide binding]; other site 1232724002611 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1232724002612 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1232724002613 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1232724002614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724002615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724002616 S-adenosylmethionine binding site [chemical binding]; other site 1232724002617 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1232724002618 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1232724002619 hypothetical protein; Provisional; Region: PRK07588 1232724002620 hypothetical protein; Provisional; Region: PRK07236 1232724002621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724002622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724002623 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724002624 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1232724002625 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1232724002626 Cupin; Region: Cupin_6; pfam12852 1232724002627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232724002628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724002629 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1232724002630 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724002631 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724002632 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1232724002633 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724002634 active site 1232724002635 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1232724002636 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232724002637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1232724002638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724002639 ATP binding site [chemical binding]; other site 1232724002640 putative Mg++ binding site [ion binding]; other site 1232724002641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724002642 nucleotide binding region [chemical binding]; other site 1232724002643 ATP-binding site [chemical binding]; other site 1232724002644 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1232724002645 WYL domain; Region: WYL; pfam13280 1232724002646 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1232724002647 trimer interface [polypeptide binding]; other site 1232724002648 dimer interface [polypeptide binding]; other site 1232724002649 putative active site [active] 1232724002650 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1232724002651 MPT binding site; other site 1232724002652 trimer interface [polypeptide binding]; other site 1232724002653 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1232724002654 MoaE homodimer interface [polypeptide binding]; other site 1232724002655 MoaD interaction [polypeptide binding]; other site 1232724002656 active site residues [active] 1232724002657 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1232724002658 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1232724002659 MoaE interaction surface [polypeptide binding]; other site 1232724002660 MoeB interaction surface [polypeptide binding]; other site 1232724002661 thiocarboxylated glycine; other site 1232724002662 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1232724002663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724002664 FeS/SAM binding site; other site 1232724002665 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1232724002666 hypothetical protein; Provisional; Region: PRK11770 1232724002667 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1232724002668 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1232724002669 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232724002670 DNA-binding site [nucleotide binding]; DNA binding site 1232724002671 RNA-binding motif; other site 1232724002672 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232724002673 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002674 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002675 active site 1232724002676 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1232724002677 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232724002678 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1232724002679 putative dimer interface [polypeptide binding]; other site 1232724002680 N-terminal domain interface [polypeptide binding]; other site 1232724002681 putative substrate binding pocket (H-site) [chemical binding]; other site 1232724002682 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1232724002683 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1232724002684 H+ Antiporter protein; Region: 2A0121; TIGR00900 1232724002685 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1232724002686 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724002687 hydrophobic ligand binding site; other site 1232724002688 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724002689 MarR family; Region: MarR; pfam01047 1232724002690 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232724002691 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232724002692 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1232724002693 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1232724002694 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724002695 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724002696 catalytic residue [active] 1232724002697 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1232724002698 Ferredoxin [Energy production and conversion]; Region: COG1146 1232724002699 4Fe-4S binding domain; Region: Fer4; pfam00037 1232724002700 ferredoxin-NADP+ reductase; Region: PLN02852 1232724002701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724002702 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1232724002703 putative dimer interface [polypeptide binding]; other site 1232724002704 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724002705 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1232724002706 dimer interface [polypeptide binding]; other site 1232724002707 Citrate synthase; Region: Citrate_synt; pfam00285 1232724002708 active site 1232724002709 citrylCoA binding site [chemical binding]; other site 1232724002710 oxalacetate/citrate binding site [chemical binding]; other site 1232724002711 coenzyme A binding site [chemical binding]; other site 1232724002712 catalytic triad [active] 1232724002713 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1232724002714 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1232724002715 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1232724002716 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1232724002717 active site 1232724002718 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1232724002719 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1232724002720 dimer interface [polypeptide binding]; other site 1232724002721 active site 1232724002722 citrylCoA binding site [chemical binding]; other site 1232724002723 NADH binding [chemical binding]; other site 1232724002724 cationic pore residues; other site 1232724002725 oxalacetate/citrate binding site [chemical binding]; other site 1232724002726 coenzyme A binding site [chemical binding]; other site 1232724002727 catalytic triad [active] 1232724002728 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724002729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724002730 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1232724002731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724002732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724002733 dimer interface [polypeptide binding]; other site 1232724002734 phosphorylation site [posttranslational modification] 1232724002735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724002736 ATP binding site [chemical binding]; other site 1232724002737 Mg2+ binding site [ion binding]; other site 1232724002738 G-X-G motif; other site 1232724002739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724002740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724002741 active site 1232724002742 phosphorylation site [posttranslational modification] 1232724002743 intermolecular recognition site; other site 1232724002744 dimerization interface [polypeptide binding]; other site 1232724002745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724002746 DNA binding site [nucleotide binding] 1232724002747 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232724002748 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1232724002749 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724002750 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724002751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002752 substrate binding site [chemical binding]; other site 1232724002753 oxyanion hole (OAH) forming residues; other site 1232724002754 trimer interface [polypeptide binding]; other site 1232724002755 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232724002756 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1232724002757 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724002758 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724002759 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1232724002760 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1232724002761 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724002762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724002763 motif II; other site 1232724002764 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1232724002765 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724002766 hydrophobic ligand binding site; other site 1232724002767 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1232724002768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724002769 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1232724002770 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724002771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724002772 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1232724002773 active site 1232724002774 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1232724002775 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1232724002776 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1232724002777 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724002778 active site 1232724002779 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1232724002780 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724002781 PPE family; Region: PPE; pfam00823 1232724002782 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724002783 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724002784 PPE family; Region: PPE; pfam00823 1232724002785 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1232724002786 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724002787 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1232724002788 dimerization interface [polypeptide binding]; other site 1232724002789 putative catalytic residue [active] 1232724002790 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1232724002791 manganese transport protein MntH; Reviewed; Region: PRK00701 1232724002792 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1232724002793 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724002794 short chain dehydrogenase; Provisional; Region: PRK07814 1232724002795 classical (c) SDRs; Region: SDR_c; cd05233 1232724002796 NAD(P) binding site [chemical binding]; other site 1232724002797 active site 1232724002798 PBP superfamily domain; Region: PBP_like_2; cl17296 1232724002799 PBP superfamily domain; Region: PBP_like_2; cl17296 1232724002800 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1232724002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724002802 dimer interface [polypeptide binding]; other site 1232724002803 conserved gate region; other site 1232724002804 putative PBP binding loops; other site 1232724002805 ABC-ATPase subunit interface; other site 1232724002806 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1232724002807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724002808 dimer interface [polypeptide binding]; other site 1232724002809 conserved gate region; other site 1232724002810 putative PBP binding loops; other site 1232724002811 ABC-ATPase subunit interface; other site 1232724002812 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1232724002813 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1232724002814 putative DNA binding site [nucleotide binding]; other site 1232724002815 putative homodimer interface [polypeptide binding]; other site 1232724002816 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232724002817 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1232724002818 putative substrate binding site [chemical binding]; other site 1232724002819 putative ATP binding site [chemical binding]; other site 1232724002820 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1232724002821 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1232724002822 nucleotide binding site [chemical binding]; other site 1232724002823 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1232724002824 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1232724002825 active site 1232724002826 DNA binding site [nucleotide binding] 1232724002827 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1232724002828 DNA binding site [nucleotide binding] 1232724002829 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1232724002830 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1232724002831 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724002832 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724002833 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724002834 enoyl-CoA hydratase; Provisional; Region: PRK08260 1232724002835 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002836 substrate binding site [chemical binding]; other site 1232724002837 oxyanion hole (OAH) forming residues; other site 1232724002838 trimer interface [polypeptide binding]; other site 1232724002839 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724002840 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724002841 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724002842 anti sigma factor interaction site; other site 1232724002843 regulatory phosphorylation site [posttranslational modification]; other site 1232724002844 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724002845 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1232724002846 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1232724002847 active site 1232724002848 SAM binding site [chemical binding]; other site 1232724002849 homodimer interface [polypeptide binding]; other site 1232724002850 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1232724002851 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1232724002852 putative DNA binding site [nucleotide binding]; other site 1232724002853 catalytic residue [active] 1232724002854 putative H2TH interface [polypeptide binding]; other site 1232724002855 putative catalytic residues [active] 1232724002856 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232724002857 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232724002858 short chain dehydrogenase; Provisional; Region: PRK08251 1232724002859 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1232724002860 putative NAD(P) binding site [chemical binding]; other site 1232724002861 active site 1232724002862 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1232724002863 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1232724002864 active site 1232724002865 dimer interface [polypeptide binding]; other site 1232724002866 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1232724002867 dimer interface [polypeptide binding]; other site 1232724002868 active site 1232724002869 Chorismate mutase type II; Region: CM_2; cl00693 1232724002870 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1232724002871 Part of AAA domain; Region: AAA_19; pfam13245 1232724002872 Family description; Region: UvrD_C_2; pfam13538 1232724002873 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1232724002874 Peptidase family M23; Region: Peptidase_M23; pfam01551 1232724002875 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1232724002876 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1232724002877 CoA-ligase; Region: Ligase_CoA; pfam00549 1232724002878 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1232724002879 CoA binding domain; Region: CoA_binding; smart00881 1232724002880 CoA-ligase; Region: Ligase_CoA; pfam00549 1232724002881 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1232724002882 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724002883 Omptin family; Region: Omptin; cl01886 1232724002884 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724002885 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724002886 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1232724002887 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1232724002888 active site 1232724002889 substrate binding site [chemical binding]; other site 1232724002890 cosubstrate binding site; other site 1232724002891 catalytic site [active] 1232724002892 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1232724002893 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1232724002894 purine monophosphate binding site [chemical binding]; other site 1232724002895 dimer interface [polypeptide binding]; other site 1232724002896 putative catalytic residues [active] 1232724002897 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1232724002898 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1232724002899 LGFP repeat; Region: LGFP; pfam08310 1232724002900 LGFP repeat; Region: LGFP; pfam08310 1232724002901 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1232724002902 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1232724002903 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1232724002904 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1232724002905 metal ion-dependent adhesion site (MIDAS); other site 1232724002906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724002907 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724002908 active site 1232724002909 catalytic tetrad [active] 1232724002910 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1232724002911 enoyl-CoA hydratase; Provisional; Region: PRK07827 1232724002912 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724002913 substrate binding site [chemical binding]; other site 1232724002914 oxyanion hole (OAH) forming residues; other site 1232724002915 trimer interface [polypeptide binding]; other site 1232724002916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002917 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724002918 active site 1232724002919 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1232724002920 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232724002921 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724002922 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232724002923 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232724002924 carboxyltransferase (CT) interaction site; other site 1232724002925 biotinylation site [posttranslational modification]; other site 1232724002926 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232724002927 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724002928 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724002929 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724002930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724002931 active site 1232724002932 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1232724002933 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1232724002934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724002935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724002936 active site 1232724002937 phosphorylation site [posttranslational modification] 1232724002938 intermolecular recognition site; other site 1232724002939 dimerization interface [polypeptide binding]; other site 1232724002940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724002941 DNA binding site [nucleotide binding] 1232724002942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724002943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232724002944 dimerization interface [polypeptide binding]; other site 1232724002945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724002946 dimer interface [polypeptide binding]; other site 1232724002947 phosphorylation site [posttranslational modification] 1232724002948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724002949 ATP binding site [chemical binding]; other site 1232724002950 Mg2+ binding site [ion binding]; other site 1232724002951 G-X-G motif; other site 1232724002952 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1232724002953 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232724002954 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1232724002955 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1232724002956 MPT binding site; other site 1232724002957 trimer interface [polypeptide binding]; other site 1232724002958 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1232724002959 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1232724002960 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1232724002961 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1232724002962 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1232724002963 active site 1232724002964 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1232724002965 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1232724002966 dimer interface [polypeptide binding]; other site 1232724002967 putative functional site; other site 1232724002968 putative MPT binding site; other site 1232724002969 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1232724002970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232724002971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724002972 MarR family; Region: MarR_2; pfam12802 1232724002973 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1232724002974 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1232724002975 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724002976 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724002977 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1232724002978 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232724002979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724002980 DNA-binding site [nucleotide binding]; DNA binding site 1232724002981 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1232724002982 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724002983 Cytochrome P450; Region: p450; cl12078 1232724002984 Predicted acyl esterases [General function prediction only]; Region: COG2936 1232724002985 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1232724002986 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1232724002987 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1232724002988 metal binding site [ion binding]; metal-binding site 1232724002989 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1232724002990 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1232724002991 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1232724002992 dimer interface [polypeptide binding]; other site 1232724002993 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1232724002994 active site 1232724002995 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1232724002996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724002997 active site 1232724002998 motif I; other site 1232724002999 motif II; other site 1232724003000 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232724003001 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232724003002 ligand binding site [chemical binding]; other site 1232724003003 flexible hinge region; other site 1232724003004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1232724003005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724003006 Coenzyme A binding pocket [chemical binding]; other site 1232724003007 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1232724003008 Amidinotransferase; Region: Amidinotransf; cl12043 1232724003009 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1232724003010 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1232724003011 Predicted methyltransferases [General function prediction only]; Region: COG0313 1232724003012 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1232724003013 putative SAM binding site [chemical binding]; other site 1232724003014 putative homodimer interface [polypeptide binding]; other site 1232724003015 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1232724003016 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1232724003017 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1232724003018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724003019 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1232724003020 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232724003021 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724003022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724003023 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1232724003024 GAF domain; Region: GAF; pfam01590 1232724003025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1232724003026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232724003027 metal binding site [ion binding]; metal-binding site 1232724003028 active site 1232724003029 I-site; other site 1232724003030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1232724003031 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1232724003032 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1232724003033 Chain length determinant protein; Region: Wzz; pfam02706 1232724003034 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1232724003035 O-Antigen ligase; Region: Wzy_C; cl04850 1232724003036 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724003037 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724003038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724003039 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724003040 active site 1232724003041 catalytic tetrad [active] 1232724003042 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1232724003043 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1232724003044 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1232724003045 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1232724003046 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1232724003047 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1232724003048 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1232724003049 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232724003050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724003051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1232724003052 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232724003053 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232724003054 active site 1232724003055 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232724003056 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724003057 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724003058 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1232724003059 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1232724003060 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1232724003061 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1232724003062 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1232724003063 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724003064 PPE family; Region: PPE; pfam00823 1232724003065 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724003066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1232724003071 PAS domain; Region: PAS_9; pfam13426 1232724003072 putative active site [active] 1232724003073 heme pocket [chemical binding]; other site 1232724003074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003075 WHG domain; Region: WHG; pfam13305 1232724003076 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1232724003077 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1232724003078 active site 1232724003079 HIGH motif; other site 1232724003080 KMSKS motif; other site 1232724003081 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1232724003082 tRNA binding surface [nucleotide binding]; other site 1232724003083 anticodon binding site; other site 1232724003084 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1232724003085 active site 1232724003086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1232724003087 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1232724003088 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1232724003089 G5 domain; Region: G5; pfam07501 1232724003090 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1232724003091 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1232724003092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724003093 S-adenosylmethionine binding site [chemical binding]; other site 1232724003094 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1232724003095 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1232724003096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724003097 acyl-activating enzyme (AAE) consensus motif; other site 1232724003098 AMP binding site [chemical binding]; other site 1232724003099 active site 1232724003100 CoA binding site [chemical binding]; other site 1232724003101 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1232724003102 putative active site [active] 1232724003103 catalytic residue [active] 1232724003104 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1232724003105 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1232724003106 5S rRNA interface [nucleotide binding]; other site 1232724003107 CTC domain interface [polypeptide binding]; other site 1232724003108 L16 interface [polypeptide binding]; other site 1232724003109 short chain dehydrogenase; Provisional; Region: PRK06197 1232724003110 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1232724003111 putative NAD(P) binding site [chemical binding]; other site 1232724003112 active site 1232724003113 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724003114 Cytochrome P450; Region: p450; cl12078 1232724003115 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724003116 cyclase homology domain; Region: CHD; cd07302 1232724003117 nucleotidyl binding site; other site 1232724003118 metal binding site [ion binding]; metal-binding site 1232724003119 dimer interface [polypeptide binding]; other site 1232724003120 Predicted ATPase [General function prediction only]; Region: COG3903 1232724003121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724003122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724003123 DNA binding residues [nucleotide binding] 1232724003124 dimerization interface [polypeptide binding]; other site 1232724003125 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1232724003126 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1232724003127 ArsC family; Region: ArsC; pfam03960 1232724003128 catalytic residues [active] 1232724003129 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1232724003130 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1232724003131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232724003132 active site 1232724003133 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1232724003134 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1232724003135 Substrate binding site; other site 1232724003136 Mg++ binding site; other site 1232724003137 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1232724003138 active site 1232724003139 substrate binding site [chemical binding]; other site 1232724003140 CoA binding site [chemical binding]; other site 1232724003141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003143 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1232724003144 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1232724003145 active site 1232724003146 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232724003147 substrate binding site [chemical binding]; other site 1232724003148 catalytic residues [active] 1232724003149 dimer interface [polypeptide binding]; other site 1232724003150 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1232724003151 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1232724003152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724003153 ATP binding site [chemical binding]; other site 1232724003154 putative Mg++ binding site [ion binding]; other site 1232724003155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724003156 nucleotide binding region [chemical binding]; other site 1232724003157 ATP-binding site [chemical binding]; other site 1232724003158 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1232724003159 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1232724003160 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1232724003161 homodimer interface [polypeptide binding]; other site 1232724003162 metal binding site [ion binding]; metal-binding site 1232724003163 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1232724003164 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1232724003165 enolase; Provisional; Region: eno; PRK00077 1232724003166 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1232724003167 dimer interface [polypeptide binding]; other site 1232724003168 metal binding site [ion binding]; metal-binding site 1232724003169 substrate binding pocket [chemical binding]; other site 1232724003170 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1232724003171 Septum formation initiator; Region: DivIC; pfam04977 1232724003172 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1232724003173 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1232724003174 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1232724003175 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1232724003176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724003177 active site 1232724003178 phosphorylation site [posttranslational modification] 1232724003179 intermolecular recognition site; other site 1232724003180 dimerization interface [polypeptide binding]; other site 1232724003181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724003182 DNA binding site [nucleotide binding] 1232724003183 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1232724003184 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1232724003185 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1232724003186 Ligand Binding Site [chemical binding]; other site 1232724003187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724003188 dimer interface [polypeptide binding]; other site 1232724003189 phosphorylation site [posttranslational modification] 1232724003190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724003191 ATP binding site [chemical binding]; other site 1232724003192 Mg2+ binding site [ion binding]; other site 1232724003193 G-X-G motif; other site 1232724003194 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1232724003195 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1232724003196 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1232724003197 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724003198 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1232724003199 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1232724003200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724003201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724003202 dimer interface [polypeptide binding]; other site 1232724003203 phosphorylation site [posttranslational modification] 1232724003204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724003205 ATP binding site [chemical binding]; other site 1232724003206 Mg2+ binding site [ion binding]; other site 1232724003207 G-X-G motif; other site 1232724003208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724003209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724003210 active site 1232724003211 phosphorylation site [posttranslational modification] 1232724003212 intermolecular recognition site; other site 1232724003213 dimerization interface [polypeptide binding]; other site 1232724003214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724003215 DNA binding site [nucleotide binding] 1232724003216 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1232724003217 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1232724003218 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724003219 PPE family; Region: PPE; pfam00823 1232724003220 PE family; Region: PE; pfam00934 1232724003221 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724003222 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724003223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724003224 S-adenosylmethionine binding site [chemical binding]; other site 1232724003225 Domain of unknown function (DUF427); Region: DUF427; cl00998 1232724003226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1232724003227 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1232724003228 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1232724003229 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1232724003230 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1232724003231 dimer interface [polypeptide binding]; other site 1232724003232 acyl-activating enzyme (AAE) consensus motif; other site 1232724003233 putative active site [active] 1232724003234 AMP binding site [chemical binding]; other site 1232724003235 putative CoA binding site [chemical binding]; other site 1232724003236 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1232724003237 putative hydrophobic ligand binding site [chemical binding]; other site 1232724003238 protein interface [polypeptide binding]; other site 1232724003239 gate; other site 1232724003240 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1232724003241 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1232724003242 putative active site [active] 1232724003243 putative dimer interface [polypeptide binding]; other site 1232724003244 Patatin-like phospholipase; Region: Patatin; pfam01734 1232724003245 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1232724003246 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1232724003247 active site 1232724003248 nucleophile elbow; other site 1232724003249 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1232724003250 Rhodanese Homology Domain; Region: RHOD; smart00450 1232724003251 active site residue [active] 1232724003252 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1232724003253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1232724003254 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1232724003255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003257 Predicted membrane protein [Function unknown]; Region: COG4425 1232724003258 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1232724003259 enoyl-CoA hydratase; Provisional; Region: PRK05862 1232724003260 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724003261 substrate binding site [chemical binding]; other site 1232724003262 oxyanion hole (OAH) forming residues; other site 1232724003263 trimer interface [polypeptide binding]; other site 1232724003264 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1232724003265 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724003266 substrate binding site [chemical binding]; other site 1232724003267 oxyanion hole (OAH) forming residues; other site 1232724003268 trimer interface [polypeptide binding]; other site 1232724003269 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1232724003270 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1232724003271 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1232724003272 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724003273 dimer interface [polypeptide binding]; other site 1232724003274 active site 1232724003275 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1232724003276 active site 1232724003277 catalytic triad [active] 1232724003278 oxyanion hole [active] 1232724003279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724003280 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724003281 substrate binding pocket [chemical binding]; other site 1232724003282 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1232724003283 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232724003284 dimer interface [polypeptide binding]; other site 1232724003285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724003286 catalytic residue [active] 1232724003287 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1232724003288 RDD family; Region: RDD; pfam06271 1232724003289 cystathionine gamma-synthase; Provisional; Region: PRK07811 1232724003290 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1232724003291 homodimer interface [polypeptide binding]; other site 1232724003292 substrate-cofactor binding pocket; other site 1232724003293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724003294 catalytic residue [active] 1232724003295 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1232724003296 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1232724003297 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1232724003298 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1232724003299 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1232724003300 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1232724003301 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1232724003302 catalytic residues [active] 1232724003303 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724003304 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1232724003305 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1232724003306 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1232724003307 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1232724003308 catalytic residue [active] 1232724003309 putative FPP diphosphate binding site; other site 1232724003310 putative FPP binding hydrophobic cleft; other site 1232724003311 dimer interface [polypeptide binding]; other site 1232724003312 putative IPP diphosphate binding site; other site 1232724003313 pantothenate kinase; Provisional; Region: PRK05439 1232724003314 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1232724003315 ATP-binding site [chemical binding]; other site 1232724003316 CoA-binding site [chemical binding]; other site 1232724003317 Mg2+-binding site [ion binding]; other site 1232724003318 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1232724003319 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1232724003320 dimer interface [polypeptide binding]; other site 1232724003321 active site 1232724003322 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1232724003323 folate binding site [chemical binding]; other site 1232724003324 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1232724003325 dinuclear metal binding motif [ion binding]; other site 1232724003326 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1232724003327 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1232724003328 putative active site [active] 1232724003329 PhoH-like protein; Region: PhoH; pfam02562 1232724003330 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1232724003331 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1232724003332 NodB motif; other site 1232724003333 active site 1232724003334 catalytic site [active] 1232724003335 metal binding site [ion binding]; metal-binding site 1232724003336 HAMP domain; Region: HAMP; pfam00672 1232724003337 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1232724003338 cyclase homology domain; Region: CHD; cd07302 1232724003339 nucleotidyl binding site; other site 1232724003340 metal binding site [ion binding]; metal-binding site 1232724003341 dimer interface [polypeptide binding]; other site 1232724003342 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1232724003343 Class II fumarases; Region: Fumarase_classII; cd01362 1232724003344 active site 1232724003345 tetramer interface [polypeptide binding]; other site 1232724003346 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1232724003347 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1232724003348 putative active site [active] 1232724003349 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1232724003350 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1232724003351 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1232724003352 homodimer interface [polypeptide binding]; other site 1232724003353 active site 1232724003354 TDP-binding site; other site 1232724003355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724003356 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724003357 acyl-activating enzyme (AAE) consensus motif; other site 1232724003358 AMP binding site [chemical binding]; other site 1232724003359 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724003360 Condensation domain; Region: Condensation; pfam00668 1232724003361 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724003362 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1232724003363 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724003364 substrate binding pocket [chemical binding]; other site 1232724003365 catalytic triad [active] 1232724003366 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1232724003367 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1232724003368 putative NAD(P) binding site [chemical binding]; other site 1232724003369 active site 1232724003370 putative substrate binding site [chemical binding]; other site 1232724003371 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1232724003372 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1232724003373 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1232724003374 generic binding surface II; other site 1232724003375 generic binding surface I; other site 1232724003376 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1232724003377 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1232724003378 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1232724003379 GTP-binding protein YchF; Reviewed; Region: PRK09601 1232724003380 YchF GTPase; Region: YchF; cd01900 1232724003381 G1 box; other site 1232724003382 GTP/Mg2+ binding site [chemical binding]; other site 1232724003383 Switch I region; other site 1232724003384 G2 box; other site 1232724003385 Switch II region; other site 1232724003386 G3 box; other site 1232724003387 G4 box; other site 1232724003388 G5 box; other site 1232724003389 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1232724003390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724003391 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1232724003392 putative active site [active] 1232724003393 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1232724003394 putative dimer interface [polypeptide binding]; other site 1232724003395 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724003396 ligand binding site [chemical binding]; other site 1232724003397 Zn binding site [ion binding]; other site 1232724003398 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724003399 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1232724003400 active site 1232724003401 metal binding site [ion binding]; metal-binding site 1232724003402 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1232724003403 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724003404 cyclase homology domain; Region: CHD; cd07302 1232724003405 nucleotidyl binding site; other site 1232724003406 metal binding site [ion binding]; metal-binding site 1232724003407 dimer interface [polypeptide binding]; other site 1232724003408 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1232724003409 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1232724003410 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1232724003411 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1232724003412 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1232724003413 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724003414 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724003415 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1232724003416 dimer interface [polypeptide binding]; other site 1232724003417 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724003418 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724003419 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1232724003420 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1232724003421 Predicted membrane protein [Function unknown]; Region: COG2259 1232724003422 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1232724003423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724003424 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1232724003425 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1232724003426 TrkA-C domain; Region: TrkA_C; pfam02080 1232724003427 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1232724003428 TrkA-N domain; Region: TrkA_N; pfam02254 1232724003429 TrkA-C domain; Region: TrkA_C; pfam02080 1232724003430 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1232724003431 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1232724003432 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1232724003433 THF binding site; other site 1232724003434 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1232724003435 substrate binding site [chemical binding]; other site 1232724003436 THF binding site; other site 1232724003437 zinc-binding site [ion binding]; other site 1232724003438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003439 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232724003440 NAD(P) binding site [chemical binding]; other site 1232724003441 active site 1232724003442 short chain dehydrogenase; Provisional; Region: PRK12829 1232724003443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003444 NAD(P) binding site [chemical binding]; other site 1232724003445 active site 1232724003446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003450 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1232724003451 FMN binding site [chemical binding]; other site 1232724003452 dimer interface [polypeptide binding]; other site 1232724003453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724003454 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724003455 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724003456 active site 1232724003457 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724003458 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1232724003459 active site 1232724003460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003461 short chain dehydrogenase; Provisional; Region: PRK07791 1232724003462 NAD(P) binding site [chemical binding]; other site 1232724003463 active site 1232724003464 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1232724003465 metal ion-dependent adhesion site (MIDAS); other site 1232724003466 MoxR-like ATPases [General function prediction only]; Region: COG0714 1232724003467 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1232724003468 Walker A motif; other site 1232724003469 ATP binding site [chemical binding]; other site 1232724003470 Walker B motif; other site 1232724003471 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1232724003472 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1232724003473 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1232724003474 ligand binding site [chemical binding]; other site 1232724003475 short chain dehydrogenase; Provisional; Region: PRK06914 1232724003476 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1232724003477 NADP binding site [chemical binding]; other site 1232724003478 active site 1232724003479 steroid binding site; other site 1232724003480 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724003481 Cytochrome P450; Region: p450; cl12078 1232724003482 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1232724003483 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1232724003484 NAD binding site [chemical binding]; other site 1232724003485 catalytic residues [active] 1232724003486 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724003487 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724003488 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724003489 Cytochrome P450; Region: p450; cl12078 1232724003490 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1232724003491 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724003492 putative acyl-acceptor binding pocket; other site 1232724003493 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724003494 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724003495 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1232724003496 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1232724003497 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724003498 dimer interface [polypeptide binding]; other site 1232724003499 active site 1232724003500 enoyl-CoA hydratase; Provisional; Region: PRK08252 1232724003501 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724003502 substrate binding site [chemical binding]; other site 1232724003503 oxyanion hole (OAH) forming residues; other site 1232724003504 trimer interface [polypeptide binding]; other site 1232724003505 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724003506 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1232724003507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1232724003508 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1232724003509 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1232724003510 malonyl-CoA binding site [chemical binding]; other site 1232724003511 dimer interface [polypeptide binding]; other site 1232724003512 active site 1232724003513 product binding site; other site 1232724003514 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1232724003515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003516 NAD(P) binding site [chemical binding]; other site 1232724003517 active site 1232724003518 CAAX protease self-immunity; Region: Abi; pfam02517 1232724003519 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1232724003520 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1232724003521 putative NAD(P) binding site [chemical binding]; other site 1232724003522 putative active site [active] 1232724003523 enoyl-CoA hydratase; Provisional; Region: PRK06688 1232724003524 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724003525 substrate binding site [chemical binding]; other site 1232724003526 oxyanion hole (OAH) forming residues; other site 1232724003527 trimer interface [polypeptide binding]; other site 1232724003528 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724003529 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724003530 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1232724003531 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1232724003532 NAD binding site [chemical binding]; other site 1232724003533 homodimer interface [polypeptide binding]; other site 1232724003534 homotetramer interface [polypeptide binding]; other site 1232724003535 active site 1232724003536 MMPL family; Region: MMPL; pfam03176 1232724003537 MMPL family; Region: MMPL; pfam03176 1232724003538 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232724003539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724003540 S-adenosylmethionine binding site [chemical binding]; other site 1232724003541 NAD-dependent deacetylase; Provisional; Region: PRK00481 1232724003542 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1232724003543 NAD+ binding site [chemical binding]; other site 1232724003544 substrate binding site [chemical binding]; other site 1232724003545 Zn binding site [ion binding]; other site 1232724003546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724003547 DNA-binding site [nucleotide binding]; DNA binding site 1232724003548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1232724003549 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1232724003550 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724003551 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1232724003552 minor groove reading motif; other site 1232724003553 helix-hairpin-helix signature motif; other site 1232724003554 mannosyltransferase; Provisional; Region: pimE; PRK13375 1232724003555 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232724003556 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1232724003557 aromatic arch; other site 1232724003558 DCoH dimer interaction site [polypeptide binding]; other site 1232724003559 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1232724003560 DCoH tetramer interaction site [polypeptide binding]; other site 1232724003561 substrate binding site [chemical binding]; other site 1232724003562 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1232724003563 active site 1232724003564 8-oxo-dGMP binding site [chemical binding]; other site 1232724003565 nudix motif; other site 1232724003566 metal binding site [ion binding]; metal-binding site 1232724003567 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1232724003568 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1232724003569 [4Fe-4S] binding site [ion binding]; other site 1232724003570 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724003571 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724003572 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724003573 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1232724003574 molybdopterin cofactor binding site; other site 1232724003575 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1232724003576 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1232724003577 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1232724003578 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1232724003579 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1232724003580 G1 box; other site 1232724003581 putative GEF interaction site [polypeptide binding]; other site 1232724003582 GTP/Mg2+ binding site [chemical binding]; other site 1232724003583 Switch I region; other site 1232724003584 G2 box; other site 1232724003585 G3 box; other site 1232724003586 Switch II region; other site 1232724003587 G4 box; other site 1232724003588 G5 box; other site 1232724003589 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1232724003590 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1232724003591 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1232724003592 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1232724003593 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1232724003594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003596 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1232724003597 FO synthase; Reviewed; Region: fbiC; PRK09234 1232724003598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724003599 FeS/SAM binding site; other site 1232724003600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724003601 FeS/SAM binding site; other site 1232724003602 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1232724003603 4Fe-4S binding domain; Region: Fer4; pfam00037 1232724003604 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1232724003605 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724003606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724003607 homodimer interface [polypeptide binding]; other site 1232724003608 catalytic residue [active] 1232724003609 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232724003610 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1232724003611 generic binding surface II; other site 1232724003612 ssDNA binding site; other site 1232724003613 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232724003614 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724003615 active site 1232724003616 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724003617 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1232724003618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003619 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1232724003620 Enoylreductase; Region: PKS_ER; smart00829 1232724003621 NAD(P) binding site [chemical binding]; other site 1232724003622 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1232724003623 KR domain; Region: KR; pfam08659 1232724003624 putative NADP binding site [chemical binding]; other site 1232724003625 active site 1232724003626 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724003627 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724003628 PPE family; Region: PPE; pfam00823 1232724003629 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724003630 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724003631 PPE family; Region: PPE; pfam00823 1232724003632 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724003633 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1232724003634 ligand-binding site [chemical binding]; other site 1232724003635 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1232724003636 ATP-sulfurylase; Region: ATPS; cd00517 1232724003637 active site 1232724003638 HXXH motif; other site 1232724003639 flexible loop; other site 1232724003640 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232724003641 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1232724003642 acyl-CoA synthetase; Validated; Region: PRK05850 1232724003643 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1232724003644 acyl-activating enzyme (AAE) consensus motif; other site 1232724003645 active site 1232724003646 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724003647 PPE family; Region: PPE; pfam00823 1232724003648 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1232724003649 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1232724003650 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232724003651 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1232724003652 NAD(P) binding site [chemical binding]; other site 1232724003653 catalytic residues [active] 1232724003654 Proline dehydrogenase; Region: Pro_dh; cl03282 1232724003655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003657 lipid-transfer protein; Provisional; Region: PRK07855 1232724003658 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724003659 active site 1232724003660 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1232724003661 putative active site [active] 1232724003662 putative catalytic site [active] 1232724003663 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724003664 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724003665 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724003666 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724003667 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1232724003668 NAD binding site [chemical binding]; other site 1232724003669 catalytic residues [active] 1232724003670 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724003671 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1232724003672 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724003673 acyl-CoA synthetase; Validated; Region: PRK07787 1232724003674 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724003675 acyl-activating enzyme (AAE) consensus motif; other site 1232724003676 AMP binding site [chemical binding]; other site 1232724003677 active site 1232724003678 CoA binding site [chemical binding]; other site 1232724003679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724003680 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232724003681 putative substrate translocation pore; other site 1232724003682 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1232724003683 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1232724003684 putative trimer interface [polypeptide binding]; other site 1232724003685 putative CoA binding site [chemical binding]; other site 1232724003686 PE family; Region: PE; pfam00934 1232724003687 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724003688 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724003689 PPE family; Region: PPE; pfam00823 1232724003690 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1232724003691 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1232724003692 metal binding site [ion binding]; metal-binding site 1232724003693 putative dimer interface [polypeptide binding]; other site 1232724003694 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1232724003695 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1232724003696 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1232724003697 acyl-activating enzyme (AAE) consensus motif; other site 1232724003698 putative AMP binding site [chemical binding]; other site 1232724003699 putative active site [active] 1232724003700 putative CoA binding site [chemical binding]; other site 1232724003701 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1232724003702 dihydropteroate synthase; Region: DHPS; TIGR01496 1232724003703 substrate binding pocket [chemical binding]; other site 1232724003704 dimer interface [polypeptide binding]; other site 1232724003705 inhibitor binding site; inhibition site 1232724003706 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1232724003707 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232724003708 DivIVA domain; Region: DivI1A_domain; TIGR03544 1232724003709 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1232724003710 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1232724003711 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1232724003712 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724003713 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1232724003714 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1232724003715 ligand binding site; other site 1232724003716 oligomer interface; other site 1232724003717 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1232724003718 dimer interface [polypeptide binding]; other site 1232724003719 N-terminal domain interface [polypeptide binding]; other site 1232724003720 sulfate 1 binding site; other site 1232724003721 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1232724003722 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1232724003723 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232724003724 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232724003725 Walker A/P-loop; other site 1232724003726 ATP binding site [chemical binding]; other site 1232724003727 Q-loop/lid; other site 1232724003728 ABC transporter signature motif; other site 1232724003729 Walker B; other site 1232724003730 D-loop; other site 1232724003731 H-loop/switch region; other site 1232724003732 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1232724003733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003735 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1232724003736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724003737 S-adenosylmethionine binding site [chemical binding]; other site 1232724003738 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1232724003739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724003740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724003741 DNA binding residues [nucleotide binding] 1232724003742 Putative zinc-finger; Region: zf-HC2; pfam13490 1232724003743 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1232724003744 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232724003745 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1232724003746 protein binding site [polypeptide binding]; other site 1232724003747 sec-independent translocase; Provisional; Region: PRK03100 1232724003748 Domain of unknown function DUF59; Region: DUF59; cl00941 1232724003749 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1232724003750 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1232724003751 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1232724003752 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1232724003753 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1232724003754 catalytic residue [active] 1232724003755 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1232724003756 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1232724003757 MgtE intracellular N domain; Region: MgtE_N; smart00924 1232724003758 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1232724003759 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1232724003760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1232724003761 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1232724003762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724003763 dimer interface [polypeptide binding]; other site 1232724003764 conserved gate region; other site 1232724003765 putative PBP binding loops; other site 1232724003766 ABC-ATPase subunit interface; other site 1232724003767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1232724003768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724003769 dimer interface [polypeptide binding]; other site 1232724003770 conserved gate region; other site 1232724003771 ABC-ATPase subunit interface; other site 1232724003772 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1232724003773 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1232724003774 Walker A/P-loop; other site 1232724003775 ATP binding site [chemical binding]; other site 1232724003776 Q-loop/lid; other site 1232724003777 ABC transporter signature motif; other site 1232724003778 Walker B; other site 1232724003779 D-loop; other site 1232724003780 H-loop/switch region; other site 1232724003781 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1232724003782 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1232724003783 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1232724003784 oligomer interface [polypeptide binding]; other site 1232724003785 metal binding site [ion binding]; metal-binding site 1232724003786 metal binding site [ion binding]; metal-binding site 1232724003787 putative Cl binding site [ion binding]; other site 1232724003788 basic sphincter; other site 1232724003789 hydrophobic gate; other site 1232724003790 periplasmic entrance; other site 1232724003791 malate dehydrogenase; Provisional; Region: PRK05442 1232724003792 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1232724003793 NAD(P) binding site [chemical binding]; other site 1232724003794 dimer interface [polypeptide binding]; other site 1232724003795 malate binding site [chemical binding]; other site 1232724003796 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1232724003797 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1232724003798 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1232724003799 putative NAD(P) binding site [chemical binding]; other site 1232724003800 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1232724003801 short chain dehydrogenase; Provisional; Region: PRK07832 1232724003802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003803 NAD(P) binding site [chemical binding]; other site 1232724003804 active site 1232724003805 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1232724003806 classical (c) SDRs; Region: SDR_c; cd05233 1232724003807 NAD(P) binding site [chemical binding]; other site 1232724003808 active site 1232724003809 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1232724003810 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232724003811 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1232724003812 TPP-binding site [chemical binding]; other site 1232724003813 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1232724003814 dimer interface [polypeptide binding]; other site 1232724003815 PYR/PP interface [polypeptide binding]; other site 1232724003816 TPP binding site [chemical binding]; other site 1232724003817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724003818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232724003819 putative substrate translocation pore; other site 1232724003820 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1232724003821 RNase_H superfamily; Region: RNase_H_2; pfam13482 1232724003822 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1232724003823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724003824 ATP binding site [chemical binding]; other site 1232724003825 putative Mg++ binding site [ion binding]; other site 1232724003826 AAA domain; Region: AAA_12; pfam13087 1232724003827 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1232724003828 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1232724003829 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1232724003830 ATP binding site [chemical binding]; other site 1232724003831 Mg++ binding site [ion binding]; other site 1232724003832 motif III; other site 1232724003833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724003834 nucleotide binding region [chemical binding]; other site 1232724003835 ATP-binding site [chemical binding]; other site 1232724003836 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1232724003837 putative RNA binding site [nucleotide binding]; other site 1232724003838 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1232724003839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003841 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724003842 Cytochrome P450; Region: p450; cl12078 1232724003843 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1232724003844 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1232724003845 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724003846 Cytochrome P450; Region: p450; cl12078 1232724003847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003849 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724003850 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724003851 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724003852 Cytochrome P450; Region: p450; cl12078 1232724003853 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724003854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003855 NAD(P) binding site [chemical binding]; other site 1232724003856 active site 1232724003857 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1232724003858 classical (c) SDRs; Region: SDR_c; cd05233 1232724003859 NAD(P) binding site [chemical binding]; other site 1232724003860 active site 1232724003861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232724003862 classical (c) SDRs; Region: SDR_c; cd05233 1232724003863 NAD(P) binding site [chemical binding]; other site 1232724003864 active site 1232724003865 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724003866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003867 NAD(P) binding site [chemical binding]; other site 1232724003868 active site 1232724003869 short chain dehydrogenase; Provisional; Region: PRK08303 1232724003870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724003871 NAD(P) binding site [chemical binding]; other site 1232724003872 active site 1232724003873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724003874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724003875 Transposase; Region: HTH_Tnp_1; cl17663 1232724003876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1232724003877 putative transposase OrfB; Reviewed; Region: PHA02517 1232724003878 HTH-like domain; Region: HTH_21; pfam13276 1232724003879 Integrase core domain; Region: rve; pfam00665 1232724003880 Integrase core domain; Region: rve_3; cl15866 1232724003881 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1232724003882 YfbU domain; Region: YfbU; cl01137 1232724003883 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1232724003884 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1232724003885 catalytic residues [active] 1232724003886 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1232724003887 DNA-binding interface [nucleotide binding]; DNA binding site 1232724003888 Divergent AAA domain; Region: AAA_4; pfam04326 1232724003889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724003890 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232724003891 Integrase core domain; Region: rve; pfam00665 1232724003892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724003893 Walker A motif; other site 1232724003894 ATP binding site [chemical binding]; other site 1232724003895 Walker B motif; other site 1232724003896 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1232724003897 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724003898 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1232724003899 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1232724003900 Fe-S cluster binding site [ion binding]; other site 1232724003901 DNA binding site [nucleotide binding] 1232724003902 active site 1232724003903 hypothetical protein; Validated; Region: PRK05868 1232724003904 hypothetical protein; Provisional; Region: PRK07236 1232724003905 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1232724003906 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724003907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1232724003908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232724003909 metal binding site [ion binding]; metal-binding site 1232724003910 active site 1232724003911 I-site; other site 1232724003912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232724003913 metal binding site [ion binding]; metal-binding site 1232724003914 active site 1232724003915 I-site; other site 1232724003916 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1232724003917 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1232724003918 HIT family signature motif; other site 1232724003919 catalytic residue [active] 1232724003920 amidase; Provisional; Region: PRK12470 1232724003921 Amidase; Region: Amidase; pfam01425 1232724003922 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1232724003923 putative active site [active] 1232724003924 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724003925 cyclase homology domain; Region: CHD; cd07302 1232724003926 nucleotidyl binding site; other site 1232724003927 metal binding site [ion binding]; metal-binding site 1232724003928 dimer interface [polypeptide binding]; other site 1232724003929 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724003930 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724003931 active site 1232724003932 ATP binding site [chemical binding]; other site 1232724003933 substrate binding site [chemical binding]; other site 1232724003934 activation loop (A-loop); other site 1232724003935 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724003936 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232724003937 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1232724003938 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232724003939 Walker A/P-loop; other site 1232724003940 ATP binding site [chemical binding]; other site 1232724003941 Q-loop/lid; other site 1232724003942 ABC transporter signature motif; other site 1232724003943 Walker B; other site 1232724003944 D-loop; other site 1232724003945 H-loop/switch region; other site 1232724003946 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232724003947 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232724003948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724003949 Walker A/P-loop; other site 1232724003950 ATP binding site [chemical binding]; other site 1232724003951 Q-loop/lid; other site 1232724003952 ABC transporter signature motif; other site 1232724003953 Walker B; other site 1232724003954 D-loop; other site 1232724003955 H-loop/switch region; other site 1232724003956 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1232724003957 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1232724003958 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724003959 catalytic core [active] 1232724003960 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1232724003961 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1232724003962 active site 1232724003963 metal binding site [ion binding]; metal-binding site 1232724003964 DNA binding site [nucleotide binding] 1232724003965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724003966 Walker A/P-loop; other site 1232724003967 ATP binding site [chemical binding]; other site 1232724003968 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724003969 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1232724003970 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1232724003971 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1232724003972 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232724003973 Walker A/P-loop; other site 1232724003974 ATP binding site [chemical binding]; other site 1232724003975 Q-loop/lid; other site 1232724003976 ABC transporter signature motif; other site 1232724003977 Walker B; other site 1232724003978 D-loop; other site 1232724003979 H-loop/switch region; other site 1232724003980 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1232724003981 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232724003982 Walker A/P-loop; other site 1232724003983 ATP binding site [chemical binding]; other site 1232724003984 Q-loop/lid; other site 1232724003985 ABC transporter signature motif; other site 1232724003986 Walker B; other site 1232724003987 D-loop; other site 1232724003988 H-loop/switch region; other site 1232724003989 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1232724003990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1232724003991 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1232724003992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724003993 dimer interface [polypeptide binding]; other site 1232724003994 conserved gate region; other site 1232724003995 putative PBP binding loops; other site 1232724003996 ABC-ATPase subunit interface; other site 1232724003997 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1232724003998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724003999 dimer interface [polypeptide binding]; other site 1232724004000 conserved gate region; other site 1232724004001 putative PBP binding loops; other site 1232724004002 ABC-ATPase subunit interface; other site 1232724004003 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1232724004004 active site clefts [active] 1232724004005 zinc binding site [ion binding]; other site 1232724004006 dimer interface [polypeptide binding]; other site 1232724004007 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724004008 CoenzymeA binding site [chemical binding]; other site 1232724004009 subunit interaction site [polypeptide binding]; other site 1232724004010 PHB binding site; other site 1232724004011 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1232724004012 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1232724004013 Active Sites [active] 1232724004014 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1232724004015 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1232724004016 CysD dimerization site [polypeptide binding]; other site 1232724004017 G1 box; other site 1232724004018 putative GEF interaction site [polypeptide binding]; other site 1232724004019 GTP/Mg2+ binding site [chemical binding]; other site 1232724004020 Switch I region; other site 1232724004021 G2 box; other site 1232724004022 G3 box; other site 1232724004023 Switch II region; other site 1232724004024 G4 box; other site 1232724004025 G5 box; other site 1232724004026 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1232724004027 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1232724004028 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1232724004029 ligand-binding site [chemical binding]; other site 1232724004030 Rrf2 family protein; Region: rrf2_super; TIGR00738 1232724004031 Transcriptional regulator; Region: Rrf2; pfam02082 1232724004032 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 1232724004033 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724004034 metal binding site [ion binding]; metal-binding site 1232724004035 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1232724004036 putative dimer interface [polypeptide binding]; other site 1232724004037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724004038 ligand binding site [chemical binding]; other site 1232724004039 Zn binding site [ion binding]; other site 1232724004040 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724004041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1232724004042 TrkA-N domain; Region: TrkA_N; pfam02254 1232724004043 Ion channel; Region: Ion_trans_2; pfam07885 1232724004044 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1232724004045 TrkA-N domain; Region: TrkA_N; pfam02254 1232724004046 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724004047 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1232724004048 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1232724004049 dimer interface [polypeptide binding]; other site 1232724004050 ADP-ribose binding site [chemical binding]; other site 1232724004051 active site 1232724004052 nudix motif; other site 1232724004053 metal binding site [ion binding]; metal-binding site 1232724004054 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1232724004055 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1232724004056 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1232724004057 active site 1232724004058 HIGH motif; other site 1232724004059 KMSK motif region; other site 1232724004060 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1232724004061 tRNA binding surface [nucleotide binding]; other site 1232724004062 anticodon binding site; other site 1232724004063 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1232724004064 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1232724004065 active site 1232724004066 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232724004067 substrate binding site [chemical binding]; other site 1232724004068 catalytic residues [active] 1232724004069 dimer interface [polypeptide binding]; other site 1232724004070 homoserine dehydrogenase; Provisional; Region: PRK06349 1232724004071 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1232724004072 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1232724004073 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1232724004074 threonine synthase; Reviewed; Region: PRK06721 1232724004075 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1232724004076 homodimer interface [polypeptide binding]; other site 1232724004077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724004078 catalytic residue [active] 1232724004079 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1232724004080 frameshift; transcription termination factor Rho 1232724004081 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1232724004082 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1232724004083 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1232724004084 RF-1 domain; Region: RF-1; pfam00472 1232724004085 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1232724004086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724004087 S-adenosylmethionine binding site [chemical binding]; other site 1232724004088 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1232724004089 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1232724004090 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1232724004091 Mg++ binding site [ion binding]; other site 1232724004092 putative catalytic motif [active] 1232724004093 substrate binding site [chemical binding]; other site 1232724004094 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1232724004095 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1232724004096 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1232724004097 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1232724004098 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1232724004099 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1232724004100 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1232724004101 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1232724004102 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1232724004103 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1232724004104 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1232724004105 beta subunit interaction interface [polypeptide binding]; other site 1232724004106 Walker A motif; other site 1232724004107 ATP binding site [chemical binding]; other site 1232724004108 Walker B motif; other site 1232724004109 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1232724004110 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1232724004111 core domain interface [polypeptide binding]; other site 1232724004112 delta subunit interface [polypeptide binding]; other site 1232724004113 epsilon subunit interface [polypeptide binding]; other site 1232724004114 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1232724004115 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1232724004116 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1232724004117 alpha subunit interaction interface [polypeptide binding]; other site 1232724004118 Walker A motif; other site 1232724004119 ATP binding site [chemical binding]; other site 1232724004120 Walker B motif; other site 1232724004121 inhibitor binding site; inhibition site 1232724004122 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1232724004123 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1232724004124 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1232724004125 gamma subunit interface [polypeptide binding]; other site 1232724004126 epsilon subunit interface [polypeptide binding]; other site 1232724004127 LBP interface [polypeptide binding]; other site 1232724004128 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1232724004129 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1232724004130 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1232724004131 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1232724004132 hinge; other site 1232724004133 active site 1232724004134 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724004135 PPE family; Region: PPE; pfam00823 1232724004136 PE family; Region: PE; pfam00934 1232724004137 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724004138 PPE family; Region: PPE; pfam00823 1232724004139 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724004140 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1232724004141 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1232724004142 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1232724004143 DNA binding site [nucleotide binding] 1232724004144 active site 1232724004145 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1232724004146 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1232724004147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724004148 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1232724004149 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1232724004150 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1232724004151 minor groove reading motif; other site 1232724004152 helix-hairpin-helix signature motif; other site 1232724004153 substrate binding pocket [chemical binding]; other site 1232724004154 active site 1232724004155 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1232724004156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232724004157 metal binding site [ion binding]; metal-binding site 1232724004158 active site 1232724004159 I-site; other site 1232724004160 HAMP domain; Region: HAMP; pfam00672 1232724004161 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724004162 cyclase homology domain; Region: CHD; cd07302 1232724004163 nucleotidyl binding site; other site 1232724004164 metal binding site [ion binding]; metal-binding site 1232724004165 dimer interface [polypeptide binding]; other site 1232724004166 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1232724004167 hypothetical protein; Provisional; Region: PRK03298 1232724004168 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1232724004169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724004170 dimer interface [polypeptide binding]; other site 1232724004171 substrate binding site [chemical binding]; other site 1232724004172 metal binding site [ion binding]; metal-binding site 1232724004173 putative acyltransferase; Provisional; Region: PRK05790 1232724004174 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724004175 dimer interface [polypeptide binding]; other site 1232724004176 active site 1232724004177 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1232724004178 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1232724004179 glycogen branching enzyme; Provisional; Region: PRK05402 1232724004180 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1232724004181 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1232724004182 active site 1232724004183 catalytic site [active] 1232724004184 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1232724004185 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1232724004186 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1232724004187 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1232724004188 active site 1232724004189 homodimer interface [polypeptide binding]; other site 1232724004190 catalytic site [active] 1232724004191 acceptor binding site [chemical binding]; other site 1232724004192 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1232724004193 putative homodimer interface [polypeptide binding]; other site 1232724004194 putative active site pocket [active] 1232724004195 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1232724004196 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1232724004197 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1232724004198 ATP binding site [chemical binding]; other site 1232724004199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1232724004200 putative Mg++ binding site [ion binding]; other site 1232724004201 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1232724004202 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1232724004203 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1232724004204 active site 1232724004205 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1232724004206 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1232724004207 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1232724004208 putative active site pocket [active] 1232724004209 cleavage site 1232724004210 Rhomboid family; Region: Rhomboid; pfam01694 1232724004211 glutamate racemase; Provisional; Region: PRK00865 1232724004212 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1232724004213 ribonuclease PH; Reviewed; Region: rph; PRK00173 1232724004214 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1232724004215 hexamer interface [polypeptide binding]; other site 1232724004216 active site 1232724004217 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1232724004218 active site 1232724004219 dimerization interface [polypeptide binding]; other site 1232724004220 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1232724004221 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1232724004222 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1232724004223 Protein of unknown function, DUF393; Region: DUF393; cl01136 1232724004224 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1232724004225 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1232724004226 FAD binding pocket [chemical binding]; other site 1232724004227 FAD binding motif [chemical binding]; other site 1232724004228 phosphate binding motif [ion binding]; other site 1232724004229 NAD binding pocket [chemical binding]; other site 1232724004230 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232724004231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724004232 Walker A/P-loop; other site 1232724004233 ATP binding site [chemical binding]; other site 1232724004234 Q-loop/lid; other site 1232724004235 ABC transporter signature motif; other site 1232724004236 Walker B; other site 1232724004237 D-loop; other site 1232724004238 H-loop/switch region; other site 1232724004239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724004240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232724004241 Walker A/P-loop; other site 1232724004242 ATP binding site [chemical binding]; other site 1232724004243 Q-loop/lid; other site 1232724004244 ABC transporter signature motif; other site 1232724004245 Walker B; other site 1232724004246 D-loop; other site 1232724004247 H-loop/switch region; other site 1232724004248 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724004249 Ecdysteroid kinase; Region: EcKinase; cl17738 1232724004250 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724004251 cyclase homology domain; Region: CHD; cd07302 1232724004252 nucleotidyl binding site; other site 1232724004253 metal binding site [ion binding]; metal-binding site 1232724004254 dimer interface [polypeptide binding]; other site 1232724004255 Predicted ATPase [General function prediction only]; Region: COG3903 1232724004256 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724004257 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724004258 DNA binding residues [nucleotide binding] 1232724004259 dimerization interface [polypeptide binding]; other site 1232724004260 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1232724004261 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724004262 classical (c) SDRs; Region: SDR_c; cd05233 1232724004263 NAD(P) binding site [chemical binding]; other site 1232724004264 active site 1232724004265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004267 active site 1232724004268 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724004269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724004270 NAD(P) binding site [chemical binding]; other site 1232724004271 active site 1232724004272 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1232724004273 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724004274 dimer interface [polypeptide binding]; other site 1232724004275 active site 1232724004276 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1232724004277 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724004278 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004280 active site 1232724004281 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232724004282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724004283 DNA-binding site [nucleotide binding]; DNA binding site 1232724004284 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1232724004285 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1232724004286 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1232724004287 conserved cys residue [active] 1232724004288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724004289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724004290 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1232724004291 conserved cys residue [active] 1232724004292 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724004293 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724004294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724004295 acyl-activating enzyme (AAE) consensus motif; other site 1232724004296 acyl-activating enzyme (AAE) consensus motif; other site 1232724004297 AMP binding site [chemical binding]; other site 1232724004298 active site 1232724004299 CoA binding site [chemical binding]; other site 1232724004300 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724004301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724004302 acyl-activating enzyme (AAE) consensus motif; other site 1232724004303 AMP binding site [chemical binding]; other site 1232724004304 active site 1232724004305 CoA binding site [chemical binding]; other site 1232724004306 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724004307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724004308 AMP binding site [chemical binding]; other site 1232724004309 active site 1232724004310 acyl-activating enzyme (AAE) consensus motif; other site 1232724004311 CoA binding site [chemical binding]; other site 1232724004312 enoyl-CoA hydratase; Provisional; Region: PRK05981 1232724004313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724004314 substrate binding site [chemical binding]; other site 1232724004315 oxyanion hole (OAH) forming residues; other site 1232724004316 trimer interface [polypeptide binding]; other site 1232724004317 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724004318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724004319 substrate binding site [chemical binding]; other site 1232724004320 oxyanion hole (OAH) forming residues; other site 1232724004321 trimer interface [polypeptide binding]; other site 1232724004322 phenylacetate degradation probable enoyl-CoA hydratase paaB; Region: PaaB1; TIGR02280 1232724004323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724004324 substrate binding site [chemical binding]; other site 1232724004325 oxyanion hole (OAH) forming residues; other site 1232724004326 trimer interface [polypeptide binding]; other site 1232724004327 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724004328 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1232724004329 substrate binding site [chemical binding]; other site 1232724004330 oxyanion hole (OAH) forming residues; other site 1232724004331 trimer interface [polypeptide binding]; other site 1232724004332 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1232724004333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724004334 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232724004335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724004336 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724004337 NAD(P) binding site [chemical binding]; other site 1232724004338 active site 1232724004339 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1232724004340 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1232724004341 active site 1232724004342 inhibitor site; inhibition site 1232724004343 dimer interface [polypeptide binding]; other site 1232724004344 catalytic residue [active] 1232724004345 enoyl-CoA hydratase; Provisional; Region: PRK06210 1232724004346 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724004347 substrate binding site [chemical binding]; other site 1232724004348 oxyanion hole (OAH) forming residues; other site 1232724004349 trimer interface [polypeptide binding]; other site 1232724004350 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724004351 acyl-CoA synthetase; Validated; Region: PRK07798 1232724004352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724004353 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1232724004354 acyl-activating enzyme (AAE) consensus motif; other site 1232724004355 acyl-activating enzyme (AAE) consensus motif; other site 1232724004356 putative AMP binding site [chemical binding]; other site 1232724004357 putative active site [active] 1232724004358 putative CoA binding site [chemical binding]; other site 1232724004359 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724004360 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1232724004361 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724004362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004363 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004365 active site 1232724004366 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724004367 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1232724004368 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724004369 active site 1232724004370 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724004371 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724004372 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724004373 Cytochrome P450; Region: p450; cl12078 1232724004374 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232724004375 NAD(P) binding site [chemical binding]; other site 1232724004376 catalytic residues [active] 1232724004377 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724004378 Cytochrome P450; Region: p450; cl12078 1232724004379 short chain dehydrogenase; Provisional; Region: PRK07832 1232724004380 classical (c) SDRs; Region: SDR_c; cd05233 1232724004381 NAD(P) binding site [chemical binding]; other site 1232724004382 active site 1232724004383 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724004384 hydrophobic ligand binding site; other site 1232724004385 acyl-CoA synthetase; Validated; Region: PRK07798 1232724004386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724004387 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1232724004388 acyl-activating enzyme (AAE) consensus motif; other site 1232724004389 acyl-activating enzyme (AAE) consensus motif; other site 1232724004390 putative AMP binding site [chemical binding]; other site 1232724004391 putative active site [active] 1232724004392 putative CoA binding site [chemical binding]; other site 1232724004393 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724004394 CoenzymeA binding site [chemical binding]; other site 1232724004395 subunit interaction site [polypeptide binding]; other site 1232724004396 PHB binding site; other site 1232724004397 Isochorismatase family; Region: Isochorismatase; pfam00857 1232724004398 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1232724004399 catalytic triad [active] 1232724004400 conserved cis-peptide bond; other site 1232724004401 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724004402 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724004403 [2Fe-2S] cluster binding site [ion binding]; other site 1232724004404 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724004405 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724004406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724004407 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724004408 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1232724004409 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724004410 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232724004411 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232724004412 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724004413 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724004414 Cytochrome P450; Region: p450; cl12078 1232724004415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724004416 short chain dehydrogenase; Provisional; Region: PRK06197 1232724004417 NAD(P) binding site [chemical binding]; other site 1232724004418 active site 1232724004419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724004420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724004421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724004422 Walker A/P-loop; other site 1232724004423 ATP binding site [chemical binding]; other site 1232724004424 Predicted membrane protein [Function unknown]; Region: COG1511 1232724004425 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1232724004426 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1232724004427 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1232724004428 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232724004429 NAD binding site [chemical binding]; other site 1232724004430 catalytic Zn binding site [ion binding]; other site 1232724004431 substrate binding site [chemical binding]; other site 1232724004432 structural Zn binding site [ion binding]; other site 1232724004433 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724004434 Cytochrome P450; Region: p450; cl12078 1232724004435 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724004436 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724004437 substrate binding pocket [chemical binding]; other site 1232724004438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004439 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724004440 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724004441 active site 1232724004442 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004444 active site 1232724004445 PAS fold; Region: PAS_4; pfam08448 1232724004446 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1232724004447 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1232724004448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1232724004449 ATP binding site [chemical binding]; other site 1232724004450 Mg2+ binding site [ion binding]; other site 1232724004451 G-X-G motif; other site 1232724004452 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724004453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724004454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724004455 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724004456 CoenzymeA binding site [chemical binding]; other site 1232724004457 subunit interaction site [polypeptide binding]; other site 1232724004458 PHB binding site; other site 1232724004459 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724004460 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724004461 putative AMP binding site [chemical binding]; other site 1232724004462 putative active site [active] 1232724004463 acyl-activating enzyme (AAE) consensus motif; other site 1232724004464 putative CoA binding site [chemical binding]; other site 1232724004465 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1232724004466 active site 1232724004467 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004468 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004469 active site 1232724004470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004472 active site 1232724004473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004475 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724004476 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724004477 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1232724004478 classical (c) SDRs; Region: SDR_c; cd05233 1232724004479 NAD(P) binding site [chemical binding]; other site 1232724004480 active site 1232724004481 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232724004482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724004483 DNA-binding site [nucleotide binding]; DNA binding site 1232724004484 FCD domain; Region: FCD; pfam07729 1232724004485 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724004486 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724004487 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724004488 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724004489 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1232724004490 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1232724004491 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724004492 Cytochrome P450; Region: p450; cl12078 1232724004493 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724004494 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724004495 [2Fe-2S] cluster binding site [ion binding]; other site 1232724004496 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724004497 hydrophobic ligand binding site; other site 1232724004498 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1232724004499 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1232724004500 acyl-activating enzyme (AAE) consensus motif; other site 1232724004501 putative AMP binding site [chemical binding]; other site 1232724004502 putative active site [active] 1232724004503 putative CoA binding site [chemical binding]; other site 1232724004504 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724004505 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232724004506 active site 1232724004507 catalytic site [active] 1232724004508 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1232724004509 putative active site [active] 1232724004510 putative catalytic site [active] 1232724004511 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724004512 TIGR03086 family protein; Region: TIGR03086 1232724004513 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1232724004514 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724004515 NAD binding site [chemical binding]; other site 1232724004516 catalytic residues [active] 1232724004517 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1232724004518 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724004519 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724004520 [2Fe-2S] cluster binding site [ion binding]; other site 1232724004521 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1232724004522 putative alpha subunit interface [polypeptide binding]; other site 1232724004523 putative active site [active] 1232724004524 putative substrate binding site [chemical binding]; other site 1232724004525 Fe binding site [ion binding]; other site 1232724004526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724004527 sequence-specific DNA binding site [nucleotide binding]; other site 1232724004528 salt bridge; other site 1232724004529 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1232724004530 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232724004531 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1232724004532 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232724004533 phosphate binding site [ion binding]; other site 1232724004534 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1232724004535 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1232724004536 putative active site [active] 1232724004537 putative catalytic site [active] 1232724004538 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232724004539 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232724004540 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1232724004541 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1232724004542 putative NAD(P) binding site [chemical binding]; other site 1232724004543 active site 1232724004544 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1232724004545 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1232724004546 active site 1232724004547 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1232724004548 hypothetical protein; Provisional; Region: PRK07907 1232724004549 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1232724004550 active site 1232724004551 metal binding site [ion binding]; metal-binding site 1232724004552 dimer interface [polypeptide binding]; other site 1232724004553 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724004554 Cytochrome P450; Region: p450; cl12078 1232724004555 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1232724004556 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232724004557 catalytic triad [active] 1232724004558 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1232724004559 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1232724004560 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232724004561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232724004562 active site 1232724004563 DNA binding site [nucleotide binding] 1232724004564 Int/Topo IB signature motif; other site 1232724004565 Helix-turn-helix domain; Region: HTH_17; cl17695 1232724004566 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1232724004567 polymerase nucleotide-binding site; other site 1232724004568 DNA-binding residues [nucleotide binding]; DNA binding site 1232724004569 nucleotide binding site [chemical binding]; other site 1232724004570 primase nucleotide-binding site [nucleotide binding]; other site 1232724004571 AAA domain; Region: AAA_25; pfam13481 1232724004572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724004573 ATP binding site [chemical binding]; other site 1232724004574 putative Mg++ binding site [ion binding]; other site 1232724004575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724004576 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1232724004577 nucleotide binding region [chemical binding]; other site 1232724004578 ATP-binding site [chemical binding]; other site 1232724004579 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1232724004580 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1232724004581 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1232724004582 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1232724004583 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1232724004584 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1232724004585 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1232724004586 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1232724004587 catalytic residues [active] 1232724004588 catalytic nucleophile [active] 1232724004589 Presynaptic Site I dimer interface [polypeptide binding]; other site 1232724004590 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1232724004591 Synaptic Flat tetramer interface [polypeptide binding]; other site 1232724004592 Synaptic Site I dimer interface [polypeptide binding]; other site 1232724004593 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1232724004594 transposase/IS protein; Provisional; Region: PRK09183 1232724004595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724004596 Walker A motif; other site 1232724004597 ATP binding site [chemical binding]; other site 1232724004598 Walker B motif; other site 1232724004599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724004600 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724004601 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724004602 active site 1232724004603 ATP binding site [chemical binding]; other site 1232724004604 substrate binding site [chemical binding]; other site 1232724004605 activation loop (A-loop); other site 1232724004606 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724004607 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724004608 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724004609 active site 1232724004610 ATP binding site [chemical binding]; other site 1232724004611 substrate binding site [chemical binding]; other site 1232724004612 activation loop (A-loop); other site 1232724004613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724004614 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724004615 active site 1232724004616 ATP binding site [chemical binding]; other site 1232724004617 substrate binding site [chemical binding]; other site 1232724004618 activation loop (A-loop); other site 1232724004619 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1232724004620 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1232724004621 catalytic residues [active] 1232724004622 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724004623 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724004624 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724004625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724004626 non-specific DNA binding site [nucleotide binding]; other site 1232724004627 salt bridge; other site 1232724004628 sequence-specific DNA binding site [nucleotide binding]; other site 1232724004629 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724004630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724004631 non-specific DNA binding site [nucleotide binding]; other site 1232724004632 salt bridge; other site 1232724004633 sequence-specific DNA binding site [nucleotide binding]; other site 1232724004634 hypothetical protein; Provisional; Region: PRK01346 1232724004635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1232724004636 MMPL family; Region: MMPL; pfam03176 1232724004637 MMPL family; Region: MMPL; pfam03176 1232724004638 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1232724004639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232724004640 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1232724004641 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232724004642 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1232724004643 catalytic site [active] 1232724004644 putative active site [active] 1232724004645 putative substrate binding site [chemical binding]; other site 1232724004646 dimer interface [polypeptide binding]; other site 1232724004647 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1232724004648 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232724004649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724004650 NAD(P) binding site [chemical binding]; other site 1232724004651 active site 1232724004652 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1232724004653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724004654 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724004655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724004656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724004657 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1232724004658 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232724004659 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724004660 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1232724004661 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232724004662 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1232724004663 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232724004664 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232724004665 carboxyltransferase (CT) interaction site; other site 1232724004666 biotinylation site [posttranslational modification]; other site 1232724004667 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724004668 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724004669 active site 1232724004670 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1232724004671 putative active site [active] 1232724004672 putative catalytic site [active] 1232724004673 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1232724004674 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1232724004675 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1232724004676 tetramer interface [polypeptide binding]; other site 1232724004677 TPP-binding site [chemical binding]; other site 1232724004678 heterodimer interface [polypeptide binding]; other site 1232724004679 phosphorylation loop region [posttranslational modification] 1232724004680 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1232724004681 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1232724004682 alpha subunit interface [polypeptide binding]; other site 1232724004683 TPP binding site [chemical binding]; other site 1232724004684 heterodimer interface [polypeptide binding]; other site 1232724004685 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1232724004686 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232724004687 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1232724004688 E3 interaction surface; other site 1232724004689 lipoyl attachment site [posttranslational modification]; other site 1232724004690 e3 binding domain; Region: E3_binding; pfam02817 1232724004691 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232724004692 enoyl-CoA hydratase; Provisional; Region: PRK05870 1232724004693 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724004694 substrate binding site [chemical binding]; other site 1232724004695 oxyanion hole (OAH) forming residues; other site 1232724004696 trimer interface [polypeptide binding]; other site 1232724004697 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1232724004698 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724004699 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724004700 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724004701 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724004702 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1232724004703 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1232724004704 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724004705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232724004706 putative acyl-acceptor binding pocket; other site 1232724004707 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1232724004708 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1232724004709 putative acyl-acceptor binding pocket; other site 1232724004710 Copper resistance protein D; Region: CopD; pfam05425 1232724004711 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1232724004712 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1232724004713 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1232724004714 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1232724004715 dimer interface [polypeptide binding]; other site 1232724004716 ssDNA binding site [nucleotide binding]; other site 1232724004717 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232724004718 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1232724004719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724004720 Walker A/P-loop; other site 1232724004721 ATP binding site [chemical binding]; other site 1232724004722 Q-loop/lid; other site 1232724004723 ABC transporter signature motif; other site 1232724004724 Walker B; other site 1232724004725 D-loop; other site 1232724004726 H-loop/switch region; other site 1232724004727 ABC transporter; Region: ABC_tran_2; pfam12848 1232724004728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232724004729 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1232724004730 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1232724004731 active site 1232724004732 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724004733 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1232724004734 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1232724004735 active site 1232724004736 catalytic site [active] 1232724004737 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1232724004738 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1232724004739 apolar tunnel; other site 1232724004740 heme binding site [chemical binding]; other site 1232724004741 dimerization interface [polypeptide binding]; other site 1232724004742 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1232724004743 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724004744 active site 1232724004745 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1232724004746 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1232724004747 Zn binding site [ion binding]; other site 1232724004748 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232724004749 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1232724004750 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1232724004751 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1232724004752 putative DNA binding site [nucleotide binding]; other site 1232724004753 catalytic residue [active] 1232724004754 putative H2TH interface [polypeptide binding]; other site 1232724004755 putative catalytic residues [active] 1232724004756 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232724004757 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232724004758 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724004759 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724004760 trigger factor; Provisional; Region: tig; PRK01490 1232724004761 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1232724004762 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1232724004763 Clp protease; Region: CLP_protease; pfam00574 1232724004764 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1232724004765 oligomer interface [polypeptide binding]; other site 1232724004766 active site residues [active] 1232724004767 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1232724004768 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1232724004769 oligomer interface [polypeptide binding]; other site 1232724004770 active site residues [active] 1232724004771 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1232724004772 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1232724004773 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1232724004774 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1232724004775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724004776 Walker A motif; other site 1232724004777 ATP binding site [chemical binding]; other site 1232724004778 Walker B motif; other site 1232724004779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1232724004780 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1232724004781 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1232724004782 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1232724004783 dimer interface [polypeptide binding]; other site 1232724004784 PYR/PP interface [polypeptide binding]; other site 1232724004785 TPP binding site [chemical binding]; other site 1232724004786 substrate binding site [chemical binding]; other site 1232724004787 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1232724004788 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1232724004789 TPP-binding site [chemical binding]; other site 1232724004790 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1232724004791 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1232724004792 GTP binding site; other site 1232724004793 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1232724004794 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1232724004795 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1232724004796 NAD(P) binding pocket [chemical binding]; other site 1232724004797 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1232724004798 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724004799 active site 1232724004800 HIGH motif; other site 1232724004801 nucleotide binding site [chemical binding]; other site 1232724004802 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1232724004803 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1232724004804 active site 1232724004805 KMSKS motif; other site 1232724004806 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1232724004807 tRNA binding surface [nucleotide binding]; other site 1232724004808 anticodon binding site; other site 1232724004809 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1232724004810 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1232724004811 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232724004812 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1232724004813 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1232724004814 active site 1232724004815 multimer interface [polypeptide binding]; other site 1232724004816 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1232724004817 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1232724004818 homodimer interface [polypeptide binding]; other site 1232724004819 oligonucleotide binding site [chemical binding]; other site 1232724004820 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1232724004821 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1232724004822 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1232724004823 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1232724004824 GTP1/OBG; Region: GTP1_OBG; pfam01018 1232724004825 Obg GTPase; Region: Obg; cd01898 1232724004826 G1 box; other site 1232724004827 GTP/Mg2+ binding site [chemical binding]; other site 1232724004828 Switch I region; other site 1232724004829 G2 box; other site 1232724004830 G3 box; other site 1232724004831 Switch II region; other site 1232724004832 G4 box; other site 1232724004833 G5 box; other site 1232724004834 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1232724004835 gamma-glutamyl kinase; Provisional; Region: PRK05429 1232724004836 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1232724004837 nucleotide binding site [chemical binding]; other site 1232724004838 homotetrameric interface [polypeptide binding]; other site 1232724004839 putative phosphate binding site [ion binding]; other site 1232724004840 putative allosteric binding site; other site 1232724004841 PUA domain; Region: PUA; pfam01472 1232724004842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724004843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724004844 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724004845 Cytochrome P450; Region: p450; cl12078 1232724004846 NAD-dependent deacetylase; Provisional; Region: PRK00481 1232724004847 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1232724004848 NAD+ binding site [chemical binding]; other site 1232724004849 substrate binding site [chemical binding]; other site 1232724004850 Zn binding site [ion binding]; other site 1232724004851 Isochorismatase family; Region: Isochorismatase; pfam00857 1232724004852 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1232724004853 catalytic triad [active] 1232724004854 conserved cis-peptide bond; other site 1232724004855 NAD synthetase; Reviewed; Region: nadE; PRK02628 1232724004856 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1232724004857 multimer interface [polypeptide binding]; other site 1232724004858 active site 1232724004859 catalytic triad [active] 1232724004860 protein interface 1 [polypeptide binding]; other site 1232724004861 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1232724004862 homodimer interface [polypeptide binding]; other site 1232724004863 NAD binding pocket [chemical binding]; other site 1232724004864 ATP binding pocket [chemical binding]; other site 1232724004865 Mg binding site [ion binding]; other site 1232724004866 active-site loop [active] 1232724004867 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232724004868 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1232724004869 substrate binding site [chemical binding]; other site 1232724004870 dimer interface [polypeptide binding]; other site 1232724004871 ATP binding site [chemical binding]; other site 1232724004872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232724004873 dimerization interface [polypeptide binding]; other site 1232724004874 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1232724004875 cyclase homology domain; Region: CHD; cd07302 1232724004876 nucleotidyl binding site; other site 1232724004877 metal binding site [ion binding]; metal-binding site 1232724004878 dimer interface [polypeptide binding]; other site 1232724004879 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1232724004880 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232724004881 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232724004882 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232724004883 ligand binding site [chemical binding]; other site 1232724004884 flexible hinge region; other site 1232724004885 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1232724004886 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1232724004887 putative catalytic cysteine [active] 1232724004888 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1232724004889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724004890 Walker A motif; other site 1232724004891 ATP binding site [chemical binding]; other site 1232724004892 Walker B motif; other site 1232724004893 arginine finger; other site 1232724004894 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1232724004895 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1232724004896 metal ion-dependent adhesion site (MIDAS); other site 1232724004897 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1232724004898 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1232724004899 active site 1232724004900 (T/H)XGH motif; other site 1232724004901 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1232724004902 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724004903 catalytic core [active] 1232724004904 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1232724004905 active site 1232724004906 catalytic triad [active] 1232724004907 oxyanion hole [active] 1232724004908 EDD domain protein, DegV family; Region: DegV; TIGR00762 1232724004909 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1232724004910 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1232724004911 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724004912 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724004913 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 1232724004914 acyl-CoA synthetase; Validated; Region: PRK05850 1232724004915 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1232724004916 acyl-activating enzyme (AAE) consensus motif; other site 1232724004917 active site 1232724004918 PE-PPE domain; Region: PE-PPE; pfam08237 1232724004919 Transport protein; Region: actII; TIGR00833 1232724004920 Condensation domain; Region: Condensation; pfam00668 1232724004921 frameshift; Erythronolide synthase, modules 3 and 4 1232724004922 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1232724004923 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1232724004924 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724004925 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724004926 active site 1232724004927 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1232724004928 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1232724004929 FAD binding site [chemical binding]; other site 1232724004930 substrate binding site [chemical binding]; other site 1232724004931 catalytic base [active] 1232724004932 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1232724004933 Helix-hairpin-helix motif; Region: HHH; pfam00633 1232724004934 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1232724004935 Competence protein; Region: Competence; pfam03772 1232724004936 hypothetical protein; Reviewed; Region: PRK07914 1232724004937 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1232724004938 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1232724004939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1232724004940 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1232724004941 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1232724004942 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1232724004943 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1232724004944 Predicted transcriptional regulators [Transcription]; Region: COG1733 1232724004945 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1232724004946 DoxX-like family; Region: DoxX_2; pfam13564 1232724004947 ribonuclease Z; Reviewed; Region: PRK00055 1232724004948 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1232724004949 FOG: CBS domain [General function prediction only]; Region: COG0517 1232724004950 PemK-like protein; Region: PemK; pfam02452 1232724004951 GTP-binding protein LepA; Provisional; Region: PRK05433 1232724004952 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1232724004953 putative GEF interaction site [polypeptide binding]; other site 1232724004954 Switch I region; other site 1232724004955 G2 box; other site 1232724004956 G3 box; other site 1232724004957 Switch II region; other site 1232724004958 GTP/Mg2+ binding site [chemical binding]; other site 1232724004959 G4 box; other site 1232724004960 G5 box; other site 1232724004961 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1232724004962 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1232724004963 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1232724004964 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724004965 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724004966 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1232724004967 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1232724004968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1232724004969 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1232724004970 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1232724004971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724004972 dimer interface [polypeptide binding]; other site 1232724004973 conserved gate region; other site 1232724004974 putative PBP binding loops; other site 1232724004975 ABC-ATPase subunit interface; other site 1232724004976 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1232724004977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724004978 dimer interface [polypeptide binding]; other site 1232724004979 conserved gate region; other site 1232724004980 putative PBP binding loops; other site 1232724004981 ABC-ATPase subunit interface; other site 1232724004982 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1232724004983 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1232724004984 Walker A/P-loop; other site 1232724004985 ATP binding site [chemical binding]; other site 1232724004986 Q-loop/lid; other site 1232724004987 ABC transporter signature motif; other site 1232724004988 Walker B; other site 1232724004989 D-loop; other site 1232724004990 H-loop/switch region; other site 1232724004991 TOBE domain; Region: TOBE; pfam03459 1232724004992 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1232724004993 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1232724004994 Active Sites [active] 1232724004995 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1232724004996 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232724004997 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232724004998 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1232724004999 HemN C-terminal domain; Region: HemN_C; pfam06969 1232724005000 Predicted permease [General function prediction only]; Region: COG3329 1232724005001 salicylate synthase MbtI; Reviewed; Region: PRK07912 1232724005002 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1232724005003 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1232724005004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232724005005 DNA binding residues [nucleotide binding] 1232724005006 putative dimer interface [polypeptide binding]; other site 1232724005007 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724005008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724005009 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1232724005010 classical (c) SDRs; Region: SDR_c; cd05233 1232724005011 NAD(P) binding site [chemical binding]; other site 1232724005012 active site 1232724005013 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1232724005014 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1232724005015 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724005016 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724005017 lipid-transfer protein; Provisional; Region: PRK07855 1232724005018 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724005019 active site 1232724005020 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1232724005021 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232724005022 NAD binding site [chemical binding]; other site 1232724005023 catalytic Zn binding site [ion binding]; other site 1232724005024 substrate binding site [chemical binding]; other site 1232724005025 structural Zn binding site [ion binding]; other site 1232724005026 short chain dehydrogenase; Provisional; Region: PRK07775 1232724005027 classical (c) SDRs; Region: SDR_c; cd05233 1232724005028 NAD(P) binding site [chemical binding]; other site 1232724005029 active site 1232724005030 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724005031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005033 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005034 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1232724005035 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1232724005036 ligand binding site [chemical binding]; other site 1232724005037 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005038 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724005039 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005040 Cytochrome P450; Region: p450; cl12078 1232724005041 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724005043 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1232724005044 NAD(P) binding site [chemical binding]; other site 1232724005045 active site 1232724005046 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1232724005047 classical (c) SDRs; Region: SDR_c; cd05233 1232724005048 NAD(P) binding site [chemical binding]; other site 1232724005049 active site 1232724005050 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724005051 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005052 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724005053 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005054 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1232724005055 short chain dehydrogenase; Provisional; Region: PRK07814 1232724005056 classical (c) SDRs; Region: SDR_c; cd05233 1232724005057 NAD(P) binding site [chemical binding]; other site 1232724005058 active site 1232724005059 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724005060 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724005061 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724005062 acyl-activating enzyme (AAE) consensus motif; other site 1232724005063 acyl-activating enzyme (AAE) consensus motif; other site 1232724005064 AMP binding site [chemical binding]; other site 1232724005065 active site 1232724005066 CoA binding site [chemical binding]; other site 1232724005067 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724005068 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724005069 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724005070 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005071 Cytochrome P450; Region: p450; cl12078 1232724005072 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724005073 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724005074 NAD(P) binding site [chemical binding]; other site 1232724005075 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724005076 active site 1232724005077 metal binding site [ion binding]; metal-binding site 1232724005078 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1232724005079 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1232724005080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724005081 classical (c) SDRs; Region: SDR_c; cd05233 1232724005082 NAD(P) binding site [chemical binding]; other site 1232724005083 active site 1232724005084 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1232724005085 classical (c) SDRs; Region: SDR_c; cd05233 1232724005086 NAD(P) binding site [chemical binding]; other site 1232724005087 active site 1232724005088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724005089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005091 lipid-transfer protein; Provisional; Region: PRK07855 1232724005092 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724005093 active site 1232724005094 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1232724005095 putative active site [active] 1232724005096 putative catalytic site [active] 1232724005097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005098 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724005099 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724005100 active site 1232724005101 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1232724005102 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724005103 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724005104 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232724005105 active site 1232724005106 catalytic site [active] 1232724005107 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005109 active site 1232724005110 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005111 Cytochrome P450; Region: p450; cl12078 1232724005112 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724005113 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1232724005114 NAD binding site [chemical binding]; other site 1232724005115 catalytic residues [active] 1232724005116 putative CoA-transferase; Provisional; Region: PRK11430 1232724005117 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724005118 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724005119 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724005120 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1232724005121 putative active site [active] 1232724005122 putative catalytic site [active] 1232724005123 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724005124 Isochorismatase family; Region: Isochorismatase; pfam00857 1232724005125 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1232724005126 catalytic triad [active] 1232724005127 conserved cis-peptide bond; other site 1232724005128 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724005129 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724005130 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724005131 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005132 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724005133 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724005134 active site 1232724005135 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724005136 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005137 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724005138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005139 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005140 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005141 active site 1232724005142 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1232724005143 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1232724005144 acyl-activating enzyme (AAE) consensus motif; other site 1232724005145 putative AMP binding site [chemical binding]; other site 1232724005146 putative active site [active] 1232724005147 putative CoA binding site [chemical binding]; other site 1232724005148 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724005149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232724005150 classical (c) SDRs; Region: SDR_c; cd05233 1232724005151 NAD(P) binding site [chemical binding]; other site 1232724005152 active site 1232724005153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724005154 active site 1232724005155 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724005156 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724005157 acyl-activating enzyme (AAE) consensus motif; other site 1232724005158 AMP binding site [chemical binding]; other site 1232724005159 active site 1232724005160 CoA binding site [chemical binding]; other site 1232724005161 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724005162 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724005163 substrate binding site [chemical binding]; other site 1232724005164 oxyanion hole (OAH) forming residues; other site 1232724005165 trimer interface [polypeptide binding]; other site 1232724005166 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724005167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724005168 substrate binding site [chemical binding]; other site 1232724005169 oxyanion hole (OAH) forming residues; other site 1232724005170 trimer interface [polypeptide binding]; other site 1232724005171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005172 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1232724005173 active site 1232724005174 enoyl-CoA hydratase; Provisional; Region: PRK06688 1232724005175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724005176 substrate binding site [chemical binding]; other site 1232724005177 oxyanion hole (OAH) forming residues; other site 1232724005178 trimer interface [polypeptide binding]; other site 1232724005179 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724005180 active site 2 [active] 1232724005181 active site 1 [active] 1232724005182 enoyl-CoA hydratase; Provisional; Region: PRK06688 1232724005183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724005184 substrate binding site [chemical binding]; other site 1232724005185 oxyanion hole (OAH) forming residues; other site 1232724005186 trimer interface [polypeptide binding]; other site 1232724005187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1232724005188 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1232724005189 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1232724005190 NAD binding site [chemical binding]; other site 1232724005191 homodimer interface [polypeptide binding]; other site 1232724005192 active site 1232724005193 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724005194 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724005195 acyl-activating enzyme (AAE) consensus motif; other site 1232724005196 AMP binding site [chemical binding]; other site 1232724005197 active site 1232724005198 CoA binding site [chemical binding]; other site 1232724005199 TniQ; Region: TniQ; pfam06527 1232724005200 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724005201 thiolase; Provisional; Region: PRK06158 1232724005202 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724005203 active site 1232724005204 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1232724005205 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1232724005206 active site 1232724005207 iron coordination sites [ion binding]; other site 1232724005208 substrate binding pocket [chemical binding]; other site 1232724005209 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1232724005210 glycerate dehydrogenase; Provisional; Region: PRK06487 1232724005211 ligand binding site [chemical binding]; other site 1232724005212 NAD binding site [chemical binding]; other site 1232724005213 dimerization interface [polypeptide binding]; other site 1232724005214 catalytic site [active] 1232724005215 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724005216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724005217 substrate binding site [chemical binding]; other site 1232724005218 oxyanion hole (OAH) forming residues; other site 1232724005219 trimer interface [polypeptide binding]; other site 1232724005220 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724005221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005223 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005224 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005225 active site 1232724005226 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724005227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005229 active site 1232724005230 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724005231 CoenzymeA binding site [chemical binding]; other site 1232724005232 subunit interaction site [polypeptide binding]; other site 1232724005233 PHB binding site; other site 1232724005234 enoyl-CoA hydratase; Provisional; Region: PRK08290 1232724005235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724005236 substrate binding site [chemical binding]; other site 1232724005237 oxyanion hole (OAH) forming residues; other site 1232724005238 trimer interface [polypeptide binding]; other site 1232724005239 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005240 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724005241 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1232724005242 FMN binding site [chemical binding]; other site 1232724005243 dimer interface [polypeptide binding]; other site 1232724005244 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005245 Cytochrome P450; Region: p450; cl12078 1232724005246 hypothetical protein; Provisional; Region: PRK07877 1232724005247 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724005248 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724005249 Cupin domain; Region: Cupin_2; cl17218 1232724005250 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1232724005251 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1232724005252 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232724005253 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1232724005254 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1232724005255 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724005256 OsmC-like protein; Region: OsmC; cl00767 1232724005257 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1232724005258 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1232724005259 active site pocket [active] 1232724005260 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1232724005261 aconitate hydratase; Validated; Region: PRK09277 1232724005262 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1232724005263 substrate binding site [chemical binding]; other site 1232724005264 ligand binding site [chemical binding]; other site 1232724005265 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1232724005266 substrate binding site [chemical binding]; other site 1232724005267 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1232724005268 FMN binding site [chemical binding]; other site 1232724005269 dimer interface [polypeptide binding]; other site 1232724005270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724005271 putative DNA binding site [nucleotide binding]; other site 1232724005272 dimerization interface [polypeptide binding]; other site 1232724005273 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232724005274 putative Zn2+ binding site [ion binding]; other site 1232724005275 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1232724005276 heme-binding site [chemical binding]; other site 1232724005277 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1232724005278 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724005279 catalytic loop [active] 1232724005280 iron binding site [ion binding]; other site 1232724005281 Cupin domain; Region: Cupin_2; cl17218 1232724005282 Ferredoxin [Energy production and conversion]; Region: COG1146 1232724005283 4Fe-4S binding domain; Region: Fer4; pfam00037 1232724005284 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1232724005285 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1232724005286 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1232724005287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724005288 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1232724005289 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1232724005290 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1232724005291 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1232724005292 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1232724005293 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1232724005294 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1232724005295 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1232724005296 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1232724005297 Binuclear center (active site) [active] 1232724005298 K-pathway; other site 1232724005299 Putative proton exit pathway; other site 1232724005300 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724005301 Fe binding site [ion binding]; other site 1232724005302 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724005303 PPE family; Region: PPE; pfam00823 1232724005304 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724005305 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232724005306 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232724005307 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232724005308 Condensation domain; Region: Condensation; pfam00668 1232724005309 malate dehydrogenase; Provisional; Region: PRK13529 1232724005310 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1232724005311 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1232724005312 NAD(P) binding site [chemical binding]; other site 1232724005313 Flavodoxin; Region: Flavodoxin_1; pfam00258 1232724005314 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1232724005315 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1232724005316 FAD binding pocket [chemical binding]; other site 1232724005317 FAD binding motif [chemical binding]; other site 1232724005318 catalytic residues [active] 1232724005319 NAD binding pocket [chemical binding]; other site 1232724005320 phosphate binding motif [ion binding]; other site 1232724005321 beta-alpha-beta structure motif; other site 1232724005322 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724005323 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724005324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005325 Cupin domain; Region: Cupin_2; cl17218 1232724005326 short chain dehydrogenase; Provisional; Region: PRK07577 1232724005327 classical (c) SDRs; Region: SDR_c; cd05233 1232724005328 NAD(P) binding site [chemical binding]; other site 1232724005329 active site 1232724005330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232724005331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724005332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1232724005333 dimerization interface [polypeptide binding]; other site 1232724005334 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1232724005335 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1232724005336 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1232724005337 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1232724005338 acyl-activating enzyme (AAE) consensus motif; other site 1232724005339 active site 1232724005340 AMP binding site [chemical binding]; other site 1232724005341 substrate binding site [chemical binding]; other site 1232724005342 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1232724005343 Condensation domain; Region: Condensation; pfam00668 1232724005344 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724005345 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1232724005346 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1232724005347 acyl-activating enzyme (AAE) consensus motif; other site 1232724005348 AMP binding site [chemical binding]; other site 1232724005349 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724005350 Thioesterase domain; Region: Thioesterase; pfam00975 1232724005351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724005352 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1232724005353 active site 1232724005354 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232724005355 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724005356 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1232724005357 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724005358 NADP binding site [chemical binding]; other site 1232724005359 active site 1232724005360 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724005361 Condensation domain; Region: Condensation; pfam00668 1232724005362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724005363 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724005364 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724005365 acyl-activating enzyme (AAE) consensus motif; other site 1232724005366 AMP binding site [chemical binding]; other site 1232724005367 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724005368 Condensation domain; Region: Condensation; pfam00668 1232724005369 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724005370 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724005371 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724005372 acyl-activating enzyme (AAE) consensus motif; other site 1232724005373 AMP binding site [chemical binding]; other site 1232724005374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724005375 Condensation domain; Region: Condensation; pfam00668 1232724005376 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724005377 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724005378 acyl-activating enzyme (AAE) consensus motif; other site 1232724005379 AMP binding site [chemical binding]; other site 1232724005380 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724005381 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1232724005382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724005383 MbtH-like protein; Region: MbtH; pfam03621 1232724005384 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1232724005385 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1232724005386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724005387 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724005388 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724005389 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1232724005390 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1232724005391 HTH domain; Region: HTH_11; cl17392 1232724005392 chaperone protein DnaJ; Provisional; Region: PRK14278 1232724005393 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1232724005394 HSP70 interaction site [polypeptide binding]; other site 1232724005395 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1232724005396 Zn binding sites [ion binding]; other site 1232724005397 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1232724005398 dimer interface [polypeptide binding]; other site 1232724005399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1232724005400 RNA methyltransferase, RsmE family; Region: TIGR00046 1232724005401 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1232724005402 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1232724005403 PhoH-like protein; Region: PhoH; pfam02562 1232724005404 metal-binding heat shock protein; Provisional; Region: PRK00016 1232724005405 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232724005406 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232724005407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232724005408 Transporter associated domain; Region: CorC_HlyC; smart01091 1232724005409 GTPase Era; Reviewed; Region: era; PRK00089 1232724005410 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1232724005411 G1 box; other site 1232724005412 GTP/Mg2+ binding site [chemical binding]; other site 1232724005413 Switch I region; other site 1232724005414 G2 box; other site 1232724005415 Switch II region; other site 1232724005416 G3 box; other site 1232724005417 G4 box; other site 1232724005418 G5 box; other site 1232724005419 KH domain; Region: KH_2; pfam07650 1232724005420 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1232724005421 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724005422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724005423 catalytic residue [active] 1232724005424 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1232724005425 amidase; Provisional; Region: PRK06061 1232724005426 Amidase; Region: Amidase; pfam01425 1232724005427 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1232724005428 Recombination protein O N terminal; Region: RecO_N; pfam11967 1232724005429 Recombination protein O C terminal; Region: RecO_C; pfam02565 1232724005430 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1232724005431 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1232724005432 catalytic residue [active] 1232724005433 putative FPP diphosphate binding site; other site 1232724005434 putative FPP binding hydrophobic cleft; other site 1232724005435 dimer interface [polypeptide binding]; other site 1232724005436 putative IPP diphosphate binding site; other site 1232724005437 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1232724005438 metal binding site 2 [ion binding]; metal-binding site 1232724005439 putative DNA binding helix; other site 1232724005440 metal binding site 1 [ion binding]; metal-binding site 1232724005441 dimer interface [polypeptide binding]; other site 1232724005442 structural Zn2+ binding site [ion binding]; other site 1232724005443 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724005444 dimerization interface [polypeptide binding]; other site 1232724005445 putative DNA binding site [nucleotide binding]; other site 1232724005446 putative Zn2+ binding site [ion binding]; other site 1232724005447 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1232724005448 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232724005449 motif 1; other site 1232724005450 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1232724005451 active site 1232724005452 motif 2; other site 1232724005453 motif 3; other site 1232724005454 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1232724005455 anticodon binding site; other site 1232724005456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724005457 PPE family; Region: PPE; pfam00823 1232724005458 Repair protein; Region: Repair_PSII; pfam04536 1232724005459 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1232724005460 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1232724005461 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1232724005462 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1232724005463 E-class dimer interface [polypeptide binding]; other site 1232724005464 P-class dimer interface [polypeptide binding]; other site 1232724005465 active site 1232724005466 Cu2+ binding site [ion binding]; other site 1232724005467 Zn2+ binding site [ion binding]; other site 1232724005468 DNA primase; Validated; Region: dnaG; PRK05667 1232724005469 CHC2 zinc finger; Region: zf-CHC2; cl17510 1232724005470 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1232724005471 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1232724005472 active site 1232724005473 metal binding site [ion binding]; metal-binding site 1232724005474 interdomain interaction site; other site 1232724005475 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1232724005476 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1232724005477 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1232724005478 active site 1232724005479 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1232724005480 non-prolyl cis peptide bond; other site 1232724005481 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1232724005482 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724005483 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724005484 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724005485 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1232724005486 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1232724005487 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1232724005488 trimer interface [polypeptide binding]; other site 1232724005489 active site 1232724005490 substrate binding site [chemical binding]; other site 1232724005491 CoA binding site [chemical binding]; other site 1232724005492 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232724005493 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232724005494 dimer interface [polypeptide binding]; other site 1232724005495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724005496 catalytic residue [active] 1232724005497 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1232724005498 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1232724005499 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1232724005500 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1232724005501 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1232724005502 [4Fe-4S] binding site [ion binding]; other site 1232724005503 molybdopterin cofactor binding site; other site 1232724005504 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1232724005505 molybdopterin cofactor binding site; other site 1232724005506 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1232724005507 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1232724005508 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1232724005509 FAD binding pocket [chemical binding]; other site 1232724005510 FAD binding motif [chemical binding]; other site 1232724005511 catalytic residues [active] 1232724005512 NAD binding pocket [chemical binding]; other site 1232724005513 phosphate binding motif [ion binding]; other site 1232724005514 beta-alpha-beta structure motif; other site 1232724005515 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1232724005516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005517 active site 1232724005518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724005519 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1232724005520 Walker A/P-loop; other site 1232724005521 ATP binding site [chemical binding]; other site 1232724005522 Q-loop/lid; other site 1232724005523 ABC transporter signature motif; other site 1232724005524 Walker B; other site 1232724005525 D-loop; other site 1232724005526 H-loop/switch region; other site 1232724005527 MarR family; Region: MarR; pfam01047 1232724005528 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724005529 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 1232724005530 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644 1232724005531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1232724005532 Walker A/P-loop; other site 1232724005533 ATP binding site [chemical binding]; other site 1232724005534 Q-loop/lid; other site 1232724005535 ABC transporter signature motif; other site 1232724005536 Walker B; other site 1232724005537 D-loop; other site 1232724005538 H-loop/switch region; other site 1232724005539 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232724005540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1232724005541 Walker A/P-loop; other site 1232724005542 ATP binding site [chemical binding]; other site 1232724005543 Q-loop/lid; other site 1232724005544 ABC transporter signature motif; other site 1232724005545 Walker B; other site 1232724005546 D-loop; other site 1232724005547 H-loop/switch region; other site 1232724005548 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1232724005549 amino acid transporter; Region: 2A0306; TIGR00909 1232724005550 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1232724005551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1232724005552 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1232724005553 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1232724005554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724005555 dimer interface [polypeptide binding]; other site 1232724005556 conserved gate region; other site 1232724005557 putative PBP binding loops; other site 1232724005558 ABC-ATPase subunit interface; other site 1232724005559 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1232724005560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724005561 dimer interface [polypeptide binding]; other site 1232724005562 conserved gate region; other site 1232724005563 putative PBP binding loops; other site 1232724005564 ABC-ATPase subunit interface; other site 1232724005565 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1232724005566 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1232724005567 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724005568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724005569 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724005570 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724005571 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1232724005572 catalytic site [active] 1232724005573 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1232724005574 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1232724005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724005576 ABC transporter signature motif; other site 1232724005577 Walker B; other site 1232724005578 D-loop; other site 1232724005579 H-loop/switch region; other site 1232724005580 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1232724005581 frameshift; aldehyde dehydrogenase 1232724005582 Repair protein; Region: Repair_PSII; pfam04536 1232724005583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1232724005584 AAA domain; Region: AAA_33; pfam13671 1232724005585 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1232724005586 active site 1232724005587 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1232724005588 catalytic triad [active] 1232724005589 active site nucleophile [active] 1232724005590 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1232724005591 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1232724005592 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724005593 cyclase homology domain; Region: CHD; cd07302 1232724005594 nucleotidyl binding site; other site 1232724005595 metal binding site [ion binding]; metal-binding site 1232724005596 dimer interface [polypeptide binding]; other site 1232724005597 AAA ATPase domain; Region: AAA_16; pfam13191 1232724005598 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1232724005599 GAF domain; Region: GAF; pfam01590 1232724005600 GAF domain; Region: GAF_3; pfam13492 1232724005601 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1232724005602 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1232724005603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1232724005604 ATP binding site [chemical binding]; other site 1232724005605 Mg2+ binding site [ion binding]; other site 1232724005606 G-X-G motif; other site 1232724005607 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724005608 anti sigma factor interaction site; other site 1232724005609 regulatory phosphorylation site [posttranslational modification]; other site 1232724005610 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724005611 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724005612 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724005613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724005614 S-adenosylmethionine binding site [chemical binding]; other site 1232724005615 CCC1-related family of proteins; Region: CCC1_like; cl00278 1232724005616 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1232724005617 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724005618 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1232724005619 acyl-activating enzyme (AAE) consensus motif; other site 1232724005620 putative AMP binding site [chemical binding]; other site 1232724005621 putative active site [active] 1232724005622 putative CoA binding site [chemical binding]; other site 1232724005623 TIGR03085 family protein; Region: TIGR03085 1232724005624 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724005625 heat shock protein 90; Provisional; Region: PRK05218 1232724005626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724005627 ATP binding site [chemical binding]; other site 1232724005628 Mg2+ binding site [ion binding]; other site 1232724005629 G-X-G motif; other site 1232724005630 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724005631 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724005632 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724005633 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1232724005634 dimer interface [polypeptide binding]; other site 1232724005635 ligand binding site [chemical binding]; other site 1232724005636 Predicted membrane protein [Function unknown]; Region: COG4270 1232724005637 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1232724005638 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232724005639 NAD binding site [chemical binding]; other site 1232724005640 catalytic Zn binding site [ion binding]; other site 1232724005641 substrate binding site [chemical binding]; other site 1232724005642 structural Zn binding site [ion binding]; other site 1232724005643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724005644 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1232724005645 dimer interface [polypeptide binding]; other site 1232724005646 active site 1232724005647 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232724005648 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1232724005649 active site 1232724005650 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1232724005651 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1232724005652 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1232724005653 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1232724005654 DoxX-like family; Region: DoxX_2; pfam13564 1232724005655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724005656 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232724005657 NAD(P) binding site [chemical binding]; other site 1232724005658 active site 1232724005659 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232724005660 MarR family; Region: MarR; pfam01047 1232724005661 haloalkane dehalogenase; Provisional; Region: PRK00870 1232724005662 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1232724005663 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1232724005664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724005665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724005666 homodimer interface [polypeptide binding]; other site 1232724005667 catalytic residue [active] 1232724005668 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005669 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724005670 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005671 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724005672 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724005673 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1232724005674 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1232724005675 ligand binding site [chemical binding]; other site 1232724005676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005678 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005679 Cytochrome P450; Region: p450; cl12078 1232724005680 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724005681 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724005682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724005683 dimerization interface [polypeptide binding]; other site 1232724005684 putative DNA binding site [nucleotide binding]; other site 1232724005685 putative Zn2+ binding site [ion binding]; other site 1232724005686 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1232724005687 arsenical-resistance protein; Region: acr3; TIGR00832 1232724005688 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1232724005689 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1232724005690 active site 1232724005691 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1232724005692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724005693 putative metal binding site [ion binding]; other site 1232724005694 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724005695 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724005696 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724005697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005698 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232724005699 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005700 Cytochrome P450; Region: p450; cl12078 1232724005701 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1232724005702 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1232724005703 active site residue [active] 1232724005704 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1232724005705 active site residue [active] 1232724005706 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724005707 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1232724005708 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232724005709 hypothetical protein; Provisional; Region: PRK08244 1232724005710 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724005711 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724005712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005713 Predicted ATPase [General function prediction only]; Region: COG4637 1232724005714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724005715 Walker A/P-loop; other site 1232724005716 ATP binding site [chemical binding]; other site 1232724005717 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1232724005718 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1232724005719 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1232724005720 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724005721 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724005722 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1232724005723 4Fe-4S binding domain; Region: Fer4; cl02805 1232724005724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232724005725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724005726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232724005727 dimerization interface [polypeptide binding]; other site 1232724005728 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1232724005729 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1232724005730 putative active site [active] 1232724005731 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1232724005732 putative active site [active] 1232724005733 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1232724005734 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232724005735 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232724005736 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1232724005737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724005738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724005739 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005740 Cytochrome P450; Region: p450; cl12078 1232724005741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005745 Domain of unknown function (DUF385); Region: DUF385; cl04387 1232724005746 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724005747 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1232724005748 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724005749 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1232724005750 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724005751 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724005752 active site 1232724005753 ATP binding site [chemical binding]; other site 1232724005754 substrate binding site [chemical binding]; other site 1232724005755 activation loop (A-loop); other site 1232724005756 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1232724005757 2TM domain; Region: 2TM; pfam13239 1232724005758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005760 WHG domain; Region: WHG; pfam13305 1232724005761 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005762 Cytochrome P450; Region: p450; cl12078 1232724005763 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724005764 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1232724005765 active site 1232724005766 metal binding site [ion binding]; metal-binding site 1232724005767 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1232724005768 oligomeric interface; other site 1232724005769 putative active site [active] 1232724005770 homodimer interface [polypeptide binding]; other site 1232724005771 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 1232724005772 PLD-like domain; Region: PLDc_2; pfam13091 1232724005773 putative homodimer interface [polypeptide binding]; other site 1232724005774 putative active site [active] 1232724005775 catalytic site [active] 1232724005776 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232724005777 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1232724005778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724005779 nucleotide binding region [chemical binding]; other site 1232724005780 ATP-binding site [chemical binding]; other site 1232724005781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724005782 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232724005783 Integrase core domain; Region: rve; pfam00665 1232724005784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724005785 Walker A motif; other site 1232724005786 ATP binding site [chemical binding]; other site 1232724005787 Walker B motif; other site 1232724005788 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1232724005789 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724005790 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724005791 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724005792 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724005793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724005796 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724005797 active site 1232724005798 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1232724005799 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1232724005800 active site 1232724005801 metal binding site [ion binding]; metal-binding site 1232724005802 Cutinase; Region: Cutinase; pfam01083 1232724005803 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724005804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724005805 Septum formation; Region: Septum_form; pfam13845 1232724005806 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724005807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724005808 Cytochrome P450; Region: p450; cl12078 1232724005809 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724005810 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724005811 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724005812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724005813 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1232724005814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724005815 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1232724005816 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232724005817 NAD binding site [chemical binding]; other site 1232724005818 catalytic Zn binding site [ion binding]; other site 1232724005819 substrate binding site [chemical binding]; other site 1232724005820 structural Zn binding site [ion binding]; other site 1232724005821 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724005822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724005823 S-adenosylmethionine binding site [chemical binding]; other site 1232724005824 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724005825 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724005826 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1232724005827 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724005828 diacylglycerol kinase; Reviewed; Region: PRK11914 1232724005829 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1232724005830 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232724005831 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724005832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724005833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724005834 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1232724005835 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1232724005836 nucleoside/Zn binding site; other site 1232724005837 dimer interface [polypeptide binding]; other site 1232724005838 catalytic motif [active] 1232724005839 hypothetical protein; Provisional; Region: PRK06126 1232724005840 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724005841 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724005842 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232724005843 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232724005844 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724005845 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1232724005846 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1232724005847 dimer interface [polypeptide binding]; other site 1232724005848 active site 1232724005849 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1232724005850 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1232724005851 dimer interface [polypeptide binding]; other site 1232724005852 active site 1232724005853 acyl carrier protein; Provisional; Region: acpP; PRK00982 1232724005854 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232724005855 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232724005856 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1232724005857 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1232724005858 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1232724005859 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1232724005860 dimer interface [polypeptide binding]; other site 1232724005861 TPP-binding site [chemical binding]; other site 1232724005862 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1232724005863 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1232724005864 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1232724005865 dimer interface [polypeptide binding]; other site 1232724005866 catalytic triad [active] 1232724005867 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1232724005868 Int/Topo IB signature motif; other site 1232724005869 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1232724005870 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1232724005871 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724005872 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232724005873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724005874 active site 1232724005875 metal binding site [ion binding]; metal-binding site 1232724005876 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1232724005877 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1232724005878 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1232724005879 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1232724005880 active site 1232724005881 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1232724005882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724005883 motif II; other site 1232724005884 hypothetical protein; Provisional; Region: PRK07908 1232724005885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724005886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724005887 catalytic residue [active] 1232724005888 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1232724005889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1232724005890 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1232724005891 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1232724005892 Putative zinc ribbon domain; Region: DUF164; pfam02591 1232724005893 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1232724005894 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1232724005895 RNA/DNA hybrid binding site [nucleotide binding]; other site 1232724005896 active site 1232724005897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724005898 catalytic core [active] 1232724005899 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1232724005900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724005901 Helix-turn-helix domain; Region: HTH_18; pfam12833 1232724005902 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724005903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724005904 sequence-specific DNA binding site [nucleotide binding]; other site 1232724005905 salt bridge; other site 1232724005906 Cupin domain; Region: Cupin_2; pfam07883 1232724005907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724005908 S-adenosylmethionine binding site [chemical binding]; other site 1232724005909 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1232724005910 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1232724005911 putative active site; other site 1232724005912 putative metal binding residues [ion binding]; other site 1232724005913 signature motif; other site 1232724005914 putative triphosphate binding site [ion binding]; other site 1232724005915 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1232724005916 hypothetical protein; Provisional; Region: PRK06185 1232724005917 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1232724005918 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1232724005919 oligomerization interface [polypeptide binding]; other site 1232724005920 active site 1232724005921 metal binding site [ion binding]; metal-binding site 1232724005922 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1232724005923 TAP-like protein; Region: Abhydrolase_4; pfam08386 1232724005924 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1232724005925 TAP-like protein; Region: Abhydrolase_4; pfam08386 1232724005926 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1232724005927 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1232724005928 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1232724005929 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1232724005930 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1232724005931 metal binding triad; other site 1232724005932 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1232724005933 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1232724005934 metal binding triad; other site 1232724005935 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1232724005936 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724005937 CoenzymeA binding site [chemical binding]; other site 1232724005938 subunit interaction site [polypeptide binding]; other site 1232724005939 PHB binding site; other site 1232724005940 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724005941 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724005942 MarR family; Region: MarR_2; pfam12802 1232724005943 frameshift; Flavin reductase 1232724005944 glutamine synthetase, type I; Region: GlnA; TIGR00653 1232724005945 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1232724005946 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1232724005947 RDD family; Region: RDD; pfam06271 1232724005948 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1232724005949 lipoyl synthase; Provisional; Region: PRK05481 1232724005950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724005951 FeS/SAM binding site; other site 1232724005952 lipoate-protein ligase B; Provisional; Region: PRK14345 1232724005953 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1232724005954 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1232724005955 putative NAD(P) binding site [chemical binding]; other site 1232724005956 putative active site [active] 1232724005957 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232724005958 E3 interaction surface; other site 1232724005959 lipoyl attachment site [posttranslational modification]; other site 1232724005960 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232724005961 E3 interaction surface; other site 1232724005962 lipoyl attachment site [posttranslational modification]; other site 1232724005963 e3 binding domain; Region: E3_binding; pfam02817 1232724005964 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1232724005965 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232724005966 short chain dehydrogenase; Validated; Region: PRK05855 1232724005967 classical (c) SDRs; Region: SDR_c; cd05233 1232724005968 NAD(P) binding site [chemical binding]; other site 1232724005969 active site 1232724005970 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724005971 hydrophobic ligand binding site; other site 1232724005972 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724005973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724005974 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1232724005975 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1232724005976 interface (dimer of trimers) [polypeptide binding]; other site 1232724005977 Substrate-binding/catalytic site; other site 1232724005978 Zn-binding sites [ion binding]; other site 1232724005979 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1232724005980 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1232724005981 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1232724005982 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1232724005983 homodimer interface [polypeptide binding]; other site 1232724005984 substrate-cofactor binding pocket; other site 1232724005985 catalytic residue [active] 1232724005986 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1232724005987 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1232724005988 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1232724005989 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1232724005990 putative dimer interface [polypeptide binding]; other site 1232724005991 active site pocket [active] 1232724005992 putative cataytic base [active] 1232724005993 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1232724005994 homotrimer interface [polypeptide binding]; other site 1232724005995 Walker A motif; other site 1232724005996 GTP binding site [chemical binding]; other site 1232724005997 Walker B motif; other site 1232724005998 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1232724005999 Glycerate kinase family; Region: Gly_kinase; pfam02595 1232724006000 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1232724006001 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1232724006002 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232724006003 substrate binding site [chemical binding]; other site 1232724006004 ATP binding site [chemical binding]; other site 1232724006005 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1232724006006 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1232724006007 active site 1232724006008 dimer interface [polypeptide binding]; other site 1232724006009 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1232724006010 Ligand Binding Site [chemical binding]; other site 1232724006011 Molecular Tunnel; other site 1232724006012 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1232724006013 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1232724006014 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1232724006015 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724006016 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1232724006017 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1232724006018 heme bH binding site [chemical binding]; other site 1232724006019 intrachain domain interface; other site 1232724006020 heme bL binding site [chemical binding]; other site 1232724006021 interchain domain interface [polypeptide binding]; other site 1232724006022 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1232724006023 Qo binding site; other site 1232724006024 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1232724006025 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1232724006026 iron-sulfur cluster [ion binding]; other site 1232724006027 [2Fe-2S] cluster binding site [ion binding]; other site 1232724006028 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1232724006029 Cytochrome c; Region: Cytochrom_C; pfam00034 1232724006030 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1232724006031 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1232724006032 Subunit I/III interface [polypeptide binding]; other site 1232724006033 hypothetical protein; Validated; Region: PRK07883 1232724006034 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1232724006035 active site 1232724006036 catalytic site [active] 1232724006037 substrate binding site [chemical binding]; other site 1232724006038 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1232724006039 GIY-YIG motif/motif A; other site 1232724006040 active site 1232724006041 catalytic site [active] 1232724006042 putative DNA binding site [nucleotide binding]; other site 1232724006043 metal binding site [ion binding]; metal-binding site 1232724006044 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232724006045 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232724006046 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1232724006047 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724006048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724006049 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1232724006050 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1232724006051 acyl-activating enzyme (AAE) consensus motif; other site 1232724006052 putative AMP binding site [chemical binding]; other site 1232724006053 putative active site [active] 1232724006054 putative CoA binding site [chemical binding]; other site 1232724006055 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1232724006056 putative hydrophobic ligand binding site [chemical binding]; other site 1232724006057 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1232724006058 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1232724006059 DTAP/Switch II; other site 1232724006060 Switch I; other site 1232724006061 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724006062 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232724006063 putative acyl-acceptor binding pocket; other site 1232724006064 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1232724006065 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1232724006066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724006067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724006068 active site 1232724006069 ATP binding site [chemical binding]; other site 1232724006070 substrate binding site [chemical binding]; other site 1232724006071 activation loop (A-loop); other site 1232724006072 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1232724006073 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232724006074 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232724006075 substrate binding pocket [chemical binding]; other site 1232724006076 chain length determination region; other site 1232724006077 substrate-Mg2+ binding site; other site 1232724006078 catalytic residues [active] 1232724006079 aspartate-rich region 1; other site 1232724006080 active site lid residues [active] 1232724006081 aspartate-rich region 2; other site 1232724006082 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1232724006083 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1232724006084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1232724006085 MraZ protein; Region: MraZ; pfam02381 1232724006086 MraZ protein; Region: MraZ; pfam02381 1232724006087 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1232724006088 MraW methylase family; Region: Methyltransf_5; cl17771 1232724006089 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1232724006090 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1232724006091 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232724006092 hypothetical protein; Provisional; Region: PRK07236 1232724006093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724006094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006095 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1232724006096 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232724006097 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232724006098 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232724006099 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1232724006100 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232724006101 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232724006102 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1232724006103 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1232724006104 Mg++ binding site [ion binding]; other site 1232724006105 putative catalytic motif [active] 1232724006106 putative substrate binding site [chemical binding]; other site 1232724006107 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1232724006108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232724006109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232724006110 cell division protein FtsW; Region: ftsW; TIGR02614 1232724006111 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1232724006112 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1232724006113 active site 1232724006114 homodimer interface [polypeptide binding]; other site 1232724006115 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1232724006116 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232724006117 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232724006118 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232724006119 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1232724006120 Cell division protein FtsQ; Region: FtsQ; pfam03799 1232724006121 cell division protein FtsZ; Validated; Region: PRK09330 1232724006122 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1232724006123 nucleotide binding site [chemical binding]; other site 1232724006124 SulA interaction site; other site 1232724006125 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1232724006126 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1232724006127 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1232724006128 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232724006129 catalytic residue [active] 1232724006130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1232724006131 Predicted integral membrane protein [Function unknown]; Region: COG0762 1232724006132 DivIVA domain; Region: DivI1A_domain; TIGR03544 1232724006133 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1232724006134 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1232724006135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232724006136 active site 1232724006137 hypothetical protein; Provisional; Region: PRK07906 1232724006138 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1232724006139 putative metal binding site [ion binding]; other site 1232724006140 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1232724006141 substrate binding site [chemical binding]; other site 1232724006142 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1232724006143 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1232724006144 quinone interaction residues [chemical binding]; other site 1232724006145 active site 1232724006146 catalytic residues [active] 1232724006147 FMN binding site [chemical binding]; other site 1232724006148 substrate binding site [chemical binding]; other site 1232724006149 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724006150 catalytic core [active] 1232724006151 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1232724006152 conserved hypothetical protein; Region: TIGR03843 1232724006153 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1232724006154 active site 1232724006155 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1232724006156 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724006157 active site 1232724006158 HIGH motif; other site 1232724006159 nucleotide binding site [chemical binding]; other site 1232724006160 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724006161 active site 1232724006162 KMSKS motif; other site 1232724006163 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1232724006164 putative tRNA binding surface [nucleotide binding]; other site 1232724006165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724006166 Walker A/P-loop; other site 1232724006167 ATP binding site [chemical binding]; other site 1232724006168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724006169 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724006170 DNA binding residues [nucleotide binding] 1232724006171 dimerization interface [polypeptide binding]; other site 1232724006172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724006173 Walker A/P-loop; other site 1232724006174 ATP binding site [chemical binding]; other site 1232724006175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724006176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724006177 DNA binding residues [nucleotide binding] 1232724006178 dimerization interface [polypeptide binding]; other site 1232724006179 MbtH-like protein; Region: MbtH; pfam03621 1232724006180 Condensation domain; Region: Condensation; pfam00668 1232724006181 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724006182 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724006183 acyl-activating enzyme (AAE) consensus motif; other site 1232724006184 AMP binding site [chemical binding]; other site 1232724006185 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724006186 Condensation domain; Region: Condensation; pfam00668 1232724006187 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724006188 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724006189 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724006190 acyl-activating enzyme (AAE) consensus motif; other site 1232724006191 AMP binding site [chemical binding]; other site 1232724006192 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724006193 Condensation domain; Region: Condensation; pfam00668 1232724006194 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724006195 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724006196 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724006197 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724006198 acyl-activating enzyme (AAE) consensus motif; other site 1232724006199 AMP binding site [chemical binding]; other site 1232724006200 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232724006201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724006202 S-adenosylmethionine binding site [chemical binding]; other site 1232724006203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724006204 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724006205 Condensation domain; Region: Condensation; pfam00668 1232724006206 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724006207 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724006208 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724006209 acyl-activating enzyme (AAE) consensus motif; other site 1232724006210 AMP binding site [chemical binding]; other site 1232724006211 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724006212 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1232724006213 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724006214 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724006215 acyl-activating enzyme (AAE) consensus motif; other site 1232724006216 AMP binding site [chemical binding]; other site 1232724006217 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724006218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724006219 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1232724006220 putative substrate translocation pore; other site 1232724006221 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232724006222 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724006223 active site 1232724006224 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1232724006225 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1232724006226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006227 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1232724006228 Enoylreductase; Region: PKS_ER; smart00829 1232724006229 NAD(P) binding site [chemical binding]; other site 1232724006230 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1232724006231 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724006232 putative NADP binding site [chemical binding]; other site 1232724006233 active site 1232724006234 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724006235 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724006236 Cytochrome P450; Region: p450; cl12078 1232724006237 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1232724006238 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1232724006239 FAD binding pocket [chemical binding]; other site 1232724006240 FAD binding motif [chemical binding]; other site 1232724006241 phosphate binding motif [ion binding]; other site 1232724006242 NAD binding pocket [chemical binding]; other site 1232724006243 acyl-CoA synthetase; Validated; Region: PRK05850 1232724006244 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1232724006245 acyl-activating enzyme (AAE) consensus motif; other site 1232724006246 active site 1232724006247 short chain dehydrogenase; Provisional; Region: PRK05872 1232724006248 classical (c) SDRs; Region: SDR_c; cd05233 1232724006249 NAD(P) binding site [chemical binding]; other site 1232724006250 active site 1232724006251 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1232724006252 PAC2 family; Region: PAC2; pfam09754 1232724006253 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1232724006254 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1232724006255 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1232724006256 substrate binding pocket [chemical binding]; other site 1232724006257 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1232724006258 B12 binding site [chemical binding]; other site 1232724006259 cobalt ligand [ion binding]; other site 1232724006260 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1232724006261 Mannan-binding protein; Region: MVL; pfam12151 1232724006262 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1232724006263 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724006264 mce related protein; Region: MCE; pfam02470 1232724006265 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724006266 mce related protein; Region: MCE; pfam02470 1232724006267 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724006268 mce related protein; Region: MCE; pfam02470 1232724006269 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232724006270 mce related protein; Region: MCE; pfam02470 1232724006271 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232724006272 mce related protein; Region: MCE; pfam02470 1232724006273 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232724006274 mce related protein; Region: MCE; pfam02470 1232724006275 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724006276 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724006277 Permease; Region: Permease; pfam02405 1232724006278 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724006279 Permease; Region: Permease; pfam02405 1232724006280 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724006281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006282 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1232724006283 homodimer interface [polypeptide binding]; other site 1232724006284 putative metal binding site [ion binding]; other site 1232724006285 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1232724006286 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1232724006287 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1232724006288 Predicted membrane protein [Function unknown]; Region: COG3918 1232724006289 mercuric reductase; Validated; Region: PRK06370 1232724006290 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724006291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724006292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724006293 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1232724006294 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1232724006295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724006296 S-adenosylmethionine binding site [chemical binding]; other site 1232724006297 Protein of unknown function (DUF503); Region: DUF503; cl00669 1232724006298 proteasome ATPase; Region: pup_AAA; TIGR03689 1232724006299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724006300 Walker A motif; other site 1232724006301 ATP binding site [chemical binding]; other site 1232724006302 Walker B motif; other site 1232724006303 arginine finger; other site 1232724006304 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1232724006305 Pup-like protein; Region: Pup; cl05289 1232724006306 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1232724006307 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1232724006308 active site 1232724006309 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1232724006310 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1232724006311 active site 1232724006312 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1232724006313 Predicted transcriptional regulator [Transcription]; Region: COG2378 1232724006314 WYL domain; Region: WYL; pfam13280 1232724006315 Predicted transcriptional regulator [Transcription]; Region: COG2378 1232724006316 WYL domain; Region: WYL; pfam13280 1232724006317 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1232724006318 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1232724006319 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1232724006320 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1232724006321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724006322 ATP binding site [chemical binding]; other site 1232724006323 putative Mg++ binding site [ion binding]; other site 1232724006324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724006325 nucleotide binding region [chemical binding]; other site 1232724006326 ATP-binding site [chemical binding]; other site 1232724006327 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1232724006328 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1232724006329 5'-3' exonuclease; Region: 53EXOc; smart00475 1232724006330 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1232724006331 active site 1232724006332 metal binding site 1 [ion binding]; metal-binding site 1232724006333 putative 5' ssDNA interaction site; other site 1232724006334 metal binding site 3; metal-binding site 1232724006335 metal binding site 2 [ion binding]; metal-binding site 1232724006336 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1232724006337 putative DNA binding site [nucleotide binding]; other site 1232724006338 putative metal binding site [ion binding]; other site 1232724006339 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232724006340 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1232724006341 active site 1232724006342 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1232724006343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006344 NAD(P) binding site [chemical binding]; other site 1232724006345 active site 1232724006346 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1232724006347 active site 1232724006348 putative homodimer interface [polypeptide binding]; other site 1232724006349 SAM binding site [chemical binding]; other site 1232724006350 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1232724006351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724006352 S-adenosylmethionine binding site [chemical binding]; other site 1232724006353 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1232724006354 active site 1232724006355 SAM binding site [chemical binding]; other site 1232724006356 homodimer interface [polypeptide binding]; other site 1232724006357 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1232724006358 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1232724006359 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 1232724006360 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1232724006361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724006362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724006363 DNA binding residues [nucleotide binding] 1232724006364 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724006365 PPE family; Region: PPE; pfam00823 1232724006366 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1232724006367 active site 1232724006368 SAM binding site [chemical binding]; other site 1232724006369 homodimer interface [polypeptide binding]; other site 1232724006370 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1232724006371 active site 1232724006372 SAM binding site [chemical binding]; other site 1232724006373 homodimer interface [polypeptide binding]; other site 1232724006374 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1232724006375 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1232724006376 precorrin-3B synthase; Region: CobG; TIGR02435 1232724006377 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232724006378 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1232724006379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724006380 dimer interface [polypeptide binding]; other site 1232724006381 conserved gate region; other site 1232724006382 putative PBP binding loops; other site 1232724006383 ABC-ATPase subunit interface; other site 1232724006384 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1232724006385 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1232724006386 Walker A/P-loop; other site 1232724006387 ATP binding site [chemical binding]; other site 1232724006388 Q-loop/lid; other site 1232724006389 ABC transporter signature motif; other site 1232724006390 Walker B; other site 1232724006391 D-loop; other site 1232724006392 H-loop/switch region; other site 1232724006393 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1232724006394 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724006395 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1232724006396 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1232724006397 Moco binding site; other site 1232724006398 metal coordination site [ion binding]; other site 1232724006399 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1232724006400 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1232724006401 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1232724006402 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1232724006403 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1232724006404 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1232724006405 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1232724006406 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1232724006407 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1232724006408 active site 1232724006409 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1232724006410 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1232724006411 putative active site [active] 1232724006412 catalytic triad [active] 1232724006413 putative dimer interface [polypeptide binding]; other site 1232724006414 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1232724006415 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1232724006416 Ligand binding site; other site 1232724006417 Putative Catalytic site; other site 1232724006418 DXD motif; other site 1232724006419 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1232724006420 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232724006421 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724006422 active site 1232724006423 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724006424 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1232724006425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006426 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1232724006427 Enoylreductase; Region: PKS_ER; smart00829 1232724006428 NAD(P) binding site [chemical binding]; other site 1232724006429 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1232724006430 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724006431 putative NADP binding site [chemical binding]; other site 1232724006432 active site 1232724006433 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724006434 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232724006435 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724006436 active site 1232724006437 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724006438 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1232724006439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006440 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1232724006441 Enoylreductase; Region: PKS_ER; smart00829 1232724006442 NAD(P) binding site [chemical binding]; other site 1232724006443 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1232724006444 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724006445 putative NADP binding site [chemical binding]; other site 1232724006446 active site 1232724006447 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724006448 hypothetical protein; Provisional; Region: PRK05865 1232724006449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006450 NAD(P) binding site [chemical binding]; other site 1232724006451 active site 1232724006452 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232724006453 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724006454 Cytochrome P450; Region: p450; cl12078 1232724006455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006456 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1232724006457 NAD(P) binding site [chemical binding]; other site 1232724006458 active site 1232724006459 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724006460 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724006461 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1232724006462 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1232724006463 Walker A motif; other site 1232724006464 ATP binding site [chemical binding]; other site 1232724006465 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1232724006466 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1232724006467 metal ion-dependent adhesion site (MIDAS); other site 1232724006468 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724006469 short chain dehydrogenase; Provisional; Region: PRK07814 1232724006470 classical (c) SDRs; Region: SDR_c; cd05233 1232724006471 NAD(P) binding site [chemical binding]; other site 1232724006472 active site 1232724006473 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724006474 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724006475 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724006476 classical (c) SDRs; Region: SDR_c; cd05233 1232724006477 NAD(P) binding site [chemical binding]; other site 1232724006478 active site 1232724006479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724006480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006481 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724006482 Cytochrome P450; Region: p450; cl12078 1232724006483 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1232724006484 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724006485 substrate binding pocket [chemical binding]; other site 1232724006486 catalytic triad [active] 1232724006487 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724006488 Ecdysteroid kinase; Region: EcKinase; cl17738 1232724006489 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1232724006490 ATP-binding site [chemical binding]; other site 1232724006491 Gluconate-6-phosphate binding site [chemical binding]; other site 1232724006492 Shikimate kinase; Region: SKI; pfam01202 1232724006493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724006494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006495 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724006496 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724006497 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1232724006498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1232724006499 AAA domain; Region: AAA_33; pfam13671 1232724006500 Predicted membrane protein [Function unknown]; Region: COG2259 1232724006501 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1232724006502 catalytic triad [active] 1232724006503 conserved cis-peptide bond; other site 1232724006504 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1232724006505 DoxX-like family; Region: DoxX_2; pfam13564 1232724006506 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1232724006507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724006508 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1232724006509 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1232724006510 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1232724006511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724006512 dimer interface [polypeptide binding]; other site 1232724006513 conserved gate region; other site 1232724006514 putative PBP binding loops; other site 1232724006515 ABC-ATPase subunit interface; other site 1232724006516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1232724006517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724006518 dimer interface [polypeptide binding]; other site 1232724006519 conserved gate region; other site 1232724006520 putative PBP binding loops; other site 1232724006521 ABC-ATPase subunit interface; other site 1232724006522 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1232724006523 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1232724006524 Walker A/P-loop; other site 1232724006525 ATP binding site [chemical binding]; other site 1232724006526 Q-loop/lid; other site 1232724006527 ABC transporter signature motif; other site 1232724006528 Walker B; other site 1232724006529 D-loop; other site 1232724006530 H-loop/switch region; other site 1232724006531 TOBE domain; Region: TOBE_2; pfam08402 1232724006532 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1232724006533 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1232724006534 nucleophile elbow; other site 1232724006535 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1232724006536 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1232724006537 Iron permease FTR1 family; Region: FTR1; cl00475 1232724006538 Imelysin; Region: Peptidase_M75; pfam09375 1232724006539 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1232724006540 OsmC-like protein; Region: OsmC; pfam02566 1232724006541 cyanate hydratase; Validated; Region: PRK02866 1232724006542 Helix-turn-helix domain; Region: HTH_19; pfam12844 1232724006543 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1232724006544 oligomer interface [polypeptide binding]; other site 1232724006545 active site 1232724006546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006547 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006548 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 1232724006549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724006550 DNA binding residues [nucleotide binding] 1232724006551 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1232724006552 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1232724006553 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724006554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724006555 active site 1232724006556 catalytic tetrad [active] 1232724006557 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1232724006558 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1232724006559 putative NADP binding site [chemical binding]; other site 1232724006560 putative substrate binding site [chemical binding]; other site 1232724006561 active site 1232724006562 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232724006563 extended (e) SDRs; Region: SDR_e; cd08946 1232724006564 NAD(P) binding site [chemical binding]; other site 1232724006565 active site 1232724006566 substrate binding site [chemical binding]; other site 1232724006567 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724006568 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1232724006569 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724006570 active site 2 [active] 1232724006571 active site 1 [active] 1232724006572 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1232724006573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006574 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006575 active site 1232724006576 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1232724006577 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724006578 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1232724006579 homotetramer interface [polypeptide binding]; other site 1232724006580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724006581 NAD binding site [chemical binding]; other site 1232724006582 homodimer interface [polypeptide binding]; other site 1232724006583 active site 1232724006584 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1232724006585 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724006586 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724006587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006588 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724006589 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724006590 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724006591 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724006592 substrate binding site [chemical binding]; other site 1232724006593 oxyanion hole (OAH) forming residues; other site 1232724006594 trimer interface [polypeptide binding]; other site 1232724006595 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1232724006596 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1232724006597 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1232724006598 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1232724006599 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1232724006600 active site 1232724006601 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1232724006602 catalytic triad [active] 1232724006603 dimer interface [polypeptide binding]; other site 1232724006604 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1232724006605 ABC1 family; Region: ABC1; pfam03109 1232724006606 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1232724006607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724006608 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1232724006609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724006610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006611 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1232724006612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724006613 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1232724006614 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1232724006615 active site 1232724006616 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724006617 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1232724006618 active site 1232724006619 substrate binding site [chemical binding]; other site 1232724006620 ATP binding site [chemical binding]; other site 1232724006621 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1232724006622 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1232724006623 potential catalytic triad [active] 1232724006624 conserved cys residue [active] 1232724006625 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724006626 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724006627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006628 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232724006629 active site 1232724006630 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1232724006631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724006632 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1232724006633 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1232724006634 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1232724006635 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724006636 hydrophobic ligand binding site; other site 1232724006637 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724006638 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724006639 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1232724006640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006641 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232724006642 Cutinase; Region: Cutinase; pfam01083 1232724006643 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1232724006644 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1232724006645 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1232724006646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724006647 active site 1232724006648 phosphorylation site [posttranslational modification] 1232724006649 intermolecular recognition site; other site 1232724006650 dimerization interface [polypeptide binding]; other site 1232724006651 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1232724006652 Cutinase; Region: Cutinase; pfam01083 1232724006653 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724006654 PPE family; Region: PPE; pfam00823 1232724006655 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1232724006656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1232724006657 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1232724006658 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1232724006659 Walker A/P-loop; other site 1232724006660 ATP binding site [chemical binding]; other site 1232724006661 Q-loop/lid; other site 1232724006662 ABC transporter signature motif; other site 1232724006663 Walker B; other site 1232724006664 D-loop; other site 1232724006665 H-loop/switch region; other site 1232724006666 NMT1-like family; Region: NMT1_2; pfam13379 1232724006667 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1232724006668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232724006669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724006670 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1232724006671 putative dimerization interface [polypeptide binding]; other site 1232724006672 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724006673 PPE family; Region: PPE; pfam00823 1232724006674 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724006675 PPE family; Region: PPE; pfam00823 1232724006676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1232724006677 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1232724006678 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1232724006679 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724006680 SnoaL-like domain; Region: SnoaL_3; pfam13474 1232724006681 short chain dehydrogenase; Provisional; Region: PRK06500 1232724006682 classical (c) SDRs; Region: SDR_c; cd05233 1232724006683 NAD(P) binding site [chemical binding]; other site 1232724006684 active site 1232724006685 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1232724006686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724006687 S-adenosylmethionine binding site [chemical binding]; other site 1232724006688 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1232724006689 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1232724006690 putative oligomer interface [polypeptide binding]; other site 1232724006691 putative active site [active] 1232724006692 metal binding site [ion binding]; metal-binding site 1232724006693 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1232724006694 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724006695 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724006696 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1232724006697 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1232724006698 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1232724006699 hypothetical protein; Provisional; Region: PRK06834 1232724006700 hypothetical protein; Provisional; Region: PRK07236 1232724006701 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724006702 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1232724006703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724006704 ATP binding site [chemical binding]; other site 1232724006705 putative Mg++ binding site [ion binding]; other site 1232724006706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724006707 nucleotide binding region [chemical binding]; other site 1232724006708 ATP-binding site [chemical binding]; other site 1232724006709 Helicase associated domain (HA2); Region: HA2; pfam04408 1232724006710 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1232724006711 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1232724006712 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1232724006713 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1232724006714 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724006715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724006716 substrate binding site [chemical binding]; other site 1232724006717 oxyanion hole (OAH) forming residues; other site 1232724006718 trimer interface [polypeptide binding]; other site 1232724006719 Cutinase; Region: Cutinase; pfam01083 1232724006720 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1232724006721 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724006722 catalytic Zn binding site [ion binding]; other site 1232724006723 NAD(P) binding site [chemical binding]; other site 1232724006724 structural Zn binding site [ion binding]; other site 1232724006725 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724006726 hydrophobic ligand binding site; other site 1232724006727 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1232724006728 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724006729 NAD binding site [chemical binding]; other site 1232724006730 catalytic Zn binding site [ion binding]; other site 1232724006731 structural Zn binding site [ion binding]; other site 1232724006732 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1232724006733 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1232724006734 MOSC domain; Region: MOSC; pfam03473 1232724006735 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724006736 PPE family; Region: PPE; pfam00823 1232724006737 Short C-terminal domain; Region: SHOCT; pfam09851 1232724006738 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1232724006739 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1232724006740 active site 1232724006741 TDP-binding site; other site 1232724006742 acceptor substrate-binding pocket; other site 1232724006743 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232724006744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724006745 S-adenosylmethionine binding site [chemical binding]; other site 1232724006746 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1232724006747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724006748 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1232724006749 iron-sulfur cluster [ion binding]; other site 1232724006750 [2Fe-2S] cluster binding site [ion binding]; other site 1232724006751 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1232724006752 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1232724006753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232724006754 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232724006755 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1232724006756 metal binding site 2 [ion binding]; metal-binding site 1232724006757 putative DNA binding helix; other site 1232724006758 metal binding site 1 [ion binding]; metal-binding site 1232724006759 dimer interface [polypeptide binding]; other site 1232724006760 structural Zn2+ binding site [ion binding]; other site 1232724006761 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1232724006762 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1232724006763 dimer interface [polypeptide binding]; other site 1232724006764 active site 1232724006765 heme binding site [chemical binding]; other site 1232724006766 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1232724006767 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1232724006768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724006769 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724006770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724006771 S-adenosylmethionine binding site [chemical binding]; other site 1232724006772 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1232724006773 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1232724006774 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1232724006775 Cutinase; Region: Cutinase; pfam01083 1232724006776 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1232724006777 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1232724006778 Flavoprotein; Region: Flavoprotein; pfam02441 1232724006779 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724006780 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724006781 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1232724006782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724006783 substrate binding site [chemical binding]; other site 1232724006784 oxyanion hole (OAH) forming residues; other site 1232724006785 trimer interface [polypeptide binding]; other site 1232724006786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1232724006787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724006788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006789 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1232724006790 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724006791 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724006792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724006793 DNA-binding site [nucleotide binding]; DNA binding site 1232724006794 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1232724006795 FCD domain; Region: FCD; pfam07729 1232724006796 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1232724006797 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724006798 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724006799 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232724006800 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1232724006801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006802 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1232724006803 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006804 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724006805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006806 active site 1232724006807 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006808 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006809 active site 1232724006810 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1232724006811 active site 1232724006812 catalytic residues [active] 1232724006813 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724006814 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1232724006815 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724006816 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232724006817 NAD(P) binding site [chemical binding]; other site 1232724006818 catalytic residues [active] 1232724006819 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1232724006820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724006821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724006822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232724006823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724006824 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724006825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1232724006826 putative acyl-acceptor binding pocket; other site 1232724006827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724006828 S-adenosylmethionine binding site [chemical binding]; other site 1232724006829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006830 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724006831 extended (e) SDRs; Region: SDR_e; cd08946 1232724006832 NAD(P) binding site [chemical binding]; other site 1232724006833 active site 1232724006834 substrate binding site [chemical binding]; other site 1232724006835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006837 active site 1232724006838 YacP-like NYN domain; Region: NYN_YacP; cl01491 1232724006839 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1232724006840 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724006841 FMN binding site [chemical binding]; other site 1232724006842 substrate binding site [chemical binding]; other site 1232724006843 putative catalytic residue [active] 1232724006844 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1232724006845 dimer interface [polypeptide binding]; other site 1232724006846 catalytic triad [active] 1232724006847 peroxidatic and resolving cysteines [active] 1232724006848 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1232724006849 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1232724006850 conserved cys residue [active] 1232724006851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724006852 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1232724006853 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1232724006854 conserved cys residue [active] 1232724006855 Predicted transcriptional regulators [Transcription]; Region: COG1733 1232724006856 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1232724006857 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1232724006858 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724006859 short chain dehydrogenase; Provisional; Region: PRK05867 1232724006860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006861 NAD(P) binding site [chemical binding]; other site 1232724006862 active site 1232724006863 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724006864 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724006865 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1232724006866 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1232724006867 acyl-activating enzyme (AAE) consensus motif; other site 1232724006868 active site 1232724006869 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1232724006870 putative hydrophobic ligand binding site [chemical binding]; other site 1232724006871 protein interface [polypeptide binding]; other site 1232724006872 gate; other site 1232724006873 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232724006874 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724006875 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232724006876 tetramer interface [polypeptide binding]; other site 1232724006877 active site 1232724006878 Mg2+/Mn2+ binding site [ion binding]; other site 1232724006879 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1232724006880 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1232724006881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724006882 dimerization interface [polypeptide binding]; other site 1232724006883 putative DNA binding site [nucleotide binding]; other site 1232724006884 putative Zn2+ binding site [ion binding]; other site 1232724006885 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1232724006886 putative hydrophobic ligand binding site [chemical binding]; other site 1232724006887 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1232724006888 putative hydrophobic ligand binding site [chemical binding]; other site 1232724006889 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1232724006890 substrate binding site [chemical binding]; other site 1232724006891 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724006892 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724006893 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724006894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006895 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1232724006896 Nitronate monooxygenase; Region: NMO; pfam03060 1232724006897 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724006898 FMN binding site [chemical binding]; other site 1232724006899 substrate binding site [chemical binding]; other site 1232724006900 putative catalytic residue [active] 1232724006901 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1232724006902 FMN binding site [chemical binding]; other site 1232724006903 dimer interface [polypeptide binding]; other site 1232724006904 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724006905 hydrophobic ligand binding site; other site 1232724006906 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1232724006907 Predicted membrane protein [Function unknown]; Region: COG1950 1232724006908 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724006909 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1232724006910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1232724006911 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1232724006912 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724006913 active site 1232724006914 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1232724006915 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232724006916 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724006917 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1232724006918 short chain dehydrogenase; Provisional; Region: PRK08303 1232724006919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006920 NAD(P) binding site [chemical binding]; other site 1232724006921 active site 1232724006922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724006923 classical (c) SDRs; Region: SDR_c; cd05233 1232724006924 NAD(P) binding site [chemical binding]; other site 1232724006925 active site 1232724006926 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724006927 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724006928 hypothetical protein; Provisional; Region: PRK06194 1232724006929 classical (c) SDRs; Region: SDR_c; cd05233 1232724006930 NAD(P) binding site [chemical binding]; other site 1232724006931 active site 1232724006932 SnoaL-like domain; Region: SnoaL_4; cl17707 1232724006933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006934 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724006935 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006936 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006937 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006938 active site 1232724006939 acyl-CoA synthetase; Validated; Region: PRK08316 1232724006940 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724006941 acyl-activating enzyme (AAE) consensus motif; other site 1232724006942 putative AMP binding site [chemical binding]; other site 1232724006943 putative active site [active] 1232724006944 putative CoA binding site [chemical binding]; other site 1232724006945 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724006946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724006947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006948 NAD(P) binding site [chemical binding]; other site 1232724006949 active site 1232724006950 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1232724006951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724006952 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724006953 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232724006954 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1232724006955 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232724006956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724006957 short chain dehydrogenase; Provisional; Region: PRK06181 1232724006958 classical (c) SDRs; Region: SDR_c; cd05233 1232724006959 NAD(P) binding site [chemical binding]; other site 1232724006960 active site 1232724006961 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724006962 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724006963 NAD(P) binding site [chemical binding]; other site 1232724006964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724006965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724006967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724006968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724006969 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1232724006970 DinB superfamily; Region: DinB_2; pfam12867 1232724006971 hypothetical protein; Validated; Region: PRK07121 1232724006972 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232724006973 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1232724006974 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1232724006975 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1232724006976 active site 1232724006977 Fe binding site [ion binding]; other site 1232724006978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724006979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724006980 active site 1232724006981 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1232724006982 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724006983 catalytic loop [active] 1232724006984 iron binding site [ion binding]; other site 1232724006985 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724006986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724006987 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724006988 classical (c) SDRs; Region: SDR_c; cd05233 1232724006989 NAD(P) binding site [chemical binding]; other site 1232724006990 active site 1232724006991 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724006992 classical (c) SDRs; Region: SDR_c; cd05233 1232724006993 NAD(P) binding site [chemical binding]; other site 1232724006994 active site 1232724006995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724006996 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1232724006997 NAD(P) binding site [chemical binding]; other site 1232724006998 active site 1232724006999 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724007000 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724007001 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1232724007002 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724007003 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724007004 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724007005 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724007006 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1232724007007 molybdopterin cofactor binding site; other site 1232724007008 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1232724007009 putative molybdopterin cofactor binding site; other site 1232724007010 short chain dehydrogenase; Provisional; Region: PRK06057 1232724007011 classical (c) SDRs; Region: SDR_c; cd05233 1232724007012 NAD(P) binding site [chemical binding]; other site 1232724007013 active site 1232724007014 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724007015 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724007016 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724007017 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724007018 phosphopeptide binding site; other site 1232724007019 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724007020 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724007021 phosphopeptide binding site; other site 1232724007022 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1232724007023 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232724007024 Walker A/P-loop; other site 1232724007025 ATP binding site [chemical binding]; other site 1232724007026 Q-loop/lid; other site 1232724007027 ABC transporter signature motif; other site 1232724007028 Walker B; other site 1232724007029 D-loop; other site 1232724007030 H-loop/switch region; other site 1232724007031 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232724007032 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1232724007033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724007034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724007035 active site 1232724007036 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724007037 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724007038 active site 1232724007039 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232724007040 active site 1232724007041 catalytic site [active] 1232724007042 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1232724007043 putative active site [active] 1232724007044 putative catalytic site [active] 1232724007045 thiolase; Provisional; Region: PRK06158 1232724007046 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724007047 active site 1232724007048 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724007049 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724007050 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724007051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724007052 acyl-CoA synthetase; Provisional; Region: PRK13388 1232724007053 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724007054 acyl-activating enzyme (AAE) consensus motif; other site 1232724007055 AMP binding site [chemical binding]; other site 1232724007056 active site 1232724007057 CoA binding site [chemical binding]; other site 1232724007058 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1232724007059 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232724007060 FAD binding pocket [chemical binding]; other site 1232724007061 FAD binding motif [chemical binding]; other site 1232724007062 phosphate binding motif [ion binding]; other site 1232724007063 beta-alpha-beta structure motif; other site 1232724007064 NAD binding pocket [chemical binding]; other site 1232724007065 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724007066 catalytic loop [active] 1232724007067 iron binding site [ion binding]; other site 1232724007068 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1232724007069 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1232724007070 putative di-iron ligands [ion binding]; other site 1232724007071 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1232724007072 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1232724007073 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1232724007074 Moco binding site; other site 1232724007075 metal coordination site [ion binding]; other site 1232724007076 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724007077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724007078 acyl-activating enzyme (AAE) consensus motif; other site 1232724007079 AMP binding site [chemical binding]; other site 1232724007080 active site 1232724007081 CoA binding site [chemical binding]; other site 1232724007082 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1232724007083 intersubunit interface [polypeptide binding]; other site 1232724007084 active site 1232724007085 Zn2+ binding site [ion binding]; other site 1232724007086 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724007087 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724007088 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1232724007089 Nitronate monooxygenase; Region: NMO; pfam03060 1232724007090 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724007091 FMN binding site [chemical binding]; other site 1232724007092 substrate binding site [chemical binding]; other site 1232724007093 putative catalytic residue [active] 1232724007094 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1232724007095 Sulfatase; Region: Sulfatase; pfam00884 1232724007096 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724007097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724007098 S-adenosylmethionine binding site [chemical binding]; other site 1232724007099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724007100 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724007101 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1232724007102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724007103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724007104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724007105 Cytochrome P450; Region: p450; cl12078 1232724007106 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724007107 classical (c) SDRs; Region: SDR_c; cd05233 1232724007108 NAD(P) binding site [chemical binding]; other site 1232724007109 active site 1232724007110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724007111 enoyl-CoA hydratase; Provisional; Region: PRK12478 1232724007112 substrate binding site [chemical binding]; other site 1232724007113 oxyanion hole (OAH) forming residues; other site 1232724007114 trimer interface [polypeptide binding]; other site 1232724007115 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724007116 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724007117 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724007118 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724007119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724007120 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1232724007121 NAD(P) binding site [chemical binding]; other site 1232724007122 active site 1232724007123 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724007124 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232724007125 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232724007126 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1232724007127 active site 1232724007128 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232724007129 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232724007130 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1232724007131 active site 1232724007132 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724007133 short chain dehydrogenase; Provisional; Region: PRK05854 1232724007134 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1232724007135 putative NAD(P) binding site [chemical binding]; other site 1232724007136 active site 1232724007137 Cytochrome P450; Region: p450; cl12078 1232724007138 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724007139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724007140 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1232724007141 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1232724007142 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1232724007143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724007144 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1232724007145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724007146 DNA binding residues [nucleotide binding] 1232724007147 classical (c) SDRs; Region: SDR_c; cd05233 1232724007148 NAD(P) binding site [chemical binding]; other site 1232724007149 active site 1232724007150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724007151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724007152 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1232724007153 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724007154 active site 1232724007155 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724007156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724007157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724007158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724007159 S-adenosylmethionine binding site [chemical binding]; other site 1232724007160 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1232724007161 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1232724007162 ATP binding site [chemical binding]; other site 1232724007163 Mg++ binding site [ion binding]; other site 1232724007164 motif III; other site 1232724007165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724007166 nucleotide binding region [chemical binding]; other site 1232724007167 ATP-binding site [chemical binding]; other site 1232724007168 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 1232724007169 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1232724007170 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1232724007171 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1232724007172 enoyl-CoA hydratase; Provisional; Region: PRK12478 1232724007173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724007174 substrate binding site [chemical binding]; other site 1232724007175 oxyanion hole (OAH) forming residues; other site 1232724007176 trimer interface [polypeptide binding]; other site 1232724007177 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1232724007178 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724007179 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724007180 [2Fe-2S] cluster binding site [ion binding]; other site 1232724007181 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724007182 hydrophobic ligand binding site; other site 1232724007183 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1232724007184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724007185 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724007186 acyl-activating enzyme (AAE) consensus motif; other site 1232724007187 putative AMP binding site [chemical binding]; other site 1232724007188 putative active site [active] 1232724007189 acyl-activating enzyme (AAE) consensus motif; other site 1232724007190 putative CoA binding site [chemical binding]; other site 1232724007191 enoyl-CoA hydratase; Provisional; Region: PRK06144 1232724007192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724007193 substrate binding site [chemical binding]; other site 1232724007194 oxyanion hole (OAH) forming residues; other site 1232724007195 trimer interface [polypeptide binding]; other site 1232724007196 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232724007197 E3 interaction surface; other site 1232724007198 lipoyl attachment site [posttranslational modification]; other site 1232724007199 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1232724007200 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1232724007201 alpha subunit interface [polypeptide binding]; other site 1232724007202 TPP binding site [chemical binding]; other site 1232724007203 heterodimer interface [polypeptide binding]; other site 1232724007204 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1232724007205 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1232724007206 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1232724007207 tetramer interface [polypeptide binding]; other site 1232724007208 TPP-binding site [chemical binding]; other site 1232724007209 heterodimer interface [polypeptide binding]; other site 1232724007210 phosphorylation loop region [posttranslational modification] 1232724007211 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724007212 classical (c) SDRs; Region: SDR_c; cd05233 1232724007213 NAD(P) binding site [chemical binding]; other site 1232724007214 active site 1232724007215 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724007216 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724007217 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1232724007218 Helix-turn-helix domain; Region: HTH_18; pfam12833 1232724007219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724007220 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724007221 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724007222 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1232724007223 hydrophobic ligand binding site; other site 1232724007224 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1232724007225 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1232724007226 Moco binding site; other site 1232724007227 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1232724007228 metal coordination site [ion binding]; other site 1232724007229 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724007230 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724007231 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724007232 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1232724007233 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1232724007234 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1232724007235 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1232724007236 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724007237 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1232724007238 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724007239 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724007240 Cytochrome P450; Region: p450; cl12078 1232724007241 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1232724007242 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007243 PPE family; Region: PPE; pfam00823 1232724007244 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724007245 PE family; Region: PE; pfam00934 1232724007246 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007247 PPE family; Region: PPE; pfam00823 1232724007248 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007249 PPE family; Region: PPE; pfam00823 1232724007250 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724007251 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007252 PPE family; Region: PPE; pfam00823 1232724007253 PE family; Region: PE; pfam00934 1232724007254 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1232724007255 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1232724007256 EspG family; Region: ESX-1_EspG; pfam14011 1232724007257 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1232724007258 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1232724007259 catalytic residues [active] 1232724007260 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1232724007261 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1232724007262 active site 1232724007263 catalytic residues [active] 1232724007264 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1232724007265 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1232724007266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724007267 Walker A motif; other site 1232724007268 ATP binding site [chemical binding]; other site 1232724007269 Walker B motif; other site 1232724007270 arginine finger; other site 1232724007271 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007272 PPE family; Region: PPE; pfam00823 1232724007273 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007274 PPE family; Region: PPE; pfam00823 1232724007275 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724007276 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007277 PPE family; Region: PPE; pfam00823 1232724007278 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724007279 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724007280 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724007281 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007282 PPE family; Region: PPE; pfam00823 1232724007283 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724007284 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007285 PPE family; Region: PPE; pfam00823 1232724007286 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724007287 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724007288 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1232724007289 MgtC family; Region: MgtC; pfam02308 1232724007290 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1232724007291 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1232724007292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724007293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724007294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232724007295 hypothetical protein; Validated; Region: PRK07121 1232724007296 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232724007297 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1232724007298 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1232724007299 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1232724007300 hypothetical protein; Provisional; Region: PRK05858 1232724007301 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232724007302 PYR/PP interface [polypeptide binding]; other site 1232724007303 dimer interface [polypeptide binding]; other site 1232724007304 TPP binding site [chemical binding]; other site 1232724007305 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724007306 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1232724007307 TPP-binding site; other site 1232724007308 dimer interface [polypeptide binding]; other site 1232724007309 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1232724007310 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1232724007311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1232724007312 nucleotide binding region [chemical binding]; other site 1232724007313 ATP-binding site [chemical binding]; other site 1232724007314 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1232724007315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1232724007316 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1232724007317 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1232724007318 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1232724007319 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1232724007320 lipoyl attachment site [posttranslational modification]; other site 1232724007321 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724007322 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724007323 phosphopeptide binding site; other site 1232724007324 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1232724007325 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232724007326 DNA binding residues [nucleotide binding] 1232724007327 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1232724007328 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1232724007329 DNA binding residues [nucleotide binding] 1232724007330 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232724007331 putative dimer interface [polypeptide binding]; other site 1232724007332 glycine dehydrogenase; Provisional; Region: PRK05367 1232724007333 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1232724007334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724007335 tetramer interface [polypeptide binding]; other site 1232724007336 catalytic residue [active] 1232724007337 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1232724007338 tetramer interface [polypeptide binding]; other site 1232724007339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724007340 catalytic residue [active] 1232724007341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724007342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724007343 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1232724007344 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1232724007345 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1232724007346 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1232724007347 metal ion-dependent adhesion site (MIDAS); other site 1232724007348 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1232724007349 active site 1232724007350 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232724007351 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232724007352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232724007353 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1232724007354 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232724007355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232724007356 Transporter associated domain; Region: CorC_HlyC; smart01091 1232724007357 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1232724007358 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1232724007359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724007360 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724007361 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724007362 active site 1232724007363 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1232724007364 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724007365 acyl-activating enzyme (AAE) consensus motif; other site 1232724007366 AMP binding site [chemical binding]; other site 1232724007367 active site 1232724007368 CoA binding site [chemical binding]; other site 1232724007369 acyl carrier protein; Validated; Region: PRK05883 1232724007370 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1232724007371 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232724007372 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1232724007373 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1232724007374 active site 1232724007375 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1232724007376 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1232724007377 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1232724007378 Predicted transcriptional regulator [Transcription]; Region: COG3682 1232724007379 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724007380 CoenzymeA binding site [chemical binding]; other site 1232724007381 subunit interaction site [polypeptide binding]; other site 1232724007382 PHB binding site; other site 1232724007383 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232724007384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724007385 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1232724007386 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1232724007387 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724007388 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724007389 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1232724007390 classical (c) SDRs; Region: SDR_c; cd05233 1232724007391 NAD(P) binding site [chemical binding]; other site 1232724007392 active site 1232724007393 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1232724007394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1232724007395 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1232724007396 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1232724007397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724007398 putative PBP binding loops; other site 1232724007399 ABC-ATPase subunit interface; other site 1232724007400 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1232724007401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724007402 Walker A/P-loop; other site 1232724007403 ATP binding site [chemical binding]; other site 1232724007404 Q-loop/lid; other site 1232724007405 ABC transporter signature motif; other site 1232724007406 Walker B; other site 1232724007407 D-loop; other site 1232724007408 H-loop/switch region; other site 1232724007409 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1232724007410 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724007411 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1232724007412 NAD(P) binding site [chemical binding]; other site 1232724007413 CAAX protease self-immunity; Region: Abi; pfam02517 1232724007414 putative phosphoketolase; Provisional; Region: PRK05261 1232724007415 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1232724007416 TPP-binding site; other site 1232724007417 XFP C-terminal domain; Region: XFP_C; pfam09363 1232724007418 short chain dehydrogenase; Provisional; Region: PRK07825 1232724007419 classical (c) SDRs; Region: SDR_c; cd05233 1232724007420 NAD(P) binding site [chemical binding]; other site 1232724007421 active site 1232724007422 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1232724007423 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724007424 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724007425 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724007426 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724007427 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1232724007428 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724007429 active site 1232724007430 hypothetical protein; Provisional; Region: PRK12320 1232724007431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724007432 NAD(P) binding site [chemical binding]; other site 1232724007433 active site 1232724007434 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1232724007435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724007436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724007437 Protein of unknown function DUF72; Region: DUF72; pfam01904 1232724007438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1232724007439 minor groove reading motif; other site 1232724007440 helix-hairpin-helix signature motif; other site 1232724007441 TfoX N-terminal domain; Region: TfoX_N; cl17592 1232724007442 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724007443 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1232724007444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724007445 Walker A motif; other site 1232724007446 ATP binding site [chemical binding]; other site 1232724007447 Walker B motif; other site 1232724007448 arginine finger; other site 1232724007449 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1232724007450 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1232724007451 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1232724007452 active site 1232724007453 substrate binding site [chemical binding]; other site 1232724007454 FMN binding site [chemical binding]; other site 1232724007455 putative catalytic residues [active] 1232724007456 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1232724007457 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1232724007458 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1232724007459 active site 1232724007460 catalytic site [active] 1232724007461 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1232724007462 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724007463 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1232724007464 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1232724007465 dimer interface [polypeptide binding]; other site 1232724007466 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1232724007467 catalytic triad [active] 1232724007468 peroxidatic and resolving cysteines [active] 1232724007469 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1232724007470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724007471 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1232724007472 dimerization interface [polypeptide binding]; other site 1232724007473 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1232724007474 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724007475 substrate binding site [chemical binding]; other site 1232724007476 oxyanion hole (OAH) forming residues; other site 1232724007477 trimer interface [polypeptide binding]; other site 1232724007478 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1232724007479 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1232724007480 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1232724007481 heme binding site [chemical binding]; other site 1232724007482 ferroxidase pore; other site 1232724007483 ferroxidase diiron center [ion binding]; other site 1232724007484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724007485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232724007486 putative substrate translocation pore; other site 1232724007487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724007488 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724007489 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724007490 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1232724007491 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724007492 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1232724007493 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1232724007494 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724007495 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724007496 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724007497 Cytochrome P450; Region: p450; cl12078 1232724007498 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1232724007499 short chain dehydrogenase; Provisional; Region: PRK08267 1232724007500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724007501 NAD(P) binding site [chemical binding]; other site 1232724007502 active site 1232724007503 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724007504 hydrophobic ligand binding site; other site 1232724007505 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1232724007506 chorismate mutase; Provisional; Region: PRK09269 1232724007507 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1232724007508 Putative esterase; Region: Esterase; pfam00756 1232724007509 YceI-like domain; Region: YceI; smart00867 1232724007510 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1232724007511 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1232724007512 putative NAD(P) binding site [chemical binding]; other site 1232724007513 putative substrate binding site [chemical binding]; other site 1232724007514 catalytic Zn binding site [ion binding]; other site 1232724007515 structural Zn binding site [ion binding]; other site 1232724007516 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724007517 Cytochrome P450; Region: p450; cl12078 1232724007518 Nitronate monooxygenase; Region: NMO; pfam03060 1232724007519 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724007520 FMN binding site [chemical binding]; other site 1232724007521 substrate binding site [chemical binding]; other site 1232724007522 putative catalytic residue [active] 1232724007523 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724007524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724007525 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724007526 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724007527 NAD(P) binding site [chemical binding]; other site 1232724007528 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724007529 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724007530 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1232724007531 putative active site [active] 1232724007532 dimerization interface [polypeptide binding]; other site 1232724007533 putative tRNAtyr binding site [nucleotide binding]; other site 1232724007534 Domain of unknown function DUF77; Region: DUF77; pfam01910 1232724007535 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1232724007536 putative ADP-ribose binding site [chemical binding]; other site 1232724007537 competence damage-inducible protein A; Provisional; Region: PRK00549 1232724007538 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1232724007539 putative MPT binding site; other site 1232724007540 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1232724007541 putative sialic acid transporter; Region: 2A0112; TIGR00891 1232724007542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724007543 putative substrate translocation pore; other site 1232724007544 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724007545 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1232724007546 active site 1232724007547 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1232724007548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1232724007549 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1232724007550 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724007551 Predicted transcriptional regulators [Transcription]; Region: COG1695 1232724007552 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1232724007553 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724007554 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724007555 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232724007556 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232724007557 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1232724007558 hypothetical protein; Provisional; Region: PRK14059 1232724007559 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1232724007560 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724007561 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724007562 active site 1232724007563 ATP binding site [chemical binding]; other site 1232724007564 substrate binding site [chemical binding]; other site 1232724007565 activation loop (A-loop); other site 1232724007566 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1232724007567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724007568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724007569 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1232724007570 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232724007571 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724007572 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724007573 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1232724007574 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1232724007575 dimer interface [polypeptide binding]; other site 1232724007576 active site 1232724007577 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1232724007578 Ligand Binding Site [chemical binding]; other site 1232724007579 Molecular Tunnel; other site 1232724007580 Condensation domain; Region: Condensation; pfam00668 1232724007581 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007582 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724007583 acyl-activating enzyme (AAE) consensus motif; other site 1232724007584 AMP binding site [chemical binding]; other site 1232724007585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007586 Condensation domain; Region: Condensation; pfam00668 1232724007587 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724007588 Condensation domain; Region: Condensation; pfam00668 1232724007589 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724007590 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007591 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007592 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724007593 acyl-activating enzyme (AAE) consensus motif; other site 1232724007594 AMP binding site [chemical binding]; other site 1232724007595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724007596 S-adenosylmethionine binding site [chemical binding]; other site 1232724007597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724007598 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007599 Condensation domain; Region: Condensation; pfam00668 1232724007600 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724007601 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007602 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007603 acyl-activating enzyme (AAE) consensus motif; other site 1232724007604 AMP binding site [chemical binding]; other site 1232724007605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007606 Condensation domain; Region: Condensation; pfam00668 1232724007607 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724007608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007609 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007610 acyl-activating enzyme (AAE) consensus motif; other site 1232724007611 AMP binding site [chemical binding]; other site 1232724007612 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007613 peptide synthase; Provisional; Region: PRK12316 1232724007614 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007615 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007616 acyl-activating enzyme (AAE) consensus motif; other site 1232724007617 AMP binding site [chemical binding]; other site 1232724007618 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007619 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724007620 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007621 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007622 acyl-activating enzyme (AAE) consensus motif; other site 1232724007623 AMP binding site [chemical binding]; other site 1232724007624 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007625 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007626 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007627 acyl-activating enzyme (AAE) consensus motif; other site 1232724007628 AMP binding site [chemical binding]; other site 1232724007629 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007630 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724007631 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007632 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007633 acyl-activating enzyme (AAE) consensus motif; other site 1232724007634 AMP binding site [chemical binding]; other site 1232724007635 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007636 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1232724007637 MbtH-like protein; Region: MbtH; pfam03621 1232724007638 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1232724007639 ANTAR domain; Region: ANTAR; pfam03861 1232724007640 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1232724007641 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1232724007642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232724007643 DNA-binding site [nucleotide binding]; DNA binding site 1232724007644 RNA-binding motif; other site 1232724007645 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1232724007646 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1232724007647 putative di-iron ligands [ion binding]; other site 1232724007648 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1232724007649 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1232724007650 NAD(P) binding site [chemical binding]; other site 1232724007651 catalytic residues [active] 1232724007652 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1232724007653 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1232724007654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1232724007655 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1232724007656 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724007657 Peptidase family M48; Region: Peptidase_M48; cl12018 1232724007658 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1232724007659 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724007660 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1232724007661 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1232724007662 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1232724007663 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1232724007664 DNA binding residues [nucleotide binding] 1232724007665 dimer interface [polypeptide binding]; other site 1232724007666 metal binding site [ion binding]; metal-binding site 1232724007667 frameshift; Hypothetical protein 1232724007668 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1232724007669 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1232724007670 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1232724007671 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1232724007672 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1232724007673 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232724007674 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724007675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724007676 active site 1232724007677 motif I; other site 1232724007678 motif II; other site 1232724007679 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1232724007680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724007681 dimerization interface [polypeptide binding]; other site 1232724007682 putative DNA binding site [nucleotide binding]; other site 1232724007683 putative Zn2+ binding site [ion binding]; other site 1232724007684 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1232724007685 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1232724007686 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724007687 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1232724007688 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1232724007689 MgtE intracellular N domain; Region: MgtE_N; smart00924 1232724007690 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1232724007691 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1232724007692 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1232724007693 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724007694 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1232724007695 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1232724007696 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1232724007697 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1232724007698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724007699 S-adenosylmethionine binding site [chemical binding]; other site 1232724007700 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232724007701 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232724007702 dimer interface [polypeptide binding]; other site 1232724007703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724007704 catalytic residue [active] 1232724007705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232724007706 PE family; Region: PE; pfam00934 1232724007707 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007708 PPE family; Region: PPE; pfam00823 1232724007709 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1232724007710 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1232724007711 AAA ATPase domain; Region: AAA_16; pfam13191 1232724007712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724007713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724007714 DNA binding residues [nucleotide binding] 1232724007715 dimerization interface [polypeptide binding]; other site 1232724007716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724007717 DNA binding residues [nucleotide binding] 1232724007718 dimerization interface [polypeptide binding]; other site 1232724007719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724007720 DNA binding residues [nucleotide binding] 1232724007721 dimerization interface [polypeptide binding]; other site 1232724007722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724007723 Cytochrome P450; Region: p450; cl12078 1232724007724 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724007725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724007726 NAD(P) binding site [chemical binding]; other site 1232724007727 active site 1232724007728 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724007729 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724007730 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 1232724007731 cyclase homology domain; Region: CHD; cd07302 1232724007732 nucleotidyl binding site; other site 1232724007733 metal binding site [ion binding]; metal-binding site 1232724007734 dimer interface [polypeptide binding]; other site 1232724007735 AAA ATPase domain; Region: AAA_16; pfam13191 1232724007736 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724007737 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1232724007738 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1232724007739 NADH dehydrogenase; Region: NADHdh; cl00469 1232724007740 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1232724007741 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232724007742 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00150 1232724007743 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232724007744 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1232724007745 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232724007746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724007747 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232724007748 Integrase core domain; Region: rve; pfam00665 1232724007749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1232724007750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724007751 Walker A motif; other site 1232724007752 ATP binding site [chemical binding]; other site 1232724007753 Walker B motif; other site 1232724007754 HAMP domain; Region: HAMP; pfam00672 1232724007755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724007756 dimer interface [polypeptide binding]; other site 1232724007757 phosphorylation site [posttranslational modification] 1232724007758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724007759 ATP binding site [chemical binding]; other site 1232724007760 Mg2+ binding site [ion binding]; other site 1232724007761 G-X-G motif; other site 1232724007762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724007763 Response regulator receiver domain; Region: Response_reg; pfam00072 1232724007764 active site 1232724007765 phosphorylation site [posttranslational modification] 1232724007766 intermolecular recognition site; other site 1232724007767 dimerization interface [polypeptide binding]; other site 1232724007768 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232724007769 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232724007770 dimer interface [polypeptide binding]; other site 1232724007771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724007772 catalytic residue [active] 1232724007773 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1232724007774 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1232724007775 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1232724007776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724007777 catalytic residue [active] 1232724007778 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724007779 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1232724007780 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724007781 catalytic residue [active] 1232724007782 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1232724007783 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1232724007784 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1232724007785 active site 1232724007786 catalytic triad [active] 1232724007787 dimer interface [polypeptide binding]; other site 1232724007788 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724007789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1232724007790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724007791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724007792 WHG domain; Region: WHG; pfam13305 1232724007793 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724007794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724007795 active site 1232724007796 phosphorylation site [posttranslational modification] 1232724007797 intermolecular recognition site; other site 1232724007798 dimerization interface [polypeptide binding]; other site 1232724007799 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724007800 DNA binding site [nucleotide binding] 1232724007801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232724007802 dimerization interface [polypeptide binding]; other site 1232724007803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724007804 dimer interface [polypeptide binding]; other site 1232724007805 phosphorylation site [posttranslational modification] 1232724007806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724007807 ATP binding site [chemical binding]; other site 1232724007808 Mg2+ binding site [ion binding]; other site 1232724007809 G-X-G motif; other site 1232724007810 putative efflux protein, MATE family; Region: matE; TIGR00797 1232724007811 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1232724007812 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1232724007813 putative FMN binding site [chemical binding]; other site 1232724007814 NADPH bind site [chemical binding]; other site 1232724007815 Condensation domain; Region: Condensation; pfam00668 1232724007816 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724007817 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007818 acyl-activating enzyme (AAE) consensus motif; other site 1232724007819 AMP binding site [chemical binding]; other site 1232724007820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007821 Condensation domain; Region: Condensation; pfam00668 1232724007822 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724007823 Condensation domain; Region: Condensation; pfam00668 1232724007824 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007825 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724007826 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724007827 acyl-activating enzyme (AAE) consensus motif; other site 1232724007828 AMP binding site [chemical binding]; other site 1232724007829 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007830 Condensation domain; Region: Condensation; pfam00668 1232724007831 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724007832 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724007833 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724007834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1232724007835 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1232724007836 Thioesterase domain; Region: Thioesterase; pfam00975 1232724007837 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724007838 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1232724007839 active site 1232724007840 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232724007841 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724007842 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1232724007843 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724007844 NADP binding site [chemical binding]; other site 1232724007845 active site 1232724007846 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724007847 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232724007848 metal-binding site [ion binding] 1232724007849 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232724007850 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232724007851 metal-binding site [ion binding] 1232724007852 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724007853 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1232724007854 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724007855 PPE family; Region: PPE; pfam00823 1232724007856 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1232724007857 putative homodimer interface [polypeptide binding]; other site 1232724007858 putative homotetramer interface [polypeptide binding]; other site 1232724007859 putative allosteric switch controlling residues; other site 1232724007860 putative metal binding site [ion binding]; other site 1232724007861 putative homodimer-homodimer interface [polypeptide binding]; other site 1232724007862 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232724007863 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232724007864 dimer interface [polypeptide binding]; other site 1232724007865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724007866 catalytic residue [active] 1232724007867 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1232724007868 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1232724007869 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1232724007870 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1232724007871 dimer interface [polypeptide binding]; other site 1232724007872 active site 1232724007873 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232724007874 catalytic residues [active] 1232724007875 substrate binding site [chemical binding]; other site 1232724007876 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1232724007877 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1232724007878 cation binding site [ion binding]; other site 1232724007879 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1232724007880 MFS/sugar transport protein; Region: MFS_2; pfam13347 1232724007881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1232724007882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724007883 Walker A motif; other site 1232724007884 ATP binding site [chemical binding]; other site 1232724007885 Walker B motif; other site 1232724007886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724007887 Helix-turn-helix domain; Region: HTH_38; pfam13936 1232724007888 Integrase core domain; Region: rve; pfam00665 1232724007889 Transposase; Region: HTH_Tnp_1; cl17663 1232724007890 putative transposase OrfB; Reviewed; Region: PHA02517 1232724007891 HTH-like domain; Region: HTH_21; pfam13276 1232724007892 Integrase core domain; Region: rve; pfam00665 1232724007893 Integrase core domain; Region: rve_3; cl15866 1232724007894 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1232724007895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724007896 Walker A motif; other site 1232724007897 ATP binding site [chemical binding]; other site 1232724007898 Walker B motif; other site 1232724007899 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1232724007900 active site 1232724007901 catalytic residues [active] 1232724007902 DNA binding site [nucleotide binding] 1232724007903 Int/Topo IB signature motif; other site 1232724007904 GTP-binding protein Der; Reviewed; Region: PRK03003 1232724007905 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1232724007906 GTP/Mg2+ binding site [chemical binding]; other site 1232724007907 Switch I region; other site 1232724007908 G2 box; other site 1232724007909 Switch II region; other site 1232724007910 G3 box; other site 1232724007911 G4 box; other site 1232724007912 G5 box; other site 1232724007913 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1232724007914 G1 box; other site 1232724007915 GTP/Mg2+ binding site [chemical binding]; other site 1232724007916 Switch I region; other site 1232724007917 G2 box; other site 1232724007918 G3 box; other site 1232724007919 Switch II region; other site 1232724007920 G4 box; other site 1232724007921 G5 box; other site 1232724007922 cytidylate kinase; Provisional; Region: cmk; PRK00023 1232724007923 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1232724007924 CMP-binding site; other site 1232724007925 The sites determining sugar specificity; other site 1232724007926 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1232724007927 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232724007928 RNA binding surface [nucleotide binding]; other site 1232724007929 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1232724007930 active site 1232724007931 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1232724007932 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1232724007933 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1232724007934 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1232724007935 P loop; other site 1232724007936 Nucleotide binding site [chemical binding]; other site 1232724007937 DTAP/Switch II; other site 1232724007938 Switch I; other site 1232724007939 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232724007940 Magnesium ion binding site [ion binding]; other site 1232724007941 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1232724007942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724007943 S-adenosylmethionine binding site [chemical binding]; other site 1232724007944 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1232724007945 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232724007946 active site 1232724007947 DNA binding site [nucleotide binding] 1232724007948 Int/Topo IB signature motif; other site 1232724007949 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1232724007950 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1232724007951 dimer interface [polypeptide binding]; other site 1232724007952 active site 1232724007953 ADP-ribose binding site [chemical binding]; other site 1232724007954 nudix motif; other site 1232724007955 metal binding site [ion binding]; metal-binding site 1232724007956 CTP synthetase; Validated; Region: pyrG; PRK05380 1232724007957 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1232724007958 Catalytic site [active] 1232724007959 active site 1232724007960 UTP binding site [chemical binding]; other site 1232724007961 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1232724007962 active site 1232724007963 putative oxyanion hole; other site 1232724007964 catalytic triad [active] 1232724007965 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1232724007966 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1232724007967 Thiamine pyrophosphokinase; Region: TPK; cl08415 1232724007968 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1232724007969 DNA repair protein RecN; Region: recN; TIGR00634 1232724007970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724007971 Walker A/P-loop; other site 1232724007972 ATP binding site [chemical binding]; other site 1232724007973 Q-loop/lid; other site 1232724007974 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1232724007975 ABC transporter signature motif; other site 1232724007976 Walker B; other site 1232724007977 D-loop; other site 1232724007978 H-loop/switch region; other site 1232724007979 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1232724007980 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1232724007981 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1232724007982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232724007983 RNA binding surface [nucleotide binding]; other site 1232724007984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724007985 S-adenosylmethionine binding site [chemical binding]; other site 1232724007986 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1232724007987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724007988 active site 1232724007989 motif I; other site 1232724007990 motif II; other site 1232724007991 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1232724007992 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1232724007993 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724007994 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1232724007995 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1232724007996 active site 1232724007997 HIGH motif; other site 1232724007998 dimer interface [polypeptide binding]; other site 1232724007999 KMSKS motif; other site 1232724008000 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232724008001 RNA binding surface [nucleotide binding]; other site 1232724008002 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1232724008003 active site 1232724008004 DNA binding site [nucleotide binding] 1232724008005 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1232724008006 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1232724008007 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232724008008 Walker A/P-loop; other site 1232724008009 ATP binding site [chemical binding]; other site 1232724008010 Q-loop/lid; other site 1232724008011 ABC transporter signature motif; other site 1232724008012 Walker B; other site 1232724008013 D-loop; other site 1232724008014 H-loop/switch region; other site 1232724008015 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232724008016 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232724008017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724008018 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1232724008019 acyl-CoA synthetase; Validated; Region: PRK07868 1232724008020 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1232724008021 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724008022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724008023 active site 1232724008024 CoA binding site [chemical binding]; other site 1232724008025 AMP binding site [chemical binding]; other site 1232724008026 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1232724008027 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1232724008028 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1232724008029 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1232724008030 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1232724008031 short chain dehydrogenase; Provisional; Region: PRK07109 1232724008032 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1232724008033 putative NAD(P) binding site [chemical binding]; other site 1232724008034 active site 1232724008035 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 1232724008036 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1232724008037 putative active site pocket [active] 1232724008038 putative metal binding site [ion binding]; other site 1232724008039 frameshift; putative transcription antitermination regulator, ANTAR domain-containing protein 1232724008040 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1232724008041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232724008042 ABC transporter; Region: ABC_tran_2; pfam12848 1232724008043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232724008044 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724008045 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724008046 active site 1232724008047 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1232724008048 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1232724008049 malonyl-CoA binding site [chemical binding]; other site 1232724008050 dimer interface [polypeptide binding]; other site 1232724008051 active site 1232724008052 product binding site; other site 1232724008053 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232724008054 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724008055 active site 1232724008056 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724008057 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724008058 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232724008059 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724008060 active site 1232724008061 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724008062 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1232724008063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724008064 Enoylreductase; Region: PKS_ER; smart00829 1232724008065 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1232724008066 NAD(P) binding site [chemical binding]; other site 1232724008067 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1232724008068 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724008069 putative NADP binding site [chemical binding]; other site 1232724008070 active site 1232724008071 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724008072 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1232724008073 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1232724008074 active site 1232724008075 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1232724008076 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1232724008077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724008078 Enoylreductase; Region: PKS_ER; smart00829 1232724008079 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1232724008080 NAD(P) binding site [chemical binding]; other site 1232724008081 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1232724008082 putative NADP binding site [chemical binding]; other site 1232724008083 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724008084 active site 1232724008085 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1232724008086 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1232724008087 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1232724008088 malonyl-CoA binding site [chemical binding]; other site 1232724008089 dimer interface [polypeptide binding]; other site 1232724008090 active site 1232724008091 product binding site; other site 1232724008092 argininosuccinate lyase; Provisional; Region: PRK00855 1232724008093 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1232724008094 active sites [active] 1232724008095 tetramer interface [polypeptide binding]; other site 1232724008096 argininosuccinate synthase; Provisional; Region: PRK13820 1232724008097 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1232724008098 ANP binding site [chemical binding]; other site 1232724008099 Substrate Binding Site II [chemical binding]; other site 1232724008100 Substrate Binding Site I [chemical binding]; other site 1232724008101 arginine repressor; Provisional; Region: PRK03341 1232724008102 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1232724008103 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1232724008104 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1232724008105 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1232724008106 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1232724008107 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1232724008108 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232724008109 inhibitor-cofactor binding pocket; inhibition site 1232724008110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724008111 catalytic residue [active] 1232724008112 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1232724008113 feedback inhibition sensing region; other site 1232724008114 homohexameric interface [polypeptide binding]; other site 1232724008115 nucleotide binding site [chemical binding]; other site 1232724008116 N-acetyl-L-glutamate binding site [chemical binding]; other site 1232724008117 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1232724008118 heterotetramer interface [polypeptide binding]; other site 1232724008119 active site pocket [active] 1232724008120 cleavage site 1232724008121 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1232724008122 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1232724008123 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1232724008124 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1232724008125 putative tRNA-binding site [nucleotide binding]; other site 1232724008126 B3/4 domain; Region: B3_4; pfam03483 1232724008127 tRNA synthetase B5 domain; Region: B5; smart00874 1232724008128 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1232724008129 dimer interface [polypeptide binding]; other site 1232724008130 motif 1; other site 1232724008131 motif 3; other site 1232724008132 motif 2; other site 1232724008133 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1232724008134 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1232724008135 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1232724008136 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1232724008137 dimer interface [polypeptide binding]; other site 1232724008138 motif 1; other site 1232724008139 active site 1232724008140 motif 2; other site 1232724008141 motif 3; other site 1232724008142 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724008143 cyclase homology domain; Region: CHD; cd07302 1232724008144 nucleotidyl binding site; other site 1232724008145 metal binding site [ion binding]; metal-binding site 1232724008146 dimer interface [polypeptide binding]; other site 1232724008147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1232724008148 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232724008149 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1232724008150 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232724008151 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1232724008152 23S rRNA binding site [nucleotide binding]; other site 1232724008153 L21 binding site [polypeptide binding]; other site 1232724008154 L13 binding site [polypeptide binding]; other site 1232724008155 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1232724008156 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1232724008157 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1232724008158 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1232724008159 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1232724008160 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1232724008161 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1232724008162 dimer interface [polypeptide binding]; other site 1232724008163 putative anticodon binding site; other site 1232724008164 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232724008165 motif 1; other site 1232724008166 dimer interface [polypeptide binding]; other site 1232724008167 active site 1232724008168 motif 2; other site 1232724008169 motif 3; other site 1232724008170 Predicted esterase [General function prediction only]; Region: COG0627 1232724008171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724008172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724008173 hypothetical protein; Provisional; Region: PRK07877 1232724008174 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1232724008175 ATP binding site [chemical binding]; other site 1232724008176 substrate interface [chemical binding]; other site 1232724008177 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1232724008178 dimer interface [polypeptide binding]; other site 1232724008179 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1232724008180 Cytochrome P450; Region: p450; cl12078 1232724008181 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724008182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1232724008183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232724008184 metal binding site [ion binding]; metal-binding site 1232724008185 active site 1232724008186 I-site; other site 1232724008187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1232724008188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724008189 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724008190 S-adenosylmethionine binding site [chemical binding]; other site 1232724008191 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1232724008192 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1232724008193 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1232724008194 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1232724008195 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1232724008196 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724008197 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232724008198 Ligand Binding Site [chemical binding]; other site 1232724008199 Predicted membrane protein [Function unknown]; Region: COG5305 1232724008200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724008201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232724008202 putative substrate translocation pore; other site 1232724008203 excinuclease ABC subunit B; Provisional; Region: PRK05298 1232724008204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724008205 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724008206 nucleotide binding region [chemical binding]; other site 1232724008207 ATP-binding site [chemical binding]; other site 1232724008208 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1232724008209 UvrB/uvrC motif; Region: UVR; pfam02151 1232724008210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724008211 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1232724008212 active site 1232724008213 ATP binding site [chemical binding]; other site 1232724008214 substrate binding site [chemical binding]; other site 1232724008215 activation loop (A-loop); other site 1232724008216 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724008217 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724008218 phosphopeptide binding site; other site 1232724008219 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724008220 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724008221 phosphopeptide binding site; other site 1232724008222 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232724008223 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1232724008224 Walker A/P-loop; other site 1232724008225 ATP binding site [chemical binding]; other site 1232724008226 Q-loop/lid; other site 1232724008227 ABC transporter signature motif; other site 1232724008228 Walker B; other site 1232724008229 D-loop; other site 1232724008230 H-loop/switch region; other site 1232724008231 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1232724008232 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1232724008233 Protein of unknown function (DUF402); Region: DUF402; cl00979 1232724008234 putative anti-sigmaE protein; Provisional; Region: PRK13920 1232724008235 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1232724008236 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1232724008237 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724008238 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724008239 DNA binding residues [nucleotide binding] 1232724008240 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1232724008241 Fasciclin domain; Region: Fasciclin; pfam02469 1232724008242 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1232724008243 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1232724008244 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1232724008245 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232724008246 catalytic residues [active] 1232724008247 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1232724008248 Fasciclin domain; Region: Fasciclin; pfam02469 1232724008249 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1232724008250 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1232724008251 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1232724008252 DNA binding site [nucleotide binding] 1232724008253 catalytic residue [active] 1232724008254 H2TH interface [polypeptide binding]; other site 1232724008255 putative catalytic residues [active] 1232724008256 turnover-facilitating residue; other site 1232724008257 intercalation triad [nucleotide binding]; other site 1232724008258 8OG recognition residue [nucleotide binding]; other site 1232724008259 putative reading head residues; other site 1232724008260 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232724008261 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232724008262 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1232724008263 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1232724008264 CoA-binding site [chemical binding]; other site 1232724008265 ATP-binding [chemical binding]; other site 1232724008266 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1232724008267 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1232724008268 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1232724008269 RNA binding site [nucleotide binding]; other site 1232724008270 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1232724008271 RNA binding site [nucleotide binding]; other site 1232724008272 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1232724008273 RNA binding site [nucleotide binding]; other site 1232724008274 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1232724008275 RNA binding site [nucleotide binding]; other site 1232724008276 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1232724008277 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1232724008278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724008279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724008280 5'-3' exonuclease; Region: 53EXOc; smart00475 1232724008281 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1232724008282 active site 1232724008283 metal binding site 1 [ion binding]; metal-binding site 1232724008284 putative 5' ssDNA interaction site; other site 1232724008285 metal binding site 3; metal-binding site 1232724008286 metal binding site 2 [ion binding]; metal-binding site 1232724008287 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1232724008288 putative DNA binding site [nucleotide binding]; other site 1232724008289 putative metal binding site [ion binding]; other site 1232724008290 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1232724008291 DNA polymerase I; Provisional; Region: PRK05755 1232724008292 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1232724008293 active site 1232724008294 DNA binding site [nucleotide binding] 1232724008295 catalytic site [active] 1232724008296 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1232724008297 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724008298 lipid-transfer protein; Provisional; Region: PRK06059 1232724008299 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724008300 active site 1232724008301 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1232724008302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724008303 active site 1232724008304 phosphorylation site [posttranslational modification] 1232724008305 intermolecular recognition site; other site 1232724008306 dimerization interface [polypeptide binding]; other site 1232724008307 ANTAR domain; Region: ANTAR; pfam03861 1232724008308 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1232724008309 cyclase homology domain; Region: CHD; cd07302 1232724008310 nucleotidyl binding site; other site 1232724008311 metal binding site [ion binding]; metal-binding site 1232724008312 dimer interface [polypeptide binding]; other site 1232724008313 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1232724008314 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1232724008315 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1232724008316 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1232724008317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724008318 Walker A/P-loop; other site 1232724008319 ATP binding site [chemical binding]; other site 1232724008320 ABC transporter; Region: ABC_tran; pfam00005 1232724008321 Q-loop/lid; other site 1232724008322 ABC transporter signature motif; other site 1232724008323 Walker B; other site 1232724008324 D-loop; other site 1232724008325 H-loop/switch region; other site 1232724008326 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1232724008327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724008328 Walker A/P-loop; other site 1232724008329 ATP binding site [chemical binding]; other site 1232724008330 Q-loop/lid; other site 1232724008331 ABC transporter signature motif; other site 1232724008332 Walker B; other site 1232724008333 D-loop; other site 1232724008334 H-loop/switch region; other site 1232724008335 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1232724008336 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1232724008337 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1232724008338 active site 1232724008339 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1232724008340 catalytic triad [active] 1232724008341 dimer interface [polypeptide binding]; other site 1232724008342 pyruvate kinase; Provisional; Region: PRK06247 1232724008343 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1232724008344 active site 1232724008345 domain interfaces; other site 1232724008346 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1232724008347 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1232724008348 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1232724008349 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1232724008350 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1232724008351 substrate binding site [chemical binding]; other site 1232724008352 active site 1232724008353 catalytic residues [active] 1232724008354 heterodimer interface [polypeptide binding]; other site 1232724008355 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1232724008356 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1232724008357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724008358 catalytic residue [active] 1232724008359 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1232724008360 active site 1232724008361 ribulose/triose binding site [chemical binding]; other site 1232724008362 phosphate binding site [ion binding]; other site 1232724008363 substrate (anthranilate) binding pocket [chemical binding]; other site 1232724008364 product (indole) binding pocket [chemical binding]; other site 1232724008365 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1232724008366 anthranilate synthase component I; Provisional; Region: PRK13571 1232724008367 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1232724008368 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1232724008369 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1232724008370 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1232724008371 catalytic triad [active] 1232724008372 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1232724008373 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1232724008374 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1232724008375 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1232724008376 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1232724008377 substrate binding site [chemical binding]; other site 1232724008378 glutamase interaction surface [polypeptide binding]; other site 1232724008379 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232724008380 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1232724008381 active site 1232724008382 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1232724008383 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1232724008384 catalytic residues [active] 1232724008385 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1232724008386 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1232724008387 putative active site [active] 1232724008388 oxyanion strand; other site 1232724008389 catalytic triad [active] 1232724008390 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1232724008391 putative active site pocket [active] 1232724008392 4-fold oligomerization interface [polypeptide binding]; other site 1232724008393 metal binding residues [ion binding]; metal-binding site 1232724008394 3-fold/trimer interface [polypeptide binding]; other site 1232724008395 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1232724008396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724008397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724008398 homodimer interface [polypeptide binding]; other site 1232724008399 catalytic residue [active] 1232724008400 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1232724008401 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1232724008402 NAD binding site [chemical binding]; other site 1232724008403 dimerization interface [polypeptide binding]; other site 1232724008404 product binding site; other site 1232724008405 substrate binding site [chemical binding]; other site 1232724008406 zinc binding site [ion binding]; other site 1232724008407 catalytic residues [active] 1232724008408 Domain of unknown function (DUF385); Region: DUF385; cl04387 1232724008409 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1232724008410 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1232724008411 dimerization interface [polypeptide binding]; other site 1232724008412 active site 1232724008413 L-aspartate oxidase; Provisional; Region: PRK07804 1232724008414 L-aspartate oxidase; Provisional; Region: PRK06175 1232724008415 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1232724008416 quinolinate synthetase; Provisional; Region: PRK09375 1232724008417 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1232724008418 nudix motif; other site 1232724008419 Secretory lipase; Region: LIP; pfam03583 1232724008420 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1232724008421 biotin synthase; Validated; Region: PRK06256 1232724008422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724008423 FeS/SAM binding site; other site 1232724008424 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1232724008425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232724008426 dimerization interface [polypeptide binding]; other site 1232724008427 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1232724008428 cyclase homology domain; Region: CHD; cd07302 1232724008429 nucleotidyl binding site; other site 1232724008430 metal binding site [ion binding]; metal-binding site 1232724008431 dimer interface [polypeptide binding]; other site 1232724008432 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1232724008433 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232724008434 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232724008435 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232724008436 ligand binding site [chemical binding]; other site 1232724008437 flexible hinge region; other site 1232724008438 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1232724008439 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1232724008440 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1232724008441 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1232724008442 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1232724008443 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724008444 catalytic residue [active] 1232724008445 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1232724008446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232724008447 inhibitor-cofactor binding pocket; inhibition site 1232724008448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724008449 catalytic residue [active] 1232724008450 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232724008451 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232724008452 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724008453 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1232724008454 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1232724008455 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1232724008456 active site 1232724008457 catalytic site [active] 1232724008458 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1232724008459 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1232724008460 active site 1232724008461 catalytic site [active] 1232724008462 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1232724008463 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1232724008464 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1232724008465 catalytic site [active] 1232724008466 active site 1232724008467 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1232724008468 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1232724008469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724008470 DNA-binding site [nucleotide binding]; DNA binding site 1232724008471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724008472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724008473 homodimer interface [polypeptide binding]; other site 1232724008474 catalytic residue [active] 1232724008475 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1232724008476 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1232724008477 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1232724008478 active site 1232724008479 threonine dehydratase; Validated; Region: PRK08639 1232724008480 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1232724008481 tetramer interface [polypeptide binding]; other site 1232724008482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724008483 catalytic residue [active] 1232724008484 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1232724008485 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724008486 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1232724008487 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1232724008488 putative acyl-acceptor binding pocket; other site 1232724008489 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1232724008490 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1232724008491 acyl-activating enzyme (AAE) consensus motif; other site 1232724008492 putative AMP binding site [chemical binding]; other site 1232724008493 putative active site [active] 1232724008494 putative CoA binding site [chemical binding]; other site 1232724008495 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724008496 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1232724008497 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1232724008498 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1232724008499 DNA binding residues [nucleotide binding] 1232724008500 putative dimer interface [polypeptide binding]; other site 1232724008501 putative metal binding residues [ion binding]; other site 1232724008502 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1232724008503 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1232724008504 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1232724008505 active site 1232724008506 PHP Thumb interface [polypeptide binding]; other site 1232724008507 metal binding site [ion binding]; metal-binding site 1232724008508 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1232724008509 generic binding surface II; other site 1232724008510 generic binding surface I; other site 1232724008511 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724008512 hydrophobic ligand binding site; other site 1232724008513 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232724008514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724008515 NAD(P) binding site [chemical binding]; other site 1232724008516 active site 1232724008517 classical (c) SDRs; Region: SDR_c; cd05233 1232724008518 NAD(P) binding site [chemical binding]; other site 1232724008519 active site 1232724008520 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1232724008521 apolar tunnel; other site 1232724008522 heme binding site [chemical binding]; other site 1232724008523 dimerization interface [polypeptide binding]; other site 1232724008524 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232724008525 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1232724008526 S-adenosylmethionine binding site [chemical binding]; other site 1232724008527 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1232724008528 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1232724008529 active site 1232724008530 lipoprotein signal peptidase; Provisional; Region: PRK14764 1232724008531 lipoprotein signal peptidase; Provisional; Region: PRK14787 1232724008532 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1232724008533 active site 1232724008534 homodimer interface [polypeptide binding]; other site 1232724008535 homotetramer interface [polypeptide binding]; other site 1232724008536 DNA polymerase IV; Provisional; Region: PRK03348 1232724008537 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1232724008538 active site 1232724008539 DNA binding site [nucleotide binding] 1232724008540 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1232724008541 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1232724008542 HIGH motif; other site 1232724008543 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1232724008544 active site 1232724008545 KMSKS motif; other site 1232724008546 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1232724008547 tRNA binding surface [nucleotide binding]; other site 1232724008548 anticodon binding site; other site 1232724008549 Nitronate monooxygenase; Region: NMO; pfam03060 1232724008550 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724008551 FMN binding site [chemical binding]; other site 1232724008552 substrate binding site [chemical binding]; other site 1232724008553 putative catalytic residue [active] 1232724008554 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724008555 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724008556 Condensation domain; Region: Condensation; pfam00668 1232724008557 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008558 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724008559 acyl-activating enzyme (AAE) consensus motif; other site 1232724008560 AMP binding site [chemical binding]; other site 1232724008561 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008562 Condensation domain; Region: Condensation; pfam00668 1232724008563 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008564 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008565 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008566 acyl-activating enzyme (AAE) consensus motif; other site 1232724008567 AMP binding site [chemical binding]; other site 1232724008568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008569 peptide synthase; Provisional; Region: PRK12467 1232724008570 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008571 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008572 acyl-activating enzyme (AAE) consensus motif; other site 1232724008573 AMP binding site [chemical binding]; other site 1232724008574 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008575 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008576 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008577 acyl-activating enzyme (AAE) consensus motif; other site 1232724008578 AMP binding site [chemical binding]; other site 1232724008579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008580 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724008581 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008582 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008583 acyl-activating enzyme (AAE) consensus motif; other site 1232724008584 AMP binding site [chemical binding]; other site 1232724008585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008586 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008587 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008588 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008589 acyl-activating enzyme (AAE) consensus motif; other site 1232724008590 AMP binding site [chemical binding]; other site 1232724008591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008592 Condensation domain; Region: Condensation; pfam00668 1232724008593 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008594 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008595 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008596 acyl-activating enzyme (AAE) consensus motif; other site 1232724008597 AMP binding site [chemical binding]; other site 1232724008598 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008599 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1232724008600 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1232724008601 putative NAD(P) binding site [chemical binding]; other site 1232724008602 active site 1232724008603 putative substrate binding site [chemical binding]; other site 1232724008604 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008605 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724008606 acyl-activating enzyme (AAE) consensus motif; other site 1232724008607 AMP binding site [chemical binding]; other site 1232724008608 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008609 Condensation domain; Region: Condensation; pfam00668 1232724008610 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724008611 Condensation domain; Region: Condensation; pfam00668 1232724008612 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008613 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008614 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008615 acyl-activating enzyme (AAE) consensus motif; other site 1232724008616 AMP binding site [chemical binding]; other site 1232724008617 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008618 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1232724008619 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1232724008620 putative NAD(P) binding site [chemical binding]; other site 1232724008621 active site 1232724008622 putative substrate binding site [chemical binding]; other site 1232724008623 Condensation domain; Region: Condensation; pfam00668 1232724008624 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008625 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724008626 acyl-activating enzyme (AAE) consensus motif; other site 1232724008627 AMP binding site [chemical binding]; other site 1232724008628 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008629 Condensation domain; Region: Condensation; pfam00668 1232724008630 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724008631 Condensation domain; Region: Condensation; pfam00668 1232724008632 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008633 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008634 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008635 acyl-activating enzyme (AAE) consensus motif; other site 1232724008636 AMP binding site [chemical binding]; other site 1232724008637 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008638 Condensation domain; Region: Condensation; pfam00668 1232724008639 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724008640 Condensation domain; Region: Condensation; pfam00668 1232724008641 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008642 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008643 MbtH-like protein; Region: MbtH; pfam03621 1232724008644 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724008645 Transport protein; Region: actII; TIGR00833 1232724008646 Transport protein; Region: actII; TIGR00833 1232724008647 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1232724008648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724008649 Walker A/P-loop; other site 1232724008650 ATP binding site [chemical binding]; other site 1232724008651 Q-loop/lid; other site 1232724008652 ABC transporter signature motif; other site 1232724008653 Walker B; other site 1232724008654 D-loop; other site 1232724008655 H-loop/switch region; other site 1232724008656 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232724008657 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232724008658 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1232724008659 daunorubicin resistance protein C; Region: drrC; TIGR01248 1232724008660 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232724008661 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1232724008662 active site 1232724008663 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724008664 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232724008665 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1232724008666 metal-binding site 1232724008667 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1232724008668 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1232724008669 NADP binding site [chemical binding]; other site 1232724008670 active site 1232724008671 putative substrate binding site [chemical binding]; other site 1232724008672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724008673 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1232724008674 frameshift; Transposase 1232724008675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724008676 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1232724008677 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1232724008678 NADP-binding site; other site 1232724008679 homotetramer interface [polypeptide binding]; other site 1232724008680 substrate binding site [chemical binding]; other site 1232724008681 homodimer interface [polypeptide binding]; other site 1232724008682 active site 1232724008683 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1232724008684 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1232724008685 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1232724008686 homodimer interface [polypeptide binding]; other site 1232724008687 active site 1232724008688 TDP-binding site; other site 1232724008689 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1232724008690 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1232724008691 homodimer interface [polypeptide binding]; other site 1232724008692 active site 1232724008693 TDP-binding site; other site 1232724008694 acceptor substrate-binding pocket; other site 1232724008695 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232724008696 classical (c) SDRs; Region: SDR_c; cd05233 1232724008697 NAD(P) binding site [chemical binding]; other site 1232724008698 active site 1232724008699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724008700 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 1232724008701 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1232724008702 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1232724008703 homodimer interface [polypeptide binding]; other site 1232724008704 active site 1232724008705 TDP-binding site; other site 1232724008706 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1232724008707 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1232724008708 homodimer interface [polypeptide binding]; other site 1232724008709 active site 1232724008710 TDP-binding site; other site 1232724008711 acceptor substrate-binding pocket; other site 1232724008712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724008713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724008714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724008715 NAD(P) binding site [chemical binding]; other site 1232724008716 active site 1232724008717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1232724008718 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724008719 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724008720 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724008721 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1232724008722 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1232724008723 Walker A; other site 1232724008724 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1232724008725 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1232724008726 active site 1232724008727 substrate binding site [chemical binding]; other site 1232724008728 coenzyme B12 binding site [chemical binding]; other site 1232724008729 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1232724008730 B12 binding site [chemical binding]; other site 1232724008731 cobalt ligand [ion binding]; other site 1232724008732 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1232724008733 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1232724008734 heterodimer interface [polypeptide binding]; other site 1232724008735 substrate interaction site [chemical binding]; other site 1232724008736 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1232724008737 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1232724008738 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232724008739 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1232724008740 active site 1232724008741 substrate binding sites [chemical binding]; other site 1232724008742 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1232724008743 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1232724008744 putative di-iron ligands [ion binding]; other site 1232724008745 Condensation domain; Region: Condensation; pfam00668 1232724008746 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008747 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1232724008748 acyl-activating enzyme (AAE) consensus motif; other site 1232724008749 AMP binding site [chemical binding]; other site 1232724008750 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008751 Condensation domain; Region: Condensation; pfam00668 1232724008752 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724008753 Condensation domain; Region: Condensation; pfam00668 1232724008754 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008755 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008756 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1232724008757 acyl-activating enzyme (AAE) consensus motif; other site 1232724008758 AMP binding site [chemical binding]; other site 1232724008759 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724008760 Condensation domain; Region: Condensation; pfam00668 1232724008761 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1232724008762 Condensation domain; Region: Condensation; pfam00668 1232724008763 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1232724008764 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1232724008765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724008766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1232724008767 dimerization interface [polypeptide binding]; other site 1232724008768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724008769 dimer interface [polypeptide binding]; other site 1232724008770 phosphorylation site [posttranslational modification] 1232724008771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724008772 Mg2+ binding site [ion binding]; other site 1232724008773 G-X-G motif; other site 1232724008774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724008775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724008776 active site 1232724008777 phosphorylation site [posttranslational modification] 1232724008778 intermolecular recognition site; other site 1232724008779 dimerization interface [polypeptide binding]; other site 1232724008780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724008781 DNA binding site [nucleotide binding] 1232724008782 Domain of unknown function (DUF385); Region: DUF385; cl04387 1232724008783 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1232724008784 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1232724008785 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1232724008786 ferrochelatase; Reviewed; Region: hemH; PRK00035 1232724008787 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1232724008788 C-terminal domain interface [polypeptide binding]; other site 1232724008789 active site 1232724008790 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1232724008791 active site 1232724008792 N-terminal domain interface [polypeptide binding]; other site 1232724008793 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1232724008794 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1232724008795 NAD binding site [chemical binding]; other site 1232724008796 homotetramer interface [polypeptide binding]; other site 1232724008797 homodimer interface [polypeptide binding]; other site 1232724008798 substrate binding site [chemical binding]; other site 1232724008799 active site 1232724008800 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1232724008801 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1232724008802 NAD(P) binding site [chemical binding]; other site 1232724008803 homotetramer interface [polypeptide binding]; other site 1232724008804 homodimer interface [polypeptide binding]; other site 1232724008805 active site 1232724008806 hypothetical protein; Provisional; Region: PRK13685 1232724008807 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1232724008808 metal ion-dependent adhesion site (MIDAS); other site 1232724008809 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1232724008810 Protein of unknown function DUF58; Region: DUF58; pfam01882 1232724008811 MoxR-like ATPases [General function prediction only]; Region: COG0714 1232724008812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724008813 Walker A motif; other site 1232724008814 ATP binding site [chemical binding]; other site 1232724008815 Walker B motif; other site 1232724008816 arginine finger; other site 1232724008817 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232724008818 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232724008819 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1232724008820 NlpC/P60 family; Region: NLPC_P60; pfam00877 1232724008821 aconitate hydratase; Validated; Region: PRK09277 1232724008822 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1232724008823 substrate binding site [chemical binding]; other site 1232724008824 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1232724008825 ligand binding site [chemical binding]; other site 1232724008826 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1232724008827 substrate binding site [chemical binding]; other site 1232724008828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724008829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724008830 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1232724008831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724008832 Walker A/P-loop; other site 1232724008833 ATP binding site [chemical binding]; other site 1232724008834 Q-loop/lid; other site 1232724008835 ABC transporter signature motif; other site 1232724008836 Walker B; other site 1232724008837 D-loop; other site 1232724008838 H-loop/switch region; other site 1232724008839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232724008840 enoyl-CoA hydratase; Provisional; Region: PRK05864 1232724008841 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724008842 substrate binding site [chemical binding]; other site 1232724008843 oxyanion hole (OAH) forming residues; other site 1232724008844 trimer interface [polypeptide binding]; other site 1232724008845 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1232724008846 catalytic residues [active] 1232724008847 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1232724008848 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1232724008849 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724008850 active site 1232724008851 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1232724008852 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1232724008853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724008854 NAD(P) binding site [chemical binding]; other site 1232724008855 active site 1232724008856 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1232724008857 homotrimer interaction site [polypeptide binding]; other site 1232724008858 putative active site [active] 1232724008859 Cupin domain; Region: Cupin_2; pfam07883 1232724008860 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1232724008861 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724008862 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1232724008863 dimer interface [polypeptide binding]; other site 1232724008864 active site 1232724008865 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1232724008866 classical (c) SDRs; Region: SDR_c; cd05233 1232724008867 NAD(P) binding site [chemical binding]; other site 1232724008868 active site 1232724008869 Transport protein; Region: actII; TIGR00833 1232724008870 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724008871 O-methyltransferase; Region: Methyltransf_2; pfam00891 1232724008872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724008873 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1232724008874 putative substrate translocation pore; other site 1232724008875 FMN binding site [chemical binding]; other site 1232724008876 Nitroreductase family; Region: Nitroreductase; pfam00881 1232724008877 dimer interface [polypeptide binding]; other site 1232724008878 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1232724008879 homotrimer interaction site [polypeptide binding]; other site 1232724008880 putative active site [active] 1232724008881 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1232724008882 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232724008883 putative NAD(P) binding site [chemical binding]; other site 1232724008884 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1232724008885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724008886 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724008887 Cupin domain; Region: Cupin_2; cl17218 1232724008888 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232724008889 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1232724008890 putative NAD(P) binding site [chemical binding]; other site 1232724008891 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724008892 PPE family; Region: PPE; pfam00823 1232724008893 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724008894 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1232724008895 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1232724008896 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1232724008897 GAF domain; Region: GAF; cl17456 1232724008898 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1232724008899 DNA-binding interface [nucleotide binding]; DNA binding site 1232724008900 AAA ATPase domain; Region: AAA_16; pfam13191 1232724008901 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724008902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724008903 DNA binding residues [nucleotide binding] 1232724008904 dimerization interface [polypeptide binding]; other site 1232724008905 AAA ATPase domain; Region: AAA_16; pfam13191 1232724008906 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724008907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724008908 DNA binding residues [nucleotide binding] 1232724008909 dimerization interface [polypeptide binding]; other site 1232724008910 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1232724008911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724008912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724008913 DNA binding residues [nucleotide binding] 1232724008914 dimerization interface [polypeptide binding]; other site 1232724008915 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1232724008916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724008917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724008918 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724008919 Electron transfer DM13; Region: DM13; cl02735 1232724008920 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1232724008921 putative active site [active] 1232724008922 transaldolase; Provisional; Region: PRK03903 1232724008923 catalytic residue [active] 1232724008924 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1232724008925 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1232724008926 Moco binding site; other site 1232724008927 metal coordination site [ion binding]; other site 1232724008928 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232724008929 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 1232724008930 FAD binding pocket [chemical binding]; other site 1232724008931 FAD binding motif [chemical binding]; other site 1232724008932 phosphate binding motif [ion binding]; other site 1232724008933 beta-alpha-beta structure motif; other site 1232724008934 NAD binding pocket [chemical binding]; other site 1232724008935 DNL zinc finger; Region: zf-DNL; pfam05180 1232724008936 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1232724008937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1232724008938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232724008939 Protein of unknown function, DUF417; Region: DUF417; cl01162 1232724008940 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1232724008941 classical (c) SDRs; Region: SDR_c; cd05233 1232724008942 NAD(P) binding site [chemical binding]; other site 1232724008943 active site 1232724008944 SelR domain; Region: SelR; pfam01641 1232724008945 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1232724008946 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1232724008947 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1232724008948 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1232724008949 D-pathway; other site 1232724008950 Putative ubiquinol binding site [chemical binding]; other site 1232724008951 Low-spin heme (heme b) binding site [chemical binding]; other site 1232724008952 Putative water exit pathway; other site 1232724008953 Binuclear center (heme o3/CuB) [ion binding]; other site 1232724008954 K-pathway; other site 1232724008955 Putative proton exit pathway; other site 1232724008956 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1232724008957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724008958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724008959 Predicted membrane protein [Function unknown]; Region: COG2323 1232724008960 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1232724008961 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1232724008962 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1232724008963 trimerization site [polypeptide binding]; other site 1232724008964 active site 1232724008965 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1232724008966 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1232724008967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724008968 catalytic residue [active] 1232724008969 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1232724008970 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1232724008971 Walker A/P-loop; other site 1232724008972 ATP binding site [chemical binding]; other site 1232724008973 Q-loop/lid; other site 1232724008974 ABC transporter signature motif; other site 1232724008975 Walker B; other site 1232724008976 D-loop; other site 1232724008977 H-loop/switch region; other site 1232724008978 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1232724008979 FeS assembly protein SufD; Region: sufD; TIGR01981 1232724008980 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1232724008981 FeS assembly protein SufB; Region: sufB; TIGR01980 1232724008982 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232724008983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724008984 putative DNA binding site [nucleotide binding]; other site 1232724008985 putative Zn2+ binding site [ion binding]; other site 1232724008986 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1232724008987 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232724008988 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232724008989 Walker A/P-loop; other site 1232724008990 ATP binding site [chemical binding]; other site 1232724008991 Q-loop/lid; other site 1232724008992 ABC transporter signature motif; other site 1232724008993 Walker B; other site 1232724008994 D-loop; other site 1232724008995 H-loop/switch region; other site 1232724008996 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232724008997 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1232724008998 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1232724008999 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1232724009000 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1232724009001 NADP binding site [chemical binding]; other site 1232724009002 dimer interface [polypeptide binding]; other site 1232724009003 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1232724009004 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232724009005 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1232724009006 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1232724009007 TPP-binding site [chemical binding]; other site 1232724009008 dimer interface [polypeptide binding]; other site 1232724009009 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1232724009010 PYR/PP interface [polypeptide binding]; other site 1232724009011 dimer interface [polypeptide binding]; other site 1232724009012 TPP binding site [chemical binding]; other site 1232724009013 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1232724009014 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1232724009015 putative active site [active] 1232724009016 transaldolase; Provisional; Region: PRK03903 1232724009017 catalytic residue [active] 1232724009018 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1232724009019 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1232724009020 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1232724009021 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1232724009022 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1232724009023 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1232724009024 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1232724009025 putative active site [active] 1232724009026 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1232724009027 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1232724009028 putative active site [active] 1232724009029 Zn binding site [ion binding]; other site 1232724009030 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724009031 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724009032 active site 1232724009033 catalytic tetrad [active] 1232724009034 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1232724009035 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1232724009036 Preprotein translocase SecG subunit; Region: SecG; cl09123 1232724009037 triosephosphate isomerase; Provisional; Region: PRK14567 1232724009038 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1232724009039 substrate binding site [chemical binding]; other site 1232724009040 dimer interface [polypeptide binding]; other site 1232724009041 catalytic triad [active] 1232724009042 Phosphoglycerate kinase; Region: PGK; pfam00162 1232724009043 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1232724009044 substrate binding site [chemical binding]; other site 1232724009045 hinge regions; other site 1232724009046 ADP binding site [chemical binding]; other site 1232724009047 catalytic site [active] 1232724009048 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1232724009049 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1232724009050 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1232724009051 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724009052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724009053 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1232724009054 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724009055 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1232724009056 putative acyl-acceptor binding pocket; other site 1232724009057 acyl-CoA synthetase; Provisional; Region: PRK13382 1232724009058 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724009059 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724009060 acyl-activating enzyme (AAE) consensus motif; other site 1232724009061 putative AMP binding site [chemical binding]; other site 1232724009062 putative active site [active] 1232724009063 putative CoA binding site [chemical binding]; other site 1232724009064 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1232724009065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724009066 substrate binding pocket [chemical binding]; other site 1232724009067 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724009068 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724009069 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724009070 active site 1232724009071 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724009072 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724009073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1232724009074 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1232724009075 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1232724009076 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1232724009077 phosphate binding site [ion binding]; other site 1232724009078 putative substrate binding pocket [chemical binding]; other site 1232724009079 dimer interface [polypeptide binding]; other site 1232724009080 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1232724009081 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1232724009082 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1232724009083 GIY-YIG motif/motif A; other site 1232724009084 active site 1232724009085 catalytic site [active] 1232724009086 putative DNA binding site [nucleotide binding]; other site 1232724009087 metal binding site [ion binding]; metal-binding site 1232724009088 UvrB/uvrC motif; Region: UVR; pfam02151 1232724009089 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1232724009090 Helix-hairpin-helix motif; Region: HHH; pfam00633 1232724009091 Cupin superfamily protein; Region: Cupin_4; pfam08007 1232724009092 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724009093 PPE family; Region: PPE; pfam00823 1232724009094 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1232724009095 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1232724009096 homopentamer interface [polypeptide binding]; other site 1232724009097 active site 1232724009098 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1232724009099 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1232724009100 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1232724009101 dimerization interface [polypeptide binding]; other site 1232724009102 active site 1232724009103 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1232724009104 Lumazine binding domain; Region: Lum_binding; pfam00677 1232724009105 Lumazine binding domain; Region: Lum_binding; pfam00677 1232724009106 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1232724009107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724009108 putative substrate translocation pore; other site 1232724009109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724009110 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1232724009111 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1232724009112 catalytic motif [active] 1232724009113 Zn binding site [ion binding]; other site 1232724009114 RibD C-terminal domain; Region: RibD_C; pfam01872 1232724009115 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1232724009116 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1232724009117 substrate binding site [chemical binding]; other site 1232724009118 hexamer interface [polypeptide binding]; other site 1232724009119 metal binding site [ion binding]; metal-binding site 1232724009120 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1232724009121 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1232724009122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724009123 S-adenosylmethionine binding site [chemical binding]; other site 1232724009124 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1232724009125 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1232724009126 putative active site [active] 1232724009127 substrate binding site [chemical binding]; other site 1232724009128 putative cosubstrate binding site; other site 1232724009129 catalytic site [active] 1232724009130 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1232724009131 substrate binding site [chemical binding]; other site 1232724009132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724009133 S-adenosylmethionine binding site [chemical binding]; other site 1232724009134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724009135 MarR family; Region: MarR; pfam01047 1232724009136 primosome assembly protein PriA; Provisional; Region: PRK14873 1232724009137 Predicted membrane protein [Function unknown]; Region: COG3714 1232724009138 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724009139 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724009140 substrate binding pocket [chemical binding]; other site 1232724009141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724009142 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724009143 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1232724009144 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1232724009145 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1232724009146 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1232724009147 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1232724009148 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1232724009149 Flavoprotein; Region: Flavoprotein; pfam02441 1232724009150 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1232724009151 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1232724009152 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1232724009153 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1232724009154 catalytic site [active] 1232724009155 G-X2-G-X-G-K; other site 1232724009156 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1232724009157 DNA binding residues [nucleotide binding] 1232724009158 TOBE domain; Region: TOBE; cl01440 1232724009159 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1232724009160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1232724009161 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1232724009162 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1232724009163 active site 1232724009164 dimer interface [polypeptide binding]; other site 1232724009165 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1232724009166 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232724009167 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724009168 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1232724009169 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232724009170 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724009171 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1232724009172 IMP binding site; other site 1232724009173 dimer interface [polypeptide binding]; other site 1232724009174 interdomain contacts; other site 1232724009175 partial ornithine binding site; other site 1232724009176 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1232724009177 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1232724009178 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1232724009179 catalytic site [active] 1232724009180 subunit interface [polypeptide binding]; other site 1232724009181 dihydroorotase; Validated; Region: pyrC; PRK09357 1232724009182 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724009183 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1232724009184 active site 1232724009185 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1232724009186 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1232724009187 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1232724009188 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1232724009189 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1232724009190 active site 1232724009191 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724009192 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724009193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1232724009194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232724009195 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1232724009196 L-aspartate oxidase; Provisional; Region: PRK06175 1232724009197 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1232724009198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1232724009199 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1232724009200 Walker A/P-loop; other site 1232724009201 ATP binding site [chemical binding]; other site 1232724009202 Q-loop/lid; other site 1232724009203 ABC transporter signature motif; other site 1232724009204 Walker B; other site 1232724009205 D-loop; other site 1232724009206 H-loop/switch region; other site 1232724009207 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1232724009208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724009209 dimer interface [polypeptide binding]; other site 1232724009210 conserved gate region; other site 1232724009211 putative PBP binding loops; other site 1232724009212 ABC-ATPase subunit interface; other site 1232724009213 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1232724009214 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1232724009215 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1232724009216 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1232724009217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724009218 DNA-binding site [nucleotide binding]; DNA binding site 1232724009219 UTRA domain; Region: UTRA; pfam07702 1232724009220 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1232724009221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724009222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724009223 catalytic residue [active] 1232724009224 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1232724009225 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1232724009226 elongation factor P; Validated; Region: PRK00529 1232724009227 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1232724009228 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1232724009229 RNA binding site [nucleotide binding]; other site 1232724009230 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1232724009231 RNA binding site [nucleotide binding]; other site 1232724009232 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232724009233 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232724009234 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1232724009235 active site 1232724009236 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1232724009237 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1232724009238 trimer interface [polypeptide binding]; other site 1232724009239 active site 1232724009240 dimer interface [polypeptide binding]; other site 1232724009241 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1232724009242 active site 1232724009243 dimer interface [polypeptide binding]; other site 1232724009244 metal binding site [ion binding]; metal-binding site 1232724009245 shikimate kinase; Reviewed; Region: aroK; PRK00131 1232724009246 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1232724009247 ADP binding site [chemical binding]; other site 1232724009248 magnesium binding site [ion binding]; other site 1232724009249 putative shikimate binding site; other site 1232724009250 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1232724009251 chorismate synthase; Validated; Region: PRK05382 1232724009252 Tetramer interface [polypeptide binding]; other site 1232724009253 active site 1232724009254 FMN-binding site [chemical binding]; other site 1232724009255 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1232724009256 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1232724009257 active site 1232724009258 dimer interface [polypeptide binding]; other site 1232724009259 non-prolyl cis peptide bond; other site 1232724009260 insertion regions; other site 1232724009261 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1232724009262 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1232724009263 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1232724009264 shikimate binding site; other site 1232724009265 NAD(P) binding site [chemical binding]; other site 1232724009266 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1232724009267 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1232724009268 dimerization interface [polypeptide binding]; other site 1232724009269 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1232724009270 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1232724009271 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1232724009272 motif 1; other site 1232724009273 active site 1232724009274 motif 2; other site 1232724009275 motif 3; other site 1232724009276 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1232724009277 DHHA1 domain; Region: DHHA1; pfam02272 1232724009278 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1232724009279 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1232724009280 recombination factor protein RarA; Reviewed; Region: PRK13342 1232724009281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724009282 Walker A motif; other site 1232724009283 ATP binding site [chemical binding]; other site 1232724009284 Walker B motif; other site 1232724009285 arginine finger; other site 1232724009286 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1232724009287 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1232724009288 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1232724009289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1232724009290 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1232724009291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1232724009292 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1232724009293 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1232724009294 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1232724009295 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1232724009296 Protein of unknown function (DUF419); Region: DUF419; cl15265 1232724009297 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1232724009298 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724009299 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1232724009300 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1232724009301 dimer interface [polypeptide binding]; other site 1232724009302 anticodon binding site; other site 1232724009303 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1232724009304 homodimer interface [polypeptide binding]; other site 1232724009305 motif 1; other site 1232724009306 active site 1232724009307 motif 2; other site 1232724009308 GAD domain; Region: GAD; pfam02938 1232724009309 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232724009310 active site 1232724009311 motif 3; other site 1232724009312 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1232724009313 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1232724009314 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1232724009315 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1232724009316 putative hydrophobic ligand binding site [chemical binding]; other site 1232724009317 protein interface [polypeptide binding]; other site 1232724009318 gate; other site 1232724009319 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1232724009320 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1232724009321 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1232724009322 inhibitor site; inhibition site 1232724009323 active site 1232724009324 dimer interface [polypeptide binding]; other site 1232724009325 catalytic residue [active] 1232724009326 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1232724009327 intersubunit interface [polypeptide binding]; other site 1232724009328 active site 1232724009329 Zn2+ binding site [ion binding]; other site 1232724009330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724009331 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724009332 non-specific DNA binding site [nucleotide binding]; other site 1232724009333 salt bridge; other site 1232724009334 sequence-specific DNA binding site [nucleotide binding]; other site 1232724009335 Cupin domain; Region: Cupin_2; pfam07883 1232724009336 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1232724009337 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232724009338 active site 1232724009339 metal binding site [ion binding]; metal-binding site 1232724009340 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1232724009341 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232724009342 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724009343 hydrophobic ligand binding site; other site 1232724009344 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724009345 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724009346 active site 1232724009347 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1232724009348 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1232724009349 dimer interface [polypeptide binding]; other site 1232724009350 motif 1; other site 1232724009351 active site 1232724009352 motif 2; other site 1232724009353 motif 3; other site 1232724009354 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1232724009355 anticodon binding site; other site 1232724009356 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1232724009357 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1232724009358 active site 1232724009359 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1232724009360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232724009361 Zn2+ binding site [ion binding]; other site 1232724009362 Mg2+ binding site [ion binding]; other site 1232724009363 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1232724009364 synthetase active site [active] 1232724009365 NTP binding site [chemical binding]; other site 1232724009366 metal binding site [ion binding]; metal-binding site 1232724009367 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1232724009368 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1232724009369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232724009370 active site 1232724009371 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1232724009372 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1232724009373 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1232724009374 Protein export membrane protein; Region: SecD_SecF; pfam02355 1232724009375 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1232724009376 Protein export membrane protein; Region: SecD_SecF; cl14618 1232724009377 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1232724009378 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1232724009379 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232724009380 inhibitor-cofactor binding pocket; inhibition site 1232724009381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724009382 catalytic residue [active] 1232724009383 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1232724009384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724009385 acyl-activating enzyme (AAE) consensus motif; other site 1232724009386 AMP binding site [chemical binding]; other site 1232724009387 active site 1232724009388 CoA binding site [chemical binding]; other site 1232724009389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724009390 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1232724009391 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1232724009392 putative NAD(P) binding site [chemical binding]; other site 1232724009393 active site 1232724009394 putative substrate binding site [chemical binding]; other site 1232724009395 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1232724009396 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1232724009397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724009398 Walker A motif; other site 1232724009399 ATP binding site [chemical binding]; other site 1232724009400 Walker B motif; other site 1232724009401 arginine finger; other site 1232724009402 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1232724009403 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1232724009404 RuvA N terminal domain; Region: RuvA_N; pfam01330 1232724009405 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1232724009406 active site 1232724009407 putative DNA-binding cleft [nucleotide binding]; other site 1232724009408 dimer interface [polypeptide binding]; other site 1232724009409 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1232724009410 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1232724009411 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1232724009412 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1232724009413 spermidine synthase; Provisional; Region: PRK03612 1232724009414 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1232724009415 hypothetical protein; Validated; Region: PRK00110 1232724009416 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1232724009417 predicted active site [active] 1232724009418 catalytic triad [active] 1232724009419 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1232724009420 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1232724009421 active site 1232724009422 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1232724009423 catalytic triad [active] 1232724009424 dimer interface [polypeptide binding]; other site 1232724009425 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1232724009426 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1232724009427 active site 1232724009428 multimer interface [polypeptide binding]; other site 1232724009429 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1232724009430 nudix motif; other site 1232724009431 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724009432 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1232724009433 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1232724009434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1232724009435 putative acyl-acceptor binding pocket; other site 1232724009436 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1232724009437 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1232724009438 nucleotide binding site/active site [active] 1232724009439 HIT family signature motif; other site 1232724009440 catalytic residue [active] 1232724009441 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1232724009442 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1232724009443 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1232724009444 active site 1232724009445 dimer interface [polypeptide binding]; other site 1232724009446 motif 1; other site 1232724009447 motif 2; other site 1232724009448 motif 3; other site 1232724009449 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1232724009450 anticodon binding site; other site 1232724009451 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1232724009452 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724009453 CoenzymeA binding site [chemical binding]; other site 1232724009454 subunit interaction site [polypeptide binding]; other site 1232724009455 PHB binding site; other site 1232724009456 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724009457 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724009458 active site 1232724009459 catalytic tetrad [active] 1232724009460 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1232724009461 Helix-turn-helix domain; Region: HTH_20; pfam12840 1232724009462 putative DNA binding site [nucleotide binding]; other site 1232724009463 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232724009464 putative Zn2+ binding site [ion binding]; other site 1232724009465 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724009466 FMN binding site [chemical binding]; other site 1232724009467 substrate binding site [chemical binding]; other site 1232724009468 putative catalytic residue [active] 1232724009469 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1232724009470 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232724009471 Helix-turn-helix domain; Region: HTH_20; pfam12840 1232724009472 putative DNA binding site [nucleotide binding]; other site 1232724009473 putative Zn2+ binding site [ion binding]; other site 1232724009474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724009475 S-adenosylmethionine binding site [chemical binding]; other site 1232724009476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724009477 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1232724009478 tetramer interface [polypeptide binding]; other site 1232724009479 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1232724009480 active site 1232724009481 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1232724009482 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1232724009483 active site 1232724009484 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724009485 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1232724009486 iron-sulfur cluster [ion binding]; other site 1232724009487 [2Fe-2S] cluster binding site [ion binding]; other site 1232724009488 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 1232724009489 alpha subunit interaction site [polypeptide binding]; other site 1232724009490 beta subunit interaction site [polypeptide binding]; other site 1232724009491 iron-sulfur cluster [ion binding]; other site 1232724009492 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1232724009493 beta subunit interface [polypeptide binding]; other site 1232724009494 alpha subunit interface [polypeptide binding]; other site 1232724009495 active site 1232724009496 substrate binding site [chemical binding]; other site 1232724009497 Fe binding site [ion binding]; other site 1232724009498 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1232724009499 inter-subunit interface; other site 1232724009500 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1232724009501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724009502 NAD(P) binding site [chemical binding]; other site 1232724009503 active site 1232724009504 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1232724009505 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1232724009506 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232724009507 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232724009508 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232724009509 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1232724009510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724009511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724009512 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724009513 anti sigma factor interaction site; other site 1232724009514 regulatory phosphorylation site [posttranslational modification]; other site 1232724009515 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1232724009516 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1232724009517 Predicted permeases [General function prediction only]; Region: COG0730 1232724009518 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1232724009519 putative heme binding pocket [chemical binding]; other site 1232724009520 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724009521 classical (c) SDRs; Region: SDR_c; cd05233 1232724009522 NAD(P) binding site [chemical binding]; other site 1232724009523 active site 1232724009524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724009525 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1232724009526 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724009527 acyl-activating enzyme (AAE) consensus motif; other site 1232724009528 putative AMP binding site [chemical binding]; other site 1232724009529 putative active site [active] 1232724009530 putative CoA binding site [chemical binding]; other site 1232724009531 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232724009532 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1232724009533 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724009534 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724009535 substrate binding site [chemical binding]; other site 1232724009536 oxyanion hole (OAH) forming residues; other site 1232724009537 trimer interface [polypeptide binding]; other site 1232724009538 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724009539 hydrophobic ligand binding site; other site 1232724009540 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1232724009541 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1232724009542 transposase/IS protein; Provisional; Region: PRK09183 1232724009543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724009544 Walker A motif; other site 1232724009545 ATP binding site [chemical binding]; other site 1232724009546 Walker B motif; other site 1232724009547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724009548 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232724009549 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1232724009550 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724009551 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724009552 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1232724009553 classical (c) SDRs; Region: SDR_c; cd05233 1232724009554 NAD(P) binding site [chemical binding]; other site 1232724009555 active site 1232724009556 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232724009557 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1232724009558 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724009559 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1232724009560 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724009561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724009562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724009563 short chain dehydrogenase; Provisional; Region: PRK12827 1232724009564 classical (c) SDRs; Region: SDR_c; cd05233 1232724009565 NAD(P) binding site [chemical binding]; other site 1232724009566 active site 1232724009567 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724009568 classical (c) SDRs; Region: SDR_c; cd05233 1232724009569 NAD(P) binding site [chemical binding]; other site 1232724009570 active site 1232724009571 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1232724009572 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1232724009573 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724009574 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232724009575 NAD(P) binding site [chemical binding]; other site 1232724009576 catalytic residues [active] 1232724009577 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1232724009578 Cation efflux family; Region: Cation_efflux; cl00316 1232724009579 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724009580 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724009581 Clp amino terminal domain; Region: Clp_N; pfam02861 1232724009582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724009583 Coenzyme A binding pocket [chemical binding]; other site 1232724009584 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1232724009585 hypothetical protein; Provisional; Region: PRK14059 1232724009586 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1232724009587 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724009588 TAP-like protein; Region: Abhydrolase_4; pfam08386 1232724009589 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1232724009590 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1232724009591 SelR domain; Region: SelR; pfam01641 1232724009592 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232724009593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724009594 S-adenosylmethionine binding site [chemical binding]; other site 1232724009595 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1232724009596 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1232724009597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724009598 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1232724009599 substrate binding site [chemical binding]; other site 1232724009600 active site 1232724009601 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724009602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724009603 substrate binding site [chemical binding]; other site 1232724009604 oxyanion hole (OAH) forming residues; other site 1232724009605 trimer interface [polypeptide binding]; other site 1232724009606 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1232724009607 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1232724009608 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1232724009609 catalytic site [active] 1232724009610 putative active site [active] 1232724009611 putative substrate binding site [chemical binding]; other site 1232724009612 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1232724009613 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1232724009614 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1232724009615 TPP-binding site; other site 1232724009616 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1232724009617 PYR/PP interface [polypeptide binding]; other site 1232724009618 dimer interface [polypeptide binding]; other site 1232724009619 TPP binding site [chemical binding]; other site 1232724009620 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1232724009621 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1232724009622 FOG: CBS domain [General function prediction only]; Region: COG0517 1232724009623 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1232724009624 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1232724009625 transmembrane helices; other site 1232724009626 TRAM domain; Region: TRAM; pfam01938 1232724009627 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1232724009628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724009629 NAD(P) binding site [chemical binding]; other site 1232724009630 active site 1232724009631 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232724009632 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1232724009633 TrkA-N domain; Region: TrkA_N; pfam02254 1232724009634 TrkA-C domain; Region: TrkA_C; pfam02080 1232724009635 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1232724009636 TrkA-N domain; Region: TrkA_N; pfam02254 1232724009637 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1232724009638 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1232724009639 generic binding surface II; other site 1232724009640 ssDNA binding site; other site 1232724009641 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1232724009642 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1232724009643 trimer interface [polypeptide binding]; other site 1232724009644 active site 1232724009645 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1232724009646 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1232724009647 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232724009648 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232724009649 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1232724009650 active site 1232724009651 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232724009652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724009653 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1232724009654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724009655 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1232724009656 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724009657 DNA binding residues [nucleotide binding] 1232724009658 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1232724009659 homotrimer interaction site [polypeptide binding]; other site 1232724009660 putative active site [active] 1232724009661 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1232724009662 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1232724009663 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1232724009664 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1232724009665 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1232724009666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724009667 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1232724009668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724009669 DNA binding residues [nucleotide binding] 1232724009670 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1232724009671 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1232724009672 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1232724009673 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1232724009674 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1232724009675 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1232724009676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724009677 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724009678 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724009679 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232724009680 PAC2 family; Region: PAC2; pfam09754 1232724009681 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724009682 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1232724009683 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1232724009684 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1232724009685 heme-binding site [chemical binding]; other site 1232724009686 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 1232724009687 ATP cone domain; Region: ATP-cone; pfam03477 1232724009688 LexA repressor; Validated; Region: PRK00215 1232724009689 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1232724009690 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1232724009691 Catalytic site [active] 1232724009692 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1232724009693 LGFP repeat; Region: LGFP; pfam08310 1232724009694 LGFP repeat; Region: LGFP; pfam08310 1232724009695 LGFP repeat; Region: LGFP; pfam08310 1232724009696 LGFP repeat; Region: LGFP; pfam08310 1232724009697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724009698 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724009699 active site 1232724009700 GTPases [General function prediction only]; Region: HflX; COG2262 1232724009701 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1232724009702 HflX GTPase family; Region: HflX; cd01878 1232724009703 G1 box; other site 1232724009704 GTP/Mg2+ binding site [chemical binding]; other site 1232724009705 Switch I region; other site 1232724009706 G2 box; other site 1232724009707 G3 box; other site 1232724009708 Switch II region; other site 1232724009709 G4 box; other site 1232724009710 G5 box; other site 1232724009711 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1232724009712 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1232724009713 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1232724009714 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1232724009715 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1232724009716 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1232724009717 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1232724009718 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1232724009719 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1232724009720 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1232724009721 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1232724009722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724009723 FeS/SAM binding site; other site 1232724009724 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1232724009725 recombinase A; Provisional; Region: recA; PRK09354 1232724009726 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1232724009727 hexamer interface [polypeptide binding]; other site 1232724009728 Walker A motif; other site 1232724009729 ATP binding site [chemical binding]; other site 1232724009730 Walker B motif; other site 1232724009731 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1232724009732 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1232724009733 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232724009734 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1232724009735 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1232724009736 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232724009737 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 1232724009738 PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674 1232724009739 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1232724009740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724009741 non-specific DNA binding site [nucleotide binding]; other site 1232724009742 salt bridge; other site 1232724009743 sequence-specific DNA binding site [nucleotide binding]; other site 1232724009744 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1232724009745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724009746 Coenzyme A binding pocket [chemical binding]; other site 1232724009747 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1232724009748 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1232724009749 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724009750 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1232724009751 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1232724009752 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1232724009753 classical (c) SDRs; Region: SDR_c; cd05233 1232724009754 NAD(P) binding site [chemical binding]; other site 1232724009755 active site 1232724009756 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724009757 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724009758 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1232724009759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724009760 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1232724009761 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1232724009762 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1232724009763 dimer interface [polypeptide binding]; other site 1232724009764 active site 1232724009765 catalytic residue [active] 1232724009766 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1232724009767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1232724009768 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1232724009769 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1232724009770 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1232724009771 folate binding site [chemical binding]; other site 1232724009772 NADP+ binding site [chemical binding]; other site 1232724009773 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1232724009774 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1232724009775 dimerization interface [polypeptide binding]; other site 1232724009776 active site 1232724009777 Dienelactone hydrolase family; Region: DLH; pfam01738 1232724009778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724009779 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724009780 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724009781 active site 1232724009782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724009783 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724009784 active site 1232724009785 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1232724009786 classical (c) SDRs; Region: SDR_c; cd05233 1232724009787 NAD(P) binding site [chemical binding]; other site 1232724009788 active site 1232724009789 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1232724009790 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232724009791 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724009792 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232724009793 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1232724009794 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232724009795 carboxyltransferase (CT) interaction site; other site 1232724009796 biotinylation site [posttranslational modification]; other site 1232724009797 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232724009798 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724009799 frameshift; 4-coumarate--CoA ligase 3 1232724009800 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1232724009801 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724009802 CoenzymeA binding site [chemical binding]; other site 1232724009803 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1232724009804 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232724009805 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1232724009806 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1232724009807 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1232724009808 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724009809 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1232724009810 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724009811 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724009812 [2Fe-2S] cluster binding site [ion binding]; other site 1232724009813 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1232724009814 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232724009815 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1232724009816 FMN-binding pocket [chemical binding]; other site 1232724009817 flavin binding motif; other site 1232724009818 phosphate binding motif [ion binding]; other site 1232724009819 beta-alpha-beta structure motif; other site 1232724009820 NAD binding pocket [chemical binding]; other site 1232724009821 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724009822 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1232724009823 catalytic loop [active] 1232724009824 iron binding site [ion binding]; other site 1232724009825 short chain dehydrogenase; Validated; Region: PRK05855 1232724009826 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724009827 classical (c) SDRs; Region: SDR_c; cd05233 1232724009828 NAD(P) binding site [chemical binding]; other site 1232724009829 active site 1232724009830 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1232724009831 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1232724009832 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724009833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724009834 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724009835 hydrophobic ligand binding site; other site 1232724009836 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1232724009837 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1232724009838 hexamer interface [polypeptide binding]; other site 1232724009839 ligand binding site [chemical binding]; other site 1232724009840 putative active site [active] 1232724009841 NAD(P) binding site [chemical binding]; other site 1232724009842 Nitronate monooxygenase; Region: NMO; pfam03060 1232724009843 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724009844 FMN binding site [chemical binding]; other site 1232724009845 substrate binding site [chemical binding]; other site 1232724009846 putative catalytic residue [active] 1232724009847 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1232724009848 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1232724009849 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1232724009850 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1232724009851 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1232724009852 oligomer interface [polypeptide binding]; other site 1232724009853 RNA binding site [nucleotide binding]; other site 1232724009854 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1232724009855 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1232724009856 RNase E interface [polypeptide binding]; other site 1232724009857 trimer interface [polypeptide binding]; other site 1232724009858 active site 1232724009859 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1232724009860 putative nucleic acid binding region [nucleotide binding]; other site 1232724009861 G-X-X-G motif; other site 1232724009862 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1232724009863 RNA binding site [nucleotide binding]; other site 1232724009864 domain interface; other site 1232724009865 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1232724009866 16S/18S rRNA binding site [nucleotide binding]; other site 1232724009867 S13e-L30e interaction site [polypeptide binding]; other site 1232724009868 25S rRNA binding site [nucleotide binding]; other site 1232724009869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724009870 dimerization interface [polypeptide binding]; other site 1232724009871 putative DNA binding site [nucleotide binding]; other site 1232724009872 putative Zn2+ binding site [ion binding]; other site 1232724009873 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1232724009874 putative hydrophobic ligand binding site [chemical binding]; other site 1232724009875 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1232724009876 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1232724009877 active site 1232724009878 Riboflavin kinase; Region: Flavokinase; pfam01687 1232724009879 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1232724009880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724009881 putative DNA binding site [nucleotide binding]; other site 1232724009882 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1232724009883 FeoA domain; Region: FeoA; pfam04023 1232724009884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724009885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724009886 active site 1232724009887 lipid-transfer protein; Provisional; Region: PRK08256 1232724009888 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724009889 active site 1232724009890 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1232724009891 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1232724009892 RNA binding site [nucleotide binding]; other site 1232724009893 active site 1232724009894 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1232724009895 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1232724009896 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1232724009897 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1232724009898 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232724009899 active site 1232724009900 metal binding site [ion binding]; metal-binding site 1232724009901 Predicted acyl esterases [General function prediction only]; Region: COG2936 1232724009902 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1232724009903 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1232724009904 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1232724009905 enoyl-CoA hydratase; Provisional; Region: PRK06190 1232724009906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724009907 substrate binding site [chemical binding]; other site 1232724009908 oxyanion hole (OAH) forming residues; other site 1232724009909 trimer interface [polypeptide binding]; other site 1232724009910 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1232724009911 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1232724009912 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1232724009913 DHH family; Region: DHH; pfam01368 1232724009914 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1232724009915 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1232724009916 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1232724009917 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1232724009918 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1232724009919 G1 box; other site 1232724009920 putative GEF interaction site [polypeptide binding]; other site 1232724009921 GTP/Mg2+ binding site [chemical binding]; other site 1232724009922 Switch I region; other site 1232724009923 G2 box; other site 1232724009924 G3 box; other site 1232724009925 Switch II region; other site 1232724009926 G4 box; other site 1232724009927 G5 box; other site 1232724009928 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1232724009929 Translation-initiation factor 2; Region: IF-2; pfam11987 1232724009930 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1232724009931 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1232724009932 putative RNA binding cleft [nucleotide binding]; other site 1232724009933 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1232724009934 NusA N-terminal domain; Region: NusA_N; pfam08529 1232724009935 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1232724009936 RNA binding site [nucleotide binding]; other site 1232724009937 homodimer interface [polypeptide binding]; other site 1232724009938 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1232724009939 G-X-X-G motif; other site 1232724009940 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1232724009941 G-X-X-G motif; other site 1232724009942 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1232724009943 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1232724009944 putative oligomer interface [polypeptide binding]; other site 1232724009945 putative RNA binding site [nucleotide binding]; other site 1232724009946 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1232724009947 dinuclear metal binding motif [ion binding]; other site 1232724009948 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1232724009949 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232724009950 motif 1; other site 1232724009951 dimer interface [polypeptide binding]; other site 1232724009952 active site 1232724009953 motif 2; other site 1232724009954 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1232724009955 putative deacylase active site [active] 1232724009956 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232724009957 active site 1232724009958 motif 3; other site 1232724009959 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1232724009960 anticodon binding site; other site 1232724009961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724009962 putative substrate translocation pore; other site 1232724009963 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1232724009964 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1232724009965 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1232724009966 active site 1232724009967 SAM binding site [chemical binding]; other site 1232724009968 homodimer interface [polypeptide binding]; other site 1232724009969 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1232724009970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232724009971 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1232724009972 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1232724009973 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1232724009974 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1232724009975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1232724009976 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1232724009977 metal ion-dependent adhesion site (MIDAS); other site 1232724009978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724009979 Coenzyme A binding pocket [chemical binding]; other site 1232724009980 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1232724009981 malate:quinone oxidoreductase; Validated; Region: PRK05257 1232724009982 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1232724009983 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724009984 mycothione reductase; Reviewed; Region: PRK07846 1232724009985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724009986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724009987 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724009988 ferric uptake regulator; Provisional; Region: fur; PRK09462 1232724009989 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1232724009990 metal binding site 2 [ion binding]; metal-binding site 1232724009991 putative DNA binding helix; other site 1232724009992 metal binding site 1 [ion binding]; metal-binding site 1232724009993 dimer interface [polypeptide binding]; other site 1232724009994 structural Zn2+ binding site [ion binding]; other site 1232724009995 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1232724009996 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1232724009997 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1232724009998 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232724009999 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1232724010000 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1232724010001 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1232724010002 NifU-like domain; Region: NifU; cl00484 1232724010003 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 1232724010004 nickel binding site [ion binding]; other site 1232724010005 HupF/HypC family; Region: HupF_HypC; pfam01455 1232724010006 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1232724010007 Acylphosphatase; Region: Acylphosphatase; pfam00708 1232724010008 HypF finger; Region: zf-HYPF; pfam07503 1232724010009 HypF finger; Region: zf-HYPF; pfam07503 1232724010010 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1232724010011 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1232724010012 HupF/HypC family; Region: HupF_HypC; cl00394 1232724010013 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1232724010014 active site 1232724010015 dimer interface [polypeptide binding]; other site 1232724010016 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1232724010017 dimerization interface [polypeptide binding]; other site 1232724010018 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1232724010019 ATP binding site [chemical binding]; other site 1232724010020 HupF/HypC family; Region: HupF_HypC; pfam01455 1232724010021 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1232724010022 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1232724010023 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1232724010024 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1232724010025 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724010026 PPE family; Region: PPE; pfam00823 1232724010027 short chain dehydrogenase; Provisional; Region: PRK06057 1232724010028 classical (c) SDRs; Region: SDR_c; cd05233 1232724010029 NAD(P) binding site [chemical binding]; other site 1232724010030 active site 1232724010031 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724010032 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232724010033 NAD(P) binding site [chemical binding]; other site 1232724010034 catalytic residues [active] 1232724010035 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1232724010036 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1232724010037 catalytic triad [active] 1232724010038 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1232724010039 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1232724010040 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724010041 cobyric acid synthase; Provisional; Region: PRK00784 1232724010042 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1232724010043 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1232724010044 catalytic triad [active] 1232724010045 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1232724010046 active site 1232724010047 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1232724010048 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1232724010049 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1232724010050 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232724010051 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1232724010052 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1232724010053 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1232724010054 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1232724010055 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1232724010056 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1232724010057 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1232724010058 active site 1232724010059 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1232724010060 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1232724010061 putative substrate binding region [chemical binding]; other site 1232724010062 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1232724010063 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1232724010064 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1232724010065 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1232724010066 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1232724010067 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1232724010068 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232724010069 catalytic residues [active] 1232724010070 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1232724010071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724010072 FeS/SAM binding site; other site 1232724010073 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1232724010074 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1232724010075 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1232724010076 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1232724010077 hinge region; other site 1232724010078 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1232724010079 putative nucleotide binding site [chemical binding]; other site 1232724010080 uridine monophosphate binding site [chemical binding]; other site 1232724010081 homohexameric interface [polypeptide binding]; other site 1232724010082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724010083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724010084 DNA binding site [nucleotide binding] 1232724010085 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724010086 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1232724010087 putative acyl-acceptor binding pocket; other site 1232724010088 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1232724010089 short chain dehydrogenase; Provisional; Region: PRK06701 1232724010090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724010091 NAD(P) binding site [chemical binding]; other site 1232724010092 active site 1232724010093 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1232724010094 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1232724010095 Moco binding site; other site 1232724010096 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1232724010097 metal coordination site [ion binding]; other site 1232724010098 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1232724010099 ChaB; Region: ChaB; pfam06150 1232724010100 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1232724010101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724010102 MarR family; Region: MarR; pfam01047 1232724010103 amidase; Provisional; Region: PRK07869 1232724010104 Amidase; Region: Amidase; pfam01425 1232724010105 elongation factor Ts; Provisional; Region: tsf; PRK09377 1232724010106 UBA/TS-N domain; Region: UBA; pfam00627 1232724010107 Elongation factor TS; Region: EF_TS; pfam00889 1232724010108 Elongation factor TS; Region: EF_TS; pfam00889 1232724010109 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1232724010110 rRNA interaction site [nucleotide binding]; other site 1232724010111 S8 interaction site; other site 1232724010112 putative laminin-1 binding site; other site 1232724010113 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1232724010114 Peptidase family M23; Region: Peptidase_M23; pfam01551 1232724010115 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1232724010116 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232724010117 active site 1232724010118 DNA binding site [nucleotide binding] 1232724010119 Int/Topo IB signature motif; other site 1232724010120 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1232724010121 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1232724010122 putative active site [active] 1232724010123 putative substrate binding site [chemical binding]; other site 1232724010124 putative FMN binding site [chemical binding]; other site 1232724010125 putative catalytic residues [active] 1232724010126 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1232724010127 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1232724010128 FAD binding pocket [chemical binding]; other site 1232724010129 FAD binding motif [chemical binding]; other site 1232724010130 phosphate binding motif [ion binding]; other site 1232724010131 NAD binding pocket [chemical binding]; other site 1232724010132 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1232724010133 DNA protecting protein DprA; Region: dprA; TIGR00732 1232724010134 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1232724010135 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1232724010136 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1232724010137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724010138 Walker A motif; other site 1232724010139 ATP binding site [chemical binding]; other site 1232724010140 Walker B motif; other site 1232724010141 arginine finger; other site 1232724010142 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1232724010143 hypothetical protein; Reviewed; Region: PRK12497 1232724010144 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1232724010145 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1232724010146 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1232724010147 putative molybdopterin cofactor binding site [chemical binding]; other site 1232724010148 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1232724010149 putative molybdopterin cofactor binding site; other site 1232724010150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724010151 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1232724010152 NAD(P) binding site [chemical binding]; other site 1232724010153 active site 1232724010154 ANTAR domain; Region: ANTAR; pfam03861 1232724010155 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1232724010156 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1232724010157 RNA/DNA hybrid binding site [nucleotide binding]; other site 1232724010158 active site 1232724010159 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1232724010160 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1232724010161 Catalytic site [active] 1232724010162 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1232724010163 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1232724010164 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1232724010165 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1232724010166 RimM N-terminal domain; Region: RimM; pfam01782 1232724010167 PRC-barrel domain; Region: PRC; pfam05239 1232724010168 hypothetical protein; Provisional; Region: PRK02821 1232724010169 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1232724010170 G-X-X-G motif; other site 1232724010171 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1232724010172 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724010173 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1232724010174 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1232724010175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724010177 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724010178 active site 1232724010179 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1232724010180 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724010181 active site 1232724010182 signal recognition particle protein; Provisional; Region: PRK10867 1232724010183 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1232724010184 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1232724010185 P loop; other site 1232724010186 GTP binding site [chemical binding]; other site 1232724010187 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1232724010188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724010189 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1232724010190 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232724010191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724010192 ATP binding site [chemical binding]; other site 1232724010193 putative Mg++ binding site [ion binding]; other site 1232724010194 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724010195 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1232724010196 active site 1232724010197 PII uridylyl-transferase; Provisional; Region: PRK03381 1232724010198 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1232724010199 metal binding triad; other site 1232724010200 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1232724010201 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1232724010202 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1232724010203 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1232724010204 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1232724010205 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1232724010206 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1232724010207 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1232724010208 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1232724010209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232724010210 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1232724010211 AAA domain; Region: AAA_23; pfam13476 1232724010212 Walker A/P-loop; other site 1232724010213 ATP binding site [chemical binding]; other site 1232724010214 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1232724010215 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1232724010216 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1232724010217 ABC transporter signature motif; other site 1232724010218 Walker B; other site 1232724010219 D-loop; other site 1232724010220 H-loop/switch region; other site 1232724010221 acylphosphatase; Provisional; Region: PRK14422 1232724010222 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1232724010223 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1232724010224 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1232724010225 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1232724010226 DNA binding site [nucleotide binding] 1232724010227 catalytic residue [active] 1232724010228 H2TH interface [polypeptide binding]; other site 1232724010229 putative catalytic residues [active] 1232724010230 turnover-facilitating residue; other site 1232724010231 intercalation triad [nucleotide binding]; other site 1232724010232 8OG recognition residue [nucleotide binding]; other site 1232724010233 putative reading head residues; other site 1232724010234 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232724010235 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232724010236 ribonuclease III; Reviewed; Region: rnc; PRK00102 1232724010237 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1232724010238 dimerization interface [polypeptide binding]; other site 1232724010239 active site 1232724010240 metal binding site [ion binding]; metal-binding site 1232724010241 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1232724010242 dsRNA binding site [nucleotide binding]; other site 1232724010243 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1232724010244 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1232724010245 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1232724010246 Predicted permease; Region: DUF318; pfam03773 1232724010247 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1232724010248 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232724010249 PYR/PP interface [polypeptide binding]; other site 1232724010250 dimer interface [polypeptide binding]; other site 1232724010251 TPP binding site [chemical binding]; other site 1232724010252 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724010253 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1232724010254 TPP-binding site [chemical binding]; other site 1232724010255 dimer interface [polypeptide binding]; other site 1232724010256 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1232724010257 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1232724010258 active site 1232724010259 (T/H)XGH motif; other site 1232724010260 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1232724010261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724010262 S-adenosylmethionine binding site [chemical binding]; other site 1232724010263 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1232724010264 putative active site [active] 1232724010265 redox center [active] 1232724010266 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1232724010267 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1232724010268 catalytic residues [active] 1232724010269 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724010270 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724010271 substrate binding pocket [chemical binding]; other site 1232724010272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724010273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724010274 active site 1232724010275 catalytic tetrad [active] 1232724010276 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1232724010277 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1232724010278 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1232724010279 ssDNA binding site; other site 1232724010280 generic binding surface II; other site 1232724010281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724010282 ATP binding site [chemical binding]; other site 1232724010283 putative Mg++ binding site [ion binding]; other site 1232724010284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724010285 nucleotide binding region [chemical binding]; other site 1232724010286 ATP-binding site [chemical binding]; other site 1232724010287 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1232724010288 DAK2 domain; Region: Dak2; cl03685 1232724010289 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1232724010290 catalytic residue [active] 1232724010291 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1232724010292 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724010293 classical (c) SDRs; Region: SDR_c; cd05233 1232724010294 NAD(P) binding site [chemical binding]; other site 1232724010295 active site 1232724010296 short chain dehydrogenase; Provisional; Region: PRK06197 1232724010297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724010298 NAD(P) binding site [chemical binding]; other site 1232724010299 active site 1232724010300 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724010301 short chain dehydrogenase; Provisional; Region: PRK06180 1232724010302 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1232724010303 NADP binding site [chemical binding]; other site 1232724010304 active site 1232724010305 steroid binding site; other site 1232724010306 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232724010307 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1232724010308 putative NAD(P) binding site [chemical binding]; other site 1232724010309 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1232724010310 ligand binding site [chemical binding]; other site 1232724010311 active site 1232724010312 UGI interface [polypeptide binding]; other site 1232724010313 catalytic site [active] 1232724010314 thiamine monophosphate kinase; Provisional; Region: PRK05731 1232724010315 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1232724010316 ATP binding site [chemical binding]; other site 1232724010317 dimerization interface [polypeptide binding]; other site 1232724010318 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1232724010319 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1232724010320 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1232724010321 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1232724010322 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1232724010323 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1232724010324 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1232724010325 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1232724010326 polyphosphate kinase; Provisional; Region: PRK05443 1232724010327 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1232724010328 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1232724010329 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1232724010330 putative domain interface [polypeptide binding]; other site 1232724010331 putative active site [active] 1232724010332 catalytic site [active] 1232724010333 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1232724010334 putative domain interface [polypeptide binding]; other site 1232724010335 putative active site [active] 1232724010336 catalytic site [active] 1232724010337 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1232724010338 active site 1232724010339 Ap6A binding site [chemical binding]; other site 1232724010340 nudix motif; other site 1232724010341 metal binding site [ion binding]; metal-binding site 1232724010342 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724010343 catalytic core [active] 1232724010344 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1232724010345 IHF - DNA interface [nucleotide binding]; other site 1232724010346 IHF dimer interface [polypeptide binding]; other site 1232724010347 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1232724010348 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1232724010349 substrate binding site [chemical binding]; other site 1232724010350 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1232724010351 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1232724010352 substrate binding site [chemical binding]; other site 1232724010353 ligand binding site [chemical binding]; other site 1232724010354 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232724010355 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1232724010356 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232724010357 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1232724010358 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1232724010359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232724010360 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1232724010361 active site 1232724010362 KMSKS motif; other site 1232724010363 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1232724010364 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1232724010365 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1232724010366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724010367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232724010368 putative substrate translocation pore; other site 1232724010369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724010370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232724010371 putative substrate translocation pore; other site 1232724010372 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1232724010373 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1232724010374 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1232724010375 ligand binding site [chemical binding]; other site 1232724010376 NAD binding site [chemical binding]; other site 1232724010377 dimerization interface [polypeptide binding]; other site 1232724010378 catalytic site [active] 1232724010379 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1232724010380 putative L-serine binding site [chemical binding]; other site 1232724010381 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1232724010382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724010383 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1232724010384 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232724010385 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1232724010386 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1232724010387 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1232724010388 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1232724010389 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1232724010390 putative valine binding site [chemical binding]; other site 1232724010391 dimer interface [polypeptide binding]; other site 1232724010392 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1232724010393 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1232724010394 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232724010395 PYR/PP interface [polypeptide binding]; other site 1232724010396 dimer interface [polypeptide binding]; other site 1232724010397 TPP binding site [chemical binding]; other site 1232724010398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724010399 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1232724010400 TPP-binding site [chemical binding]; other site 1232724010401 dimer interface [polypeptide binding]; other site 1232724010402 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1232724010403 Predicted membrane protein [Function unknown]; Region: COG2259 1232724010404 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1232724010405 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1232724010406 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1232724010407 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1232724010408 GatB domain; Region: GatB_Yqey; smart00845 1232724010409 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232724010410 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1232724010411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232724010412 P-loop; other site 1232724010413 Magnesium ion binding site [ion binding]; other site 1232724010414 6-phosphofructokinase; Provisional; Region: PRK03202 1232724010415 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1232724010416 active site 1232724010417 ADP/pyrophosphate binding site [chemical binding]; other site 1232724010418 dimerization interface [polypeptide binding]; other site 1232724010419 allosteric effector site; other site 1232724010420 fructose-1,6-bisphosphate binding site; other site 1232724010421 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1232724010422 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1232724010423 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1232724010424 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1232724010425 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724010426 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724010427 active site 1232724010428 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1232724010429 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724010430 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1232724010431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724010433 cystathionine gamma-lyase; Validated; Region: PRK07582 1232724010434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1232724010435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724010436 catalytic residue [active] 1232724010437 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1232724010438 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1232724010439 nucleotide binding pocket [chemical binding]; other site 1232724010440 K-X-D-G motif; other site 1232724010441 catalytic site [active] 1232724010442 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1232724010443 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1232724010444 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1232724010445 Dimer interface [polypeptide binding]; other site 1232724010446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232724010447 putative DNA binding site [nucleotide binding]; other site 1232724010448 putative Zn2+ binding site [ion binding]; other site 1232724010449 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1232724010450 putative hydrophobic ligand binding site [chemical binding]; other site 1232724010451 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1232724010452 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724010453 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1232724010454 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1232724010455 Ligand Binding Site [chemical binding]; other site 1232724010456 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1232724010457 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1232724010458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724010459 catalytic residue [active] 1232724010460 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724010461 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232724010462 putative acyl-acceptor binding pocket; other site 1232724010463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1232724010464 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1232724010465 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1232724010466 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1232724010467 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1232724010468 Ligand binding site [chemical binding]; other site 1232724010469 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1232724010470 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232724010471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724010472 S-adenosylmethionine binding site [chemical binding]; other site 1232724010473 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1232724010474 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1232724010475 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1232724010476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724010477 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724010478 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1232724010479 putative hydrophobic ligand binding site [chemical binding]; other site 1232724010480 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1232724010481 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1232724010482 putative NAD(P) binding site [chemical binding]; other site 1232724010483 putative active site [active] 1232724010484 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724010485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724010486 NAD(P) binding site [chemical binding]; other site 1232724010487 active site 1232724010488 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724010489 anti sigma factor interaction site; other site 1232724010490 regulatory phosphorylation site [posttranslational modification]; other site 1232724010491 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232724010492 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232724010493 substrate binding pocket [chemical binding]; other site 1232724010494 chain length determination region; other site 1232724010495 substrate-Mg2+ binding site; other site 1232724010496 catalytic residues [active] 1232724010497 aspartate-rich region 1; other site 1232724010498 active site lid residues [active] 1232724010499 aspartate-rich region 2; other site 1232724010500 phytoene desaturase; Region: crtI_fam; TIGR02734 1232724010501 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1232724010502 active site lid residues [active] 1232724010503 substrate binding pocket [chemical binding]; other site 1232724010504 catalytic residues [active] 1232724010505 substrate-Mg2+ binding site; other site 1232724010506 aspartate-rich region 1; other site 1232724010507 aspartate-rich region 2; other site 1232724010508 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1232724010509 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1232724010510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724010511 S-adenosylmethionine binding site [chemical binding]; other site 1232724010512 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1232724010513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724010514 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1232724010515 [2Fe-2S] cluster binding site [ion binding]; other site 1232724010516 iron-sulfur cluster [ion binding]; other site 1232724010517 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1232724010518 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1232724010519 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232724010520 MarR family; Region: MarR_2; pfam12802 1232724010521 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1232724010522 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1232724010523 active site 1232724010524 TDP-binding site; other site 1232724010525 acceptor substrate-binding pocket; other site 1232724010526 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1232724010527 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1232724010528 homotetramer interface [polypeptide binding]; other site 1232724010529 FMN binding site [chemical binding]; other site 1232724010530 homodimer contacts [polypeptide binding]; other site 1232724010531 putative active site [active] 1232724010532 putative substrate binding site [chemical binding]; other site 1232724010533 MMPL family; Region: MMPL; pfam03176 1232724010534 TspO/MBR family; Region: TspO_MBR; pfam03073 1232724010535 DNA photolyase; Region: DNA_photolyase; pfam00875 1232724010536 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1232724010537 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1232724010538 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1232724010539 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1232724010540 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1232724010541 trimer interface [polypeptide binding]; other site 1232724010542 active site 1232724010543 substrate binding site [chemical binding]; other site 1232724010544 CoA binding site [chemical binding]; other site 1232724010545 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1232724010546 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1232724010547 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1232724010548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724010549 S-adenosylmethionine binding site [chemical binding]; other site 1232724010550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724010551 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724010552 substrate binding site [chemical binding]; other site 1232724010553 oxyanion hole (OAH) forming residues; other site 1232724010554 trimer interface [polypeptide binding]; other site 1232724010555 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1232724010556 nudix motif; other site 1232724010557 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1232724010558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724010559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724010560 Walker A/P-loop; other site 1232724010561 Walker A/P-loop; other site 1232724010562 ATP binding site [chemical binding]; other site 1232724010563 ATP binding site [chemical binding]; other site 1232724010564 Q-loop/lid; other site 1232724010565 ABC transporter signature motif; other site 1232724010566 Walker B; other site 1232724010567 D-loop; other site 1232724010568 H-loop/switch region; other site 1232724010569 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1232724010570 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1232724010571 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1232724010572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724010573 motif II; other site 1232724010574 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1232724010575 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1232724010576 D-pathway; other site 1232724010577 Putative ubiquinol binding site [chemical binding]; other site 1232724010578 Low-spin heme (heme b) binding site [chemical binding]; other site 1232724010579 Putative water exit pathway; other site 1232724010580 Binuclear center (heme o3/CuB) [ion binding]; other site 1232724010581 K-pathway; other site 1232724010582 Putative proton exit pathway; other site 1232724010583 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1232724010584 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232724010585 siderophore binding site; other site 1232724010586 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1232724010587 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1232724010588 putative NAD(P) binding site [chemical binding]; other site 1232724010589 putative substrate binding site [chemical binding]; other site 1232724010590 catalytic Zn binding site [ion binding]; other site 1232724010591 structural Zn binding site [ion binding]; other site 1232724010592 dimer interface [polypeptide binding]; other site 1232724010593 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1232724010594 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1232724010595 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1232724010596 dimer interface [polypeptide binding]; other site 1232724010597 putative radical transfer pathway; other site 1232724010598 diiron center [ion binding]; other site 1232724010599 tyrosyl radical; other site 1232724010600 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1232724010601 putative hydrophobic ligand binding site [chemical binding]; other site 1232724010602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724010604 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232724010605 Ligand Binding Site [chemical binding]; other site 1232724010606 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724010607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724010608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724010610 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232724010611 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1232724010612 putative dimer interface [polypeptide binding]; other site 1232724010613 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724010614 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1232724010615 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1232724010616 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1232724010617 active site 1232724010618 dimer interface [polypeptide binding]; other site 1232724010619 catalytic residues [active] 1232724010620 effector binding site; other site 1232724010621 R2 peptide binding site; other site 1232724010622 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1232724010623 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1232724010624 catalytic residues [active] 1232724010625 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232724010626 Predicted flavoprotein [General function prediction only]; Region: COG0431 1232724010627 short chain dehydrogenase; Provisional; Region: PRK07832 1232724010628 classical (c) SDRs; Region: SDR_c; cd05233 1232724010629 NAD(P) binding site [chemical binding]; other site 1232724010630 active site 1232724010631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724010633 Cytochrome P450; Region: p450; cl12078 1232724010634 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724010635 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1232724010636 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1232724010637 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1232724010638 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1232724010639 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232724010640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724010641 DNA-binding site [nucleotide binding]; DNA binding site 1232724010642 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1232724010643 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1232724010644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1232724010645 DNA-binding site [nucleotide binding]; DNA binding site 1232724010646 FCD domain; Region: FCD; pfam07729 1232724010647 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724010648 active site 1232724010649 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724010650 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724010651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724010652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724010653 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724010654 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724010655 active site 1232724010656 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1232724010657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724010658 NAD(P) binding site [chemical binding]; other site 1232724010659 active site 1232724010660 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1232724010661 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1232724010662 active site 1232724010663 DNA binding site [nucleotide binding] 1232724010664 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1232724010665 DNA binding site [nucleotide binding] 1232724010666 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1232724010667 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1232724010668 nucleotide binding site [chemical binding]; other site 1232724010669 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1232724010670 SBD interface [polypeptide binding]; other site 1232724010671 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1232724010672 FMN binding site [chemical binding]; other site 1232724010673 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1232724010674 dimer interface [polypeptide binding]; other site 1232724010675 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724010676 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1232724010677 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724010678 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1232724010679 dimer interface [polypeptide binding]; other site 1232724010680 active site 1232724010681 enoyl-CoA hydratase; Provisional; Region: PRK05864 1232724010682 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724010683 substrate binding site [chemical binding]; other site 1232724010684 oxyanion hole (OAH) forming residues; other site 1232724010685 trimer interface [polypeptide binding]; other site 1232724010686 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724010687 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724010688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724010689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724010690 active site 1232724010691 MspA; Region: MspA; pfam09203 1232724010692 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724010693 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724010694 putative active site [active] 1232724010695 putative substrate binding site [chemical binding]; other site 1232724010696 ATP binding site [chemical binding]; other site 1232724010697 short chain dehydrogenase; Provisional; Region: PRK08278 1232724010698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724010699 NAD(P) binding site [chemical binding]; other site 1232724010700 active site 1232724010701 Predicted membrane protein [Function unknown]; Region: COG2259 1232724010702 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724010703 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1232724010704 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724010705 Transport protein; Region: actII; TIGR00833 1232724010706 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724010707 classical (c) SDRs; Region: SDR_c; cd05233 1232724010708 NAD(P) binding site [chemical binding]; other site 1232724010709 active site 1232724010710 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724010711 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1232724010712 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1232724010713 substrate binding pocket [chemical binding]; other site 1232724010714 active site 1232724010715 iron coordination sites [ion binding]; other site 1232724010716 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724010717 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724010718 [2Fe-2S] cluster binding site [ion binding]; other site 1232724010719 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1232724010720 alpha subunit interface [polypeptide binding]; other site 1232724010721 active site 1232724010722 substrate binding site [chemical binding]; other site 1232724010723 Fe binding site [ion binding]; other site 1232724010724 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724010725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724010726 NAD(P) binding site [chemical binding]; other site 1232724010727 active site 1232724010728 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1232724010729 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1232724010730 FAD binding pocket [chemical binding]; other site 1232724010731 FAD binding motif [chemical binding]; other site 1232724010732 phosphate binding motif [ion binding]; other site 1232724010733 beta-alpha-beta structure motif; other site 1232724010734 NAD(p) ribose binding residues [chemical binding]; other site 1232724010735 NAD binding pocket [chemical binding]; other site 1232724010736 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1232724010737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724010738 catalytic loop [active] 1232724010739 iron binding site [ion binding]; other site 1232724010740 MarR family; Region: MarR_2; pfam12802 1232724010741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724010742 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1232724010743 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1232724010744 active site 1232724010745 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724010746 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724010747 [2Fe-2S] cluster binding site [ion binding]; other site 1232724010748 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1232724010749 alpha subunit interface [polypeptide binding]; other site 1232724010750 active site 1232724010751 substrate binding site [chemical binding]; other site 1232724010752 Fe binding site [ion binding]; other site 1232724010753 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724010754 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1232724010755 NAD binding site [chemical binding]; other site 1232724010756 catalytic residues [active] 1232724010757 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1232724010758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724010759 acyl-activating enzyme (AAE) consensus motif; other site 1232724010760 AMP binding site [chemical binding]; other site 1232724010761 active site 1232724010762 CoA binding site [chemical binding]; other site 1232724010763 Fic/DOC family; Region: Fic; cl00960 1232724010764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724010765 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1232724010766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724010767 phosphoglucomutase; Validated; Region: PRK07564 1232724010768 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1232724010769 active site 1232724010770 substrate binding site [chemical binding]; other site 1232724010771 metal binding site [ion binding]; metal-binding site 1232724010772 camphor resistance protein CrcB; Provisional; Region: PRK14216 1232724010773 camphor resistance protein CrcB; Provisional; Region: PRK14228 1232724010774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1232724010775 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1232724010776 Protein of unknown function, DUF488; Region: DUF488; cl01246 1232724010777 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724010778 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724010779 active site 1232724010780 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1232724010781 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724010782 Fe binding site [ion binding]; other site 1232724010783 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1232724010784 hypothetical protein; Validated; Region: PRK00029 1232724010785 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724010786 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724010787 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1232724010788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010789 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1232724010790 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724010791 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1232724010792 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1232724010793 putative active site [active] 1232724010794 catalytic site [active] 1232724010795 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1232724010796 putative active site [active] 1232724010797 catalytic site [active] 1232724010798 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1232724010799 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1232724010800 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724010801 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1232724010802 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724010803 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1232724010804 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1232724010805 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724010806 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724010807 [2Fe-2S] cluster binding site [ion binding]; other site 1232724010808 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1232724010809 alpha subunit interface [polypeptide binding]; other site 1232724010810 active site 1232724010811 substrate binding site [chemical binding]; other site 1232724010812 Fe binding site [ion binding]; other site 1232724010813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232724010814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724010815 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1232724010816 putative effector binding pocket; other site 1232724010817 dimerization interface [polypeptide binding]; other site 1232724010818 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724010819 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724010820 phosphopeptide binding site; other site 1232724010821 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724010822 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724010823 phosphopeptide binding site; other site 1232724010824 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1232724010825 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1232724010826 Walker A/P-loop; other site 1232724010827 ATP binding site [chemical binding]; other site 1232724010828 Q-loop/lid; other site 1232724010829 ABC transporter signature motif; other site 1232724010830 Walker B; other site 1232724010831 D-loop; other site 1232724010832 H-loop/switch region; other site 1232724010833 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1232724010834 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724010835 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724010836 active site 1232724010837 ATP binding site [chemical binding]; other site 1232724010838 substrate binding site [chemical binding]; other site 1232724010839 activation loop (A-loop); other site 1232724010840 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1232724010841 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1232724010842 Kelch domain; Region: Kelch; smart00612 1232724010843 Kelch motif; Region: Kelch_1; pfam01344 1232724010844 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1232724010845 Kelch motif; Region: Kelch_1; pfam01344 1232724010846 Kelch domain; Region: Kelch; smart00612 1232724010847 Kelch motif; Region: Kelch_6; pfam13964 1232724010848 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1232724010849 Kelch motif; Region: Kelch_1; pfam01344 1232724010850 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724010851 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1232724010852 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1232724010853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1232724010854 transposase/IS protein; Provisional; Region: PRK09183 1232724010855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724010856 Walker A motif; other site 1232724010857 ATP binding site [chemical binding]; other site 1232724010858 Walker B motif; other site 1232724010859 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1232724010860 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724010861 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724010862 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724010863 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724010864 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1232724010865 Enoylreductase; Region: PKS_ER; smart00829 1232724010866 putative NAD(P) binding site [chemical binding]; other site 1232724010867 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724010868 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724010869 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724010870 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1232724010871 molybdopterin cofactor binding site; other site 1232724010872 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1232724010873 putative molybdopterin cofactor binding site; other site 1232724010874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724010876 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724010877 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724010878 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1232724010879 SmpB-tmRNA interface; other site 1232724010880 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1232724010881 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1232724010882 FtsX-like permease family; Region: FtsX; pfam02687 1232724010883 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1232724010884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232724010885 Walker A/P-loop; other site 1232724010886 ATP binding site [chemical binding]; other site 1232724010887 Q-loop/lid; other site 1232724010888 ABC transporter signature motif; other site 1232724010889 Walker B; other site 1232724010890 D-loop; other site 1232724010891 H-loop/switch region; other site 1232724010892 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1232724010893 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232724010894 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1232724010895 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1232724010896 RF-1 domain; Region: RF-1; pfam00472 1232724010897 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1232724010898 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1232724010899 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1232724010900 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1232724010901 Binuclear center (active site) [active] 1232724010902 K-pathway; other site 1232724010903 Putative proton exit pathway; other site 1232724010904 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1232724010905 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1232724010906 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1232724010907 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724010908 PPE family; Region: PPE; pfam00823 1232724010909 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724010910 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724010911 PPE family; Region: PPE; pfam00823 1232724010912 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724010913 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1232724010914 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232724010915 active site 1232724010916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724010917 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724010918 active site 1232724010919 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724010920 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724010921 active site 1232724010922 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724010923 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724010924 active site 1232724010925 catalytic tetrad [active] 1232724010926 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1232724010927 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1232724010928 NADP binding site [chemical binding]; other site 1232724010929 dimer interface [polypeptide binding]; other site 1232724010930 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232724010931 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1232724010932 NAD(P) binding site [chemical binding]; other site 1232724010933 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1232724010934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724010935 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1232724010936 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724010937 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724010938 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1232724010939 active site 1232724010940 catalytic residues [active] 1232724010941 metal binding site [ion binding]; metal-binding site 1232724010942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724010943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724010944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724010945 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724010946 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724010947 active site 1232724010948 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724010949 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724010950 putative active site [active] 1232724010951 putative substrate binding site [chemical binding]; other site 1232724010952 ATP binding site [chemical binding]; other site 1232724010953 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724010954 YceI-like domain; Region: YceI; pfam04264 1232724010955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1232724010956 active site 1232724010957 phosphorylation site [posttranslational modification] 1232724010958 intermolecular recognition site; other site 1232724010959 dimerization interface [polypeptide binding]; other site 1232724010960 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1232724010961 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1232724010962 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1232724010963 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1232724010964 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1232724010965 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1232724010966 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1232724010967 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1232724010968 putative dimer interface [polypeptide binding]; other site 1232724010969 [2Fe-2S] cluster binding site [ion binding]; other site 1232724010970 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1232724010971 SLBB domain; Region: SLBB; pfam10531 1232724010972 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1232724010973 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1232724010974 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724010975 catalytic loop [active] 1232724010976 iron binding site [ion binding]; other site 1232724010977 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1232724010978 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724010979 molybdopterin cofactor binding site; other site 1232724010980 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1232724010981 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1232724010982 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1232724010983 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1232724010984 4Fe-4S binding domain; Region: Fer4; pfam00037 1232724010985 4Fe-4S binding domain; Region: Fer4; pfam00037 1232724010986 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1232724010987 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1232724010988 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1232724010989 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1232724010990 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232724010991 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1232724010992 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232724010993 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1232724010994 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232724010995 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1232724010996 Protein of unknown function DUF58; Region: DUF58; pfam01882 1232724010997 MoxR-like ATPases [General function prediction only]; Region: COG0714 1232724010998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724010999 Walker A motif; other site 1232724011000 ATP binding site [chemical binding]; other site 1232724011001 Walker B motif; other site 1232724011002 arginine finger; other site 1232724011003 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1232724011004 classical (c) SDRs; Region: SDR_c; cd05233 1232724011005 NAD(P) binding site [chemical binding]; other site 1232724011006 active site 1232724011007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724011008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724011009 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724011010 putative active site [active] 1232724011011 putative substrate binding site [chemical binding]; other site 1232724011012 ATP binding site [chemical binding]; other site 1232724011013 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724011014 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1232724011015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724011016 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724011017 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724011018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724011019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232724011020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724011021 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232724011022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724011023 frameshift; CheR methyltransferase SAM bindingdomain-containing protein 1232724011024 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1232724011025 CheB methylesterase; Region: CheB_methylest; pfam01339 1232724011026 hydroperoxidase II; Provisional; Region: katE; PRK11249 1232724011027 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1232724011028 tetramer interface [polypeptide binding]; other site 1232724011029 heme binding pocket [chemical binding]; other site 1232724011030 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1232724011031 domain interactions; other site 1232724011032 transcription termination factor Rho; Provisional; Region: PRK12678 1232724011033 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724011034 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1232724011035 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1232724011036 putative catalytic site [active] 1232724011037 putative metal binding site [ion binding]; other site 1232724011038 putative phosphate binding site [ion binding]; other site 1232724011039 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1232724011040 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232724011041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724011042 NAD(P) binding site [chemical binding]; other site 1232724011043 active site 1232724011044 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 1232724011045 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232724011046 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 1232724011047 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1232724011048 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1232724011049 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1232724011050 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1232724011051 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1232724011052 active site 1232724011053 DNA binding site [nucleotide binding] 1232724011054 Int/Topo IB signature motif; other site 1232724011055 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1232724011056 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1232724011057 PYR/PP interface [polypeptide binding]; other site 1232724011058 dimer interface [polypeptide binding]; other site 1232724011059 tetramer interface [polypeptide binding]; other site 1232724011060 TPP binding site [chemical binding]; other site 1232724011061 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724011062 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1232724011063 TPP-binding site [chemical binding]; other site 1232724011064 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1232724011065 Fe-S cluster binding site [ion binding]; other site 1232724011066 active site 1232724011067 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724011068 Fe binding site [ion binding]; other site 1232724011069 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1232724011070 PknH-like extracellular domain; Region: PknH_C; pfam14032 1232724011071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724011072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724011073 active site 1232724011074 catalytic tetrad [active] 1232724011075 classical (c) SDRs; Region: SDR_c; cd05233 1232724011076 NAD(P) binding site [chemical binding]; other site 1232724011077 active site 1232724011078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1232724011079 PAS fold; Region: PAS_3; pfam08447 1232724011080 putative active site [active] 1232724011081 heme pocket [chemical binding]; other site 1232724011082 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1232724011083 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232724011084 metal binding site [ion binding]; metal-binding site 1232724011085 active site 1232724011086 I-site; other site 1232724011087 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1232724011088 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1232724011089 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1232724011090 active site 1232724011091 catalytic site [active] 1232724011092 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1232724011093 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724011094 NAD binding site [chemical binding]; other site 1232724011095 catalytic Zn binding site [ion binding]; other site 1232724011096 structural Zn binding site [ion binding]; other site 1232724011097 GAF domain; Region: GAF_2; pfam13185 1232724011098 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1232724011099 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232724011100 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1232724011101 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1232724011102 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232724011103 DNA binding residues [nucleotide binding] 1232724011104 putative dimer interface [polypeptide binding]; other site 1232724011105 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1232724011106 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1232724011107 putative dimer interface [polypeptide binding]; other site 1232724011108 PAS fold; Region: PAS_3; pfam08447 1232724011109 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1232724011110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232724011111 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724011112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724011113 active site 1232724011114 phosphorylation site [posttranslational modification] 1232724011115 intermolecular recognition site; other site 1232724011116 dimerization interface [polypeptide binding]; other site 1232724011117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724011118 DNA binding residues [nucleotide binding] 1232724011119 dimerization interface [polypeptide binding]; other site 1232724011120 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1232724011121 yiaA/B two helix domain; Region: YiaAB; cl01759 1232724011122 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232724011123 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1232724011124 FMN-binding pocket [chemical binding]; other site 1232724011125 flavin binding motif; other site 1232724011126 phosphate binding motif [ion binding]; other site 1232724011127 beta-alpha-beta structure motif; other site 1232724011128 NAD binding pocket [chemical binding]; other site 1232724011129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724011130 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1232724011131 catalytic loop [active] 1232724011132 iron binding site [ion binding]; other site 1232724011133 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724011134 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1232724011135 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1232724011136 acyl-CoA synthetase; Validated; Region: PRK05850 1232724011137 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1232724011138 acyl-activating enzyme (AAE) consensus motif; other site 1232724011139 active site 1232724011140 thioester reductase domain; Region: Thioester-redct; TIGR01746 1232724011141 Male sterility protein; Region: NAD_binding_4; pfam07993 1232724011142 NAD(P) binding site [chemical binding]; other site 1232724011143 active site 1232724011144 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1232724011145 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1232724011146 short chain dehydrogenase; Provisional; Region: PRK06197 1232724011147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724011148 NAD(P) binding site [chemical binding]; other site 1232724011149 active site 1232724011150 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724011151 mce related protein; Region: MCE; pfam02470 1232724011152 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724011153 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724011154 mce related protein; Region: MCE; pfam02470 1232724011155 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724011156 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1232724011157 catalytic residues [active] 1232724011158 dimer interface [polypeptide binding]; other site 1232724011159 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1232724011160 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1232724011161 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724011162 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724011163 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1232724011164 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1232724011165 Flavoprotein; Region: Flavoprotein; pfam02441 1232724011166 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1232724011167 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1232724011168 dimerization interface [polypeptide binding]; other site 1232724011169 DPS ferroxidase diiron center [ion binding]; other site 1232724011170 ion pore; other site 1232724011171 Helix-turn-helix domain; Region: HTH_18; pfam12833 1232724011172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724011173 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1232724011174 Nitroreductase family; Region: Nitroreductase; pfam00881 1232724011175 FMN binding site [chemical binding]; other site 1232724011176 dimer interface [polypeptide binding]; other site 1232724011177 choline dehydrogenase; Validated; Region: PRK02106 1232724011178 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1232724011179 AAA ATPase domain; Region: AAA_16; pfam13191 1232724011180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724011181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724011182 DNA binding residues [nucleotide binding] 1232724011183 dimerization interface [polypeptide binding]; other site 1232724011184 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1232724011185 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1232724011186 conserved cys residue [active] 1232724011187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724011188 short chain dehydrogenase; Provisional; Region: PRK08219 1232724011189 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1232724011190 NADP binding site [chemical binding]; other site 1232724011191 active site 1232724011192 steroid binding site; other site 1232724011193 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1232724011194 FMN binding site [chemical binding]; other site 1232724011195 dimer interface [polypeptide binding]; other site 1232724011196 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1232724011197 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1232724011198 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1232724011199 conserved cys residue [active] 1232724011200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232724011201 hypothetical protein; Validated; Region: PRK00068 1232724011202 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1232724011203 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1232724011204 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1232724011205 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1232724011206 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1232724011207 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1232724011208 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1232724011209 ABC1 family; Region: ABC1; pfam03109 1232724011210 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1232724011211 active site 1232724011212 ATP binding site [chemical binding]; other site 1232724011213 Transcription factor WhiB; Region: Whib; pfam02467 1232724011214 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1232724011215 Part of AAA domain; Region: AAA_19; pfam13245 1232724011216 Family description; Region: UvrD_C_2; pfam13538 1232724011217 HRDC domain; Region: HRDC; pfam00570 1232724011218 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1232724011219 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1232724011220 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1232724011221 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1232724011222 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1232724011223 putative NADH binding site [chemical binding]; other site 1232724011224 putative active site [active] 1232724011225 nudix motif; other site 1232724011226 putative metal binding site [ion binding]; other site 1232724011227 Ion channel; Region: Ion_trans_2; pfam07885 1232724011228 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1232724011229 TrkA-N domain; Region: TrkA_N; pfam02254 1232724011230 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1232724011231 Part of AAA domain; Region: AAA_19; pfam13245 1232724011232 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1232724011233 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1232724011234 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1232724011235 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1232724011236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724011237 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724011238 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1232724011239 catalytic site [active] 1232724011240 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1232724011241 active site 1232724011242 DNA binding site [nucleotide binding] 1232724011243 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232724011244 TIGR02569 family protein; Region: TIGR02569_actnb 1232724011245 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1232724011246 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1232724011247 ATP binding site [chemical binding]; other site 1232724011248 substrate interface [chemical binding]; other site 1232724011249 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232724011250 active site residue [active] 1232724011251 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1232724011252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724011253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724011254 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1232724011255 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1232724011256 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1232724011257 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1232724011258 ATP binding site [chemical binding]; other site 1232724011259 Mg++ binding site [ion binding]; other site 1232724011260 motif III; other site 1232724011261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724011262 nucleotide binding region [chemical binding]; other site 1232724011263 ATP-binding site [chemical binding]; other site 1232724011264 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1232724011265 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232724011266 P-loop; other site 1232724011267 Magnesium ion binding site [ion binding]; other site 1232724011268 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232724011269 Magnesium ion binding site [ion binding]; other site 1232724011270 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724011271 catalytic core [active] 1232724011272 isochorismate synthase DhbC; Validated; Region: PRK06923 1232724011273 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1232724011274 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232724011275 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1232724011276 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1232724011277 Transcription factor WhiB; Region: Whib; pfam02467 1232724011278 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1232724011279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1232724011280 Histidine kinase; Region: HisKA_2; pfam07568 1232724011281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724011282 ATP binding site [chemical binding]; other site 1232724011283 Mg2+ binding site [ion binding]; other site 1232724011284 G-X-G motif; other site 1232724011285 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232724011286 carboxyltransferase (CT) interaction site; other site 1232724011287 biotinylation site [posttranslational modification]; other site 1232724011288 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1232724011289 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1232724011290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724011291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724011292 DNA binding residues [nucleotide binding] 1232724011293 short chain dehydrogenase; Provisional; Region: PRK08278 1232724011294 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1232724011295 NAD(P) binding site [chemical binding]; other site 1232724011296 homodimer interface [polypeptide binding]; other site 1232724011297 active site 1232724011298 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1232724011299 putative deacylase active site [active] 1232724011300 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724011301 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724011302 NAD(P) binding site [chemical binding]; other site 1232724011303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724011304 active site 1232724011305 metal binding site [ion binding]; metal-binding site 1232724011306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1232724011307 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232724011308 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1232724011309 short chain dehydrogenase; Provisional; Region: PRK07856 1232724011310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724011311 NAD(P) binding site [chemical binding]; other site 1232724011312 active site 1232724011313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724011314 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724011315 classical (c) SDRs; Region: SDR_c; cd05233 1232724011316 NAD(P) binding site [chemical binding]; other site 1232724011317 active site 1232724011318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724011319 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724011320 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724011321 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724011322 active site 1232724011323 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1232724011324 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1232724011325 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1232724011326 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1232724011327 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1232724011328 hinge; other site 1232724011329 active site 1232724011330 Predicted GTPases [General function prediction only]; Region: COG1162 1232724011331 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1232724011332 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1232724011333 GTP/Mg2+ binding site [chemical binding]; other site 1232724011334 G4 box; other site 1232724011335 G5 box; other site 1232724011336 G1 box; other site 1232724011337 Switch I region; other site 1232724011338 G2 box; other site 1232724011339 G3 box; other site 1232724011340 Switch II region; other site 1232724011341 Predicted transcriptional regulators [Transcription]; Region: COG1733 1232724011342 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1232724011343 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1232724011344 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724011345 dimer interface [polypeptide binding]; other site 1232724011346 active site 1232724011347 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1232724011348 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1232724011349 putative active site [active] 1232724011350 catalytic triad [active] 1232724011351 putative dimer interface [polypeptide binding]; other site 1232724011352 Domain of unknown function DUF302; Region: DUF302; pfam03625 1232724011353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724011354 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1232724011355 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1232724011356 putative di-iron ligands [ion binding]; other site 1232724011357 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1232724011358 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232724011359 FAD binding pocket [chemical binding]; other site 1232724011360 FAD binding motif [chemical binding]; other site 1232724011361 phosphate binding motif [ion binding]; other site 1232724011362 beta-alpha-beta structure motif; other site 1232724011363 NAD binding pocket [chemical binding]; other site 1232724011364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724011365 catalytic loop [active] 1232724011366 iron binding site [ion binding]; other site 1232724011367 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724011368 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724011369 NnrU protein; Region: NnrU; cl17713 1232724011370 Phospholipid methyltransferase; Region: PEMT; cl17370 1232724011371 HD domain; Region: HD_5; pfam13487 1232724011372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232724011373 Zn2+ binding site [ion binding]; other site 1232724011374 Mg2+ binding site [ion binding]; other site 1232724011375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724011376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724011377 DNA binding residues [nucleotide binding] 1232724011378 dimerization interface [polypeptide binding]; other site 1232724011379 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1232724011380 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1232724011381 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1232724011382 30S subunit binding site; other site 1232724011383 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1232724011384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232724011385 active site 1232724011386 lipoprotein LpqB; Provisional; Region: PRK13616 1232724011387 Sporulation and spore germination; Region: Germane; pfam10646 1232724011388 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1232724011389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1232724011390 dimerization interface [polypeptide binding]; other site 1232724011391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724011392 dimer interface [polypeptide binding]; other site 1232724011393 phosphorylation site [posttranslational modification] 1232724011394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724011395 ATP binding site [chemical binding]; other site 1232724011396 Mg2+ binding site [ion binding]; other site 1232724011397 G-X-G motif; other site 1232724011398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724011399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724011400 active site 1232724011401 phosphorylation site [posttranslational modification] 1232724011402 intermolecular recognition site; other site 1232724011403 dimerization interface [polypeptide binding]; other site 1232724011404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724011405 DNA binding site [nucleotide binding] 1232724011406 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1232724011407 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1232724011408 TMP-binding site; other site 1232724011409 ATP-binding site [chemical binding]; other site 1232724011410 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1232724011411 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1232724011412 homotetramer interface [polypeptide binding]; other site 1232724011413 ligand binding site [chemical binding]; other site 1232724011414 catalytic site [active] 1232724011415 NAD binding site [chemical binding]; other site 1232724011416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724011417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724011418 Rubredoxin [Energy production and conversion]; Region: COG1773 1232724011419 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1232724011420 iron binding site [ion binding]; other site 1232724011421 Rubredoxin [Energy production and conversion]; Region: COG1773 1232724011422 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1232724011423 iron binding site [ion binding]; other site 1232724011424 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1232724011425 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1232724011426 Di-iron ligands [ion binding]; other site 1232724011427 amino acid transporter; Region: 2A0306; TIGR00909 1232724011428 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1232724011429 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1232724011430 hypothetical protein; Provisional; Region: PRK07236 1232724011431 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1232724011432 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1232724011433 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1232724011434 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1232724011435 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1232724011436 active site 1232724011437 substrate binding site [chemical binding]; other site 1232724011438 metal binding site [ion binding]; metal-binding site 1232724011439 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1232724011440 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1232724011441 Transcription factor WhiB; Region: Whib; pfam02467 1232724011442 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1232724011443 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1232724011444 phosphate binding site [ion binding]; other site 1232724011445 dimer interface [polypeptide binding]; other site 1232724011446 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1232724011447 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1232724011448 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1232724011449 FMN binding site [chemical binding]; other site 1232724011450 dimer interface [polypeptide binding]; other site 1232724011451 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1232724011452 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1232724011453 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1232724011454 nudix motif; other site 1232724011455 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1232724011456 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1232724011457 active site 1232724011458 Substrate binding site; other site 1232724011459 Mg++ binding site; other site 1232724011460 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1232724011461 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1232724011462 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1232724011463 Probable Catalytic site; other site 1232724011464 metal-binding site 1232724011465 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1232724011466 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1232724011467 NADP binding site [chemical binding]; other site 1232724011468 active site 1232724011469 putative substrate binding site [chemical binding]; other site 1232724011470 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1232724011471 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232724011472 TIGR03089 family protein; Region: TIGR03089 1232724011473 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1232724011474 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232724011475 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724011476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1232724011477 active site 1232724011478 motif I; other site 1232724011479 motif II; other site 1232724011480 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1232724011481 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724011482 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724011483 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724011484 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724011485 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724011486 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724011487 active site 1232724011488 ATP binding site [chemical binding]; other site 1232724011489 substrate binding site [chemical binding]; other site 1232724011490 activation loop (A-loop); other site 1232724011491 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1232724011492 NHL repeat; Region: NHL; pfam01436 1232724011493 NHL repeat; Region: NHL; pfam01436 1232724011494 NHL repeat; Region: NHL; pfam01436 1232724011495 NHL repeat; Region: NHL; pfam01436 1232724011496 NHL repeat; Region: NHL; pfam01436 1232724011497 PBP superfamily domain; Region: PBP_like_2; cl17296 1232724011498 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 1232724011499 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1232724011500 Walker A/P-loop; other site 1232724011501 ATP binding site [chemical binding]; other site 1232724011502 Q-loop/lid; other site 1232724011503 ABC transporter signature motif; other site 1232724011504 Walker B; other site 1232724011505 D-loop; other site 1232724011506 H-loop/switch region; other site 1232724011507 PBP superfamily domain; Region: PBP_like_2; cl17296 1232724011508 PBP superfamily domain; Region: PBP_like_2; cl17296 1232724011509 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1232724011510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724011511 dimer interface [polypeptide binding]; other site 1232724011512 conserved gate region; other site 1232724011513 putative PBP binding loops; other site 1232724011514 ABC-ATPase subunit interface; other site 1232724011515 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1232724011516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232724011517 dimer interface [polypeptide binding]; other site 1232724011518 conserved gate region; other site 1232724011519 ABC-ATPase subunit interface; other site 1232724011520 Response regulator receiver domain; Region: Response_reg; pfam00072 1232724011521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724011522 active site 1232724011523 phosphorylation site [posttranslational modification] 1232724011524 intermolecular recognition site; other site 1232724011525 dimerization interface [polypeptide binding]; other site 1232724011526 CHASE3 domain; Region: CHASE3; pfam05227 1232724011527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724011528 dimer interface [polypeptide binding]; other site 1232724011529 phosphorylation site [posttranslational modification] 1232724011530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724011531 ATP binding site [chemical binding]; other site 1232724011532 Mg2+ binding site [ion binding]; other site 1232724011533 G-X-G motif; other site 1232724011534 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1232724011535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724011536 active site 1232724011537 phosphorylation site [posttranslational modification] 1232724011538 intermolecular recognition site; other site 1232724011539 dimerization interface [polypeptide binding]; other site 1232724011540 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1232724011541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724011542 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1232724011543 FAD binding site [chemical binding]; other site 1232724011544 homotetramer interface [polypeptide binding]; other site 1232724011545 substrate binding pocket [chemical binding]; other site 1232724011546 catalytic base [active] 1232724011547 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1232724011548 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1232724011549 ATP-grasp domain; Region: ATP-grasp; pfam02222 1232724011550 Predicted membrane protein [Function unknown]; Region: COG2246 1232724011551 GtrA-like protein; Region: GtrA; pfam04138 1232724011552 Bacterial PH domain; Region: DUF304; pfam03703 1232724011553 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1232724011554 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1232724011555 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1232724011556 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1232724011557 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1232724011558 acyl-CoA synthetase; Provisional; Region: PRK13388 1232724011559 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724011560 acyl-activating enzyme (AAE) consensus motif; other site 1232724011561 AMP binding site [chemical binding]; other site 1232724011562 active site 1232724011563 CoA binding site [chemical binding]; other site 1232724011564 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724011565 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1232724011566 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1232724011567 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232724011568 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1232724011569 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1232724011570 active site 1232724011571 dimer interface [polypeptide binding]; other site 1232724011572 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1232724011573 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1232724011574 active site residue [active] 1232724011575 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1232724011576 active site residue [active] 1232724011577 Fe-S metabolism associated domain; Region: SufE; cl00951 1232724011578 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1232724011579 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232724011580 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1232724011581 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232724011582 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232724011583 carboxyltransferase (CT) interaction site; other site 1232724011584 biotinylation site [posttranslational modification]; other site 1232724011585 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724011586 anti sigma factor interaction site; other site 1232724011587 regulatory phosphorylation site [posttranslational modification]; other site 1232724011588 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1232724011589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724011590 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1232724011591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724011592 DNA binding residues [nucleotide binding] 1232724011593 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1232724011594 L-lysine aminotransferase; Provisional; Region: PRK08297 1232724011595 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232724011596 inhibitor-cofactor binding pocket; inhibition site 1232724011597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724011598 catalytic residue [active] 1232724011599 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1232724011600 AsnC family; Region: AsnC_trans_reg; pfam01037 1232724011601 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1232724011602 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232724011603 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724011604 NAD(P) binding site [chemical binding]; other site 1232724011605 catalytic residues [active] 1232724011606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724011607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232724011608 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1232724011609 ATP binding site [chemical binding]; other site 1232724011610 putative Mg++ binding site [ion binding]; other site 1232724011611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232724011612 nucleotide binding region [chemical binding]; other site 1232724011613 ATP-binding site [chemical binding]; other site 1232724011614 DEAD/H associated; Region: DEAD_assoc; pfam08494 1232724011615 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1232724011616 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1232724011617 putative DNA binding site [nucleotide binding]; other site 1232724011618 catalytic residue [active] 1232724011619 putative H2TH interface [polypeptide binding]; other site 1232724011620 putative catalytic residues [active] 1232724011621 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232724011622 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232724011623 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1232724011624 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724011625 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1232724011626 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1232724011627 oligomer interface [polypeptide binding]; other site 1232724011628 metal binding site [ion binding]; metal-binding site 1232724011629 metal binding site [ion binding]; metal-binding site 1232724011630 putative Cl binding site [ion binding]; other site 1232724011631 aspartate ring; other site 1232724011632 basic sphincter; other site 1232724011633 hydrophobic gate; other site 1232724011634 periplasmic entrance; other site 1232724011635 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724011636 PPE family; Region: PPE; pfam00823 1232724011637 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724011638 PPE family; Region: PPE; pfam00823 1232724011639 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232724011640 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1232724011641 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1232724011642 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1232724011643 active site 1232724011644 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1232724011645 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1232724011646 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724011647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724011648 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724011649 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1232724011650 putative active site pocket [active] 1232724011651 dimerization interface [polypeptide binding]; other site 1232724011652 putative catalytic residue [active] 1232724011653 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724011654 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1232724011655 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1232724011656 metal binding site [ion binding]; metal-binding site 1232724011657 putative dimer interface [polypeptide binding]; other site 1232724011658 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1232724011659 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1232724011660 metal binding site [ion binding]; metal-binding site 1232724011661 Cutinase; Region: Cutinase; pfam01083 1232724011662 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1232724011663 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1232724011664 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1232724011665 active site 1232724011666 substrate binding site [chemical binding]; other site 1232724011667 metal binding site [ion binding]; metal-binding site 1232724011668 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1232724011669 hypothetical protein; Provisional; Region: PRK13685 1232724011670 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1232724011671 metal ion-dependent adhesion site (MIDAS); other site 1232724011672 hypothetical protein; Provisional; Region: PRK13685 1232724011673 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1232724011674 metal ion-dependent adhesion site (MIDAS); other site 1232724011675 Cupin domain; Region: Cupin_2; cl17218 1232724011676 Cupin domain; Region: Cupin_2; pfam07883 1232724011677 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232724011678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724011679 DNA-binding site [nucleotide binding]; DNA binding site 1232724011680 FCD domain; Region: FCD; pfam07729 1232724011681 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1232724011682 adenosine deaminase; Provisional; Region: PRK09358 1232724011683 active site 1232724011684 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1232724011685 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1232724011686 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1232724011687 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1232724011688 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1232724011689 active site 1232724011690 catalytic motif [active] 1232724011691 Zn binding site [ion binding]; other site 1232724011692 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1232724011693 putative Iron-sulfur protein interface [polypeptide binding]; other site 1232724011694 putative proximal heme binding site [chemical binding]; other site 1232724011695 putative SdhD-like interface [polypeptide binding]; other site 1232724011696 putative distal heme binding site [chemical binding]; other site 1232724011697 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1232724011698 putative Iron-sulfur protein interface [polypeptide binding]; other site 1232724011699 putative proximal heme binding site [chemical binding]; other site 1232724011700 putative SdhC-like subunit interface [polypeptide binding]; other site 1232724011701 putative distal heme binding site [chemical binding]; other site 1232724011702 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1232724011703 L-aspartate oxidase; Provisional; Region: PRK06175 1232724011704 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1232724011705 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1232724011706 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1232724011707 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724011708 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1232724011709 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1232724011710 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1232724011711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724011712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724011713 DNA binding residues [nucleotide binding] 1232724011714 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724011715 hypothetical protein; Provisional; Region: PRK06541 1232724011716 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232724011717 inhibitor-cofactor binding pocket; inhibition site 1232724011718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724011719 catalytic residue [active] 1232724011720 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1232724011721 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1232724011722 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1232724011723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724011724 putative substrate translocation pore; other site 1232724011725 Amidohydrolase; Region: Amidohydro_4; pfam13147 1232724011726 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724011727 active site 1232724011728 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1232724011729 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1232724011730 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1232724011731 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1232724011732 active site 1232724011733 HIGH motif; other site 1232724011734 dimer interface [polypeptide binding]; other site 1232724011735 KMSKS motif; other site 1232724011736 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724011737 isocitrate dehydrogenase; Validated; Region: PRK08299 1232724011738 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1232724011739 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1232724011740 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1232724011741 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1232724011742 homodimer interface [polypeptide binding]; other site 1232724011743 substrate-cofactor binding pocket; other site 1232724011744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724011745 catalytic residue [active] 1232724011746 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1232724011747 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1232724011748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724011749 S-adenosylmethionine binding site [chemical binding]; other site 1232724011750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724011751 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1232724011752 frameshift; Hypothetical protein 1232724011753 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724011754 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1232724011755 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1232724011756 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1232724011757 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1232724011758 homodimer interface [polypeptide binding]; other site 1232724011759 NADP binding site [chemical binding]; other site 1232724011760 substrate binding site [chemical binding]; other site 1232724011761 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1232724011762 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1232724011763 active site 1232724011764 FMN binding site [chemical binding]; other site 1232724011765 substrate binding site [chemical binding]; other site 1232724011766 putative catalytic residue [active] 1232724011767 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724011768 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724011769 phosphopeptide binding site; other site 1232724011770 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724011771 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724011772 phosphopeptide binding site; other site 1232724011773 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232724011774 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1232724011775 Walker A/P-loop; other site 1232724011776 ATP binding site [chemical binding]; other site 1232724011777 Q-loop/lid; other site 1232724011778 ABC transporter signature motif; other site 1232724011779 Walker B; other site 1232724011780 D-loop; other site 1232724011781 H-loop/switch region; other site 1232724011782 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1232724011783 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1232724011784 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724011785 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724011786 phosphopeptide binding site; other site 1232724011787 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1232724011788 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1232724011789 phosphopeptide binding site; other site 1232724011790 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232724011791 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1232724011792 Walker A/P-loop; other site 1232724011793 ATP binding site [chemical binding]; other site 1232724011794 Q-loop/lid; other site 1232724011795 ABC transporter signature motif; other site 1232724011796 Walker B; other site 1232724011797 D-loop; other site 1232724011798 H-loop/switch region; other site 1232724011799 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232724011800 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1232724011801 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1232724011802 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232724011803 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1232724011804 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1232724011805 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1232724011806 G1 box; other site 1232724011807 GTP/Mg2+ binding site [chemical binding]; other site 1232724011808 G2 box; other site 1232724011809 Switch I region; other site 1232724011810 G3 box; other site 1232724011811 Switch II region; other site 1232724011812 G4 box; other site 1232724011813 G5 box; other site 1232724011814 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1232724011815 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1232724011816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724011817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724011818 ATP binding site [chemical binding]; other site 1232724011819 Mg2+ binding site [ion binding]; other site 1232724011820 G-X-G motif; other site 1232724011821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724011822 S-adenosylmethionine binding site [chemical binding]; other site 1232724011823 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1232724011824 YCII-related domain; Region: YCII; cl00999 1232724011825 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1232724011826 FMN binding site [chemical binding]; other site 1232724011827 dimer interface [polypeptide binding]; other site 1232724011828 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1232724011829 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1232724011830 active site 1232724011831 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1232724011832 generic binding surface II; other site 1232724011833 generic binding surface I; other site 1232724011834 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1232724011835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724011836 active site 1232724011837 motif I; other site 1232724011838 motif II; other site 1232724011839 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724011840 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1232724011841 dimer interaction site [polypeptide binding]; other site 1232724011842 substrate-binding tunnel; other site 1232724011843 active site 1232724011844 catalytic site [active] 1232724011845 substrate binding site [chemical binding]; other site 1232724011846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724011847 catalytic core [active] 1232724011848 short chain dehydrogenase; Provisional; Region: PRK07201 1232724011849 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1232724011850 putative NAD(P) binding site [chemical binding]; other site 1232724011851 active site 1232724011852 putative substrate binding site [chemical binding]; other site 1232724011853 classical (c) SDRs; Region: SDR_c; cd05233 1232724011854 NAD(P) binding site [chemical binding]; other site 1232724011855 active site 1232724011856 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724011857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724011858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724011859 S-adenosylmethionine binding site [chemical binding]; other site 1232724011860 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1232724011861 active site 1232724011862 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1232724011863 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1232724011864 dimer interface [polypeptide binding]; other site 1232724011865 active site 1232724011866 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1232724011867 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1232724011868 putative active site [active] 1232724011869 putative substrate binding site [chemical binding]; other site 1232724011870 putative FMN binding site [chemical binding]; other site 1232724011871 putative catalytic residues [active] 1232724011872 DNA Polymerase Y-family; Region: PolY_like; cd03468 1232724011873 DNA binding site [nucleotide binding] 1232724011874 GMP synthase; Reviewed; Region: guaA; PRK00074 1232724011875 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1232724011876 AMP/PPi binding site [chemical binding]; other site 1232724011877 candidate oxyanion hole; other site 1232724011878 catalytic triad [active] 1232724011879 potential glutamine specificity residues [chemical binding]; other site 1232724011880 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1232724011881 ATP Binding subdomain [chemical binding]; other site 1232724011882 Ligand Binding sites [chemical binding]; other site 1232724011883 Dimerization subdomain; other site 1232724011884 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724011885 PPE family; Region: PPE; pfam00823 1232724011886 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724011887 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1232724011888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724011889 motif II; other site 1232724011890 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1232724011891 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1232724011892 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1232724011893 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1232724011894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724011895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724011896 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1232724011897 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1232724011898 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1232724011899 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1232724011900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232724011901 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1232724011902 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1232724011903 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232724011904 phosphate binding site [ion binding]; other site 1232724011905 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1232724011906 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232724011907 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1232724011908 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1232724011909 active site 1232724011910 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1232724011911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724011912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1232724011913 DNA binding residues [nucleotide binding] 1232724011914 Transcription factor WhiB; Region: Whib; pfam02467 1232724011915 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1232724011916 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1232724011917 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1232724011918 [2Fe-2S] cluster binding site [ion binding]; other site 1232724011919 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724011920 Fe binding site [ion binding]; other site 1232724011921 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1232724011922 E-class dimer interface [polypeptide binding]; other site 1232724011923 P-class dimer interface [polypeptide binding]; other site 1232724011924 active site 1232724011925 Cu2+ binding site [ion binding]; other site 1232724011926 Zn2+ binding site [ion binding]; other site 1232724011927 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1232724011928 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1232724011929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724011930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724011931 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1232724011932 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1232724011933 ring oligomerisation interface [polypeptide binding]; other site 1232724011934 ATP/Mg binding site [chemical binding]; other site 1232724011935 stacking interactions; other site 1232724011936 hinge regions; other site 1232724011937 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1232724011938 oligomerisation interface [polypeptide binding]; other site 1232724011939 mobile loop; other site 1232724011940 roof hairpin; other site 1232724011941 UGMP family protein; Validated; Region: PRK09604 1232724011942 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1232724011943 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1232724011944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724011945 Coenzyme A binding pocket [chemical binding]; other site 1232724011946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1232724011947 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1232724011948 Glycoprotease family; Region: Peptidase_M22; pfam00814 1232724011949 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1232724011950 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724011951 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724011952 alanine racemase; Reviewed; Region: alr; PRK00053 1232724011953 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1232724011954 active site 1232724011955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232724011956 dimer interface [polypeptide binding]; other site 1232724011957 substrate binding site [chemical binding]; other site 1232724011958 catalytic residues [active] 1232724011959 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1232724011960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724011961 catalytic residue [active] 1232724011962 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1232724011963 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1232724011964 putative substrate binding site [chemical binding]; other site 1232724011965 putative ATP binding site [chemical binding]; other site 1232724011966 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1232724011967 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1232724011968 glutaminase active site [active] 1232724011969 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1232724011970 dimer interface [polypeptide binding]; other site 1232724011971 active site 1232724011972 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1232724011973 dimer interface [polypeptide binding]; other site 1232724011974 active site 1232724011975 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724011976 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1232724011977 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724011978 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1232724011979 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1232724011980 active site 1232724011981 substrate binding site [chemical binding]; other site 1232724011982 metal binding site [ion binding]; metal-binding site 1232724011983 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1232724011984 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1232724011985 23S rRNA interface [nucleotide binding]; other site 1232724011986 L3 interface [polypeptide binding]; other site 1232724011987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1232724011988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1232724011989 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1232724011990 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724011991 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1232724011992 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724011993 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724011994 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1232724011995 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1232724011996 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1232724011997 active site 1232724011998 catalytic residues [active] 1232724011999 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1232724012000 Cutinase; Region: Cutinase; pfam01083 1232724012001 Cutinase; Region: Cutinase; pfam01083 1232724012002 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1232724012003 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1232724012004 active site 1232724012005 dimerization interface 3.5A [polypeptide binding]; other site 1232724012006 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1232724012007 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1232724012008 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1232724012009 alphaNTD homodimer interface [polypeptide binding]; other site 1232724012010 alphaNTD - beta interaction site [polypeptide binding]; other site 1232724012011 alphaNTD - beta' interaction site [polypeptide binding]; other site 1232724012012 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1232724012013 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1232724012014 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1232724012015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232724012016 RNA binding surface [nucleotide binding]; other site 1232724012017 30S ribosomal protein S11; Validated; Region: PRK05309 1232724012018 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1232724012019 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1232724012020 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1232724012021 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1232724012022 rRNA binding site [nucleotide binding]; other site 1232724012023 predicted 30S ribosome binding site; other site 1232724012024 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1232724012025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724012026 active site 1232724012027 phosphorylation site [posttranslational modification] 1232724012028 intermolecular recognition site; other site 1232724012029 dimerization interface [polypeptide binding]; other site 1232724012030 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1232724012031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724012032 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1232724012033 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1232724012034 ligand binding site [chemical binding]; other site 1232724012035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232724012036 flexible hinge region; other site 1232724012037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724012038 ATP binding site [chemical binding]; other site 1232724012039 Mg2+ binding site [ion binding]; other site 1232724012040 G-X-G motif; other site 1232724012041 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1232724012042 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1232724012043 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1232724012044 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1232724012045 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1232724012046 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1232724012047 NAD binding site [chemical binding]; other site 1232724012048 substrate binding site [chemical binding]; other site 1232724012049 homodimer interface [polypeptide binding]; other site 1232724012050 active site 1232724012051 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1232724012052 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724012053 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1232724012054 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724012055 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232724012056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1232724012057 active site 1232724012058 metal binding site [ion binding]; metal-binding site 1232724012059 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1232724012060 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1232724012061 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1232724012062 iron-sulfur cluster [ion binding]; other site 1232724012063 [2Fe-2S] cluster binding site [ion binding]; other site 1232724012064 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1232724012065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724012066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724012067 DNA binding residues [nucleotide binding] 1232724012068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724012069 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1232724012070 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1232724012071 tetrameric interface [polypeptide binding]; other site 1232724012072 NAD binding site [chemical binding]; other site 1232724012073 catalytic residues [active] 1232724012074 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724012075 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724012076 active site 1232724012077 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1232724012078 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1232724012079 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724012080 MarR family; Region: MarR; pfam01047 1232724012081 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1232724012082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724012083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724012084 homodimer interface [polypeptide binding]; other site 1232724012085 catalytic residue [active] 1232724012086 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1232724012087 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1232724012088 active site 1232724012089 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776 1232724012090 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1232724012091 PYR/PP interface [polypeptide binding]; other site 1232724012092 dimer interface [polypeptide binding]; other site 1232724012093 TPP binding site [chemical binding]; other site 1232724012094 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1232724012095 TPP-binding site [chemical binding]; other site 1232724012096 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1232724012097 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1232724012098 Walker A/P-loop; other site 1232724012099 ATP binding site [chemical binding]; other site 1232724012100 Q-loop/lid; other site 1232724012101 ABC transporter signature motif; other site 1232724012102 Walker B; other site 1232724012103 D-loop; other site 1232724012104 H-loop/switch region; other site 1232724012105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1232724012106 FtsX-like permease family; Region: FtsX; pfam02687 1232724012107 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1232724012108 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1232724012109 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724012110 Putative zinc-finger; Region: zf-HC2; pfam13490 1232724012111 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1232724012112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724012113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724012114 DNA binding residues [nucleotide binding] 1232724012115 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1232724012116 active site 1232724012117 adenylate kinase; Reviewed; Region: adk; PRK00279 1232724012118 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1232724012119 AMP-binding site [chemical binding]; other site 1232724012120 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1232724012121 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1232724012122 SecY translocase; Region: SecY; pfam00344 1232724012123 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724012124 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724012125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724012126 Coenzyme A binding pocket [chemical binding]; other site 1232724012127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724012128 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1232724012129 nucleotide binding site [chemical binding]; other site 1232724012130 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1232724012131 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1232724012132 NAD binding site [chemical binding]; other site 1232724012133 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1232724012134 intersubunit interface [polypeptide binding]; other site 1232724012135 active site 1232724012136 Zn2+ binding site [ion binding]; other site 1232724012137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724012138 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724012139 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724012140 NAD(P) binding site [chemical binding]; other site 1232724012141 classical (c) SDRs; Region: SDR_c; cd05233 1232724012142 NAD(P) binding site [chemical binding]; other site 1232724012143 active site 1232724012144 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724012145 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724012146 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724012147 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724012148 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724012149 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724012150 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1232724012151 tandem repeat interface [polypeptide binding]; other site 1232724012152 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1232724012153 oligomer interface [polypeptide binding]; other site 1232724012154 active site residues [active] 1232724012155 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1232724012156 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1232724012157 tandem repeat interface [polypeptide binding]; other site 1232724012158 oligomer interface [polypeptide binding]; other site 1232724012159 active site residues [active] 1232724012160 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724012161 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724012162 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1232724012163 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1232724012164 23S rRNA binding site [nucleotide binding]; other site 1232724012165 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1232724012166 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1232724012167 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1232724012168 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1232724012169 5S rRNA interface [nucleotide binding]; other site 1232724012170 L27 interface [polypeptide binding]; other site 1232724012171 23S rRNA interface [nucleotide binding]; other site 1232724012172 L5 interface [polypeptide binding]; other site 1232724012173 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1232724012174 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1232724012175 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1232724012176 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1232724012177 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1232724012178 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1232724012179 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1232724012180 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1232724012181 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1232724012182 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1232724012183 RNA binding site [nucleotide binding]; other site 1232724012184 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1232724012185 Cation efflux family; Region: Cation_efflux; cl00316 1232724012186 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1232724012187 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1232724012188 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724012189 PPE family; Region: PPE; pfam00823 1232724012190 PE family; Region: PE; pfam00934 1232724012191 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1232724012192 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232724012193 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232724012194 dimer interface [polypeptide binding]; other site 1232724012195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724012196 catalytic residue [active] 1232724012197 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1232724012198 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1232724012199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232724012200 catalytic residue [active] 1232724012201 Transposase; Region: HTH_Tnp_1; cl17663 1232724012202 putative transposase OrfB; Reviewed; Region: PHA02517 1232724012203 HTH-like domain; Region: HTH_21; pfam13276 1232724012204 Integrase core domain; Region: rve; pfam00665 1232724012205 Integrase core domain; Region: rve_3; cl15866 1232724012206 PE family; Region: PE; pfam00934 1232724012207 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724012208 PPE family; Region: PPE; pfam00823 1232724012209 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724012210 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1232724012211 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1232724012212 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1232724012213 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1232724012214 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1232724012215 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724012216 PPE family; Region: PPE; pfam00823 1232724012217 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724012218 PE family; Region: PE; pfam00934 1232724012219 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724012220 PPE family; Region: PPE; pfam00823 1232724012221 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724012222 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1232724012223 active site 1232724012224 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1232724012225 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1232724012226 putative active site [active] 1232724012227 putative NTP binding site [chemical binding]; other site 1232724012228 putative nucleic acid binding site [nucleotide binding]; other site 1232724012229 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1232724012230 Winged helix-turn helix; Region: HTH_29; pfam13551 1232724012231 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232724012232 Homeodomain-like domain; Region: HTH_32; pfam13565 1232724012233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1232724012234 Integrase core domain; Region: rve; pfam00665 1232724012235 Integrase core domain; Region: rve_3; pfam13683 1232724012236 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1232724012237 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232724012238 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724012239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724012240 active site 1232724012241 motif I; other site 1232724012242 motif II; other site 1232724012243 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1232724012244 MgtE intracellular N domain; Region: MgtE_N; smart00924 1232724012245 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1232724012246 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1232724012247 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1232724012248 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1232724012249 heme bH binding site [chemical binding]; other site 1232724012250 intrachain domain interface; other site 1232724012251 heme bL binding site [chemical binding]; other site 1232724012252 interchain domain interface [polypeptide binding]; other site 1232724012253 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1232724012254 Qo binding site; other site 1232724012255 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1232724012256 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1232724012257 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1232724012258 nudix motif; other site 1232724012259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724012260 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724012261 non-specific DNA binding site [nucleotide binding]; other site 1232724012262 salt bridge; other site 1232724012263 sequence-specific DNA binding site [nucleotide binding]; other site 1232724012264 PLD-like domain; Region: PLDc_2; pfam13091 1232724012265 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1232724012266 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724012267 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1232724012268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724012269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724012270 non-specific DNA binding site [nucleotide binding]; other site 1232724012271 salt bridge; other site 1232724012272 sequence-specific DNA binding site [nucleotide binding]; other site 1232724012273 Domain of unknown function (DUF955); Region: DUF955; cl01076 1232724012274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1232724012275 Coenzyme A binding pocket [chemical binding]; other site 1232724012276 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1232724012277 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1232724012278 catalytic residues [active] 1232724012279 Recombinase; Region: Recombinase; pfam07508 1232724012280 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724012281 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724012282 active site 1232724012283 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1232724012284 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1232724012285 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1232724012286 Sulfatase; Region: Sulfatase; pfam00884 1232724012287 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1232724012288 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1232724012289 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1232724012290 L23 interface [polypeptide binding]; other site 1232724012291 signal recognition particle (SRP54) interaction site; other site 1232724012292 trigger factor interaction site; other site 1232724012293 23S rRNA interface [nucleotide binding]; other site 1232724012294 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1232724012295 23S rRNA interface [nucleotide binding]; other site 1232724012296 5S rRNA interface [nucleotide binding]; other site 1232724012297 putative antibiotic binding site [chemical binding]; other site 1232724012298 L25 interface [polypeptide binding]; other site 1232724012299 L27 interface [polypeptide binding]; other site 1232724012300 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1232724012301 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1232724012302 G-X-X-G motif; other site 1232724012303 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1232724012304 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1232724012305 putative translocon binding site; other site 1232724012306 protein-rRNA interface [nucleotide binding]; other site 1232724012307 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1232724012308 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1232724012309 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1232724012310 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1232724012311 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1232724012312 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1232724012313 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1232724012314 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1232724012315 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724012316 Cytochrome P450; Region: p450; cl12078 1232724012317 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1232724012318 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1232724012319 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1232724012320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232724012321 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1232724012322 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1232724012323 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232724012324 phosphate binding site [ion binding]; other site 1232724012325 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1232724012326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232724012327 FeS/SAM binding site; other site 1232724012328 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1232724012329 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1232724012330 mycofactocin precursor; Region: mycofactocin; TIGR03969 1232724012331 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724012332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012333 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1232724012334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724012335 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724012336 active site 1232724012337 catalytic tetrad [active] 1232724012338 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1232724012339 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232724012340 active site 1232724012341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1232724012342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724012343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724012344 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724012345 classical (c) SDRs; Region: SDR_c; cd05233 1232724012346 NAD(P) binding site [chemical binding]; other site 1232724012347 active site 1232724012348 Short C-terminal domain; Region: SHOCT; pfam09851 1232724012349 PE family; Region: PE; pfam00934 1232724012350 elongation factor Tu; Reviewed; Region: PRK00049 1232724012351 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1232724012352 G1 box; other site 1232724012353 GEF interaction site [polypeptide binding]; other site 1232724012354 GTP/Mg2+ binding site [chemical binding]; other site 1232724012355 Switch I region; other site 1232724012356 G2 box; other site 1232724012357 G3 box; other site 1232724012358 Switch II region; other site 1232724012359 G4 box; other site 1232724012360 G5 box; other site 1232724012361 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1232724012362 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1232724012363 Antibiotic Binding Site [chemical binding]; other site 1232724012364 elongation factor G; Reviewed; Region: PRK00007 1232724012365 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1232724012366 G1 box; other site 1232724012367 putative GEF interaction site [polypeptide binding]; other site 1232724012368 GTP/Mg2+ binding site [chemical binding]; other site 1232724012369 Switch I region; other site 1232724012370 G2 box; other site 1232724012371 G3 box; other site 1232724012372 Switch II region; other site 1232724012373 G4 box; other site 1232724012374 G5 box; other site 1232724012375 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1232724012376 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1232724012377 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1232724012378 30S ribosomal protein S7; Validated; Region: PRK05302 1232724012379 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1232724012380 S17 interaction site [polypeptide binding]; other site 1232724012381 S8 interaction site; other site 1232724012382 16S rRNA interaction site [nucleotide binding]; other site 1232724012383 streptomycin interaction site [chemical binding]; other site 1232724012384 23S rRNA interaction site [nucleotide binding]; other site 1232724012385 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1232724012386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724012387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012388 WHG domain; Region: WHG; pfam13305 1232724012389 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1232724012390 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1232724012391 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724012392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724012393 substrate binding site [chemical binding]; other site 1232724012394 oxyanion hole (OAH) forming residues; other site 1232724012395 trimer interface [polypeptide binding]; other site 1232724012396 PaaX-like protein; Region: PaaX; pfam07848 1232724012397 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1232724012398 enoyl-CoA hydratase; Provisional; Region: PRK12478 1232724012399 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724012400 substrate binding site [chemical binding]; other site 1232724012401 oxyanion hole (OAH) forming residues; other site 1232724012402 trimer interface [polypeptide binding]; other site 1232724012403 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1232724012404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724012405 active site 1232724012406 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1232724012407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724012408 endonuclease IV; Provisional; Region: PRK01060 1232724012409 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1232724012410 AP (apurinic/apyrimidinic) site pocket; other site 1232724012411 DNA interaction; other site 1232724012412 Metal-binding active site; metal-binding site 1232724012413 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1232724012414 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1232724012415 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1232724012416 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1232724012417 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1232724012418 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1232724012419 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1232724012420 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1232724012421 G-loop; other site 1232724012422 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1232724012423 DNA binding site [nucleotide binding] 1232724012424 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1232724012425 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1232724012426 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1232724012427 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1232724012428 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1232724012429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1232724012430 RPB10 interaction site [polypeptide binding]; other site 1232724012431 RPB1 interaction site [polypeptide binding]; other site 1232724012432 RPB11 interaction site [polypeptide binding]; other site 1232724012433 RPB3 interaction site [polypeptide binding]; other site 1232724012434 RPB12 interaction site [polypeptide binding]; other site 1232724012435 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1232724012436 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1232724012437 Walker A/P-loop; other site 1232724012438 ATP binding site [chemical binding]; other site 1232724012439 Q-loop/lid; other site 1232724012440 ABC transporter signature motif; other site 1232724012441 Walker B; other site 1232724012442 D-loop; other site 1232724012443 H-loop/switch region; other site 1232724012444 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1232724012445 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1232724012446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724012447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012448 WHG domain; Region: WHG; pfam13305 1232724012449 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1232724012450 core dimer interface [polypeptide binding]; other site 1232724012451 peripheral dimer interface [polypeptide binding]; other site 1232724012452 L10 interface [polypeptide binding]; other site 1232724012453 L11 interface [polypeptide binding]; other site 1232724012454 putative EF-Tu interaction site [polypeptide binding]; other site 1232724012455 putative EF-G interaction site [polypeptide binding]; other site 1232724012456 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1232724012457 23S rRNA interface [nucleotide binding]; other site 1232724012458 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1232724012459 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1232724012460 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232724012461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724012462 nucleotide binding site [chemical binding]; other site 1232724012463 frameshift; alpha-mannosidase 1232724012464 DinB superfamily; Region: DinB_2; pfam12867 1232724012465 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1232724012466 DinB superfamily; Region: DinB_2; pfam12867 1232724012467 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1232724012468 ABC1 family; Region: ABC1; pfam03109 1232724012469 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1232724012470 active site 1232724012471 ATP binding site [chemical binding]; other site 1232724012472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724012473 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1232724012474 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724012475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012476 S-adenosylmethionine binding site [chemical binding]; other site 1232724012477 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724012478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012479 S-adenosylmethionine binding site [chemical binding]; other site 1232724012480 YCII-related domain; Region: YCII; cl00999 1232724012481 YCII-related domain; Region: YCII; cl00999 1232724012482 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1232724012483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724012484 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1232724012485 DNA binding residues [nucleotide binding] 1232724012486 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1232724012487 mRNA/rRNA interface [nucleotide binding]; other site 1232724012488 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1232724012489 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1232724012490 23S rRNA interface [nucleotide binding]; other site 1232724012491 L7/L12 interface [polypeptide binding]; other site 1232724012492 putative thiostrepton binding site; other site 1232724012493 L25 interface [polypeptide binding]; other site 1232724012494 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1232724012495 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1232724012496 putative homodimer interface [polypeptide binding]; other site 1232724012497 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1232724012498 heterodimer interface [polypeptide binding]; other site 1232724012499 homodimer interface [polypeptide binding]; other site 1232724012500 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1232724012501 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232724012502 active site 1232724012503 catalytic site [active] 1232724012504 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1232724012505 active site 1232724012506 catalytic site [active] 1232724012507 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232724012508 active site 1232724012509 catalytic site [active] 1232724012510 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1232724012511 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1232724012512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232724012513 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724012514 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724012515 substrate binding site [chemical binding]; other site 1232724012516 oxyanion hole (OAH) forming residues; other site 1232724012517 trimer interface [polypeptide binding]; other site 1232724012518 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1232724012519 [4Fe-4S] binding site [ion binding]; other site 1232724012520 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1232724012521 molybdopterin cofactor binding site; other site 1232724012522 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1232724012523 molybdopterin cofactor binding site; other site 1232724012524 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1232724012525 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1232724012526 active site 1232724012527 nucleophile elbow; other site 1232724012528 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1232724012529 cyanate hydratase; Validated; Region: PRK02866 1232724012530 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1232724012531 oligomer interface [polypeptide binding]; other site 1232724012532 active site 1232724012533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012534 S-adenosylmethionine binding site [chemical binding]; other site 1232724012535 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1232724012536 putative FMN binding site [chemical binding]; other site 1232724012537 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724012538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012539 S-adenosylmethionine binding site [chemical binding]; other site 1232724012540 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1232724012541 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1232724012542 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1232724012543 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1232724012544 Part of AAA domain; Region: AAA_19; pfam13245 1232724012545 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1232724012546 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1232724012547 AAA domain; Region: AAA_30; pfam13604 1232724012548 Family description; Region: UvrD_C_2; pfam13538 1232724012549 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1232724012550 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232724012551 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724012552 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724012553 active site 1232724012554 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724012555 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724012556 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1232724012557 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1232724012558 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1232724012559 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1232724012560 PAS fold; Region: PAS_3; pfam08447 1232724012561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1232724012562 putative active site [active] 1232724012563 heme pocket [chemical binding]; other site 1232724012564 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1232724012565 frameshift; Galactokinase 1232724012566 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1232724012567 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1232724012568 dimer interface [polypeptide binding]; other site 1232724012569 active site 1232724012570 Predicted membrane protein [Function unknown]; Region: COG1289 1232724012571 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1232724012572 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724012573 Cytochrome P450; Region: p450; cl12078 1232724012574 hypothetical protein; Provisional; Region: PRK07588 1232724012575 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724012576 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724012577 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724012578 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1232724012579 NYN domain; Region: NYN; pfam01936 1232724012580 putative metal binding site [ion binding]; other site 1232724012581 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1232724012582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724012583 Cytochrome P450; Region: p450; cl12078 1232724012584 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1232724012585 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1232724012586 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1232724012587 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724012588 molybdopterin cofactor binding site; other site 1232724012589 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 1232724012590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1232724012591 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1232724012592 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724012593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724012594 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1232724012595 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1232724012596 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1232724012597 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1232724012598 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1232724012599 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1232724012600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724012601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724012602 salt bridge; other site 1232724012603 non-specific DNA binding site [nucleotide binding]; other site 1232724012604 sequence-specific DNA binding site [nucleotide binding]; other site 1232724012605 heat shock protein HtpX; Provisional; Region: PRK03072 1232724012606 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232724012607 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232724012608 substrate binding pocket [chemical binding]; other site 1232724012609 chain length determination region; other site 1232724012610 substrate-Mg2+ binding site; other site 1232724012611 catalytic residues [active] 1232724012612 aspartate-rich region 1; other site 1232724012613 active site lid residues [active] 1232724012614 aspartate-rich region 2; other site 1232724012615 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1232724012616 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232724012617 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724012618 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1232724012619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012620 S-adenosylmethionine binding site [chemical binding]; other site 1232724012621 short chain dehydrogenase; Provisional; Region: PRK08263 1232724012622 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1232724012623 NADP binding site [chemical binding]; other site 1232724012624 active site 1232724012625 steroid binding site; other site 1232724012626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724012627 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1232724012628 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1232724012629 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1232724012630 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1232724012631 dimer interface [polypeptide binding]; other site 1232724012632 tetramer interface [polypeptide binding]; other site 1232724012633 PYR/PP interface [polypeptide binding]; other site 1232724012634 TPP binding site [chemical binding]; other site 1232724012635 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1232724012636 TPP-binding site; other site 1232724012637 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1232724012638 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724012639 TAP-like protein; Region: Abhydrolase_4; pfam08386 1232724012640 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1232724012641 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1232724012642 active site 1232724012643 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1232724012644 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1232724012645 active site 1232724012646 acyl-CoA synthetase; Validated; Region: PRK06188 1232724012647 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724012648 putative active site [active] 1232724012649 putative CoA binding site [chemical binding]; other site 1232724012650 putative AMP binding site [chemical binding]; other site 1232724012651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724012652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232724012654 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232724012655 active site 1232724012656 catalytic tetrad [active] 1232724012657 Domain of unknown function (DUF385); Region: DUF385; cl04387 1232724012658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724012659 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1232724012660 substrate binding site [chemical binding]; other site 1232724012661 oxyanion hole (OAH) forming residues; other site 1232724012662 trimer interface [polypeptide binding]; other site 1232724012663 short chain dehydrogenase; Provisional; Region: PRK05866 1232724012664 classical (c) SDRs; Region: SDR_c; cd05233 1232724012665 NAD(P) binding site [chemical binding]; other site 1232724012666 active site 1232724012667 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724012668 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1232724012669 active site 1232724012670 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1232724012671 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1232724012672 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1232724012673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724012674 acyl-activating enzyme (AAE) consensus motif; other site 1232724012675 AMP binding site [chemical binding]; other site 1232724012676 active site 1232724012677 CoA binding site [chemical binding]; other site 1232724012678 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1232724012679 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232724012680 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1232724012681 Ligand binding site; other site 1232724012682 Putative Catalytic site; other site 1232724012683 DXD motif; other site 1232724012684 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724012685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724012686 NAD(P) binding site [chemical binding]; other site 1232724012687 active site 1232724012688 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1232724012689 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1232724012690 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232724012691 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1232724012692 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1232724012693 dimer interface [polypeptide binding]; other site 1232724012694 active site 1232724012695 CoA binding pocket [chemical binding]; other site 1232724012696 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1232724012697 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232724012698 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232724012699 P-loop; other site 1232724012700 Magnesium ion binding site [ion binding]; other site 1232724012701 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1232724012702 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1232724012703 ResB-like family; Region: ResB; pfam05140 1232724012704 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1232724012705 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1232724012706 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1232724012707 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232724012708 catalytic residues [active] 1232724012709 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724012710 catalytic core [active] 1232724012711 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1232724012712 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232724012713 inhibitor-cofactor binding pocket; inhibition site 1232724012714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724012715 catalytic residue [active] 1232724012716 Domain of unknown function (DUF385); Region: DUF385; cl04387 1232724012717 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1232724012718 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1232724012719 metal binding site [ion binding]; metal-binding site 1232724012720 substrate binding pocket [chemical binding]; other site 1232724012721 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1232724012722 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1232724012723 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1232724012724 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1232724012725 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724012726 acyl-activating enzyme (AAE) consensus motif; other site 1232724012727 AMP binding site [chemical binding]; other site 1232724012728 active site 1232724012729 CoA binding site [chemical binding]; other site 1232724012730 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1232724012731 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1232724012732 putative NAD(P) binding site [chemical binding]; other site 1232724012733 active site 1232724012734 putative substrate binding site [chemical binding]; other site 1232724012735 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1232724012736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724012737 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232724012738 putative substrate translocation pore; other site 1232724012739 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1232724012740 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1232724012741 active site 1232724012742 dimer interface [polypeptide binding]; other site 1232724012743 non-prolyl cis peptide bond; other site 1232724012744 insertion regions; other site 1232724012745 Putative esterase; Region: Esterase; pfam00756 1232724012746 S-formylglutathione hydrolase; Region: PLN02442 1232724012747 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724012748 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1232724012749 active site 1232724012750 catalytic triad [active] 1232724012751 oxyanion hole [active] 1232724012752 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724012753 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724012754 anti sigma factor interaction site; other site 1232724012755 regulatory phosphorylation site [posttranslational modification]; other site 1232724012756 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1232724012757 dimer interface [polypeptide binding]; other site 1232724012758 active site 1232724012759 Schiff base residues; other site 1232724012760 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1232724012761 active site 1232724012762 homodimer interface [polypeptide binding]; other site 1232724012763 SAM binding site [chemical binding]; other site 1232724012764 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1232724012765 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1232724012766 active site 1232724012767 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1232724012768 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1232724012769 domain interfaces; other site 1232724012770 active site 1232724012771 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1232724012772 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1232724012773 tRNA; other site 1232724012774 putative tRNA binding site [nucleotide binding]; other site 1232724012775 putative NADP binding site [chemical binding]; other site 1232724012776 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1232724012777 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1232724012778 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1232724012779 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1232724012780 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1232724012781 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1232724012782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724012783 motif II; other site 1232724012784 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1232724012785 active site 1232724012786 catalytic site [active] 1232724012787 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724012788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232724012789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012790 S-adenosylmethionine binding site [chemical binding]; other site 1232724012791 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232724012792 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1232724012793 putative acyl-acceptor binding pocket; other site 1232724012794 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1232724012795 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1232724012796 putative NAD(P) binding site [chemical binding]; other site 1232724012797 active site 1232724012798 putative substrate binding site [chemical binding]; other site 1232724012799 DNA binding domain, excisionase family; Region: excise; TIGR01764 1232724012800 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1232724012801 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1232724012802 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1232724012803 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1232724012804 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724012805 active site 2 [active] 1232724012806 active site 1 [active] 1232724012807 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1232724012808 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1232724012809 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1232724012810 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1232724012811 DNA interaction; other site 1232724012812 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1232724012813 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1232724012814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232724012815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724012816 active site 1232724012817 phosphorylation site [posttranslational modification] 1232724012818 intermolecular recognition site; other site 1232724012819 dimerization interface [polypeptide binding]; other site 1232724012820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232724012821 DNA binding site [nucleotide binding] 1232724012822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232724012823 dimer interface [polypeptide binding]; other site 1232724012824 phosphorylation site [posttranslational modification] 1232724012825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232724012826 ATP binding site [chemical binding]; other site 1232724012827 Mg2+ binding site [ion binding]; other site 1232724012828 G-X-G motif; other site 1232724012829 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724012830 catalytic core [active] 1232724012831 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1232724012832 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1232724012833 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1232724012834 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1232724012835 putative ADP-binding pocket [chemical binding]; other site 1232724012836 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232724012837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724012838 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1232724012839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724012840 NAD(P) binding site [chemical binding]; other site 1232724012841 active site 1232724012842 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1232724012843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232724012844 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1232724012845 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232724012846 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1232724012847 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724012848 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1232724012849 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1232724012850 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1232724012851 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1232724012852 putative active site [active] 1232724012853 catalytic triad [active] 1232724012854 putative dimer interface [polypeptide binding]; other site 1232724012855 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1232724012856 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1232724012857 catalytic residue [active] 1232724012858 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1232724012859 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1232724012860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724012861 non-specific DNA binding site [nucleotide binding]; other site 1232724012862 salt bridge; other site 1232724012863 sequence-specific DNA binding site [nucleotide binding]; other site 1232724012864 Predicted membrane protein [Function unknown]; Region: COG2733 1232724012865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724012866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012867 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724012868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012869 S-adenosylmethionine binding site [chemical binding]; other site 1232724012870 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1232724012871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724012872 S-adenosylmethionine binding site [chemical binding]; other site 1232724012873 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1232724012874 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1232724012875 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1232724012876 isocitrate lyase; Provisional; Region: PRK15063 1232724012877 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232724012878 tetramer interface [polypeptide binding]; other site 1232724012879 active site 1232724012880 Mg2+/Mn2+ binding site [ion binding]; other site 1232724012881 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1232724012882 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724012883 active site 2 [active] 1232724012884 active site 1 [active] 1232724012885 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724012886 active site 2 [active] 1232724012887 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232724012888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232724012889 non-specific DNA binding site [nucleotide binding]; other site 1232724012890 salt bridge; other site 1232724012891 sequence-specific DNA binding site [nucleotide binding]; other site 1232724012892 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1232724012893 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1232724012894 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1232724012895 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1232724012896 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724012897 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1232724012898 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1232724012899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724012900 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232724012901 Protein of unknown function (DUF779); Region: DUF779; cl01432 1232724012902 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1232724012903 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724012904 NAD(P) binding site [chemical binding]; other site 1232724012905 catalytic residues [active] 1232724012906 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1232724012907 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724012908 enoyl-CoA hydratase; Provisional; Region: PRK12478 1232724012909 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724012910 substrate binding site [chemical binding]; other site 1232724012911 oxyanion hole (OAH) forming residues; other site 1232724012912 trimer interface [polypeptide binding]; other site 1232724012913 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1232724012914 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1232724012915 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1232724012916 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1232724012917 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1232724012918 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1232724012919 dimer interface [polypeptide binding]; other site 1232724012920 putative radical transfer pathway; other site 1232724012921 diiron center [ion binding]; other site 1232724012922 tyrosyl radical; other site 1232724012923 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1232724012924 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1232724012925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724012926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012927 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1232724012928 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1232724012929 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1232724012930 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232724012931 catalytic residues [active] 1232724012932 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1232724012933 DinB superfamily; Region: DinB_2; pfam12867 1232724012934 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1232724012935 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724012936 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1232724012937 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1232724012938 active site 1232724012939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724012940 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724012941 PPE family; Region: PPE; pfam00823 1232724012942 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1232724012943 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232724012944 classical (c) SDRs; Region: SDR_c; cd05233 1232724012945 NAD(P) binding site [chemical binding]; other site 1232724012946 active site 1232724012947 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1232724012948 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1232724012949 ring oligomerisation interface [polypeptide binding]; other site 1232724012950 ATP/Mg binding site [chemical binding]; other site 1232724012951 stacking interactions; other site 1232724012952 hinge regions; other site 1232724012953 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1232724012954 active site 1232724012955 Cupin domain; Region: Cupin_2; pfam07883 1232724012956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012957 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1232724012958 short chain dehydrogenase; Provisional; Region: PRK06197 1232724012959 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1232724012960 putative NAD(P) binding site [chemical binding]; other site 1232724012961 active site 1232724012962 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1232724012963 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1232724012964 dimer interface [polypeptide binding]; other site 1232724012965 putative functional site; other site 1232724012966 putative MPT binding site; other site 1232724012967 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1232724012968 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1232724012969 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1232724012970 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1232724012971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724012972 Walker A motif; other site 1232724012973 ATP binding site [chemical binding]; other site 1232724012974 Walker B motif; other site 1232724012975 arginine finger; other site 1232724012976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724012977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724012978 oxidoreductase; Provisional; Region: PRK06196 1232724012979 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1232724012980 putative NAD(P) binding site [chemical binding]; other site 1232724012981 active site 1232724012982 enoyl-CoA hydratase; Provisional; Region: PRK08260 1232724012983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724012984 substrate binding site [chemical binding]; other site 1232724012985 oxyanion hole (OAH) forming residues; other site 1232724012986 trimer interface [polypeptide binding]; other site 1232724012987 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724012988 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724012989 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1232724012990 carboxylate-amine ligase; Provisional; Region: PRK13517 1232724012991 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1232724012992 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1232724012993 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1232724012994 E-class dimer interface [polypeptide binding]; other site 1232724012995 P-class dimer interface [polypeptide binding]; other site 1232724012996 active site 1232724012997 Cu2+ binding site [ion binding]; other site 1232724012998 Zn2+ binding site [ion binding]; other site 1232724012999 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232724013000 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1232724013001 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1232724013002 active site 1232724013003 catalytic residues [active] 1232724013004 metal binding site [ion binding]; metal-binding site 1232724013005 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1232724013006 putative catalytic site [active] 1232724013007 putative phosphate binding site [ion binding]; other site 1232724013008 active site 1232724013009 metal binding site A [ion binding]; metal-binding site 1232724013010 DNA binding site [nucleotide binding] 1232724013011 putative AP binding site [nucleotide binding]; other site 1232724013012 putative metal binding site B [ion binding]; other site 1232724013013 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1232724013014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724013015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724013016 motif II; other site 1232724013017 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1232724013018 PAS fold; Region: PAS_3; pfam08447 1232724013019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1232724013020 putative active site [active] 1232724013021 heme pocket [chemical binding]; other site 1232724013022 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1232724013023 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1232724013024 ThiC-associated domain; Region: ThiC-associated; pfam13667 1232724013025 ThiC family; Region: ThiC; pfam01964 1232724013026 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1232724013027 dimer interface [polypeptide binding]; other site 1232724013028 substrate binding site [chemical binding]; other site 1232724013029 ATP binding site [chemical binding]; other site 1232724013030 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1232724013031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1232724013032 MarR family; Region: MarR; pfam01047 1232724013033 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1232724013034 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724013035 Predicted metalloprotease [General function prediction only]; Region: COG2321 1232724013036 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1232724013037 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1232724013038 Beta-lactamase; Region: Beta-lactamase; pfam00144 1232724013039 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724013040 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724013041 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1232724013042 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1232724013043 active site 1232724013044 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724013045 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724013046 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232724013047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1232724013048 active site 1232724013049 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1232724013050 Peptidase family M23; Region: Peptidase_M23; pfam01551 1232724013051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013052 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1232724013053 NAD(P) binding site [chemical binding]; other site 1232724013054 active site 1232724013055 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1232724013056 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1232724013057 PA/protease or protease-like domain interface [polypeptide binding]; other site 1232724013058 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1232724013059 Peptidase family M28; Region: Peptidase_M28; pfam04389 1232724013060 active site 1232724013061 metal binding site [ion binding]; metal-binding site 1232724013062 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1232724013063 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1232724013064 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1232724013065 PA/protease or protease-like domain interface [polypeptide binding]; other site 1232724013066 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1232724013067 active site 1232724013068 metal binding site [ion binding]; metal-binding site 1232724013069 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1232724013070 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1232724013071 active site 1232724013072 oxyanion hole [active] 1232724013073 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1232724013074 catalytic triad [active] 1232724013075 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1232724013076 ThiS interaction site; other site 1232724013077 putative active site [active] 1232724013078 tetramer interface [polypeptide binding]; other site 1232724013079 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1232724013080 thiS-thiF/thiG interaction site; other site 1232724013081 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1232724013082 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1232724013083 thiamine phosphate binding site [chemical binding]; other site 1232724013084 active site 1232724013085 pyrophosphate binding site [ion binding]; other site 1232724013086 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1232724013087 nudix motif; other site 1232724013088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232724013089 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1232724013090 substrate binding pocket [chemical binding]; other site 1232724013091 membrane-bound complex binding site; other site 1232724013092 hinge residues; other site 1232724013093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1232724013094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1232724013095 active site 1232724013096 ATP binding site [chemical binding]; other site 1232724013097 substrate binding site [chemical binding]; other site 1232724013098 activation loop (A-loop); other site 1232724013099 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1232724013100 putative active site [active] 1232724013101 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1232724013102 propionate/acetate kinase; Provisional; Region: PRK12379 1232724013103 phosphate acetyltransferase; Reviewed; Region: PRK05632 1232724013104 DRTGG domain; Region: DRTGG; pfam07085 1232724013105 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1232724013106 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1232724013107 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1232724013108 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724013109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1232724013110 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724013111 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1232724013112 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1232724013113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013114 NAD(P) binding site [chemical binding]; other site 1232724013115 active site 1232724013116 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1232724013117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013118 FAD binding site [chemical binding]; other site 1232724013119 substrate binding pocket [chemical binding]; other site 1232724013120 catalytic base [active] 1232724013121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724013123 active site 1232724013124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013126 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232724013127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724013128 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1232724013129 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1232724013130 homodimer interface [polypeptide binding]; other site 1232724013131 substrate-cofactor binding pocket; other site 1232724013132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724013133 catalytic residue [active] 1232724013134 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1232724013135 active site residue [active] 1232724013136 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1232724013137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013138 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232724013139 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724013140 CoenzymeA binding site [chemical binding]; other site 1232724013141 subunit interaction site [polypeptide binding]; other site 1232724013142 PHB binding site; other site 1232724013143 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1232724013144 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1232724013145 GDP-binding site [chemical binding]; other site 1232724013146 ACT binding site; other site 1232724013147 IMP binding site; other site 1232724013148 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1232724013149 catalytic core [active] 1232724013150 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1232724013151 Peptidase family M50; Region: Peptidase_M50; pfam02163 1232724013152 active site 1232724013153 putative substrate binding region [chemical binding]; other site 1232724013154 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1232724013155 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1232724013156 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1232724013157 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1232724013158 active site 1232724013159 intersubunit interface [polypeptide binding]; other site 1232724013160 zinc binding site [ion binding]; other site 1232724013161 Na+ binding site [ion binding]; other site 1232724013162 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232724013163 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1232724013164 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1232724013165 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1232724013166 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1232724013167 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1232724013168 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232724013169 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232724013170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232724013171 active site 1232724013172 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232724013173 classical (c) SDRs; Region: SDR_c; cd05233 1232724013174 NAD(P) binding site [chemical binding]; other site 1232724013175 active site 1232724013176 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724013178 active site 1232724013179 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1232724013180 Clp amino terminal domain; Region: Clp_N; pfam02861 1232724013181 Clp amino terminal domain; Region: Clp_N; pfam02861 1232724013182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724013183 Walker A motif; other site 1232724013184 ATP binding site [chemical binding]; other site 1232724013185 Walker B motif; other site 1232724013186 arginine finger; other site 1232724013187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724013188 Walker A motif; other site 1232724013189 ATP binding site [chemical binding]; other site 1232724013190 Walker B motif; other site 1232724013191 arginine finger; other site 1232724013192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1232724013193 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1232724013194 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1232724013195 heme-binding site [chemical binding]; other site 1232724013196 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1232724013197 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1232724013198 FAD binding pocket [chemical binding]; other site 1232724013199 FAD binding motif [chemical binding]; other site 1232724013200 phosphate binding motif [ion binding]; other site 1232724013201 beta-alpha-beta structure motif; other site 1232724013202 NAD binding pocket [chemical binding]; other site 1232724013203 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1232724013204 active site 1232724013205 catalytic residues [active] 1232724013206 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1232724013207 DNA binding residues [nucleotide binding] 1232724013208 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1232724013209 putative dimer interface [polypeptide binding]; other site 1232724013210 chaperone protein DnaJ; Provisional; Region: PRK14279 1232724013211 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1232724013212 HSP70 interaction site [polypeptide binding]; other site 1232724013213 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1232724013214 Zn binding sites [ion binding]; other site 1232724013215 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1232724013216 dimer interface [polypeptide binding]; other site 1232724013217 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1232724013218 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1232724013219 dimer interface [polypeptide binding]; other site 1232724013220 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1232724013221 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1232724013222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724013223 nucleotide binding site [chemical binding]; other site 1232724013224 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1232724013225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724013226 putative substrate translocation pore; other site 1232724013227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724013228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724013229 nucleotide binding site [chemical binding]; other site 1232724013230 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1232724013231 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1232724013232 4Fe-4S binding domain; Region: Fer4; pfam00037 1232724013233 Cysteine-rich domain; Region: CCG; pfam02754 1232724013234 Cysteine-rich domain; Region: CCG; pfam02754 1232724013235 aminotransferase AlaT; Validated; Region: PRK09265 1232724013236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232724013237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232724013238 homodimer interface [polypeptide binding]; other site 1232724013239 catalytic residue [active] 1232724013240 YibE/F-like protein; Region: YibE_F; pfam07907 1232724013241 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1232724013242 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1232724013243 substrate binding site; other site 1232724013244 tetramer interface; other site 1232724013245 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724013246 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1232724013247 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1232724013248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724013249 S-adenosylmethionine binding site [chemical binding]; other site 1232724013250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724013251 putative substrate translocation pore; other site 1232724013252 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1232724013253 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1232724013254 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1232724013255 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1232724013256 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1232724013257 trimer interface [polypeptide binding]; other site 1232724013258 active site 1232724013259 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1232724013260 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724013261 Emopamil binding protein; Region: EBP; pfam05241 1232724013262 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1232724013263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232724013264 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232724013265 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724013266 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724013267 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1232724013268 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1232724013269 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1232724013270 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1232724013271 active site 1232724013272 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1232724013273 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1232724013274 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1232724013275 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1232724013276 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1232724013277 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1232724013278 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1232724013279 active site 1232724013280 catalytic residues [active] 1232724013281 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1232724013282 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1232724013283 NAD(P) binding site [chemical binding]; other site 1232724013284 substrate binding site [chemical binding]; other site 1232724013285 dimer interface [polypeptide binding]; other site 1232724013286 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1232724013287 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232724013288 nucleotide binding site [chemical binding]; other site 1232724013289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013291 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724013292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1232724013293 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1232724013294 active site 1232724013295 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1232724013296 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1232724013297 putative FMN binding site [chemical binding]; other site 1232724013298 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1232724013299 Sulfatase; Region: Sulfatase; pfam00884 1232724013300 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1232724013301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724013302 S-adenosylmethionine binding site [chemical binding]; other site 1232724013303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724013304 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724013305 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1232724013306 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1232724013307 Subtilase family; Region: Peptidase_S8; pfam00082 1232724013308 catalytic residues [active] 1232724013309 catalytic residues [active] 1232724013310 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1232724013311 EspG family; Region: ESX-1_EspG; pfam14011 1232724013312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1232724013313 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724013314 PPE family; Region: PPE; pfam00823 1232724013315 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1232724013316 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724013317 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1232724013318 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724013319 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724013320 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1232724013321 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1232724013322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232724013323 Walker A motif; other site 1232724013324 ATP binding site [chemical binding]; other site 1232724013325 Walker B motif; other site 1232724013326 arginine finger; other site 1232724013327 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724013328 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724013329 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1232724013330 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1232724013331 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1232724013332 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1232724013333 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1232724013334 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1232724013335 30S ribosomal protein S18; Provisional; Region: PRK13401 1232724013336 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724013337 PPE family; Region: PPE; pfam00823 1232724013338 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1232724013339 Condensation domain; Region: Condensation; pfam00668 1232724013340 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1232724013341 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232724013342 Zn binding site [ion binding]; other site 1232724013343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013345 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724013346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724013348 active site 1232724013349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013350 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1232724013351 FAD binding site [chemical binding]; other site 1232724013352 substrate binding site [chemical binding]; other site 1232724013353 catalytic base [active] 1232724013354 acyl-CoA synthetase; Validated; Region: PRK07788 1232724013355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013356 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013357 active site 1232724013358 CoA binding site [chemical binding]; other site 1232724013359 AMP binding site [chemical binding]; other site 1232724013360 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1232724013361 nucleotide binding site [chemical binding]; other site 1232724013362 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1232724013363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724013364 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232724013365 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1232724013366 intersubunit interface [polypeptide binding]; other site 1232724013367 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1232724013368 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1232724013369 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1232724013370 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1232724013371 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1232724013372 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1232724013373 active site 1232724013374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1232724013375 DNA binding site [nucleotide binding] 1232724013376 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1232724013377 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1232724013378 putative active site [active] 1232724013379 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1232724013380 active site 1232724013381 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1232724013382 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1232724013383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724013384 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1232724013385 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1232724013386 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1232724013387 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1232724013388 putative dimer interface [polypeptide binding]; other site 1232724013389 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1232724013390 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1232724013391 tetramer interface [polypeptide binding]; other site 1232724013392 active site 1232724013393 Mg2+/Mn2+ binding site [ion binding]; other site 1232724013394 frameshift; succinate dehydrogenase flavoprotein subunit 1232724013395 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1232724013396 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724013397 catalytic loop [active] 1232724013398 iron binding site [ion binding]; other site 1232724013399 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1232724013400 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1232724013401 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1232724013402 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1232724013403 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1232724013404 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1232724013405 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1232724013406 FAD binding site [chemical binding]; other site 1232724013407 substrate binding site [chemical binding]; other site 1232724013408 catalytic residues [active] 1232724013409 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1232724013410 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1232724013411 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232724013412 dimer interface [polypeptide binding]; other site 1232724013413 active site 1232724013414 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1232724013415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013416 NAD(P) binding site [chemical binding]; other site 1232724013417 active site 1232724013418 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724013419 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724013420 active site 2 [active] 1232724013421 active site 1 [active] 1232724013422 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1232724013423 Cl- selectivity filter; other site 1232724013424 Cl- binding residues [ion binding]; other site 1232724013425 pore gating glutamate residue; other site 1232724013426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013428 frameshift; Putative transposase y4qE 1232724013429 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1232724013430 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1232724013431 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1232724013432 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1232724013433 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1232724013434 Lipase maturation factor; Region: LMF1; pfam06762 1232724013435 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1232724013436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232724013437 substrate binding pocket [chemical binding]; other site 1232724013438 membrane-bound complex binding site; other site 1232724013439 hinge residues; other site 1232724013440 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724013441 PPE family; Region: PPE; pfam00823 1232724013442 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724013443 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1232724013444 PPE family; Region: PPE; pfam00823 1232724013445 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1232724013446 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1232724013447 formate dehydrogenase; Provisional; Region: PRK07574 1232724013448 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1232724013449 dimerization interface [polypeptide binding]; other site 1232724013450 ligand binding site [chemical binding]; other site 1232724013451 NAD binding site [chemical binding]; other site 1232724013452 catalytic site [active] 1232724013453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232724013454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724013455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1232724013456 dimerization interface [polypeptide binding]; other site 1232724013457 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1232724013458 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1232724013459 Helix-turn-helix domain; Region: HTH_20; pfam12840 1232724013460 putative DNA binding site [nucleotide binding]; other site 1232724013461 Predicted transcriptional regulator [Transcription]; Region: COG2345 1232724013462 putative Zn2+ binding site [ion binding]; other site 1232724013463 Suppression of tumorigenicity 7; Region: ST7; cd11557 1232724013464 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1232724013465 acetolactate synthase; Reviewed; Region: PRK08322 1232724013466 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232724013467 PYR/PP interface [polypeptide binding]; other site 1232724013468 dimer interface [polypeptide binding]; other site 1232724013469 TPP binding site [chemical binding]; other site 1232724013470 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724013471 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1232724013472 TPP-binding site [chemical binding]; other site 1232724013473 dimer interface [polypeptide binding]; other site 1232724013474 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1232724013475 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1232724013476 NAD(P) binding site [chemical binding]; other site 1232724013477 catalytic residues [active] 1232724013478 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1232724013479 active site 1232724013480 diiron metal binding site [ion binding]; other site 1232724013481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013484 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232724013485 active site 1232724013486 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1232724013487 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1232724013488 active site 1232724013489 substrate binding pocket [chemical binding]; other site 1232724013490 homodimer interaction site [polypeptide binding]; other site 1232724013491 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013492 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1232724013493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013494 AMP binding site [chemical binding]; other site 1232724013495 active site 1232724013496 acyl-activating enzyme (AAE) consensus motif; other site 1232724013497 acyl-activating enzyme (AAE) consensus motif; other site 1232724013498 CoA binding site [chemical binding]; other site 1232724013499 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1232724013500 O-methyltransferase; Region: Methyltransf_2; pfam00891 1232724013501 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724013502 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1232724013503 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232724013504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232724013505 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232724013506 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232724013507 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1232724013508 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1232724013509 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1232724013510 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724013511 NAD binding site [chemical binding]; other site 1232724013512 catalytic residues [active] 1232724013513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013515 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232724013516 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013517 acyl-activating enzyme (AAE) consensus motif; other site 1232724013518 AMP binding site [chemical binding]; other site 1232724013519 active site 1232724013520 CoA binding site [chemical binding]; other site 1232724013521 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1232724013522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013524 enoyl-CoA hydratase; Provisional; Region: PRK08252 1232724013525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724013526 substrate binding site [chemical binding]; other site 1232724013527 oxyanion hole (OAH) forming residues; other site 1232724013528 trimer interface [polypeptide binding]; other site 1232724013529 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1232724013530 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1232724013531 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1232724013532 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724013533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724013534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232724013535 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1232724013536 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1232724013537 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724013538 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724013539 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724013540 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724013541 active site 1232724013542 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724013543 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724013544 active site 2 [active] 1232724013545 active site 1 [active] 1232724013546 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232724013547 active site 2 [active] 1232724013548 active site 1 [active] 1232724013549 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013550 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724013551 active site 1232724013552 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1232724013553 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1232724013554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1232724013555 substrate binding site [chemical binding]; other site 1232724013556 oxyanion hole (OAH) forming residues; other site 1232724013557 trimer interface [polypeptide binding]; other site 1232724013558 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1232724013559 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013560 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724013561 acyl-activating enzyme (AAE) consensus motif; other site 1232724013562 acyl-activating enzyme (AAE) consensus motif; other site 1232724013563 putative AMP binding site [chemical binding]; other site 1232724013564 putative active site [active] 1232724013565 putative CoA binding site [chemical binding]; other site 1232724013566 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1232724013567 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1232724013568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1232724013569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1232724013570 metal binding site [ion binding]; metal-binding site 1232724013571 active site 1232724013572 I-site; other site 1232724013573 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1232724013574 active site 1232724013575 substrate-binding site [chemical binding]; other site 1232724013576 metal-binding site [ion binding] 1232724013577 GTP binding site [chemical binding]; other site 1232724013578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724013579 S-adenosylmethionine binding site [chemical binding]; other site 1232724013580 LabA_like proteins; Region: LabA_like; cd06167 1232724013581 putative metal binding site [ion binding]; other site 1232724013582 MMPL family; Region: MMPL; pfam03176 1232724013583 MMPL family; Region: MMPL; pfam03176 1232724013584 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1232724013585 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1232724013586 Predicted integral membrane protein [Function unknown]; Region: COG0392 1232724013587 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1232724013588 Protein export membrane protein; Region: SecD_SecF; cl14618 1232724013589 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1232724013590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1232724013591 non-specific DNA binding site [nucleotide binding]; other site 1232724013592 salt bridge; other site 1232724013593 sequence-specific DNA binding site [nucleotide binding]; other site 1232724013594 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1232724013595 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1232724013596 active site 1232724013597 Zn binding site [ion binding]; other site 1232724013598 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1232724013599 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724013600 molybdopterin cofactor binding site; other site 1232724013601 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1232724013602 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1232724013603 putative molybdopterin cofactor binding site; other site 1232724013604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232724013607 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1232724013608 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232724013609 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1232724013610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232724013611 putative substrate translocation pore; other site 1232724013612 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1232724013613 putative homodimer interface [polypeptide binding]; other site 1232724013614 putative homotetramer interface [polypeptide binding]; other site 1232724013615 putative allosteric switch controlling residues; other site 1232724013616 putative metal binding site [ion binding]; other site 1232724013617 putative homodimer-homodimer interface [polypeptide binding]; other site 1232724013618 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1232724013619 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1232724013620 SPW repeat; Region: SPW; pfam03779 1232724013621 SPW repeat; Region: SPW; pfam03779 1232724013622 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1232724013623 FMN binding site [chemical binding]; other site 1232724013624 substrate binding site [chemical binding]; other site 1232724013625 putative catalytic residue [active] 1232724013626 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1232724013627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724013628 S-adenosylmethionine binding site [chemical binding]; other site 1232724013629 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1232724013630 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1232724013631 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1232724013632 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1232724013633 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1232724013634 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1232724013635 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1232724013636 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724013637 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1232724013638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724013639 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1232724013640 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724013641 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724013642 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232724013643 Pirin-related protein [General function prediction only]; Region: COG1741 1232724013644 Pirin; Region: Pirin; pfam02678 1232724013645 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1232724013646 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1232724013647 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1232724013648 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1232724013649 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1232724013650 RDD family; Region: RDD; pfam06271 1232724013651 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724013652 mce related protein; Region: MCE; pfam02470 1232724013653 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724013654 mce related protein; Region: MCE; pfam02470 1232724013655 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724013656 mce related protein; Region: MCE; pfam02470 1232724013657 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724013658 mce related protein; Region: MCE; pfam02470 1232724013659 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724013660 mce related protein; Region: MCE; pfam02470 1232724013661 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1232724013662 mce related protein; Region: MCE; pfam02470 1232724013663 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1232724013664 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724013665 Permease; Region: Permease; pfam02405 1232724013666 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232724013667 Permease; Region: Permease; pfam02405 1232724013668 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1232724013669 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013670 acyl-activating enzyme (AAE) consensus motif; other site 1232724013671 AMP binding site [chemical binding]; other site 1232724013672 active site 1232724013673 CoA binding site [chemical binding]; other site 1232724013674 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1232724013675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724013676 DNA-binding site [nucleotide binding]; DNA binding site 1232724013677 FCD domain; Region: FCD; pfam07729 1232724013678 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1232724013679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1232724013680 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1232724013681 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1232724013682 putative hydrophobic ligand binding site [chemical binding]; other site 1232724013683 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1232724013684 active site 1232724013685 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1232724013686 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724013687 NAD(P) binding site [chemical binding]; other site 1232724013688 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232724013689 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232724013690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724013691 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724013692 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1232724013693 classical (c) SDRs; Region: SDR_c; cd05233 1232724013694 NAD(P) binding site [chemical binding]; other site 1232724013695 active site 1232724013696 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1232724013697 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1232724013698 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232724013699 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724013700 NAD(P) binding site [chemical binding]; other site 1232724013701 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724013702 Cytochrome P450; Region: p450; cl12078 1232724013703 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724013704 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724013705 short chain dehydrogenase; Validated; Region: PRK08264 1232724013706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013707 NAD(P) binding site [chemical binding]; other site 1232724013708 active site 1232724013709 Domain of unknown function (DUF427); Region: DUF427; cl00998 1232724013710 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1232724013711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724013713 active site 1232724013714 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1232724013715 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1232724013716 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1232724013717 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1232724013718 active site 1232724013719 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1232724013720 catalytic triad [active] 1232724013721 dimer interface [polypeptide binding]; other site 1232724013722 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724013723 hydrophobic ligand binding site; other site 1232724013724 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1232724013725 Strictosidine synthase; Region: Str_synth; pfam03088 1232724013726 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1232724013727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013729 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232724013730 FAD binding domain; Region: FAD_binding_4; pfam01565 1232724013731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013732 NAD(P) binding site [chemical binding]; other site 1232724013733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724013734 active site 1232724013735 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1232724013736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1232724013737 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232724013738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013740 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1232724013741 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1232724013742 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1232724013743 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1232724013744 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1232724013745 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1232724013746 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1232724013747 ligand binding site [chemical binding]; other site 1232724013748 homodimer interface [polypeptide binding]; other site 1232724013749 NAD(P) binding site [chemical binding]; other site 1232724013750 trimer interface B [polypeptide binding]; other site 1232724013751 trimer interface A [polypeptide binding]; other site 1232724013752 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1232724013753 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724013754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724013755 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1232724013756 FAD binding site [chemical binding]; other site 1232724013757 substrate binding site [chemical binding]; other site 1232724013758 catalytic base [active] 1232724013759 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1232724013760 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1232724013761 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1232724013762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232724013763 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1232724013764 NAD binding site [chemical binding]; other site 1232724013765 homodimer interface [polypeptide binding]; other site 1232724013766 active site 1232724013767 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1232724013768 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1232724013769 NAD(P) binding site [chemical binding]; other site 1232724013770 catalytic residues [active] 1232724013771 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1232724013772 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1232724013773 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724013774 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724013775 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724013776 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1232724013777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013779 Pirin-related protein [General function prediction only]; Region: COG1741 1232724013780 Pirin; Region: Pirin; pfam02678 1232724013781 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1232724013782 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1232724013783 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1232724013784 dimerization interface [polypeptide binding]; other site 1232724013785 DPS ferroxidase diiron center [ion binding]; other site 1232724013786 ion pore; other site 1232724013787 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1232724013788 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1232724013789 minor groove reading motif; other site 1232724013790 helix-hairpin-helix signature motif; other site 1232724013791 active site 1232724013792 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1232724013793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1232724013794 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1232724013795 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1232724013796 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1232724013797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013798 NAD(P) binding site [chemical binding]; other site 1232724013799 active site 1232724013800 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724013801 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1232724013802 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1232724013803 Cytochrome P450; Region: p450; cl12078 1232724013804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013806 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1232724013807 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724013808 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1232724013809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724013810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013811 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724013812 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1232724013813 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724013814 hydrophobic ligand binding site; other site 1232724013815 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1232724013816 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1232724013817 putative di-iron ligands [ion binding]; other site 1232724013818 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1232724013819 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1232724013820 FAD binding pocket [chemical binding]; other site 1232724013821 FAD binding motif [chemical binding]; other site 1232724013822 phosphate binding motif [ion binding]; other site 1232724013823 beta-alpha-beta structure motif; other site 1232724013824 NAD binding pocket [chemical binding]; other site 1232724013825 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232724013826 catalytic loop [active] 1232724013827 iron binding site [ion binding]; other site 1232724013828 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1232724013829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724013830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1232724013831 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1232724013832 Coenzyme A binding pocket [chemical binding]; other site 1232724013833 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1232724013834 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1232724013835 Hemerythrin-like domain; Region: Hr-like; cd12108 1232724013836 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1232724013837 dimanganese center [ion binding]; other site 1232724013838 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1232724013839 GAF domain; Region: GAF; pfam01590 1232724013840 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1232724013841 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1232724013842 putative active site [active] 1232724013843 putative catalytic site [active] 1232724013844 Domain of unknown function DUF302; Region: DUF302; pfam03625 1232724013845 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1232724013846 active site 1232724013847 metal binding site [ion binding]; metal-binding site 1232724013848 homotetramer interface [polypeptide binding]; other site 1232724013849 MarR family; Region: MarR_2; pfam12802 1232724013850 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1232724013851 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265 1232724013852 Walker A/P-loop; other site 1232724013853 ATP binding site [chemical binding]; other site 1232724013854 Q-loop/lid; other site 1232724013855 ABC transporter signature motif; other site 1232724013856 Walker B; other site 1232724013857 D-loop; other site 1232724013858 H-loop/switch region; other site 1232724013859 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1232724013860 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232724013861 Predicted esterase [General function prediction only]; Region: COG0627 1232724013862 Predicted membrane protein [Function unknown]; Region: COG3619 1232724013863 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1232724013864 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1232724013865 trehalose synthase; Region: treS_nterm; TIGR02456 1232724013866 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1232724013867 active site 1232724013868 catalytic site [active] 1232724013869 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1232724013870 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1232724013871 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1232724013872 protein binding site [polypeptide binding]; other site 1232724013873 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1232724013874 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1232724013875 elongation factor G; Reviewed; Region: PRK12740 1232724013876 G1 box; other site 1232724013877 putative GEF interaction site [polypeptide binding]; other site 1232724013878 GTP/Mg2+ binding site [chemical binding]; other site 1232724013879 Switch I region; other site 1232724013880 G2 box; other site 1232724013881 G3 box; other site 1232724013882 Switch II region; other site 1232724013883 G4 box; other site 1232724013884 G5 box; other site 1232724013885 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1232724013886 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1232724013887 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1232724013888 acyl-CoA synthetase; Validated; Region: PRK05852 1232724013889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013890 acyl-activating enzyme (AAE) consensus motif; other site 1232724013891 AMP binding site [chemical binding]; other site 1232724013892 active site 1232724013893 CoA binding site [chemical binding]; other site 1232724013894 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1232724013895 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232724013896 PYR/PP interface [polypeptide binding]; other site 1232724013897 dimer interface [polypeptide binding]; other site 1232724013898 TPP binding site [chemical binding]; other site 1232724013899 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724013900 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1232724013901 TPP-binding site; other site 1232724013902 dimer interface [polypeptide binding]; other site 1232724013903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232724013904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724013905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1232724013906 dimerization interface [polypeptide binding]; other site 1232724013907 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1232724013908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1232724013909 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1232724013910 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1232724013911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013912 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013913 acyl-activating enzyme (AAE) consensus motif; other site 1232724013914 acyl-activating enzyme (AAE) consensus motif; other site 1232724013915 AMP binding site [chemical binding]; other site 1232724013916 active site 1232724013917 CoA binding site [chemical binding]; other site 1232724013918 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1232724013919 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1232724013920 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1232724013921 putative NAD(P) binding site [chemical binding]; other site 1232724013922 active site 1232724013923 putative substrate binding site [chemical binding]; other site 1232724013924 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1232724013925 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1232724013926 putative NAD(P) binding site [chemical binding]; other site 1232724013927 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1232724013928 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1232724013929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724013930 S-adenosylmethionine binding site [chemical binding]; other site 1232724013931 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724013932 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1232724013933 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1232724013934 active site 1232724013935 catalytic triad [active] 1232724013936 oxyanion hole [active] 1232724013937 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1232724013938 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1232724013939 NAD binding site [chemical binding]; other site 1232724013940 catalytic residues [active] 1232724013941 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1232724013942 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1232724013943 PYR/PP interface [polypeptide binding]; other site 1232724013944 dimer interface [polypeptide binding]; other site 1232724013945 TPP binding site [chemical binding]; other site 1232724013946 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232724013947 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1232724013948 TPP-binding site; other site 1232724013949 dimer interface [polypeptide binding]; other site 1232724013950 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724013951 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724013952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724013953 NAD(P) binding site [chemical binding]; other site 1232724013954 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1232724013955 active site 1232724013956 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724013957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724013958 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724013959 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724013960 [2Fe-2S] cluster binding site [ion binding]; other site 1232724013961 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1232724013962 putative alpha subunit interface [polypeptide binding]; other site 1232724013963 putative active site [active] 1232724013964 putative substrate binding site [chemical binding]; other site 1232724013965 Fe binding site [ion binding]; other site 1232724013966 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1232724013967 classical (c) SDRs; Region: SDR_c; cd05233 1232724013968 NAD(P) binding site [chemical binding]; other site 1232724013969 active site 1232724013970 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1232724013971 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1232724013972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1232724013973 DNA-binding site [nucleotide binding]; DNA binding site 1232724013974 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1232724013975 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1232724013976 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1232724013977 acyl-activating enzyme (AAE) consensus motif; other site 1232724013978 putative AMP binding site [chemical binding]; other site 1232724013979 putative active site [active] 1232724013980 putative CoA binding site [chemical binding]; other site 1232724013981 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1232724013982 classical (c) SDRs; Region: SDR_c; cd05233 1232724013983 NAD(P) binding site [chemical binding]; other site 1232724013984 active site 1232724013985 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1232724013986 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724013987 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1232724013988 acyl-activating enzyme (AAE) consensus motif; other site 1232724013989 acyl-activating enzyme (AAE) consensus motif; other site 1232724013990 putative AMP binding site [chemical binding]; other site 1232724013991 putative active site [active] 1232724013992 putative CoA binding site [chemical binding]; other site 1232724013993 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1232724013994 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1232724013995 NAD binding site [chemical binding]; other site 1232724013996 catalytic Zn binding site [ion binding]; other site 1232724013997 substrate binding site [chemical binding]; other site 1232724013998 structural Zn binding site [ion binding]; other site 1232724013999 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1232724014000 hydrophobic ligand binding site; other site 1232724014001 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232724014002 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1232724014003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724014004 NAD(P) binding site [chemical binding]; other site 1232724014005 active site 1232724014006 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1232724014007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724014008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724014009 DNA binding residues [nucleotide binding] 1232724014010 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1232724014011 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724014012 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1232724014013 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1232724014014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232724014015 motif II; other site 1232724014016 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1232724014017 acyl-CoA synthetase; Provisional; Region: PRK13383 1232724014018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724014019 acyl-activating enzyme (AAE) consensus motif; other site 1232724014020 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724014021 AMP binding site [chemical binding]; other site 1232724014022 active site 1232724014023 acyl-activating enzyme (AAE) consensus motif; other site 1232724014024 CoA binding site [chemical binding]; other site 1232724014025 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1232724014026 classical (c) SDRs; Region: SDR_c; cd05233 1232724014027 NAD(P) binding site [chemical binding]; other site 1232724014028 active site 1232724014029 Cutinase; Region: Cutinase; pfam01083 1232724014030 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1232724014031 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1232724014032 putative NAD(P) binding site [chemical binding]; other site 1232724014033 active site 1232724014034 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1232724014035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724014036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724014037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724014038 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1232724014039 cyclase homology domain; Region: CHD; cd07302 1232724014040 nucleotidyl binding site; other site 1232724014041 metal binding site [ion binding]; metal-binding site 1232724014042 dimer interface [polypeptide binding]; other site 1232724014043 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724014044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724014045 S-adenosylmethionine binding site [chemical binding]; other site 1232724014046 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1232724014047 hydrophobic ligand binding site; other site 1232724014048 short chain dehydrogenase; Validated; Region: PRK08264 1232724014049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724014050 NAD(P) binding site [chemical binding]; other site 1232724014051 active site 1232724014052 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1232724014053 CGNR zinc finger; Region: zf-CGNR; pfam11706 1232724014054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232724014055 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1232724014056 S-adenosylmethionine binding site [chemical binding]; other site 1232724014057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724014058 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1232724014059 NAD(P) binding site [chemical binding]; other site 1232724014060 active site 1232724014061 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232724014062 CoenzymeA binding site [chemical binding]; other site 1232724014063 subunit interaction site [polypeptide binding]; other site 1232724014064 PHB binding site; other site 1232724014065 Predicted membrane protein [Function unknown]; Region: COG3305 1232724014066 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1232724014067 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1232724014068 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1232724014069 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1232724014070 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1232724014071 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1232724014072 putative NAD(P) binding site [chemical binding]; other site 1232724014073 catalytic Zn binding site [ion binding]; other site 1232724014074 SnoaL-like domain; Region: SnoaL_4; pfam13577 1232724014075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724014076 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1232724014077 NAD(P) binding site [chemical binding]; other site 1232724014078 active site 1232724014079 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1232724014080 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1232724014081 short chain dehydrogenase; Provisional; Region: PRK06940 1232724014082 classical (c) SDRs; Region: SDR_c; cd05233 1232724014083 NAD(P) binding site [chemical binding]; other site 1232724014084 active site 1232724014085 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1232724014086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1232724014087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724014088 Protein of unknown function, DUF417; Region: DUF417; cl01162 1232724014089 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1232724014090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724014091 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1232724014092 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1232724014093 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1232724014094 putative hydrophobic ligand binding site [chemical binding]; other site 1232724014095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232724014096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232724014097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232724014098 dimerization interface [polypeptide binding]; other site 1232724014099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232724014100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232724014101 NAD(P) binding site [chemical binding]; other site 1232724014102 active site 1232724014103 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1232724014104 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1232724014105 classical (c) SDRs; Region: SDR_c; cd05233 1232724014106 NAD(P) binding site [chemical binding]; other site 1232724014107 active site 1232724014108 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1232724014109 classical (c) SDRs; Region: SDR_c; cd05233 1232724014110 NAD(P) binding site [chemical binding]; other site 1232724014111 active site 1232724014112 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232724014113 metal-binding site [ion binding] 1232724014114 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232724014115 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1232724014116 metal-binding site [ion binding] 1232724014117 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232724014118 Predicted esterase [General function prediction only]; Region: COG0627 1232724014119 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1232724014120 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1232724014121 NodB motif; other site 1232724014122 active site 1232724014123 catalytic site [active] 1232724014124 metal binding site [ion binding]; metal-binding site 1232724014125 Secretory lipase; Region: LIP; pfam03583 1232724014126 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1232724014127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1232724014128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724014129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724014130 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1232724014131 classical (c) SDRs; Region: SDR_c; cd05233 1232724014132 NAD(P) binding site [chemical binding]; other site 1232724014133 active site 1232724014134 acyl-CoA synthetase; Provisional; Region: PRK13388 1232724014135 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232724014136 acyl-activating enzyme (AAE) consensus motif; other site 1232724014137 AMP binding site [chemical binding]; other site 1232724014138 active site 1232724014139 CoA binding site [chemical binding]; other site 1232724014140 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724014141 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724014142 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724014143 active site 1232724014144 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724014145 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724014146 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1232724014147 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1232724014148 Amidohydrolase; Region: Amidohydro_2; pfam04909 1232724014149 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1232724014150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1232724014151 DNA binding site [nucleotide binding] 1232724014152 domain linker motif; other site 1232724014153 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1232724014154 dimerization interface [polypeptide binding]; other site 1232724014155 ligand binding site [chemical binding]; other site 1232724014156 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1232724014157 DUF35 OB-fold domain; Region: DUF35; pfam01796 1232724014158 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1232724014159 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1232724014160 active site 1232724014161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724014162 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232724014163 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724014164 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1232724014165 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1232724014166 active site 1232724014167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724014168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724014169 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1232724014170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724014171 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1232724014172 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1232724014173 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1232724014174 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1232724014175 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 1232724014176 putative active site [active] 1232724014177 catalytic residue [active] 1232724014178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232724014179 anti sigma factor interaction site; other site 1232724014180 regulatory phosphorylation site [posttranslational modification]; other site 1232724014181 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1232724014182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1232724014183 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1232724014184 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724014185 putative active site [active] 1232724014186 ATP binding site [chemical binding]; other site 1232724014187 putative substrate binding site [chemical binding]; other site 1232724014188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1232724014189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1232724014190 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1232724014191 Phosphotransferase enzyme family; Region: APH; pfam01636 1232724014192 Ecdysteroid kinase; Region: EcKinase; cl17738 1232724014193 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1232724014194 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1232724014195 active site 1232724014196 putative substrate binding pocket [chemical binding]; other site 1232724014197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232724014198 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1232724014199 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1232724014200 [2Fe-2S] cluster binding site [ion binding]; other site 1232724014201 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1232724014202 putative alpha subunit interface [polypeptide binding]; other site 1232724014203 putative active site [active] 1232724014204 putative substrate binding site [chemical binding]; other site 1232724014205 Fe binding site [ion binding]; other site 1232724014206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1232724014207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232724014208 active site 1232724014209 phosphorylation site [posttranslational modification] 1232724014210 intermolecular recognition site; other site 1232724014211 dimerization interface [polypeptide binding]; other site 1232724014212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1232724014213 DNA binding residues [nucleotide binding] 1232724014214 dimerization interface [polypeptide binding]; other site 1232724014215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1232724014216 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1232724014217 Transport protein; Region: actII; TIGR00833 1232724014218 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1232724014219 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724014220 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1232724014221 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724014222 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232724014223 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1232724014224 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1232724014225 catalytic residue [active] 1232724014226 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1232724014227 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1232724014228 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1232724014229 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1232724014230 active site 1232724014231 NTP binding site [chemical binding]; other site 1232724014232 metal binding triad [ion binding]; metal-binding site 1232724014233 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1232724014234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232724014235 Zn2+ binding site [ion binding]; other site 1232724014236 Mg2+ binding site [ion binding]; other site 1232724014237 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1232724014238 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1232724014239 active site 1232724014240 Ap6A binding site [chemical binding]; other site 1232724014241 nudix motif; other site 1232724014242 metal binding site [ion binding]; metal-binding site 1232724014243 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1232724014244 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1232724014245 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1232724014246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232724014247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232724014248 DNA binding residues [nucleotide binding] 1232724014249 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1232724014250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232724014251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232724014252 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1232724014253 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1232724014254 ParB-like nuclease domain; Region: ParBc; pfam02195 1232724014255 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1232724014256 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232724014257 P-loop; other site 1232724014258 Magnesium ion binding site [ion binding]; other site 1232724014259 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232724014260 Magnesium ion binding site [ion binding]; other site 1232724014261 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1232724014262 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1232724014263 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1232724014264 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1232724014265 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1232724014266 G-X-X-G motif; other site 1232724014267 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1232724014268 RxxxH motif; other site 1232724014269 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1232724014270 Ribonuclease P; Region: Ribonuclease_P; cl00457