-- dump date 20140619_152434 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1138382000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1138382000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382000003 Walker A motif; other site 1138382000004 ATP binding site [chemical binding]; other site 1138382000005 Walker B motif; other site 1138382000006 arginine finger; other site 1138382000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1138382000008 DnaA box-binding interface [nucleotide binding]; other site 1138382000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1138382000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1138382000011 putative DNA binding surface [nucleotide binding]; other site 1138382000012 dimer interface [polypeptide binding]; other site 1138382000013 beta-clamp/clamp loader binding surface; other site 1138382000014 beta-clamp/translesion DNA polymerase binding surface; other site 1138382000015 recombination protein F; Reviewed; Region: recF; PRK00064 1138382000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1138382000017 Walker A/P-loop; other site 1138382000018 ATP binding site [chemical binding]; other site 1138382000019 Q-loop/lid; other site 1138382000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382000021 ABC transporter signature motif; other site 1138382000022 Walker B; other site 1138382000023 D-loop; other site 1138382000024 H-loop/switch region; other site 1138382000025 hypothetical protein; Provisional; Region: PRK03195 1138382000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1138382000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382000028 Mg2+ binding site [ion binding]; other site 1138382000029 G-X-G motif; other site 1138382000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1138382000031 anchoring element; other site 1138382000032 dimer interface [polypeptide binding]; other site 1138382000033 ATP binding site [chemical binding]; other site 1138382000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1138382000035 active site 1138382000036 putative metal-binding site [ion binding]; other site 1138382000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1138382000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1138382000039 CAP-like domain; other site 1138382000040 active site 1138382000041 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138382000042 protein-splicing catalytic site; other site 1138382000043 thioester formation/cholesterol transfer; other site 1138382000044 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1138382000045 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1138382000046 DNA gyrase subunit A; Validated; Region: PRK05560 1138382000047 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1138382000048 primary dimer interface [polypeptide binding]; other site 1138382000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138382000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138382000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138382000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138382000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138382000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138382000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1138382000056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382000059 Cytochrome P450; Region: p450; cl12078 1138382000060 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1138382000061 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138382000062 active site 1138382000063 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138382000064 putative septation inhibitor protein; Reviewed; Region: PRK00159 1138382000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138382000066 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138382000067 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1138382000068 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1138382000069 glutamine binding [chemical binding]; other site 1138382000070 catalytic triad [active] 1138382000071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138382000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382000073 active site 1138382000074 ATP binding site [chemical binding]; other site 1138382000075 substrate binding site [chemical binding]; other site 1138382000076 activation loop (A-loop); other site 1138382000077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1138382000078 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138382000079 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138382000080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138382000081 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138382000082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382000083 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382000084 active site 1138382000085 ATP binding site [chemical binding]; other site 1138382000086 substrate binding site [chemical binding]; other site 1138382000087 activation loop (A-loop); other site 1138382000088 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138382000089 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138382000090 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1138382000091 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1138382000092 active site 1138382000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382000094 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382000095 phosphopeptide binding site; other site 1138382000096 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1138382000097 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382000098 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382000099 phosphopeptide binding site; other site 1138382000100 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382000101 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138382000102 DinB superfamily; Region: DinB_2; pfam12867 1138382000103 acyl carrier protein; Validated; Region: PRK05883 1138382000104 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1138382000105 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382000106 acyl-activating enzyme (AAE) consensus motif; other site 1138382000107 AMP binding site [chemical binding]; other site 1138382000108 active site 1138382000109 CoA binding site [chemical binding]; other site 1138382000110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138382000111 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138382000112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382000113 Coenzyme A binding pocket [chemical binding]; other site 1138382000114 Pirin-related protein [General function prediction only]; Region: COG1741 1138382000115 Pirin; Region: Pirin; pfam02678 1138382000116 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1138382000117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382000118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382000119 active site 1138382000120 Transcription factor WhiB; Region: Whib; pfam02467 1138382000121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382000122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382000123 non-specific DNA binding site [nucleotide binding]; other site 1138382000124 salt bridge; other site 1138382000125 sequence-specific DNA binding site [nucleotide binding]; other site 1138382000126 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138382000127 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138382000128 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138382000129 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138382000130 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1138382000131 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1138382000132 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1138382000133 TIGR03084 family protein; Region: TIGR03084 1138382000134 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382000135 Wyosine base formation; Region: Wyosine_form; pfam08608 1138382000136 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138382000137 hypothetical protein; Validated; Region: PRK00228 1138382000138 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138382000139 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1138382000140 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382000141 active site 1138382000142 HIGH motif; other site 1138382000143 nucleotide binding site [chemical binding]; other site 1138382000144 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138382000145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382000146 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382000147 active site 1138382000148 KMSKS motif; other site 1138382000149 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1138382000150 tRNA binding surface [nucleotide binding]; other site 1138382000151 short chain dehydrogenase; Provisional; Region: PRK08219 1138382000152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382000153 NAD(P) binding site [chemical binding]; other site 1138382000154 active site 1138382000155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382000156 MarR family; Region: MarR; pfam01047 1138382000157 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1138382000158 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1138382000159 Walker A/P-loop; other site 1138382000160 ATP binding site [chemical binding]; other site 1138382000161 Q-loop/lid; other site 1138382000162 ABC transporter signature motif; other site 1138382000163 Walker B; other site 1138382000164 D-loop; other site 1138382000165 H-loop/switch region; other site 1138382000166 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138382000167 substrate binding pocket [chemical binding]; other site 1138382000168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1138382000169 membrane-bound complex binding site; other site 1138382000170 hinge residues; other site 1138382000171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382000172 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1138382000173 dimer interface [polypeptide binding]; other site 1138382000174 conserved gate region; other site 1138382000175 putative PBP binding loops; other site 1138382000176 ABC-ATPase subunit interface; other site 1138382000177 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138382000178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382000179 DNA-binding site [nucleotide binding]; DNA binding site 1138382000180 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1138382000181 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382000182 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382000183 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138382000184 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138382000185 active site 1138382000186 FMN binding site [chemical binding]; other site 1138382000187 substrate binding site [chemical binding]; other site 1138382000188 putative catalytic residue [active] 1138382000189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382000190 NAD(P) binding site [chemical binding]; other site 1138382000191 active site 1138382000192 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382000193 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138382000194 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1138382000195 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382000196 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382000197 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1138382000198 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1138382000199 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138382000200 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138382000201 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138382000202 Transglycosylase; Region: Transgly; pfam00912 1138382000203 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1138382000204 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138382000205 Predicted integral membrane protein [Function unknown]; Region: COG5650 1138382000206 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138382000207 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138382000208 conserved cys residue [active] 1138382000209 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1138382000210 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138382000211 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138382000212 dimer interface [polypeptide binding]; other site 1138382000213 ssDNA binding site [nucleotide binding]; other site 1138382000214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138382000215 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1138382000216 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1138382000217 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1138382000218 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1138382000219 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1138382000220 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138382000221 Walker A motif; other site 1138382000222 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1138382000223 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1138382000224 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1138382000225 ATP binding site [chemical binding]; other site 1138382000226 Walker B motif; other site 1138382000227 DNA binding loops [nucleotide binding] 1138382000228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000230 Transport protein; Region: actII; TIGR00833 1138382000231 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382000232 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138382000233 DNA-binding site [nucleotide binding]; DNA binding site 1138382000234 RNA-binding motif; other site 1138382000235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382000236 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382000237 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138382000238 classical (c) SDRs; Region: SDR_c; cd05233 1138382000239 NAD(P) binding site [chemical binding]; other site 1138382000240 active site 1138382000241 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382000242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382000243 NAD(P) binding site [chemical binding]; other site 1138382000244 active site 1138382000245 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382000246 Cytochrome P450; Region: p450; cl12078 1138382000247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382000248 short chain dehydrogenase; Provisional; Region: PRK08303 1138382000249 NAD(P) binding site [chemical binding]; other site 1138382000250 active site 1138382000251 potential frameshift: common BLAST hit: gi|54025276|ref|YP_119518.1| transposase 1138382000252 Integrase core domain; Region: rve; pfam00665 1138382000253 Integrase core domain; Region: rve_3; pfam13683 1138382000254 Homeodomain-like domain; Region: HTH_23; cl17451 1138382000255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000257 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138382000258 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138382000259 putative dimer interface [polypeptide binding]; other site 1138382000260 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382000261 classical (c) SDRs; Region: SDR_c; cd05233 1138382000262 NAD(P) binding site [chemical binding]; other site 1138382000263 active site 1138382000264 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138382000265 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382000266 Berberine and berberine like; Region: BBE; pfam08031 1138382000267 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138382000268 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138382000269 ligand binding site [chemical binding]; other site 1138382000270 flexible hinge region; other site 1138382000271 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138382000272 putative switch regulator; other site 1138382000273 non-specific DNA interactions [nucleotide binding]; other site 1138382000274 DNA binding site [nucleotide binding] 1138382000275 sequence specific DNA binding site [nucleotide binding]; other site 1138382000276 putative cAMP binding site [chemical binding]; other site 1138382000277 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382000278 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382000279 PGAP1-like protein; Region: PGAP1; pfam07819 1138382000280 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138382000281 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1138382000282 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1138382000283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382000284 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1138382000285 active site 1138382000286 Permease; Region: Permease; pfam02405 1138382000287 Permease; Region: Permease; pfam02405 1138382000288 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138382000289 mce related protein; Region: MCE; pfam02470 1138382000290 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138382000291 mce related protein; Region: MCE; pfam02470 1138382000292 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382000293 mce related protein; Region: MCE; pfam02470 1138382000294 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382000295 mce related protein; Region: MCE; pfam02470 1138382000296 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382000297 mce related protein; Region: MCE; pfam02470 1138382000298 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138382000299 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382000300 mce related protein; Region: MCE; pfam02470 1138382000301 Mannan-binding protein; Region: MVL; pfam12151 1138382000302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000306 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1138382000307 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138382000308 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382000309 PPE family; Region: PPE; pfam00823 1138382000310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382000311 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382000312 S-adenosylmethionine binding site [chemical binding]; other site 1138382000313 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382000314 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382000315 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382000316 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138382000317 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1138382000318 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138382000319 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382000320 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382000321 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1138382000322 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1138382000323 putative ligand binding site [chemical binding]; other site 1138382000324 NAD binding site [chemical binding]; other site 1138382000325 catalytic site [active] 1138382000326 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138382000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138382000328 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382000329 Cytochrome P450; Region: p450; cl12078 1138382000330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138382000331 metal ion-dependent adhesion site (MIDAS); other site 1138382000332 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138382000333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382000334 Walker A motif; other site 1138382000335 ATP binding site [chemical binding]; other site 1138382000336 Walker B motif; other site 1138382000337 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138382000338 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1138382000339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000340 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382000341 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382000343 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138382000344 putative substrate translocation pore; other site 1138382000345 Hemerythrin-like domain; Region: Hr-like; cd12108 1138382000346 Fe binding site [ion binding]; other site 1138382000347 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382000348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382000349 S-adenosylmethionine binding site [chemical binding]; other site 1138382000350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382000351 active site 1138382000352 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1138382000353 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1138382000354 putative active site [active] 1138382000355 putative CoA binding site [chemical binding]; other site 1138382000356 nudix motif; other site 1138382000357 metal binding site [ion binding]; metal-binding site 1138382000358 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1138382000359 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1138382000360 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382000361 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382000362 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138382000363 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138382000364 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1138382000365 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382000366 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138382000367 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382000368 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138382000369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382000370 hypothetical protein; Provisional; Region: PRK01346 1138382000371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382000372 Coenzyme A binding pocket [chemical binding]; other site 1138382000373 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382000374 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382000375 active site 1138382000376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382000379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382000380 dimer interface [polypeptide binding]; other site 1138382000381 phosphorylation site [posttranslational modification] 1138382000382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382000383 ATP binding site [chemical binding]; other site 1138382000384 Mg2+ binding site [ion binding]; other site 1138382000385 G-X-G motif; other site 1138382000386 PPE family; Region: PPE; pfam00823 1138382000387 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138382000388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138382000389 EspG family; Region: ESX-1_EspG; pfam14011 1138382000390 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138382000391 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138382000392 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138382000393 catalytic residues [active] 1138382000394 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138382000395 catalytic residues [active] 1138382000396 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138382000397 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138382000398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382000399 Walker A motif; other site 1138382000400 ATP binding site [chemical binding]; other site 1138382000401 Walker B motif; other site 1138382000402 arginine finger; other site 1138382000403 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138382000404 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138382000405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382000406 NAD(P) binding site [chemical binding]; other site 1138382000407 active site 1138382000408 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1138382000409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382000410 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138382000411 DNA binding residues [nucleotide binding] 1138382000412 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138382000413 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1138382000414 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1138382000415 active site 1138382000416 dimer interface [polypeptide binding]; other site 1138382000417 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1138382000418 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1138382000419 active site 1138382000420 FMN binding site [chemical binding]; other site 1138382000421 substrate binding site [chemical binding]; other site 1138382000422 3Fe-4S cluster binding site [ion binding]; other site 1138382000423 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1138382000424 domain interface; other site 1138382000425 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1138382000426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382000427 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138382000428 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382000429 hypothetical protein; Provisional; Region: PRK07945 1138382000430 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1138382000431 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1138382000432 active site 1138382000433 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1138382000434 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138382000435 DNA polymerase IV; Validated; Region: PRK03858 1138382000436 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138382000437 active site 1138382000438 DNA binding site [nucleotide binding] 1138382000439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000441 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382000442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382000443 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1138382000444 CopC domain; Region: CopC; pfam04234 1138382000445 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1138382000446 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1138382000447 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1138382000448 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1138382000449 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1138382000450 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1138382000451 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138382000452 putative active site [active] 1138382000453 catalytic site [active] 1138382000454 putative metal binding site [ion binding]; other site 1138382000455 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1138382000456 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1138382000457 prephenate dehydratase; Provisional; Region: PRK11898 1138382000458 Prephenate dehydratase; Region: PDT; pfam00800 1138382000459 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1138382000460 putative L-Phe binding site [chemical binding]; other site 1138382000461 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382000462 catalytic core [active] 1138382000463 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1138382000464 Septum formation; Region: Septum_form; pfam13845 1138382000465 Septum formation; Region: Septum_form; pfam13845 1138382000466 seryl-tRNA synthetase; Provisional; Region: PRK05431 1138382000467 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1138382000468 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1138382000469 dimer interface [polypeptide binding]; other site 1138382000470 active site 1138382000471 motif 1; other site 1138382000472 motif 2; other site 1138382000473 motif 3; other site 1138382000474 Cupin domain; Region: Cupin_2; cl17218 1138382000475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382000476 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138382000477 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382000478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382000479 S-adenosylmethionine binding site [chemical binding]; other site 1138382000480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382000481 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1138382000482 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382000483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000484 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138382000485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382000486 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1138382000487 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138382000488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138382000489 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382000490 iron-sulfur cluster [ion binding]; other site 1138382000491 [2Fe-2S] cluster binding site [ion binding]; other site 1138382000492 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382000493 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138382000494 putative acyl-acceptor binding pocket; other site 1138382000495 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382000496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138382000497 putative acyl-acceptor binding pocket; other site 1138382000498 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382000499 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138382000500 putative acyl-acceptor binding pocket; other site 1138382000501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382000502 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1138382000503 active site 1138382000504 motif I; other site 1138382000505 motif II; other site 1138382000506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382000507 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138382000508 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1138382000509 amidase catalytic site [active] 1138382000510 Zn binding residues [ion binding]; other site 1138382000511 substrate binding site [chemical binding]; other site 1138382000512 LGFP repeat; Region: LGFP; pfam08310 1138382000513 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1138382000514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382000515 UDP-galactopyranose mutase; Region: GLF; pfam03275 1138382000516 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138382000517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138382000518 active site 1138382000519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138382000520 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1138382000521 Predicted esterase [General function prediction only]; Region: COG0627 1138382000522 Putative esterase; Region: Esterase; pfam00756 1138382000523 Cutinase; Region: Cutinase; pfam01083 1138382000524 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1138382000525 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138382000526 acyl-activating enzyme (AAE) consensus motif; other site 1138382000527 active site 1138382000528 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382000529 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382000530 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138382000531 active site 1138382000532 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138382000533 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382000534 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382000535 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1138382000536 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138382000537 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138382000538 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382000539 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138382000540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382000541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382000542 DNA binding residues [nucleotide binding] 1138382000543 RibD C-terminal domain; Region: RibD_C; cl17279 1138382000544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382000545 active site 1138382000546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382000547 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138382000548 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1138382000549 ligand binding site [chemical binding]; other site 1138382000550 flexible hinge region; other site 1138382000551 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138382000552 putative switch regulator; other site 1138382000553 non-specific DNA interactions [nucleotide binding]; other site 1138382000554 DNA binding site [nucleotide binding] 1138382000555 sequence specific DNA binding site [nucleotide binding]; other site 1138382000556 putative cAMP binding site [chemical binding]; other site 1138382000557 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382000558 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382000559 phosphopeptide binding site; other site 1138382000560 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138382000561 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1138382000562 putative hydrophobic ligand binding site [chemical binding]; other site 1138382000563 CLM binding site; other site 1138382000564 L1 loop; other site 1138382000565 DNA binding site [nucleotide binding] 1138382000566 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138382000567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382000568 putative DNA binding site [nucleotide binding]; other site 1138382000569 putative Zn2+ binding site [ion binding]; other site 1138382000570 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138382000571 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1138382000572 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1138382000573 short chain dehydrogenase; Provisional; Region: PRK07904 1138382000574 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138382000575 NAD(P) binding site [chemical binding]; other site 1138382000576 active site 1138382000577 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138382000578 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382000579 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1138382000580 Predicted membrane protein [Function unknown]; Region: COG2246 1138382000581 GtrA-like protein; Region: GtrA; pfam04138 1138382000582 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1138382000583 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138382000584 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382000585 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382000586 active site 1138382000587 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1138382000588 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138382000589 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138382000590 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138382000591 active site 1138382000592 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1138382000593 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1138382000594 Walker A/P-loop; other site 1138382000595 ATP binding site [chemical binding]; other site 1138382000596 Q-loop/lid; other site 1138382000597 ABC transporter signature motif; other site 1138382000598 Walker B; other site 1138382000599 D-loop; other site 1138382000600 H-loop/switch region; other site 1138382000601 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1138382000602 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138382000603 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382000604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382000605 catalytic residue [active] 1138382000606 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1138382000607 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1138382000608 NAD(P) binding site [chemical binding]; other site 1138382000609 eRF1 domain 3; Region: eRF1_3; pfam03465 1138382000610 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382000611 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382000612 enoyl-CoA hydratase; Provisional; Region: PRK06142 1138382000613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382000614 substrate binding site [chemical binding]; other site 1138382000615 oxyanion hole (OAH) forming residues; other site 1138382000616 trimer interface [polypeptide binding]; other site 1138382000617 TIGR03086 family protein; Region: TIGR03086 1138382000618 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138382000619 GXWXG protein; Region: GXWXG; pfam14231 1138382000620 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1138382000621 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1138382000622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382000623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382000624 homodimer interface [polypeptide binding]; other site 1138382000625 catalytic residue [active] 1138382000626 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382000627 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382000628 putative active site [active] 1138382000629 putative substrate binding site [chemical binding]; other site 1138382000630 ATP binding site [chemical binding]; other site 1138382000631 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382000632 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382000633 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382000634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382000635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382000636 active site 1138382000637 phosphorylation site [posttranslational modification] 1138382000638 intermolecular recognition site; other site 1138382000639 dimerization interface [polypeptide binding]; other site 1138382000640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382000641 DNA binding site [nucleotide binding] 1138382000642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382000643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1138382000644 dimerization interface [polypeptide binding]; other site 1138382000645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382000646 dimer interface [polypeptide binding]; other site 1138382000647 phosphorylation site [posttranslational modification] 1138382000648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382000649 ATP binding site [chemical binding]; other site 1138382000650 Mg2+ binding site [ion binding]; other site 1138382000651 G-X-G motif; other site 1138382000652 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138382000653 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1138382000654 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382000655 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138382000656 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138382000657 NAD(P) binding site [chemical binding]; other site 1138382000658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382000661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382000662 active site 1138382000663 short chain dehydrogenase; Provisional; Region: PRK07035 1138382000664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382000665 NAD(P) binding site [chemical binding]; other site 1138382000666 active site 1138382000667 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382000668 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382000669 putative active site [active] 1138382000670 putative substrate binding site [chemical binding]; other site 1138382000671 ATP binding site [chemical binding]; other site 1138382000672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382000673 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382000674 catalytic core [active] 1138382000675 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382000676 putative active site [active] 1138382000677 putative substrate binding site [chemical binding]; other site 1138382000678 ATP binding site [chemical binding]; other site 1138382000679 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1138382000680 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1138382000681 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1138382000682 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1138382000683 Walker A/P-loop; other site 1138382000684 ATP binding site [chemical binding]; other site 1138382000685 Q-loop/lid; other site 1138382000686 ABC transporter signature motif; other site 1138382000687 Walker B; other site 1138382000688 D-loop; other site 1138382000689 H-loop/switch region; other site 1138382000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1138382000691 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1138382000692 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1138382000693 prephenate dehydrogenase; Validated; Region: PRK06545 1138382000694 prephenate dehydrogenase; Validated; Region: PRK08507 1138382000695 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1138382000696 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138382000697 nucleoside/Zn binding site; other site 1138382000698 dimer interface [polypeptide binding]; other site 1138382000699 catalytic motif [active] 1138382000700 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1138382000701 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1138382000702 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138382000703 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1138382000704 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1138382000705 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382000706 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382000707 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382000708 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138382000709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382000710 DNA-binding site [nucleotide binding]; DNA binding site 1138382000711 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138382000712 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138382000713 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138382000714 active site 1138382000715 non-prolyl cis peptide bond; other site 1138382000716 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382000717 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382000718 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138382000719 pyruvate carboxylase; Reviewed; Region: PRK12999 1138382000720 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382000721 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382000722 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138382000723 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1138382000724 active site 1138382000725 catalytic residues [active] 1138382000726 metal binding site [ion binding]; metal-binding site 1138382000727 homodimer binding site [polypeptide binding]; other site 1138382000728 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138382000729 carboxyltransferase (CT) interaction site; other site 1138382000730 biotinylation site [posttranslational modification]; other site 1138382000731 citrate synthase; Provisional; Region: PRK14033 1138382000732 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1138382000733 dimer interface [polypeptide binding]; other site 1138382000734 active site 1138382000735 citrylCoA binding site [chemical binding]; other site 1138382000736 oxalacetate/citrate binding site [chemical binding]; other site 1138382000737 coenzyme A binding site [chemical binding]; other site 1138382000738 catalytic triad [active] 1138382000739 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1138382000740 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138382000741 tetramer interface [polypeptide binding]; other site 1138382000742 active site 1138382000743 Mg2+/Mn2+ binding site [ion binding]; other site 1138382000744 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1138382000745 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382000746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382000747 non-specific DNA binding site [nucleotide binding]; other site 1138382000748 salt bridge; other site 1138382000749 sequence-specific DNA binding site [nucleotide binding]; other site 1138382000750 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1138382000751 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138382000752 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138382000753 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1138382000754 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138382000755 substrate binding site [chemical binding]; other site 1138382000756 ATP binding site [chemical binding]; other site 1138382000757 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1138382000758 dimerization interface [polypeptide binding]; other site 1138382000759 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1138382000760 NAD binding site [chemical binding]; other site 1138382000761 ligand binding site [chemical binding]; other site 1138382000762 catalytic site [active] 1138382000763 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382000764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000765 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382000766 classical (c) SDRs; Region: SDR_c; cd05233 1138382000767 NAD(P) binding site [chemical binding]; other site 1138382000768 active site 1138382000769 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382000770 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382000771 active site 1138382000772 metal binding site [ion binding]; metal-binding site 1138382000773 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382000774 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382000775 short chain dehydrogenase; Provisional; Region: PRK07856 1138382000776 classical (c) SDRs; Region: SDR_c; cd05233 1138382000777 NAD(P) binding site [chemical binding]; other site 1138382000778 active site 1138382000779 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382000780 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382000781 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 1138382000782 nudix motif; other site 1138382000783 haloalkane dehalogenase; Provisional; Region: PRK00870 1138382000784 Cytochrome P450; Region: p450; cl12078 1138382000785 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382000786 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382000787 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382000788 active site 1138382000789 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1138382000790 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1138382000791 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1138382000792 active site 1138382000793 DNA binding site [nucleotide binding] 1138382000794 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1138382000795 DNA binding site [nucleotide binding] 1138382000796 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138382000797 nucleotide binding site [chemical binding]; other site 1138382000798 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1138382000799 Isochorismatase family; Region: Isochorismatase; pfam00857 1138382000800 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138382000801 catalytic triad [active] 1138382000802 conserved cis-peptide bond; other site 1138382000803 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382000804 Cytochrome P450; Region: p450; cl12078 1138382000805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382000806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382000807 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138382000808 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138382000809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382000810 NAD(P) binding site [chemical binding]; other site 1138382000811 active site 1138382000812 Cutinase; Region: Cutinase; pfam01083 1138382000813 CsbD-like; Region: CsbD; pfam05532 1138382000814 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382000815 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382000816 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382000817 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382000818 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1138382000819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382000820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382000821 catalytic residue [active] 1138382000822 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1138382000823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382000824 Walker A motif; other site 1138382000825 ATP binding site [chemical binding]; other site 1138382000826 Walker B motif; other site 1138382000827 arginine finger; other site 1138382000828 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1138382000829 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382000830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382000831 S-adenosylmethionine binding site [chemical binding]; other site 1138382000832 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138382000833 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382000834 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138382000835 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138382000836 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138382000837 active site 1138382000838 metal binding site [ion binding]; metal-binding site 1138382000839 hypothetical protein; Validated; Region: PRK00153 1138382000840 recombination protein RecR; Reviewed; Region: recR; PRK00076 1138382000841 RecR protein; Region: RecR; pfam02132 1138382000842 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1138382000843 putative active site [active] 1138382000844 putative metal-binding site [ion binding]; other site 1138382000845 tetramer interface [polypeptide binding]; other site 1138382000846 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138382000847 catalytic triad [active] 1138382000848 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1138382000849 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138382000850 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1138382000851 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1138382000852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138382000853 active site 1138382000854 catalytic site [active] 1138382000855 substrate binding site [chemical binding]; other site 1138382000856 2-isopropylmalate synthase; Validated; Region: PRK03739 1138382000857 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1138382000858 active site 1138382000859 catalytic residues [active] 1138382000860 metal binding site [ion binding]; metal-binding site 1138382000861 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1138382000862 aspartate kinase; Reviewed; Region: PRK06635 1138382000863 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1138382000864 putative nucleotide binding site [chemical binding]; other site 1138382000865 putative catalytic residues [active] 1138382000866 putative Mg ion binding site [ion binding]; other site 1138382000867 putative aspartate binding site [chemical binding]; other site 1138382000868 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1138382000869 putative allosteric regulatory site; other site 1138382000870 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1138382000871 putative allosteric regulatory residue; other site 1138382000872 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1138382000873 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138382000874 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138382000875 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382000876 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 1138382000877 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1138382000878 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138382000879 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1138382000880 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138382000881 putative active site [active] 1138382000882 putative dimer interface [polypeptide binding]; other site 1138382000883 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1138382000884 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1138382000885 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382000886 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138382000887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382000888 catalytic residue [active] 1138382000889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382000890 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382000891 S-adenosylmethionine binding site [chemical binding]; other site 1138382000892 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382000893 nucleotide binding site [chemical binding]; other site 1138382000894 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382000895 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138382000896 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138382000897 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1138382000898 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1138382000899 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138382000900 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138382000901 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138382000902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382000903 Walker A motif; other site 1138382000904 ATP binding site [chemical binding]; other site 1138382000905 Walker B motif; other site 1138382000906 arginine finger; other site 1138382000907 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138382000908 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1138382000909 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138382000910 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382000911 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1138382000912 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1138382000913 proposed catalytic triad [active] 1138382000914 conserved cys residue [active] 1138382000915 putative methyltransferase; Provisional; Region: PRK14967 1138382000916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382000917 S-adenosylmethionine binding site [chemical binding]; other site 1138382000918 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1138382000919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138382000920 PAS domain; Region: PAS_9; pfam13426 1138382000921 putative active site [active] 1138382000922 heme pocket [chemical binding]; other site 1138382000923 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138382000924 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138382000925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138382000926 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1138382000927 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138382000928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382000929 ATP binding site [chemical binding]; other site 1138382000930 Mg2+ binding site [ion binding]; other site 1138382000931 G-X-G motif; other site 1138382000932 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1138382000933 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1138382000934 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1138382000935 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382000936 anti sigma factor interaction site; other site 1138382000937 regulatory phosphorylation site [posttranslational modification]; other site 1138382000938 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1138382000939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382000940 motif II; other site 1138382000941 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1138382000942 Restriction endonuclease; Region: Mrr_cat; pfam04471 1138382000943 AAA ATPase domain; Region: AAA_16; pfam13191 1138382000944 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138382000945 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1138382000946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382000947 catalytic residue [active] 1138382000948 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1138382000949 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1138382000950 putative active site [active] 1138382000951 putative metal binding site [ion binding]; other site 1138382000952 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1138382000953 Transglycosylase; Region: Transgly; pfam00912 1138382000954 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1138382000955 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138382000956 Transcription factor WhiB; Region: Whib; pfam02467 1138382000957 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138382000958 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138382000959 DTAP/Switch II; other site 1138382000960 Switch I; other site 1138382000961 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138382000962 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138382000963 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138382000964 P loop; other site 1138382000965 Nucleotide binding site [chemical binding]; other site 1138382000966 DTAP/Switch II; other site 1138382000967 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1138382000968 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1138382000969 homotrimer interaction site [polypeptide binding]; other site 1138382000970 putative active site [active] 1138382000971 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382000972 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138382000973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138382000974 ligand binding site [chemical binding]; other site 1138382000975 flexible hinge region; other site 1138382000976 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138382000977 putative switch regulator; other site 1138382000978 non-specific DNA interactions [nucleotide binding]; other site 1138382000979 DNA binding site [nucleotide binding] 1138382000980 sequence specific DNA binding site [nucleotide binding]; other site 1138382000981 putative cAMP binding site [chemical binding]; other site 1138382000982 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1138382000983 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138382000984 minor groove reading motif; other site 1138382000985 helix-hairpin-helix signature motif; other site 1138382000986 substrate binding pocket [chemical binding]; other site 1138382000987 active site 1138382000988 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1138382000989 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138382000990 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138382000991 catalytic residues [active] 1138382000992 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1138382000993 putative active site [active] 1138382000994 putative CoA binding site [chemical binding]; other site 1138382000995 nudix motif; other site 1138382000996 metal binding site [ion binding]; metal-binding site 1138382000997 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138382000998 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138382000999 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382001000 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1138382001001 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138382001002 acetyl-CoA synthetase; Provisional; Region: PRK00174 1138382001003 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1138382001004 active site 1138382001005 CoA binding site [chemical binding]; other site 1138382001006 acyl-activating enzyme (AAE) consensus motif; other site 1138382001007 AMP binding site [chemical binding]; other site 1138382001008 acetate binding site [chemical binding]; other site 1138382001009 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1138382001010 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1138382001011 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1138382001012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1138382001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382001014 dimer interface [polypeptide binding]; other site 1138382001015 conserved gate region; other site 1138382001016 ABC-ATPase subunit interface; other site 1138382001017 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1138382001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382001019 dimer interface [polypeptide binding]; other site 1138382001020 conserved gate region; other site 1138382001021 putative PBP binding loops; other site 1138382001022 ABC-ATPase subunit interface; other site 1138382001023 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1138382001024 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138382001025 Walker A/P-loop; other site 1138382001026 ATP binding site [chemical binding]; other site 1138382001027 Q-loop/lid; other site 1138382001028 ABC transporter signature motif; other site 1138382001029 Walker B; other site 1138382001030 D-loop; other site 1138382001031 H-loop/switch region; other site 1138382001032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138382001033 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138382001034 Walker A/P-loop; other site 1138382001035 ATP binding site [chemical binding]; other site 1138382001036 Q-loop/lid; other site 1138382001037 ABC transporter signature motif; other site 1138382001038 Walker B; other site 1138382001039 D-loop; other site 1138382001040 H-loop/switch region; other site 1138382001041 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138382001042 Fic family protein [Function unknown]; Region: COG3177 1138382001043 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138382001044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382001045 motif II; other site 1138382001046 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1138382001047 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1138382001048 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1138382001049 hexamer interface [polypeptide binding]; other site 1138382001050 Walker B motif; other site 1138382001051 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1138382001052 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1138382001053 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1138382001054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382001055 ATP binding site [chemical binding]; other site 1138382001056 putative Mg++ binding site [ion binding]; other site 1138382001057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382001058 nucleotide binding region [chemical binding]; other site 1138382001059 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1138382001060 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138382001061 DNA-binding site [nucleotide binding]; DNA binding site 1138382001062 RNA-binding motif; other site 1138382001063 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1138382001064 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1138382001065 active site 1138382001066 interdomain interaction site; other site 1138382001067 putative metal-binding site [ion binding]; other site 1138382001068 nucleotide binding site [chemical binding]; other site 1138382001069 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1138382001070 domain I; other site 1138382001071 phosphate binding site [ion binding]; other site 1138382001072 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1138382001073 domain II; other site 1138382001074 domain III; other site 1138382001075 nucleotide binding site [chemical binding]; other site 1138382001076 DNA binding groove [nucleotide binding] 1138382001077 catalytic site [active] 1138382001078 domain IV; other site 1138382001079 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138382001080 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138382001081 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138382001082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138382001083 dimerization interface [polypeptide binding]; other site 1138382001084 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382001085 cyclase homology domain; Region: CHD; cd07302 1138382001086 nucleotidyl binding site; other site 1138382001087 metal binding site [ion binding]; metal-binding site 1138382001088 dimer interface [polypeptide binding]; other site 1138382001089 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1138382001090 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1138382001091 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382001092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001093 NAD(P) binding site [chemical binding]; other site 1138382001094 active site 1138382001095 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138382001096 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138382001097 Ligand binding site; other site 1138382001098 Putative Catalytic site; other site 1138382001099 DXD motif; other site 1138382001100 Protein of unknown function (DUF475); Region: DUF475; pfam04332 1138382001101 potential frameshift: common BLAST hit: gi|375141561|ref|YP_005002210.1| transposase 1138382001102 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382001103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382001104 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382001105 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1138382001106 dimer interface [polypeptide binding]; other site 1138382001107 substrate binding site [chemical binding]; other site 1138382001108 metal binding sites [ion binding]; metal-binding site 1138382001109 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1138382001110 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1138382001111 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138382001112 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1138382001113 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1138382001114 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1138382001115 Ligand Binding Site [chemical binding]; other site 1138382001116 TilS substrate binding domain; Region: TilS; pfam09179 1138382001117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382001118 active site 1138382001119 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1138382001120 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1138382001121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382001122 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382001123 salt bridge; other site 1138382001124 non-specific DNA binding site [nucleotide binding]; other site 1138382001125 sequence-specific DNA binding site [nucleotide binding]; other site 1138382001126 PE family; Region: PE; pfam00934 1138382001127 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382001128 PPE family; Region: PPE; pfam00823 1138382001129 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382001130 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382001131 active site 1138382001132 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382001133 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1138382001134 putative NAD(P) binding site [chemical binding]; other site 1138382001135 catalytic Zn binding site [ion binding]; other site 1138382001136 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382001137 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138382001138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382001139 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382001140 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138382001141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382001142 active site 1138382001143 metal binding site [ion binding]; metal-binding site 1138382001144 FtsH Extracellular; Region: FtsH_ext; pfam06480 1138382001145 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1138382001146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382001147 Walker A motif; other site 1138382001148 ATP binding site [chemical binding]; other site 1138382001149 Walker B motif; other site 1138382001150 arginine finger; other site 1138382001151 Peptidase family M41; Region: Peptidase_M41; pfam01434 1138382001152 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1138382001153 homodecamer interface [polypeptide binding]; other site 1138382001154 GTP cyclohydrolase I; Provisional; Region: PLN03044 1138382001155 active site 1138382001156 putative catalytic site residues [active] 1138382001157 zinc binding site [ion binding]; other site 1138382001158 GTP-CH-I/GFRP interaction surface; other site 1138382001159 dihydropteroate synthase; Region: DHPS; TIGR01496 1138382001160 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1138382001161 substrate binding pocket [chemical binding]; other site 1138382001162 dimer interface [polypeptide binding]; other site 1138382001163 inhibitor binding site; inhibition site 1138382001164 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1138382001165 active site 1138382001166 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1138382001167 catalytic center binding site [active] 1138382001168 ATP binding site [chemical binding]; other site 1138382001169 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1138382001170 Rossmann-like domain; Region: Rossmann-like; pfam10727 1138382001171 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1138382001172 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1138382001173 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1138382001174 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1138382001175 active site 1138382001176 ATP-binding site [chemical binding]; other site 1138382001177 pantoate-binding site; other site 1138382001178 HXXH motif; other site 1138382001179 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1138382001180 tetramerization interface [polypeptide binding]; other site 1138382001181 active site 1138382001182 pantothenate kinase; Reviewed; Region: PRK13318 1138382001183 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1138382001184 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138382001185 dimer interface [polypeptide binding]; other site 1138382001186 putative anticodon binding site; other site 1138382001187 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138382001188 motif 1; other site 1138382001189 dimer interface [polypeptide binding]; other site 1138382001190 active site 1138382001191 motif 2; other site 1138382001192 motif 3; other site 1138382001193 Lsr2; Region: Lsr2; pfam11774 1138382001194 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1138382001195 Clp amino terminal domain; Region: Clp_N; pfam02861 1138382001196 Clp amino terminal domain; Region: Clp_N; pfam02861 1138382001197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382001198 Walker A motif; other site 1138382001199 ATP binding site [chemical binding]; other site 1138382001200 Walker B motif; other site 1138382001201 arginine finger; other site 1138382001202 UvrB/uvrC motif; Region: UVR; pfam02151 1138382001203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382001204 Walker A motif; other site 1138382001205 ATP binding site [chemical binding]; other site 1138382001206 Walker B motif; other site 1138382001207 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138382001208 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1138382001209 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1138382001210 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1138382001211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382001212 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138382001213 catalytic site [active] 1138382001214 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1138382001215 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138382001216 minor groove reading motif; other site 1138382001217 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138382001218 helix-hairpin-helix signature motif; other site 1138382001219 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1138382001220 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1138382001221 active site clefts [active] 1138382001222 zinc binding site [ion binding]; other site 1138382001223 dimer interface [polypeptide binding]; other site 1138382001224 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1138382001225 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1138382001226 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1138382001227 DNA repair protein RadA; Provisional; Region: PRK11823 1138382001228 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1138382001229 Walker A motif/ATP binding site; other site 1138382001230 ATP binding site [chemical binding]; other site 1138382001231 Walker B motif; other site 1138382001232 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138382001233 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1138382001234 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1138382001235 substrate binding site; other site 1138382001236 dimer interface; other site 1138382001237 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1138382001238 homotrimer interaction site [polypeptide binding]; other site 1138382001239 zinc binding site [ion binding]; other site 1138382001240 CDP-binding sites; other site 1138382001241 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1138382001242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382001243 active site 1138382001244 HIGH motif; other site 1138382001245 nucleotide binding site [chemical binding]; other site 1138382001246 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1138382001247 KMSKS motif; other site 1138382001248 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1138382001249 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138382001250 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1138382001251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138382001252 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1138382001253 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138382001254 active site 1138382001255 catalytic site [active] 1138382001256 metal binding site [ion binding]; metal-binding site 1138382001257 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1138382001258 transmembrane helices; other site 1138382001259 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138382001260 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138382001261 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1138382001262 putative active site [active] 1138382001263 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382001264 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1138382001265 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1138382001266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382001267 Walker A/P-loop; other site 1138382001268 ATP binding site [chemical binding]; other site 1138382001269 Q-loop/lid; other site 1138382001270 ABC transporter signature motif; other site 1138382001271 Walker B; other site 1138382001272 D-loop; other site 1138382001273 H-loop/switch region; other site 1138382001274 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138382001275 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1138382001276 intersubunit interface [polypeptide binding]; other site 1138382001277 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1138382001278 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1138382001279 DNA binding site [nucleotide binding] 1138382001280 domain linker motif; other site 1138382001281 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1138382001282 putative dimerization interface [polypeptide binding]; other site 1138382001283 putative ligand binding site [chemical binding]; other site 1138382001284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001286 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001287 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382001288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001290 active site 1138382001291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001292 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001293 active site 1138382001294 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382001295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001296 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1138382001297 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382001298 putative NAD(P) binding site [chemical binding]; other site 1138382001299 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138382001300 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138382001301 FAD binding pocket [chemical binding]; other site 1138382001302 FAD binding motif [chemical binding]; other site 1138382001303 phosphate binding motif [ion binding]; other site 1138382001304 beta-alpha-beta structure motif; other site 1138382001305 NAD(p) ribose binding residues [chemical binding]; other site 1138382001306 NAD binding pocket [chemical binding]; other site 1138382001307 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138382001308 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382001309 catalytic loop [active] 1138382001310 iron binding site [ion binding]; other site 1138382001311 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001312 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1138382001313 Flavin binding site [chemical binding]; other site 1138382001314 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1138382001315 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138382001316 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138382001317 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1138382001318 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1138382001319 active site 1138382001320 Fe binding site [ion binding]; other site 1138382001321 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138382001322 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1138382001323 aspartate aminotransferase; Provisional; Region: PRK05764 1138382001324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382001325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382001326 homodimer interface [polypeptide binding]; other site 1138382001327 catalytic residue [active] 1138382001328 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382001329 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001331 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138382001332 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382001333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001334 active site 1138382001335 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001336 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001337 active site 1138382001338 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1138382001339 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382001340 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138382001341 acyl-activating enzyme (AAE) consensus motif; other site 1138382001342 acyl-activating enzyme (AAE) consensus motif; other site 1138382001343 putative AMP binding site [chemical binding]; other site 1138382001344 putative active site [active] 1138382001345 putative CoA binding site [chemical binding]; other site 1138382001346 CoA binding site [chemical binding]; other site 1138382001347 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001349 active site 1138382001350 short chain dehydrogenase; Provisional; Region: PRK07831 1138382001351 classical (c) SDRs; Region: SDR_c; cd05233 1138382001352 NAD(P) binding site [chemical binding]; other site 1138382001353 active site 1138382001354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001356 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1138382001357 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138382001358 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382001359 dimer interface [polypeptide binding]; other site 1138382001360 active site 1138382001361 Nitronate monooxygenase; Region: NMO; pfam03060 1138382001362 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382001363 FMN binding site [chemical binding]; other site 1138382001364 substrate binding site [chemical binding]; other site 1138382001365 putative catalytic residue [active] 1138382001366 Coenzyme A transferase; Region: CoA_trans; cl17247 1138382001367 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138382001368 enoyl-CoA hydratase; Provisional; Region: PRK06495 1138382001369 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382001370 substrate binding site [chemical binding]; other site 1138382001371 oxyanion hole (OAH) forming residues; other site 1138382001372 trimer interface [polypeptide binding]; other site 1138382001373 short chain dehydrogenase; Provisional; Region: PRK07856 1138382001374 classical (c) SDRs; Region: SDR_c; cd05233 1138382001375 NAD(P) binding site [chemical binding]; other site 1138382001376 active site 1138382001377 short chain dehydrogenase; Provisional; Region: PRK07791 1138382001378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001379 NAD(P) binding site [chemical binding]; other site 1138382001380 active site 1138382001381 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382001382 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382001383 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1138382001384 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382001385 dimer interface [polypeptide binding]; other site 1138382001386 active site 1138382001387 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001388 Cytochrome P450; Region: p450; cl12078 1138382001389 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001390 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382001391 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001392 active site 1138382001393 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001395 active site 1138382001396 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138382001397 active site 1138382001398 catalytic site [active] 1138382001399 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382001400 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382001401 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138382001402 putative active site [active] 1138382001403 putative catalytic site [active] 1138382001404 lipid-transfer protein; Provisional; Region: PRK07855 1138382001405 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382001406 active site 1138382001407 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138382001408 enoyl-CoA hydratase; Region: PLN02864 1138382001409 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1138382001410 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138382001411 dimer interaction site [polypeptide binding]; other site 1138382001412 substrate-binding tunnel; other site 1138382001413 active site 1138382001414 catalytic site [active] 1138382001415 substrate binding site [chemical binding]; other site 1138382001416 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1138382001417 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138382001418 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1138382001419 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1138382001420 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138382001421 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1138382001422 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1138382001423 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1138382001424 active site 1138382001425 catalytic residues [active] 1138382001426 metal binding site [ion binding]; metal-binding site 1138382001427 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1138382001428 short chain dehydrogenase; Provisional; Region: PRK07890 1138382001429 classical (c) SDRs; Region: SDR_c; cd05233 1138382001430 NAD(P) binding site [chemical binding]; other site 1138382001431 active site 1138382001432 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1138382001433 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138382001434 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382001435 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1138382001436 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1138382001437 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1138382001438 trimer interface [polypeptide binding]; other site 1138382001439 putative metal binding site [ion binding]; other site 1138382001440 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382001441 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1138382001442 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382001443 active site 1138382001444 lipid-transfer protein; Provisional; Region: PRK07937 1138382001445 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382001446 active site 1138382001447 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382001448 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382001449 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382001450 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382001451 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138382001452 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001453 Cytochrome P450; Region: p450; cl12078 1138382001454 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138382001455 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138382001456 putative active site [active] 1138382001457 enoyl-CoA hydratase; Provisional; Region: PRK07799 1138382001458 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382001459 substrate binding site [chemical binding]; other site 1138382001460 oxyanion hole (OAH) forming residues; other site 1138382001461 trimer interface [polypeptide binding]; other site 1138382001462 acyl-CoA synthetase; Validated; Region: PRK07798 1138382001463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382001464 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138382001465 acyl-activating enzyme (AAE) consensus motif; other site 1138382001466 acyl-activating enzyme (AAE) consensus motif; other site 1138382001467 putative AMP binding site [chemical binding]; other site 1138382001468 putative active site [active] 1138382001469 putative CoA binding site [chemical binding]; other site 1138382001470 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1138382001471 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382001472 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1138382001473 hypothetical protein; Validated; Region: PRK07586 1138382001474 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138382001475 PYR/PP interface [polypeptide binding]; other site 1138382001476 dimer interface [polypeptide binding]; other site 1138382001477 TPP binding site [chemical binding]; other site 1138382001478 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1138382001479 TPP-binding site [chemical binding]; other site 1138382001480 dimer interface [polypeptide binding]; other site 1138382001481 acyl-CoA synthetase; Validated; Region: PRK07867 1138382001482 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138382001483 acyl-activating enzyme (AAE) consensus motif; other site 1138382001484 putative AMP binding site [chemical binding]; other site 1138382001485 putative active site [active] 1138382001486 putative CoA binding site [chemical binding]; other site 1138382001487 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001488 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382001489 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382001490 active site 1138382001491 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001492 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138382001493 FAD binding site [chemical binding]; other site 1138382001494 substrate binding site [chemical binding]; other site 1138382001495 catalytic base [active] 1138382001496 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1138382001497 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1138382001498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001499 NAD(P) binding site [chemical binding]; other site 1138382001500 active site 1138382001501 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382001502 Permease; Region: Permease; pfam02405 1138382001503 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382001504 Permease; Region: Permease; pfam02405 1138382001505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382001506 mce related protein; Region: MCE; pfam02470 1138382001507 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382001508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382001509 mce related protein; Region: MCE; pfam02470 1138382001510 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382001511 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382001512 mce related protein; Region: MCE; pfam02470 1138382001513 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1138382001514 mce related protein; Region: MCE; pfam02470 1138382001515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382001516 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382001517 mce related protein; Region: MCE; pfam02470 1138382001518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382001519 mce related protein; Region: MCE; pfam02470 1138382001520 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1138382001521 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1138382001522 active site 1138382001523 homotetramer interface [polypeptide binding]; other site 1138382001524 enoyl-CoA hydratase; Provisional; Region: PRK08290 1138382001525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382001526 substrate binding site [chemical binding]; other site 1138382001527 oxyanion hole (OAH) forming residues; other site 1138382001528 trimer interface [polypeptide binding]; other site 1138382001529 short chain dehydrogenase; Provisional; Region: PRK05875 1138382001530 classical (c) SDRs; Region: SDR_c; cd05233 1138382001531 NAD(P) binding site [chemical binding]; other site 1138382001532 active site 1138382001533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382001534 classical (c) SDRs; Region: SDR_c; cd05233 1138382001535 NAD(P) binding site [chemical binding]; other site 1138382001536 active site 1138382001537 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138382001538 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138382001539 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138382001540 Amidase; Region: Amidase; cl11426 1138382001541 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382001542 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138382001543 Peptidase family S64; Region: Peptidase_S64; pfam08192 1138382001544 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138382001545 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138382001546 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138382001547 catalytic residue [active] 1138382001548 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382001549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382001550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382001551 active site 1138382001552 phosphorylation site [posttranslational modification] 1138382001553 intermolecular recognition site; other site 1138382001554 dimerization interface [polypeptide binding]; other site 1138382001555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382001556 DNA binding site [nucleotide binding] 1138382001557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382001558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138382001559 dimerization interface [polypeptide binding]; other site 1138382001560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382001561 dimer interface [polypeptide binding]; other site 1138382001562 phosphorylation site [posttranslational modification] 1138382001563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382001564 ATP binding site [chemical binding]; other site 1138382001565 Mg2+ binding site [ion binding]; other site 1138382001566 G-X-G motif; other site 1138382001567 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1138382001568 nucleotide binding site/active site [active] 1138382001569 HIT family signature motif; other site 1138382001570 catalytic residue [active] 1138382001571 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138382001572 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382001573 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382001574 NAD binding site [chemical binding]; other site 1138382001575 catalytic Zn binding site [ion binding]; other site 1138382001576 substrate binding site [chemical binding]; other site 1138382001577 structural Zn binding site [ion binding]; other site 1138382001578 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138382001579 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138382001580 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001581 Cytochrome P450; Region: p450; cl12078 1138382001582 short chain dehydrogenase; Provisional; Region: PRK07775 1138382001583 classical (c) SDRs; Region: SDR_c; cd05233 1138382001584 NAD(P) binding site [chemical binding]; other site 1138382001585 active site 1138382001586 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001587 Cytochrome P450; Region: p450; cl12078 1138382001588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001589 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138382001590 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138382001591 NAD binding site [chemical binding]; other site 1138382001592 catalytic residues [active] 1138382001593 short chain dehydrogenase; Provisional; Region: PRK07774 1138382001594 classical (c) SDRs; Region: SDR_c; cd05233 1138382001595 NAD(P) binding site [chemical binding]; other site 1138382001596 active site 1138382001597 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138382001598 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138382001599 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1138382001600 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138382001601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382001602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382001603 active site 1138382001604 catalytic tetrad [active] 1138382001605 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382001606 MarR family; Region: MarR; pfam01047 1138382001607 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1138382001608 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1138382001609 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1138382001610 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1138382001611 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1138382001612 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1138382001613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138382001614 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1138382001615 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1138382001616 adenylosuccinate lyase; Region: purB; TIGR00928 1138382001617 tetramer interface [polypeptide binding]; other site 1138382001618 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001619 Cytochrome P450; Region: p450; cl12078 1138382001620 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1138382001621 gating phenylalanine in ion channel; other site 1138382001622 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1138382001623 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1138382001624 ATP binding site [chemical binding]; other site 1138382001625 active site 1138382001626 substrate binding site [chemical binding]; other site 1138382001627 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1138382001628 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382001629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138382001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382001631 putative substrate translocation pore; other site 1138382001632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382001633 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138382001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382001635 putative substrate translocation pore; other site 1138382001636 Predicted deacetylase [General function prediction only]; Region: COG3233 1138382001637 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1138382001638 putative active site [active] 1138382001639 putative Zn binding site [ion binding]; other site 1138382001640 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138382001641 FAD binding domain; Region: FAD_binding_2; pfam00890 1138382001642 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138382001643 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1138382001644 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1138382001645 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1138382001646 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1138382001647 putative active site [active] 1138382001648 catalytic triad [active] 1138382001649 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382001650 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382001651 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138382001652 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138382001653 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382001654 putative acyl-acceptor binding pocket; other site 1138382001655 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382001656 extended (e) SDRs; Region: SDR_e; cd08946 1138382001657 NAD(P) binding site [chemical binding]; other site 1138382001658 active site 1138382001659 substrate binding site [chemical binding]; other site 1138382001660 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1138382001661 Cupin domain; Region: Cupin_2; cl17218 1138382001662 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1138382001663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382001664 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138382001665 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1138382001666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382001667 motif II; other site 1138382001668 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1138382001669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1138382001670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382001671 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138382001672 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138382001673 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1138382001674 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138382001675 putative NAD(P) binding site [chemical binding]; other site 1138382001676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001679 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382001680 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382001681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1138382001682 MOSC domain; Region: MOSC; pfam03473 1138382001683 3-alpha domain; Region: 3-alpha; pfam03475 1138382001684 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1138382001685 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138382001686 FAD binding pocket [chemical binding]; other site 1138382001687 FAD binding motif [chemical binding]; other site 1138382001688 phosphate binding motif [ion binding]; other site 1138382001689 beta-alpha-beta structure motif; other site 1138382001690 NAD binding pocket [chemical binding]; other site 1138382001691 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1138382001692 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1138382001693 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1138382001694 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1138382001695 active site 1138382001696 metal binding site [ion binding]; metal-binding site 1138382001697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001699 Ecdysteroid kinase; Region: EcKinase; cl17738 1138382001700 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382001701 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1138382001702 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1138382001703 dimerization interface [polypeptide binding]; other site 1138382001704 ATP binding site [chemical binding]; other site 1138382001705 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1138382001706 dimerization interface [polypeptide binding]; other site 1138382001707 ATP binding site [chemical binding]; other site 1138382001708 CAAX protease self-immunity; Region: Abi; pfam02517 1138382001709 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382001710 mce related protein; Region: MCE; pfam02470 1138382001711 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382001712 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1138382001713 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1138382001714 active site 1138382001715 tetramer interface [polypeptide binding]; other site 1138382001716 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382001717 active site 1138382001718 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1138382001719 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1138382001720 dimerization interface [polypeptide binding]; other site 1138382001721 putative ATP binding site [chemical binding]; other site 1138382001722 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1138382001723 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1138382001724 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1138382001725 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1138382001726 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1138382001727 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1138382001728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382001729 catalytic residue [active] 1138382001730 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138382001731 heme-binding site [chemical binding]; other site 1138382001732 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1138382001733 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138382001734 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138382001735 active site residue [active] 1138382001736 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138382001737 active site residue [active] 1138382001738 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1138382001739 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138382001740 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138382001741 catalytic residues [active] 1138382001742 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138382001743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382001744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382001745 DNA binding site [nucleotide binding] 1138382001746 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1138382001747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382001748 Coenzyme A binding pocket [chemical binding]; other site 1138382001749 PBP superfamily domain; Region: PBP_like_2; cl17296 1138382001750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382001751 dimer interface [polypeptide binding]; other site 1138382001752 conserved gate region; other site 1138382001753 putative PBP binding loops; other site 1138382001754 ABC-ATPase subunit interface; other site 1138382001755 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1138382001756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382001757 dimer interface [polypeptide binding]; other site 1138382001758 conserved gate region; other site 1138382001759 putative PBP binding loops; other site 1138382001760 ABC-ATPase subunit interface; other site 1138382001761 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1138382001762 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138382001763 Walker A/P-loop; other site 1138382001764 ATP binding site [chemical binding]; other site 1138382001765 Q-loop/lid; other site 1138382001766 ABC transporter signature motif; other site 1138382001767 Walker B; other site 1138382001768 D-loop; other site 1138382001769 H-loop/switch region; other site 1138382001770 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1138382001771 PhoU domain; Region: PhoU; pfam01895 1138382001772 PhoU domain; Region: PhoU; pfam01895 1138382001773 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1138382001774 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138382001775 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1138382001776 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1138382001777 FMN binding site [chemical binding]; other site 1138382001778 active site 1138382001779 catalytic residues [active] 1138382001780 substrate binding site [chemical binding]; other site 1138382001781 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1138382001782 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1138382001783 homodimer interface [polypeptide binding]; other site 1138382001784 putative substrate binding pocket [chemical binding]; other site 1138382001785 diiron center [ion binding]; other site 1138382001786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138382001788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382001789 dimerization interface [polypeptide binding]; other site 1138382001790 putative DNA binding site [nucleotide binding]; other site 1138382001791 putative Zn2+ binding site [ion binding]; other site 1138382001792 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138382001793 nucleoside/Zn binding site; other site 1138382001794 dimer interface [polypeptide binding]; other site 1138382001795 catalytic motif [active] 1138382001796 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382001797 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382001798 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1138382001799 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138382001800 active site 1138382001801 DNA binding site [nucleotide binding] 1138382001802 Int/Topo IB signature motif; other site 1138382001803 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1138382001804 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138382001805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382001806 DNA-binding site [nucleotide binding]; DNA binding site 1138382001807 UTRA domain; Region: UTRA; pfam07702 1138382001808 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382001809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001812 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382001813 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382001814 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138382001815 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1138382001816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001818 Cytochrome P450; Region: p450; cl12078 1138382001819 Integrase core domain; Region: rve; pfam00665 1138382001820 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001821 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1138382001822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001823 potential frameshift: common BLAST hit: gi|118463161|ref|YP_880115.1| carveol dehydrogenase 1138382001824 classical (c) SDRs; Region: SDR_c; cd05233 1138382001825 NAD(P) binding site [chemical binding]; other site 1138382001826 active site 1138382001827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001830 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001831 Cytochrome P450; Region: p450; cl12078 1138382001832 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1138382001833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382001834 DNA-binding site [nucleotide binding]; DNA binding site 1138382001835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382001836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382001837 homodimer interface [polypeptide binding]; other site 1138382001838 catalytic residue [active] 1138382001839 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138382001840 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382001841 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1138382001842 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382001843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382001844 S-adenosylmethionine binding site [chemical binding]; other site 1138382001845 short chain dehydrogenase; Provisional; Region: PRK07890 1138382001846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001847 NAD(P) binding site [chemical binding]; other site 1138382001848 active site 1138382001849 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1138382001850 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1138382001851 B12 binding site [chemical binding]; other site 1138382001852 cobalt ligand [ion binding]; other site 1138382001853 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138382001854 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382001855 putative CoA-transferase; Provisional; Region: PRK11430 1138382001856 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382001857 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138382001858 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138382001859 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382001860 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382001861 catalytic loop [active] 1138382001862 iron binding site [ion binding]; other site 1138382001863 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382001864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382001865 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382001866 acyl-activating enzyme (AAE) consensus motif; other site 1138382001867 acyl-activating enzyme (AAE) consensus motif; other site 1138382001868 AMP binding site [chemical binding]; other site 1138382001869 active site 1138382001870 CoA binding site [chemical binding]; other site 1138382001871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001872 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382001874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382001875 active site 1138382001876 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382001877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382001878 substrate binding site [chemical binding]; other site 1138382001879 oxyanion hole (OAH) forming residues; other site 1138382001880 trimer interface [polypeptide binding]; other site 1138382001881 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1138382001882 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1138382001883 putative acyltransferase; Provisional; Region: PRK05790 1138382001884 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382001885 dimer interface [polypeptide binding]; other site 1138382001886 active site 1138382001887 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 1138382001888 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1138382001889 Walker A; other site 1138382001890 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1138382001891 G4 box; other site 1138382001892 G5 box; other site 1138382001893 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1138382001894 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1138382001895 TPP-binding site [chemical binding]; other site 1138382001896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382001897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382001898 active site 1138382001899 phosphorylation site [posttranslational modification] 1138382001900 intermolecular recognition site; other site 1138382001901 dimerization interface [polypeptide binding]; other site 1138382001902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382001903 DNA binding residues [nucleotide binding] 1138382001904 dimerization interface [polypeptide binding]; other site 1138382001905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138382001906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382001907 ATP binding site [chemical binding]; other site 1138382001908 Mg2+ binding site [ion binding]; other site 1138382001909 G-X-G motif; other site 1138382001910 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138382001911 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1138382001912 conserved cys residue [active] 1138382001913 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1138382001914 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1138382001915 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382001916 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138382001917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382001918 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382001919 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1138382001920 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382001921 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 1138382001922 active site 1138382001923 metal binding site [ion binding]; metal-binding site 1138382001924 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1138382001925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382001926 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1138382001927 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138382001928 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382001929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001930 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382001931 NAD(P) binding site [chemical binding]; other site 1138382001932 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1138382001933 active site 1138382001934 Putative cyclase; Region: Cyclase; pfam04199 1138382001935 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382001936 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138382001937 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138382001938 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138382001939 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138382001940 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138382001941 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138382001942 short chain dehydrogenase; Provisional; Region: PRK06500 1138382001943 classical (c) SDRs; Region: SDR_c; cd05233 1138382001944 NAD(P) binding site [chemical binding]; other site 1138382001945 active site 1138382001946 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138382001947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001948 NAD(P) binding site [chemical binding]; other site 1138382001949 active site 1138382001950 AAA ATPase domain; Region: AAA_16; pfam13191 1138382001951 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382001952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382001953 DNA binding residues [nucleotide binding] 1138382001954 dimerization interface [polypeptide binding]; other site 1138382001955 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138382001956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001957 NAD(P) binding site [chemical binding]; other site 1138382001958 active site 1138382001959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138382001960 active site 1138382001961 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1138382001962 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1138382001963 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1138382001964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382001965 putative ADP-binding pocket [chemical binding]; other site 1138382001966 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138382001967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382001968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382001969 Cytochrome P450; Region: p450; cl12078 1138382001970 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382001971 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382001972 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138382001973 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138382001974 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138382001975 active site 1138382001976 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138382001977 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138382001978 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138382001979 active site 1138382001980 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138382001981 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382001982 substrate binding site [chemical binding]; other site 1138382001983 oxyanion hole (OAH) forming residues; other site 1138382001984 trimer interface [polypeptide binding]; other site 1138382001985 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382001986 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382001987 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382001988 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382001989 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138382001990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382001991 NAD(P) binding site [chemical binding]; other site 1138382001992 active site 1138382001993 short chain dehydrogenase; Provisional; Region: PRK05876 1138382001994 classical (c) SDRs; Region: SDR_c; cd05233 1138382001995 NAD(P) binding site [chemical binding]; other site 1138382001996 active site 1138382001997 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382001998 classical (c) SDRs; Region: SDR_c; cd05233 1138382001999 NAD(P) binding site [chemical binding]; other site 1138382002000 active site 1138382002001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002005 active site 1138382002006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002008 active site 1138382002009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002010 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002011 active site 1138382002012 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382002013 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138382002014 Amidohydrolase; Region: Amidohydro_4; pfam13147 1138382002015 active site 1138382002016 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382002017 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382002018 [2Fe-2S] cluster binding site [ion binding]; other site 1138382002019 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138382002020 alpha subunit interface [polypeptide binding]; other site 1138382002021 active site 1138382002022 substrate binding site [chemical binding]; other site 1138382002023 Fe binding site [ion binding]; other site 1138382002024 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382002025 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382002026 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382002027 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002028 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002029 active site 1138382002030 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138382002031 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002032 substrate binding site [chemical binding]; other site 1138382002033 oxyanion hole (OAH) forming residues; other site 1138382002034 trimer interface [polypeptide binding]; other site 1138382002035 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138382002036 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382002037 dimer interface [polypeptide binding]; other site 1138382002038 active site 1138382002039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002040 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382002041 Cytochrome P450; Region: p450; cl12078 1138382002042 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138382002043 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1138382002044 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138382002045 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138382002046 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382002047 Cytochrome P450; Region: p450; cl12078 1138382002048 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138382002049 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138382002050 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138382002051 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138382002052 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382002053 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382002054 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382002055 lipid-transfer protein; Provisional; Region: PRK07855 1138382002056 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382002057 active site 1138382002058 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382002059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382002060 NAD(P) binding site [chemical binding]; other site 1138382002061 active site 1138382002062 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138382002063 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382002064 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382002065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002067 active site 1138382002068 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138382002069 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1138382002070 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382002071 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1138382002072 iron-sulfur cluster [ion binding]; other site 1138382002073 [2Fe-2S] cluster binding site [ion binding]; other site 1138382002074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382002075 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382002076 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138382002077 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138382002078 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138382002079 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138382002080 FMN binding site [chemical binding]; other site 1138382002081 dimer interface [polypeptide binding]; other site 1138382002082 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138382002083 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382002084 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002085 active site 1138382002086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002087 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002088 active site 1138382002089 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138382002090 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138382002091 Integrase core domain; Region: rve; pfam00665 1138382002092 putative transposase OrfB; Reviewed; Region: PHA02517 1138382002093 HTH-like domain; Region: HTH_21; pfam13276 1138382002094 Integrase core domain; Region: rve; pfam00665 1138382002095 Integrase core domain; Region: rve_3; pfam13683 1138382002096 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382002097 Cytochrome P450; Region: p450; cl12078 1138382002098 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1138382002099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382002100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382002101 NAD(P) binding site [chemical binding]; other site 1138382002102 active site 1138382002103 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138382002104 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138382002105 NAD binding site [chemical binding]; other site 1138382002106 catalytic residues [active] 1138382002107 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382002108 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382002109 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382002110 Permease; Region: Permease; pfam02405 1138382002111 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382002112 Permease; Region: Permease; pfam02405 1138382002113 mce related protein; Region: MCE; pfam02470 1138382002114 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382002115 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382002116 mce related protein; Region: MCE; pfam02470 1138382002117 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382002118 mce related protein; Region: MCE; pfam02470 1138382002119 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382002120 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382002121 mce related protein; Region: MCE; pfam02470 1138382002122 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382002123 mce related protein; Region: MCE; pfam02470 1138382002124 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382002125 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382002126 mce related protein; Region: MCE; pfam02470 1138382002127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002129 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1138382002130 Subunit I/III interface [polypeptide binding]; other site 1138382002131 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382002132 Cytochrome P450; Region: p450; cl12078 1138382002133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002135 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138382002136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002137 substrate binding site [chemical binding]; other site 1138382002138 oxyanion hole (OAH) forming residues; other site 1138382002139 trimer interface [polypeptide binding]; other site 1138382002140 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138382002141 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382002142 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1138382002143 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382002144 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138382002145 acyl-activating enzyme (AAE) consensus motif; other site 1138382002146 acyl-activating enzyme (AAE) consensus motif; other site 1138382002147 putative AMP binding site [chemical binding]; other site 1138382002148 putative active site [active] 1138382002149 putative CoA binding site [chemical binding]; other site 1138382002150 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1138382002151 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1138382002152 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1138382002153 dimer interface [polypeptide binding]; other site 1138382002154 PYR/PP interface [polypeptide binding]; other site 1138382002155 TPP binding site [chemical binding]; other site 1138382002156 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382002157 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1138382002158 TPP-binding site [chemical binding]; other site 1138382002159 dimer interface [polypeptide binding]; other site 1138382002160 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138382002161 putative hydrophobic ligand binding site [chemical binding]; other site 1138382002162 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382002163 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382002164 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138382002165 putative hydrophobic ligand binding site [chemical binding]; other site 1138382002166 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138382002167 putative hydrophobic ligand binding site [chemical binding]; other site 1138382002168 aminotransferase; Validated; Region: PRK07777 1138382002169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382002170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382002171 homodimer interface [polypeptide binding]; other site 1138382002172 catalytic residue [active] 1138382002173 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1138382002174 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382002175 dimer interface [polypeptide binding]; other site 1138382002176 active site 1138382002177 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382002178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002179 substrate binding site [chemical binding]; other site 1138382002180 oxyanion hole (OAH) forming residues; other site 1138382002181 trimer interface [polypeptide binding]; other site 1138382002182 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1138382002183 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138382002184 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138382002185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382002186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382002187 S-adenosylmethionine binding site [chemical binding]; other site 1138382002188 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138382002189 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138382002190 hypothetical protein; Provisional; Region: PRK07588 1138382002191 hypothetical protein; Provisional; Region: PRK07236 1138382002192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002194 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382002195 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138382002196 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1138382002197 Cupin; Region: Cupin_6; pfam12852 1138382002198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138382002199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382002200 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1138382002201 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382002202 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382002203 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138382002204 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382002205 active site 1138382002206 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138382002207 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138382002208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138382002209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382002210 ATP binding site [chemical binding]; other site 1138382002211 putative Mg++ binding site [ion binding]; other site 1138382002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382002213 nucleotide binding region [chemical binding]; other site 1138382002214 ATP-binding site [chemical binding]; other site 1138382002215 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138382002216 WYL domain; Region: WYL; pfam13280 1138382002217 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1138382002218 trimer interface [polypeptide binding]; other site 1138382002219 dimer interface [polypeptide binding]; other site 1138382002220 putative active site [active] 1138382002221 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138382002222 MPT binding site; other site 1138382002223 trimer interface [polypeptide binding]; other site 1138382002224 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1138382002225 MoaE homodimer interface [polypeptide binding]; other site 1138382002226 MoaD interaction [polypeptide binding]; other site 1138382002227 active site residues [active] 1138382002228 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138382002229 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1138382002230 MoaE interaction surface [polypeptide binding]; other site 1138382002231 MoeB interaction surface [polypeptide binding]; other site 1138382002232 thiocarboxylated glycine; other site 1138382002233 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1138382002234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382002235 FeS/SAM binding site; other site 1138382002236 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1138382002237 hypothetical protein; Provisional; Region: PRK11770 1138382002238 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138382002239 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138382002240 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138382002241 DNA-binding site [nucleotide binding]; DNA binding site 1138382002242 RNA-binding motif; other site 1138382002243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002245 active site 1138382002246 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1138382002247 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138382002248 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1138382002249 putative dimer interface [polypeptide binding]; other site 1138382002250 N-terminal domain interface [polypeptide binding]; other site 1138382002251 putative substrate binding pocket (H-site) [chemical binding]; other site 1138382002252 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138382002253 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1138382002254 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138382002255 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1138382002256 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382002257 hydrophobic ligand binding site; other site 1138382002258 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382002259 MarR family; Region: MarR; pfam01047 1138382002260 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138382002261 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138382002262 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1138382002263 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1138382002264 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382002265 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382002266 catalytic residue [active] 1138382002267 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1138382002268 Ferredoxin [Energy production and conversion]; Region: COG1146 1138382002269 4Fe-4S binding domain; Region: Fer4; pfam00037 1138382002270 ferredoxin-NADP+ reductase; Region: PLN02852 1138382002271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382002272 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382002273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382002274 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382002275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1138382002276 putative dimer interface [polypeptide binding]; other site 1138382002277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382002278 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1138382002279 dimer interface [polypeptide binding]; other site 1138382002280 Citrate synthase; Region: Citrate_synt; pfam00285 1138382002281 active site 1138382002282 citrylCoA binding site [chemical binding]; other site 1138382002283 oxalacetate/citrate binding site [chemical binding]; other site 1138382002284 coenzyme A binding site [chemical binding]; other site 1138382002285 catalytic triad [active] 1138382002286 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1138382002287 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138382002288 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1138382002289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1138382002290 active site 1138382002291 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1138382002292 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1138382002293 dimer interface [polypeptide binding]; other site 1138382002294 active site 1138382002295 citrylCoA binding site [chemical binding]; other site 1138382002296 NADH binding [chemical binding]; other site 1138382002297 cationic pore residues; other site 1138382002298 oxalacetate/citrate binding site [chemical binding]; other site 1138382002299 coenzyme A binding site [chemical binding]; other site 1138382002300 catalytic triad [active] 1138382002301 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138382002302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382002303 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1138382002304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382002305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382002306 dimer interface [polypeptide binding]; other site 1138382002307 phosphorylation site [posttranslational modification] 1138382002308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382002309 ATP binding site [chemical binding]; other site 1138382002310 Mg2+ binding site [ion binding]; other site 1138382002311 G-X-G motif; other site 1138382002312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382002313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382002314 active site 1138382002315 phosphorylation site [posttranslational modification] 1138382002316 intermolecular recognition site; other site 1138382002317 dimerization interface [polypeptide binding]; other site 1138382002318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382002319 DNA binding site [nucleotide binding] 1138382002320 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138382002321 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1138382002322 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382002323 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382002324 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002325 substrate binding site [chemical binding]; other site 1138382002326 oxyanion hole (OAH) forming residues; other site 1138382002327 trimer interface [polypeptide binding]; other site 1138382002328 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138382002329 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138382002330 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382002331 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382002332 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1138382002333 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1138382002334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138382002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382002336 motif II; other site 1138382002337 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1138382002338 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382002339 hydrophobic ligand binding site; other site 1138382002340 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138382002341 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382002342 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138382002343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382002344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382002345 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382002346 active site 1138382002347 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138382002348 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138382002349 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1138382002350 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382002351 active site 1138382002352 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138382002353 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382002354 PPE family; Region: PPE; pfam00823 1138382002355 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382002356 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382002357 PPE family; Region: PPE; pfam00823 1138382002358 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1138382002359 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382002360 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138382002361 dimerization interface [polypeptide binding]; other site 1138382002362 putative catalytic residue [active] 1138382002363 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1138382002364 manganese transport protein MntH; Reviewed; Region: PRK00701 1138382002365 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138382002366 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382002367 short chain dehydrogenase; Provisional; Region: PRK07814 1138382002368 classical (c) SDRs; Region: SDR_c; cd05233 1138382002369 NAD(P) binding site [chemical binding]; other site 1138382002370 active site 1138382002371 PBP superfamily domain; Region: PBP_like_2; cl17296 1138382002372 PBP superfamily domain; Region: PBP_like_2; cl17296 1138382002373 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138382002374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382002375 dimer interface [polypeptide binding]; other site 1138382002376 conserved gate region; other site 1138382002377 putative PBP binding loops; other site 1138382002378 ABC-ATPase subunit interface; other site 1138382002379 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138382002380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382002381 dimer interface [polypeptide binding]; other site 1138382002382 conserved gate region; other site 1138382002383 putative PBP binding loops; other site 1138382002384 ABC-ATPase subunit interface; other site 1138382002385 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1138382002386 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1138382002387 putative DNA binding site [nucleotide binding]; other site 1138382002388 putative homodimer interface [polypeptide binding]; other site 1138382002389 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138382002390 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1138382002391 putative substrate binding site [chemical binding]; other site 1138382002392 putative ATP binding site [chemical binding]; other site 1138382002393 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1138382002394 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1138382002395 nucleotide binding site [chemical binding]; other site 1138382002396 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1138382002397 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1138382002398 active site 1138382002399 DNA binding site [nucleotide binding] 1138382002400 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1138382002401 DNA binding site [nucleotide binding] 1138382002402 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138382002403 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138382002404 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382002405 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382002406 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382002407 enoyl-CoA hydratase; Provisional; Region: PRK08260 1138382002408 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002409 substrate binding site [chemical binding]; other site 1138382002410 oxyanion hole (OAH) forming residues; other site 1138382002411 trimer interface [polypeptide binding]; other site 1138382002412 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382002413 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382002414 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382002415 anti sigma factor interaction site; other site 1138382002416 regulatory phosphorylation site [posttranslational modification]; other site 1138382002417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382002418 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382002419 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1138382002420 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1138382002421 active site 1138382002422 SAM binding site [chemical binding]; other site 1138382002423 homodimer interface [polypeptide binding]; other site 1138382002424 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138382002425 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1138382002426 putative DNA binding site [nucleotide binding]; other site 1138382002427 catalytic residue [active] 1138382002428 putative H2TH interface [polypeptide binding]; other site 1138382002429 putative catalytic residues [active] 1138382002430 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138382002431 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138382002432 short chain dehydrogenase; Provisional; Region: PRK08251 1138382002433 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1138382002434 putative NAD(P) binding site [chemical binding]; other site 1138382002435 active site 1138382002436 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1138382002437 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1138382002438 active site 1138382002439 dimer interface [polypeptide binding]; other site 1138382002440 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1138382002441 dimer interface [polypeptide binding]; other site 1138382002442 active site 1138382002443 Chorismate mutase type II; Region: CM_2; cl00693 1138382002444 potential frameshift: common BLAST hit: gi|118466048|ref|YP_880325.1| ATP-dependent DNA helicase PcrA 1138382002445 Part of AAA domain; Region: AAA_19; pfam13245 1138382002446 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1138382002447 Family description; Region: UvrD_C_2; pfam13538 1138382002448 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138382002449 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138382002450 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1138382002451 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1138382002452 CoA-ligase; Region: Ligase_CoA; pfam00549 1138382002453 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1138382002454 CoA binding domain; Region: CoA_binding; smart00881 1138382002455 CoA-ligase; Region: Ligase_CoA; pfam00549 1138382002456 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138382002457 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382002458 Omptin family; Region: Omptin; cl01886 1138382002459 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382002460 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382002461 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1138382002462 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1138382002463 active site 1138382002464 substrate binding site [chemical binding]; other site 1138382002465 cosubstrate binding site; other site 1138382002466 catalytic site [active] 1138382002467 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1138382002468 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1138382002469 purine monophosphate binding site [chemical binding]; other site 1138382002470 dimer interface [polypeptide binding]; other site 1138382002471 putative catalytic residues [active] 1138382002472 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1138382002473 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1138382002474 LGFP repeat; Region: LGFP; pfam08310 1138382002475 LGFP repeat; Region: LGFP; pfam08310 1138382002476 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1138382002477 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1138382002478 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1138382002479 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138382002480 metal ion-dependent adhesion site (MIDAS); other site 1138382002481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382002482 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382002483 active site 1138382002484 catalytic tetrad [active] 1138382002485 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138382002486 enoyl-CoA hydratase; Provisional; Region: PRK07827 1138382002487 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002488 substrate binding site [chemical binding]; other site 1138382002489 oxyanion hole (OAH) forming residues; other site 1138382002490 trimer interface [polypeptide binding]; other site 1138382002491 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002492 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382002493 active site 1138382002494 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138382002495 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382002496 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382002497 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138382002498 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138382002499 carboxyltransferase (CT) interaction site; other site 1138382002500 biotinylation site [posttranslational modification]; other site 1138382002501 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138382002502 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382002503 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382002504 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002505 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002506 active site 1138382002507 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1138382002508 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1138382002509 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382002510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382002511 active site 1138382002512 phosphorylation site [posttranslational modification] 1138382002513 intermolecular recognition site; other site 1138382002514 dimerization interface [polypeptide binding]; other site 1138382002515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382002516 DNA binding site [nucleotide binding] 1138382002517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382002518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138382002519 dimerization interface [polypeptide binding]; other site 1138382002520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382002521 dimer interface [polypeptide binding]; other site 1138382002522 phosphorylation site [posttranslational modification] 1138382002523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382002524 ATP binding site [chemical binding]; other site 1138382002525 Mg2+ binding site [ion binding]; other site 1138382002526 G-X-G motif; other site 1138382002527 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138382002528 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138382002529 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1138382002530 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138382002531 MPT binding site; other site 1138382002532 trimer interface [polypeptide binding]; other site 1138382002533 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1138382002534 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1138382002535 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1138382002536 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1138382002537 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1138382002538 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1138382002539 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1138382002540 active site 1138382002541 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138382002542 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138382002543 dimer interface [polypeptide binding]; other site 1138382002544 putative functional site; other site 1138382002545 putative MPT binding site; other site 1138382002546 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1138382002547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138382002548 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382002549 MarR family; Region: MarR_2; pfam12802 1138382002550 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1138382002551 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1138382002552 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382002553 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382002554 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1138382002555 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138382002556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382002557 DNA-binding site [nucleotide binding]; DNA binding site 1138382002558 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138382002559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382002560 Cytochrome P450; Region: p450; cl12078 1138382002561 Predicted acyl esterases [General function prediction only]; Region: COG2936 1138382002562 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138382002563 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1138382002564 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138382002565 metal binding site [ion binding]; metal-binding site 1138382002566 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1138382002567 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1138382002568 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1138382002569 dimer interface [polypeptide binding]; other site 1138382002570 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1138382002571 active site 1138382002572 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1138382002573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382002574 active site 1138382002575 motif I; other site 1138382002576 motif II; other site 1138382002577 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138382002578 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138382002579 ligand binding site [chemical binding]; other site 1138382002580 flexible hinge region; other site 1138382002581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138382002582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382002583 Coenzyme A binding pocket [chemical binding]; other site 1138382002584 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382002585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382002586 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1138382002587 Amidinotransferase; Region: Amidinotransf; cl12043 1138382002588 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1138382002589 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1138382002590 Predicted methyltransferases [General function prediction only]; Region: COG0313 1138382002591 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1138382002592 putative SAM binding site [chemical binding]; other site 1138382002593 putative homodimer interface [polypeptide binding]; other site 1138382002594 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1138382002595 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1138382002596 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1138382002597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382002598 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138382002599 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138382002600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382002601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382002602 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138382002603 GAF domain; Region: GAF; pfam01590 1138382002604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138382002605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138382002606 metal binding site [ion binding]; metal-binding site 1138382002607 active site 1138382002608 I-site; other site 1138382002609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138382002610 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138382002611 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1138382002612 Chain length determinant protein; Region: Wzz; pfam02706 1138382002613 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1138382002614 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382002615 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382002616 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382002617 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382002618 active site 1138382002619 catalytic tetrad [active] 1138382002620 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138382002621 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138382002622 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138382002623 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1138382002624 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1138382002625 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1138382002626 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1138382002627 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382002628 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138382002629 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1138382002630 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138382002631 active site 1138382002632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138382002633 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382002634 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382002635 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1138382002636 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1138382002637 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1138382002638 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1138382002639 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1138382002640 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382002641 PPE family; Region: PPE; pfam00823 1138382002642 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382002643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138382002648 PAS domain; Region: PAS_9; pfam13426 1138382002649 putative active site [active] 1138382002650 heme pocket [chemical binding]; other site 1138382002651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002652 WHG domain; Region: WHG; pfam13305 1138382002653 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1138382002654 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1138382002655 active site 1138382002656 HIGH motif; other site 1138382002657 KMSKS motif; other site 1138382002658 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1138382002659 tRNA binding surface [nucleotide binding]; other site 1138382002660 anticodon binding site; other site 1138382002661 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1138382002662 active site 1138382002663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1138382002664 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138382002665 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138382002666 G5 domain; Region: G5; pfam07501 1138382002667 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138382002668 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1138382002669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382002670 S-adenosylmethionine binding site [chemical binding]; other site 1138382002671 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1138382002672 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1138382002673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382002674 acyl-activating enzyme (AAE) consensus motif; other site 1138382002675 AMP binding site [chemical binding]; other site 1138382002676 active site 1138382002677 CoA binding site [chemical binding]; other site 1138382002678 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1138382002679 putative active site [active] 1138382002680 catalytic residue [active] 1138382002681 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1138382002682 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1138382002683 5S rRNA interface [nucleotide binding]; other site 1138382002684 CTC domain interface [polypeptide binding]; other site 1138382002685 L16 interface [polypeptide binding]; other site 1138382002686 short chain dehydrogenase; Provisional; Region: PRK06197 1138382002687 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138382002688 putative NAD(P) binding site [chemical binding]; other site 1138382002689 active site 1138382002690 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382002691 Cytochrome P450; Region: p450; cl12078 1138382002692 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382002693 cyclase homology domain; Region: CHD; cd07302 1138382002694 nucleotidyl binding site; other site 1138382002695 metal binding site [ion binding]; metal-binding site 1138382002696 dimer interface [polypeptide binding]; other site 1138382002697 Predicted ATPase [General function prediction only]; Region: COG3903 1138382002698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382002699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382002700 DNA binding residues [nucleotide binding] 1138382002701 dimerization interface [polypeptide binding]; other site 1138382002702 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138382002703 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1138382002704 ArsC family; Region: ArsC; pfam03960 1138382002705 catalytic residues [active] 1138382002706 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1138382002707 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1138382002708 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382002709 active site 1138382002710 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1138382002711 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1138382002712 Substrate binding site; other site 1138382002713 Mg++ binding site; other site 1138382002714 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1138382002715 active site 1138382002716 substrate binding site [chemical binding]; other site 1138382002717 CoA binding site [chemical binding]; other site 1138382002718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002720 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1138382002721 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1138382002722 active site 1138382002723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138382002724 substrate binding site [chemical binding]; other site 1138382002725 catalytic residues [active] 1138382002726 dimer interface [polypeptide binding]; other site 1138382002727 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1138382002728 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1138382002729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382002730 ATP binding site [chemical binding]; other site 1138382002731 putative Mg++ binding site [ion binding]; other site 1138382002732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382002733 nucleotide binding region [chemical binding]; other site 1138382002734 ATP-binding site [chemical binding]; other site 1138382002735 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1138382002736 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1138382002737 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1138382002738 homodimer interface [polypeptide binding]; other site 1138382002739 metal binding site [ion binding]; metal-binding site 1138382002740 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138382002741 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138382002742 enolase; Provisional; Region: eno; PRK00077 1138382002743 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1138382002744 dimer interface [polypeptide binding]; other site 1138382002745 metal binding site [ion binding]; metal-binding site 1138382002746 substrate binding pocket [chemical binding]; other site 1138382002747 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1138382002748 Septum formation initiator; Region: DivIC; pfam04977 1138382002749 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1138382002750 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138382002751 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138382002752 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1138382002753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382002754 active site 1138382002755 phosphorylation site [posttranslational modification] 1138382002756 intermolecular recognition site; other site 1138382002757 dimerization interface [polypeptide binding]; other site 1138382002758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382002759 DNA binding site [nucleotide binding] 1138382002760 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1138382002761 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1138382002762 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1138382002763 Ligand Binding Site [chemical binding]; other site 1138382002764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382002765 dimer interface [polypeptide binding]; other site 1138382002766 phosphorylation site [posttranslational modification] 1138382002767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382002768 ATP binding site [chemical binding]; other site 1138382002769 Mg2+ binding site [ion binding]; other site 1138382002770 G-X-G motif; other site 1138382002771 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1138382002772 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1138382002773 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1138382002774 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138382002775 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138382002776 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1138382002777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382002778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382002779 dimer interface [polypeptide binding]; other site 1138382002780 phosphorylation site [posttranslational modification] 1138382002781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382002782 ATP binding site [chemical binding]; other site 1138382002783 Mg2+ binding site [ion binding]; other site 1138382002784 G-X-G motif; other site 1138382002785 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382002786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382002787 active site 1138382002788 phosphorylation site [posttranslational modification] 1138382002789 intermolecular recognition site; other site 1138382002790 dimerization interface [polypeptide binding]; other site 1138382002791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382002792 DNA binding site [nucleotide binding] 1138382002793 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138382002794 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138382002795 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382002796 PPE family; Region: PPE; pfam00823 1138382002797 PE family; Region: PE; pfam00934 1138382002798 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382002799 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382002800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382002801 S-adenosylmethionine binding site [chemical binding]; other site 1138382002802 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138382002803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138382002804 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138382002805 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138382002806 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1138382002807 dimer interface [polypeptide binding]; other site 1138382002808 acyl-activating enzyme (AAE) consensus motif; other site 1138382002809 putative active site [active] 1138382002810 AMP binding site [chemical binding]; other site 1138382002811 putative CoA binding site [chemical binding]; other site 1138382002812 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1138382002813 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138382002814 putative active site [active] 1138382002815 putative dimer interface [polypeptide binding]; other site 1138382002816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382002817 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382002818 active site 1138382002819 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138382002820 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382002821 classical (c) SDRs; Region: SDR_c; cd05233 1138382002822 NAD(P) binding site [chemical binding]; other site 1138382002823 active site 1138382002824 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382002825 Cytochrome P450; Region: p450; cl12078 1138382002826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002828 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382002829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382002830 active site 1138382002831 short chain dehydrogenase; Provisional; Region: PRK07814 1138382002832 classical (c) SDRs; Region: SDR_c; cd05233 1138382002833 NAD(P) binding site [chemical binding]; other site 1138382002834 active site 1138382002835 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382002836 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382002837 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138382002838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382002839 classical (c) SDRs; Region: SDR_c; cd05233 1138382002840 NAD(P) binding site [chemical binding]; other site 1138382002841 active site 1138382002842 Patatin-like phospholipase; Region: Patatin; pfam01734 1138382002843 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1138382002844 hypothetical protein; Provisional; Region: PRK10279 1138382002845 active site 1138382002846 nucleophile elbow; other site 1138382002847 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1138382002848 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1138382002849 active site residue [active] 1138382002850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382002851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382002852 Predicted membrane protein [Function unknown]; Region: COG4425 1138382002853 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1138382002854 enoyl-CoA hydratase; Provisional; Region: PRK05862 1138382002855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002856 substrate binding site [chemical binding]; other site 1138382002857 oxyanion hole (OAH) forming residues; other site 1138382002858 trimer interface [polypeptide binding]; other site 1138382002859 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1138382002860 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382002861 substrate binding site [chemical binding]; other site 1138382002862 oxyanion hole (OAH) forming residues; other site 1138382002863 trimer interface [polypeptide binding]; other site 1138382002864 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1138382002865 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1138382002866 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138382002867 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138382002868 Integrase core domain; Region: rve; pfam00665 1138382002869 putative transposase OrfB; Reviewed; Region: PHA02517 1138382002870 HTH-like domain; Region: HTH_21; pfam13276 1138382002871 Integrase core domain; Region: rve; pfam00665 1138382002872 Integrase core domain; Region: rve_3; pfam13683 1138382002873 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1138382002874 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382002875 dimer interface [polypeptide binding]; other site 1138382002876 active site 1138382002877 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1138382002878 active site 1138382002879 catalytic triad [active] 1138382002880 oxyanion hole [active] 1138382002881 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382002882 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382002883 substrate binding pocket [chemical binding]; other site 1138382002884 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1138382002885 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138382002886 dimer interface [polypeptide binding]; other site 1138382002887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382002888 catalytic residue [active] 1138382002889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1138382002890 RDD family; Region: RDD; pfam06271 1138382002891 cystathionine gamma-synthase; Provisional; Region: PRK07811 1138382002892 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138382002893 homodimer interface [polypeptide binding]; other site 1138382002894 substrate-cofactor binding pocket; other site 1138382002895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382002896 catalytic residue [active] 1138382002897 Homeodomain-like domain; Region: HTH_23; cl17451 1138382002898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1138382002899 Integrase core domain; Region: rve; pfam00665 1138382002900 Integrase core domain; Region: rve_3; pfam13683 1138382002901 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138382002902 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1138382002903 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138382002904 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1138382002905 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1138382002906 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1138382002907 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1138382002908 catalytic residues [active] 1138382002909 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382002910 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1138382002911 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1138382002912 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138382002913 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138382002914 catalytic residue [active] 1138382002915 putative FPP diphosphate binding site; other site 1138382002916 putative FPP binding hydrophobic cleft; other site 1138382002917 dimer interface [polypeptide binding]; other site 1138382002918 putative IPP diphosphate binding site; other site 1138382002919 pantothenate kinase; Provisional; Region: PRK05439 1138382002920 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1138382002921 ATP-binding site [chemical binding]; other site 1138382002922 CoA-binding site [chemical binding]; other site 1138382002923 Mg2+-binding site [ion binding]; other site 1138382002924 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1138382002925 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1138382002926 dimer interface [polypeptide binding]; other site 1138382002927 active site 1138382002928 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1138382002929 folate binding site [chemical binding]; other site 1138382002930 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1138382002931 dinuclear metal binding motif [ion binding]; other site 1138382002932 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1138382002933 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1138382002934 putative active site [active] 1138382002935 PhoH-like protein; Region: PhoH; pfam02562 1138382002936 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1138382002937 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1138382002938 NodB motif; other site 1138382002939 active site 1138382002940 catalytic site [active] 1138382002941 metal binding site [ion binding]; metal-binding site 1138382002942 HAMP domain; Region: HAMP; pfam00672 1138382002943 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138382002944 cyclase homology domain; Region: CHD; cd07302 1138382002945 nucleotidyl binding site; other site 1138382002946 metal binding site [ion binding]; metal-binding site 1138382002947 dimer interface [polypeptide binding]; other site 1138382002948 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1138382002949 Class II fumarases; Region: Fumarase_classII; cd01362 1138382002950 active site 1138382002951 tetramer interface [polypeptide binding]; other site 1138382002952 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1138382002953 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1138382002954 putative active site [active] 1138382002955 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1138382002956 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1138382002957 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138382002958 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138382002959 homodimer interface [polypeptide binding]; other site 1138382002960 active site 1138382002961 TDP-binding site; other site 1138382002962 acceptor substrate-binding pocket; other site 1138382002963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382002964 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382002965 acyl-activating enzyme (AAE) consensus motif; other site 1138382002966 AMP binding site [chemical binding]; other site 1138382002967 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382002968 Condensation domain; Region: Condensation; pfam00668 1138382002969 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382002970 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138382002971 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382002972 substrate binding pocket [chemical binding]; other site 1138382002973 catalytic triad [active] 1138382002974 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1138382002975 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1138382002976 putative NAD(P) binding site [chemical binding]; other site 1138382002977 active site 1138382002978 putative substrate binding site [chemical binding]; other site 1138382002979 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1138382002980 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1138382002981 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1138382002982 generic binding surface II; other site 1138382002983 generic binding surface I; other site 1138382002984 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1138382002985 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1138382002986 GTP-binding protein YchF; Reviewed; Region: PRK09601 1138382002987 YchF GTPase; Region: YchF; cd01900 1138382002988 G1 box; other site 1138382002989 GTP/Mg2+ binding site [chemical binding]; other site 1138382002990 Switch I region; other site 1138382002991 G2 box; other site 1138382002992 Switch II region; other site 1138382002993 G3 box; other site 1138382002994 G4 box; other site 1138382002995 G5 box; other site 1138382002996 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1138382002997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382002998 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1138382002999 putative active site [active] 1138382003000 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1138382003001 putative dimer interface [polypeptide binding]; other site 1138382003002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382003003 ligand binding site [chemical binding]; other site 1138382003004 Zn binding site [ion binding]; other site 1138382003005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382003006 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382003007 active site 1138382003008 metal binding site [ion binding]; metal-binding site 1138382003009 NlpC/P60 family; Region: NLPC_P60; cl17555 1138382003010 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138382003011 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382003012 cyclase homology domain; Region: CHD; cd07302 1138382003013 nucleotidyl binding site; other site 1138382003014 metal binding site [ion binding]; metal-binding site 1138382003015 dimer interface [polypeptide binding]; other site 1138382003016 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1138382003017 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138382003018 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138382003019 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1138382003020 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138382003021 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382003022 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382003023 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1138382003024 dimer interface [polypeptide binding]; other site 1138382003025 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382003026 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382003027 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1138382003028 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1138382003029 Predicted membrane protein [Function unknown]; Region: COG2259 1138382003030 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1138382003031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382003032 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1138382003033 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1138382003034 TrkA-C domain; Region: TrkA_C; pfam02080 1138382003035 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138382003036 TrkA-N domain; Region: TrkA_N; pfam02254 1138382003037 TrkA-C domain; Region: TrkA_C; pfam02080 1138382003038 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138382003039 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1138382003040 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1138382003041 THF binding site; other site 1138382003042 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1138382003043 substrate binding site [chemical binding]; other site 1138382003044 THF binding site; other site 1138382003045 zinc-binding site [ion binding]; other site 1138382003046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003047 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138382003048 NAD(P) binding site [chemical binding]; other site 1138382003049 active site 1138382003050 short chain dehydrogenase; Provisional; Region: PRK12829 1138382003051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003052 NAD(P) binding site [chemical binding]; other site 1138382003053 active site 1138382003054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003058 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138382003059 FMN binding site [chemical binding]; other site 1138382003060 dimer interface [polypeptide binding]; other site 1138382003061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003062 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382003063 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003064 active site 1138382003065 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003066 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138382003067 active site 1138382003068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003069 short chain dehydrogenase; Provisional; Region: PRK07791 1138382003070 NAD(P) binding site [chemical binding]; other site 1138382003071 active site 1138382003072 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138382003073 metal ion-dependent adhesion site (MIDAS); other site 1138382003074 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138382003075 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1138382003076 Walker A motif; other site 1138382003077 ATP binding site [chemical binding]; other site 1138382003078 Walker B motif; other site 1138382003079 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138382003080 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138382003081 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138382003082 ligand binding site [chemical binding]; other site 1138382003083 short chain dehydrogenase; Provisional; Region: PRK06179 1138382003084 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138382003085 NADP binding site [chemical binding]; other site 1138382003086 active site 1138382003087 steroid binding site; other site 1138382003088 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003089 Cytochrome P450; Region: p450; cl12078 1138382003090 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138382003091 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138382003092 NAD binding site [chemical binding]; other site 1138382003093 catalytic residues [active] 1138382003094 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138382003095 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382003096 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003097 Cytochrome P450; Region: p450; cl12078 1138382003098 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138382003099 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382003100 putative acyl-acceptor binding pocket; other site 1138382003101 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382003102 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382003103 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138382003104 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138382003105 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382003106 dimer interface [polypeptide binding]; other site 1138382003107 active site 1138382003108 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138382003109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003110 substrate binding site [chemical binding]; other site 1138382003111 oxyanion hole (OAH) forming residues; other site 1138382003112 trimer interface [polypeptide binding]; other site 1138382003113 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382003114 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1138382003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1138382003116 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138382003117 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138382003118 malonyl-CoA binding site [chemical binding]; other site 1138382003119 dimer interface [polypeptide binding]; other site 1138382003120 active site 1138382003121 product binding site; other site 1138382003122 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138382003123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003124 NAD(P) binding site [chemical binding]; other site 1138382003125 active site 1138382003126 CAAX protease self-immunity; Region: Abi; pfam02517 1138382003127 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1138382003128 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138382003129 putative NAD(P) binding site [chemical binding]; other site 1138382003130 putative active site [active] 1138382003131 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138382003132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003133 substrate binding site [chemical binding]; other site 1138382003134 oxyanion hole (OAH) forming residues; other site 1138382003135 trimer interface [polypeptide binding]; other site 1138382003136 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382003137 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382003138 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1138382003139 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1138382003140 NAD binding site [chemical binding]; other site 1138382003141 homodimer interface [polypeptide binding]; other site 1138382003142 homotetramer interface [polypeptide binding]; other site 1138382003143 active site 1138382003144 MMPL family; Region: MMPL; pfam03176 1138382003145 MMPL family; Region: MMPL; pfam03176 1138382003146 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382003147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382003148 S-adenosylmethionine binding site [chemical binding]; other site 1138382003149 NAD-dependent deacetylase; Provisional; Region: PRK00481 1138382003150 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1138382003151 NAD+ binding site [chemical binding]; other site 1138382003152 substrate binding site [chemical binding]; other site 1138382003153 Zn binding site [ion binding]; other site 1138382003154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382003155 DNA-binding site [nucleotide binding]; DNA binding site 1138382003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1138382003157 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382003158 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138382003159 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138382003160 minor groove reading motif; other site 1138382003161 mannosyltransferase; Provisional; Region: pimE; PRK13375 1138382003162 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1138382003163 aromatic arch; other site 1138382003164 DCoH dimer interaction site [polypeptide binding]; other site 1138382003165 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1138382003166 DCoH tetramer interaction site [polypeptide binding]; other site 1138382003167 substrate binding site [chemical binding]; other site 1138382003168 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1138382003169 active site 1138382003170 8-oxo-dGMP binding site [chemical binding]; other site 1138382003171 nudix motif; other site 1138382003172 metal binding site [ion binding]; metal-binding site 1138382003173 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1138382003174 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1138382003175 [4Fe-4S] binding site [ion binding]; other site 1138382003176 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382003177 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382003178 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382003179 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1138382003180 molybdopterin cofactor binding site; other site 1138382003181 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1138382003182 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1138382003183 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1138382003184 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1138382003185 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1138382003186 G1 box; other site 1138382003187 putative GEF interaction site [polypeptide binding]; other site 1138382003188 GTP/Mg2+ binding site [chemical binding]; other site 1138382003189 Switch I region; other site 1138382003190 G2 box; other site 1138382003191 G3 box; other site 1138382003192 Switch II region; other site 1138382003193 G4 box; other site 1138382003194 G5 box; other site 1138382003195 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1138382003196 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1138382003197 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138382003198 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138382003199 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138382003200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003202 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1138382003203 FO synthase; Reviewed; Region: fbiC; PRK09234 1138382003204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382003205 FeS/SAM binding site; other site 1138382003206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382003207 FeS/SAM binding site; other site 1138382003208 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1138382003209 4Fe-4S binding domain; Region: Fer4; pfam00037 1138382003210 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1138382003211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382003212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382003213 homodimer interface [polypeptide binding]; other site 1138382003214 catalytic residue [active] 1138382003215 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138382003216 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138382003217 generic binding surface II; other site 1138382003218 ssDNA binding site; other site 1138382003219 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382003220 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382003221 active site 1138382003222 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382003223 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138382003224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003225 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138382003226 Enoylreductase; Region: PKS_ER; smart00829 1138382003227 NAD(P) binding site [chemical binding]; other site 1138382003228 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138382003229 KR domain; Region: KR; pfam08659 1138382003230 putative NADP binding site [chemical binding]; other site 1138382003231 active site 1138382003232 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382003233 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382003234 PPE family; Region: PPE; pfam00823 1138382003235 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382003236 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382003237 PPE family; Region: PPE; pfam00823 1138382003238 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382003239 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138382003240 ligand-binding site [chemical binding]; other site 1138382003241 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1138382003242 ATP-sulfurylase; Region: ATPS; cd00517 1138382003243 active site 1138382003244 HXXH motif; other site 1138382003245 flexible loop; other site 1138382003246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138382003247 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138382003248 acyl-CoA synthetase; Validated; Region: PRK05850 1138382003249 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138382003250 acyl-activating enzyme (AAE) consensus motif; other site 1138382003251 active site 1138382003252 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382003253 PPE family; Region: PPE; pfam00823 1138382003254 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138382003255 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138382003256 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382003257 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1138382003258 NAD(P) binding site [chemical binding]; other site 1138382003259 catalytic residues [active] 1138382003260 Proline dehydrogenase; Region: Pro_dh; cl03282 1138382003261 putative transposase OrfB; Reviewed; Region: PHA02517 1138382003262 HTH-like domain; Region: HTH_21; pfam13276 1138382003263 Integrase core domain; Region: rve; pfam00665 1138382003264 Integrase core domain; Region: rve_3; pfam13683 1138382003265 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138382003266 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138382003267 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138382003268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003270 lipid-transfer protein; Provisional; Region: PRK07855 1138382003271 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003272 active site 1138382003273 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138382003274 putative active site [active] 1138382003275 putative catalytic site [active] 1138382003276 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382003277 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003278 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382003279 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382003280 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138382003281 NAD binding site [chemical binding]; other site 1138382003282 catalytic residues [active] 1138382003283 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382003284 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1138382003285 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382003286 acyl-CoA synthetase; Validated; Region: PRK07787 1138382003287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003288 acyl-activating enzyme (AAE) consensus motif; other site 1138382003289 AMP binding site [chemical binding]; other site 1138382003290 active site 1138382003291 CoA binding site [chemical binding]; other site 1138382003292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382003293 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138382003294 putative substrate translocation pore; other site 1138382003295 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1138382003296 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1138382003297 putative trimer interface [polypeptide binding]; other site 1138382003298 putative CoA binding site [chemical binding]; other site 1138382003299 PE family; Region: PE; pfam00934 1138382003300 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382003301 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382003302 PPE family; Region: PPE; pfam00823 1138382003303 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1138382003304 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1138382003305 metal binding site [ion binding]; metal-binding site 1138382003306 putative dimer interface [polypeptide binding]; other site 1138382003307 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1138382003308 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1138382003309 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138382003310 acyl-activating enzyme (AAE) consensus motif; other site 1138382003311 putative AMP binding site [chemical binding]; other site 1138382003312 putative active site [active] 1138382003313 putative CoA binding site [chemical binding]; other site 1138382003314 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1138382003315 dihydropteroate synthase; Region: DHPS; TIGR01496 1138382003316 substrate binding pocket [chemical binding]; other site 1138382003317 dimer interface [polypeptide binding]; other site 1138382003318 inhibitor binding site; inhibition site 1138382003319 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1138382003320 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138382003321 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138382003322 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1138382003323 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1138382003324 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1138382003325 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382003326 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1138382003327 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1138382003328 ligand binding site; other site 1138382003329 oligomer interface; other site 1138382003330 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1138382003331 dimer interface [polypeptide binding]; other site 1138382003332 N-terminal domain interface [polypeptide binding]; other site 1138382003333 sulfate 1 binding site; other site 1138382003334 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138382003335 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1138382003336 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138382003337 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138382003338 Walker A/P-loop; other site 1138382003339 ATP binding site [chemical binding]; other site 1138382003340 Q-loop/lid; other site 1138382003341 ABC transporter signature motif; other site 1138382003342 Walker B; other site 1138382003343 D-loop; other site 1138382003344 H-loop/switch region; other site 1138382003345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003347 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138382003348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382003349 S-adenosylmethionine binding site [chemical binding]; other site 1138382003350 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1138382003351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382003352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382003353 DNA binding residues [nucleotide binding] 1138382003354 Putative zinc-finger; Region: zf-HC2; pfam13490 1138382003355 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138382003356 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138382003357 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138382003358 protein binding site [polypeptide binding]; other site 1138382003359 sec-independent translocase; Provisional; Region: PRK03100 1138382003360 Domain of unknown function DUF59; Region: DUF59; cl00941 1138382003361 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1138382003362 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1138382003363 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1138382003364 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138382003365 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138382003366 catalytic residue [active] 1138382003367 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1138382003368 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1138382003369 MgtE intracellular N domain; Region: MgtE_N; smart00924 1138382003370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1138382003371 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138382003372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138382003373 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138382003374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382003375 dimer interface [polypeptide binding]; other site 1138382003376 conserved gate region; other site 1138382003377 putative PBP binding loops; other site 1138382003378 ABC-ATPase subunit interface; other site 1138382003379 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138382003380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382003381 dimer interface [polypeptide binding]; other site 1138382003382 conserved gate region; other site 1138382003383 ABC-ATPase subunit interface; other site 1138382003384 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138382003385 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138382003386 Walker A/P-loop; other site 1138382003387 ATP binding site [chemical binding]; other site 1138382003388 Q-loop/lid; other site 1138382003389 ABC transporter signature motif; other site 1138382003390 Walker B; other site 1138382003391 D-loop; other site 1138382003392 H-loop/switch region; other site 1138382003393 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1138382003394 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1138382003395 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1138382003396 oligomer interface [polypeptide binding]; other site 1138382003397 metal binding site [ion binding]; metal-binding site 1138382003398 metal binding site [ion binding]; metal-binding site 1138382003399 putative Cl binding site [ion binding]; other site 1138382003400 basic sphincter; other site 1138382003401 hydrophobic gate; other site 1138382003402 periplasmic entrance; other site 1138382003403 malate dehydrogenase; Provisional; Region: PRK05442 1138382003404 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1138382003405 NAD(P) binding site [chemical binding]; other site 1138382003406 dimer interface [polypeptide binding]; other site 1138382003407 malate binding site [chemical binding]; other site 1138382003408 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1138382003409 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1138382003410 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1138382003411 putative NAD(P) binding site [chemical binding]; other site 1138382003412 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1138382003413 short chain dehydrogenase; Provisional; Region: PRK07832 1138382003414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003415 NAD(P) binding site [chemical binding]; other site 1138382003416 active site 1138382003417 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138382003418 classical (c) SDRs; Region: SDR_c; cd05233 1138382003419 NAD(P) binding site [chemical binding]; other site 1138382003420 active site 1138382003421 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1138382003422 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138382003423 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1138382003424 TPP-binding site [chemical binding]; other site 1138382003425 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1138382003426 dimer interface [polypeptide binding]; other site 1138382003427 PYR/PP interface [polypeptide binding]; other site 1138382003428 TPP binding site [chemical binding]; other site 1138382003429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382003430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138382003431 putative substrate translocation pore; other site 1138382003432 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1138382003433 RNase_H superfamily; Region: RNase_H_2; pfam13482 1138382003434 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1138382003435 Part of AAA domain; Region: AAA_19; pfam13245 1138382003436 AAA domain; Region: AAA_12; pfam13087 1138382003437 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138382003438 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1138382003439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138382003440 ATP binding site [chemical binding]; other site 1138382003441 Mg++ binding site [ion binding]; other site 1138382003442 motif III; other site 1138382003443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382003444 nucleotide binding region [chemical binding]; other site 1138382003445 ATP-binding site [chemical binding]; other site 1138382003446 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1138382003447 putative RNA binding site [nucleotide binding]; other site 1138382003448 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138382003449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003452 Cytochrome P450; Region: p450; cl12078 1138382003453 putative transposase OrfB; Reviewed; Region: PHA02517 1138382003454 HTH-like domain; Region: HTH_21; pfam13276 1138382003455 Integrase core domain; Region: rve; pfam00665 1138382003456 Integrase core domain; Region: rve_3; cl15866 1138382003457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138382003458 Transposase; Region: HTH_Tnp_1; cl17663 1138382003459 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1138382003460 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138382003461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003463 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382003464 Permease; Region: Permease; pfam02405 1138382003465 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382003466 Permease; Region: Permease; pfam02405 1138382003467 mce related protein; Region: MCE; pfam02470 1138382003468 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382003469 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003470 mce related protein; Region: MCE; pfam02470 1138382003471 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003472 mce related protein; Region: MCE; pfam02470 1138382003473 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003474 mce related protein; Region: MCE; pfam02470 1138382003475 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003476 mce related protein; Region: MCE; pfam02470 1138382003477 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382003478 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003479 mce related protein; Region: MCE; pfam02470 1138382003480 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1138382003481 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138382003482 active site 1138382003483 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138382003484 catalytic triad [active] 1138382003485 dimer interface [polypeptide binding]; other site 1138382003486 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382003487 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382003488 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138382003489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382003490 DNA-binding site [nucleotide binding]; DNA binding site 1138382003491 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138382003492 5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555 1138382003493 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382003494 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382003495 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382003496 [2Fe-2S] cluster binding site [ion binding]; other site 1138382003497 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382003498 hydrophobic ligand binding site; other site 1138382003499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003501 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1138382003502 catalytic triad [active] 1138382003503 conserved cis-peptide bond; other site 1138382003504 acyl-CoA synthetase; Provisional; Region: PRK13391 1138382003505 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003506 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382003507 acyl-activating enzyme (AAE) consensus motif; other site 1138382003508 putative AMP binding site [chemical binding]; other site 1138382003509 putative active site [active] 1138382003510 putative CoA binding site [chemical binding]; other site 1138382003511 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003512 Cytochrome P450; Region: p450; cl12078 1138382003513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382003515 NAD(P) binding site [chemical binding]; other site 1138382003516 active site 1138382003517 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382003518 classical (c) SDRs; Region: SDR_c; cd05233 1138382003519 NAD(P) binding site [chemical binding]; other site 1138382003520 active site 1138382003521 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382003522 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003523 substrate binding site [chemical binding]; other site 1138382003524 oxyanion hole (OAH) forming residues; other site 1138382003525 trimer interface [polypeptide binding]; other site 1138382003526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382003528 NAD(P) binding site [chemical binding]; other site 1138382003529 active site 1138382003530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003531 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003532 active site 1138382003533 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003534 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003535 active site 1138382003536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003537 NAD(P) binding site [chemical binding]; other site 1138382003538 active site 1138382003539 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003540 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138382003541 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003542 active site 1138382003543 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382003544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003545 substrate binding site [chemical binding]; other site 1138382003546 oxyanion hole (OAH) forming residues; other site 1138382003547 trimer interface [polypeptide binding]; other site 1138382003548 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1138382003549 active site 2 [active] 1138382003550 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138382003551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382003552 DNA-binding site [nucleotide binding]; DNA binding site 1138382003553 FCD domain; Region: FCD; pfam07729 1138382003554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003556 active site 1138382003557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003558 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003560 active site 1138382003561 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138382003562 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138382003563 NAD binding site [chemical binding]; other site 1138382003564 catalytic residues [active] 1138382003565 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382003566 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382003567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382003568 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382003569 active site 1138382003570 metal binding site [ion binding]; metal-binding site 1138382003571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003572 NAD(P) binding site [chemical binding]; other site 1138382003573 active site 1138382003574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003575 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138382003576 NAD(P) binding site [chemical binding]; other site 1138382003577 active site 1138382003578 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1138382003579 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003580 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382003581 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382003582 active site 1138382003583 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003584 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003585 active site 1138382003586 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382003587 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003588 acyl-activating enzyme (AAE) consensus motif; other site 1138382003589 AMP binding site [chemical binding]; other site 1138382003590 active site 1138382003591 CoA binding site [chemical binding]; other site 1138382003592 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003593 Cytochrome P450; Region: p450; cl12078 1138382003594 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138382003595 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003596 active site 1138382003597 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382003598 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382003599 acyl-activating enzyme (AAE) consensus motif; other site 1138382003600 putative AMP binding site [chemical binding]; other site 1138382003601 putative active site [active] 1138382003602 putative CoA binding site [chemical binding]; other site 1138382003603 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382003604 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382003605 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382003606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003608 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138382003609 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1138382003610 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003611 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382003612 putative acyltransferase; Provisional; Region: PRK05790 1138382003613 dimer interface [polypeptide binding]; other site 1138382003614 active site 1138382003615 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138382003616 putative active site [active] 1138382003617 putative catalytic site [active] 1138382003618 lipid-transfer protein; Provisional; Region: PRK07855 1138382003619 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003620 active site 1138382003621 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138382003622 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003623 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382003624 acyl-activating enzyme (AAE) consensus motif; other site 1138382003625 putative AMP binding site [chemical binding]; other site 1138382003626 putative active site [active] 1138382003627 putative CoA binding site [chemical binding]; other site 1138382003628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003632 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382003633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003634 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003635 active site 1138382003636 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138382003637 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003639 active site 1138382003640 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382003641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003645 active site 1138382003646 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382003647 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003648 active site 1138382003649 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382003650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003651 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003652 AMP binding site [chemical binding]; other site 1138382003653 active site 1138382003654 acyl-activating enzyme (AAE) consensus motif; other site 1138382003655 acyl-activating enzyme (AAE) consensus motif; other site 1138382003656 CoA binding site [chemical binding]; other site 1138382003657 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138382003658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003659 substrate binding site [chemical binding]; other site 1138382003660 oxyanion hole (OAH) forming residues; other site 1138382003661 trimer interface [polypeptide binding]; other site 1138382003662 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382003663 classical (c) SDRs; Region: SDR_c; cd05233 1138382003664 NAD(P) binding site [chemical binding]; other site 1138382003665 active site 1138382003666 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382003667 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382003668 active site 2 [active] 1138382003669 active site 1 [active] 1138382003670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003672 active site 1138382003673 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138382003674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003675 substrate binding site [chemical binding]; other site 1138382003676 oxyanion hole (OAH) forming residues; other site 1138382003677 trimer interface [polypeptide binding]; other site 1138382003678 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382003679 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138382003680 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138382003681 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382003682 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382003683 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382003684 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003686 active site 1138382003687 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1138382003688 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382003689 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1138382003690 NAD(P) binding site [chemical binding]; other site 1138382003691 catalytic residues [active] 1138382003692 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003693 enoyl-CoA hydratase; Provisional; Region: PRK07799 1138382003694 substrate binding site [chemical binding]; other site 1138382003695 oxyanion hole (OAH) forming residues; other site 1138382003696 trimer interface [polypeptide binding]; other site 1138382003697 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138382003698 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003699 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382003700 acyl-activating enzyme (AAE) consensus motif; other site 1138382003701 putative AMP binding site [chemical binding]; other site 1138382003702 putative active site [active] 1138382003703 putative CoA binding site [chemical binding]; other site 1138382003704 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1138382003705 inter-subunit interface; other site 1138382003706 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382003707 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382003708 iron-sulfur cluster [ion binding]; other site 1138382003709 [2Fe-2S] cluster binding site [ion binding]; other site 1138382003710 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1138382003711 putative alpha subunit interface [polypeptide binding]; other site 1138382003712 putative active site [active] 1138382003713 putative substrate binding site [chemical binding]; other site 1138382003714 Fe binding site [ion binding]; other site 1138382003715 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003716 lipid-transfer protein; Provisional; Region: PRK07855 1138382003717 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003718 active site 1138382003719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382003720 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1138382003721 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138382003722 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138382003723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003724 active site 1138382003725 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382003726 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003727 active site 1138382003728 thiolase; Provisional; Region: PRK06158 1138382003729 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003730 active site 1138382003731 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382003732 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003733 acyl-activating enzyme (AAE) consensus motif; other site 1138382003734 AMP binding site [chemical binding]; other site 1138382003735 active site 1138382003736 CoA binding site [chemical binding]; other site 1138382003737 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382003738 classical (c) SDRs; Region: SDR_c; cd05233 1138382003739 NAD(P) binding site [chemical binding]; other site 1138382003740 active site 1138382003741 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382003742 CoenzymeA binding site [chemical binding]; other site 1138382003743 subunit interaction site [polypeptide binding]; other site 1138382003744 PHB binding site; other site 1138382003745 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382003746 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382003747 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382003748 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382003749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003751 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382003752 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003753 lipid-transfer protein; Provisional; Region: PRK07855 1138382003754 active site 1138382003755 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382003756 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003757 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003759 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003760 Cytochrome P450; Region: p450; cl12078 1138382003761 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138382003762 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382003763 classical (c) SDRs; Region: SDR_c; cd05233 1138382003764 NAD(P) binding site [chemical binding]; other site 1138382003765 active site 1138382003766 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1138382003767 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138382003768 acyl-activating enzyme (AAE) consensus motif; other site 1138382003769 putative AMP binding site [chemical binding]; other site 1138382003770 putative active site [active] 1138382003771 putative CoA binding site [chemical binding]; other site 1138382003772 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382003773 short chain dehydrogenase; Provisional; Region: PRK07791 1138382003774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003775 NAD(P) binding site [chemical binding]; other site 1138382003776 active site 1138382003777 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382003778 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382003779 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003780 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138382003781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382003782 substrate binding site [chemical binding]; other site 1138382003783 oxyanion hole (OAH) forming residues; other site 1138382003784 trimer interface [polypeptide binding]; other site 1138382003785 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003786 Cytochrome P450; Region: p450; cl12078 1138382003787 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138382003788 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1138382003789 classical (c) SDRs; Region: SDR_c; cd05233 1138382003790 NAD(P) binding site [chemical binding]; other site 1138382003791 active site 1138382003792 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382003793 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382003794 NAD binding site [chemical binding]; other site 1138382003795 catalytic Zn binding site [ion binding]; other site 1138382003796 substrate binding site [chemical binding]; other site 1138382003797 structural Zn binding site [ion binding]; other site 1138382003798 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138382003799 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382003800 NAD binding site [chemical binding]; other site 1138382003801 catalytic residues [active] 1138382003802 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1138382003803 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382003804 active site 2 [active] 1138382003805 active site 1 [active] 1138382003806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003810 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382003811 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382003812 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382003813 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382003814 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 1138382003815 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1138382003816 active site 1138382003817 metal binding site [ion binding]; metal-binding site 1138382003818 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382003819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003820 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382003821 Cytochrome P450; Region: p450; cl12078 1138382003822 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382003823 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382003824 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 1138382003825 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1138382003826 putative FMN binding site [chemical binding]; other site 1138382003827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003828 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382003829 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003830 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003831 active site 1138382003832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003834 active site 1138382003835 lipid-transfer protein; Provisional; Region: PRK07855 1138382003836 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382003837 active site 1138382003838 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003839 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382003840 classical (c) SDRs; Region: SDR_c; cd05233 1138382003841 NAD(P) binding site [chemical binding]; other site 1138382003842 active site 1138382003843 Ecdysteroid kinase; Region: EcKinase; cl17738 1138382003844 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382003845 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382003846 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003847 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003848 active site 1138382003849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003850 short chain dehydrogenase; Provisional; Region: PRK06197 1138382003851 NAD(P) binding site [chemical binding]; other site 1138382003852 active site 1138382003853 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382003854 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003855 acyl-activating enzyme (AAE) consensus motif; other site 1138382003856 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382003857 AMP binding site [chemical binding]; other site 1138382003858 active site 1138382003859 acyl-activating enzyme (AAE) consensus motif; other site 1138382003860 CoA binding site [chemical binding]; other site 1138382003861 potential frameshift: common BLAST hit: gi|308178788|ref|YP_003918194.1| transposase of ISAar24, IS3 family, IS3 group, orfB 1138382003862 Integrase core domain; Region: rve; pfam00665 1138382003863 Integrase core domain; Region: rve_3; pfam13683 1138382003864 HTH-like domain; Region: HTH_21; pfam13276 1138382003865 Integrase core domain; Region: rve; pfam00665 1138382003866 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382003867 MarR family; Region: MarR_2; pfam12802 1138382003868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1138382003869 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1138382003870 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1138382003871 active site 1138382003872 catalytic residues [active] 1138382003873 metal binding site [ion binding]; metal-binding site 1138382003874 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1138382003875 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1138382003876 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138382003877 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1138382003878 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1138382003879 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1138382003880 dimer interface [polypeptide binding]; other site 1138382003881 PYR/PP interface [polypeptide binding]; other site 1138382003882 TPP binding site [chemical binding]; other site 1138382003883 substrate binding site [chemical binding]; other site 1138382003884 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1138382003885 TPP-binding site [chemical binding]; other site 1138382003886 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1138382003887 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1138382003888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382003889 putative DNA binding site [nucleotide binding]; other site 1138382003890 putative Zn2+ binding site [ion binding]; other site 1138382003891 AsnC family; Region: AsnC_trans_reg; pfam01037 1138382003892 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382003893 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382003894 iron-sulfur cluster [ion binding]; other site 1138382003895 [2Fe-2S] cluster binding site [ion binding]; other site 1138382003896 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1138382003897 beta subunit interface [polypeptide binding]; other site 1138382003898 alpha subunit interface [polypeptide binding]; other site 1138382003899 active site 1138382003900 substrate binding site [chemical binding]; other site 1138382003901 Fe binding site [ion binding]; other site 1138382003902 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1138382003903 inter-subunit interface; other site 1138382003904 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1138382003905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382003906 NAD(P) binding site [chemical binding]; other site 1138382003907 active site 1138382003908 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138382003909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382003910 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138382003911 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382003912 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138382003913 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382003914 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382003915 MarR family; Region: MarR; pfam01047 1138382003916 MarR family; Region: MarR_2; cl17246 1138382003917 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382003918 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 1138382003919 NAD(P) binding site [chemical binding]; other site 1138382003920 catalytic residues [active] 1138382003921 catalytic residues [active] 1138382003922 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138382003923 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138382003924 active site 1138382003925 metal binding site [ion binding]; metal-binding site 1138382003926 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 1138382003927 active site 1138382003928 metal binding site [ion binding]; metal-binding site 1138382003929 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1138382003930 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1138382003931 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1138382003932 hexamer interface [polypeptide binding]; other site 1138382003933 active site 2 [active] 1138382003934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382003935 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1138382003936 NAD binding site [chemical binding]; other site 1138382003937 catalytic residues [active] 1138382003938 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138382003939 Class I aldolases; Region: Aldolase_Class_I; cl17187 1138382003940 catalytic residue [active] 1138382003941 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1138382003942 Cupin domain; Region: Cupin_2; pfam07883 1138382003943 Cupin domain; Region: Cupin_2; pfam07883 1138382003944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003946 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382003947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382003948 active site 1138382003949 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382003950 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382003951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382003952 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382003953 active site 1138382003954 metal binding site [ion binding]; metal-binding site 1138382003955 classical (c) SDRs; Region: SDR_c; cd05233 1138382003956 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138382003957 NAD(P) binding site [chemical binding]; other site 1138382003958 active site 1138382003959 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382003960 iron-sulfur cluster [ion binding]; other site 1138382003961 [2Fe-2S] cluster binding site [ion binding]; other site 1138382003962 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382003963 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382003964 hydrophobic ligand binding site; other site 1138382003965 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382003966 YceI-like domain; Region: YceI; pfam04264 1138382003967 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138382003968 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138382003969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382003970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382003971 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138382003972 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382003973 Permease; Region: Permease; pfam02405 1138382003974 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382003975 Permease; Region: Permease; pfam02405 1138382003976 mce related protein; Region: MCE; pfam02470 1138382003977 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382003978 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003979 mce related protein; Region: MCE; pfam02470 1138382003980 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003981 mce related protein; Region: MCE; pfam02470 1138382003982 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138382003983 mce related protein; Region: MCE; pfam02470 1138382003984 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382003985 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382003986 mce related protein; Region: MCE; pfam02470 1138382003987 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382003988 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138382003989 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1138382003990 Fe-S cluster binding site [ion binding]; other site 1138382003991 DNA binding site [nucleotide binding] 1138382003992 active site 1138382003993 hypothetical protein; Validated; Region: PRK05868 1138382003994 hypothetical protein; Provisional; Region: PRK07236 1138382003995 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382003996 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1138382003997 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138382003998 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138382003999 metal binding site [ion binding]; metal-binding site 1138382004000 active site 1138382004001 I-site; other site 1138382004002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138382004003 metal binding site [ion binding]; metal-binding site 1138382004004 active site 1138382004005 I-site; other site 1138382004006 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138382004007 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1138382004008 HIT family signature motif; other site 1138382004009 catalytic residue [active] 1138382004010 amidase; Provisional; Region: PRK12470 1138382004011 Amidase; Region: Amidase; pfam01425 1138382004012 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1138382004013 putative active site [active] 1138382004014 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382004015 cyclase homology domain; Region: CHD; cd07302 1138382004016 nucleotidyl binding site; other site 1138382004017 metal binding site [ion binding]; metal-binding site 1138382004018 dimer interface [polypeptide binding]; other site 1138382004019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382004020 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382004021 active site 1138382004022 ATP binding site [chemical binding]; other site 1138382004023 substrate binding site [chemical binding]; other site 1138382004024 activation loop (A-loop); other site 1138382004025 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382004026 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138382004027 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1138382004028 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138382004029 Walker A/P-loop; other site 1138382004030 ATP binding site [chemical binding]; other site 1138382004031 Q-loop/lid; other site 1138382004032 ABC transporter signature motif; other site 1138382004033 Walker B; other site 1138382004034 D-loop; other site 1138382004035 H-loop/switch region; other site 1138382004036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138382004037 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138382004038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382004039 Walker A/P-loop; other site 1138382004040 ATP binding site [chemical binding]; other site 1138382004041 Q-loop/lid; other site 1138382004042 ABC transporter signature motif; other site 1138382004043 Walker B; other site 1138382004044 D-loop; other site 1138382004045 H-loop/switch region; other site 1138382004046 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138382004047 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138382004048 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382004049 catalytic core [active] 1138382004050 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1138382004051 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1138382004052 active site 1138382004053 metal binding site [ion binding]; metal-binding site 1138382004054 DNA binding site [nucleotide binding] 1138382004055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382004056 Walker A/P-loop; other site 1138382004057 ATP binding site [chemical binding]; other site 1138382004058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382004059 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138382004060 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138382004061 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1138382004062 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138382004063 Walker A/P-loop; other site 1138382004064 ATP binding site [chemical binding]; other site 1138382004065 Q-loop/lid; other site 1138382004066 ABC transporter signature motif; other site 1138382004067 Walker B; other site 1138382004068 D-loop; other site 1138382004069 H-loop/switch region; other site 1138382004070 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138382004071 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138382004072 Walker A/P-loop; other site 1138382004073 ATP binding site [chemical binding]; other site 1138382004074 Q-loop/lid; other site 1138382004075 ABC transporter signature motif; other site 1138382004076 Walker B; other site 1138382004077 D-loop; other site 1138382004078 H-loop/switch region; other site 1138382004079 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1138382004080 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1138382004081 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1138382004082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382004083 dimer interface [polypeptide binding]; other site 1138382004084 conserved gate region; other site 1138382004085 putative PBP binding loops; other site 1138382004086 ABC-ATPase subunit interface; other site 1138382004087 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1138382004088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382004089 dimer interface [polypeptide binding]; other site 1138382004090 conserved gate region; other site 1138382004091 putative PBP binding loops; other site 1138382004092 ABC-ATPase subunit interface; other site 1138382004093 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1138382004094 active site clefts [active] 1138382004095 zinc binding site [ion binding]; other site 1138382004096 dimer interface [polypeptide binding]; other site 1138382004097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382004098 CoenzymeA binding site [chemical binding]; other site 1138382004099 subunit interaction site [polypeptide binding]; other site 1138382004100 PHB binding site; other site 1138382004101 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1138382004102 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138382004103 Active Sites [active] 1138382004104 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1138382004105 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1138382004106 CysD dimerization site [polypeptide binding]; other site 1138382004107 G1 box; other site 1138382004108 putative GEF interaction site [polypeptide binding]; other site 1138382004109 GTP/Mg2+ binding site [chemical binding]; other site 1138382004110 Switch I region; other site 1138382004111 G2 box; other site 1138382004112 G3 box; other site 1138382004113 Switch II region; other site 1138382004114 G4 box; other site 1138382004115 G5 box; other site 1138382004116 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1138382004117 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1138382004118 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138382004119 ligand-binding site [chemical binding]; other site 1138382004120 Rrf2 family protein; Region: rrf2_super; TIGR00738 1138382004121 Transcriptional regulator; Region: Rrf2; pfam02082 1138382004122 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 1138382004123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382004124 metal binding site [ion binding]; metal-binding site 1138382004125 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1138382004126 putative dimer interface [polypeptide binding]; other site 1138382004127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382004128 ligand binding site [chemical binding]; other site 1138382004129 Zn binding site [ion binding]; other site 1138382004130 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382004131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1138382004132 TrkA-N domain; Region: TrkA_N; pfam02254 1138382004133 Ion channel; Region: Ion_trans_2; pfam07885 1138382004134 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138382004135 TrkA-N domain; Region: TrkA_N; pfam02254 1138382004136 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382004137 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1138382004138 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1138382004139 dimer interface [polypeptide binding]; other site 1138382004140 ADP-ribose binding site [chemical binding]; other site 1138382004141 active site 1138382004142 nudix motif; other site 1138382004143 metal binding site [ion binding]; metal-binding site 1138382004144 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1138382004145 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138382004146 active site 1138382004147 catalytic residues [active] 1138382004148 DNA binding site [nucleotide binding] 1138382004149 Int/Topo IB signature motif; other site 1138382004150 putative transposase OrfB; Reviewed; Region: PHA02517 1138382004151 HTH-like domain; Region: HTH_21; pfam13276 1138382004152 Integrase core domain; Region: rve; pfam00665 1138382004153 Integrase core domain; Region: rve_3; cl15866 1138382004154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138382004155 Transposase; Region: HTH_Tnp_1; cl17663 1138382004156 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138382004157 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1138382004158 polymerase nucleotide-binding site; other site 1138382004159 DNA-binding residues [nucleotide binding]; DNA binding site 1138382004160 nucleotide binding site [chemical binding]; other site 1138382004161 primase nucleotide-binding site [nucleotide binding]; other site 1138382004162 AAA domain; Region: AAA_25; pfam13481 1138382004163 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138382004164 Walker A motif; other site 1138382004165 ATP binding site [chemical binding]; other site 1138382004166 Walker B motif; other site 1138382004167 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138382004168 NlpC/P60 family; Region: NLPC_P60; cl17555 1138382004169 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138382004170 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1138382004171 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1138382004172 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1138382004173 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1138382004174 active site 1138382004175 HIGH motif; other site 1138382004176 KMSK motif region; other site 1138382004177 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1138382004178 tRNA binding surface [nucleotide binding]; other site 1138382004179 anticodon binding site; other site 1138382004180 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1138382004181 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1138382004182 active site 1138382004183 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138382004184 substrate binding site [chemical binding]; other site 1138382004185 catalytic residues [active] 1138382004186 dimer interface [polypeptide binding]; other site 1138382004187 homoserine dehydrogenase; Provisional; Region: PRK06349 1138382004188 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1138382004189 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1138382004190 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1138382004191 threonine synthase; Reviewed; Region: PRK06721 1138382004192 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1138382004193 homodimer interface [polypeptide binding]; other site 1138382004194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382004195 catalytic residue [active] 1138382004196 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1138382004197 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1138382004198 transcription termination factor Rho; Provisional; Region: PRK12608 1138382004199 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138382004200 RNA binding site [nucleotide binding]; other site 1138382004201 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1138382004202 multimer interface [polypeptide binding]; other site 1138382004203 Walker A motif; other site 1138382004204 ATP binding site [chemical binding]; other site 1138382004205 Walker B motif; other site 1138382004206 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1138382004207 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1138382004208 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138382004209 RF-1 domain; Region: RF-1; pfam00472 1138382004210 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1138382004211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382004212 S-adenosylmethionine binding site [chemical binding]; other site 1138382004213 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1138382004214 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1138382004215 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1138382004216 Mg++ binding site [ion binding]; other site 1138382004217 putative catalytic motif [active] 1138382004218 substrate binding site [chemical binding]; other site 1138382004219 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1138382004220 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1138382004221 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1138382004222 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1138382004223 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1138382004224 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1138382004225 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138382004226 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1138382004227 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1138382004228 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138382004229 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1138382004230 beta subunit interaction interface [polypeptide binding]; other site 1138382004231 Walker A motif; other site 1138382004232 ATP binding site [chemical binding]; other site 1138382004233 Walker B motif; other site 1138382004234 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138382004235 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1138382004236 core domain interface [polypeptide binding]; other site 1138382004237 delta subunit interface [polypeptide binding]; other site 1138382004238 epsilon subunit interface [polypeptide binding]; other site 1138382004239 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1138382004240 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138382004241 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1138382004242 alpha subunit interaction interface [polypeptide binding]; other site 1138382004243 Walker A motif; other site 1138382004244 ATP binding site [chemical binding]; other site 1138382004245 Walker B motif; other site 1138382004246 inhibitor binding site; inhibition site 1138382004247 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138382004248 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1138382004249 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1138382004250 gamma subunit interface [polypeptide binding]; other site 1138382004251 epsilon subunit interface [polypeptide binding]; other site 1138382004252 LBP interface [polypeptide binding]; other site 1138382004253 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1138382004254 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1138382004255 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1138382004256 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1138382004257 hinge; other site 1138382004258 active site 1138382004259 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382004260 PPE family; Region: PPE; pfam00823 1138382004261 PE family; Region: PE; pfam00934 1138382004262 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382004263 PPE family; Region: PPE; pfam00823 1138382004264 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382004265 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1138382004266 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1138382004267 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138382004268 DNA binding site [nucleotide binding] 1138382004269 active site 1138382004270 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1138382004271 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1138382004272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382004273 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1138382004274 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138382004275 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138382004276 minor groove reading motif; other site 1138382004277 helix-hairpin-helix signature motif; other site 1138382004278 substrate binding pocket [chemical binding]; other site 1138382004279 active site 1138382004280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138382004281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138382004282 metal binding site [ion binding]; metal-binding site 1138382004283 active site 1138382004284 I-site; other site 1138382004285 HAMP domain; Region: HAMP; pfam00672 1138382004286 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382004287 cyclase homology domain; Region: CHD; cd07302 1138382004288 nucleotidyl binding site; other site 1138382004289 metal binding site [ion binding]; metal-binding site 1138382004290 dimer interface [polypeptide binding]; other site 1138382004291 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1138382004292 hypothetical protein; Provisional; Region: PRK03298 1138382004293 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1138382004294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382004295 dimer interface [polypeptide binding]; other site 1138382004296 substrate binding site [chemical binding]; other site 1138382004297 metal binding site [ion binding]; metal-binding site 1138382004298 putative acyltransferase; Provisional; Region: PRK05790 1138382004299 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382004300 dimer interface [polypeptide binding]; other site 1138382004301 active site 1138382004302 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1138382004303 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1138382004304 glycogen branching enzyme; Provisional; Region: PRK05402 1138382004305 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1138382004306 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1138382004307 active site 1138382004308 catalytic site [active] 1138382004309 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1138382004310 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1138382004311 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138382004312 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1138382004313 active site 1138382004314 homodimer interface [polypeptide binding]; other site 1138382004315 catalytic site [active] 1138382004316 acceptor binding site [chemical binding]; other site 1138382004317 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1138382004318 putative homodimer interface [polypeptide binding]; other site 1138382004319 putative active site pocket [active] 1138382004320 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1138382004321 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1138382004322 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1138382004323 ATP binding site [chemical binding]; other site 1138382004324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138382004325 putative Mg++ binding site [ion binding]; other site 1138382004326 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1138382004327 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1138382004328 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1138382004329 active site 1138382004330 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1138382004331 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1138382004332 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1138382004333 putative active site pocket [active] 1138382004334 cleavage site 1138382004335 Rhomboid family; Region: Rhomboid; pfam01694 1138382004336 glutamate racemase; Provisional; Region: PRK00865 1138382004337 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1138382004338 ribonuclease PH; Reviewed; Region: rph; PRK00173 1138382004339 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1138382004340 hexamer interface [polypeptide binding]; other site 1138382004341 active site 1138382004342 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1138382004343 active site 1138382004344 dimerization interface [polypeptide binding]; other site 1138382004345 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1138382004346 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1138382004347 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1138382004348 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1138382004349 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138382004350 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138382004351 FAD binding pocket [chemical binding]; other site 1138382004352 FAD binding motif [chemical binding]; other site 1138382004353 phosphate binding motif [ion binding]; other site 1138382004354 NAD binding pocket [chemical binding]; other site 1138382004355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138382004356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382004357 Walker A/P-loop; other site 1138382004358 ATP binding site [chemical binding]; other site 1138382004359 Q-loop/lid; other site 1138382004360 ABC transporter signature motif; other site 1138382004361 Walker B; other site 1138382004362 D-loop; other site 1138382004363 H-loop/switch region; other site 1138382004364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382004365 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138382004366 Walker A/P-loop; other site 1138382004367 ATP binding site [chemical binding]; other site 1138382004368 Q-loop/lid; other site 1138382004369 ABC transporter signature motif; other site 1138382004370 Walker B; other site 1138382004371 D-loop; other site 1138382004372 H-loop/switch region; other site 1138382004373 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382004374 Ecdysteroid kinase; Region: EcKinase; cl17738 1138382004375 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382004376 cyclase homology domain; Region: CHD; cd07302 1138382004377 nucleotidyl binding site; other site 1138382004378 metal binding site [ion binding]; metal-binding site 1138382004379 dimer interface [polypeptide binding]; other site 1138382004380 Predicted ATPase [General function prediction only]; Region: COG3903 1138382004381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382004382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382004383 DNA binding residues [nucleotide binding] 1138382004384 dimerization interface [polypeptide binding]; other site 1138382004385 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382004386 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382004387 classical (c) SDRs; Region: SDR_c; cd05233 1138382004388 NAD(P) binding site [chemical binding]; other site 1138382004389 active site 1138382004390 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004391 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004392 active site 1138382004393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382004394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382004395 NAD(P) binding site [chemical binding]; other site 1138382004396 active site 1138382004397 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1138382004398 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382004399 dimer interface [polypeptide binding]; other site 1138382004400 active site 1138382004401 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1138382004402 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382004403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004405 active site 1138382004406 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138382004407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382004408 DNA-binding site [nucleotide binding]; DNA binding site 1138382004409 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138382004410 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1138382004411 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138382004412 conserved cys residue [active] 1138382004413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382004414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382004415 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138382004416 conserved cys residue [active] 1138382004417 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382004418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382004419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382004420 acyl-activating enzyme (AAE) consensus motif; other site 1138382004421 acyl-activating enzyme (AAE) consensus motif; other site 1138382004422 AMP binding site [chemical binding]; other site 1138382004423 active site 1138382004424 CoA binding site [chemical binding]; other site 1138382004425 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382004426 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382004427 acyl-activating enzyme (AAE) consensus motif; other site 1138382004428 AMP binding site [chemical binding]; other site 1138382004429 active site 1138382004430 CoA binding site [chemical binding]; other site 1138382004431 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382004432 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382004433 AMP binding site [chemical binding]; other site 1138382004434 active site 1138382004435 acyl-activating enzyme (AAE) consensus motif; other site 1138382004436 CoA binding site [chemical binding]; other site 1138382004437 enoyl-CoA hydratase; Provisional; Region: PRK05981 1138382004438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382004439 substrate binding site [chemical binding]; other site 1138382004440 oxyanion hole (OAH) forming residues; other site 1138382004441 trimer interface [polypeptide binding]; other site 1138382004442 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382004443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382004444 substrate binding site [chemical binding]; other site 1138382004445 oxyanion hole (OAH) forming residues; other site 1138382004446 trimer interface [polypeptide binding]; other site 1138382004447 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382004448 substrate binding site [chemical binding]; other site 1138382004449 oxyanion hole (OAH) forming residues; other site 1138382004450 trimer interface [polypeptide binding]; other site 1138382004451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382004452 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1138382004453 substrate binding site [chemical binding]; other site 1138382004454 oxyanion hole (OAH) forming residues; other site 1138382004455 trimer interface [polypeptide binding]; other site 1138382004456 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138382004457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382004458 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138382004459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382004460 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382004461 NAD(P) binding site [chemical binding]; other site 1138382004462 active site 1138382004463 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138382004464 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1138382004465 active site 1138382004466 inhibitor site; inhibition site 1138382004467 dimer interface [polypeptide binding]; other site 1138382004468 catalytic residue [active] 1138382004469 CsbD-like; Region: CsbD; cl17424 1138382004470 enoyl-CoA hydratase; Provisional; Region: PRK06210 1138382004471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382004472 substrate binding site [chemical binding]; other site 1138382004473 oxyanion hole (OAH) forming residues; other site 1138382004474 trimer interface [polypeptide binding]; other site 1138382004475 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382004476 acyl-CoA synthetase; Validated; Region: PRK07798 1138382004477 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382004478 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138382004479 acyl-activating enzyme (AAE) consensus motif; other site 1138382004480 acyl-activating enzyme (AAE) consensus motif; other site 1138382004481 putative AMP binding site [chemical binding]; other site 1138382004482 putative active site [active] 1138382004483 putative CoA binding site [chemical binding]; other site 1138382004484 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382004485 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138382004486 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382004487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004489 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004490 active site 1138382004491 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382004492 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138382004493 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382004494 active site 1138382004495 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382004496 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382004497 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382004498 Cytochrome P450; Region: p450; cl12078 1138382004499 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382004500 NAD(P) binding site [chemical binding]; other site 1138382004501 catalytic residues [active] 1138382004502 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382004503 Cytochrome P450; Region: p450; cl12078 1138382004504 short chain dehydrogenase; Provisional; Region: PRK07832 1138382004505 classical (c) SDRs; Region: SDR_c; cd05233 1138382004506 NAD(P) binding site [chemical binding]; other site 1138382004507 active site 1138382004508 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382004509 hydrophobic ligand binding site; other site 1138382004510 acyl-CoA synthetase; Validated; Region: PRK07798 1138382004511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382004512 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138382004513 acyl-activating enzyme (AAE) consensus motif; other site 1138382004514 acyl-activating enzyme (AAE) consensus motif; other site 1138382004515 putative AMP binding site [chemical binding]; other site 1138382004516 putative active site [active] 1138382004517 putative CoA binding site [chemical binding]; other site 1138382004518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382004519 CoenzymeA binding site [chemical binding]; other site 1138382004520 subunit interaction site [polypeptide binding]; other site 1138382004521 PHB binding site; other site 1138382004522 Isochorismatase family; Region: Isochorismatase; pfam00857 1138382004523 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138382004524 catalytic triad [active] 1138382004525 conserved cis-peptide bond; other site 1138382004526 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382004527 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382004528 [2Fe-2S] cluster binding site [ion binding]; other site 1138382004529 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382004530 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382004531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382004532 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382004533 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1138382004534 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382004535 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138382004536 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138382004537 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382004538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382004539 Cytochrome P450; Region: p450; cl12078 1138382004540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382004541 short chain dehydrogenase; Provisional; Region: PRK06197 1138382004542 NAD(P) binding site [chemical binding]; other site 1138382004543 active site 1138382004544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382004545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382004546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382004547 Walker A/P-loop; other site 1138382004548 ATP binding site [chemical binding]; other site 1138382004549 Predicted membrane protein [Function unknown]; Region: COG1511 1138382004550 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1138382004551 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1138382004552 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382004553 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382004554 NAD binding site [chemical binding]; other site 1138382004555 catalytic Zn binding site [ion binding]; other site 1138382004556 substrate binding site [chemical binding]; other site 1138382004557 structural Zn binding site [ion binding]; other site 1138382004558 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382004559 Cytochrome P450; Region: p450; cl12078 1138382004560 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382004561 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382004562 substrate binding pocket [chemical binding]; other site 1138382004563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004564 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382004565 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382004566 active site 1138382004567 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004568 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004569 active site 1138382004570 PAS fold; Region: PAS_4; pfam08448 1138382004571 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138382004572 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138382004573 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138382004574 ATP binding site [chemical binding]; other site 1138382004575 Mg2+ binding site [ion binding]; other site 1138382004576 G-X-G motif; other site 1138382004577 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382004578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382004579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382004580 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382004581 CoenzymeA binding site [chemical binding]; other site 1138382004582 subunit interaction site [polypeptide binding]; other site 1138382004583 PHB binding site; other site 1138382004584 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382004585 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382004586 putative AMP binding site [chemical binding]; other site 1138382004587 putative active site [active] 1138382004588 acyl-activating enzyme (AAE) consensus motif; other site 1138382004589 putative CoA binding site [chemical binding]; other site 1138382004590 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1138382004591 active site 1138382004592 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004593 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004594 active site 1138382004595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004597 active site 1138382004598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004599 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004600 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382004601 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382004602 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138382004603 classical (c) SDRs; Region: SDR_c; cd05233 1138382004604 NAD(P) binding site [chemical binding]; other site 1138382004605 active site 1138382004606 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138382004607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382004608 DNA-binding site [nucleotide binding]; DNA binding site 1138382004609 FCD domain; Region: FCD; pfam07729 1138382004610 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382004611 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382004612 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382004613 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382004614 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138382004615 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138382004616 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382004617 Cytochrome P450; Region: p450; cl12078 1138382004618 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382004619 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382004620 [2Fe-2S] cluster binding site [ion binding]; other site 1138382004621 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382004622 hydrophobic ligand binding site; other site 1138382004623 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1138382004624 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1138382004625 acyl-activating enzyme (AAE) consensus motif; other site 1138382004626 putative AMP binding site [chemical binding]; other site 1138382004627 putative active site [active] 1138382004628 putative CoA binding site [chemical binding]; other site 1138382004629 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382004630 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138382004631 active site 1138382004632 catalytic site [active] 1138382004633 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138382004634 putative active site [active] 1138382004635 putative catalytic site [active] 1138382004636 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138382004637 TIGR03086 family protein; Region: TIGR03086 1138382004638 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138382004639 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382004640 NAD binding site [chemical binding]; other site 1138382004641 catalytic residues [active] 1138382004642 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1138382004643 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382004644 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382004645 [2Fe-2S] cluster binding site [ion binding]; other site 1138382004646 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1138382004647 putative alpha subunit interface [polypeptide binding]; other site 1138382004648 putative active site [active] 1138382004649 putative substrate binding site [chemical binding]; other site 1138382004650 Fe binding site [ion binding]; other site 1138382004651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382004652 sequence-specific DNA binding site [nucleotide binding]; other site 1138382004653 salt bridge; other site 1138382004654 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1138382004655 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138382004656 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1138382004657 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138382004658 phosphate binding site [ion binding]; other site 1138382004659 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1138382004660 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1138382004661 putative active site [active] 1138382004662 putative catalytic site [active] 1138382004663 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138382004664 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138382004665 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1138382004666 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1138382004667 putative NAD(P) binding site [chemical binding]; other site 1138382004668 active site 1138382004669 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1138382004670 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1138382004671 active site 1138382004672 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1138382004673 hypothetical protein; Provisional; Region: PRK07907 1138382004674 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1138382004675 active site 1138382004676 metal binding site [ion binding]; metal-binding site 1138382004677 dimer interface [polypeptide binding]; other site 1138382004678 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382004679 Cytochrome P450; Region: p450; cl12078 1138382004680 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138382004681 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138382004682 catalytic triad [active] 1138382004683 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1138382004684 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138382004685 hypothetical protein; Provisional; Region: PRK01346 1138382004686 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1138382004687 MMPL family; Region: MMPL; pfam03176 1138382004688 MMPL family; Region: MMPL; pfam03176 1138382004689 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138382004690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138382004691 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138382004692 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138382004693 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1138382004694 catalytic site [active] 1138382004695 putative active site [active] 1138382004696 putative substrate binding site [chemical binding]; other site 1138382004697 dimer interface [polypeptide binding]; other site 1138382004698 potential frameshift: common BLAST hit: gi|375141561|ref|YP_005002210.1| transposase 1138382004699 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382004700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382004701 potential frameshift: common BLAST hit: gi|375140386|ref|YP_005001035.1| transposase 1138382004702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382004703 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382004704 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1138382004705 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138382004706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382004707 NAD(P) binding site [chemical binding]; other site 1138382004708 active site 1138382004709 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1138382004710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382004711 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382004712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382004713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382004714 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1138382004715 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138382004716 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382004717 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138382004718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382004719 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138382004720 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138382004721 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138382004722 carboxyltransferase (CT) interaction site; other site 1138382004723 biotinylation site [posttranslational modification]; other site 1138382004724 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382004725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382004726 active site 1138382004727 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1138382004728 putative active site [active] 1138382004729 putative catalytic site [active] 1138382004730 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138382004731 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1138382004732 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138382004733 tetramer interface [polypeptide binding]; other site 1138382004734 TPP-binding site [chemical binding]; other site 1138382004735 heterodimer interface [polypeptide binding]; other site 1138382004736 phosphorylation loop region [posttranslational modification] 1138382004737 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1138382004738 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1138382004739 alpha subunit interface [polypeptide binding]; other site 1138382004740 TPP binding site [chemical binding]; other site 1138382004741 heterodimer interface [polypeptide binding]; other site 1138382004742 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138382004743 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138382004744 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1138382004745 E3 interaction surface; other site 1138382004746 lipoyl attachment site [posttranslational modification]; other site 1138382004747 e3 binding domain; Region: E3_binding; pfam02817 1138382004748 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138382004749 enoyl-CoA hydratase; Provisional; Region: PRK05870 1138382004750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382004751 substrate binding site [chemical binding]; other site 1138382004752 oxyanion hole (OAH) forming residues; other site 1138382004753 trimer interface [polypeptide binding]; other site 1138382004754 Helix-turn-helix domain; Region: HTH_28; pfam13518 1138382004755 putative transposase OrfB; Reviewed; Region: PHA02517 1138382004756 Homeodomain-like domain; Region: HTH_32; pfam13565 1138382004757 Integrase core domain; Region: rve; pfam00665 1138382004758 Integrase core domain; Region: rve_3; pfam13683 1138382004759 putative transposase OrfB; Reviewed; Region: PHA02517 1138382004760 HTH-like domain; Region: HTH_21; pfam13276 1138382004761 Integrase core domain; Region: rve; pfam00665 1138382004762 Integrase core domain; Region: rve_3; pfam13683 1138382004763 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138382004764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382004765 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382004766 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382004767 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382004768 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138382004769 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1138382004770 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382004771 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138382004772 putative acyl-acceptor binding pocket; other site 1138382004773 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1138382004774 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138382004775 putative acyl-acceptor binding pocket; other site 1138382004776 Copper resistance protein D; Region: CopD; pfam05425 1138382004777 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1138382004778 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1138382004779 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138382004780 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138382004781 dimer interface [polypeptide binding]; other site 1138382004782 ssDNA binding site [nucleotide binding]; other site 1138382004783 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138382004784 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1138382004785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382004786 Walker A/P-loop; other site 1138382004787 ATP binding site [chemical binding]; other site 1138382004788 Q-loop/lid; other site 1138382004789 ABC transporter signature motif; other site 1138382004790 Walker B; other site 1138382004791 D-loop; other site 1138382004792 H-loop/switch region; other site 1138382004793 ABC transporter; Region: ABC_tran_2; pfam12848 1138382004794 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138382004795 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1138382004796 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138382004797 active site 1138382004798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382004799 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1138382004800 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138382004801 active site 1138382004802 catalytic site [active] 1138382004803 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138382004804 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1138382004805 apolar tunnel; other site 1138382004806 heme binding site [chemical binding]; other site 1138382004807 dimerization interface [polypeptide binding]; other site 1138382004808 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1138382004809 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382004810 active site 1138382004811 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1138382004812 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1138382004813 Zn binding site [ion binding]; other site 1138382004814 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138382004815 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1138382004816 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138382004817 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1138382004818 putative DNA binding site [nucleotide binding]; other site 1138382004819 catalytic residue [active] 1138382004820 putative H2TH interface [polypeptide binding]; other site 1138382004821 putative catalytic residues [active] 1138382004822 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138382004823 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138382004824 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382004825 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382004826 trigger factor; Provisional; Region: tig; PRK01490 1138382004827 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1138382004828 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1138382004829 Clp protease; Region: CLP_protease; pfam00574 1138382004830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138382004831 oligomer interface [polypeptide binding]; other site 1138382004832 active site residues [active] 1138382004833 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1138382004834 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138382004835 oligomer interface [polypeptide binding]; other site 1138382004836 active site residues [active] 1138382004837 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1138382004838 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1138382004839 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1138382004840 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1138382004841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382004842 Walker A motif; other site 1138382004843 ATP binding site [chemical binding]; other site 1138382004844 Walker B motif; other site 1138382004845 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1138382004846 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1138382004847 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1138382004848 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1138382004849 dimer interface [polypeptide binding]; other site 1138382004850 PYR/PP interface [polypeptide binding]; other site 1138382004851 TPP binding site [chemical binding]; other site 1138382004852 substrate binding site [chemical binding]; other site 1138382004853 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1138382004854 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1138382004855 TPP-binding site [chemical binding]; other site 1138382004856 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1138382004857 GTP binding site; other site 1138382004858 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138382004859 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1138382004860 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1138382004861 NAD(P) binding pocket [chemical binding]; other site 1138382004862 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1138382004863 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382004864 active site 1138382004865 HIGH motif; other site 1138382004866 nucleotide binding site [chemical binding]; other site 1138382004867 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138382004868 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1138382004869 active site 1138382004870 KMSKS motif; other site 1138382004871 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1138382004872 tRNA binding surface [nucleotide binding]; other site 1138382004873 anticodon binding site; other site 1138382004874 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1138382004875 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1138382004876 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138382004877 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1138382004878 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1138382004879 active site 1138382004880 multimer interface [polypeptide binding]; other site 1138382004881 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1138382004882 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1138382004883 homodimer interface [polypeptide binding]; other site 1138382004884 oligonucleotide binding site [chemical binding]; other site 1138382004885 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1138382004886 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1138382004887 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1138382004888 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1138382004889 GTP1/OBG; Region: GTP1_OBG; pfam01018 1138382004890 Obg GTPase; Region: Obg; cd01898 1138382004891 G1 box; other site 1138382004892 GTP/Mg2+ binding site [chemical binding]; other site 1138382004893 Switch I region; other site 1138382004894 G2 box; other site 1138382004895 G3 box; other site 1138382004896 Switch II region; other site 1138382004897 G4 box; other site 1138382004898 G5 box; other site 1138382004899 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1138382004900 gamma-glutamyl kinase; Provisional; Region: PRK05429 1138382004901 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1138382004902 nucleotide binding site [chemical binding]; other site 1138382004903 homotetrameric interface [polypeptide binding]; other site 1138382004904 putative phosphate binding site [ion binding]; other site 1138382004905 putative allosteric binding site; other site 1138382004906 PUA domain; Region: PUA; pfam01472 1138382004907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382004908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382004909 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382004910 Cytochrome P450; Region: p450; cl12078 1138382004911 NAD-dependent deacetylase; Provisional; Region: PRK00481 1138382004912 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1138382004913 NAD+ binding site [chemical binding]; other site 1138382004914 substrate binding site [chemical binding]; other site 1138382004915 Zn binding site [ion binding]; other site 1138382004916 Isochorismatase family; Region: Isochorismatase; pfam00857 1138382004917 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138382004918 catalytic triad [active] 1138382004919 conserved cis-peptide bond; other site 1138382004920 NAD synthetase; Reviewed; Region: nadE; PRK02628 1138382004921 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1138382004922 multimer interface [polypeptide binding]; other site 1138382004923 active site 1138382004924 catalytic triad [active] 1138382004925 protein interface 1 [polypeptide binding]; other site 1138382004926 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1138382004927 homodimer interface [polypeptide binding]; other site 1138382004928 NAD binding pocket [chemical binding]; other site 1138382004929 ATP binding pocket [chemical binding]; other site 1138382004930 Mg binding site [ion binding]; other site 1138382004931 active-site loop [active] 1138382004932 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1138382004933 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138382004934 substrate binding site [chemical binding]; other site 1138382004935 dimer interface [polypeptide binding]; other site 1138382004936 ATP binding site [chemical binding]; other site 1138382004937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138382004938 dimerization interface [polypeptide binding]; other site 1138382004939 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138382004940 cyclase homology domain; Region: CHD; cd07302 1138382004941 nucleotidyl binding site; other site 1138382004942 metal binding site [ion binding]; metal-binding site 1138382004943 dimer interface [polypeptide binding]; other site 1138382004944 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138382004945 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138382004946 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138382004947 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138382004948 ligand binding site [chemical binding]; other site 1138382004949 flexible hinge region; other site 1138382004950 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1138382004951 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1138382004952 putative catalytic cysteine [active] 1138382004953 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138382004954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382004955 Walker A motif; other site 1138382004956 ATP binding site [chemical binding]; other site 1138382004957 Walker B motif; other site 1138382004958 arginine finger; other site 1138382004959 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1138382004960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138382004961 metal ion-dependent adhesion site (MIDAS); other site 1138382004962 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1138382004963 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1138382004964 active site 1138382004965 (T/H)XGH motif; other site 1138382004966 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1138382004967 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382004968 catalytic core [active] 1138382004969 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138382004970 active site 1138382004971 catalytic triad [active] 1138382004972 oxyanion hole [active] 1138382004973 EDD domain protein, DegV family; Region: DegV; TIGR00762 1138382004974 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1138382004975 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138382004976 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382004977 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382004978 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 1138382004979 acyl-CoA synthetase; Validated; Region: PRK05850 1138382004980 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138382004981 acyl-activating enzyme (AAE) consensus motif; other site 1138382004982 active site 1138382004983 PE-PPE domain; Region: PE-PPE; pfam08237 1138382004984 Transport protein; Region: actII; TIGR00833 1138382004985 Condensation domain; Region: Condensation; pfam00668 1138382004986 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382004987 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138382004988 active site 1138382004989 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138382004990 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382004991 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138382004992 KR domain; Region: KR; pfam08659 1138382004993 putative NADP binding site [chemical binding]; other site 1138382004994 active site 1138382004995 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382004996 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382004997 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382004998 active site 1138382004999 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382005000 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138382005001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382005002 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138382005003 Enoylreductase; Region: PKS_ER; smart00829 1138382005004 NAD(P) binding site [chemical binding]; other site 1138382005005 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138382005006 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382005007 putative NADP binding site [chemical binding]; other site 1138382005008 active site 1138382005009 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382005010 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382005011 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138382005012 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382005013 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382005014 active site 1138382005015 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138382005016 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138382005017 FAD binding site [chemical binding]; other site 1138382005018 substrate binding site [chemical binding]; other site 1138382005019 catalytic base [active] 1138382005020 comEA protein; Region: comE; TIGR01259 1138382005021 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138382005022 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1138382005023 Competence protein; Region: Competence; pfam03772 1138382005024 hypothetical protein; Reviewed; Region: PRK07914 1138382005025 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1138382005026 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1138382005027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138382005028 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138382005029 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138382005030 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138382005031 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138382005032 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138382005033 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138382005034 DoxX-like family; Region: DoxX_2; pfam13564 1138382005035 ribonuclease Z; Reviewed; Region: PRK00055 1138382005036 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1138382005037 FOG: CBS domain [General function prediction only]; Region: COG0517 1138382005038 PemK-like protein; Region: PemK; pfam02452 1138382005039 GTP-binding protein LepA; Provisional; Region: PRK05433 1138382005040 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1138382005041 putative GEF interaction site [polypeptide binding]; other site 1138382005042 Switch I region; other site 1138382005043 G2 box; other site 1138382005044 G3 box; other site 1138382005045 Switch II region; other site 1138382005046 GTP/Mg2+ binding site [chemical binding]; other site 1138382005047 G4 box; other site 1138382005048 G5 box; other site 1138382005049 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1138382005050 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1138382005051 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1138382005052 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382005053 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382005054 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138382005055 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1138382005056 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138382005057 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1138382005058 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138382005059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382005060 dimer interface [polypeptide binding]; other site 1138382005061 conserved gate region; other site 1138382005062 putative PBP binding loops; other site 1138382005063 ABC-ATPase subunit interface; other site 1138382005064 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138382005065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382005066 dimer interface [polypeptide binding]; other site 1138382005067 conserved gate region; other site 1138382005068 putative PBP binding loops; other site 1138382005069 ABC-ATPase subunit interface; other site 1138382005070 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1138382005071 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1138382005072 Walker A/P-loop; other site 1138382005073 ATP binding site [chemical binding]; other site 1138382005074 Q-loop/lid; other site 1138382005075 ABC transporter signature motif; other site 1138382005076 Walker B; other site 1138382005077 D-loop; other site 1138382005078 H-loop/switch region; other site 1138382005079 TOBE domain; Region: TOBE; pfam03459 1138382005080 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1138382005081 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138382005082 Active Sites [active] 1138382005083 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1138382005084 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138382005085 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138382005086 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1138382005087 HemN C-terminal domain; Region: HemN_C; pfam06969 1138382005088 Predicted permease [General function prediction only]; Region: COG3329 1138382005089 salicylate synthase MbtI; Reviewed; Region: PRK07912 1138382005090 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138382005091 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1138382005092 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138382005093 DNA binding residues [nucleotide binding] 1138382005094 putative dimer interface [polypeptide binding]; other site 1138382005095 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382005096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382005097 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1138382005098 classical (c) SDRs; Region: SDR_c; cd05233 1138382005099 NAD(P) binding site [chemical binding]; other site 1138382005100 active site 1138382005101 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138382005102 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138382005103 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382005104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382005105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382005106 S-adenosylmethionine binding site [chemical binding]; other site 1138382005107 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382005108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382005109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382005110 S-adenosylmethionine binding site [chemical binding]; other site 1138382005111 Helix-turn-helix domain; Region: HTH_31; pfam13560 1138382005112 salt bridge; other site 1138382005113 non-specific DNA binding site [nucleotide binding]; other site 1138382005114 sequence-specific DNA binding site [nucleotide binding]; other site 1138382005115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382005116 S-adenosylmethionine binding site [chemical binding]; other site 1138382005117 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138382005118 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382005119 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138382005120 Cupin domain; Region: Cupin_2; pfam07883 1138382005121 choline dehydrogenase; Validated; Region: PRK02106 1138382005122 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138382005123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005125 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382005126 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382005127 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382005128 thiolase; Provisional; Region: PRK06158 1138382005129 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382005130 active site 1138382005131 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382005132 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382005133 NAD binding site [chemical binding]; other site 1138382005134 catalytic Zn binding site [ion binding]; other site 1138382005135 substrate binding site [chemical binding]; other site 1138382005136 structural Zn binding site [ion binding]; other site 1138382005137 short chain dehydrogenase; Provisional; Region: PRK07775 1138382005138 classical (c) SDRs; Region: SDR_c; cd05233 1138382005139 NAD(P) binding site [chemical binding]; other site 1138382005140 active site 1138382005141 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382005142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005144 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005145 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138382005146 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138382005147 ligand binding site [chemical binding]; other site 1138382005148 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005149 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382005150 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005151 Cytochrome P450; Region: p450; cl12078 1138382005152 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005153 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382005154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382005155 NAD(P) binding site [chemical binding]; other site 1138382005156 active site 1138382005157 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138382005158 classical (c) SDRs; Region: SDR_c; cd05233 1138382005159 NAD(P) binding site [chemical binding]; other site 1138382005160 active site 1138382005161 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382005162 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005163 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382005164 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005165 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1138382005166 short chain dehydrogenase; Provisional; Region: PRK07814 1138382005167 classical (c) SDRs; Region: SDR_c; cd05233 1138382005168 NAD(P) binding site [chemical binding]; other site 1138382005169 active site 1138382005170 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382005171 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382005172 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382005173 acyl-activating enzyme (AAE) consensus motif; other site 1138382005174 acyl-activating enzyme (AAE) consensus motif; other site 1138382005175 AMP binding site [chemical binding]; other site 1138382005176 active site 1138382005177 CoA binding site [chemical binding]; other site 1138382005178 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138382005179 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382005180 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382005181 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005182 Cytochrome P450; Region: p450; cl12078 1138382005183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005185 lipid-transfer protein; Provisional; Region: PRK07855 1138382005186 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382005187 active site 1138382005188 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138382005189 putative active site [active] 1138382005190 putative catalytic site [active] 1138382005191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005193 active site 1138382005194 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382005195 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382005196 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382005197 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138382005198 active site 1138382005199 catalytic site [active] 1138382005200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005202 active site 1138382005203 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005204 Cytochrome P450; Region: p450; cl12078 1138382005205 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382005206 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138382005207 NAD binding site [chemical binding]; other site 1138382005208 catalytic residues [active] 1138382005209 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382005210 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382005211 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382005212 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382005213 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138382005214 putative active site [active] 1138382005215 putative catalytic site [active] 1138382005216 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382005217 Isochorismatase family; Region: Isochorismatase; pfam00857 1138382005218 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138382005219 catalytic triad [active] 1138382005220 conserved cis-peptide bond; other site 1138382005221 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382005222 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138382005223 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382005224 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382005225 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138382005226 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382005227 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382005228 active site 1138382005229 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382005230 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382005231 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005232 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005235 active site 1138382005236 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1138382005237 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138382005238 acyl-activating enzyme (AAE) consensus motif; other site 1138382005239 putative AMP binding site [chemical binding]; other site 1138382005240 putative active site [active] 1138382005241 putative CoA binding site [chemical binding]; other site 1138382005242 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382005243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138382005244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382005245 NAD(P) binding site [chemical binding]; other site 1138382005246 active site 1138382005247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382005248 active site 1138382005249 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382005250 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382005251 acyl-activating enzyme (AAE) consensus motif; other site 1138382005252 AMP binding site [chemical binding]; other site 1138382005253 active site 1138382005254 CoA binding site [chemical binding]; other site 1138382005255 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382005256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382005257 substrate binding site [chemical binding]; other site 1138382005258 oxyanion hole (OAH) forming residues; other site 1138382005259 trimer interface [polypeptide binding]; other site 1138382005260 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382005261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382005262 substrate binding site [chemical binding]; other site 1138382005263 oxyanion hole (OAH) forming residues; other site 1138382005264 trimer interface [polypeptide binding]; other site 1138382005265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005267 active site 1138382005268 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382005269 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382005270 substrate binding site [chemical binding]; other site 1138382005271 oxyanion hole (OAH) forming residues; other site 1138382005272 trimer interface [polypeptide binding]; other site 1138382005273 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382005274 active site 2 [active] 1138382005275 active site 1 [active] 1138382005276 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138382005277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382005278 substrate binding site [chemical binding]; other site 1138382005279 oxyanion hole (OAH) forming residues; other site 1138382005280 trimer interface [polypeptide binding]; other site 1138382005281 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1138382005282 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138382005283 NAD binding site [chemical binding]; other site 1138382005284 homodimer interface [polypeptide binding]; other site 1138382005285 active site 1138382005286 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382005287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382005288 acyl-activating enzyme (AAE) consensus motif; other site 1138382005289 AMP binding site [chemical binding]; other site 1138382005290 active site 1138382005291 CoA binding site [chemical binding]; other site 1138382005292 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382005293 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382005294 thiolase; Provisional; Region: PRK06158 1138382005295 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382005296 active site 1138382005297 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138382005298 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138382005299 active site 1138382005300 iron coordination sites [ion binding]; other site 1138382005301 substrate binding pocket [chemical binding]; other site 1138382005302 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1138382005303 glycerate dehydrogenase; Provisional; Region: PRK06487 1138382005304 ligand binding site [chemical binding]; other site 1138382005305 NAD binding site [chemical binding]; other site 1138382005306 dimerization interface [polypeptide binding]; other site 1138382005307 catalytic site [active] 1138382005308 enoyl-CoA hydratase; Provisional; Region: PRK06494 1138382005309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382005310 substrate binding site [chemical binding]; other site 1138382005311 oxyanion hole (OAH) forming residues; other site 1138382005312 trimer interface [polypeptide binding]; other site 1138382005313 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382005314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005316 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005317 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005318 active site 1138382005319 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382005320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005321 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005322 active site 1138382005323 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382005324 CoenzymeA binding site [chemical binding]; other site 1138382005325 subunit interaction site [polypeptide binding]; other site 1138382005326 PHB binding site; other site 1138382005327 enoyl-CoA hydratase; Provisional; Region: PRK08290 1138382005328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382005329 substrate binding site [chemical binding]; other site 1138382005330 oxyanion hole (OAH) forming residues; other site 1138382005331 trimer interface [polypeptide binding]; other site 1138382005332 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005333 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382005334 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138382005335 FMN binding site [chemical binding]; other site 1138382005336 dimer interface [polypeptide binding]; other site 1138382005337 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382005338 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382005339 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138382005340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382005341 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382005342 acyl-activating enzyme (AAE) consensus motif; other site 1138382005343 putative AMP binding site [chemical binding]; other site 1138382005344 putative active site [active] 1138382005345 putative CoA binding site [chemical binding]; other site 1138382005346 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005347 Cytochrome P450; Region: p450; cl12078 1138382005348 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138382005349 FMN binding site [chemical binding]; other site 1138382005350 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382005351 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382005352 MarR family; Region: MarR_2; pfam12802 1138382005353 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138382005354 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1138382005355 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1138382005356 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138382005357 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1138382005358 OsmC-like protein; Region: OsmC; cl00767 1138382005359 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138382005360 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1138382005361 active site pocket [active] 1138382005362 aconitate hydratase; Validated; Region: PRK09277 1138382005363 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138382005364 substrate binding site [chemical binding]; other site 1138382005365 ligand binding site [chemical binding]; other site 1138382005366 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1138382005367 substrate binding site [chemical binding]; other site 1138382005368 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138382005369 HTH domain; Region: HTH_11; cl17392 1138382005370 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138382005371 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1138382005372 heme-binding site [chemical binding]; other site 1138382005373 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1138382005374 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382005375 catalytic loop [active] 1138382005376 iron binding site [ion binding]; other site 1138382005377 Cupin domain; Region: Cupin_2; cl17218 1138382005378 Ferredoxin [Energy production and conversion]; Region: COG1146 1138382005379 4Fe-4S binding domain; Region: Fer4; pfam00037 1138382005380 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138382005381 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138382005382 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138382005383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382005384 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138382005385 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1138382005386 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138382005387 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138382005388 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138382005389 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138382005390 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138382005391 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1138382005392 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1138382005393 Binuclear center (active site) [active] 1138382005394 K-pathway; other site 1138382005395 Putative proton exit pathway; other site 1138382005396 Hemerythrin-like domain; Region: Hr-like; cd12108 1138382005397 Fe binding site [ion binding]; other site 1138382005398 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382005399 PPE family; Region: PPE; pfam00823 1138382005400 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382005401 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382005402 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138382005403 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382005404 Condensation domain; Region: Condensation; pfam00668 1138382005405 malate dehydrogenase; Provisional; Region: PRK13529 1138382005406 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1138382005407 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1138382005408 NAD(P) binding site [chemical binding]; other site 1138382005409 Flavodoxin; Region: Flavodoxin_1; pfam00258 1138382005410 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1138382005411 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1138382005412 FAD binding pocket [chemical binding]; other site 1138382005413 FAD binding motif [chemical binding]; other site 1138382005414 catalytic residues [active] 1138382005415 NAD binding pocket [chemical binding]; other site 1138382005416 phosphate binding motif [ion binding]; other site 1138382005417 beta-alpha-beta structure motif; other site 1138382005418 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138382005419 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382005420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005421 Cupin domain; Region: Cupin_2; cl17218 1138382005422 short chain dehydrogenase; Provisional; Region: PRK07577 1138382005423 classical (c) SDRs; Region: SDR_c; cd05233 1138382005424 NAD(P) binding site [chemical binding]; other site 1138382005425 active site 1138382005426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138382005427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382005428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138382005429 dimerization interface [polypeptide binding]; other site 1138382005430 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1138382005431 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1138382005432 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1138382005433 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1138382005434 acyl-activating enzyme (AAE) consensus motif; other site 1138382005435 active site 1138382005436 AMP binding site [chemical binding]; other site 1138382005437 substrate binding site [chemical binding]; other site 1138382005438 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1138382005439 Condensation domain; Region: Condensation; pfam00668 1138382005440 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382005441 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1138382005442 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1138382005443 acyl-activating enzyme (AAE) consensus motif; other site 1138382005444 AMP binding site [chemical binding]; other site 1138382005445 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382005446 Thioesterase domain; Region: Thioesterase; pfam00975 1138382005447 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382005448 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138382005449 active site 1138382005450 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138382005451 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382005452 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1138382005453 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382005454 NADP binding site [chemical binding]; other site 1138382005455 active site 1138382005456 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382005457 Condensation domain; Region: Condensation; pfam00668 1138382005458 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382005459 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382005460 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382005461 acyl-activating enzyme (AAE) consensus motif; other site 1138382005462 AMP binding site [chemical binding]; other site 1138382005463 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382005464 Condensation domain; Region: Condensation; pfam00668 1138382005465 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382005466 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382005467 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382005468 acyl-activating enzyme (AAE) consensus motif; other site 1138382005469 AMP binding site [chemical binding]; other site 1138382005470 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382005471 Condensation domain; Region: Condensation; pfam00668 1138382005472 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382005473 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382005474 acyl-activating enzyme (AAE) consensus motif; other site 1138382005475 AMP binding site [chemical binding]; other site 1138382005476 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382005477 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1138382005478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382005479 MbtH-like protein; Region: MbtH; pfam03621 1138382005480 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1138382005481 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138382005482 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382005483 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382005484 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382005485 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138382005486 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1138382005487 HTH domain; Region: HTH_11; cl17392 1138382005488 chaperone protein DnaJ; Provisional; Region: PRK14278 1138382005489 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138382005490 HSP70 interaction site [polypeptide binding]; other site 1138382005491 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138382005492 Zn binding sites [ion binding]; other site 1138382005493 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138382005494 dimer interface [polypeptide binding]; other site 1138382005495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1138382005496 RNA methyltransferase, RsmE family; Region: TIGR00046 1138382005497 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1138382005498 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1138382005499 PhoH-like protein; Region: PhoH; pfam02562 1138382005500 metal-binding heat shock protein; Provisional; Region: PRK00016 1138382005501 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138382005502 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138382005503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138382005504 Transporter associated domain; Region: CorC_HlyC; smart01091 1138382005505 GTPase Era; Reviewed; Region: era; PRK00089 1138382005506 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1138382005507 G1 box; other site 1138382005508 GTP/Mg2+ binding site [chemical binding]; other site 1138382005509 Switch I region; other site 1138382005510 G2 box; other site 1138382005511 Switch II region; other site 1138382005512 G3 box; other site 1138382005513 G4 box; other site 1138382005514 G5 box; other site 1138382005515 KH domain; Region: KH_2; pfam07650 1138382005516 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1138382005517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382005518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382005519 catalytic residue [active] 1138382005520 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1138382005521 amidase; Provisional; Region: PRK06061 1138382005522 Amidase; Region: Amidase; pfam01425 1138382005523 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1138382005524 Recombination protein O N terminal; Region: RecO_N; pfam11967 1138382005525 Recombination protein O C terminal; Region: RecO_C; pfam02565 1138382005526 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138382005527 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138382005528 catalytic residue [active] 1138382005529 putative FPP diphosphate binding site; other site 1138382005530 putative FPP binding hydrophobic cleft; other site 1138382005531 dimer interface [polypeptide binding]; other site 1138382005532 putative IPP diphosphate binding site; other site 1138382005533 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138382005534 metal binding site 2 [ion binding]; metal-binding site 1138382005535 putative DNA binding helix; other site 1138382005536 metal binding site 1 [ion binding]; metal-binding site 1138382005537 dimer interface [polypeptide binding]; other site 1138382005538 structural Zn2+ binding site [ion binding]; other site 1138382005539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382005540 dimerization interface [polypeptide binding]; other site 1138382005541 putative DNA binding site [nucleotide binding]; other site 1138382005542 putative Zn2+ binding site [ion binding]; other site 1138382005543 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1138382005544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138382005545 motif 1; other site 1138382005546 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1138382005547 active site 1138382005548 motif 2; other site 1138382005549 motif 3; other site 1138382005550 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1138382005551 anticodon binding site; other site 1138382005552 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382005553 PPE family; Region: PPE; pfam00823 1138382005554 Repair protein; Region: Repair_PSII; pfam04536 1138382005555 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1138382005556 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1138382005557 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1138382005558 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1138382005559 E-class dimer interface [polypeptide binding]; other site 1138382005560 P-class dimer interface [polypeptide binding]; other site 1138382005561 active site 1138382005562 Cu2+ binding site [ion binding]; other site 1138382005563 Zn2+ binding site [ion binding]; other site 1138382005564 DNA primase; Validated; Region: dnaG; PRK05667 1138382005565 CHC2 zinc finger; Region: zf-CHC2; cl17510 1138382005566 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1138382005567 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1138382005568 active site 1138382005569 metal binding site [ion binding]; metal-binding site 1138382005570 interdomain interaction site; other site 1138382005571 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1138382005572 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1138382005573 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138382005574 active site 1138382005575 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138382005576 non-prolyl cis peptide bond; other site 1138382005577 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1138382005578 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382005579 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382005580 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382005581 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1138382005582 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1138382005583 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1138382005584 trimer interface [polypeptide binding]; other site 1138382005585 active site 1138382005586 substrate binding site [chemical binding]; other site 1138382005587 CoA binding site [chemical binding]; other site 1138382005588 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138382005589 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138382005590 dimer interface [polypeptide binding]; other site 1138382005591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382005592 catalytic residue [active] 1138382005593 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1138382005594 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1138382005595 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1138382005596 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1138382005597 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1138382005598 [4Fe-4S] binding site [ion binding]; other site 1138382005599 molybdopterin cofactor binding site; other site 1138382005600 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1138382005601 molybdopterin cofactor binding site; other site 1138382005602 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1138382005603 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1138382005604 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1138382005605 FAD binding pocket [chemical binding]; other site 1138382005606 FAD binding motif [chemical binding]; other site 1138382005607 catalytic residues [active] 1138382005608 NAD binding pocket [chemical binding]; other site 1138382005609 phosphate binding motif [ion binding]; other site 1138382005610 beta-alpha-beta structure motif; other site 1138382005611 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138382005612 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005613 active site 1138382005614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382005615 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138382005616 Walker A/P-loop; other site 1138382005617 ATP binding site [chemical binding]; other site 1138382005618 Q-loop/lid; other site 1138382005619 ABC transporter signature motif; other site 1138382005620 Walker B; other site 1138382005621 D-loop; other site 1138382005622 H-loop/switch region; other site 1138382005623 MarR family; Region: MarR; pfam01047 1138382005624 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382005625 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 1138382005626 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644 1138382005627 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138382005628 Walker A/P-loop; other site 1138382005629 ATP binding site [chemical binding]; other site 1138382005630 Q-loop/lid; other site 1138382005631 ABC transporter signature motif; other site 1138382005632 Walker B; other site 1138382005633 D-loop; other site 1138382005634 H-loop/switch region; other site 1138382005635 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138382005636 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138382005637 Walker A/P-loop; other site 1138382005638 ATP binding site [chemical binding]; other site 1138382005639 Q-loop/lid; other site 1138382005640 ABC transporter signature motif; other site 1138382005641 Walker B; other site 1138382005642 D-loop; other site 1138382005643 H-loop/switch region; other site 1138382005644 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1138382005645 amino acid transporter; Region: 2A0306; TIGR00909 1138382005646 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138382005647 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138382005648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138382005649 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138382005650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382005651 dimer interface [polypeptide binding]; other site 1138382005652 conserved gate region; other site 1138382005653 putative PBP binding loops; other site 1138382005654 ABC-ATPase subunit interface; other site 1138382005655 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1138382005656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382005657 dimer interface [polypeptide binding]; other site 1138382005658 conserved gate region; other site 1138382005659 putative PBP binding loops; other site 1138382005660 ABC-ATPase subunit interface; other site 1138382005661 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138382005662 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138382005663 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382005664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382005665 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138382005666 catalytic site [active] 1138382005667 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1138382005668 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138382005669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382005670 ABC transporter signature motif; other site 1138382005671 Walker B; other site 1138382005672 D-loop; other site 1138382005673 H-loop/switch region; other site 1138382005674 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1138382005675 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382005676 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382005677 NAD(P) binding site [chemical binding]; other site 1138382005678 catalytic residues [active] 1138382005679 Repair protein; Region: Repair_PSII; pfam04536 1138382005680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1138382005681 AAA domain; Region: AAA_33; pfam13671 1138382005682 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1138382005683 active site 1138382005684 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1138382005685 catalytic triad [active] 1138382005686 active site nucleophile [active] 1138382005687 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1138382005688 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1138382005689 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382005690 cyclase homology domain; Region: CHD; cd07302 1138382005691 nucleotidyl binding site; other site 1138382005692 metal binding site [ion binding]; metal-binding site 1138382005693 dimer interface [polypeptide binding]; other site 1138382005694 AAA ATPase domain; Region: AAA_16; pfam13191 1138382005695 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138382005696 GAF domain; Region: GAF; pfam01590 1138382005697 GAF domain; Region: GAF_3; pfam13492 1138382005698 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138382005699 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138382005700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138382005701 ATP binding site [chemical binding]; other site 1138382005702 Mg2+ binding site [ion binding]; other site 1138382005703 G-X-G motif; other site 1138382005704 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382005705 anti sigma factor interaction site; other site 1138382005706 regulatory phosphorylation site [posttranslational modification]; other site 1138382005707 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382005708 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382005709 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382005710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382005711 S-adenosylmethionine binding site [chemical binding]; other site 1138382005712 CCC1-related family of proteins; Region: CCC1_like; cl00278 1138382005713 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138382005714 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382005715 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138382005716 acyl-activating enzyme (AAE) consensus motif; other site 1138382005717 putative AMP binding site [chemical binding]; other site 1138382005718 putative active site [active] 1138382005719 putative CoA binding site [chemical binding]; other site 1138382005720 TIGR03085 family protein; Region: TIGR03085 1138382005721 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382005722 heat shock protein 90; Provisional; Region: PRK05218 1138382005723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382005724 ATP binding site [chemical binding]; other site 1138382005725 Mg2+ binding site [ion binding]; other site 1138382005726 G-X-G motif; other site 1138382005727 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382005728 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382005729 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382005730 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1138382005731 dimer interface [polypeptide binding]; other site 1138382005732 ligand binding site [chemical binding]; other site 1138382005733 Predicted membrane protein [Function unknown]; Region: COG4270 1138382005734 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382005735 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382005736 NAD binding site [chemical binding]; other site 1138382005737 catalytic Zn binding site [ion binding]; other site 1138382005738 substrate binding site [chemical binding]; other site 1138382005739 structural Zn binding site [ion binding]; other site 1138382005740 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382005741 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1138382005742 dimer interface [polypeptide binding]; other site 1138382005743 active site 1138382005744 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138382005745 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138382005746 active site 1138382005747 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138382005748 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138382005749 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138382005750 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138382005751 DoxX-like family; Region: DoxX_2; pfam13564 1138382005752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382005753 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138382005754 NAD(P) binding site [chemical binding]; other site 1138382005755 active site 1138382005756 haloalkane dehalogenase; Provisional; Region: PRK00870 1138382005757 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1138382005758 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1138382005759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382005760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382005761 homodimer interface [polypeptide binding]; other site 1138382005762 catalytic residue [active] 1138382005763 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005764 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382005765 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005766 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382005767 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382005768 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138382005769 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138382005770 ligand binding site [chemical binding]; other site 1138382005771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005774 Cytochrome P450; Region: p450; cl12078 1138382005775 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382005776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382005777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382005778 dimerization interface [polypeptide binding]; other site 1138382005779 putative DNA binding site [nucleotide binding]; other site 1138382005780 putative Zn2+ binding site [ion binding]; other site 1138382005781 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1138382005782 arsenical-resistance protein; Region: acr3; TIGR00832 1138382005783 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1138382005784 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138382005785 active site 1138382005786 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1138382005787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382005788 putative metal binding site [ion binding]; other site 1138382005789 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382005790 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382005791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005792 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005793 Cytochrome P450; Region: p450; cl12078 1138382005794 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138382005795 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138382005796 active site residue [active] 1138382005797 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138382005798 active site residue [active] 1138382005799 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382005800 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138382005801 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138382005802 hypothetical protein; Provisional; Region: PRK08244 1138382005803 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382005804 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382005805 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382005806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005807 Predicted ATPase [General function prediction only]; Region: COG4637 1138382005808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382005809 Walker A/P-loop; other site 1138382005810 ATP binding site [chemical binding]; other site 1138382005811 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1138382005812 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1138382005813 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138382005814 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382005815 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382005816 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1138382005817 4Fe-4S binding domain; Region: Fer4; cl02805 1138382005818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138382005819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382005820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1138382005821 dimerization interface [polypeptide binding]; other site 1138382005822 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138382005823 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138382005824 putative active site [active] 1138382005825 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1138382005826 putative active site [active] 1138382005827 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1138382005828 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138382005829 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138382005830 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138382005831 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382005832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382005833 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005834 Cytochrome P450; Region: p450; cl12078 1138382005835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005839 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138382005840 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382005841 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138382005842 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382005843 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138382005844 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382005845 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382005846 active site 1138382005847 ATP binding site [chemical binding]; other site 1138382005848 substrate binding site [chemical binding]; other site 1138382005849 activation loop (A-loop); other site 1138382005850 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138382005851 2TM domain; Region: 2TM; pfam13239 1138382005852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005853 WHG domain; Region: WHG; pfam13305 1138382005854 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005855 Cytochrome P450; Region: p450; cl12078 1138382005856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382005857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382005858 active site 1138382005859 metal binding site [ion binding]; metal-binding site 1138382005860 Z1 domain; Region: Z1; pfam10593 1138382005861 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138382005862 putative active site [active] 1138382005863 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1138382005864 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1138382005865 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1138382005866 cofactor binding site; other site 1138382005867 DNA binding site [nucleotide binding] 1138382005868 substrate interaction site [chemical binding]; other site 1138382005869 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1138382005870 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1138382005871 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382005872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382005873 active site 1138382005874 ATP binding site [chemical binding]; other site 1138382005875 substrate binding site [chemical binding]; other site 1138382005876 activation loop (A-loop); other site 1138382005877 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382005878 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382005879 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382005880 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382005881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005883 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382005884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382005885 active site 1138382005886 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138382005887 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138382005888 active site 1138382005889 metal binding site [ion binding]; metal-binding site 1138382005890 Cutinase; Region: Cutinase; pfam01083 1138382005891 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382005892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382005893 Septum formation; Region: Septum_form; pfam13845 1138382005894 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382005895 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382005896 Cytochrome P450; Region: p450; cl12078 1138382005897 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382005898 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382005899 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382005900 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382005901 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1138382005902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382005903 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1138382005904 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382005905 NAD binding site [chemical binding]; other site 1138382005906 catalytic Zn binding site [ion binding]; other site 1138382005907 substrate binding site [chemical binding]; other site 1138382005908 structural Zn binding site [ion binding]; other site 1138382005909 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382005910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382005911 S-adenosylmethionine binding site [chemical binding]; other site 1138382005912 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382005913 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382005914 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1138382005915 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1138382005916 diacylglycerol kinase; Reviewed; Region: PRK11914 1138382005917 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138382005918 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138382005919 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382005920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382005921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382005922 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1138382005923 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138382005924 nucleoside/Zn binding site; other site 1138382005925 dimer interface [polypeptide binding]; other site 1138382005926 catalytic motif [active] 1138382005927 hypothetical protein; Provisional; Region: PRK06126 1138382005928 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382005929 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138382005930 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138382005931 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382005932 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138382005933 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138382005934 dimer interface [polypeptide binding]; other site 1138382005935 active site 1138382005936 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138382005937 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138382005938 dimer interface [polypeptide binding]; other site 1138382005939 active site 1138382005940 acyl carrier protein; Provisional; Region: acpP; PRK00982 1138382005941 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138382005942 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138382005943 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138382005944 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138382005945 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1138382005946 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1138382005947 dimer interface [polypeptide binding]; other site 1138382005948 TPP-binding site [chemical binding]; other site 1138382005949 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1138382005950 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138382005951 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1138382005952 dimer interface [polypeptide binding]; other site 1138382005953 catalytic triad [active] 1138382005954 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1138382005955 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1138382005956 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382005957 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138382005958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382005959 active site 1138382005960 metal binding site [ion binding]; metal-binding site 1138382005961 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1138382005962 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1138382005963 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138382005964 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1138382005965 active site 1138382005966 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1138382005967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382005968 motif II; other site 1138382005969 hypothetical protein; Provisional; Region: PRK07908 1138382005970 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382005971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382005972 catalytic residue [active] 1138382005973 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1138382005974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1138382005975 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1138382005976 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1138382005977 Putative zinc ribbon domain; Region: DUF164; pfam02591 1138382005978 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1138382005979 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1138382005980 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138382005981 active site 1138382005982 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382005983 catalytic core [active] 1138382005984 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1138382005985 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382005986 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138382005987 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382005988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382005989 sequence-specific DNA binding site [nucleotide binding]; other site 1138382005990 salt bridge; other site 1138382005991 Cupin domain; Region: Cupin_2; pfam07883 1138382005992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382005993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382005994 S-adenosylmethionine binding site [chemical binding]; other site 1138382005995 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1138382005996 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1138382005997 putative active site; other site 1138382005998 putative metal binding residues [ion binding]; other site 1138382005999 signature motif; other site 1138382006000 putative triphosphate binding site [ion binding]; other site 1138382006001 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1138382006002 hypothetical protein; Provisional; Region: PRK06185 1138382006003 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1138382006004 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1138382006005 oligomerization interface [polypeptide binding]; other site 1138382006006 active site 1138382006007 metal binding site [ion binding]; metal-binding site 1138382006008 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138382006009 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138382006010 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138382006011 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138382006012 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138382006013 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138382006014 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138382006015 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1138382006016 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138382006017 metal binding triad; other site 1138382006018 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138382006019 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138382006020 metal binding triad; other site 1138382006021 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138382006022 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382006023 CoenzymeA binding site [chemical binding]; other site 1138382006024 subunit interaction site [polypeptide binding]; other site 1138382006025 PHB binding site; other site 1138382006026 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382006027 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382006028 MarR family; Region: MarR_2; pfam12802 1138382006029 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1138382006030 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138382006031 NAD binding site [chemical binding]; other site 1138382006032 substrate binding site [chemical binding]; other site 1138382006033 putative active site [active] 1138382006034 glutamine synthetase, type I; Region: GlnA; TIGR00653 1138382006035 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138382006036 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138382006037 RDD family; Region: RDD; pfam06271 1138382006038 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1138382006039 lipoyl synthase; Provisional; Region: PRK05481 1138382006040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382006041 FeS/SAM binding site; other site 1138382006042 lipoate-protein ligase B; Provisional; Region: PRK14345 1138382006043 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1138382006044 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1138382006045 putative NAD(P) binding site [chemical binding]; other site 1138382006046 putative active site [active] 1138382006047 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138382006048 E3 interaction surface; other site 1138382006049 lipoyl attachment site [posttranslational modification]; other site 1138382006050 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138382006051 E3 interaction surface; other site 1138382006052 lipoyl attachment site [posttranslational modification]; other site 1138382006053 e3 binding domain; Region: E3_binding; pfam02817 1138382006054 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1138382006055 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138382006056 short chain dehydrogenase; Validated; Region: PRK05855 1138382006057 classical (c) SDRs; Region: SDR_c; cd05233 1138382006058 NAD(P) binding site [chemical binding]; other site 1138382006059 active site 1138382006060 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382006061 hydrophobic ligand binding site; other site 1138382006062 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138382006063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382006064 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1138382006065 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1138382006066 interface (dimer of trimers) [polypeptide binding]; other site 1138382006067 Substrate-binding/catalytic site; other site 1138382006068 Zn-binding sites [ion binding]; other site 1138382006069 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1138382006070 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1138382006071 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1138382006072 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1138382006073 homodimer interface [polypeptide binding]; other site 1138382006074 substrate-cofactor binding pocket; other site 1138382006075 catalytic residue [active] 1138382006076 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1138382006077 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1138382006078 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1138382006079 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1138382006080 putative dimer interface [polypeptide binding]; other site 1138382006081 active site pocket [active] 1138382006082 putative cataytic base [active] 1138382006083 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1138382006084 homotrimer interface [polypeptide binding]; other site 1138382006085 Walker A motif; other site 1138382006086 GTP binding site [chemical binding]; other site 1138382006087 Walker B motif; other site 1138382006088 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1138382006089 Glycerate kinase family; Region: Gly_kinase; pfam02595 1138382006090 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1138382006091 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1138382006092 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138382006093 substrate binding site [chemical binding]; other site 1138382006094 ATP binding site [chemical binding]; other site 1138382006095 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1138382006096 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1138382006097 active site 1138382006098 dimer interface [polypeptide binding]; other site 1138382006099 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1138382006100 Ligand Binding Site [chemical binding]; other site 1138382006101 Molecular Tunnel; other site 1138382006102 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1138382006103 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1138382006104 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1138382006105 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382006106 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1138382006107 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1138382006108 heme bH binding site [chemical binding]; other site 1138382006109 intrachain domain interface; other site 1138382006110 heme bL binding site [chemical binding]; other site 1138382006111 interchain domain interface [polypeptide binding]; other site 1138382006112 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1138382006113 Qo binding site; other site 1138382006114 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1138382006115 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138382006116 iron-sulfur cluster [ion binding]; other site 1138382006117 [2Fe-2S] cluster binding site [ion binding]; other site 1138382006118 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1138382006119 Cytochrome c; Region: Cytochrom_C; pfam00034 1138382006120 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1138382006121 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1138382006122 Subunit I/III interface [polypeptide binding]; other site 1138382006123 hypothetical protein; Validated; Region: PRK07883 1138382006124 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138382006125 active site 1138382006126 catalytic site [active] 1138382006127 substrate binding site [chemical binding]; other site 1138382006128 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138382006129 GIY-YIG motif/motif A; other site 1138382006130 active site 1138382006131 catalytic site [active] 1138382006132 putative DNA binding site [nucleotide binding]; other site 1138382006133 metal binding site [ion binding]; metal-binding site 1138382006134 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138382006135 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138382006136 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1138382006137 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382006138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382006139 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138382006140 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138382006141 acyl-activating enzyme (AAE) consensus motif; other site 1138382006142 putative AMP binding site [chemical binding]; other site 1138382006143 putative active site [active] 1138382006144 putative CoA binding site [chemical binding]; other site 1138382006145 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138382006146 putative hydrophobic ligand binding site [chemical binding]; other site 1138382006147 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138382006148 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138382006149 DTAP/Switch II; other site 1138382006150 Switch I; other site 1138382006151 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382006152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138382006153 putative acyl-acceptor binding pocket; other site 1138382006154 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138382006155 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1138382006156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382006157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382006158 active site 1138382006159 ATP binding site [chemical binding]; other site 1138382006160 substrate binding site [chemical binding]; other site 1138382006161 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138382006162 substrate binding site [chemical binding]; other site 1138382006163 activation loop (A-loop); other site 1138382006164 activation loop (A-loop); other site 1138382006165 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138382006166 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138382006167 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138382006168 substrate binding pocket [chemical binding]; other site 1138382006169 chain length determination region; other site 1138382006170 substrate-Mg2+ binding site; other site 1138382006171 catalytic residues [active] 1138382006172 aspartate-rich region 1; other site 1138382006173 active site lid residues [active] 1138382006174 aspartate-rich region 2; other site 1138382006175 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1138382006176 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1138382006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1138382006178 MraZ protein; Region: MraZ; pfam02381 1138382006179 MraZ protein; Region: MraZ; pfam02381 1138382006180 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1138382006181 MraW methylase family; Region: Methyltransf_5; cl17771 1138382006182 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138382006183 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1138382006184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138382006185 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382006186 hypothetical protein; Validated; Region: PRK05868 1138382006187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382006188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006189 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1138382006190 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138382006191 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138382006192 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138382006193 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1138382006194 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138382006195 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138382006196 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1138382006197 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1138382006198 Mg++ binding site [ion binding]; other site 1138382006199 putative catalytic motif [active] 1138382006200 putative substrate binding site [chemical binding]; other site 1138382006201 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1138382006202 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138382006203 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138382006204 cell division protein FtsW; Region: ftsW; TIGR02614 1138382006205 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1138382006206 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1138382006207 active site 1138382006208 homodimer interface [polypeptide binding]; other site 1138382006209 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1138382006210 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138382006211 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138382006212 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138382006213 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1138382006214 Cell division protein FtsQ; Region: FtsQ; pfam03799 1138382006215 cell division protein FtsZ; Validated; Region: PRK09330 1138382006216 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1138382006217 nucleotide binding site [chemical binding]; other site 1138382006218 SulA interaction site; other site 1138382006219 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1138382006220 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1138382006221 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1138382006222 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138382006223 catalytic residue [active] 1138382006224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1138382006225 Predicted integral membrane protein [Function unknown]; Region: COG0762 1138382006226 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138382006227 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138382006228 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138382006229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382006230 active site 1138382006231 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382006232 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382006233 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382006234 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 1138382006235 NAD(P) binding site [chemical binding]; other site 1138382006236 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138382006237 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1138382006238 active site 1138382006239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382006240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006241 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382006242 CoenzymeA binding site [chemical binding]; other site 1138382006243 subunit interaction site [polypeptide binding]; other site 1138382006244 PHB binding site; other site 1138382006245 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382006246 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382006247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382006248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006249 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138382006250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382006251 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382006252 Cytochrome P450; Region: p450; cl12078 1138382006253 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138382006254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382006255 catalytic loop [active] 1138382006256 iron binding site [ion binding]; other site 1138382006257 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1138382006258 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138382006259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382006260 thiolase; Provisional; Region: PRK06158 1138382006261 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382006262 active site 1138382006263 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382006264 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382006265 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382006266 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382006267 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 1138382006268 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1138382006269 active site 2 [active] 1138382006270 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382006271 active site 2 [active] 1138382006272 active site 1 [active] 1138382006273 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1138382006274 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382006275 active site 2 [active] 1138382006276 active site 1 [active] 1138382006277 enoyl-CoA hydratase; Provisional; Region: PRK06494 1138382006278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382006279 substrate binding site [chemical binding]; other site 1138382006280 oxyanion hole (OAH) forming residues; other site 1138382006281 trimer interface [polypeptide binding]; other site 1138382006282 TIGR03084 family protein; Region: TIGR03084 1138382006283 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382006284 Wyosine base formation; Region: Wyosine_form; pfam08608 1138382006285 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1138382006286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382006287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006288 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138382006289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382006290 acyl-activating enzyme (AAE) consensus motif; other site 1138382006291 AMP binding site [chemical binding]; other site 1138382006292 active site 1138382006293 CoA binding site [chemical binding]; other site 1138382006294 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382006295 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382006296 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382006297 active site 1138382006298 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138382006299 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382006300 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382006301 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1138382006302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138382006303 carboxyltransferase (CT) interaction site; other site 1138382006304 biotinylation site [posttranslational modification]; other site 1138382006305 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1138382006306 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382006307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382006308 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138382006309 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138382006310 classical (c) SDRs; Region: SDR_c; cd05233 1138382006311 NAD(P) binding site [chemical binding]; other site 1138382006312 active site 1138382006313 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382006314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382006315 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382006316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382006317 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382006318 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382006319 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1138382006320 Cytochrome P450; Region: p450; cl12078 1138382006321 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138382006322 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138382006323 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1138382006324 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1138382006325 AMP-binding enzyme; Region: AMP-binding; pfam00501 1138382006326 dimer interface [polypeptide binding]; other site 1138382006327 acyl-activating enzyme (AAE) consensus motif; other site 1138382006328 putative active site [active] 1138382006329 AMP binding site [chemical binding]; other site 1138382006330 putative CoA binding site [chemical binding]; other site 1138382006331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382006332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382006333 active site 1138382006334 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1138382006335 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1138382006336 putative active site [active] 1138382006337 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1138382006338 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382006339 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382006340 NAD binding site [chemical binding]; other site 1138382006341 catalytic Zn binding site [ion binding]; other site 1138382006342 substrate binding site [chemical binding]; other site 1138382006343 structural Zn binding site [ion binding]; other site 1138382006344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382006345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382006346 active site 1138382006347 Integrase core domain; Region: rve; pfam00665 1138382006348 Integrase core domain; Region: rve_3; cl15866 1138382006349 putative transposase OrfB; Reviewed; Region: PHA02517 1138382006350 Integrase core domain; Region: rve; pfam00665 1138382006351 Integrase core domain; Region: rve_2; pfam13333 1138382006352 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 1138382006353 active site 1138382006354 nucleophile elbow; other site 1138382006355 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1138382006356 active site 1138382006357 NTP binding site [chemical binding]; other site 1138382006358 metal binding triad [ion binding]; metal-binding site 1138382006359 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 1138382006360 ThiF family; Region: ThiF; pfam00899 1138382006361 ATP binding site [chemical binding]; other site 1138382006362 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1138382006363 nudix motif; other site 1138382006364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382006365 non-specific DNA binding site [nucleotide binding]; other site 1138382006366 salt bridge; other site 1138382006367 sequence-specific DNA binding site [nucleotide binding]; other site 1138382006368 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382006369 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138382006370 hypothetical protein; Provisional; Region: PRK07906 1138382006371 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1138382006372 putative metal binding site [ion binding]; other site 1138382006373 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138382006374 substrate binding site [chemical binding]; other site 1138382006375 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1138382006376 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1138382006377 quinone interaction residues [chemical binding]; other site 1138382006378 active site 1138382006379 catalytic residues [active] 1138382006380 FMN binding site [chemical binding]; other site 1138382006381 substrate binding site [chemical binding]; other site 1138382006382 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382006383 catalytic core [active] 1138382006384 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1138382006385 conserved hypothetical protein; Region: TIGR03843 1138382006386 potential frameshift: common BLAST hit: gi|375142478|ref|YP_005003127.1| transposase 1138382006387 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382006388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382006389 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382006390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382006391 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138382006392 active site 1138382006393 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1138382006394 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382006395 active site 1138382006396 HIGH motif; other site 1138382006397 nucleotide binding site [chemical binding]; other site 1138382006398 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382006399 active site 1138382006400 KMSKS motif; other site 1138382006401 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1138382006402 putative tRNA binding surface [nucleotide binding]; other site 1138382006403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382006404 Walker A/P-loop; other site 1138382006405 ATP binding site [chemical binding]; other site 1138382006406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382006407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382006408 DNA binding residues [nucleotide binding] 1138382006409 dimerization interface [polypeptide binding]; other site 1138382006410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382006411 Walker A/P-loop; other site 1138382006412 ATP binding site [chemical binding]; other site 1138382006413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382006414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382006415 DNA binding residues [nucleotide binding] 1138382006416 dimerization interface [polypeptide binding]; other site 1138382006417 MbtH-like protein; Region: MbtH; pfam03621 1138382006418 Condensation domain; Region: Condensation; pfam00668 1138382006419 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382006420 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382006421 acyl-activating enzyme (AAE) consensus motif; other site 1138382006422 AMP binding site [chemical binding]; other site 1138382006423 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382006424 Condensation domain; Region: Condensation; pfam00668 1138382006425 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382006426 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382006427 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382006428 acyl-activating enzyme (AAE) consensus motif; other site 1138382006429 AMP binding site [chemical binding]; other site 1138382006430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382006431 Condensation domain; Region: Condensation; pfam00668 1138382006432 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382006433 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382006434 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382006435 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382006436 acyl-activating enzyme (AAE) consensus motif; other site 1138382006437 AMP binding site [chemical binding]; other site 1138382006438 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382006439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382006440 S-adenosylmethionine binding site [chemical binding]; other site 1138382006441 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382006442 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382006443 Condensation domain; Region: Condensation; pfam00668 1138382006444 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382006445 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382006446 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382006447 acyl-activating enzyme (AAE) consensus motif; other site 1138382006448 AMP binding site [chemical binding]; other site 1138382006449 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382006450 Condensation domain; Region: Condensation; pfam00668 1138382006451 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382006452 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382006453 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382006454 acyl-activating enzyme (AAE) consensus motif; other site 1138382006455 AMP binding site [chemical binding]; other site 1138382006456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382006457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382006458 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138382006459 putative substrate translocation pore; other site 1138382006460 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382006461 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382006462 active site 1138382006463 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1138382006464 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138382006465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382006466 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138382006467 Enoylreductase; Region: PKS_ER; smart00829 1138382006468 NAD(P) binding site [chemical binding]; other site 1138382006469 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138382006470 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382006471 putative NADP binding site [chemical binding]; other site 1138382006472 active site 1138382006473 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382006474 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382006475 Cytochrome P450; Region: p450; cl12078 1138382006476 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138382006477 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138382006478 FAD binding pocket [chemical binding]; other site 1138382006479 FAD binding motif [chemical binding]; other site 1138382006480 phosphate binding motif [ion binding]; other site 1138382006481 NAD binding pocket [chemical binding]; other site 1138382006482 acyl-CoA synthetase; Validated; Region: PRK05850 1138382006483 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138382006484 acyl-activating enzyme (AAE) consensus motif; other site 1138382006485 active site 1138382006486 short chain dehydrogenase; Provisional; Region: PRK05872 1138382006487 classical (c) SDRs; Region: SDR_c; cd05233 1138382006488 NAD(P) binding site [chemical binding]; other site 1138382006489 active site 1138382006490 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138382006491 PAC2 family; Region: PAC2; pfam09754 1138382006492 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1138382006493 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1138382006494 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1138382006495 substrate binding pocket [chemical binding]; other site 1138382006496 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1138382006497 B12 binding site [chemical binding]; other site 1138382006498 cobalt ligand [ion binding]; other site 1138382006499 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1138382006500 Mannan-binding protein; Region: MVL; pfam12151 1138382006501 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138382006502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1138382006503 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382006504 mce related protein; Region: MCE; pfam02470 1138382006505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382006506 mce related protein; Region: MCE; pfam02470 1138382006507 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382006508 mce related protein; Region: MCE; pfam02470 1138382006509 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138382006510 mce related protein; Region: MCE; pfam02470 1138382006511 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138382006512 mce related protein; Region: MCE; pfam02470 1138382006513 mce related protein; Region: MCE; pfam02470 1138382006514 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382006515 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382006516 Permease; Region: Permease; pfam02405 1138382006517 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382006518 Permease; Region: Permease; pfam02405 1138382006519 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382006520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006521 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1138382006522 homodimer interface [polypeptide binding]; other site 1138382006523 putative metal binding site [ion binding]; other site 1138382006524 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1138382006525 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1138382006526 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1138382006527 Predicted membrane protein [Function unknown]; Region: COG3918 1138382006528 mercuric reductase; Validated; Region: PRK06370 1138382006529 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382006530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382006531 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138382006532 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1138382006533 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1138382006534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382006535 S-adenosylmethionine binding site [chemical binding]; other site 1138382006536 Protein of unknown function (DUF503); Region: DUF503; cl00669 1138382006537 proteasome ATPase; Region: pup_AAA; TIGR03689 1138382006538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382006539 Walker A motif; other site 1138382006540 ATP binding site [chemical binding]; other site 1138382006541 Walker B motif; other site 1138382006542 arginine finger; other site 1138382006543 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1138382006544 Pup-like protein; Region: Pup; cl05289 1138382006545 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1138382006546 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138382006547 active site 1138382006548 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1138382006549 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138382006550 active site 1138382006551 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1138382006552 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138382006553 WYL domain; Region: WYL; pfam13280 1138382006554 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138382006555 WYL domain; Region: WYL; pfam13280 1138382006556 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1138382006557 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1138382006558 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1138382006559 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1138382006560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382006561 ATP binding site [chemical binding]; other site 1138382006562 putative Mg++ binding site [ion binding]; other site 1138382006563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382006564 nucleotide binding region [chemical binding]; other site 1138382006565 ATP-binding site [chemical binding]; other site 1138382006566 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1138382006567 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138382006568 5'-3' exonuclease; Region: 53EXOc; smart00475 1138382006569 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138382006570 active site 1138382006571 metal binding site 1 [ion binding]; metal-binding site 1138382006572 putative 5' ssDNA interaction site; other site 1138382006573 metal binding site 3; metal-binding site 1138382006574 metal binding site 2 [ion binding]; metal-binding site 1138382006575 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138382006576 putative DNA binding site [nucleotide binding]; other site 1138382006577 putative metal binding site [ion binding]; other site 1138382006578 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138382006579 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138382006580 active site 1138382006581 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382006582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382006583 short chain dehydrogenase; Provisional; Region: PRK08251 1138382006584 NAD(P) binding site [chemical binding]; other site 1138382006585 active site 1138382006586 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1138382006587 active site 1138382006588 putative homodimer interface [polypeptide binding]; other site 1138382006589 SAM binding site [chemical binding]; other site 1138382006590 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1138382006591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382006592 S-adenosylmethionine binding site [chemical binding]; other site 1138382006593 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1138382006594 active site 1138382006595 SAM binding site [chemical binding]; other site 1138382006596 homodimer interface [polypeptide binding]; other site 1138382006597 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1138382006598 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 1138382006599 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1138382006600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382006601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382006602 DNA binding residues [nucleotide binding] 1138382006603 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382006604 PPE family; Region: PPE; pfam00823 1138382006605 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1138382006606 active site 1138382006607 SAM binding site [chemical binding]; other site 1138382006608 homodimer interface [polypeptide binding]; other site 1138382006609 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1138382006610 active site 1138382006611 SAM binding site [chemical binding]; other site 1138382006612 homodimer interface [polypeptide binding]; other site 1138382006613 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1138382006614 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1138382006615 precorrin-3B synthase; Region: CobG; TIGR02435 1138382006616 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138382006617 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138382006618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382006619 dimer interface [polypeptide binding]; other site 1138382006620 conserved gate region; other site 1138382006621 putative PBP binding loops; other site 1138382006622 ABC-ATPase subunit interface; other site 1138382006623 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138382006624 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138382006625 Walker A/P-loop; other site 1138382006626 ATP binding site [chemical binding]; other site 1138382006627 Q-loop/lid; other site 1138382006628 ABC transporter signature motif; other site 1138382006629 Walker B; other site 1138382006630 D-loop; other site 1138382006631 H-loop/switch region; other site 1138382006632 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138382006633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382006634 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138382006635 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138382006636 Moco binding site; other site 1138382006637 metal coordination site [ion binding]; other site 1138382006638 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1138382006639 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138382006640 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138382006641 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138382006642 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1138382006643 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1138382006644 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1138382006645 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138382006646 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138382006647 active site 1138382006648 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1138382006649 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1138382006650 putative active site [active] 1138382006651 catalytic triad [active] 1138382006652 putative dimer interface [polypeptide binding]; other site 1138382006653 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1138382006654 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1138382006655 Ligand binding site; other site 1138382006656 Putative Catalytic site; other site 1138382006657 DXD motif; other site 1138382006658 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1138382006659 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382006660 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382006661 active site 1138382006662 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382006663 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138382006664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382006665 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138382006666 Enoylreductase; Region: PKS_ER; smart00829 1138382006667 NAD(P) binding site [chemical binding]; other site 1138382006668 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138382006669 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382006670 putative NADP binding site [chemical binding]; other site 1138382006671 active site 1138382006672 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382006673 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382006674 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382006675 active site 1138382006676 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382006677 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138382006678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382006679 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138382006680 Enoylreductase; Region: PKS_ER; smart00829 1138382006681 NAD(P) binding site [chemical binding]; other site 1138382006682 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138382006683 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382006684 putative NADP binding site [chemical binding]; other site 1138382006685 active site 1138382006686 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382006687 hypothetical protein; Provisional; Region: PRK05865 1138382006688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382006689 NAD(P) binding site [chemical binding]; other site 1138382006690 active site 1138382006691 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138382006692 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382006693 Cytochrome P450; Region: p450; cl12078 1138382006694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382006695 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1138382006696 NAD(P) binding site [chemical binding]; other site 1138382006697 active site 1138382006698 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382006699 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382006700 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138382006701 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1138382006702 Walker A motif; other site 1138382006703 ATP binding site [chemical binding]; other site 1138382006704 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138382006705 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138382006706 metal ion-dependent adhesion site (MIDAS); other site 1138382006707 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382006708 short chain dehydrogenase; Provisional; Region: PRK07814 1138382006709 classical (c) SDRs; Region: SDR_c; cd05233 1138382006710 NAD(P) binding site [chemical binding]; other site 1138382006711 active site 1138382006712 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382006713 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382006714 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382006715 classical (c) SDRs; Region: SDR_c; cd05233 1138382006716 NAD(P) binding site [chemical binding]; other site 1138382006717 active site 1138382006718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382006719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006720 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382006721 Cytochrome P450; Region: p450; cl12078 1138382006722 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138382006723 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382006724 substrate binding pocket [chemical binding]; other site 1138382006725 catalytic triad [active] 1138382006726 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382006727 Ecdysteroid kinase; Region: EcKinase; cl17738 1138382006728 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1138382006729 ATP-binding site [chemical binding]; other site 1138382006730 Gluconate-6-phosphate binding site [chemical binding]; other site 1138382006731 Shikimate kinase; Region: SKI; pfam01202 1138382006732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382006733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006734 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382006735 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382006736 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1138382006737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1138382006738 AAA domain; Region: AAA_33; pfam13671 1138382006739 Predicted membrane protein [Function unknown]; Region: COG2259 1138382006740 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1138382006741 Isochorismatase family; Region: Isochorismatase; pfam00857 1138382006742 catalytic triad [active] 1138382006743 conserved cis-peptide bond; other site 1138382006744 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138382006745 DoxX-like family; Region: DoxX_2; pfam13564 1138382006746 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138382006747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382006748 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138382006749 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138382006750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138382006751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382006752 dimer interface [polypeptide binding]; other site 1138382006753 conserved gate region; other site 1138382006754 putative PBP binding loops; other site 1138382006755 ABC-ATPase subunit interface; other site 1138382006756 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138382006757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382006758 dimer interface [polypeptide binding]; other site 1138382006759 conserved gate region; other site 1138382006760 putative PBP binding loops; other site 1138382006761 ABC-ATPase subunit interface; other site 1138382006762 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138382006763 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138382006764 Walker A/P-loop; other site 1138382006765 ATP binding site [chemical binding]; other site 1138382006766 Q-loop/lid; other site 1138382006767 ABC transporter signature motif; other site 1138382006768 Walker B; other site 1138382006769 D-loop; other site 1138382006770 H-loop/switch region; other site 1138382006771 TOBE domain; Region: TOBE_2; pfam08402 1138382006772 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138382006773 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1138382006774 nucleophile elbow; other site 1138382006775 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138382006776 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1138382006777 Iron permease FTR1 family; Region: FTR1; cl00475 1138382006778 Imelysin; Region: Peptidase_M75; pfam09375 1138382006779 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1138382006780 OsmC-like protein; Region: OsmC; pfam02566 1138382006781 cyanate hydratase; Validated; Region: PRK02866 1138382006782 Helix-turn-helix domain; Region: HTH_19; pfam12844 1138382006783 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1138382006784 oligomer interface [polypeptide binding]; other site 1138382006785 active site 1138382006786 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382006787 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382006788 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 1138382006789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1138382006790 DNA binding residues [nucleotide binding] 1138382006791 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1138382006792 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138382006793 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382006794 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382006795 active site 1138382006796 catalytic tetrad [active] 1138382006797 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138382006798 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1138382006799 putative NADP binding site [chemical binding]; other site 1138382006800 putative substrate binding site [chemical binding]; other site 1138382006801 active site 1138382006802 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138382006803 extended (e) SDRs; Region: SDR_e; cd08946 1138382006804 NAD(P) binding site [chemical binding]; other site 1138382006805 active site 1138382006806 substrate binding site [chemical binding]; other site 1138382006807 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382006808 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138382006809 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382006810 active site 2 [active] 1138382006811 active site 1 [active] 1138382006812 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1138382006813 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382006814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382006815 active site 1138382006816 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138382006817 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382006818 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1138382006819 homotetramer interface [polypeptide binding]; other site 1138382006820 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382006821 NAD binding site [chemical binding]; other site 1138382006822 homodimer interface [polypeptide binding]; other site 1138382006823 active site 1138382006824 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138382006825 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382006826 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382006827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006828 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382006829 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382006830 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382006831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382006832 substrate binding site [chemical binding]; other site 1138382006833 oxyanion hole (OAH) forming residues; other site 1138382006834 trimer interface [polypeptide binding]; other site 1138382006835 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1138382006836 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1138382006837 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1138382006838 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1138382006839 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138382006840 active site 1138382006841 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138382006842 catalytic triad [active] 1138382006843 dimer interface [polypeptide binding]; other site 1138382006844 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138382006845 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1138382006846 active site 1138382006847 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382006848 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1138382006849 active site 1138382006850 substrate binding site [chemical binding]; other site 1138382006851 ATP binding site [chemical binding]; other site 1138382006852 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1138382006853 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138382006854 potential catalytic triad [active] 1138382006855 conserved cys residue [active] 1138382006856 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382006857 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382006858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382006859 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138382006860 NAD(P) binding site [chemical binding]; other site 1138382006861 active site 1138382006862 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1138382006863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382006864 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138382006865 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1138382006866 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1138382006867 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382006868 hydrophobic ligand binding site; other site 1138382006869 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382006870 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138382006871 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138382006872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382006873 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138382006874 Cutinase; Region: Cutinase; pfam01083 1138382006875 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1138382006876 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382006877 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138382006878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382006879 active site 1138382006880 phosphorylation site [posttranslational modification] 1138382006881 intermolecular recognition site; other site 1138382006882 dimerization interface [polypeptide binding]; other site 1138382006883 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138382006884 Cutinase; Region: Cutinase; pfam01083 1138382006885 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382006886 PPE family; Region: PPE; pfam00823 1138382006887 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382006888 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138382006889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1138382006890 putative PBP binding loops; other site 1138382006891 ABC-ATPase subunit interface; other site 1138382006892 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138382006893 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138382006894 Walker A/P-loop; other site 1138382006895 ATP binding site [chemical binding]; other site 1138382006896 Q-loop/lid; other site 1138382006897 ABC transporter signature motif; other site 1138382006898 Walker B; other site 1138382006899 D-loop; other site 1138382006900 H-loop/switch region; other site 1138382006901 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1138382006902 NMT1-like family; Region: NMT1_2; pfam13379 1138382006903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138382006904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382006905 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1138382006906 putative dimerization interface [polypeptide binding]; other site 1138382006907 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382006908 PPE family; Region: PPE; pfam00823 1138382006909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1138382006910 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1138382006911 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1138382006912 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382006913 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138382006914 short chain dehydrogenase; Provisional; Region: PRK06500 1138382006915 classical (c) SDRs; Region: SDR_c; cd05233 1138382006916 NAD(P) binding site [chemical binding]; other site 1138382006917 active site 1138382006918 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138382006919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382006920 S-adenosylmethionine binding site [chemical binding]; other site 1138382006921 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1138382006922 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1138382006923 putative oligomer interface [polypeptide binding]; other site 1138382006924 putative active site [active] 1138382006925 metal binding site [ion binding]; metal-binding site 1138382006926 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138382006927 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382006928 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382006929 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1138382006930 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138382006931 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138382006932 hypothetical protein; Provisional; Region: PRK06834 1138382006933 hypothetical protein; Provisional; Region: PRK07236 1138382006934 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382006935 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1138382006936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382006937 ATP binding site [chemical binding]; other site 1138382006938 putative Mg++ binding site [ion binding]; other site 1138382006939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382006940 nucleotide binding region [chemical binding]; other site 1138382006941 ATP-binding site [chemical binding]; other site 1138382006942 Helicase associated domain (HA2); Region: HA2; pfam04408 1138382006943 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1138382006944 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1138382006945 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1138382006946 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382006947 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382006948 substrate binding site [chemical binding]; other site 1138382006949 oxyanion hole (OAH) forming residues; other site 1138382006950 trimer interface [polypeptide binding]; other site 1138382006951 Cutinase; Region: Cutinase; pfam01083 1138382006952 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1138382006953 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382006954 catalytic Zn binding site [ion binding]; other site 1138382006955 NAD(P) binding site [chemical binding]; other site 1138382006956 structural Zn binding site [ion binding]; other site 1138382006957 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382006958 hydrophobic ligand binding site; other site 1138382006959 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1138382006960 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382006961 NAD binding site [chemical binding]; other site 1138382006962 catalytic Zn binding site [ion binding]; other site 1138382006963 structural Zn binding site [ion binding]; other site 1138382006964 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1138382006965 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1138382006966 MOSC domain; Region: MOSC; pfam03473 1138382006967 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382006968 PPE family; Region: PPE; pfam00823 1138382006969 Short C-terminal domain; Region: SHOCT; pfam09851 1138382006970 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138382006971 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138382006972 active site 1138382006973 TDP-binding site; other site 1138382006974 acceptor substrate-binding pocket; other site 1138382006975 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382006976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382006977 S-adenosylmethionine binding site [chemical binding]; other site 1138382006978 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138382006979 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1138382006980 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382006981 iron-sulfur cluster [ion binding]; other site 1138382006982 [2Fe-2S] cluster binding site [ion binding]; other site 1138382006983 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1138382006984 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138382006985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138382006986 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138382006987 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138382006988 metal binding site 2 [ion binding]; metal-binding site 1138382006989 putative DNA binding helix; other site 1138382006990 metal binding site 1 [ion binding]; metal-binding site 1138382006991 dimer interface [polypeptide binding]; other site 1138382006992 structural Zn2+ binding site [ion binding]; other site 1138382006993 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1138382006994 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1138382006995 dimer interface [polypeptide binding]; other site 1138382006996 active site 1138382006997 heme binding site [chemical binding]; other site 1138382006998 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1138382006999 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1138382007000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382007001 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382007002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382007003 S-adenosylmethionine binding site [chemical binding]; other site 1138382007004 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1138382007005 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1138382007006 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138382007007 Cutinase; Region: Cutinase; pfam01083 1138382007008 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382007009 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382007010 PE family; Region: PE; pfam00934 1138382007011 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1138382007012 active site 1138382007013 catalytic residues [active] 1138382007014 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382007015 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138382007016 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382007017 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382007018 NAD(P) binding site [chemical binding]; other site 1138382007019 catalytic residues [active] 1138382007020 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1138382007021 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382007022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382007023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138382007024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382007025 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382007026 extended (e) SDRs; Region: SDR_e; cd08946 1138382007027 NAD(P) binding site [chemical binding]; other site 1138382007028 active site 1138382007029 substrate binding site [chemical binding]; other site 1138382007030 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382007031 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382007032 active site 1138382007033 YacP-like NYN domain; Region: NYN_YacP; cl01491 1138382007034 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1138382007035 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382007036 FMN binding site [chemical binding]; other site 1138382007037 substrate binding site [chemical binding]; other site 1138382007038 putative catalytic residue [active] 1138382007039 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1138382007040 dimer interface [polypeptide binding]; other site 1138382007041 catalytic triad [active] 1138382007042 peroxidatic and resolving cysteines [active] 1138382007043 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138382007044 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138382007045 conserved cys residue [active] 1138382007046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382007047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382007048 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138382007049 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138382007050 conserved cys residue [active] 1138382007051 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138382007052 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138382007053 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1138382007054 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382007055 short chain dehydrogenase; Provisional; Region: PRK05867 1138382007056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382007057 NAD(P) binding site [chemical binding]; other site 1138382007058 active site 1138382007059 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382007060 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382007061 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1138382007062 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138382007063 acyl-activating enzyme (AAE) consensus motif; other site 1138382007064 active site 1138382007065 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138382007066 putative hydrophobic ligand binding site [chemical binding]; other site 1138382007067 protein interface [polypeptide binding]; other site 1138382007068 gate; other site 1138382007069 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138382007070 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382007071 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138382007072 tetramer interface [polypeptide binding]; other site 1138382007073 active site 1138382007074 Mg2+/Mn2+ binding site [ion binding]; other site 1138382007075 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1138382007076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382007077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382007078 dimerization interface [polypeptide binding]; other site 1138382007079 putative DNA binding site [nucleotide binding]; other site 1138382007080 putative Zn2+ binding site [ion binding]; other site 1138382007081 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1138382007082 putative hydrophobic ligand binding site [chemical binding]; other site 1138382007083 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138382007084 putative hydrophobic ligand binding site [chemical binding]; other site 1138382007085 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138382007086 substrate binding site [chemical binding]; other site 1138382007087 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138382007088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382007089 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382007090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007091 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1138382007092 Nitronate monooxygenase; Region: NMO; pfam03060 1138382007093 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382007094 FMN binding site [chemical binding]; other site 1138382007095 substrate binding site [chemical binding]; other site 1138382007096 putative catalytic residue [active] 1138382007097 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138382007098 FMN binding site [chemical binding]; other site 1138382007099 dimer interface [polypeptide binding]; other site 1138382007100 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382007101 hydrophobic ligand binding site; other site 1138382007102 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138382007103 Predicted membrane protein [Function unknown]; Region: COG1950 1138382007104 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382007105 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382007106 active site 1138382007107 Integrase core domain; Region: rve; pfam00665 1138382007108 Integrase core domain; Region: rve_3; pfam13683 1138382007109 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382007110 putative sialic acid transporter; Region: 2A0112; TIGR00891 1138382007111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382007112 putative substrate translocation pore; other site 1138382007113 competence damage-inducible protein A; Provisional; Region: PRK00549 1138382007114 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1138382007115 putative MPT binding site; other site 1138382007116 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1138382007117 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1138382007118 putative ADP-ribose binding site [chemical binding]; other site 1138382007119 Domain of unknown function DUF77; Region: DUF77; pfam01910 1138382007120 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1138382007121 putative active site [active] 1138382007122 dimerization interface [polypeptide binding]; other site 1138382007123 putative tRNAtyr binding site [nucleotide binding]; other site 1138382007124 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382007125 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382007126 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138382007127 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382007128 NAD(P) binding site [chemical binding]; other site 1138382007129 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382007130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382007131 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382007132 Nitronate monooxygenase; Region: NMO; pfam03060 1138382007133 FMN binding site [chemical binding]; other site 1138382007134 substrate binding site [chemical binding]; other site 1138382007135 putative catalytic residue [active] 1138382007136 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382007137 Cytochrome P450; Region: p450; cl12078 1138382007138 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1138382007139 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1138382007140 putative NAD(P) binding site [chemical binding]; other site 1138382007141 putative substrate binding site [chemical binding]; other site 1138382007142 catalytic Zn binding site [ion binding]; other site 1138382007143 structural Zn binding site [ion binding]; other site 1138382007144 YceI-like domain; Region: YceI; smart00867 1138382007145 Putative esterase; Region: Esterase; pfam00756 1138382007146 chorismate mutase; Provisional; Region: PRK09269 1138382007147 Chorismate mutase type II; Region: CM_2; cl00693 1138382007148 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138382007149 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382007150 hydrophobic ligand binding site; other site 1138382007151 short chain dehydrogenase; Provisional; Region: PRK08267 1138382007152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382007153 NAD(P) binding site [chemical binding]; other site 1138382007154 active site 1138382007155 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138382007156 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382007157 Cytochrome P450; Region: p450; cl12078 1138382007158 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382007159 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382007160 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138382007161 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138382007162 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1138382007163 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382007164 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382007165 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382007166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382007167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138382007168 putative substrate translocation pore; other site 1138382007169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382007170 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1138382007171 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1138382007172 heme binding site [chemical binding]; other site 1138382007173 ferroxidase pore; other site 1138382007174 ferroxidase diiron center [ion binding]; other site 1138382007175 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1138382007176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382007177 substrate binding site [chemical binding]; other site 1138382007178 oxyanion hole (OAH) forming residues; other site 1138382007179 trimer interface [polypeptide binding]; other site 1138382007180 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382007181 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1138382007182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382007183 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1138382007184 dimerization interface [polypeptide binding]; other site 1138382007185 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138382007186 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1138382007187 dimer interface [polypeptide binding]; other site 1138382007188 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1138382007189 catalytic triad [active] 1138382007190 peroxidatic and resolving cysteines [active] 1138382007191 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1138382007192 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382007193 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1138382007194 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138382007195 active site 1138382007196 catalytic site [active] 1138382007197 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1138382007198 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1138382007199 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1138382007200 active site 1138382007201 substrate binding site [chemical binding]; other site 1138382007202 FMN binding site [chemical binding]; other site 1138382007203 putative catalytic residues [active] 1138382007204 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1138382007205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382007206 Walker A motif; other site 1138382007207 ATP binding site [chemical binding]; other site 1138382007208 Walker B motif; other site 1138382007209 arginine finger; other site 1138382007210 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1138382007211 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382007212 TfoX N-terminal domain; Region: TfoX_N; cl17592 1138382007213 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138382007214 minor groove reading motif; other site 1138382007215 helix-hairpin-helix signature motif; other site 1138382007216 Protein of unknown function DUF72; Region: DUF72; pfam01904 1138382007217 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138382007218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382007219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382007220 hypothetical protein; Provisional; Region: PRK12320 1138382007221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382007222 NAD(P) binding site [chemical binding]; other site 1138382007223 active site 1138382007224 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138382007225 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382007226 active site 1138382007227 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382007228 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382007229 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382007230 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382007231 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1138382007232 short chain dehydrogenase; Provisional; Region: PRK07825 1138382007233 classical (c) SDRs; Region: SDR_c; cd05233 1138382007234 NAD(P) binding site [chemical binding]; other site 1138382007235 active site 1138382007236 putative phosphoketolase; Provisional; Region: PRK05261 1138382007237 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1138382007238 TPP-binding site; other site 1138382007239 XFP C-terminal domain; Region: XFP_C; pfam09363 1138382007240 CAAX protease self-immunity; Region: Abi; pfam02517 1138382007241 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138382007242 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1138382007243 NAD(P) binding site [chemical binding]; other site 1138382007244 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1138382007245 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1138382007246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382007247 Walker A/P-loop; other site 1138382007248 ATP binding site [chemical binding]; other site 1138382007249 Q-loop/lid; other site 1138382007250 ABC transporter signature motif; other site 1138382007251 Walker B; other site 1138382007252 D-loop; other site 1138382007253 H-loop/switch region; other site 1138382007254 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138382007255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382007256 putative PBP binding loops; other site 1138382007257 ABC-ATPase subunit interface; other site 1138382007258 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1138382007259 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1138382007260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138382007261 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138382007262 classical (c) SDRs; Region: SDR_c; cd05233 1138382007263 NAD(P) binding site [chemical binding]; other site 1138382007264 active site 1138382007265 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138382007266 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382007267 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382007268 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1138382007269 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138382007270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382007271 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382007272 CoenzymeA binding site [chemical binding]; other site 1138382007273 subunit interaction site [polypeptide binding]; other site 1138382007274 PHB binding site; other site 1138382007275 Predicted transcriptional regulator [Transcription]; Region: COG3682 1138382007276 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138382007277 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1138382007278 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1138382007279 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1138382007280 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138382007281 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138382007282 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138382007283 active site 1138382007284 acyl carrier protein; Validated; Region: PRK05883 1138382007285 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1138382007286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382007287 acyl-activating enzyme (AAE) consensus motif; other site 1138382007288 AMP binding site [chemical binding]; other site 1138382007289 active site 1138382007290 CoA binding site [chemical binding]; other site 1138382007291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382007292 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382007293 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382007294 active site 1138382007295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138382007296 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138382007297 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138382007298 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138382007299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138382007300 Transporter associated domain; Region: CorC_HlyC; smart01091 1138382007301 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138382007302 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138382007303 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138382007304 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1138382007305 active site 1138382007306 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1138382007307 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138382007308 metal ion-dependent adhesion site (MIDAS); other site 1138382007309 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138382007310 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138382007311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382007312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007313 glycine dehydrogenase; Provisional; Region: PRK05367 1138382007314 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138382007315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382007316 tetramer interface [polypeptide binding]; other site 1138382007317 catalytic residue [active] 1138382007318 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138382007319 tetramer interface [polypeptide binding]; other site 1138382007320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382007321 catalytic residue [active] 1138382007322 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1138382007323 DNA binding residues [nucleotide binding] 1138382007324 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138382007325 putative dimer interface [polypeptide binding]; other site 1138382007326 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1138382007327 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1138382007328 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138382007329 DNA binding residues [nucleotide binding] 1138382007330 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382007331 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382007332 phosphopeptide binding site; other site 1138382007333 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1138382007334 lipoyl attachment site [posttranslational modification]; other site 1138382007335 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138382007336 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1138382007337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138382007338 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138382007339 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138382007340 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1138382007341 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1138382007342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1138382007343 nucleotide binding region [chemical binding]; other site 1138382007344 ATP-binding site [chemical binding]; other site 1138382007345 hypothetical protein; Provisional; Region: PRK05858 1138382007346 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138382007347 PYR/PP interface [polypeptide binding]; other site 1138382007348 dimer interface [polypeptide binding]; other site 1138382007349 TPP binding site [chemical binding]; other site 1138382007350 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382007351 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138382007352 TPP-binding site; other site 1138382007353 dimer interface [polypeptide binding]; other site 1138382007354 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1138382007355 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1138382007356 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1138382007357 hypothetical protein; Validated; Region: PRK07121 1138382007358 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138382007359 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138382007360 active site 1138382007361 metal binding site [ion binding]; metal-binding site 1138382007362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382007363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007364 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1138382007365 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1138382007366 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1138382007367 MgtC family; Region: MgtC; pfam02308 1138382007368 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382007369 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007370 PPE family; Region: PPE; pfam00823 1138382007371 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382007372 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007373 PPE family; Region: PPE; pfam00823 1138382007374 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382007375 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382007376 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382007377 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007378 PPE family; Region: PPE; pfam00823 1138382007379 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382007380 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007381 PPE family; Region: PPE; pfam00823 1138382007382 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382007383 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007384 PPE family; Region: PPE; pfam00823 1138382007385 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138382007386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382007387 Walker A motif; other site 1138382007388 ATP binding site [chemical binding]; other site 1138382007389 Walker B motif; other site 1138382007390 arginine finger; other site 1138382007391 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138382007392 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138382007393 catalytic residues [active] 1138382007394 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138382007395 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1138382007396 active site 1138382007397 catalytic residues [active] 1138382007398 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138382007399 EspG family; Region: ESX-1_EspG; pfam14011 1138382007400 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138382007401 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138382007402 PE family; Region: PE; pfam00934 1138382007403 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007404 PPE family; Region: PPE; pfam00823 1138382007405 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007406 PPE family; Region: PPE; pfam00823 1138382007407 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007408 PPE family; Region: PPE; pfam00823 1138382007409 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382007410 PPE family; Region: PPE; pfam00823 1138382007411 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382007412 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138382007413 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382007414 Cytochrome P450; Region: p450; cl12078 1138382007415 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138382007416 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382007417 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138382007418 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382007419 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138382007420 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1138382007421 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1138382007422 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382007423 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382007424 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382007425 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1138382007426 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1138382007427 Moco binding site; other site 1138382007428 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138382007429 metal coordination site [ion binding]; other site 1138382007430 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138382007431 hydrophobic ligand binding site; other site 1138382007432 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1138382007433 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382007434 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382007435 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138382007436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382007437 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382007438 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382007439 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382007440 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382007441 classical (c) SDRs; Region: SDR_c; cd05233 1138382007442 NAD(P) binding site [chemical binding]; other site 1138382007443 active site 1138382007444 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1138382007445 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138382007446 tetramer interface [polypeptide binding]; other site 1138382007447 TPP-binding site [chemical binding]; other site 1138382007448 heterodimer interface [polypeptide binding]; other site 1138382007449 phosphorylation loop region [posttranslational modification] 1138382007450 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1138382007451 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1138382007452 alpha subunit interface [polypeptide binding]; other site 1138382007453 TPP binding site [chemical binding]; other site 1138382007454 heterodimer interface [polypeptide binding]; other site 1138382007455 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138382007456 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138382007457 E3 interaction surface; other site 1138382007458 lipoyl attachment site [posttranslational modification]; other site 1138382007459 enoyl-CoA hydratase; Provisional; Region: PRK06144 1138382007460 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382007461 substrate binding site [chemical binding]; other site 1138382007462 oxyanion hole (OAH) forming residues; other site 1138382007463 trimer interface [polypeptide binding]; other site 1138382007464 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138382007465 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382007466 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382007467 acyl-activating enzyme (AAE) consensus motif; other site 1138382007468 acyl-activating enzyme (AAE) consensus motif; other site 1138382007469 putative AMP binding site [chemical binding]; other site 1138382007470 putative active site [active] 1138382007471 putative CoA binding site [chemical binding]; other site 1138382007472 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382007473 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382007474 [2Fe-2S] cluster binding site [ion binding]; other site 1138382007475 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382007476 hydrophobic ligand binding site; other site 1138382007477 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1138382007478 enoyl-CoA hydratase; Provisional; Region: PRK06190 1138382007479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382007480 substrate binding site [chemical binding]; other site 1138382007481 oxyanion hole (OAH) forming residues; other site 1138382007482 trimer interface [polypeptide binding]; other site 1138382007483 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1138382007484 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1138382007485 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 1138382007486 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1138382007487 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138382007488 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1138382007489 ATP binding site [chemical binding]; other site 1138382007490 Mg++ binding site [ion binding]; other site 1138382007491 motif III; other site 1138382007492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382007493 nucleotide binding region [chemical binding]; other site 1138382007494 ATP-binding site [chemical binding]; other site 1138382007495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382007496 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382007497 S-adenosylmethionine binding site [chemical binding]; other site 1138382007498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382007499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007500 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138382007501 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382007502 active site 1138382007503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382007504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382007505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007506 classical (c) SDRs; Region: SDR_c; cd05233 1138382007507 NAD(P) binding site [chemical binding]; other site 1138382007508 active site 1138382007509 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1138382007510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382007511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138382007512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382007513 DNA binding residues [nucleotide binding] 1138382007514 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138382007515 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1138382007516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007517 Cytochrome P450; Region: p450; cl12078 1138382007518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382007519 short chain dehydrogenase; Provisional; Region: PRK05854 1138382007520 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138382007521 putative NAD(P) binding site [chemical binding]; other site 1138382007522 active site 1138382007523 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382007524 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138382007525 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138382007526 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138382007527 active site 1138382007528 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138382007529 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138382007530 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138382007531 active site 1138382007532 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382007533 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382007534 active site 1138382007535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382007536 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138382007537 NAD(P) binding site [chemical binding]; other site 1138382007538 active site 1138382007539 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382007540 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382007541 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382007542 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382007543 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382007544 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138382007545 substrate binding site [chemical binding]; other site 1138382007546 oxyanion hole (OAH) forming residues; other site 1138382007547 trimer interface [polypeptide binding]; other site 1138382007548 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382007549 classical (c) SDRs; Region: SDR_c; cd05233 1138382007550 NAD(P) binding site [chemical binding]; other site 1138382007551 active site 1138382007552 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382007553 Cytochrome P450; Region: p450; cl12078 1138382007554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382007555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007556 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1138382007557 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1138382007558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138382007559 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1138382007560 hypothetical protein; Provisional; Region: PRK06185 1138382007561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382007562 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382007563 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138382007564 Sulfatase; Region: Sulfatase; pfam00884 1138382007565 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382007566 FMN binding site [chemical binding]; other site 1138382007567 substrate binding site [chemical binding]; other site 1138382007568 putative catalytic residue [active] 1138382007569 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382007570 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138382007571 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382007572 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1138382007573 intersubunit interface [polypeptide binding]; other site 1138382007574 active site 1138382007575 Zn2+ binding site [ion binding]; other site 1138382007576 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382007577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382007578 acyl-activating enzyme (AAE) consensus motif; other site 1138382007579 AMP binding site [chemical binding]; other site 1138382007580 active site 1138382007581 CoA binding site [chemical binding]; other site 1138382007582 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138382007583 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1138382007584 Moco binding site; other site 1138382007585 metal coordination site [ion binding]; other site 1138382007586 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138382007587 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1138382007588 putative di-iron ligands [ion binding]; other site 1138382007589 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138382007590 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138382007591 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138382007592 FAD binding pocket [chemical binding]; other site 1138382007593 FAD binding motif [chemical binding]; other site 1138382007594 phosphate binding motif [ion binding]; other site 1138382007595 beta-alpha-beta structure motif; other site 1138382007596 NAD binding pocket [chemical binding]; other site 1138382007597 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382007598 catalytic loop [active] 1138382007599 iron binding site [ion binding]; other site 1138382007600 acyl-CoA synthetase; Provisional; Region: PRK13388 1138382007601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382007602 acyl-activating enzyme (AAE) consensus motif; other site 1138382007603 AMP binding site [chemical binding]; other site 1138382007604 active site 1138382007605 CoA binding site [chemical binding]; other site 1138382007606 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382007607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382007608 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382007609 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382007610 thiolase; Provisional; Region: PRK06158 1138382007611 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382007612 active site 1138382007613 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138382007614 putative active site [active] 1138382007615 putative catalytic site [active] 1138382007616 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138382007617 active site 1138382007618 catalytic site [active] 1138382007619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382007620 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382007621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382007622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382007623 active site 1138382007624 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382007625 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382007626 phosphopeptide binding site; other site 1138382007627 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382007628 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382007629 phosphopeptide binding site; other site 1138382007630 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138382007631 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138382007632 Walker A/P-loop; other site 1138382007633 ATP binding site [chemical binding]; other site 1138382007634 Q-loop/lid; other site 1138382007635 ABC transporter signature motif; other site 1138382007636 Walker B; other site 1138382007637 D-loop; other site 1138382007638 H-loop/switch region; other site 1138382007639 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138382007640 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138382007641 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382007642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382007643 short chain dehydrogenase; Provisional; Region: PRK06057 1138382007644 classical (c) SDRs; Region: SDR_c; cd05233 1138382007645 NAD(P) binding site [chemical binding]; other site 1138382007646 active site 1138382007647 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382007648 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138382007649 molybdopterin cofactor binding site; other site 1138382007650 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138382007651 putative molybdopterin cofactor binding site; other site 1138382007652 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382007653 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382007654 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382007655 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382007656 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138382007657 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382007658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382007659 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138382007660 NAD(P) binding site [chemical binding]; other site 1138382007661 active site 1138382007662 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382007663 classical (c) SDRs; Region: SDR_c; cd05233 1138382007664 NAD(P) binding site [chemical binding]; other site 1138382007665 active site 1138382007666 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382007667 classical (c) SDRs; Region: SDR_c; cd05233 1138382007668 NAD(P) binding site [chemical binding]; other site 1138382007669 active site 1138382007670 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382007671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382007672 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382007673 catalytic loop [active] 1138382007674 iron binding site [ion binding]; other site 1138382007675 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382007676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382007677 active site 1138382007678 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138382007679 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1138382007680 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1138382007681 active site 1138382007682 Fe binding site [ion binding]; other site 1138382007683 hypothetical protein; Validated; Region: PRK07121 1138382007684 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138382007685 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382007686 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138382007687 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138382007688 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382007689 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382007690 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138382007691 active site 1138382007692 FMN binding site [chemical binding]; other site 1138382007693 substrate binding site [chemical binding]; other site 1138382007694 putative catalytic residue [active] 1138382007695 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1138382007696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382007697 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138382007698 NAD(P) binding site [chemical binding]; other site 1138382007699 active site 1138382007700 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382007701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382007702 acyl-CoA synthetase; Validated; Region: PRK08316 1138382007703 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382007704 acyl-activating enzyme (AAE) consensus motif; other site 1138382007705 putative AMP binding site [chemical binding]; other site 1138382007706 putative active site [active] 1138382007707 putative CoA binding site [chemical binding]; other site 1138382007708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382007709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382007710 active site 1138382007711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382007712 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382007713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382007714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382007715 SnoaL-like domain; Region: SnoaL_4; cl17707 1138382007716 hypothetical protein; Provisional; Region: PRK06194 1138382007717 classical (c) SDRs; Region: SDR_c; cd05233 1138382007718 NAD(P) binding site [chemical binding]; other site 1138382007719 active site 1138382007720 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382007721 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382007722 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382007723 classical (c) SDRs; Region: SDR_c; cd05233 1138382007724 NAD(P) binding site [chemical binding]; other site 1138382007725 active site 1138382007726 short chain dehydrogenase; Provisional; Region: PRK08303 1138382007727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382007728 NAD(P) binding site [chemical binding]; other site 1138382007729 active site 1138382007730 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382007731 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1138382007732 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1138382007733 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138382007734 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382007735 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382007736 active site 1138382007737 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138382007738 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138382007739 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382007740 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382007741 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138382007742 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138382007743 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1138382007744 hypothetical protein; Provisional; Region: PRK14059 1138382007745 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1138382007746 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382007747 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382007748 active site 1138382007749 ATP binding site [chemical binding]; other site 1138382007750 substrate binding site [chemical binding]; other site 1138382007751 activation loop (A-loop); other site 1138382007752 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1138382007753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382007754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382007755 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1138382007756 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138382007757 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382007758 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382007759 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1138382007760 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1138382007761 dimer interface [polypeptide binding]; other site 1138382007762 active site 1138382007763 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1138382007764 Ligand Binding Site [chemical binding]; other site 1138382007765 Molecular Tunnel; other site 1138382007766 Condensation domain; Region: Condensation; pfam00668 1138382007767 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007768 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382007769 acyl-activating enzyme (AAE) consensus motif; other site 1138382007770 AMP binding site [chemical binding]; other site 1138382007771 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007772 Condensation domain; Region: Condensation; pfam00668 1138382007773 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382007774 Condensation domain; Region: Condensation; pfam00668 1138382007775 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382007776 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007777 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382007778 acyl-activating enzyme (AAE) consensus motif; other site 1138382007779 AMP binding site [chemical binding]; other site 1138382007780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382007781 S-adenosylmethionine binding site [chemical binding]; other site 1138382007782 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382007783 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007784 Condensation domain; Region: Condensation; pfam00668 1138382007785 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382007786 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382007787 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007788 acyl-activating enzyme (AAE) consensus motif; other site 1138382007789 AMP binding site [chemical binding]; other site 1138382007790 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007791 Condensation domain; Region: Condensation; pfam00668 1138382007792 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382007793 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382007794 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007795 acyl-activating enzyme (AAE) consensus motif; other site 1138382007796 AMP binding site [chemical binding]; other site 1138382007797 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007798 peptide synthase; Provisional; Region: PRK12316 1138382007799 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382007800 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007801 acyl-activating enzyme (AAE) consensus motif; other site 1138382007802 AMP binding site [chemical binding]; other site 1138382007803 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007804 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382007805 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382007806 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007807 acyl-activating enzyme (AAE) consensus motif; other site 1138382007808 AMP binding site [chemical binding]; other site 1138382007809 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007810 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382007811 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007812 acyl-activating enzyme (AAE) consensus motif; other site 1138382007813 AMP binding site [chemical binding]; other site 1138382007814 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007815 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382007816 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382007817 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382007818 acyl-activating enzyme (AAE) consensus motif; other site 1138382007819 AMP binding site [chemical binding]; other site 1138382007820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382007821 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1138382007822 MbtH-like protein; Region: MbtH; pfam03621 1138382007823 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138382007824 PAS fold; Region: PAS_4; pfam08448 1138382007825 ANTAR domain; Region: ANTAR; pfam03861 1138382007826 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138382007827 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138382007828 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138382007829 DNA-binding site [nucleotide binding]; DNA binding site 1138382007830 RNA-binding motif; other site 1138382007831 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138382007832 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138382007833 putative di-iron ligands [ion binding]; other site 1138382007834 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1138382007835 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1138382007836 NAD(P) binding site [chemical binding]; other site 1138382007837 catalytic residues [active] 1138382007838 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1138382007839 GTP-binding protein Der; Reviewed; Region: PRK03003 1138382007840 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1138382007841 GTP/Mg2+ binding site [chemical binding]; other site 1138382007842 Switch I region; other site 1138382007843 G2 box; other site 1138382007844 Switch II region; other site 1138382007845 G3 box; other site 1138382007846 G4 box; other site 1138382007847 G5 box; other site 1138382007848 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1138382007849 G1 box; other site 1138382007850 GTP/Mg2+ binding site [chemical binding]; other site 1138382007851 Switch I region; other site 1138382007852 G2 box; other site 1138382007853 G3 box; other site 1138382007854 Switch II region; other site 1138382007855 G4 box; other site 1138382007856 G5 box; other site 1138382007857 cytidylate kinase; Provisional; Region: cmk; PRK00023 1138382007858 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1138382007859 CMP-binding site; other site 1138382007860 The sites determining sugar specificity; other site 1138382007861 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1138382007862 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138382007863 RNA binding surface [nucleotide binding]; other site 1138382007864 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1138382007865 active site 1138382007866 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1138382007867 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1138382007868 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138382007869 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138382007870 P loop; other site 1138382007871 Nucleotide binding site [chemical binding]; other site 1138382007872 DTAP/Switch II; other site 1138382007873 Switch I; other site 1138382007874 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138382007875 Magnesium ion binding site [ion binding]; other site 1138382007876 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138382007877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382007878 S-adenosylmethionine binding site [chemical binding]; other site 1138382007879 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1138382007880 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138382007881 active site 1138382007882 DNA binding site [nucleotide binding] 1138382007883 Int/Topo IB signature motif; other site 1138382007884 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1138382007885 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1138382007886 dimer interface [polypeptide binding]; other site 1138382007887 active site 1138382007888 ADP-ribose binding site [chemical binding]; other site 1138382007889 nudix motif; other site 1138382007890 metal binding site [ion binding]; metal-binding site 1138382007891 CTP synthetase; Validated; Region: pyrG; PRK05380 1138382007892 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1138382007893 Catalytic site [active] 1138382007894 active site 1138382007895 UTP binding site [chemical binding]; other site 1138382007896 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1138382007897 active site 1138382007898 putative oxyanion hole; other site 1138382007899 catalytic triad [active] 1138382007900 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1138382007901 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1138382007902 Thiamine pyrophosphokinase; Region: TPK; cl08415 1138382007903 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1138382007904 DNA repair protein RecN; Region: recN; TIGR00634 1138382007905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382007906 Walker A/P-loop; other site 1138382007907 ATP binding site [chemical binding]; other site 1138382007908 Q-loop/lid; other site 1138382007909 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1138382007910 ABC transporter signature motif; other site 1138382007911 Walker B; other site 1138382007912 D-loop; other site 1138382007913 H-loop/switch region; other site 1138382007914 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1138382007915 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1138382007916 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1138382007917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138382007918 RNA binding surface [nucleotide binding]; other site 1138382007919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382007920 S-adenosylmethionine binding site [chemical binding]; other site 1138382007921 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1138382007922 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1138382007923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382007924 active site 1138382007925 motif I; other site 1138382007926 motif II; other site 1138382007927 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1138382007928 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1138382007929 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382007930 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1138382007931 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1138382007932 active site 1138382007933 HIGH motif; other site 1138382007934 dimer interface [polypeptide binding]; other site 1138382007935 KMSKS motif; other site 1138382007936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138382007937 RNA binding surface [nucleotide binding]; other site 1138382007938 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382007939 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382007940 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1138382007941 active site 1138382007942 DNA binding site [nucleotide binding] 1138382007943 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1138382007944 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138382007945 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138382007946 Walker A/P-loop; other site 1138382007947 ATP binding site [chemical binding]; other site 1138382007948 Q-loop/lid; other site 1138382007949 ABC transporter signature motif; other site 1138382007950 Walker B; other site 1138382007951 D-loop; other site 1138382007952 H-loop/switch region; other site 1138382007953 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382007954 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138382007955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382007956 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1138382007957 acyl-CoA synthetase; Validated; Region: PRK07868 1138382007958 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1138382007959 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382007960 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382007961 active site 1138382007962 CoA binding site [chemical binding]; other site 1138382007963 AMP binding site [chemical binding]; other site 1138382007964 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1138382007965 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138382007966 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138382007967 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138382007968 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1138382007969 short chain dehydrogenase; Provisional; Region: PRK07109 1138382007970 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1138382007971 putative NAD(P) binding site [chemical binding]; other site 1138382007972 active site 1138382007973 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 1138382007974 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138382007975 putative active site pocket [active] 1138382007976 putative metal binding site [ion binding]; other site 1138382007977 PAS fold; Region: PAS_3; pfam08447 1138382007978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138382007979 putative active site [active] 1138382007980 heme pocket [chemical binding]; other site 1138382007981 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382007982 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138382007983 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138382007984 ABC transporter; Region: ABC_tran_2; pfam12848 1138382007985 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138382007986 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382007987 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382007988 active site 1138382007989 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138382007990 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138382007991 malonyl-CoA binding site [chemical binding]; other site 1138382007992 dimer interface [polypeptide binding]; other site 1138382007993 active site 1138382007994 product binding site; other site 1138382007995 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382007996 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382007997 active site 1138382007998 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382007999 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382008000 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382008001 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382008002 active site 1138382008003 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382008004 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138382008005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382008006 Enoylreductase; Region: PKS_ER; smart00829 1138382008007 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138382008008 NAD(P) binding site [chemical binding]; other site 1138382008009 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138382008010 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382008011 putative NADP binding site [chemical binding]; other site 1138382008012 active site 1138382008013 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382008014 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138382008015 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138382008016 active site 1138382008017 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138382008018 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138382008019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382008020 Enoylreductase; Region: PKS_ER; smart00829 1138382008021 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138382008022 NAD(P) binding site [chemical binding]; other site 1138382008023 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138382008024 putative NADP binding site [chemical binding]; other site 1138382008025 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382008026 active site 1138382008027 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138382008028 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138382008029 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138382008030 malonyl-CoA binding site [chemical binding]; other site 1138382008031 dimer interface [polypeptide binding]; other site 1138382008032 active site 1138382008033 product binding site; other site 1138382008034 argininosuccinate lyase; Provisional; Region: PRK00855 1138382008035 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1138382008036 active sites [active] 1138382008037 tetramer interface [polypeptide binding]; other site 1138382008038 argininosuccinate synthase; Provisional; Region: PRK13820 1138382008039 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1138382008040 ANP binding site [chemical binding]; other site 1138382008041 Substrate Binding Site II [chemical binding]; other site 1138382008042 Substrate Binding Site I [chemical binding]; other site 1138382008043 arginine repressor; Provisional; Region: PRK03341 1138382008044 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1138382008045 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1138382008046 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1138382008047 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138382008048 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138382008049 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1138382008050 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138382008051 inhibitor-cofactor binding pocket; inhibition site 1138382008052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382008053 catalytic residue [active] 1138382008054 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1138382008055 feedback inhibition sensing region; other site 1138382008056 homohexameric interface [polypeptide binding]; other site 1138382008057 nucleotide binding site [chemical binding]; other site 1138382008058 N-acetyl-L-glutamate binding site [chemical binding]; other site 1138382008059 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1138382008060 heterotetramer interface [polypeptide binding]; other site 1138382008061 active site pocket [active] 1138382008062 cleavage site 1138382008063 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1138382008064 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138382008065 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1138382008066 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1138382008067 putative tRNA-binding site [nucleotide binding]; other site 1138382008068 B3/4 domain; Region: B3_4; pfam03483 1138382008069 tRNA synthetase B5 domain; Region: B5; smart00874 1138382008070 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1138382008071 dimer interface [polypeptide binding]; other site 1138382008072 motif 1; other site 1138382008073 motif 3; other site 1138382008074 motif 2; other site 1138382008075 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1138382008076 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1138382008077 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1138382008078 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1138382008079 dimer interface [polypeptide binding]; other site 1138382008080 motif 1; other site 1138382008081 active site 1138382008082 motif 2; other site 1138382008083 motif 3; other site 1138382008084 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382008085 cyclase homology domain; Region: CHD; cd07302 1138382008086 nucleotidyl binding site; other site 1138382008087 metal binding site [ion binding]; metal-binding site 1138382008088 dimer interface [polypeptide binding]; other site 1138382008089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138382008090 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138382008091 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1138382008092 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138382008093 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1138382008094 23S rRNA binding site [nucleotide binding]; other site 1138382008095 L21 binding site [polypeptide binding]; other site 1138382008096 L13 binding site [polypeptide binding]; other site 1138382008097 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1138382008098 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1138382008099 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1138382008100 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1138382008101 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1138382008102 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138382008103 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138382008104 dimer interface [polypeptide binding]; other site 1138382008105 putative anticodon binding site; other site 1138382008106 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138382008107 motif 1; other site 1138382008108 dimer interface [polypeptide binding]; other site 1138382008109 active site 1138382008110 motif 2; other site 1138382008111 motif 3; other site 1138382008112 Predicted esterase [General function prediction only]; Region: COG0627 1138382008113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382008114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382008115 hypothetical protein; Provisional; Region: PRK07877 1138382008116 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1138382008117 ATP binding site [chemical binding]; other site 1138382008118 substrate interface [chemical binding]; other site 1138382008119 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138382008120 dimer interface [polypeptide binding]; other site 1138382008121 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138382008122 Cytochrome P450; Region: p450; cl12078 1138382008123 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382008124 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138382008125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138382008126 metal binding site [ion binding]; metal-binding site 1138382008127 active site 1138382008128 I-site; other site 1138382008129 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138382008130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382008131 S-adenosylmethionine binding site [chemical binding]; other site 1138382008132 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138382008133 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1138382008134 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138382008135 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138382008136 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1138382008137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382008138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138382008139 Ligand Binding Site [chemical binding]; other site 1138382008140 Predicted membrane protein [Function unknown]; Region: COG5305 1138382008141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382008142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138382008143 putative substrate translocation pore; other site 1138382008144 excinuclease ABC subunit B; Provisional; Region: PRK05298 1138382008145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382008146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382008147 nucleotide binding region [chemical binding]; other site 1138382008148 ATP-binding site [chemical binding]; other site 1138382008149 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1138382008150 UvrB/uvrC motif; Region: UVR; pfam02151 1138382008151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382008152 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138382008153 active site 1138382008154 ATP binding site [chemical binding]; other site 1138382008155 substrate binding site [chemical binding]; other site 1138382008156 activation loop (A-loop); other site 1138382008157 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382008158 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382008159 phosphopeptide binding site; other site 1138382008160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382008161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382008162 phosphopeptide binding site; other site 1138382008163 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138382008164 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138382008165 Walker A/P-loop; other site 1138382008166 ATP binding site [chemical binding]; other site 1138382008167 Q-loop/lid; other site 1138382008168 ABC transporter signature motif; other site 1138382008169 Walker B; other site 1138382008170 D-loop; other site 1138382008171 H-loop/switch region; other site 1138382008172 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138382008173 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138382008174 Protein of unknown function (DUF402); Region: DUF402; cl00979 1138382008175 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1138382008176 CheB methylesterase; Region: CheB_methylest; pfam01339 1138382008177 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1138382008178 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1138382008179 active site 1138382008180 DNA binding site [nucleotide binding] 1138382008181 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1138382008182 DNA binding site [nucleotide binding] 1138382008183 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1138382008184 nucleotide binding site [chemical binding]; other site 1138382008185 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138382008186 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 1138382008187 DNA binding site [nucleotide binding] 1138382008188 catalytic residue [active] 1138382008189 H2TH interface [polypeptide binding]; other site 1138382008190 putative catalytic residues [active] 1138382008191 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138382008192 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138382008193 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1138382008194 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1138382008195 CoA-binding site [chemical binding]; other site 1138382008196 ATP-binding [chemical binding]; other site 1138382008197 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1138382008198 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1138382008199 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1138382008200 RNA binding site [nucleotide binding]; other site 1138382008201 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1138382008202 RNA binding site [nucleotide binding]; other site 1138382008203 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138382008204 RNA binding site [nucleotide binding]; other site 1138382008205 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1138382008206 RNA binding site [nucleotide binding]; other site 1138382008207 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138382008208 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138382008209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382008210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382008211 5'-3' exonuclease; Region: 53EXOc; smart00475 1138382008212 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138382008213 active site 1138382008214 metal binding site 1 [ion binding]; metal-binding site 1138382008215 putative 5' ssDNA interaction site; other site 1138382008216 metal binding site 3; metal-binding site 1138382008217 metal binding site 2 [ion binding]; metal-binding site 1138382008218 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138382008219 putative DNA binding site [nucleotide binding]; other site 1138382008220 putative metal binding site [ion binding]; other site 1138382008221 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1138382008222 DNA polymerase I; Provisional; Region: PRK05755 1138382008223 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1138382008224 active site 1138382008225 DNA binding site [nucleotide binding] 1138382008226 catalytic site [active] 1138382008227 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138382008228 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382008229 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382008230 lipid-transfer protein; Provisional; Region: PRK06059 1138382008231 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382008232 active site 1138382008233 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1138382008234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382008235 active site 1138382008236 phosphorylation site [posttranslational modification] 1138382008237 intermolecular recognition site; other site 1138382008238 dimerization interface [polypeptide binding]; other site 1138382008239 ANTAR domain; Region: ANTAR; pfam03861 1138382008240 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138382008241 cyclase homology domain; Region: CHD; cd07302 1138382008242 nucleotidyl binding site; other site 1138382008243 metal binding site [ion binding]; metal-binding site 1138382008244 dimer interface [polypeptide binding]; other site 1138382008245 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1138382008246 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1138382008247 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1138382008248 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1138382008249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382008250 Walker A/P-loop; other site 1138382008251 ATP binding site [chemical binding]; other site 1138382008252 ABC transporter; Region: ABC_tran; pfam00005 1138382008253 Q-loop/lid; other site 1138382008254 ABC transporter signature motif; other site 1138382008255 Walker B; other site 1138382008256 D-loop; other site 1138382008257 H-loop/switch region; other site 1138382008258 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1138382008259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382008260 Walker A/P-loop; other site 1138382008261 ATP binding site [chemical binding]; other site 1138382008262 Q-loop/lid; other site 1138382008263 ABC transporter signature motif; other site 1138382008264 Walker B; other site 1138382008265 D-loop; other site 1138382008266 H-loop/switch region; other site 1138382008267 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138382008268 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138382008269 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138382008270 active site 1138382008271 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138382008272 catalytic triad [active] 1138382008273 dimer interface [polypeptide binding]; other site 1138382008274 pyruvate kinase; Provisional; Region: PRK06247 1138382008275 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1138382008276 domain interfaces; other site 1138382008277 active site 1138382008278 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1138382008279 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1138382008280 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1138382008281 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1138382008282 substrate binding site [chemical binding]; other site 1138382008283 active site 1138382008284 catalytic residues [active] 1138382008285 heterodimer interface [polypeptide binding]; other site 1138382008286 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1138382008287 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1138382008288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382008289 catalytic residue [active] 1138382008290 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1138382008291 active site 1138382008292 ribulose/triose binding site [chemical binding]; other site 1138382008293 phosphate binding site [ion binding]; other site 1138382008294 substrate (anthranilate) binding pocket [chemical binding]; other site 1138382008295 product (indole) binding pocket [chemical binding]; other site 1138382008296 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1138382008297 anthranilate synthase component I; Provisional; Region: PRK13571 1138382008298 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1138382008299 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138382008300 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138382008301 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138382008302 catalytic triad [active] 1138382008303 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1138382008304 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1138382008305 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1138382008306 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1138382008307 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138382008308 substrate binding site [chemical binding]; other site 1138382008309 glutamase interaction surface [polypeptide binding]; other site 1138382008310 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138382008311 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1138382008312 active site 1138382008313 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1138382008314 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138382008315 catalytic residues [active] 1138382008316 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1138382008317 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1138382008318 putative active site [active] 1138382008319 oxyanion strand; other site 1138382008320 catalytic triad [active] 1138382008321 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1138382008322 4-fold oligomerization interface [polypeptide binding]; other site 1138382008323 putative active site pocket [active] 1138382008324 metal binding residues [ion binding]; metal-binding site 1138382008325 3-fold/trimer interface [polypeptide binding]; other site 1138382008326 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1138382008327 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382008328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382008329 homodimer interface [polypeptide binding]; other site 1138382008330 catalytic residue [active] 1138382008331 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1138382008332 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1138382008333 NAD binding site [chemical binding]; other site 1138382008334 dimerization interface [polypeptide binding]; other site 1138382008335 product binding site; other site 1138382008336 substrate binding site [chemical binding]; other site 1138382008337 zinc binding site [ion binding]; other site 1138382008338 catalytic residues [active] 1138382008339 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138382008340 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1138382008341 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1138382008342 dimerization interface [polypeptide binding]; other site 1138382008343 active site 1138382008344 L-aspartate oxidase; Provisional; Region: PRK07804 1138382008345 L-aspartate oxidase; Provisional; Region: PRK06175 1138382008346 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138382008347 quinolinate synthetase; Provisional; Region: PRK09375 1138382008348 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1138382008349 nudix motif; other site 1138382008350 Secretory lipase; Region: LIP; pfam03583 1138382008351 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1138382008352 biotin synthase; Validated; Region: PRK06256 1138382008353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382008354 FeS/SAM binding site; other site 1138382008355 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1138382008356 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138382008357 dimerization interface [polypeptide binding]; other site 1138382008358 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138382008359 cyclase homology domain; Region: CHD; cd07302 1138382008360 nucleotidyl binding site; other site 1138382008361 metal binding site [ion binding]; metal-binding site 1138382008362 dimer interface [polypeptide binding]; other site 1138382008363 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138382008364 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138382008365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138382008366 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138382008367 ligand binding site [chemical binding]; other site 1138382008368 flexible hinge region; other site 1138382008369 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138382008370 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1138382008371 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1138382008372 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1138382008373 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1138382008374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382008375 catalytic residue [active] 1138382008376 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1138382008377 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138382008378 inhibitor-cofactor binding pocket; inhibition site 1138382008379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382008380 catalytic residue [active] 1138382008381 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138382008382 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138382008383 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382008384 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1138382008385 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1138382008386 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1138382008387 active site 1138382008388 catalytic site [active] 1138382008389 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1138382008390 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1138382008391 active site 1138382008392 catalytic site [active] 1138382008393 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1138382008394 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1138382008395 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1138382008396 catalytic site [active] 1138382008397 active site 1138382008398 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138382008399 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1138382008400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382008401 DNA-binding site [nucleotide binding]; DNA binding site 1138382008402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382008403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382008404 homodimer interface [polypeptide binding]; other site 1138382008405 catalytic residue [active] 1138382008406 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138382008407 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1138382008408 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138382008409 active site 1138382008410 threonine dehydratase; Validated; Region: PRK08639 1138382008411 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1138382008412 tetramer interface [polypeptide binding]; other site 1138382008413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382008414 catalytic residue [active] 1138382008415 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1138382008416 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382008417 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1138382008418 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138382008419 putative acyl-acceptor binding pocket; other site 1138382008420 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138382008421 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138382008422 acyl-activating enzyme (AAE) consensus motif; other site 1138382008423 putative AMP binding site [chemical binding]; other site 1138382008424 putative active site [active] 1138382008425 putative CoA binding site [chemical binding]; other site 1138382008426 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382008427 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138382008428 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1138382008429 DNA binding residues [nucleotide binding] 1138382008430 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1138382008431 putative dimer interface [polypeptide binding]; other site 1138382008432 putative metal binding residues [ion binding]; other site 1138382008433 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138382008434 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1138382008435 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1138382008436 active site 1138382008437 PHP Thumb interface [polypeptide binding]; other site 1138382008438 metal binding site [ion binding]; metal-binding site 1138382008439 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138382008440 generic binding surface II; other site 1138382008441 generic binding surface I; other site 1138382008442 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382008443 hydrophobic ligand binding site; other site 1138382008444 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138382008445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382008446 NAD(P) binding site [chemical binding]; other site 1138382008447 active site 1138382008448 classical (c) SDRs; Region: SDR_c; cd05233 1138382008449 NAD(P) binding site [chemical binding]; other site 1138382008450 active site 1138382008451 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1138382008452 apolar tunnel; other site 1138382008453 heme binding site [chemical binding]; other site 1138382008454 dimerization interface [polypeptide binding]; other site 1138382008455 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382008456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382008457 S-adenosylmethionine binding site [chemical binding]; other site 1138382008458 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1138382008459 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1138382008460 active site 1138382008461 lipoprotein signal peptidase; Provisional; Region: PRK14764 1138382008462 lipoprotein signal peptidase; Provisional; Region: PRK14787 1138382008463 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1138382008464 active site 1138382008465 homodimer interface [polypeptide binding]; other site 1138382008466 homotetramer interface [polypeptide binding]; other site 1138382008467 DNA polymerase IV; Provisional; Region: PRK03348 1138382008468 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138382008469 active site 1138382008470 DNA binding site [nucleotide binding] 1138382008471 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1138382008472 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138382008473 HIGH motif; other site 1138382008474 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138382008475 active site 1138382008476 KMSKS motif; other site 1138382008477 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1138382008478 tRNA binding surface [nucleotide binding]; other site 1138382008479 anticodon binding site; other site 1138382008480 Nitronate monooxygenase; Region: NMO; pfam03060 1138382008481 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382008482 FMN binding site [chemical binding]; other site 1138382008483 substrate binding site [chemical binding]; other site 1138382008484 putative catalytic residue [active] 1138382008485 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382008486 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382008487 Condensation domain; Region: Condensation; pfam00668 1138382008488 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008489 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382008490 acyl-activating enzyme (AAE) consensus motif; other site 1138382008491 AMP binding site [chemical binding]; other site 1138382008492 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008493 Condensation domain; Region: Condensation; pfam00668 1138382008494 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008495 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008496 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008497 acyl-activating enzyme (AAE) consensus motif; other site 1138382008498 AMP binding site [chemical binding]; other site 1138382008499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008500 peptide synthase; Provisional; Region: PRK12467 1138382008501 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008502 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008503 acyl-activating enzyme (AAE) consensus motif; other site 1138382008504 AMP binding site [chemical binding]; other site 1138382008505 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008506 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008507 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008508 acyl-activating enzyme (AAE) consensus motif; other site 1138382008509 AMP binding site [chemical binding]; other site 1138382008510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008511 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382008512 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008513 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008514 acyl-activating enzyme (AAE) consensus motif; other site 1138382008515 AMP binding site [chemical binding]; other site 1138382008516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008517 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008518 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008519 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008520 acyl-activating enzyme (AAE) consensus motif; other site 1138382008521 AMP binding site [chemical binding]; other site 1138382008522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008523 Condensation domain; Region: Condensation; pfam00668 1138382008524 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008525 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008526 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008527 acyl-activating enzyme (AAE) consensus motif; other site 1138382008528 AMP binding site [chemical binding]; other site 1138382008529 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008530 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138382008531 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138382008532 putative NAD(P) binding site [chemical binding]; other site 1138382008533 active site 1138382008534 putative substrate binding site [chemical binding]; other site 1138382008535 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008536 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382008537 acyl-activating enzyme (AAE) consensus motif; other site 1138382008538 AMP binding site [chemical binding]; other site 1138382008539 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008540 Condensation domain; Region: Condensation; pfam00668 1138382008541 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382008542 Condensation domain; Region: Condensation; pfam00668 1138382008543 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008544 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008545 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008546 acyl-activating enzyme (AAE) consensus motif; other site 1138382008547 AMP binding site [chemical binding]; other site 1138382008548 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008549 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138382008550 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138382008551 putative NAD(P) binding site [chemical binding]; other site 1138382008552 active site 1138382008553 putative substrate binding site [chemical binding]; other site 1138382008554 Condensation domain; Region: Condensation; pfam00668 1138382008555 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008556 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382008557 acyl-activating enzyme (AAE) consensus motif; other site 1138382008558 AMP binding site [chemical binding]; other site 1138382008559 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008560 Condensation domain; Region: Condensation; pfam00668 1138382008561 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382008562 Condensation domain; Region: Condensation; pfam00668 1138382008563 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008564 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008565 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008566 acyl-activating enzyme (AAE) consensus motif; other site 1138382008567 AMP binding site [chemical binding]; other site 1138382008568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008569 Condensation domain; Region: Condensation; pfam00668 1138382008570 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382008571 Condensation domain; Region: Condensation; pfam00668 1138382008572 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008573 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008574 MbtH-like protein; Region: MbtH; pfam03621 1138382008575 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382008576 MMPL family; Region: MMPL; pfam03176 1138382008577 potential frameshift: common BLAST hit: gi|118463450|ref|YP_882431.1| Mmp14A protein 1138382008578 MMPL family; Region: MMPL; pfam03176 1138382008579 MMPL family; Region: MMPL; pfam03176 1138382008580 MMPL family; Region: MMPL; pfam03176 1138382008581 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1138382008582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382008583 Walker A/P-loop; other site 1138382008584 ATP binding site [chemical binding]; other site 1138382008585 Q-loop/lid; other site 1138382008586 ABC transporter signature motif; other site 1138382008587 Walker B; other site 1138382008588 D-loop; other site 1138382008589 H-loop/switch region; other site 1138382008590 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382008591 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138382008592 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138382008593 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382008594 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138382008595 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1138382008596 metal-binding site 1138382008597 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1138382008598 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1138382008599 NADP binding site [chemical binding]; other site 1138382008600 active site 1138382008601 putative substrate binding site [chemical binding]; other site 1138382008602 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1138382008603 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1138382008604 NADP-binding site; other site 1138382008605 homotetramer interface [polypeptide binding]; other site 1138382008606 substrate binding site [chemical binding]; other site 1138382008607 homodimer interface [polypeptide binding]; other site 1138382008608 active site 1138382008609 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1138382008610 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1138382008611 substrate binding site; other site 1138382008612 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1138382008613 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1138382008614 NAD binding site [chemical binding]; other site 1138382008615 homotetramer interface [polypeptide binding]; other site 1138382008616 homodimer interface [polypeptide binding]; other site 1138382008617 substrate binding site [chemical binding]; other site 1138382008618 active site 1138382008619 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1138382008620 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1138382008621 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382008622 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1138382008623 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1138382008624 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1138382008625 inhibitor-cofactor binding pocket; inhibition site 1138382008626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382008627 catalytic residue [active] 1138382008628 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1138382008629 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1138382008630 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1138382008631 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1138382008632 NADP-binding site; other site 1138382008633 homotetramer interface [polypeptide binding]; other site 1138382008634 substrate binding site [chemical binding]; other site 1138382008635 homodimer interface [polypeptide binding]; other site 1138382008636 active site 1138382008637 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382008638 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1138382008639 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138382008640 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138382008641 homodimer interface [polypeptide binding]; other site 1138382008642 active site 1138382008643 TDP-binding site; other site 1138382008644 acceptor substrate-binding pocket; other site 1138382008645 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138382008646 classical (c) SDRs; Region: SDR_c; cd05233 1138382008647 NAD(P) binding site [chemical binding]; other site 1138382008648 active site 1138382008649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382008650 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 1138382008651 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138382008652 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138382008653 homodimer interface [polypeptide binding]; other site 1138382008654 active site 1138382008655 TDP-binding site; other site 1138382008656 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138382008657 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138382008658 homodimer interface [polypeptide binding]; other site 1138382008659 active site 1138382008660 TDP-binding site; other site 1138382008661 acceptor substrate-binding pocket; other site 1138382008662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382008663 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382008664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382008665 NAD(P) binding site [chemical binding]; other site 1138382008666 active site 1138382008667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1138382008668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1138382008669 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382008670 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382008671 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382008672 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1138382008673 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1138382008674 Walker A; other site 1138382008675 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1138382008676 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1138382008677 active site 1138382008678 substrate binding site [chemical binding]; other site 1138382008679 coenzyme B12 binding site [chemical binding]; other site 1138382008680 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1138382008681 B12 binding site [chemical binding]; other site 1138382008682 cobalt ligand [ion binding]; other site 1138382008683 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1138382008684 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1138382008685 heterodimer interface [polypeptide binding]; other site 1138382008686 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1138382008687 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138382008688 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138382008689 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1138382008690 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1138382008691 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138382008692 putative di-iron ligands [ion binding]; other site 1138382008693 Condensation domain; Region: Condensation; pfam00668 1138382008694 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008695 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138382008696 acyl-activating enzyme (AAE) consensus motif; other site 1138382008697 AMP binding site [chemical binding]; other site 1138382008698 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008699 Condensation domain; Region: Condensation; pfam00668 1138382008700 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382008701 Condensation domain; Region: Condensation; pfam00668 1138382008702 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008703 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138382008705 acyl-activating enzyme (AAE) consensus motif; other site 1138382008706 AMP binding site [chemical binding]; other site 1138382008707 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382008708 Condensation domain; Region: Condensation; pfam00668 1138382008709 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138382008710 Condensation domain; Region: Condensation; pfam00668 1138382008711 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138382008712 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138382008713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382008714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1138382008715 dimerization interface [polypeptide binding]; other site 1138382008716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382008717 dimer interface [polypeptide binding]; other site 1138382008718 phosphorylation site [posttranslational modification] 1138382008719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382008720 Mg2+ binding site [ion binding]; other site 1138382008721 G-X-G motif; other site 1138382008722 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382008723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382008724 active site 1138382008725 phosphorylation site [posttranslational modification] 1138382008726 intermolecular recognition site; other site 1138382008727 dimerization interface [polypeptide binding]; other site 1138382008728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382008729 DNA binding site [nucleotide binding] 1138382008730 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1138382008731 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138382008732 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138382008733 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1138382008734 ferrochelatase; Reviewed; Region: hemH; PRK00035 1138382008735 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1138382008736 C-terminal domain interface [polypeptide binding]; other site 1138382008737 active site 1138382008738 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1138382008739 active site 1138382008740 N-terminal domain interface [polypeptide binding]; other site 1138382008741 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1138382008742 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1138382008743 NAD binding site [chemical binding]; other site 1138382008744 homotetramer interface [polypeptide binding]; other site 1138382008745 homodimer interface [polypeptide binding]; other site 1138382008746 substrate binding site [chemical binding]; other site 1138382008747 active site 1138382008748 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1138382008749 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138382008750 NAD(P) binding site [chemical binding]; other site 1138382008751 homotetramer interface [polypeptide binding]; other site 1138382008752 homodimer interface [polypeptide binding]; other site 1138382008753 active site 1138382008754 hypothetical protein; Provisional; Region: PRK13685 1138382008755 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1138382008756 metal ion-dependent adhesion site (MIDAS); other site 1138382008757 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138382008758 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138382008759 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138382008760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382008761 Walker A motif; other site 1138382008762 ATP binding site [chemical binding]; other site 1138382008763 Walker B motif; other site 1138382008764 arginine finger; other site 1138382008765 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138382008766 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138382008767 potential frameshift: common BLAST hit: gi|118465185|ref|YP_882483.1| invasion protein 1138382008768 NlpC/P60 family; Region: NLPC_P60; cl17555 1138382008769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1138382008770 aconitate hydratase; Validated; Region: PRK09277 1138382008771 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138382008772 substrate binding site [chemical binding]; other site 1138382008773 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138382008774 ligand binding site [chemical binding]; other site 1138382008775 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1138382008776 substrate binding site [chemical binding]; other site 1138382008777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382008778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382008779 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138382008780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382008781 Walker A/P-loop; other site 1138382008782 ATP binding site [chemical binding]; other site 1138382008783 Q-loop/lid; other site 1138382008784 ABC transporter signature motif; other site 1138382008785 Walker B; other site 1138382008786 D-loop; other site 1138382008787 H-loop/switch region; other site 1138382008788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138382008789 enoyl-CoA hydratase; Provisional; Region: PRK05864 1138382008790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382008791 substrate binding site [chemical binding]; other site 1138382008792 oxyanion hole (OAH) forming residues; other site 1138382008793 trimer interface [polypeptide binding]; other site 1138382008794 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138382008795 catalytic residues [active] 1138382008796 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138382008797 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138382008798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382008799 active site 1138382008800 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138382008801 Transport protein; Region: actII; TIGR00833 1138382008802 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382008803 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1138382008804 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1138382008805 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1138382008806 trimerization site [polypeptide binding]; other site 1138382008807 active site 1138382008808 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138382008809 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1138382008810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382008811 catalytic residue [active] 1138382008812 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1138382008813 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1138382008814 Walker A/P-loop; other site 1138382008815 ATP binding site [chemical binding]; other site 1138382008816 Q-loop/lid; other site 1138382008817 ABC transporter signature motif; other site 1138382008818 Walker B; other site 1138382008819 D-loop; other site 1138382008820 H-loop/switch region; other site 1138382008821 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1138382008822 FeS assembly protein SufD; Region: sufD; TIGR01981 1138382008823 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1138382008824 FeS assembly protein SufB; Region: sufB; TIGR01980 1138382008825 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138382008826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382008827 putative DNA binding site [nucleotide binding]; other site 1138382008828 putative Zn2+ binding site [ion binding]; other site 1138382008829 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138382008830 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138382008831 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138382008832 Walker A/P-loop; other site 1138382008833 ATP binding site [chemical binding]; other site 1138382008834 Q-loop/lid; other site 1138382008835 ABC transporter signature motif; other site 1138382008836 Walker B; other site 1138382008837 D-loop; other site 1138382008838 H-loop/switch region; other site 1138382008839 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382008840 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1138382008841 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1138382008842 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1138382008843 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1138382008844 NADP binding site [chemical binding]; other site 1138382008845 dimer interface [polypeptide binding]; other site 1138382008846 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1138382008847 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138382008848 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1138382008849 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1138382008850 TPP-binding site [chemical binding]; other site 1138382008851 dimer interface [polypeptide binding]; other site 1138382008852 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138382008853 PYR/PP interface [polypeptide binding]; other site 1138382008854 dimer interface [polypeptide binding]; other site 1138382008855 TPP binding site [chemical binding]; other site 1138382008856 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138382008857 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1138382008858 putative active site [active] 1138382008859 transaldolase; Provisional; Region: PRK03903 1138382008860 catalytic residue [active] 1138382008861 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1138382008862 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138382008863 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138382008864 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1138382008865 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1138382008866 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1138382008867 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1138382008868 putative active site [active] 1138382008869 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1138382008870 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1138382008871 putative active site [active] 1138382008872 Zn binding site [ion binding]; other site 1138382008873 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382008874 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382008875 active site 1138382008876 catalytic tetrad [active] 1138382008877 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1138382008878 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1138382008879 Preprotein translocase SecG subunit; Region: SecG; cl09123 1138382008880 triosephosphate isomerase; Provisional; Region: PRK14567 1138382008881 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1138382008882 substrate binding site [chemical binding]; other site 1138382008883 dimer interface [polypeptide binding]; other site 1138382008884 catalytic triad [active] 1138382008885 Phosphoglycerate kinase; Region: PGK; pfam00162 1138382008886 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1138382008887 substrate binding site [chemical binding]; other site 1138382008888 hinge regions; other site 1138382008889 ADP binding site [chemical binding]; other site 1138382008890 catalytic site [active] 1138382008891 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1138382008892 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1138382008893 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1138382008894 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138382008895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382008896 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138382008897 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382008898 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382008899 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138382008900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382008901 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138382008902 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382008903 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138382008904 putative acyl-acceptor binding pocket; other site 1138382008905 acyl-CoA synthetase; Provisional; Region: PRK13382 1138382008906 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382008907 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382008908 acyl-activating enzyme (AAE) consensus motif; other site 1138382008909 putative AMP binding site [chemical binding]; other site 1138382008910 putative active site [active] 1138382008911 putative CoA binding site [chemical binding]; other site 1138382008912 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382008913 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382008914 substrate binding pocket [chemical binding]; other site 1138382008915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382008916 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382008917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382008918 active site 1138382008919 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382008920 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382008921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1138382008922 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1138382008923 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1138382008924 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1138382008925 phosphate binding site [ion binding]; other site 1138382008926 putative substrate binding pocket [chemical binding]; other site 1138382008927 dimer interface [polypeptide binding]; other site 1138382008928 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1138382008929 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1138382008930 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138382008931 GIY-YIG motif/motif A; other site 1138382008932 active site 1138382008933 catalytic site [active] 1138382008934 putative DNA binding site [nucleotide binding]; other site 1138382008935 metal binding site [ion binding]; metal-binding site 1138382008936 UvrB/uvrC motif; Region: UVR; pfam02151 1138382008937 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1138382008938 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138382008939 Cupin superfamily protein; Region: Cupin_4; pfam08007 1138382008940 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382008941 PPE family; Region: PPE; pfam00823 1138382008942 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138382008943 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1138382008944 homopentamer interface [polypeptide binding]; other site 1138382008945 active site 1138382008946 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1138382008947 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1138382008948 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1138382008949 dimerization interface [polypeptide binding]; other site 1138382008950 active site 1138382008951 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1138382008952 Lumazine binding domain; Region: Lum_binding; pfam00677 1138382008953 Lumazine binding domain; Region: Lum_binding; pfam00677 1138382008954 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1138382008955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382008956 putative substrate translocation pore; other site 1138382008957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382008958 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1138382008959 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1138382008960 catalytic motif [active] 1138382008961 Zn binding site [ion binding]; other site 1138382008962 RibD C-terminal domain; Region: RibD_C; pfam01872 1138382008963 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1138382008964 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1138382008965 substrate binding site [chemical binding]; other site 1138382008966 hexamer interface [polypeptide binding]; other site 1138382008967 metal binding site [ion binding]; metal-binding site 1138382008968 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1138382008969 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1138382008970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382008971 S-adenosylmethionine binding site [chemical binding]; other site 1138382008972 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1138382008973 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1138382008974 putative active site [active] 1138382008975 substrate binding site [chemical binding]; other site 1138382008976 putative cosubstrate binding site; other site 1138382008977 catalytic site [active] 1138382008978 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1138382008979 substrate binding site [chemical binding]; other site 1138382008980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382008981 S-adenosylmethionine binding site [chemical binding]; other site 1138382008982 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382008983 MarR family; Region: MarR; pfam01047 1138382008984 primosome assembly protein PriA; Provisional; Region: PRK14873 1138382008985 Predicted membrane protein [Function unknown]; Region: COG3714 1138382008986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382008987 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382008988 substrate binding pocket [chemical binding]; other site 1138382008989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382008990 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382008991 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138382008992 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1138382008993 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1138382008994 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1138382008995 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1138382008996 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1138382008997 Flavoprotein; Region: Flavoprotein; pfam02441 1138382008998 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1138382008999 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1138382009000 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1138382009001 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1138382009002 catalytic site [active] 1138382009003 G-X2-G-X-G-K; other site 1138382009004 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1138382009005 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138382009006 DNA binding residues [nucleotide binding] 1138382009007 TOBE domain; Region: TOBE; cl01440 1138382009008 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1138382009009 active site 1138382009010 dimer interface [polypeptide binding]; other site 1138382009011 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1138382009012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382009013 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382009014 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1138382009015 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382009016 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382009017 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1138382009018 IMP binding site; other site 1138382009019 dimer interface [polypeptide binding]; other site 1138382009020 interdomain contacts; other site 1138382009021 partial ornithine binding site; other site 1138382009022 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1138382009023 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1138382009024 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1138382009025 catalytic site [active] 1138382009026 subunit interface [polypeptide binding]; other site 1138382009027 dihydroorotase; Validated; Region: pyrC; PRK09357 1138382009028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382009029 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1138382009030 active site 1138382009031 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138382009032 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1138382009033 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138382009034 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1138382009035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382009036 active site 1138382009037 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382009038 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382009039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138382009040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138382009041 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1138382009042 L-aspartate oxidase; Provisional; Region: PRK06175 1138382009043 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138382009044 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138382009045 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138382009046 Walker A/P-loop; other site 1138382009047 ATP binding site [chemical binding]; other site 1138382009048 Q-loop/lid; other site 1138382009049 ABC transporter signature motif; other site 1138382009050 Walker B; other site 1138382009051 D-loop; other site 1138382009052 H-loop/switch region; other site 1138382009053 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138382009054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382009055 dimer interface [polypeptide binding]; other site 1138382009056 conserved gate region; other site 1138382009057 putative PBP binding loops; other site 1138382009058 ABC-ATPase subunit interface; other site 1138382009059 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1138382009060 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1138382009061 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1138382009062 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138382009063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382009064 DNA-binding site [nucleotide binding]; DNA binding site 1138382009065 UTRA domain; Region: UTRA; pfam07702 1138382009066 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1138382009067 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382009068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382009069 catalytic residue [active] 1138382009070 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1138382009071 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1138382009072 putative RNA binding site [nucleotide binding]; other site 1138382009073 elongation factor P; Validated; Region: PRK00529 1138382009074 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1138382009075 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1138382009076 RNA binding site [nucleotide binding]; other site 1138382009077 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1138382009078 RNA binding site [nucleotide binding]; other site 1138382009079 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138382009080 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138382009081 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138382009082 active site 1138382009083 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1138382009084 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1138382009085 trimer interface [polypeptide binding]; other site 1138382009086 active site 1138382009087 dimer interface [polypeptide binding]; other site 1138382009088 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1138382009089 active site 1138382009090 dimer interface [polypeptide binding]; other site 1138382009091 metal binding site [ion binding]; metal-binding site 1138382009092 shikimate kinase; Reviewed; Region: aroK; PRK00131 1138382009093 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1138382009094 ADP binding site [chemical binding]; other site 1138382009095 magnesium binding site [ion binding]; other site 1138382009096 putative shikimate binding site; other site 1138382009097 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1138382009098 chorismate synthase; Validated; Region: PRK05382 1138382009099 Tetramer interface [polypeptide binding]; other site 1138382009100 active site 1138382009101 FMN-binding site [chemical binding]; other site 1138382009102 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1138382009103 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1138382009104 active site 1138382009105 dimer interface [polypeptide binding]; other site 1138382009106 non-prolyl cis peptide bond; other site 1138382009107 insertion regions; other site 1138382009108 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1138382009109 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1138382009110 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1138382009111 shikimate binding site; other site 1138382009112 NAD(P) binding site [chemical binding]; other site 1138382009113 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1138382009114 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1138382009115 dimerization interface [polypeptide binding]; other site 1138382009116 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1138382009117 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1138382009118 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1138382009119 motif 1; other site 1138382009120 active site 1138382009121 motif 2; other site 1138382009122 motif 3; other site 1138382009123 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1138382009124 DHHA1 domain; Region: DHHA1; pfam02272 1138382009125 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1138382009126 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1138382009127 recombination factor protein RarA; Reviewed; Region: PRK13342 1138382009128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382009129 Walker A motif; other site 1138382009130 ATP binding site [chemical binding]; other site 1138382009131 Walker B motif; other site 1138382009132 arginine finger; other site 1138382009133 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1138382009134 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1138382009135 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1138382009136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138382009137 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138382009138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1138382009139 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1138382009140 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138382009141 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138382009142 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138382009143 Protein of unknown function (DUF419); Region: DUF419; cl15265 1138382009144 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1138382009145 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382009146 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1138382009147 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1138382009148 dimer interface [polypeptide binding]; other site 1138382009149 anticodon binding site; other site 1138382009150 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1138382009151 homodimer interface [polypeptide binding]; other site 1138382009152 motif 1; other site 1138382009153 active site 1138382009154 motif 2; other site 1138382009155 GAD domain; Region: GAD; pfam02938 1138382009156 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138382009157 active site 1138382009158 motif 3; other site 1138382009159 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1138382009160 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1138382009161 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1138382009162 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138382009163 putative hydrophobic ligand binding site [chemical binding]; other site 1138382009164 protein interface [polypeptide binding]; other site 1138382009165 gate; other site 1138382009166 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1138382009167 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138382009168 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1138382009169 inhibitor site; inhibition site 1138382009170 active site 1138382009171 dimer interface [polypeptide binding]; other site 1138382009172 catalytic residue [active] 1138382009173 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1138382009174 intersubunit interface [polypeptide binding]; other site 1138382009175 active site 1138382009176 Zn2+ binding site [ion binding]; other site 1138382009177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382009178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382009179 non-specific DNA binding site [nucleotide binding]; other site 1138382009180 salt bridge; other site 1138382009181 sequence-specific DNA binding site [nucleotide binding]; other site 1138382009182 Cupin domain; Region: Cupin_2; pfam07883 1138382009183 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138382009184 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138382009185 active site 1138382009186 metal binding site [ion binding]; metal-binding site 1138382009187 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1138382009188 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1138382009189 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382009190 hydrophobic ligand binding site; other site 1138382009191 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382009192 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382009193 active site 1138382009194 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1138382009195 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1138382009196 dimer interface [polypeptide binding]; other site 1138382009197 motif 1; other site 1138382009198 active site 1138382009199 motif 2; other site 1138382009200 motif 3; other site 1138382009201 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1138382009202 anticodon binding site; other site 1138382009203 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138382009204 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138382009205 active site 1138382009206 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1138382009207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138382009208 Zn2+ binding site [ion binding]; other site 1138382009209 Mg2+ binding site [ion binding]; other site 1138382009210 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1138382009211 synthetase active site [active] 1138382009212 NTP binding site [chemical binding]; other site 1138382009213 metal binding site [ion binding]; metal-binding site 1138382009214 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1138382009215 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1138382009216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382009217 active site 1138382009218 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138382009219 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138382009220 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1138382009221 Protein export membrane protein; Region: SecD_SecF; pfam02355 1138382009222 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1138382009223 Protein export membrane protein; Region: SecD_SecF; cl14618 1138382009224 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1138382009225 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1138382009226 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138382009227 inhibitor-cofactor binding pocket; inhibition site 1138382009228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382009229 catalytic residue [active] 1138382009230 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138382009231 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382009232 acyl-activating enzyme (AAE) consensus motif; other site 1138382009233 AMP binding site [chemical binding]; other site 1138382009234 active site 1138382009235 CoA binding site [chemical binding]; other site 1138382009236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382009237 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138382009238 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138382009239 putative NAD(P) binding site [chemical binding]; other site 1138382009240 active site 1138382009241 putative substrate binding site [chemical binding]; other site 1138382009242 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1138382009243 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1138382009244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382009245 Walker A motif; other site 1138382009246 ATP binding site [chemical binding]; other site 1138382009247 Walker B motif; other site 1138382009248 arginine finger; other site 1138382009249 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1138382009250 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1138382009251 RuvA N terminal domain; Region: RuvA_N; pfam01330 1138382009252 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1138382009253 active site 1138382009254 putative DNA-binding cleft [nucleotide binding]; other site 1138382009255 dimer interface [polypeptide binding]; other site 1138382009256 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1138382009257 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1138382009258 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1138382009259 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1138382009260 spermidine synthase; Provisional; Region: PRK03612 1138382009261 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1138382009262 hypothetical protein; Validated; Region: PRK00110 1138382009263 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1138382009264 predicted active site [active] 1138382009265 catalytic triad [active] 1138382009266 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138382009267 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138382009268 active site 1138382009269 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138382009270 catalytic triad [active] 1138382009271 dimer interface [polypeptide binding]; other site 1138382009272 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1138382009273 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1138382009274 active site 1138382009275 multimer interface [polypeptide binding]; other site 1138382009276 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1138382009277 nudix motif; other site 1138382009278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382009279 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382009280 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1138382009281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1138382009282 putative acyl-acceptor binding pocket; other site 1138382009283 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138382009284 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1138382009285 nucleotide binding site/active site [active] 1138382009286 HIT family signature motif; other site 1138382009287 catalytic residue [active] 1138382009288 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1138382009289 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1138382009290 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1138382009291 active site 1138382009292 dimer interface [polypeptide binding]; other site 1138382009293 motif 1; other site 1138382009294 motif 2; other site 1138382009295 motif 3; other site 1138382009296 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1138382009297 anticodon binding site; other site 1138382009298 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1138382009299 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382009300 CoenzymeA binding site [chemical binding]; other site 1138382009301 subunit interaction site [polypeptide binding]; other site 1138382009302 PHB binding site; other site 1138382009303 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382009304 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382009305 active site 1138382009306 catalytic tetrad [active] 1138382009307 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1138382009308 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138382009309 putative DNA binding site [nucleotide binding]; other site 1138382009310 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138382009311 putative Zn2+ binding site [ion binding]; other site 1138382009312 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382009313 FMN binding site [chemical binding]; other site 1138382009314 substrate binding site [chemical binding]; other site 1138382009315 putative catalytic residue [active] 1138382009316 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1138382009317 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138382009318 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138382009319 putative DNA binding site [nucleotide binding]; other site 1138382009320 putative Zn2+ binding site [ion binding]; other site 1138382009321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382009322 S-adenosylmethionine binding site [chemical binding]; other site 1138382009323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382009324 potential frameshift: common BLAST hit: gi|54025276|ref|YP_119518.1| transposase 1138382009325 Integrase core domain; Region: rve; pfam00665 1138382009326 Integrase core domain; Region: rve_3; pfam13683 1138382009327 Homeodomain-like domain; Region: HTH_23; cl17451 1138382009328 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1138382009329 tetramer interface [polypeptide binding]; other site 1138382009330 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1138382009331 active site 1138382009332 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1138382009333 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1138382009334 active site 1138382009335 Hemerythrin-like domain; Region: Hr-like; cd12108 1138382009336 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1138382009337 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382009338 iron-sulfur cluster [ion binding]; other site 1138382009339 [2Fe-2S] cluster binding site [ion binding]; other site 1138382009340 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 1138382009341 alpha subunit interaction site [polypeptide binding]; other site 1138382009342 beta subunit interaction site [polypeptide binding]; other site 1138382009343 iron-sulfur cluster [ion binding]; other site 1138382009344 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1138382009345 beta subunit interface [polypeptide binding]; other site 1138382009346 alpha subunit interface [polypeptide binding]; other site 1138382009347 active site 1138382009348 substrate binding site [chemical binding]; other site 1138382009349 Fe binding site [ion binding]; other site 1138382009350 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1138382009351 inter-subunit interface; other site 1138382009352 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1138382009353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382009354 NAD(P) binding site [chemical binding]; other site 1138382009355 active site 1138382009356 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1138382009357 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138382009358 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382009359 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138382009360 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138382009361 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138382009362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382009363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382009364 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382009365 anti sigma factor interaction site; other site 1138382009366 regulatory phosphorylation site [posttranslational modification]; other site 1138382009367 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1138382009368 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1138382009369 Predicted permeases [General function prediction only]; Region: COG0730 1138382009370 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1138382009371 putative heme binding pocket [chemical binding]; other site 1138382009372 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382009373 classical (c) SDRs; Region: SDR_c; cd05233 1138382009374 NAD(P) binding site [chemical binding]; other site 1138382009375 active site 1138382009376 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138382009377 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382009378 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382009379 acyl-activating enzyme (AAE) consensus motif; other site 1138382009380 putative AMP binding site [chemical binding]; other site 1138382009381 putative active site [active] 1138382009382 putative CoA binding site [chemical binding]; other site 1138382009383 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138382009384 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138382009385 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382009386 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382009387 substrate binding site [chemical binding]; other site 1138382009388 oxyanion hole (OAH) forming residues; other site 1138382009389 trimer interface [polypeptide binding]; other site 1138382009390 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382009391 hydrophobic ligand binding site; other site 1138382009392 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138382009393 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382009394 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382009395 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1138382009396 classical (c) SDRs; Region: SDR_c; cd05233 1138382009397 NAD(P) binding site [chemical binding]; other site 1138382009398 active site 1138382009399 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382009400 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138382009401 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382009402 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1138382009403 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382009404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382009405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382009406 short chain dehydrogenase; Provisional; Region: PRK12827 1138382009407 classical (c) SDRs; Region: SDR_c; cd05233 1138382009408 NAD(P) binding site [chemical binding]; other site 1138382009409 active site 1138382009410 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382009411 classical (c) SDRs; Region: SDR_c; cd05233 1138382009412 NAD(P) binding site [chemical binding]; other site 1138382009413 active site 1138382009414 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138382009415 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138382009416 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382009417 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382009418 NAD(P) binding site [chemical binding]; other site 1138382009419 catalytic residues [active] 1138382009420 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138382009421 Cation efflux family; Region: Cation_efflux; cl00316 1138382009422 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382009423 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382009424 Clp amino terminal domain; Region: Clp_N; pfam02861 1138382009425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382009426 Coenzyme A binding pocket [chemical binding]; other site 1138382009427 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1138382009428 hypothetical protein; Provisional; Region: PRK14059 1138382009429 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1138382009430 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382009431 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138382009432 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138382009433 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1138382009434 SelR domain; Region: SelR; pfam01641 1138382009435 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382009436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382009437 S-adenosylmethionine binding site [chemical binding]; other site 1138382009438 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1138382009439 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1138382009440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382009441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382009442 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1138382009443 substrate binding site [chemical binding]; other site 1138382009444 active site 1138382009445 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382009446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382009447 substrate binding site [chemical binding]; other site 1138382009448 oxyanion hole (OAH) forming residues; other site 1138382009449 trimer interface [polypeptide binding]; other site 1138382009450 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1138382009451 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1138382009452 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1138382009453 catalytic site [active] 1138382009454 putative active site [active] 1138382009455 putative substrate binding site [chemical binding]; other site 1138382009456 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1138382009457 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1138382009458 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1138382009459 TPP-binding site; other site 1138382009460 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138382009461 PYR/PP interface [polypeptide binding]; other site 1138382009462 dimer interface [polypeptide binding]; other site 1138382009463 TPP binding site [chemical binding]; other site 1138382009464 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138382009465 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138382009466 FOG: CBS domain [General function prediction only]; Region: COG0517 1138382009467 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1138382009468 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1138382009469 transmembrane helices; other site 1138382009470 TRAM domain; Region: TRAM; pfam01938 1138382009471 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1138382009472 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138382009473 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138382009474 TrkA-N domain; Region: TrkA_N; pfam02254 1138382009475 TrkA-C domain; Region: TrkA_C; pfam02080 1138382009476 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138382009477 TrkA-N domain; Region: TrkA_N; pfam02254 1138382009478 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1138382009479 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138382009480 generic binding surface II; other site 1138382009481 ssDNA binding site; other site 1138382009482 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1138382009483 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138382009484 trimer interface [polypeptide binding]; other site 1138382009485 active site 1138382009486 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1138382009487 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1138382009488 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138382009489 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138382009490 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1138382009491 active site 1138382009492 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138382009493 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382009494 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138382009495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382009496 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138382009497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382009498 DNA binding residues [nucleotide binding] 1138382009499 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1138382009500 homotrimer interaction site [polypeptide binding]; other site 1138382009501 putative active site [active] 1138382009502 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1138382009503 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1138382009504 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1138382009505 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138382009506 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1138382009507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382009508 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138382009509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382009510 DNA binding residues [nucleotide binding] 1138382009511 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138382009512 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1138382009513 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138382009514 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1138382009515 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1138382009516 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1138382009517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382009518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382009519 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138382009520 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138382009521 PAC2 family; Region: PAC2; pfam09754 1138382009522 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382009523 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138382009524 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1138382009525 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138382009526 heme-binding site [chemical binding]; other site 1138382009527 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 1138382009528 ATP cone domain; Region: ATP-cone; pfam03477 1138382009529 LexA repressor; Validated; Region: PRK00215 1138382009530 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1138382009531 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1138382009532 Catalytic site [active] 1138382009533 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138382009534 LGFP repeat; Region: LGFP; pfam08310 1138382009535 LGFP repeat; Region: LGFP; pfam08310 1138382009536 LGFP repeat; Region: LGFP; pfam08310 1138382009537 LGFP repeat; Region: LGFP; pfam08310 1138382009538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382009539 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382009540 active site 1138382009541 GTPases [General function prediction only]; Region: HflX; COG2262 1138382009542 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1138382009543 HflX GTPase family; Region: HflX; cd01878 1138382009544 G1 box; other site 1138382009545 GTP/Mg2+ binding site [chemical binding]; other site 1138382009546 Switch I region; other site 1138382009547 G2 box; other site 1138382009548 G3 box; other site 1138382009549 Switch II region; other site 1138382009550 G4 box; other site 1138382009551 G5 box; other site 1138382009552 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1138382009553 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138382009554 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138382009555 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1138382009556 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1138382009557 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1138382009558 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138382009559 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138382009560 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1138382009561 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1138382009562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382009563 FeS/SAM binding site; other site 1138382009564 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1138382009565 recombinase A; Provisional; Region: recA; PRK09354 1138382009566 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1138382009567 hexamer interface [polypeptide binding]; other site 1138382009568 Walker A motif; other site 1138382009569 ATP binding site [chemical binding]; other site 1138382009570 Walker B motif; other site 1138382009571 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1138382009572 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1138382009573 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138382009574 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138382009575 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1138382009576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138382009577 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 1138382009578 PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674 1138382009579 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138382009580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382009581 non-specific DNA binding site [nucleotide binding]; other site 1138382009582 salt bridge; other site 1138382009583 sequence-specific DNA binding site [nucleotide binding]; other site 1138382009584 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138382009585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382009586 Coenzyme A binding pocket [chemical binding]; other site 1138382009587 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1138382009588 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1138382009589 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382009590 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1138382009591 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138382009592 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1138382009593 classical (c) SDRs; Region: SDR_c; cd05233 1138382009594 NAD(P) binding site [chemical binding]; other site 1138382009595 active site 1138382009596 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382009597 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382009598 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1138382009599 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382009600 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1138382009601 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138382009602 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1138382009603 dimer interface [polypeptide binding]; other site 1138382009604 active site 1138382009605 catalytic residue [active] 1138382009606 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1138382009607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1138382009608 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1138382009609 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1138382009610 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1138382009611 folate binding site [chemical binding]; other site 1138382009612 NADP+ binding site [chemical binding]; other site 1138382009613 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1138382009614 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1138382009615 dimerization interface [polypeptide binding]; other site 1138382009616 active site 1138382009617 Dienelactone hydrolase family; Region: DLH; pfam01738 1138382009618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382009619 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382009620 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382009621 active site 1138382009622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382009623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382009624 active site 1138382009625 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138382009626 classical (c) SDRs; Region: SDR_c; cd05233 1138382009627 NAD(P) binding site [chemical binding]; other site 1138382009628 active site 1138382009629 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1138382009630 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382009631 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382009632 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138382009633 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1138382009634 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138382009635 carboxyltransferase (CT) interaction site; other site 1138382009636 biotinylation site [posttranslational modification]; other site 1138382009637 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138382009638 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382009639 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382009640 acyl-activating enzyme (AAE) consensus motif; other site 1138382009641 AMP binding site [chemical binding]; other site 1138382009642 active site 1138382009643 CoA binding site [chemical binding]; other site 1138382009644 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138382009645 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382009646 CoenzymeA binding site [chemical binding]; other site 1138382009647 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138382009648 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138382009649 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1138382009650 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138382009651 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1138382009652 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382009653 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138382009654 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382009655 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382009656 iron-sulfur cluster [ion binding]; other site 1138382009657 [2Fe-2S] cluster binding site [ion binding]; other site 1138382009658 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1138382009659 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138382009660 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1138382009661 FMN-binding pocket [chemical binding]; other site 1138382009662 flavin binding motif; other site 1138382009663 phosphate binding motif [ion binding]; other site 1138382009664 beta-alpha-beta structure motif; other site 1138382009665 NAD binding pocket [chemical binding]; other site 1138382009666 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382009667 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138382009668 catalytic loop [active] 1138382009669 iron binding site [ion binding]; other site 1138382009670 short chain dehydrogenase; Validated; Region: PRK05855 1138382009671 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382009672 classical (c) SDRs; Region: SDR_c; cd05233 1138382009673 NAD(P) binding site [chemical binding]; other site 1138382009674 active site 1138382009675 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138382009676 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138382009677 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382009678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382009679 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382009680 hydrophobic ligand binding site; other site 1138382009681 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1138382009682 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1138382009683 hexamer interface [polypeptide binding]; other site 1138382009684 ligand binding site [chemical binding]; other site 1138382009685 putative active site [active] 1138382009686 NAD(P) binding site [chemical binding]; other site 1138382009687 Nitronate monooxygenase; Region: NMO; pfam03060 1138382009688 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382009689 FMN binding site [chemical binding]; other site 1138382009690 substrate binding site [chemical binding]; other site 1138382009691 putative catalytic residue [active] 1138382009692 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1138382009693 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1138382009694 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1138382009695 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1138382009696 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1138382009697 oligomer interface [polypeptide binding]; other site 1138382009698 RNA binding site [nucleotide binding]; other site 1138382009699 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1138382009700 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1138382009701 RNase E interface [polypeptide binding]; other site 1138382009702 trimer interface [polypeptide binding]; other site 1138382009703 active site 1138382009704 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1138382009705 putative nucleic acid binding region [nucleotide binding]; other site 1138382009706 G-X-X-G motif; other site 1138382009707 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1138382009708 RNA binding site [nucleotide binding]; other site 1138382009709 domain interface; other site 1138382009710 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1138382009711 16S/18S rRNA binding site [nucleotide binding]; other site 1138382009712 S13e-L30e interaction site [polypeptide binding]; other site 1138382009713 25S rRNA binding site [nucleotide binding]; other site 1138382009714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382009715 dimerization interface [polypeptide binding]; other site 1138382009716 putative DNA binding site [nucleotide binding]; other site 1138382009717 putative Zn2+ binding site [ion binding]; other site 1138382009718 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1138382009719 putative hydrophobic ligand binding site [chemical binding]; other site 1138382009720 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1138382009721 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1138382009722 active site 1138382009723 Riboflavin kinase; Region: Flavokinase; pfam01687 1138382009724 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138382009725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382009726 putative DNA binding site [nucleotide binding]; other site 1138382009727 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138382009728 FeoA domain; Region: FeoA; pfam04023 1138382009729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382009730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382009731 active site 1138382009732 lipid-transfer protein; Provisional; Region: PRK08256 1138382009733 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382009734 active site 1138382009735 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1138382009736 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1138382009737 RNA binding site [nucleotide binding]; other site 1138382009738 active site 1138382009739 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1138382009740 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1138382009741 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1138382009742 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138382009743 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138382009744 active site 1138382009745 metal binding site [ion binding]; metal-binding site 1138382009746 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138382009747 active site 1138382009748 metal binding site [ion binding]; metal-binding site 1138382009749 Predicted acyl esterases [General function prediction only]; Region: COG2936 1138382009750 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138382009751 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1138382009752 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1138382009753 enoyl-CoA hydratase; Provisional; Region: PRK06190 1138382009754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382009755 substrate binding site [chemical binding]; other site 1138382009756 oxyanion hole (OAH) forming residues; other site 1138382009757 trimer interface [polypeptide binding]; other site 1138382009758 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1138382009759 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1138382009760 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1138382009761 DHH family; Region: DHH; pfam01368 1138382009762 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1138382009763 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1138382009764 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1138382009765 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1138382009766 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1138382009767 G1 box; other site 1138382009768 putative GEF interaction site [polypeptide binding]; other site 1138382009769 GTP/Mg2+ binding site [chemical binding]; other site 1138382009770 Switch I region; other site 1138382009771 G2 box; other site 1138382009772 G3 box; other site 1138382009773 Switch II region; other site 1138382009774 G4 box; other site 1138382009775 G5 box; other site 1138382009776 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1138382009777 Translation-initiation factor 2; Region: IF-2; pfam11987 1138382009778 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1138382009779 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1138382009780 putative RNA binding cleft [nucleotide binding]; other site 1138382009781 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1138382009782 NusA N-terminal domain; Region: NusA_N; pfam08529 1138382009783 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1138382009784 RNA binding site [nucleotide binding]; other site 1138382009785 homodimer interface [polypeptide binding]; other site 1138382009786 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138382009787 G-X-X-G motif; other site 1138382009788 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138382009789 G-X-X-G motif; other site 1138382009790 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1138382009791 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1138382009792 putative oligomer interface [polypeptide binding]; other site 1138382009793 putative RNA binding site [nucleotide binding]; other site 1138382009794 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1138382009795 dinuclear metal binding motif [ion binding]; other site 1138382009796 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1138382009797 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138382009798 motif 1; other site 1138382009799 dimer interface [polypeptide binding]; other site 1138382009800 active site 1138382009801 motif 2; other site 1138382009802 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1138382009803 putative deacylase active site [active] 1138382009804 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138382009805 active site 1138382009806 motif 3; other site 1138382009807 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1138382009808 anticodon binding site; other site 1138382009809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382009810 putative substrate translocation pore; other site 1138382009811 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1138382009812 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1138382009813 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1138382009814 active site 1138382009815 SAM binding site [chemical binding]; other site 1138382009816 homodimer interface [polypeptide binding]; other site 1138382009817 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1138382009818 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1138382009819 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1138382009820 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1138382009821 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1138382009822 Walker A motif; other site 1138382009823 homodimer interface [polypeptide binding]; other site 1138382009824 ATP binding site [chemical binding]; other site 1138382009825 hydroxycobalamin binding site [chemical binding]; other site 1138382009826 Walker B motif; other site 1138382009827 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1138382009828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1138382009829 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1138382009830 metal ion-dependent adhesion site (MIDAS); other site 1138382009831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138382009832 Coenzyme A binding pocket [chemical binding]; other site 1138382009833 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1138382009834 malate:quinone oxidoreductase; Validated; Region: PRK05257 1138382009835 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138382009836 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382009837 mycothione reductase; Reviewed; Region: PRK07846 1138382009838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382009839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382009840 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138382009841 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1138382009842 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 1138382009843 nickel binding site [ion binding]; other site 1138382009844 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1138382009845 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1138382009846 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1138382009847 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382009848 PPE family; Region: PPE; pfam00823 1138382009849 short chain dehydrogenase; Provisional; Region: PRK06057 1138382009850 classical (c) SDRs; Region: SDR_c; cd05233 1138382009851 NAD(P) binding site [chemical binding]; other site 1138382009852 active site 1138382009853 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382009854 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382009855 NAD(P) binding site [chemical binding]; other site 1138382009856 catalytic residues [active] 1138382009857 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1138382009858 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1138382009859 catalytic triad [active] 1138382009860 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138382009861 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138382009862 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382009863 cobyric acid synthase; Provisional; Region: PRK00784 1138382009864 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1138382009865 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138382009866 catalytic triad [active] 1138382009867 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138382009868 active site 1138382009869 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138382009870 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1138382009871 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138382009872 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138382009873 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1138382009874 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1138382009875 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138382009876 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1138382009877 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138382009878 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1138382009879 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1138382009880 active site 1138382009881 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1138382009882 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1138382009883 putative substrate binding region [chemical binding]; other site 1138382009884 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1138382009885 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1138382009886 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1138382009887 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1138382009888 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138382009889 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1138382009890 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138382009891 catalytic residues [active] 1138382009892 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1138382009893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382009894 FeS/SAM binding site; other site 1138382009895 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1138382009896 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1138382009897 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1138382009898 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1138382009899 hinge region; other site 1138382009900 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1138382009901 putative nucleotide binding site [chemical binding]; other site 1138382009902 uridine monophosphate binding site [chemical binding]; other site 1138382009903 homohexameric interface [polypeptide binding]; other site 1138382009904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382009905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382009906 DNA binding site [nucleotide binding] 1138382009907 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382009908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138382009909 putative acyl-acceptor binding pocket; other site 1138382009910 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1138382009911 short chain dehydrogenase; Provisional; Region: PRK06701 1138382009912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382009913 NAD(P) binding site [chemical binding]; other site 1138382009914 active site 1138382009915 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1138382009916 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138382009917 Moco binding site; other site 1138382009918 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138382009919 metal coordination site [ion binding]; other site 1138382009920 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1138382009921 ChaB; Region: ChaB; pfam06150 1138382009922 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1138382009923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382009924 MarR family; Region: MarR; pfam01047 1138382009925 amidase; Provisional; Region: PRK07869 1138382009926 Amidase; Region: Amidase; pfam01425 1138382009927 elongation factor Ts; Provisional; Region: tsf; PRK09377 1138382009928 UBA/TS-N domain; Region: UBA; pfam00627 1138382009929 Elongation factor TS; Region: EF_TS; pfam00889 1138382009930 Elongation factor TS; Region: EF_TS; pfam00889 1138382009931 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1138382009932 rRNA interaction site [nucleotide binding]; other site 1138382009933 S8 interaction site; other site 1138382009934 putative laminin-1 binding site; other site 1138382009935 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138382009936 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138382009937 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1138382009938 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138382009939 active site 1138382009940 DNA binding site [nucleotide binding] 1138382009941 Int/Topo IB signature motif; other site 1138382009942 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1138382009943 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1138382009944 putative active site [active] 1138382009945 putative substrate binding site [chemical binding]; other site 1138382009946 putative FMN binding site [chemical binding]; other site 1138382009947 putative catalytic residues [active] 1138382009948 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138382009949 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138382009950 FAD binding pocket [chemical binding]; other site 1138382009951 FAD binding motif [chemical binding]; other site 1138382009952 phosphate binding motif [ion binding]; other site 1138382009953 NAD binding pocket [chemical binding]; other site 1138382009954 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1138382009955 DNA protecting protein DprA; Region: dprA; TIGR00732 1138382009956 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1138382009957 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1138382009958 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138382009959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382009960 Walker A motif; other site 1138382009961 ATP binding site [chemical binding]; other site 1138382009962 Walker B motif; other site 1138382009963 arginine finger; other site 1138382009964 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1138382009965 hypothetical protein; Reviewed; Region: PRK12497 1138382009966 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1138382009967 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1138382009968 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1138382009969 putative molybdopterin cofactor binding site [chemical binding]; other site 1138382009970 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1138382009971 putative molybdopterin cofactor binding site; other site 1138382009972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382009973 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138382009974 NAD(P) binding site [chemical binding]; other site 1138382009975 active site 1138382009976 ANTAR domain; Region: ANTAR; pfam03861 1138382009977 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1138382009978 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1138382009979 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138382009980 active site 1138382009981 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1138382009982 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138382009983 Catalytic site [active] 1138382009984 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138382009985 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1138382009986 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1138382009987 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1138382009988 RimM N-terminal domain; Region: RimM; pfam01782 1138382009989 PRC-barrel domain; Region: PRC; pfam05239 1138382009990 hypothetical protein; Provisional; Region: PRK02821 1138382009991 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1138382009992 G-X-X-G motif; other site 1138382009993 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1138382009994 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138382009995 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138382009996 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138382009997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382009998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382009999 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138382010000 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382010001 active site 1138382010002 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382010003 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138382010004 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382010005 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382010006 active site 1138382010007 signal recognition particle protein; Provisional; Region: PRK10867 1138382010008 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1138382010009 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1138382010010 P loop; other site 1138382010011 GTP binding site [chemical binding]; other site 1138382010012 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1138382010013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382010014 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138382010015 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138382010016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382010017 ATP binding site [chemical binding]; other site 1138382010018 putative Mg++ binding site [ion binding]; other site 1138382010019 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382010020 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382010021 active site 1138382010022 potential frameshift: common BLAST hit: gi|120405443|ref|YP_955272.1| transposase, IS111A/IS1328/IS1533 1138382010023 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382010024 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382010025 PII uridylyl-transferase; Provisional; Region: PRK03381 1138382010026 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138382010027 metal binding triad; other site 1138382010028 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138382010029 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1138382010030 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1138382010031 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1138382010032 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1138382010033 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1138382010034 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1138382010035 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1138382010036 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1138382010037 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138382010038 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138382010039 AAA domain; Region: AAA_23; pfam13476 1138382010040 Walker A/P-loop; other site 1138382010041 ATP binding site [chemical binding]; other site 1138382010042 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1138382010043 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1138382010044 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138382010045 ABC transporter signature motif; other site 1138382010046 Walker B; other site 1138382010047 D-loop; other site 1138382010048 H-loop/switch region; other site 1138382010049 acylphosphatase; Provisional; Region: PRK14422 1138382010050 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1138382010051 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1138382010052 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1138382010053 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1138382010054 DNA binding site [nucleotide binding] 1138382010055 catalytic residue [active] 1138382010056 H2TH interface [polypeptide binding]; other site 1138382010057 putative catalytic residues [active] 1138382010058 turnover-facilitating residue; other site 1138382010059 intercalation triad [nucleotide binding]; other site 1138382010060 8OG recognition residue [nucleotide binding]; other site 1138382010061 putative reading head residues; other site 1138382010062 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138382010063 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138382010064 ribonuclease III; Reviewed; Region: rnc; PRK00102 1138382010065 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1138382010066 dimerization interface [polypeptide binding]; other site 1138382010067 active site 1138382010068 metal binding site [ion binding]; metal-binding site 1138382010069 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1138382010070 dsRNA binding site [nucleotide binding]; other site 1138382010071 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1138382010072 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138382010073 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1138382010074 Predicted permease; Region: DUF318; pfam03773 1138382010075 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1138382010076 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138382010077 PYR/PP interface [polypeptide binding]; other site 1138382010078 dimer interface [polypeptide binding]; other site 1138382010079 TPP binding site [chemical binding]; other site 1138382010080 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382010081 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1138382010082 TPP-binding site [chemical binding]; other site 1138382010083 dimer interface [polypeptide binding]; other site 1138382010084 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1138382010085 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1138382010086 active site 1138382010087 (T/H)XGH motif; other site 1138382010088 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1138382010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382010090 S-adenosylmethionine binding site [chemical binding]; other site 1138382010091 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1138382010092 putative active site [active] 1138382010093 redox center [active] 1138382010094 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1138382010095 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1138382010096 catalytic residues [active] 1138382010097 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382010098 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382010099 substrate binding pocket [chemical binding]; other site 1138382010100 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382010101 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382010102 active site 1138382010103 catalytic tetrad [active] 1138382010104 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1138382010105 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1138382010106 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138382010107 ssDNA binding site; other site 1138382010108 generic binding surface II; other site 1138382010109 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382010110 ATP binding site [chemical binding]; other site 1138382010111 putative Mg++ binding site [ion binding]; other site 1138382010112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382010113 nucleotide binding region [chemical binding]; other site 1138382010114 ATP-binding site [chemical binding]; other site 1138382010115 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1138382010116 DAK2 domain; Region: Dak2; cl03685 1138382010117 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138382010118 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138382010119 catalytic residue [active] 1138382010120 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138382010121 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382010122 classical (c) SDRs; Region: SDR_c; cd05233 1138382010123 NAD(P) binding site [chemical binding]; other site 1138382010124 active site 1138382010125 short chain dehydrogenase; Provisional; Region: PRK06197 1138382010126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382010127 NAD(P) binding site [chemical binding]; other site 1138382010128 active site 1138382010129 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138382010130 short chain dehydrogenase; Provisional; Region: PRK06180 1138382010131 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138382010132 NADP binding site [chemical binding]; other site 1138382010133 active site 1138382010134 steroid binding site; other site 1138382010135 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138382010136 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138382010137 putative NAD(P) binding site [chemical binding]; other site 1138382010138 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1138382010139 ligand binding site [chemical binding]; other site 1138382010140 active site 1138382010141 UGI interface [polypeptide binding]; other site 1138382010142 catalytic site [active] 1138382010143 thiamine monophosphate kinase; Provisional; Region: PRK05731 1138382010144 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1138382010145 ATP binding site [chemical binding]; other site 1138382010146 dimerization interface [polypeptide binding]; other site 1138382010147 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1138382010148 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1138382010149 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1138382010150 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1138382010151 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1138382010152 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138382010153 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138382010154 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1138382010155 polyphosphate kinase; Provisional; Region: PRK05443 1138382010156 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1138382010157 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1138382010158 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1138382010159 putative domain interface [polypeptide binding]; other site 1138382010160 putative active site [active] 1138382010161 catalytic site [active] 1138382010162 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1138382010163 putative domain interface [polypeptide binding]; other site 1138382010164 putative active site [active] 1138382010165 catalytic site [active] 1138382010166 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138382010167 active site 1138382010168 Ap6A binding site [chemical binding]; other site 1138382010169 nudix motif; other site 1138382010170 metal binding site [ion binding]; metal-binding site 1138382010171 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382010172 catalytic core [active] 1138382010173 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1138382010174 IHF dimer interface [polypeptide binding]; other site 1138382010175 IHF - DNA interface [nucleotide binding]; other site 1138382010176 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1138382010177 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1138382010178 substrate binding site [chemical binding]; other site 1138382010179 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1138382010180 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1138382010181 substrate binding site [chemical binding]; other site 1138382010182 ligand binding site [chemical binding]; other site 1138382010183 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138382010184 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382010185 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138382010186 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382010187 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1138382010188 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138382010189 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1138382010190 active site 1138382010191 KMSKS motif; other site 1138382010192 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1138382010193 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138382010194 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138382010195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382010196 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138382010197 putative substrate translocation pore; other site 1138382010198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382010199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138382010200 putative substrate translocation pore; other site 1138382010201 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1138382010202 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1138382010203 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1138382010204 ligand binding site [chemical binding]; other site 1138382010205 NAD binding site [chemical binding]; other site 1138382010206 dimerization interface [polypeptide binding]; other site 1138382010207 catalytic site [active] 1138382010208 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1138382010209 putative L-serine binding site [chemical binding]; other site 1138382010210 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138382010211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382010212 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1138382010213 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138382010214 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1138382010215 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1138382010216 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1138382010217 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1138382010218 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1138382010219 putative valine binding site [chemical binding]; other site 1138382010220 dimer interface [polypeptide binding]; other site 1138382010221 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1138382010222 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1138382010223 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138382010224 PYR/PP interface [polypeptide binding]; other site 1138382010225 dimer interface [polypeptide binding]; other site 1138382010226 TPP binding site [chemical binding]; other site 1138382010227 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382010228 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1138382010229 TPP-binding site [chemical binding]; other site 1138382010230 dimer interface [polypeptide binding]; other site 1138382010231 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138382010232 Predicted membrane protein [Function unknown]; Region: COG2259 1138382010233 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1138382010234 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1138382010235 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1138382010236 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1138382010237 GatB domain; Region: GatB_Yqey; smart00845 1138382010238 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138382010239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138382010240 P-loop; other site 1138382010241 Magnesium ion binding site [ion binding]; other site 1138382010242 6-phosphofructokinase; Provisional; Region: PRK03202 1138382010243 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1138382010244 active site 1138382010245 ADP/pyrophosphate binding site [chemical binding]; other site 1138382010246 dimerization interface [polypeptide binding]; other site 1138382010247 allosteric effector site; other site 1138382010248 fructose-1,6-bisphosphate binding site; other site 1138382010249 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138382010250 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1138382010251 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1138382010252 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1138382010253 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382010254 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382010255 active site 1138382010256 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138382010257 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382010258 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138382010259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382010261 cystathionine gamma-lyase; Validated; Region: PRK07582 1138382010262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382010263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382010264 catalytic residue [active] 1138382010265 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1138382010266 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1138382010267 nucleotide binding pocket [chemical binding]; other site 1138382010268 K-X-D-G motif; other site 1138382010269 catalytic site [active] 1138382010270 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1138382010271 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1138382010272 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1138382010273 Dimer interface [polypeptide binding]; other site 1138382010274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138382010275 putative DNA binding site [nucleotide binding]; other site 1138382010276 putative Zn2+ binding site [ion binding]; other site 1138382010277 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1138382010278 putative hydrophobic ligand binding site [chemical binding]; other site 1138382010279 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1138382010280 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382010281 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1138382010282 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1138382010283 Ligand Binding Site [chemical binding]; other site 1138382010284 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1138382010285 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1138382010286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138382010287 catalytic residue [active] 1138382010288 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382010289 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138382010290 putative acyl-acceptor binding pocket; other site 1138382010291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1138382010292 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1138382010293 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1138382010294 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1138382010295 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1138382010296 Ligand binding site [chemical binding]; other site 1138382010297 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1138382010298 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138382010299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382010300 S-adenosylmethionine binding site [chemical binding]; other site 1138382010301 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1138382010302 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1138382010303 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1138382010304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382010305 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382010306 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1138382010307 putative hydrophobic ligand binding site [chemical binding]; other site 1138382010308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382010309 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1138382010310 NAD(P) binding site [chemical binding]; other site 1138382010311 active site 1138382010312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382010313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382010314 NAD(P) binding site [chemical binding]; other site 1138382010315 active site 1138382010316 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382010317 anti sigma factor interaction site; other site 1138382010318 regulatory phosphorylation site [posttranslational modification]; other site 1138382010319 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138382010320 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138382010321 substrate binding pocket [chemical binding]; other site 1138382010322 chain length determination region; other site 1138382010323 substrate-Mg2+ binding site; other site 1138382010324 catalytic residues [active] 1138382010325 aspartate-rich region 1; other site 1138382010326 active site lid residues [active] 1138382010327 aspartate-rich region 2; other site 1138382010328 phytoene desaturase; Region: crtI_fam; TIGR02734 1138382010329 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1138382010330 active site lid residues [active] 1138382010331 substrate binding pocket [chemical binding]; other site 1138382010332 catalytic residues [active] 1138382010333 substrate-Mg2+ binding site; other site 1138382010334 aspartate-rich region 1; other site 1138382010335 aspartate-rich region 2; other site 1138382010336 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1138382010337 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1138382010338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382010339 S-adenosylmethionine binding site [chemical binding]; other site 1138382010340 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1138382010341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382010342 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138382010343 [2Fe-2S] cluster binding site [ion binding]; other site 1138382010344 iron-sulfur cluster [ion binding]; other site 1138382010345 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1138382010346 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1138382010347 MarR family; Region: MarR_2; pfam12802 1138382010348 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138382010349 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1138382010350 active site 1138382010351 TDP-binding site; other site 1138382010352 acceptor substrate-binding pocket; other site 1138382010353 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1138382010354 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1138382010355 homotetramer interface [polypeptide binding]; other site 1138382010356 FMN binding site [chemical binding]; other site 1138382010357 homodimer contacts [polypeptide binding]; other site 1138382010358 putative active site [active] 1138382010359 putative substrate binding site [chemical binding]; other site 1138382010360 MMPL family; Region: MMPL; pfam03176 1138382010361 TspO/MBR family; Region: TspO_MBR; pfam03073 1138382010362 DNA photolyase; Region: DNA_photolyase; pfam00875 1138382010363 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1138382010364 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138382010365 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138382010366 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1138382010367 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1138382010368 trimer interface [polypeptide binding]; other site 1138382010369 active site 1138382010370 substrate binding site [chemical binding]; other site 1138382010371 CoA binding site [chemical binding]; other site 1138382010372 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1138382010373 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138382010374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382010375 S-adenosylmethionine binding site [chemical binding]; other site 1138382010376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382010377 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382010378 substrate binding site [chemical binding]; other site 1138382010379 oxyanion hole (OAH) forming residues; other site 1138382010380 trimer interface [polypeptide binding]; other site 1138382010381 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1138382010382 nudix motif; other site 1138382010383 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1138382010384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382010385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382010386 Walker A/P-loop; other site 1138382010387 Walker A/P-loop; other site 1138382010388 ATP binding site [chemical binding]; other site 1138382010389 ATP binding site [chemical binding]; other site 1138382010390 Q-loop/lid; other site 1138382010391 ABC transporter signature motif; other site 1138382010392 Walker B; other site 1138382010393 D-loop; other site 1138382010394 H-loop/switch region; other site 1138382010395 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1138382010396 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1138382010397 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1138382010398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382010399 motif II; other site 1138382010400 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1138382010401 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1138382010402 D-pathway; other site 1138382010403 Putative ubiquinol binding site [chemical binding]; other site 1138382010404 Low-spin heme (heme b) binding site [chemical binding]; other site 1138382010405 Putative water exit pathway; other site 1138382010406 Binuclear center (heme o3/CuB) [ion binding]; other site 1138382010407 K-pathway; other site 1138382010408 Putative proton exit pathway; other site 1138382010409 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1138382010410 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1138382010411 siderophore binding site; other site 1138382010412 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1138382010413 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1138382010414 putative NAD(P) binding site [chemical binding]; other site 1138382010415 putative substrate binding site [chemical binding]; other site 1138382010416 catalytic Zn binding site [ion binding]; other site 1138382010417 structural Zn binding site [ion binding]; other site 1138382010418 dimer interface [polypeptide binding]; other site 1138382010419 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138382010420 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138382010421 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138382010422 dimer interface [polypeptide binding]; other site 1138382010423 putative radical transfer pathway; other site 1138382010424 diiron center [ion binding]; other site 1138382010425 tyrosyl radical; other site 1138382010426 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1138382010427 putative hydrophobic ligand binding site [chemical binding]; other site 1138382010428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382010430 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138382010431 Ligand Binding Site [chemical binding]; other site 1138382010432 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382010433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382010434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382010436 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138382010437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382010438 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1138382010439 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1138382010440 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1138382010441 active site 1138382010442 dimer interface [polypeptide binding]; other site 1138382010443 catalytic residues [active] 1138382010444 effector binding site; other site 1138382010445 R2 peptide binding site; other site 1138382010446 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1138382010447 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138382010448 catalytic residues [active] 1138382010449 Predicted flavoprotein [General function prediction only]; Region: COG0431 1138382010450 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138382010451 short chain dehydrogenase; Provisional; Region: PRK07832 1138382010452 classical (c) SDRs; Region: SDR_c; cd05233 1138382010453 NAD(P) binding site [chemical binding]; other site 1138382010454 active site 1138382010455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382010457 Cytochrome P450; Region: p450; cl12078 1138382010458 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382010459 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1138382010460 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1138382010461 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138382010462 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138382010463 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138382010464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382010465 DNA-binding site [nucleotide binding]; DNA binding site 1138382010466 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138382010467 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138382010468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1138382010469 DNA-binding site [nucleotide binding]; DNA binding site 1138382010470 FCD domain; Region: FCD; pfam07729 1138382010471 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382010472 active site 1138382010473 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382010474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382010475 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382010476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382010477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382010478 active site 1138382010479 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1138382010480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382010481 NAD(P) binding site [chemical binding]; other site 1138382010482 active site 1138382010483 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1138382010484 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1138382010485 active site 1138382010486 DNA binding site [nucleotide binding] 1138382010487 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1138382010488 DNA binding site [nucleotide binding] 1138382010489 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1138382010490 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1138382010491 nucleotide binding site [chemical binding]; other site 1138382010492 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1138382010493 SBD interface [polypeptide binding]; other site 1138382010494 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138382010495 FMN binding site [chemical binding]; other site 1138382010496 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138382010497 dimer interface [polypeptide binding]; other site 1138382010498 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382010499 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138382010500 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382010501 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1138382010502 dimer interface [polypeptide binding]; other site 1138382010503 active site 1138382010504 enoyl-CoA hydratase; Provisional; Region: PRK05864 1138382010505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382010506 substrate binding site [chemical binding]; other site 1138382010507 oxyanion hole (OAH) forming residues; other site 1138382010508 trimer interface [polypeptide binding]; other site 1138382010509 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382010510 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382010511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382010512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382010513 active site 1138382010514 MspA; Region: MspA; pfam09203 1138382010515 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382010516 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382010517 putative active site [active] 1138382010518 putative substrate binding site [chemical binding]; other site 1138382010519 ATP binding site [chemical binding]; other site 1138382010520 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1138382010521 classical (c) SDRs; Region: SDR_c; cd05233 1138382010522 NAD(P) binding site [chemical binding]; other site 1138382010523 active site 1138382010524 Predicted membrane protein [Function unknown]; Region: COG2259 1138382010525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382010526 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1138382010527 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382010528 Transport protein; Region: actII; TIGR00833 1138382010529 potential frameshift: common BLAST hit: gi|375142472|ref|YP_005003121.1| oxidoreductase, SDR family 1138382010530 classical (c) SDRs; Region: SDR_c; cd05233 1138382010531 classical (c) SDRs; Region: SDR_c; cd05233 1138382010532 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382010533 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138382010534 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138382010535 substrate binding pocket [chemical binding]; other site 1138382010536 active site 1138382010537 iron coordination sites [ion binding]; other site 1138382010538 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382010539 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382010540 [2Fe-2S] cluster binding site [ion binding]; other site 1138382010541 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138382010542 alpha subunit interface [polypeptide binding]; other site 1138382010543 active site 1138382010544 substrate binding site [chemical binding]; other site 1138382010545 Fe binding site [ion binding]; other site 1138382010546 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382010547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382010548 NAD(P) binding site [chemical binding]; other site 1138382010549 active site 1138382010550 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138382010551 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138382010552 FAD binding pocket [chemical binding]; other site 1138382010553 FAD binding motif [chemical binding]; other site 1138382010554 phosphate binding motif [ion binding]; other site 1138382010555 beta-alpha-beta structure motif; other site 1138382010556 NAD(p) ribose binding residues [chemical binding]; other site 1138382010557 NAD binding pocket [chemical binding]; other site 1138382010558 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138382010559 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382010560 catalytic loop [active] 1138382010561 iron binding site [ion binding]; other site 1138382010562 MarR family; Region: MarR_2; pfam12802 1138382010563 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382010564 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138382010565 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138382010566 active site 1138382010567 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382010568 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382010569 [2Fe-2S] cluster binding site [ion binding]; other site 1138382010570 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138382010571 alpha subunit interface [polypeptide binding]; other site 1138382010572 active site 1138382010573 substrate binding site [chemical binding]; other site 1138382010574 Fe binding site [ion binding]; other site 1138382010575 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382010576 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138382010577 NAD binding site [chemical binding]; other site 1138382010578 catalytic residues [active] 1138382010579 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1138382010580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382010581 acyl-activating enzyme (AAE) consensus motif; other site 1138382010582 AMP binding site [chemical binding]; other site 1138382010583 active site 1138382010584 CoA binding site [chemical binding]; other site 1138382010585 Fic/DOC family; Region: Fic; cl00960 1138382010586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382010587 D-galactonate transporter; Region: 2A0114; TIGR00893 1138382010588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382010589 phosphoglucomutase; Validated; Region: PRK07564 1138382010590 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1138382010591 active site 1138382010592 substrate binding site [chemical binding]; other site 1138382010593 metal binding site [ion binding]; metal-binding site 1138382010594 camphor resistance protein CrcB; Provisional; Region: PRK14216 1138382010595 camphor resistance protein CrcB; Provisional; Region: PRK14228 1138382010596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138382010597 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138382010598 Protein of unknown function, DUF488; Region: DUF488; cl01246 1138382010599 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382010600 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382010601 active site 1138382010602 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138382010603 Hemerythrin-like domain; Region: Hr-like; cd12108 1138382010604 Fe binding site [ion binding]; other site 1138382010605 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1138382010606 hypothetical protein; Validated; Region: PRK00029 1138382010607 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382010608 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382010609 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1138382010610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010611 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138382010612 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382010613 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1138382010614 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1138382010615 putative active site [active] 1138382010616 catalytic site [active] 1138382010617 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1138382010618 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1138382010619 putative active site [active] 1138382010620 putative active site [active] 1138382010621 catalytic site [active] 1138382010622 catalytic site [active] 1138382010623 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1138382010624 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1138382010625 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382010626 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138382010627 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 1138382010628 NAD binding site [chemical binding]; other site 1138382010629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138382010630 dimerization interface [polypeptide binding]; other site 1138382010631 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382010632 cyclase homology domain; Region: CHD; cd07302 1138382010633 nucleotidyl binding site; other site 1138382010634 metal binding site [ion binding]; metal-binding site 1138382010635 dimer interface [polypeptide binding]; other site 1138382010636 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382010637 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382010638 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138382010639 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138382010640 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138382010641 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382010642 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382010643 [2Fe-2S] cluster binding site [ion binding]; other site 1138382010644 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138382010645 alpha subunit interface [polypeptide binding]; other site 1138382010646 active site 1138382010647 substrate binding site [chemical binding]; other site 1138382010648 Fe binding site [ion binding]; other site 1138382010649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138382010650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382010651 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1138382010652 putative effector binding pocket; other site 1138382010653 dimerization interface [polypeptide binding]; other site 1138382010654 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382010655 phosphopeptide binding site; other site 1138382010656 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382010657 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382010658 phosphopeptide binding site; other site 1138382010659 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1138382010660 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138382010661 Walker A/P-loop; other site 1138382010662 ATP binding site [chemical binding]; other site 1138382010663 Q-loop/lid; other site 1138382010664 ABC transporter signature motif; other site 1138382010665 Walker B; other site 1138382010666 D-loop; other site 1138382010667 H-loop/switch region; other site 1138382010668 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138382010669 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382010670 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382010671 active site 1138382010672 ATP binding site [chemical binding]; other site 1138382010673 substrate binding site [chemical binding]; other site 1138382010674 activation loop (A-loop); other site 1138382010675 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138382010676 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1138382010677 Kelch domain; Region: Kelch; smart00612 1138382010678 Kelch motif; Region: Kelch_1; pfam01344 1138382010679 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138382010680 Kelch motif; Region: Kelch_1; pfam01344 1138382010681 Kelch domain; Region: Kelch; smart00612 1138382010682 Kelch motif; Region: Kelch_6; pfam13964 1138382010683 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138382010684 Kelch motif; Region: Kelch_1; pfam01344 1138382010685 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382010686 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138382010687 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1138382010688 SnoaL-like domain; Region: SnoaL_4; cl17707 1138382010689 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1138382010690 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382010691 acyl-activating enzyme (AAE) consensus motif; other site 1138382010692 AMP binding site [chemical binding]; other site 1138382010693 active site 1138382010694 CoA binding site [chemical binding]; other site 1138382010695 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382010696 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382010697 [2Fe-2S] cluster binding site [ion binding]; other site 1138382010698 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382010699 hydrophobic ligand binding site; other site 1138382010700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382010701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010702 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138382010703 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382010704 enoyl-CoA hydratase; Provisional; Region: PRK07799 1138382010705 substrate binding site [chemical binding]; other site 1138382010706 oxyanion hole (OAH) forming residues; other site 1138382010707 trimer interface [polypeptide binding]; other site 1138382010708 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1138382010709 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1138382010710 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382010711 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382010712 putative active site [active] 1138382010713 putative substrate binding site [chemical binding]; other site 1138382010714 ATP binding site [chemical binding]; other site 1138382010715 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382010716 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382010717 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138382010718 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382010719 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382010720 NAD(P) binding site [chemical binding]; other site 1138382010721 catalytic residues [active] 1138382010722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382010723 Cytochrome P450; Region: p450; cl12078 1138382010724 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382010725 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382010726 NAD binding site [chemical binding]; other site 1138382010727 catalytic Zn binding site [ion binding]; other site 1138382010728 substrate binding site [chemical binding]; other site 1138382010729 structural Zn binding site [ion binding]; other site 1138382010730 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138382010731 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382010732 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cl00482 1138382010733 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1138382010734 SmpB-tmRNA interface; other site 1138382010735 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1138382010736 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1138382010737 FtsX-like permease family; Region: FtsX; pfam02687 1138382010738 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1138382010739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138382010740 Walker A/P-loop; other site 1138382010741 ATP binding site [chemical binding]; other site 1138382010742 Q-loop/lid; other site 1138382010743 ABC transporter signature motif; other site 1138382010744 Walker B; other site 1138382010745 D-loop; other site 1138382010746 H-loop/switch region; other site 1138382010747 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138382010748 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138382010749 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1138382010750 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138382010751 RF-1 domain; Region: RF-1; pfam00472 1138382010752 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1138382010753 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138382010754 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1138382010755 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1138382010756 Binuclear center (active site) [active] 1138382010757 K-pathway; other site 1138382010758 Putative proton exit pathway; other site 1138382010759 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138382010760 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138382010761 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138382010762 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382010763 PPE family; Region: PPE; pfam00823 1138382010764 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382010765 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382010766 PPE family; Region: PPE; pfam00823 1138382010767 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382010768 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1138382010769 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138382010770 active site 1138382010771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382010772 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382010773 active site 1138382010774 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382010775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382010776 active site 1138382010777 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382010778 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382010779 active site 1138382010780 catalytic tetrad [active] 1138382010781 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1138382010782 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1138382010783 NADP binding site [chemical binding]; other site 1138382010784 dimer interface [polypeptide binding]; other site 1138382010785 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138382010786 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138382010787 NAD(P) binding site [chemical binding]; other site 1138382010788 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1138382010789 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382010790 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138382010791 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382010792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382010793 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1138382010794 active site 1138382010795 catalytic residues [active] 1138382010796 metal binding site [ion binding]; metal-binding site 1138382010797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382010799 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382010800 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382010801 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382010802 active site 1138382010803 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382010804 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382010805 putative active site [active] 1138382010806 putative substrate binding site [chemical binding]; other site 1138382010807 ATP binding site [chemical binding]; other site 1138382010808 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1138382010809 YceI-like domain; Region: YceI; pfam04264 1138382010810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1138382010811 active site 1138382010812 phosphorylation site [posttranslational modification] 1138382010813 intermolecular recognition site; other site 1138382010814 dimerization interface [polypeptide binding]; other site 1138382010815 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1138382010816 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1138382010817 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1138382010818 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1138382010819 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1138382010820 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1138382010821 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1138382010822 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1138382010823 putative dimer interface [polypeptide binding]; other site 1138382010824 [2Fe-2S] cluster binding site [ion binding]; other site 1138382010825 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1138382010826 SLBB domain; Region: SLBB; pfam10531 1138382010827 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1138382010828 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1138382010829 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382010830 catalytic loop [active] 1138382010831 iron binding site [ion binding]; other site 1138382010832 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1138382010833 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382010834 molybdopterin cofactor binding site; other site 1138382010835 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1138382010836 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1138382010837 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1138382010838 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1138382010839 4Fe-4S binding domain; Region: Fer4; pfam00037 1138382010840 4Fe-4S binding domain; Region: Fer4; pfam00037 1138382010841 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1138382010842 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1138382010843 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1138382010844 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1138382010845 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138382010846 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1138382010847 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138382010848 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1138382010849 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138382010850 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138382010851 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138382010852 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138382010853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382010854 Walker A motif; other site 1138382010855 ATP binding site [chemical binding]; other site 1138382010856 Walker B motif; other site 1138382010857 arginine finger; other site 1138382010858 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138382010859 classical (c) SDRs; Region: SDR_c; cd05233 1138382010860 NAD(P) binding site [chemical binding]; other site 1138382010861 active site 1138382010862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382010863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382010864 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382010865 putative active site [active] 1138382010866 putative substrate binding site [chemical binding]; other site 1138382010867 ATP binding site [chemical binding]; other site 1138382010868 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382010869 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1138382010870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382010871 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382010872 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382010873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382010874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138382010875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382010876 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138382010877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382010878 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382010879 anti sigma factor interaction site; other site 1138382010880 regulatory phosphorylation site [posttranslational modification]; other site 1138382010881 hydroperoxidase II; Provisional; Region: katE; PRK11249 1138382010882 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1138382010883 tetramer interface [polypeptide binding]; other site 1138382010884 heme binding pocket [chemical binding]; other site 1138382010885 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1138382010886 domain interactions; other site 1138382010887 transcription termination factor Rho; Provisional; Region: PRK12678 1138382010888 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382010889 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1138382010890 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1138382010891 putative catalytic site [active] 1138382010892 putative metal binding site [ion binding]; other site 1138382010893 putative phosphate binding site [ion binding]; other site 1138382010894 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138382010895 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138382010896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382010897 NAD(P) binding site [chemical binding]; other site 1138382010898 active site 1138382010899 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 1138382010900 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138382010901 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 1138382010902 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1138382010903 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1138382010904 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1138382010905 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1138382010906 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1138382010907 active site 1138382010908 DNA binding site [nucleotide binding] 1138382010909 Int/Topo IB signature motif; other site 1138382010910 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1138382010911 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1138382010912 PYR/PP interface [polypeptide binding]; other site 1138382010913 dimer interface [polypeptide binding]; other site 1138382010914 tetramer interface [polypeptide binding]; other site 1138382010915 TPP binding site [chemical binding]; other site 1138382010916 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382010917 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1138382010918 TPP-binding site [chemical binding]; other site 1138382010919 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1138382010920 Fe-S cluster binding site [ion binding]; other site 1138382010921 active site 1138382010922 Hemerythrin-like domain; Region: Hr-like; cd12108 1138382010923 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138382010924 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138382010925 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382010926 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382010927 active site 1138382010928 catalytic tetrad [active] 1138382010929 classical (c) SDRs; Region: SDR_c; cd05233 1138382010930 NAD(P) binding site [chemical binding]; other site 1138382010931 active site 1138382010932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138382010933 PAS fold; Region: PAS_3; pfam08447 1138382010934 putative active site [active] 1138382010935 heme pocket [chemical binding]; other site 1138382010936 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138382010937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138382010938 metal binding site [ion binding]; metal-binding site 1138382010939 active site 1138382010940 I-site; other site 1138382010941 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1138382010942 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1138382010943 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1138382010944 active site 1138382010945 catalytic site [active] 1138382010946 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1138382010947 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382010948 NAD binding site [chemical binding]; other site 1138382010949 catalytic Zn binding site [ion binding]; other site 1138382010950 structural Zn binding site [ion binding]; other site 1138382010951 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138382010952 GAF domain; Region: GAF; pfam01590 1138382010953 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382010954 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138382010955 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1138382010956 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1138382010957 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138382010958 DNA binding residues [nucleotide binding] 1138382010959 putative dimer interface [polypeptide binding]; other site 1138382010960 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138382010961 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138382010962 putative dimer interface [polypeptide binding]; other site 1138382010963 PAS fold; Region: PAS_3; pfam08447 1138382010964 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382010965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138382010966 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382010967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382010968 active site 1138382010969 phosphorylation site [posttranslational modification] 1138382010970 intermolecular recognition site; other site 1138382010971 dimerization interface [polypeptide binding]; other site 1138382010972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382010973 DNA binding residues [nucleotide binding] 1138382010974 dimerization interface [polypeptide binding]; other site 1138382010975 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138382010976 yiaA/B two helix domain; Region: YiaAB; cl01759 1138382010977 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138382010978 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1138382010979 FMN-binding pocket [chemical binding]; other site 1138382010980 flavin binding motif; other site 1138382010981 phosphate binding motif [ion binding]; other site 1138382010982 beta-alpha-beta structure motif; other site 1138382010983 NAD binding pocket [chemical binding]; other site 1138382010984 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382010985 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138382010986 catalytic loop [active] 1138382010987 iron binding site [ion binding]; other site 1138382010988 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382010989 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138382010990 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138382010991 acyl-CoA synthetase; Validated; Region: PRK05850 1138382010992 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138382010993 acyl-activating enzyme (AAE) consensus motif; other site 1138382010994 active site 1138382010995 thioester reductase domain; Region: Thioester-redct; TIGR01746 1138382010996 Male sterility protein; Region: NAD_binding_4; pfam07993 1138382010997 NAD(P) binding site [chemical binding]; other site 1138382010998 active site 1138382010999 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138382011000 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138382011001 short chain dehydrogenase; Provisional; Region: PRK06197 1138382011002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382011003 NAD(P) binding site [chemical binding]; other site 1138382011004 active site 1138382011005 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382011006 mce related protein; Region: MCE; pfam02470 1138382011007 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382011008 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382011009 mce related protein; Region: MCE; pfam02470 1138382011010 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382011011 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1138382011012 catalytic residues [active] 1138382011013 dimer interface [polypeptide binding]; other site 1138382011014 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138382011015 SIR2-like domain; Region: SIR2_2; pfam13289 1138382011016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138382011017 Transposase; Region: HTH_Tnp_1; cl17663 1138382011018 putative transposase OrfB; Reviewed; Region: PHA02517 1138382011019 HTH-like domain; Region: HTH_21; pfam13276 1138382011020 Integrase core domain; Region: rve; pfam00665 1138382011021 Integrase core domain; Region: rve_3; cl15866 1138382011022 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1138382011023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382011024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382011025 non-specific DNA binding site [nucleotide binding]; other site 1138382011026 salt bridge; other site 1138382011027 sequence-specific DNA binding site [nucleotide binding]; other site 1138382011028 Domain of unknown function (DUF955); Region: DUF955; cl01076 1138382011029 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1138382011030 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1138382011031 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382011032 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382011033 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1138382011034 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1138382011035 Flavoprotein; Region: Flavoprotein; pfam02441 1138382011036 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1138382011037 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1138382011038 dimerization interface [polypeptide binding]; other site 1138382011039 DPS ferroxidase diiron center [ion binding]; other site 1138382011040 ion pore; other site 1138382011041 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138382011042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382011043 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138382011044 FMN binding site [chemical binding]; other site 1138382011045 Nitroreductase family; Region: Nitroreductase; pfam00881 1138382011046 dimer interface [polypeptide binding]; other site 1138382011047 choline dehydrogenase; Validated; Region: PRK02106 1138382011048 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138382011049 AAA ATPase domain; Region: AAA_16; pfam13191 1138382011050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382011051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382011052 DNA binding residues [nucleotide binding] 1138382011053 dimerization interface [polypeptide binding]; other site 1138382011054 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138382011055 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138382011056 conserved cys residue [active] 1138382011057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382011058 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138382011059 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138382011060 NADP binding site [chemical binding]; other site 1138382011061 active site 1138382011062 steroid binding site; other site 1138382011063 FMN binding site [chemical binding]; other site 1138382011064 Nitroreductase family; Region: Nitroreductase; pfam00881 1138382011065 dimer interface [polypeptide binding]; other site 1138382011066 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1138382011067 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138382011068 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138382011069 conserved cys residue [active] 1138382011070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138382011071 hypothetical protein; Validated; Region: PRK00068 1138382011072 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1138382011073 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1138382011074 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138382011075 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1138382011076 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1138382011077 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138382011078 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138382011079 ABC1 family; Region: ABC1; pfam03109 1138382011080 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138382011081 active site 1138382011082 ATP binding site [chemical binding]; other site 1138382011083 Transcription factor WhiB; Region: Whib; pfam02467 1138382011084 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138382011085 Part of AAA domain; Region: AAA_19; pfam13245 1138382011086 Family description; Region: UvrD_C_2; pfam13538 1138382011087 HRDC domain; Region: HRDC; pfam00570 1138382011088 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138382011089 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1138382011090 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1138382011091 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1138382011092 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1138382011093 putative NADH binding site [chemical binding]; other site 1138382011094 putative active site [active] 1138382011095 nudix motif; other site 1138382011096 putative metal binding site [ion binding]; other site 1138382011097 Ion channel; Region: Ion_trans_2; pfam07885 1138382011098 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1138382011099 TrkA-N domain; Region: TrkA_N; pfam02254 1138382011100 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138382011101 Part of AAA domain; Region: AAA_19; pfam13245 1138382011102 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1138382011103 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1138382011104 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138382011105 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1138382011106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382011107 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382011108 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138382011109 catalytic site [active] 1138382011110 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138382011111 active site 1138382011112 DNA binding site [nucleotide binding] 1138382011113 TIGR02569 family protein; Region: TIGR02569_actnb 1138382011114 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1138382011115 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1138382011116 ATP binding site [chemical binding]; other site 1138382011117 substrate interface [chemical binding]; other site 1138382011118 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1138382011119 active site residue [active] 1138382011120 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1138382011121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382011122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382011123 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1138382011124 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1138382011125 dinuclear metal binding motif [ion binding]; other site 1138382011126 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1138382011127 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138382011128 ATP binding site [chemical binding]; other site 1138382011129 Mg++ binding site [ion binding]; other site 1138382011130 motif III; other site 1138382011131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382011132 nucleotide binding region [chemical binding]; other site 1138382011133 ATP-binding site [chemical binding]; other site 1138382011134 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382011135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382011136 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382011137 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138382011138 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138382011139 P-loop; other site 1138382011140 Magnesium ion binding site [ion binding]; other site 1138382011141 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138382011142 Magnesium ion binding site [ion binding]; other site 1138382011143 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382011144 catalytic core [active] 1138382011145 isochorismate synthase DhbC; Validated; Region: PRK06923 1138382011146 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138382011147 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138382011148 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138382011149 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138382011150 Transcription factor WhiB; Region: Whib; pfam02467 1138382011151 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1138382011152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1138382011153 Histidine kinase; Region: HisKA_2; pfam07568 1138382011154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382011155 ATP binding site [chemical binding]; other site 1138382011156 Mg2+ binding site [ion binding]; other site 1138382011157 G-X-G motif; other site 1138382011158 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138382011159 carboxyltransferase (CT) interaction site; other site 1138382011160 biotinylation site [posttranslational modification]; other site 1138382011161 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1138382011162 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1138382011163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382011164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382011165 DNA binding residues [nucleotide binding] 1138382011166 short chain dehydrogenase; Provisional; Region: PRK08278 1138382011167 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1138382011168 NAD(P) binding site [chemical binding]; other site 1138382011169 homodimer interface [polypeptide binding]; other site 1138382011170 active site 1138382011171 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1138382011172 putative deacylase active site [active] 1138382011173 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382011174 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138382011175 NAD(P) binding site [chemical binding]; other site 1138382011176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382011177 active site 1138382011178 metal binding site [ion binding]; metal-binding site 1138382011179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1138382011180 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138382011181 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138382011182 short chain dehydrogenase; Provisional; Region: PRK07856 1138382011183 classical (c) SDRs; Region: SDR_c; cd05233 1138382011184 NAD(P) binding site [chemical binding]; other site 1138382011185 active site 1138382011186 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382011187 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382011188 classical (c) SDRs; Region: SDR_c; cd05233 1138382011189 NAD(P) binding site [chemical binding]; other site 1138382011190 active site 1138382011191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382011192 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382011193 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1138382011194 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1138382011195 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1138382011196 hinge; other site 1138382011197 active site 1138382011198 Predicted GTPases [General function prediction only]; Region: COG1162 1138382011199 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1138382011200 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1138382011201 GTP/Mg2+ binding site [chemical binding]; other site 1138382011202 G4 box; other site 1138382011203 G5 box; other site 1138382011204 G1 box; other site 1138382011205 Switch I region; other site 1138382011206 G2 box; other site 1138382011207 G3 box; other site 1138382011208 Switch II region; other site 1138382011209 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138382011210 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138382011211 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138382011212 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382011213 dimer interface [polypeptide binding]; other site 1138382011214 active site 1138382011215 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1138382011216 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1138382011217 putative active site [active] 1138382011218 catalytic triad [active] 1138382011219 putative dimer interface [polypeptide binding]; other site 1138382011220 Domain of unknown function DUF302; Region: DUF302; pfam03625 1138382011221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382011222 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1138382011223 Zn binding site [ion binding]; other site 1138382011224 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138382011225 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138382011226 putative di-iron ligands [ion binding]; other site 1138382011227 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138382011228 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138382011229 FAD binding pocket [chemical binding]; other site 1138382011230 FAD binding motif [chemical binding]; other site 1138382011231 phosphate binding motif [ion binding]; other site 1138382011232 beta-alpha-beta structure motif; other site 1138382011233 NAD binding pocket [chemical binding]; other site 1138382011234 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382011235 catalytic loop [active] 1138382011236 iron binding site [ion binding]; other site 1138382011237 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382011238 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382011239 NnrU protein; Region: NnrU; cl17713 1138382011240 Phospholipid methyltransferase; Region: PEMT; cl17370 1138382011241 HD domain; Region: HD_5; pfam13487 1138382011242 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138382011243 Zn2+ binding site [ion binding]; other site 1138382011244 Mg2+ binding site [ion binding]; other site 1138382011245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382011246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382011247 DNA binding residues [nucleotide binding] 1138382011248 dimerization interface [polypeptide binding]; other site 1138382011249 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1138382011250 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1138382011251 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1138382011252 30S subunit binding site; other site 1138382011253 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1138382011254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382011255 active site 1138382011256 lipoprotein LpqB; Provisional; Region: PRK13616 1138382011257 Sporulation and spore germination; Region: Germane; pfam10646 1138382011258 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1138382011259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138382011260 dimerization interface [polypeptide binding]; other site 1138382011261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382011262 dimer interface [polypeptide binding]; other site 1138382011263 phosphorylation site [posttranslational modification] 1138382011264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382011265 ATP binding site [chemical binding]; other site 1138382011266 Mg2+ binding site [ion binding]; other site 1138382011267 G-X-G motif; other site 1138382011268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382011269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382011270 active site 1138382011271 phosphorylation site [posttranslational modification] 1138382011272 intermolecular recognition site; other site 1138382011273 dimerization interface [polypeptide binding]; other site 1138382011274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382011275 DNA binding site [nucleotide binding] 1138382011276 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1138382011277 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1138382011278 TMP-binding site; other site 1138382011279 ATP-binding site [chemical binding]; other site 1138382011280 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1138382011281 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1138382011282 homotetramer interface [polypeptide binding]; other site 1138382011283 ligand binding site [chemical binding]; other site 1138382011284 catalytic site [active] 1138382011285 NAD binding site [chemical binding]; other site 1138382011286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382011287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382011288 Rubredoxin [Energy production and conversion]; Region: COG1773 1138382011289 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138382011290 iron binding site [ion binding]; other site 1138382011291 Rubredoxin [Energy production and conversion]; Region: COG1773 1138382011292 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138382011293 iron binding site [ion binding]; other site 1138382011294 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1138382011295 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138382011296 Di-iron ligands [ion binding]; other site 1138382011297 amino acid transporter; Region: 2A0306; TIGR00909 1138382011298 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138382011299 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138382011300 hypothetical protein; Provisional; Region: PRK07236 1138382011301 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1138382011302 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138382011303 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138382011304 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1138382011305 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1138382011306 active site 1138382011307 substrate binding site [chemical binding]; other site 1138382011308 metal binding site [ion binding]; metal-binding site 1138382011309 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1138382011310 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1138382011311 Transcription factor WhiB; Region: Whib; pfam02467 1138382011312 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1138382011313 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1138382011314 phosphate binding site [ion binding]; other site 1138382011315 dimer interface [polypeptide binding]; other site 1138382011316 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1138382011317 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1138382011318 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1138382011319 FMN binding site [chemical binding]; other site 1138382011320 dimer interface [polypeptide binding]; other site 1138382011321 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1138382011322 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138382011323 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1138382011324 nudix motif; other site 1138382011325 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1138382011326 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1138382011327 active site 1138382011328 Substrate binding site; other site 1138382011329 Mg++ binding site; other site 1138382011330 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1138382011331 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138382011332 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1138382011333 Probable Catalytic site; other site 1138382011334 metal-binding site 1138382011335 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1138382011336 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138382011337 NADP binding site [chemical binding]; other site 1138382011338 active site 1138382011339 putative substrate binding site [chemical binding]; other site 1138382011340 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138382011341 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138382011342 TIGR03089 family protein; Region: TIGR03089 1138382011343 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138382011344 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138382011345 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138382011346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1138382011347 active site 1138382011348 motif I; other site 1138382011349 motif II; other site 1138382011350 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138382011351 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382011352 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382011353 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382011354 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382011355 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382011356 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382011357 active site 1138382011358 ATP binding site [chemical binding]; other site 1138382011359 substrate binding site [chemical binding]; other site 1138382011360 activation loop (A-loop); other site 1138382011361 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138382011362 NHL repeat; Region: NHL; pfam01436 1138382011363 NHL repeat; Region: NHL; pfam01436 1138382011364 NHL repeat; Region: NHL; pfam01436 1138382011365 NHL repeat; Region: NHL; pfam01436 1138382011366 NHL repeat; Region: NHL; pfam01436 1138382011367 PBP superfamily domain; Region: PBP_like_2; cl17296 1138382011368 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 1138382011369 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138382011370 Walker A/P-loop; other site 1138382011371 ATP binding site [chemical binding]; other site 1138382011372 Q-loop/lid; other site 1138382011373 ABC transporter signature motif; other site 1138382011374 Walker B; other site 1138382011375 D-loop; other site 1138382011376 H-loop/switch region; other site 1138382011377 PBP superfamily domain; Region: PBP_like_2; cl17296 1138382011378 PBP superfamily domain; Region: PBP_like_2; cl17296 1138382011379 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138382011380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382011381 dimer interface [polypeptide binding]; other site 1138382011382 conserved gate region; other site 1138382011383 putative PBP binding loops; other site 1138382011384 ABC-ATPase subunit interface; other site 1138382011385 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138382011386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138382011387 dimer interface [polypeptide binding]; other site 1138382011388 conserved gate region; other site 1138382011389 ABC-ATPase subunit interface; other site 1138382011390 Response regulator receiver domain; Region: Response_reg; pfam00072 1138382011391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382011392 active site 1138382011393 phosphorylation site [posttranslational modification] 1138382011394 intermolecular recognition site; other site 1138382011395 dimerization interface [polypeptide binding]; other site 1138382011396 CHASE3 domain; Region: CHASE3; pfam05227 1138382011397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382011398 dimer interface [polypeptide binding]; other site 1138382011399 phosphorylation site [posttranslational modification] 1138382011400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382011401 ATP binding site [chemical binding]; other site 1138382011402 Mg2+ binding site [ion binding]; other site 1138382011403 G-X-G motif; other site 1138382011404 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138382011405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382011406 active site 1138382011407 phosphorylation site [posttranslational modification] 1138382011408 intermolecular recognition site; other site 1138382011409 dimerization interface [polypeptide binding]; other site 1138382011410 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138382011411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382011412 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1138382011413 FAD binding site [chemical binding]; other site 1138382011414 homotetramer interface [polypeptide binding]; other site 1138382011415 substrate binding pocket [chemical binding]; other site 1138382011416 catalytic base [active] 1138382011417 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1138382011418 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1138382011419 ATP-grasp domain; Region: ATP-grasp; pfam02222 1138382011420 Predicted membrane protein [Function unknown]; Region: COG2246 1138382011421 GtrA-like protein; Region: GtrA; pfam04138 1138382011422 Bacterial PH domain; Region: DUF304; pfam03703 1138382011423 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1138382011424 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1138382011425 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1138382011426 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1138382011427 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138382011428 acyl-CoA synthetase; Provisional; Region: PRK13388 1138382011429 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382011430 acyl-activating enzyme (AAE) consensus motif; other site 1138382011431 AMP binding site [chemical binding]; other site 1138382011432 active site 1138382011433 CoA binding site [chemical binding]; other site 1138382011434 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382011435 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138382011436 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138382011437 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138382011438 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138382011439 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1138382011440 active site 1138382011441 dimer interface [polypeptide binding]; other site 1138382011442 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138382011443 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138382011444 active site residue [active] 1138382011445 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138382011446 active site residue [active] 1138382011447 Fe-S metabolism associated domain; Region: SufE; cl00951 1138382011448 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1138382011449 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138382011450 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138382011451 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138382011452 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138382011453 carboxyltransferase (CT) interaction site; other site 1138382011454 biotinylation site [posttranslational modification]; other site 1138382011455 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382011456 anti sigma factor interaction site; other site 1138382011457 regulatory phosphorylation site [posttranslational modification]; other site 1138382011458 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1138382011459 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382011460 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138382011461 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382011462 DNA binding residues [nucleotide binding] 1138382011463 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138382011464 L-lysine aminotransferase; Provisional; Region: PRK08297 1138382011465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138382011466 inhibitor-cofactor binding pocket; inhibition site 1138382011467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382011468 catalytic residue [active] 1138382011469 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1138382011470 AsnC family; Region: AsnC_trans_reg; pfam01037 1138382011471 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1138382011472 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382011473 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382011474 NAD(P) binding site [chemical binding]; other site 1138382011475 catalytic residues [active] 1138382011476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382011477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138382011478 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1138382011479 ATP binding site [chemical binding]; other site 1138382011480 putative Mg++ binding site [ion binding]; other site 1138382011481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138382011482 nucleotide binding region [chemical binding]; other site 1138382011483 ATP-binding site [chemical binding]; other site 1138382011484 DEAD/H associated; Region: DEAD_assoc; pfam08494 1138382011485 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138382011486 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1138382011487 putative DNA binding site [nucleotide binding]; other site 1138382011488 catalytic residue [active] 1138382011489 putative H2TH interface [polypeptide binding]; other site 1138382011490 putative catalytic residues [active] 1138382011491 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138382011492 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138382011493 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138382011494 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382011495 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1138382011496 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1138382011497 oligomer interface [polypeptide binding]; other site 1138382011498 metal binding site [ion binding]; metal-binding site 1138382011499 metal binding site [ion binding]; metal-binding site 1138382011500 putative Cl binding site [ion binding]; other site 1138382011501 aspartate ring; other site 1138382011502 basic sphincter; other site 1138382011503 hydrophobic gate; other site 1138382011504 periplasmic entrance; other site 1138382011505 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382011506 PPE family; Region: PPE; pfam00823 1138382011507 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382011508 PPE family; Region: PPE; pfam00823 1138382011509 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138382011510 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138382011511 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1138382011512 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1138382011513 active site 1138382011514 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1138382011515 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1138382011516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382011517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382011518 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138382011519 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138382011520 putative active site pocket [active] 1138382011521 dimerization interface [polypeptide binding]; other site 1138382011522 putative catalytic residue [active] 1138382011523 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382011524 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1138382011525 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1138382011526 metal binding site [ion binding]; metal-binding site 1138382011527 putative dimer interface [polypeptide binding]; other site 1138382011528 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1138382011529 amidohydrolase; Region: amidohydrolases; TIGR01891 1138382011530 metal binding site [ion binding]; metal-binding site 1138382011531 Cutinase; Region: Cutinase; pfam01083 1138382011532 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1138382011533 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1138382011534 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1138382011535 active site 1138382011536 substrate binding site [chemical binding]; other site 1138382011537 metal binding site [ion binding]; metal-binding site 1138382011538 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138382011539 hypothetical protein; Provisional; Region: PRK13685 1138382011540 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1138382011541 metal ion-dependent adhesion site (MIDAS); other site 1138382011542 hypothetical protein; Provisional; Region: PRK13685 1138382011543 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1138382011544 metal ion-dependent adhesion site (MIDAS); other site 1138382011545 Cupin domain; Region: Cupin_2; cl17218 1138382011546 Cupin domain; Region: Cupin_2; pfam07883 1138382011547 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138382011548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382011549 DNA-binding site [nucleotide binding]; DNA binding site 1138382011550 FCD domain; Region: FCD; pfam07729 1138382011551 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1138382011552 adenosine deaminase; Provisional; Region: PRK09358 1138382011553 active site 1138382011554 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1138382011555 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1138382011556 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1138382011557 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1138382011558 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1138382011559 active site 1138382011560 catalytic motif [active] 1138382011561 Zn binding site [ion binding]; other site 1138382011562 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1138382011563 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138382011564 putative proximal heme binding site [chemical binding]; other site 1138382011565 putative SdhD-like interface [polypeptide binding]; other site 1138382011566 putative distal heme binding site [chemical binding]; other site 1138382011567 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1138382011568 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138382011569 putative proximal heme binding site [chemical binding]; other site 1138382011570 putative SdhC-like subunit interface [polypeptide binding]; other site 1138382011571 putative distal heme binding site [chemical binding]; other site 1138382011572 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1138382011573 L-aspartate oxidase; Provisional; Region: PRK06175 1138382011574 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138382011575 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1138382011576 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1138382011577 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382011578 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138382011579 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1138382011580 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138382011581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382011582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382011583 DNA binding residues [nucleotide binding] 1138382011584 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382011585 hypothetical protein; Provisional; Region: PRK06541 1138382011586 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138382011587 inhibitor-cofactor binding pocket; inhibition site 1138382011588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382011589 catalytic residue [active] 1138382011590 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138382011591 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138382011592 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1138382011593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382011594 putative substrate translocation pore; other site 1138382011595 Amidohydrolase; Region: Amidohydro_4; pfam13147 1138382011596 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382011597 active site 1138382011598 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1138382011599 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1138382011600 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1138382011601 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1138382011602 active site 1138382011603 HIGH motif; other site 1138382011604 dimer interface [polypeptide binding]; other site 1138382011605 KMSKS motif; other site 1138382011606 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382011607 isocitrate dehydrogenase; Validated; Region: PRK08299 1138382011608 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1138382011609 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1138382011610 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1138382011611 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138382011612 homodimer interface [polypeptide binding]; other site 1138382011613 substrate-cofactor binding pocket; other site 1138382011614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382011615 catalytic residue [active] 1138382011616 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1138382011617 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1138382011618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382011619 S-adenosylmethionine binding site [chemical binding]; other site 1138382011620 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382011621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1138382011622 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382011623 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382011624 active site 1138382011625 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382011626 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1138382011627 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1138382011628 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1138382011629 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1138382011630 homodimer interface [polypeptide binding]; other site 1138382011631 NADP binding site [chemical binding]; other site 1138382011632 substrate binding site [chemical binding]; other site 1138382011633 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138382011634 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138382011635 active site 1138382011636 FMN binding site [chemical binding]; other site 1138382011637 substrate binding site [chemical binding]; other site 1138382011638 putative catalytic residue [active] 1138382011639 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382011640 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382011641 phosphopeptide binding site; other site 1138382011642 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382011643 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382011644 phosphopeptide binding site; other site 1138382011645 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138382011646 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138382011647 Walker A/P-loop; other site 1138382011648 ATP binding site [chemical binding]; other site 1138382011649 Q-loop/lid; other site 1138382011650 ABC transporter signature motif; other site 1138382011651 Walker B; other site 1138382011652 D-loop; other site 1138382011653 H-loop/switch region; other site 1138382011654 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138382011655 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138382011656 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382011657 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382011658 phosphopeptide binding site; other site 1138382011659 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138382011660 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138382011661 phosphopeptide binding site; other site 1138382011662 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138382011663 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138382011664 Walker A/P-loop; other site 1138382011665 ATP binding site [chemical binding]; other site 1138382011666 Q-loop/lid; other site 1138382011667 ABC transporter signature motif; other site 1138382011668 Walker B; other site 1138382011669 D-loop; other site 1138382011670 H-loop/switch region; other site 1138382011671 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382011672 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1138382011673 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1138382011674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138382011675 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138382011676 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1138382011677 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1138382011678 G1 box; other site 1138382011679 GTP/Mg2+ binding site [chemical binding]; other site 1138382011680 G2 box; other site 1138382011681 Switch I region; other site 1138382011682 G3 box; other site 1138382011683 Switch II region; other site 1138382011684 G4 box; other site 1138382011685 G5 box; other site 1138382011686 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1138382011687 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1138382011688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382011689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382011690 ATP binding site [chemical binding]; other site 1138382011691 Mg2+ binding site [ion binding]; other site 1138382011692 G-X-G motif; other site 1138382011693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382011694 S-adenosylmethionine binding site [chemical binding]; other site 1138382011695 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1138382011696 YCII-related domain; Region: YCII; cl00999 1138382011697 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138382011698 FMN binding site [chemical binding]; other site 1138382011699 dimer interface [polypeptide binding]; other site 1138382011700 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1138382011701 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1138382011702 active site 1138382011703 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138382011704 generic binding surface II; other site 1138382011705 generic binding surface I; other site 1138382011706 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1138382011707 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1138382011708 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382011709 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138382011710 dimer interaction site [polypeptide binding]; other site 1138382011711 substrate-binding tunnel; other site 1138382011712 active site 1138382011713 catalytic site [active] 1138382011714 substrate binding site [chemical binding]; other site 1138382011715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382011716 catalytic core [active] 1138382011717 short chain dehydrogenase; Provisional; Region: PRK07201 1138382011718 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1138382011719 putative NAD(P) binding site [chemical binding]; other site 1138382011720 active site 1138382011721 putative substrate binding site [chemical binding]; other site 1138382011722 classical (c) SDRs; Region: SDR_c; cd05233 1138382011723 NAD(P) binding site [chemical binding]; other site 1138382011724 active site 1138382011725 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382011726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382011727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382011728 S-adenosylmethionine binding site [chemical binding]; other site 1138382011729 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1138382011730 active site 1138382011731 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138382011732 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138382011733 dimer interface [polypeptide binding]; other site 1138382011734 active site 1138382011735 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1138382011736 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1138382011737 putative active site [active] 1138382011738 putative substrate binding site [chemical binding]; other site 1138382011739 putative FMN binding site [chemical binding]; other site 1138382011740 putative catalytic residues [active] 1138382011741 DNA Polymerase Y-family; Region: PolY_like; cd03468 1138382011742 DNA binding site [nucleotide binding] 1138382011743 GMP synthase; Reviewed; Region: guaA; PRK00074 1138382011744 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1138382011745 AMP/PPi binding site [chemical binding]; other site 1138382011746 candidate oxyanion hole; other site 1138382011747 catalytic triad [active] 1138382011748 potential glutamine specificity residues [chemical binding]; other site 1138382011749 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1138382011750 ATP Binding subdomain [chemical binding]; other site 1138382011751 Ligand Binding sites [chemical binding]; other site 1138382011752 Dimerization subdomain; other site 1138382011753 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382011754 PPE family; Region: PPE; pfam00823 1138382011755 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382011756 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1138382011757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382011758 motif II; other site 1138382011759 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1138382011760 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1138382011761 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1138382011762 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1138382011763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382011764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382011765 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1138382011766 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138382011767 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1138382011768 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138382011769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138382011770 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138382011771 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1138382011772 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138382011773 phosphate binding site [ion binding]; other site 1138382011774 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1138382011775 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138382011776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1138382011777 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138382011778 active site 1138382011779 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1138382011780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382011781 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1138382011782 DNA binding residues [nucleotide binding] 1138382011783 Transcription factor WhiB; Region: Whib; pfam02467 1138382011784 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138382011785 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138382011786 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1138382011787 [2Fe-2S] cluster binding site [ion binding]; other site 1138382011788 Hemerythrin-like domain; Region: Hr-like; cd12108 1138382011789 Fe binding site [ion binding]; other site 1138382011790 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1138382011791 E-class dimer interface [polypeptide binding]; other site 1138382011792 P-class dimer interface [polypeptide binding]; other site 1138382011793 active site 1138382011794 Cu2+ binding site [ion binding]; other site 1138382011795 Zn2+ binding site [ion binding]; other site 1138382011796 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1138382011797 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138382011798 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138382011799 ring oligomerisation interface [polypeptide binding]; other site 1138382011800 ATP/Mg binding site [chemical binding]; other site 1138382011801 stacking interactions; other site 1138382011802 hinge regions; other site 1138382011803 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1138382011804 oligomerisation interface [polypeptide binding]; other site 1138382011805 mobile loop; other site 1138382011806 roof hairpin; other site 1138382011807 UGMP family protein; Validated; Region: PRK09604 1138382011808 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1138382011809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382011810 Coenzyme A binding pocket [chemical binding]; other site 1138382011811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138382011812 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1138382011813 Glycoprotease family; Region: Peptidase_M22; pfam00814 1138382011814 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1138382011815 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382011816 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382011817 alanine racemase; Reviewed; Region: alr; PRK00053 1138382011818 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1138382011819 active site 1138382011820 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138382011821 dimer interface [polypeptide binding]; other site 1138382011822 substrate binding site [chemical binding]; other site 1138382011823 catalytic residues [active] 1138382011824 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1138382011825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382011826 catalytic residue [active] 1138382011827 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1138382011828 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1138382011829 putative substrate binding site [chemical binding]; other site 1138382011830 putative ATP binding site [chemical binding]; other site 1138382011831 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1138382011832 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1138382011833 glutaminase active site [active] 1138382011834 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1138382011835 dimer interface [polypeptide binding]; other site 1138382011836 active site 1138382011837 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1138382011838 dimer interface [polypeptide binding]; other site 1138382011839 active site 1138382011840 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382011841 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138382011842 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382011843 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1138382011844 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1138382011845 active site 1138382011846 substrate binding site [chemical binding]; other site 1138382011847 metal binding site [ion binding]; metal-binding site 1138382011848 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1138382011849 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1138382011850 23S rRNA interface [nucleotide binding]; other site 1138382011851 L3 interface [polypeptide binding]; other site 1138382011852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138382011853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138382011854 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1138382011855 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138382011856 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382011857 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138382011858 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382011859 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382011860 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 1138382011861 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138382011862 catalytic residues [active] 1138382011863 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1138382011864 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1138382011865 catalytic residues [active] 1138382011866 catalytic nucleophile [active] 1138382011867 Recombinase; Region: Recombinase; pfam07508 1138382011868 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1138382011869 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1138382011870 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 1138382011871 Phage capsid family; Region: Phage_capsid; pfam05065 1138382011872 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138382011873 catalytic residues [active] 1138382011874 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1138382011875 Cutinase; Region: Cutinase; pfam01083 1138382011876 Cutinase; Region: Cutinase; pfam01083 1138382011877 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1138382011878 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1138382011879 active site 1138382011880 dimerization interface 3.5A [polypeptide binding]; other site 1138382011881 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1138382011882 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1138382011883 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1138382011884 alphaNTD homodimer interface [polypeptide binding]; other site 1138382011885 alphaNTD - beta interaction site [polypeptide binding]; other site 1138382011886 alphaNTD - beta' interaction site [polypeptide binding]; other site 1138382011887 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1138382011888 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1138382011889 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1138382011890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138382011891 RNA binding surface [nucleotide binding]; other site 1138382011892 30S ribosomal protein S11; Validated; Region: PRK05309 1138382011893 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1138382011894 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1138382011895 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1138382011896 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1138382011897 rRNA binding site [nucleotide binding]; other site 1138382011898 predicted 30S ribosome binding site; other site 1138382011899 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138382011900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382011901 active site 1138382011902 phosphorylation site [posttranslational modification] 1138382011903 intermolecular recognition site; other site 1138382011904 dimerization interface [polypeptide binding]; other site 1138382011905 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138382011906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382011907 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138382011908 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138382011909 ligand binding site [chemical binding]; other site 1138382011910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138382011911 flexible hinge region; other site 1138382011912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382011913 ATP binding site [chemical binding]; other site 1138382011914 Mg2+ binding site [ion binding]; other site 1138382011915 G-X-G motif; other site 1138382011916 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138382011917 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138382011918 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138382011919 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1138382011920 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1138382011921 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1138382011922 NAD binding site [chemical binding]; other site 1138382011923 substrate binding site [chemical binding]; other site 1138382011924 homodimer interface [polypeptide binding]; other site 1138382011925 active site 1138382011926 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1138382011927 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382011928 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138382011929 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382011930 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138382011931 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1138382011932 active site 1138382011933 metal binding site [ion binding]; metal-binding site 1138382011934 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1138382011935 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1138382011936 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138382011937 iron-sulfur cluster [ion binding]; other site 1138382011938 [2Fe-2S] cluster binding site [ion binding]; other site 1138382011939 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1138382011940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382011941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382011942 DNA binding residues [nucleotide binding] 1138382011943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382011944 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1138382011945 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1138382011946 tetrameric interface [polypeptide binding]; other site 1138382011947 NAD binding site [chemical binding]; other site 1138382011948 catalytic residues [active] 1138382011949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382011950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382011951 active site 1138382011952 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138382011953 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1138382011954 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382011955 MarR family; Region: MarR; pfam01047 1138382011956 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1138382011957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382011958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382011959 homodimer interface [polypeptide binding]; other site 1138382011960 catalytic residue [active] 1138382011961 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1138382011962 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1138382011963 active site 1138382011964 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776 1138382011965 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1138382011966 PYR/PP interface [polypeptide binding]; other site 1138382011967 dimer interface [polypeptide binding]; other site 1138382011968 TPP binding site [chemical binding]; other site 1138382011969 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1138382011970 TPP-binding site [chemical binding]; other site 1138382011971 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138382011972 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1138382011973 Walker A/P-loop; other site 1138382011974 ATP binding site [chemical binding]; other site 1138382011975 Q-loop/lid; other site 1138382011976 ABC transporter signature motif; other site 1138382011977 Walker B; other site 1138382011978 D-loop; other site 1138382011979 H-loop/switch region; other site 1138382011980 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1138382011981 FtsX-like permease family; Region: FtsX; pfam02687 1138382011982 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138382011983 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1138382011984 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138382011985 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382011986 Putative zinc-finger; Region: zf-HC2; pfam13490 1138382011987 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1138382011988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382011989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382011990 DNA binding residues [nucleotide binding] 1138382011991 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138382011992 active site 1138382011993 adenylate kinase; Reviewed; Region: adk; PRK00279 1138382011994 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1138382011995 AMP-binding site [chemical binding]; other site 1138382011996 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1138382011997 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1138382011998 SecY translocase; Region: SecY; pfam00344 1138382011999 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012000 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382012001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138382012002 Coenzyme A binding pocket [chemical binding]; other site 1138382012003 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382012004 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1138382012005 nucleotide binding site [chemical binding]; other site 1138382012006 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1138382012007 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1138382012008 NAD binding site [chemical binding]; other site 1138382012009 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1138382012010 intersubunit interface [polypeptide binding]; other site 1138382012011 active site 1138382012012 Zn2+ binding site [ion binding]; other site 1138382012013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382012014 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138382012015 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382012016 NAD(P) binding site [chemical binding]; other site 1138382012017 classical (c) SDRs; Region: SDR_c; cd05233 1138382012018 NAD(P) binding site [chemical binding]; other site 1138382012019 active site 1138382012020 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012021 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382012022 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012023 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382012024 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012025 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382012026 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1138382012027 tandem repeat interface [polypeptide binding]; other site 1138382012028 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138382012029 oligomer interface [polypeptide binding]; other site 1138382012030 active site residues [active] 1138382012031 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138382012032 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1138382012033 tandem repeat interface [polypeptide binding]; other site 1138382012034 oligomer interface [polypeptide binding]; other site 1138382012035 active site residues [active] 1138382012036 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382012037 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382012038 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1138382012039 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1138382012040 23S rRNA binding site [nucleotide binding]; other site 1138382012041 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1138382012042 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1138382012043 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1138382012044 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1138382012045 5S rRNA interface [nucleotide binding]; other site 1138382012046 L27 interface [polypeptide binding]; other site 1138382012047 23S rRNA interface [nucleotide binding]; other site 1138382012048 L5 interface [polypeptide binding]; other site 1138382012049 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1138382012050 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138382012051 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138382012052 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1138382012053 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1138382012054 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1138382012055 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1138382012056 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1138382012057 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1138382012058 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1138382012059 RNA binding site [nucleotide binding]; other site 1138382012060 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1138382012061 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382012062 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382012063 active site 1138382012064 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138382012065 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1138382012066 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138382012067 Sulfatase; Region: Sulfatase; pfam00884 1138382012068 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1138382012069 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1138382012070 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1138382012071 putative translocon interaction site; other site 1138382012072 signal recognition particle (SRP54) interaction site; other site 1138382012073 L23 interface [polypeptide binding]; other site 1138382012074 trigger factor interaction site; other site 1138382012075 23S rRNA interface [nucleotide binding]; other site 1138382012076 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1138382012077 23S rRNA interface [nucleotide binding]; other site 1138382012078 5S rRNA interface [nucleotide binding]; other site 1138382012079 putative antibiotic binding site [chemical binding]; other site 1138382012080 L25 interface [polypeptide binding]; other site 1138382012081 L27 interface [polypeptide binding]; other site 1138382012082 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1138382012083 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1138382012084 G-X-X-G motif; other site 1138382012085 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1138382012086 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1138382012087 putative translocon binding site; other site 1138382012088 protein-rRNA interface [nucleotide binding]; other site 1138382012089 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1138382012090 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1138382012091 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1138382012092 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1138382012093 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1138382012094 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1138382012095 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1138382012096 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1138382012097 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382012098 Cytochrome P450; Region: p450; cl12078 1138382012099 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1138382012100 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138382012101 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1138382012102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138382012103 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1138382012104 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1138382012105 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138382012106 phosphate binding site [ion binding]; other site 1138382012107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138382012108 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1138382012109 FeS/SAM binding site; other site 1138382012110 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1138382012111 mycofactocin precursor; Region: mycofactocin; TIGR03969 1138382012112 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382012113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012114 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1138382012115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382012116 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382012117 active site 1138382012118 catalytic tetrad [active] 1138382012119 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1138382012120 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138382012121 active site 1138382012122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1138382012123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382012124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382012125 classical (c) SDRs; Region: SDR_c; cd05233 1138382012126 NAD(P) binding site [chemical binding]; other site 1138382012127 active site 1138382012128 PE family; Region: PE; pfam00934 1138382012129 elongation factor Tu; Reviewed; Region: PRK00049 1138382012130 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1138382012131 G1 box; other site 1138382012132 GEF interaction site [polypeptide binding]; other site 1138382012133 GTP/Mg2+ binding site [chemical binding]; other site 1138382012134 Switch I region; other site 1138382012135 G2 box; other site 1138382012136 G3 box; other site 1138382012137 Switch II region; other site 1138382012138 G4 box; other site 1138382012139 G5 box; other site 1138382012140 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1138382012141 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1138382012142 Antibiotic Binding Site [chemical binding]; other site 1138382012143 elongation factor G; Reviewed; Region: PRK00007 1138382012144 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1138382012145 G1 box; other site 1138382012146 putative GEF interaction site [polypeptide binding]; other site 1138382012147 GTP/Mg2+ binding site [chemical binding]; other site 1138382012148 Switch I region; other site 1138382012149 G2 box; other site 1138382012150 G3 box; other site 1138382012151 Switch II region; other site 1138382012152 G4 box; other site 1138382012153 G5 box; other site 1138382012154 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138382012155 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138382012156 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138382012157 30S ribosomal protein S7; Validated; Region: PRK05302 1138382012158 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1138382012159 S17 interaction site [polypeptide binding]; other site 1138382012160 S8 interaction site; other site 1138382012161 16S rRNA interaction site [nucleotide binding]; other site 1138382012162 streptomycin interaction site [chemical binding]; other site 1138382012163 23S rRNA interaction site [nucleotide binding]; other site 1138382012164 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1138382012165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382012166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012167 WHG domain; Region: WHG; pfam13305 1138382012168 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138382012169 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138382012170 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382012171 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382012172 substrate binding site [chemical binding]; other site 1138382012173 oxyanion hole (OAH) forming residues; other site 1138382012174 trimer interface [polypeptide binding]; other site 1138382012175 PaaX-like protein; Region: PaaX; pfam07848 1138382012176 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1138382012177 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138382012178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382012179 substrate binding site [chemical binding]; other site 1138382012180 oxyanion hole (OAH) forming residues; other site 1138382012181 trimer interface [polypeptide binding]; other site 1138382012182 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1138382012183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382012184 active site 1138382012185 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138382012186 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382012187 endonuclease IV; Provisional; Region: PRK01060 1138382012188 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1138382012189 AP (apurinic/apyrimidinic) site pocket; other site 1138382012190 DNA interaction; other site 1138382012191 Metal-binding active site; metal-binding site 1138382012192 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1138382012193 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1138382012194 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1138382012195 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1138382012196 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1138382012197 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1138382012198 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138382012199 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1138382012200 G-loop; other site 1138382012201 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138382012202 DNA binding site [nucleotide binding] 1138382012203 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1138382012204 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1138382012205 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1138382012206 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1138382012207 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138382012208 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138382012209 RPB10 interaction site [polypeptide binding]; other site 1138382012210 RPB1 interaction site [polypeptide binding]; other site 1138382012211 RPB11 interaction site [polypeptide binding]; other site 1138382012212 RPB3 interaction site [polypeptide binding]; other site 1138382012213 RPB12 interaction site [polypeptide binding]; other site 1138382012214 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1138382012215 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1138382012216 Walker A/P-loop; other site 1138382012217 ATP binding site [chemical binding]; other site 1138382012218 Q-loop/lid; other site 1138382012219 ABC transporter signature motif; other site 1138382012220 Walker B; other site 1138382012221 D-loop; other site 1138382012222 H-loop/switch region; other site 1138382012223 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138382012224 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138382012225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382012226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012227 WHG domain; Region: WHG; pfam13305 1138382012228 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1138382012229 core dimer interface [polypeptide binding]; other site 1138382012230 peripheral dimer interface [polypeptide binding]; other site 1138382012231 L10 interface [polypeptide binding]; other site 1138382012232 L11 interface [polypeptide binding]; other site 1138382012233 putative EF-Tu interaction site [polypeptide binding]; other site 1138382012234 putative EF-G interaction site [polypeptide binding]; other site 1138382012235 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1138382012236 23S rRNA interface [nucleotide binding]; other site 1138382012237 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1138382012238 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1138382012239 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138382012240 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382012241 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1138382012242 active site 1138382012243 catalytic site [active] 1138382012244 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1138382012245 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1138382012246 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1138382012247 DinB superfamily; Region: DinB_2; pfam12867 1138382012248 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138382012249 DinB superfamily; Region: DinB_2; pfam12867 1138382012250 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138382012251 ABC1 family; Region: ABC1; pfam03109 1138382012252 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1138382012253 active site 1138382012254 ATP binding site [chemical binding]; other site 1138382012255 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382012256 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138382012257 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382012258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012259 S-adenosylmethionine binding site [chemical binding]; other site 1138382012260 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382012261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012262 S-adenosylmethionine binding site [chemical binding]; other site 1138382012263 YCII-related domain; Region: YCII; cl00999 1138382012264 YCII-related domain; Region: YCII; cl00999 1138382012265 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1138382012266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382012267 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138382012268 DNA binding residues [nucleotide binding] 1138382012269 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1138382012270 mRNA/rRNA interface [nucleotide binding]; other site 1138382012271 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1138382012272 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1138382012273 23S rRNA interface [nucleotide binding]; other site 1138382012274 L7/L12 interface [polypeptide binding]; other site 1138382012275 putative thiostrepton binding site; other site 1138382012276 L25 interface [polypeptide binding]; other site 1138382012277 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1138382012278 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1138382012279 putative homodimer interface [polypeptide binding]; other site 1138382012280 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1138382012281 heterodimer interface [polypeptide binding]; other site 1138382012282 homodimer interface [polypeptide binding]; other site 1138382012283 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1138382012284 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138382012285 active site 1138382012286 catalytic site [active] 1138382012287 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1138382012288 active site 1138382012289 catalytic site [active] 1138382012290 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138382012291 active site 1138382012292 catalytic site [active] 1138382012293 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1138382012294 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1138382012295 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138382012296 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382012297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382012298 substrate binding site [chemical binding]; other site 1138382012299 oxyanion hole (OAH) forming residues; other site 1138382012300 trimer interface [polypeptide binding]; other site 1138382012301 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1138382012302 [4Fe-4S] binding site [ion binding]; other site 1138382012303 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1138382012304 molybdopterin cofactor binding site; other site 1138382012305 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1138382012306 molybdopterin cofactor binding site; other site 1138382012307 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138382012308 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1138382012309 active site 1138382012310 nucleophile elbow; other site 1138382012311 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1138382012312 cyanate hydratase; Validated; Region: PRK02866 1138382012313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1138382012314 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1138382012315 oligomer interface [polypeptide binding]; other site 1138382012316 active site 1138382012317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012318 S-adenosylmethionine binding site [chemical binding]; other site 1138382012319 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1138382012320 putative FMN binding site [chemical binding]; other site 1138382012321 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382012322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012323 S-adenosylmethionine binding site [chemical binding]; other site 1138382012324 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1138382012325 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1138382012326 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1138382012327 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1138382012328 Part of AAA domain; Region: AAA_19; pfam13245 1138382012329 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1138382012330 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1138382012331 AAA domain; Region: AAA_30; pfam13604 1138382012332 Family description; Region: UvrD_C_2; pfam13538 1138382012333 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138382012334 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138382012335 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382012336 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382012337 active site 1138382012338 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012339 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382012340 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1138382012341 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1138382012342 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1138382012343 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138382012344 PAS fold; Region: PAS_3; pfam08447 1138382012345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1138382012346 putative active site [active] 1138382012347 heme pocket [chemical binding]; other site 1138382012348 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382012349 galactokinase; Provisional; Region: PRK00555 1138382012350 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1138382012351 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1138382012352 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1138382012353 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1138382012354 dimer interface [polypeptide binding]; other site 1138382012355 active site 1138382012356 Predicted membrane protein [Function unknown]; Region: COG1289 1138382012357 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1138382012358 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382012359 Cytochrome P450; Region: p450; cl12078 1138382012360 hypothetical protein; Provisional; Region: PRK07588 1138382012361 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382012362 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382012363 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382012364 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138382012365 NYN domain; Region: NYN; pfam01936 1138382012366 putative metal binding site [ion binding]; other site 1138382012367 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1138382012368 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382012369 Cytochrome P450; Region: p450; cl12078 1138382012370 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138382012371 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138382012372 Integrase core domain; Region: rve; pfam00665 1138382012373 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138382012374 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138382012375 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138382012376 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382012377 molybdopterin cofactor binding site; other site 1138382012378 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 1138382012379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1138382012380 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1138382012381 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382012382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382012383 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1138382012384 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138382012385 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138382012386 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138382012387 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1138382012388 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138382012389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382012390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382012391 salt bridge; other site 1138382012392 non-specific DNA binding site [nucleotide binding]; other site 1138382012393 sequence-specific DNA binding site [nucleotide binding]; other site 1138382012394 heat shock protein HtpX; Provisional; Region: PRK03072 1138382012395 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138382012396 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138382012397 substrate binding pocket [chemical binding]; other site 1138382012398 chain length determination region; other site 1138382012399 substrate-Mg2+ binding site; other site 1138382012400 catalytic residues [active] 1138382012401 aspartate-rich region 1; other site 1138382012402 active site lid residues [active] 1138382012403 aspartate-rich region 2; other site 1138382012404 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1138382012405 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138382012406 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382012407 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1138382012408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012409 S-adenosylmethionine binding site [chemical binding]; other site 1138382012410 short chain dehydrogenase; Provisional; Region: PRK08263 1138382012411 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138382012412 NADP binding site [chemical binding]; other site 1138382012413 active site 1138382012414 steroid binding site; other site 1138382012415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382012416 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138382012417 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1138382012418 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1138382012419 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1138382012420 dimer interface [polypeptide binding]; other site 1138382012421 tetramer interface [polypeptide binding]; other site 1138382012422 PYR/PP interface [polypeptide binding]; other site 1138382012423 TPP binding site [chemical binding]; other site 1138382012424 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1138382012425 TPP-binding site; other site 1138382012426 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1138382012427 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382012428 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138382012429 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1138382012430 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1138382012431 active site 1138382012432 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138382012433 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138382012434 active site 1138382012435 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138382012436 acyl-CoA synthetase; Validated; Region: PRK06188 1138382012437 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382012438 putative active site [active] 1138382012439 putative CoA binding site [chemical binding]; other site 1138382012440 putative AMP binding site [chemical binding]; other site 1138382012441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138382012442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138382012443 active site 1138382012444 catalytic tetrad [active] 1138382012445 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138382012446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382012447 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1138382012448 substrate binding site [chemical binding]; other site 1138382012449 oxyanion hole (OAH) forming residues; other site 1138382012450 trimer interface [polypeptide binding]; other site 1138382012451 short chain dehydrogenase; Provisional; Region: PRK05866 1138382012452 classical (c) SDRs; Region: SDR_c; cd05233 1138382012453 NAD(P) binding site [chemical binding]; other site 1138382012454 active site 1138382012455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382012456 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382012457 active site 1138382012458 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1138382012459 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138382012460 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382012461 AMP binding site [chemical binding]; other site 1138382012462 active site 1138382012463 CoA binding site [chemical binding]; other site 1138382012464 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1138382012465 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1138382012466 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138382012467 Ligand binding site; other site 1138382012468 Putative Catalytic site; other site 1138382012469 DXD motif; other site 1138382012470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382012471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382012472 NAD(P) binding site [chemical binding]; other site 1138382012473 active site 1138382012474 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1138382012475 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1138382012476 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138382012477 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1138382012478 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1138382012479 dimer interface [polypeptide binding]; other site 1138382012480 active site 1138382012481 CoA binding pocket [chemical binding]; other site 1138382012482 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138382012483 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138382012484 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138382012485 P-loop; other site 1138382012486 Magnesium ion binding site [ion binding]; other site 1138382012487 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1138382012488 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1138382012489 ResB-like family; Region: ResB; pfam05140 1138382012490 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138382012491 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138382012492 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138382012493 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138382012494 catalytic residues [active] 1138382012495 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382012496 catalytic core [active] 1138382012497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138382012498 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1138382012499 inhibitor-cofactor binding pocket; inhibition site 1138382012500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382012501 catalytic residue [active] 1138382012502 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138382012503 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1138382012504 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138382012505 metal binding site [ion binding]; metal-binding site 1138382012506 substrate binding pocket [chemical binding]; other site 1138382012507 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1138382012508 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1138382012509 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1138382012510 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138382012511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382012512 acyl-activating enzyme (AAE) consensus motif; other site 1138382012513 AMP binding site [chemical binding]; other site 1138382012514 active site 1138382012515 CoA binding site [chemical binding]; other site 1138382012516 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138382012517 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138382012518 putative NAD(P) binding site [chemical binding]; other site 1138382012519 active site 1138382012520 putative substrate binding site [chemical binding]; other site 1138382012521 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138382012522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382012523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012524 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138382012525 ABC1 family; Region: ABC1; pfam03109 1138382012526 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138382012527 active site 1138382012528 ATP binding site [chemical binding]; other site 1138382012529 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138382012530 ABC1 family; Region: ABC1; pfam03109 1138382012531 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138382012532 active site 1138382012533 ATP binding site [chemical binding]; other site 1138382012534 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382012535 Cytochrome P450; Region: p450; cl12078 1138382012536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382012537 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138382012538 putative substrate translocation pore; other site 1138382012539 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1138382012540 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1138382012541 active site 1138382012542 dimer interface [polypeptide binding]; other site 1138382012543 non-prolyl cis peptide bond; other site 1138382012544 insertion regions; other site 1138382012545 Predicted esterase [General function prediction only]; Region: COG0627 1138382012546 S-formylglutathione hydrolase; Region: PLN02442 1138382012547 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382012548 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382012549 cyclase homology domain; Region: CHD; cd07302 1138382012550 nucleotidyl binding site; other site 1138382012551 metal binding site [ion binding]; metal-binding site 1138382012552 dimer interface [polypeptide binding]; other site 1138382012553 Predicted ATPase [General function prediction only]; Region: COG3903 1138382012554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382012555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382012556 DNA binding residues [nucleotide binding] 1138382012557 dimerization interface [polypeptide binding]; other site 1138382012558 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138382012559 active site 1138382012560 catalytic triad [active] 1138382012561 oxyanion hole [active] 1138382012562 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382012563 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382012564 anti sigma factor interaction site; other site 1138382012565 regulatory phosphorylation site [posttranslational modification]; other site 1138382012566 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1138382012567 dimer interface [polypeptide binding]; other site 1138382012568 active site 1138382012569 Schiff base residues; other site 1138382012570 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1138382012571 active site 1138382012572 homodimer interface [polypeptide binding]; other site 1138382012573 SAM binding site [chemical binding]; other site 1138382012574 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1138382012575 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138382012576 active site 1138382012577 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1138382012578 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1138382012579 domain interfaces; other site 1138382012580 active site 1138382012581 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1138382012582 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1138382012583 tRNA; other site 1138382012584 putative tRNA binding site [nucleotide binding]; other site 1138382012585 putative NADP binding site [chemical binding]; other site 1138382012586 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1138382012587 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1138382012588 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138382012589 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138382012590 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138382012591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382012592 motif II; other site 1138382012593 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138382012594 active site 1138382012595 catalytic site [active] 1138382012596 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382012597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138382012598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012599 S-adenosylmethionine binding site [chemical binding]; other site 1138382012600 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138382012601 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138382012602 putative acyl-acceptor binding pocket; other site 1138382012603 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138382012604 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1138382012605 putative NAD(P) binding site [chemical binding]; other site 1138382012606 active site 1138382012607 putative substrate binding site [chemical binding]; other site 1138382012608 DNA binding domain, excisionase family; Region: excise; TIGR01764 1138382012609 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1138382012610 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1138382012611 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1138382012612 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138382012613 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382012614 active site 2 [active] 1138382012615 active site 1 [active] 1138382012616 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1138382012617 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138382012618 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1138382012619 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1138382012620 DNA interaction; other site 1138382012621 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 1138382012622 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138382012623 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138382012624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138382012625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382012626 active site 1138382012627 phosphorylation site [posttranslational modification] 1138382012628 intermolecular recognition site; other site 1138382012629 dimerization interface [polypeptide binding]; other site 1138382012630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138382012631 DNA binding site [nucleotide binding] 1138382012632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138382012633 dimer interface [polypeptide binding]; other site 1138382012634 phosphorylation site [posttranslational modification] 1138382012635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138382012636 ATP binding site [chemical binding]; other site 1138382012637 Mg2+ binding site [ion binding]; other site 1138382012638 G-X-G motif; other site 1138382012639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382012640 catalytic core [active] 1138382012641 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138382012642 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1138382012643 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1138382012644 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1138382012645 putative ADP-binding pocket [chemical binding]; other site 1138382012646 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138382012647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382012648 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138382012649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382012650 NAD(P) binding site [chemical binding]; other site 1138382012651 active site 1138382012652 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138382012653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138382012654 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138382012655 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138382012656 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1138382012657 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382012658 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1138382012659 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1138382012660 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1138382012661 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1138382012662 putative active site [active] 1138382012663 catalytic triad [active] 1138382012664 putative dimer interface [polypeptide binding]; other site 1138382012665 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138382012666 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1138382012667 catalytic residue [active] 1138382012668 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1138382012669 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1138382012670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382012671 non-specific DNA binding site [nucleotide binding]; other site 1138382012672 salt bridge; other site 1138382012673 sequence-specific DNA binding site [nucleotide binding]; other site 1138382012674 Predicted membrane protein [Function unknown]; Region: COG2733 1138382012675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382012676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012677 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382012678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012679 S-adenosylmethionine binding site [chemical binding]; other site 1138382012680 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138382012681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382012682 S-adenosylmethionine binding site [chemical binding]; other site 1138382012683 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1138382012684 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138382012685 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138382012686 isocitrate lyase; Provisional; Region: PRK15063 1138382012687 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138382012688 tetramer interface [polypeptide binding]; other site 1138382012689 active site 1138382012690 Mg2+/Mn2+ binding site [ion binding]; other site 1138382012691 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1138382012692 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382012693 active site 2 [active] 1138382012694 active site 1 [active] 1138382012695 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382012696 active site 2 [active] 1138382012697 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138382012698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138382012699 non-specific DNA binding site [nucleotide binding]; other site 1138382012700 salt bridge; other site 1138382012701 sequence-specific DNA binding site [nucleotide binding]; other site 1138382012702 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1138382012703 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138382012704 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138382012705 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138382012706 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382012707 Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; Region: Calpain_III; cl00165 1138382012708 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1138382012709 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1138382012710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382012711 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138382012712 Protein of unknown function (DUF779); Region: DUF779; cl01432 1138382012713 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1138382012714 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382012715 NAD(P) binding site [chemical binding]; other site 1138382012716 catalytic residues [active] 1138382012717 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1138382012718 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382012719 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138382012720 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382012721 substrate binding site [chemical binding]; other site 1138382012722 oxyanion hole (OAH) forming residues; other site 1138382012723 trimer interface [polypeptide binding]; other site 1138382012724 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1138382012725 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1138382012726 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1138382012727 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1138382012728 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138382012729 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138382012730 dimer interface [polypeptide binding]; other site 1138382012731 putative radical transfer pathway; other site 1138382012732 diiron center [ion binding]; other site 1138382012733 tyrosyl radical; other site 1138382012734 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138382012735 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138382012736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382012737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012738 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138382012739 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138382012740 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1138382012741 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138382012742 catalytic residues [active] 1138382012743 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138382012744 DinB superfamily; Region: DinB_2; pfam12867 1138382012745 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1138382012746 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382012747 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138382012748 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1138382012749 active site 1138382012750 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382012751 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382012752 PPE family; Region: PPE; pfam00823 1138382012753 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138382012754 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138382012755 classical (c) SDRs; Region: SDR_c; cd05233 1138382012756 NAD(P) binding site [chemical binding]; other site 1138382012757 active site 1138382012758 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138382012759 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138382012760 ring oligomerisation interface [polypeptide binding]; other site 1138382012761 ATP/Mg binding site [chemical binding]; other site 1138382012762 stacking interactions; other site 1138382012763 hinge regions; other site 1138382012764 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138382012765 active site 1138382012766 Cupin domain; Region: Cupin_2; pfam07883 1138382012767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012768 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138382012769 short chain dehydrogenase; Provisional; Region: PRK06197 1138382012770 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138382012771 putative NAD(P) binding site [chemical binding]; other site 1138382012772 active site 1138382012773 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138382012774 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138382012775 dimer interface [polypeptide binding]; other site 1138382012776 putative functional site; other site 1138382012777 putative MPT binding site; other site 1138382012778 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1138382012779 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1138382012780 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1138382012781 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1138382012782 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1138382012783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382012784 Walker A motif; other site 1138382012785 ATP binding site [chemical binding]; other site 1138382012786 Walker B motif; other site 1138382012787 arginine finger; other site 1138382012788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382012789 Walker A motif; other site 1138382012790 ATP binding site [chemical binding]; other site 1138382012791 Walker B motif; other site 1138382012792 arginine finger; other site 1138382012793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382012794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012795 oxidoreductase; Provisional; Region: PRK06196 1138382012796 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138382012797 putative NAD(P) binding site [chemical binding]; other site 1138382012798 active site 1138382012799 enoyl-CoA hydratase; Provisional; Region: PRK08260 1138382012800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382012801 substrate binding site [chemical binding]; other site 1138382012802 oxyanion hole (OAH) forming residues; other site 1138382012803 trimer interface [polypeptide binding]; other site 1138382012804 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382012805 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382012806 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1138382012807 carboxylate-amine ligase; Provisional; Region: PRK13517 1138382012808 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1138382012809 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1138382012810 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1138382012811 E-class dimer interface [polypeptide binding]; other site 1138382012812 P-class dimer interface [polypeptide binding]; other site 1138382012813 active site 1138382012814 Cu2+ binding site [ion binding]; other site 1138382012815 Zn2+ binding site [ion binding]; other site 1138382012816 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138382012817 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1138382012818 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1138382012819 active site 1138382012820 catalytic residues [active] 1138382012821 metal binding site [ion binding]; metal-binding site 1138382012822 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1138382012823 putative catalytic site [active] 1138382012824 putative phosphate binding site [ion binding]; other site 1138382012825 active site 1138382012826 metal binding site A [ion binding]; metal-binding site 1138382012827 DNA binding site [nucleotide binding] 1138382012828 putative AP binding site [nucleotide binding]; other site 1138382012829 putative metal binding site B [ion binding]; other site 1138382012830 Heavy-metal-associated domain; Region: HMA; pfam00403 1138382012831 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1138382012832 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138382012833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382012834 motif II; other site 1138382012835 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138382012836 PAS fold; Region: PAS_3; pfam08447 1138382012837 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382012838 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1138382012839 ThiC-associated domain; Region: ThiC-associated; pfam13667 1138382012840 ThiC family; Region: ThiC; pfam01964 1138382012841 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1138382012842 dimer interface [polypeptide binding]; other site 1138382012843 substrate binding site [chemical binding]; other site 1138382012844 ATP binding site [chemical binding]; other site 1138382012845 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138382012846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382012847 MarR family; Region: MarR; pfam01047 1138382012848 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138382012849 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382012850 Predicted metalloprotease [General function prediction only]; Region: COG2321 1138382012851 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1138382012852 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138382012853 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138382012854 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012855 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382012856 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138382012857 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138382012858 active site 1138382012859 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012860 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382012861 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138382012862 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138382012863 active site 1138382012864 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138382012865 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138382012866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382012867 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138382012868 NAD(P) binding site [chemical binding]; other site 1138382012869 active site 1138382012870 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138382012871 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1138382012872 PA/protease or protease-like domain interface [polypeptide binding]; other site 1138382012873 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1138382012874 Peptidase family M28; Region: Peptidase_M28; pfam04389 1138382012875 active site 1138382012876 metal binding site [ion binding]; metal-binding site 1138382012877 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1138382012878 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138382012879 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1138382012880 PA/protease or protease-like domain interface [polypeptide binding]; other site 1138382012881 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1138382012882 active site 1138382012883 metal binding site [ion binding]; metal-binding site 1138382012884 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1138382012885 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1138382012886 active site 1138382012887 catalytic triad [active] 1138382012888 oxyanion hole [active] 1138382012889 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1138382012890 ThiS interaction site; other site 1138382012891 putative active site [active] 1138382012892 tetramer interface [polypeptide binding]; other site 1138382012893 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1138382012894 thiS-thiF/thiG interaction site; other site 1138382012895 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1138382012896 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1138382012897 thiamine phosphate binding site [chemical binding]; other site 1138382012898 active site 1138382012899 pyrophosphate binding site [ion binding]; other site 1138382012900 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1138382012901 nudix motif; other site 1138382012902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138382012903 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1138382012904 substrate binding pocket [chemical binding]; other site 1138382012905 membrane-bound complex binding site; other site 1138382012906 hinge residues; other site 1138382012907 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138382012908 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138382012909 active site 1138382012910 ATP binding site [chemical binding]; other site 1138382012911 substrate binding site [chemical binding]; other site 1138382012912 activation loop (A-loop); other site 1138382012913 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138382012914 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138382012915 Integrase core domain; Region: rve; pfam00665 1138382012916 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138382012917 putative active site [active] 1138382012918 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1138382012919 propionate/acetate kinase; Provisional; Region: PRK12379 1138382012920 phosphate acetyltransferase; Reviewed; Region: PRK05632 1138382012921 DRTGG domain; Region: DRTGG; pfam07085 1138382012922 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1138382012923 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1138382012924 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138382012925 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382012926 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138382012927 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382012928 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138382012929 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1138382012930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382012931 NAD(P) binding site [chemical binding]; other site 1138382012932 active site 1138382012933 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1138382012934 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382012935 FAD binding site [chemical binding]; other site 1138382012936 substrate binding pocket [chemical binding]; other site 1138382012937 catalytic base [active] 1138382012938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382012939 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382012940 active site 1138382012941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382012942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382012943 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138382012944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382012945 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1138382012946 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138382012947 homodimer interface [polypeptide binding]; other site 1138382012948 substrate-cofactor binding pocket; other site 1138382012949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382012950 catalytic residue [active] 1138382012951 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1138382012952 active site residue [active] 1138382012953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382012954 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138382012955 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382012956 CoenzymeA binding site [chemical binding]; other site 1138382012957 subunit interaction site [polypeptide binding]; other site 1138382012958 PHB binding site; other site 1138382012959 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1138382012960 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1138382012961 GDP-binding site [chemical binding]; other site 1138382012962 ACT binding site; other site 1138382012963 IMP binding site; other site 1138382012964 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1138382012965 catalytic core [active] 1138382012966 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1138382012967 Peptidase family M50; Region: Peptidase_M50; pfam02163 1138382012968 active site 1138382012969 putative substrate binding region [chemical binding]; other site 1138382012970 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1138382012971 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1138382012972 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1138382012973 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1138382012974 active site 1138382012975 intersubunit interface [polypeptide binding]; other site 1138382012976 zinc binding site [ion binding]; other site 1138382012977 Na+ binding site [ion binding]; other site 1138382012978 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138382012979 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138382012980 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1138382012981 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138382012982 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1138382012983 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1138382012984 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138382012985 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138382012986 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138382012987 active site 1138382012988 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138382012989 classical (c) SDRs; Region: SDR_c; cd05233 1138382012990 NAD(P) binding site [chemical binding]; other site 1138382012991 active site 1138382012992 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382012993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382012994 active site 1138382012995 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1138382012996 Clp amino terminal domain; Region: Clp_N; pfam02861 1138382012997 Clp amino terminal domain; Region: Clp_N; pfam02861 1138382012998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382012999 Walker A motif; other site 1138382013000 ATP binding site [chemical binding]; other site 1138382013001 Walker B motif; other site 1138382013002 arginine finger; other site 1138382013003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382013004 Walker A motif; other site 1138382013005 ATP binding site [chemical binding]; other site 1138382013006 Walker B motif; other site 1138382013007 arginine finger; other site 1138382013008 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138382013009 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138382013010 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1138382013011 heme-binding site [chemical binding]; other site 1138382013012 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1138382013013 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1138382013014 FAD binding pocket [chemical binding]; other site 1138382013015 FAD binding motif [chemical binding]; other site 1138382013016 phosphate binding motif [ion binding]; other site 1138382013017 beta-alpha-beta structure motif; other site 1138382013018 NAD binding pocket [chemical binding]; other site 1138382013019 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1138382013020 active site 1138382013021 catalytic residues [active] 1138382013022 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1138382013023 DNA binding residues [nucleotide binding] 1138382013024 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138382013025 putative dimer interface [polypeptide binding]; other site 1138382013026 chaperone protein DnaJ; Provisional; Region: PRK14279 1138382013027 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138382013028 HSP70 interaction site [polypeptide binding]; other site 1138382013029 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138382013030 Zn binding sites [ion binding]; other site 1138382013031 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138382013032 dimer interface [polypeptide binding]; other site 1138382013033 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1138382013034 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1138382013035 dimer interface [polypeptide binding]; other site 1138382013036 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1138382013037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1138382013038 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382013039 nucleotide binding site [chemical binding]; other site 1138382013040 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1138382013041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382013042 putative substrate translocation pore; other site 1138382013043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382013044 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382013045 nucleotide binding site [chemical binding]; other site 1138382013046 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1138382013047 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1138382013048 4Fe-4S binding domain; Region: Fer4; pfam00037 1138382013049 Cysteine-rich domain; Region: CCG; pfam02754 1138382013050 Cysteine-rich domain; Region: CCG; pfam02754 1138382013051 aminotransferase AlaT; Validated; Region: PRK09265 1138382013052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138382013053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138382013054 homodimer interface [polypeptide binding]; other site 1138382013055 catalytic residue [active] 1138382013056 YibE/F-like protein; Region: YibE_F; pfam07907 1138382013057 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1138382013058 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1138382013059 substrate binding site; other site 1138382013060 tetramer interface; other site 1138382013061 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382013062 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138382013063 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138382013064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382013065 S-adenosylmethionine binding site [chemical binding]; other site 1138382013066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382013067 putative substrate translocation pore; other site 1138382013068 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138382013069 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1138382013070 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1138382013071 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1138382013072 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1138382013073 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138382013074 trimer interface [polypeptide binding]; other site 1138382013075 active site 1138382013076 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138382013077 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382013078 Emopamil binding protein; Region: EBP; pfam05241 1138382013079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138382013080 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138382013081 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138382013082 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382013083 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382013084 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1138382013085 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1138382013086 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1138382013087 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1138382013088 active site 1138382013089 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138382013090 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138382013091 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138382013092 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1138382013093 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138382013094 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138382013095 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1138382013096 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1138382013097 active site 1138382013098 catalytic residues [active] 1138382013099 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1138382013100 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1138382013101 NAD(P) binding site [chemical binding]; other site 1138382013102 substrate binding site [chemical binding]; other site 1138382013103 dimer interface [polypeptide binding]; other site 1138382013104 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138382013105 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138382013106 nucleotide binding site [chemical binding]; other site 1138382013107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013109 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382013110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1138382013111 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1138382013112 active site 1138382013113 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138382013114 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1138382013115 putative FMN binding site [chemical binding]; other site 1138382013116 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138382013117 Sulfatase; Region: Sulfatase; pfam00884 1138382013118 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1138382013119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382013120 S-adenosylmethionine binding site [chemical binding]; other site 1138382013121 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382013122 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382013123 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138382013124 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138382013125 Subtilase family; Region: Peptidase_S8; pfam00082 1138382013126 catalytic residues [active] 1138382013127 catalytic residues [active] 1138382013128 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138382013129 EspG family; Region: ESX-1_EspG; pfam14011 1138382013130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138382013131 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382013132 PPE family; Region: PPE; pfam00823 1138382013133 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138382013134 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382013135 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138382013136 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382013137 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382013138 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138382013139 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138382013140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138382013141 Walker A motif; other site 1138382013142 ATP binding site [chemical binding]; other site 1138382013143 Walker B motif; other site 1138382013144 arginine finger; other site 1138382013145 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382013146 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382013147 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1138382013148 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1138382013149 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138382013150 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1138382013151 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138382013152 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1138382013153 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1138382013154 30S ribosomal protein S18; Provisional; Region: PRK13401 1138382013155 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382013156 PPE family; Region: PPE; pfam00823 1138382013157 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138382013158 Condensation domain; Region: Condensation; pfam00668 1138382013159 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1138382013160 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382013161 Zn binding site [ion binding]; other site 1138382013162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382013165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382013167 active site 1138382013168 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013169 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138382013170 FAD binding site [chemical binding]; other site 1138382013171 substrate binding site [chemical binding]; other site 1138382013172 catalytic base [active] 1138382013173 acyl-CoA synthetase; Validated; Region: PRK07788 1138382013174 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013175 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013176 active site 1138382013177 CoA binding site [chemical binding]; other site 1138382013178 AMP binding site [chemical binding]; other site 1138382013179 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138382013180 nucleotide binding site [chemical binding]; other site 1138382013181 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138382013182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382013183 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138382013184 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1138382013185 intersubunit interface [polypeptide binding]; other site 1138382013186 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1138382013187 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1138382013188 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1138382013189 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138382013190 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1138382013191 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138382013192 active site 1138382013193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1138382013194 DNA binding site [nucleotide binding] 1138382013195 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138382013196 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138382013197 putative active site [active] 1138382013198 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1138382013199 active site 1138382013200 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1138382013201 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1138382013202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382013203 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1138382013204 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138382013205 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138382013206 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138382013207 putative dimer interface [polypeptide binding]; other site 1138382013208 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138382013209 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1138382013210 tetramer interface [polypeptide binding]; other site 1138382013211 active site 1138382013212 Mg2+/Mn2+ binding site [ion binding]; other site 1138382013213 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1138382013214 L-aspartate oxidase; Provisional; Region: PRK06175 1138382013215 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138382013216 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1138382013217 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382013218 catalytic loop [active] 1138382013219 iron binding site [ion binding]; other site 1138382013220 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138382013221 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1138382013222 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1138382013223 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1138382013224 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138382013225 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138382013226 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1138382013227 FAD binding site [chemical binding]; other site 1138382013228 substrate binding site [chemical binding]; other site 1138382013229 catalytic residues [active] 1138382013230 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138382013231 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138382013232 MarR family; Region: MarR_2; pfam12802 1138382013233 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138382013234 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138382013235 active site 1138382013236 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1138382013237 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138382013238 dimer interface [polypeptide binding]; other site 1138382013239 active site 1138382013240 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1138382013241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013242 NAD(P) binding site [chemical binding]; other site 1138382013243 active site 1138382013244 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382013245 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382013246 active site 2 [active] 1138382013247 active site 1 [active] 1138382013248 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1138382013249 Cl- selectivity filter; other site 1138382013250 Cl- binding residues [ion binding]; other site 1138382013251 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1138382013252 pore gating glutamate residue; other site 1138382013253 dimer interface [polypeptide binding]; other site 1138382013254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013256 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138382013257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138382013258 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138382013259 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138382013260 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1138382013261 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1138382013262 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1138382013263 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1138382013264 Lipase maturation factor; Region: LMF1; pfam06762 1138382013265 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1138382013266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138382013267 substrate binding pocket [chemical binding]; other site 1138382013268 membrane-bound complex binding site; other site 1138382013269 hinge residues; other site 1138382013270 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382013271 PPE family; Region: PPE; pfam00823 1138382013272 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382013273 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138382013274 PPE family; Region: PPE; pfam00823 1138382013275 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138382013276 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138382013277 formate dehydrogenase; Provisional; Region: PRK07574 1138382013278 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1138382013279 dimerization interface [polypeptide binding]; other site 1138382013280 ligand binding site [chemical binding]; other site 1138382013281 NAD binding site [chemical binding]; other site 1138382013282 catalytic site [active] 1138382013283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138382013284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382013285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138382013286 dimerization interface [polypeptide binding]; other site 1138382013287 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1138382013288 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1138382013289 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138382013290 putative DNA binding site [nucleotide binding]; other site 1138382013291 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138382013292 putative Zn2+ binding site [ion binding]; other site 1138382013293 Suppression of tumorigenicity 7; Region: ST7; cd11557 1138382013294 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1138382013295 acetolactate synthase; Reviewed; Region: PRK08322 1138382013296 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138382013297 PYR/PP interface [polypeptide binding]; other site 1138382013298 dimer interface [polypeptide binding]; other site 1138382013299 TPP binding site [chemical binding]; other site 1138382013300 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382013301 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1138382013302 TPP-binding site [chemical binding]; other site 1138382013303 dimer interface [polypeptide binding]; other site 1138382013304 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1138382013305 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1138382013306 NAD(P) binding site [chemical binding]; other site 1138382013307 catalytic residues [active] 1138382013308 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1138382013309 active site 1138382013310 diiron metal binding site [ion binding]; other site 1138382013311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013314 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138382013315 active site 1138382013316 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138382013317 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1138382013318 active site 1138382013319 substrate binding pocket [chemical binding]; other site 1138382013320 homodimer interaction site [polypeptide binding]; other site 1138382013321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013322 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138382013323 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013324 AMP binding site [chemical binding]; other site 1138382013325 active site 1138382013326 acyl-activating enzyme (AAE) consensus motif; other site 1138382013327 acyl-activating enzyme (AAE) consensus motif; other site 1138382013328 CoA binding site [chemical binding]; other site 1138382013329 potential frameshift: common BLAST hit: gi|375140365|ref|YP_005001014.1| O-methyltransferase 1138382013330 O-methyltransferase; Region: Methyltransf_2; pfam00891 1138382013331 O-methyltransferase; Region: Methyltransf_2; pfam00891 1138382013332 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382013333 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1138382013334 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138382013335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138382013336 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138382013337 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138382013338 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1138382013339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382013340 S-adenosylmethionine binding site [chemical binding]; other site 1138382013341 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138382013342 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382013343 NAD binding site [chemical binding]; other site 1138382013344 catalytic residues [active] 1138382013345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013347 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138382013348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013349 acyl-activating enzyme (AAE) consensus motif; other site 1138382013350 AMP binding site [chemical binding]; other site 1138382013351 active site 1138382013352 CoA binding site [chemical binding]; other site 1138382013353 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138382013354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013356 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138382013357 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382013358 substrate binding site [chemical binding]; other site 1138382013359 oxyanion hole (OAH) forming residues; other site 1138382013360 trimer interface [polypeptide binding]; other site 1138382013361 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138382013362 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138382013363 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138382013364 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382013365 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382013366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138382013367 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138382013368 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138382013369 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382013370 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382013371 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382013372 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382013373 active site 1138382013374 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382013375 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382013376 active site 2 [active] 1138382013377 active site 1 [active] 1138382013378 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138382013379 active site 2 [active] 1138382013380 active site 1 [active] 1138382013381 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013382 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382013383 active site 1138382013384 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1138382013385 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138382013386 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138382013387 substrate binding site [chemical binding]; other site 1138382013388 oxyanion hole (OAH) forming residues; other site 1138382013389 trimer interface [polypeptide binding]; other site 1138382013390 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138382013391 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013392 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382013393 acyl-activating enzyme (AAE) consensus motif; other site 1138382013394 acyl-activating enzyme (AAE) consensus motif; other site 1138382013395 putative AMP binding site [chemical binding]; other site 1138382013396 putative active site [active] 1138382013397 putative CoA binding site [chemical binding]; other site 1138382013398 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138382013399 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1138382013400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138382013401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138382013402 metal binding site [ion binding]; metal-binding site 1138382013403 active site 1138382013404 I-site; other site 1138382013405 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1138382013406 active site 1138382013407 substrate-binding site [chemical binding]; other site 1138382013408 metal-binding site [ion binding] 1138382013409 GTP binding site [chemical binding]; other site 1138382013410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138382013411 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382013412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382013413 S-adenosylmethionine binding site [chemical binding]; other site 1138382013414 LabA_like proteins; Region: LabA_like; cd06167 1138382013415 putative metal binding site [ion binding]; other site 1138382013416 MMPL family; Region: MMPL; pfam03176 1138382013417 MMPL family; Region: MMPL; pfam03176 1138382013418 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1138382013419 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1138382013420 Predicted integral membrane protein [Function unknown]; Region: COG0392 1138382013421 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138382013422 Protein export membrane protein; Region: SecD_SecF; cl14618 1138382013423 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1138382013424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1138382013425 non-specific DNA binding site [nucleotide binding]; other site 1138382013426 salt bridge; other site 1138382013427 sequence-specific DNA binding site [nucleotide binding]; other site 1138382013428 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1138382013429 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1138382013430 active site 1138382013431 Zn binding site [ion binding]; other site 1138382013432 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138382013433 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382013434 molybdopterin cofactor binding site; other site 1138382013435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138382013436 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138382013437 putative molybdopterin cofactor binding site; other site 1138382013438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138382013441 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138382013442 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138382013443 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1138382013444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138382013445 putative substrate translocation pore; other site 1138382013446 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1138382013447 putative homodimer interface [polypeptide binding]; other site 1138382013448 putative homotetramer interface [polypeptide binding]; other site 1138382013449 putative allosteric switch controlling residues; other site 1138382013450 putative metal binding site [ion binding]; other site 1138382013451 putative homodimer-homodimer interface [polypeptide binding]; other site 1138382013452 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1138382013453 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1138382013454 SPW repeat; Region: SPW; pfam03779 1138382013455 SPW repeat; Region: SPW; pfam03779 1138382013456 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138382013457 FMN binding site [chemical binding]; other site 1138382013458 substrate binding site [chemical binding]; other site 1138382013459 putative catalytic residue [active] 1138382013460 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138382013461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382013462 S-adenosylmethionine binding site [chemical binding]; other site 1138382013463 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1138382013464 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138382013465 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1138382013466 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1138382013467 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1138382013468 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1138382013469 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138382013470 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382013471 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138382013472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382013473 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138382013474 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382013475 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382013476 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382013477 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138382013478 Pirin-related protein [General function prediction only]; Region: COG1741 1138382013479 Pirin; Region: Pirin; pfam02678 1138382013480 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1138382013481 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1138382013482 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1138382013483 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1138382013484 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138382013485 RDD family; Region: RDD; pfam06271 1138382013486 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382013487 mce related protein; Region: MCE; pfam02470 1138382013488 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382013489 mce related protein; Region: MCE; pfam02470 1138382013490 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382013491 mce related protein; Region: MCE; pfam02470 1138382013492 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382013493 mce related protein; Region: MCE; pfam02470 1138382013494 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382013495 mce related protein; Region: MCE; pfam02470 1138382013496 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138382013497 mce related protein; Region: MCE; pfam02470 1138382013498 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138382013499 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382013500 Permease; Region: Permease; pfam02405 1138382013501 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138382013502 Permease; Region: Permease; pfam02405 1138382013503 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1138382013504 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013505 acyl-activating enzyme (AAE) consensus motif; other site 1138382013506 AMP binding site [chemical binding]; other site 1138382013507 active site 1138382013508 CoA binding site [chemical binding]; other site 1138382013509 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138382013510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382013511 DNA-binding site [nucleotide binding]; DNA binding site 1138382013512 FCD domain; Region: FCD; pfam07729 1138382013513 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138382013514 putative hydrophobic ligand binding site [chemical binding]; other site 1138382013515 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138382013516 active site 1138382013517 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1138382013518 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138382013519 NAD(P) binding site [chemical binding]; other site 1138382013520 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138382013521 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138382013522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382013523 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382013524 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138382013525 classical (c) SDRs; Region: SDR_c; cd05233 1138382013526 NAD(P) binding site [chemical binding]; other site 1138382013527 active site 1138382013528 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382013529 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138382013530 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138382013531 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382013532 NAD(P) binding site [chemical binding]; other site 1138382013533 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382013534 Cytochrome P450; Region: p450; cl12078 1138382013535 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382013536 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382013537 short chain dehydrogenase; Validated; Region: PRK08264 1138382013538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013539 NAD(P) binding site [chemical binding]; other site 1138382013540 active site 1138382013541 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138382013542 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1138382013543 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382013545 active site 1138382013546 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138382013547 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138382013548 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138382013549 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138382013550 active site 1138382013551 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138382013552 catalytic triad [active] 1138382013553 dimer interface [polypeptide binding]; other site 1138382013554 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382013555 hydrophobic ligand binding site; other site 1138382013556 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1138382013557 Strictosidine synthase; Region: Str_synth; pfam03088 1138382013558 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138382013559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013561 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138382013562 FAD binding domain; Region: FAD_binding_4; pfam01565 1138382013563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013564 NAD(P) binding site [chemical binding]; other site 1138382013565 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382013566 active site 1138382013567 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138382013568 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138382013569 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138382013570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013572 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1138382013573 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1138382013574 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138382013575 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1138382013576 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138382013577 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1138382013578 ligand binding site [chemical binding]; other site 1138382013579 homodimer interface [polypeptide binding]; other site 1138382013580 NAD(P) binding site [chemical binding]; other site 1138382013581 trimer interface B [polypeptide binding]; other site 1138382013582 trimer interface A [polypeptide binding]; other site 1138382013583 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1138382013584 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382013585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013586 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1138382013587 FAD binding site [chemical binding]; other site 1138382013588 substrate binding site [chemical binding]; other site 1138382013589 catalytic base [active] 1138382013590 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1138382013591 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1138382013592 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1138382013593 short chain dehydrogenase; Provisional; Region: PRK07791 1138382013594 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138382013595 NAD binding site [chemical binding]; other site 1138382013596 homodimer interface [polypeptide binding]; other site 1138382013597 active site 1138382013598 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1138382013599 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1138382013600 NAD(P) binding site [chemical binding]; other site 1138382013601 catalytic residues [active] 1138382013602 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138382013603 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138382013604 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382013605 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382013606 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382013607 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138382013608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013610 Pirin-related protein [General function prediction only]; Region: COG1741 1138382013611 Pirin; Region: Pirin; pfam02678 1138382013612 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1138382013613 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1138382013614 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1138382013615 dimerization interface [polypeptide binding]; other site 1138382013616 DPS ferroxidase diiron center [ion binding]; other site 1138382013617 ion pore; other site 1138382013618 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138382013619 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138382013620 minor groove reading motif; other site 1138382013621 helix-hairpin-helix signature motif; other site 1138382013622 active site 1138382013623 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1138382013624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138382013625 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138382013626 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138382013627 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138382013628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013629 NAD(P) binding site [chemical binding]; other site 1138382013630 active site 1138382013631 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382013632 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1138382013633 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138382013634 Cytochrome P450; Region: p450; cl12078 1138382013635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013637 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1138382013638 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382013639 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138382013640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013642 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382013643 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138382013644 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382013645 hydrophobic ligand binding site; other site 1138382013646 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138382013647 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138382013648 putative di-iron ligands [ion binding]; other site 1138382013649 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138382013650 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138382013651 FAD binding pocket [chemical binding]; other site 1138382013652 FAD binding motif [chemical binding]; other site 1138382013653 phosphate binding motif [ion binding]; other site 1138382013654 beta-alpha-beta structure motif; other site 1138382013655 NAD binding pocket [chemical binding]; other site 1138382013656 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138382013657 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138382013658 catalytic loop [active] 1138382013659 iron binding site [ion binding]; other site 1138382013660 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1138382013661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1138382013663 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1138382013664 Coenzyme A binding pocket [chemical binding]; other site 1138382013665 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138382013666 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138382013667 Hemerythrin-like domain; Region: Hr-like; cd12108 1138382013668 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1138382013669 dimanganese center [ion binding]; other site 1138382013670 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138382013671 GAF domain; Region: GAF; pfam01590 1138382013672 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138382013673 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138382013674 putative active site [active] 1138382013675 putative catalytic site [active] 1138382013676 Domain of unknown function DUF302; Region: DUF302; pfam03625 1138382013677 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1138382013678 active site 1138382013679 metal binding site [ion binding]; metal-binding site 1138382013680 homotetramer interface [polypeptide binding]; other site 1138382013681 MarR family; Region: MarR_2; pfam12802 1138382013682 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138382013683 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265 1138382013684 Walker A/P-loop; other site 1138382013685 ATP binding site [chemical binding]; other site 1138382013686 Q-loop/lid; other site 1138382013687 ABC transporter signature motif; other site 1138382013688 Walker B; other site 1138382013689 D-loop; other site 1138382013690 H-loop/switch region; other site 1138382013691 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138382013692 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138382013693 Predicted esterase [General function prediction only]; Region: COG0627 1138382013694 Predicted membrane protein [Function unknown]; Region: COG3619 1138382013695 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1138382013696 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1138382013697 trehalose synthase; Region: treS_nterm; TIGR02456 1138382013698 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1138382013699 active site 1138382013700 catalytic site [active] 1138382013701 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138382013702 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138382013703 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1138382013704 protein binding site [polypeptide binding]; other site 1138382013705 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1138382013706 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1138382013707 elongation factor G; Reviewed; Region: PRK12740 1138382013708 G1 box; other site 1138382013709 putative GEF interaction site [polypeptide binding]; other site 1138382013710 GTP/Mg2+ binding site [chemical binding]; other site 1138382013711 Switch I region; other site 1138382013712 G2 box; other site 1138382013713 G3 box; other site 1138382013714 Switch II region; other site 1138382013715 G4 box; other site 1138382013716 G5 box; other site 1138382013717 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138382013718 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138382013719 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138382013720 acyl-CoA synthetase; Validated; Region: PRK05852 1138382013721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013722 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013723 acyl-activating enzyme (AAE) consensus motif; other site 1138382013724 acyl-activating enzyme (AAE) consensus motif; other site 1138382013725 AMP binding site [chemical binding]; other site 1138382013726 active site 1138382013727 CoA binding site [chemical binding]; other site 1138382013728 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1138382013729 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138382013730 PYR/PP interface [polypeptide binding]; other site 1138382013731 dimer interface [polypeptide binding]; other site 1138382013732 TPP binding site [chemical binding]; other site 1138382013733 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382013734 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138382013735 TPP-binding site; other site 1138382013736 dimer interface [polypeptide binding]; other site 1138382013737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138382013738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382013739 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138382013740 dimerization interface [polypeptide binding]; other site 1138382013741 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138382013742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138382013743 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138382013744 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138382013745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013747 acyl-activating enzyme (AAE) consensus motif; other site 1138382013748 acyl-activating enzyme (AAE) consensus motif; other site 1138382013749 AMP binding site [chemical binding]; other site 1138382013750 active site 1138382013751 CoA binding site [chemical binding]; other site 1138382013752 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138382013753 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138382013754 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138382013755 putative NAD(P) binding site [chemical binding]; other site 1138382013756 active site 1138382013757 putative substrate binding site [chemical binding]; other site 1138382013758 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138382013759 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138382013760 putative NAD(P) binding site [chemical binding]; other site 1138382013761 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138382013762 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138382013763 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138382013764 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382013765 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138382013766 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138382013767 active site 1138382013768 catalytic triad [active] 1138382013769 oxyanion hole [active] 1138382013770 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1138382013771 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138382013772 NAD binding site [chemical binding]; other site 1138382013773 catalytic residues [active] 1138382013774 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1138382013775 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138382013776 PYR/PP interface [polypeptide binding]; other site 1138382013777 dimer interface [polypeptide binding]; other site 1138382013778 TPP binding site [chemical binding]; other site 1138382013779 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138382013780 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138382013781 TPP-binding site; other site 1138382013782 dimer interface [polypeptide binding]; other site 1138382013783 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382013784 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382013785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013786 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382013787 NAD(P) binding site [chemical binding]; other site 1138382013788 active site 1138382013789 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382013790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382013791 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382013792 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382013793 [2Fe-2S] cluster binding site [ion binding]; other site 1138382013794 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1138382013795 putative alpha subunit interface [polypeptide binding]; other site 1138382013796 putative active site [active] 1138382013797 putative substrate binding site [chemical binding]; other site 1138382013798 Fe binding site [ion binding]; other site 1138382013799 classical (c) SDRs; Region: SDR_c; cd05233 1138382013800 NAD(P) binding site [chemical binding]; other site 1138382013801 active site 1138382013802 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1138382013803 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138382013804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138382013805 DNA-binding site [nucleotide binding]; DNA binding site 1138382013806 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1138382013807 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1138382013808 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138382013809 acyl-activating enzyme (AAE) consensus motif; other site 1138382013810 putative AMP binding site [chemical binding]; other site 1138382013811 putative active site [active] 1138382013812 putative CoA binding site [chemical binding]; other site 1138382013813 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1138382013814 classical (c) SDRs; Region: SDR_c; cd05233 1138382013815 NAD(P) binding site [chemical binding]; other site 1138382013816 active site 1138382013817 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138382013818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013819 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138382013820 acyl-activating enzyme (AAE) consensus motif; other site 1138382013821 acyl-activating enzyme (AAE) consensus motif; other site 1138382013822 putative AMP binding site [chemical binding]; other site 1138382013823 putative active site [active] 1138382013824 putative CoA binding site [chemical binding]; other site 1138382013825 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138382013826 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138382013827 NAD binding site [chemical binding]; other site 1138382013828 catalytic Zn binding site [ion binding]; other site 1138382013829 substrate binding site [chemical binding]; other site 1138382013830 structural Zn binding site [ion binding]; other site 1138382013831 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138382013832 hydrophobic ligand binding site; other site 1138382013833 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138382013834 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1138382013835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013836 NAD(P) binding site [chemical binding]; other site 1138382013837 active site 1138382013838 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138382013839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382013840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382013841 DNA binding residues [nucleotide binding] 1138382013842 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138382013843 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138382013844 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1138382013845 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1138382013846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138382013847 motif II; other site 1138382013848 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138382013849 acyl-CoA synthetase; Provisional; Region: PRK13383 1138382013850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013851 acyl-activating enzyme (AAE) consensus motif; other site 1138382013852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013853 AMP binding site [chemical binding]; other site 1138382013854 active site 1138382013855 acyl-activating enzyme (AAE) consensus motif; other site 1138382013856 CoA binding site [chemical binding]; other site 1138382013857 short chain dehydrogenase; Provisional; Region: PRK07825 1138382013858 classical (c) SDRs; Region: SDR_c; cd05233 1138382013859 NAD(P) binding site [chemical binding]; other site 1138382013860 active site 1138382013861 Cutinase; Region: Cutinase; pfam01083 1138382013862 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1138382013863 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1138382013864 putative NAD(P) binding site [chemical binding]; other site 1138382013865 active site 1138382013866 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138382013867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013869 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382013870 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138382013871 cyclase homology domain; Region: CHD; cd07302 1138382013872 nucleotidyl binding site; other site 1138382013873 metal binding site [ion binding]; metal-binding site 1138382013874 dimer interface [polypeptide binding]; other site 1138382013875 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382013876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382013877 S-adenosylmethionine binding site [chemical binding]; other site 1138382013878 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138382013879 hydrophobic ligand binding site; other site 1138382013880 short chain dehydrogenase; Validated; Region: PRK08264 1138382013881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013882 NAD(P) binding site [chemical binding]; other site 1138382013883 active site 1138382013884 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1138382013885 CGNR zinc finger; Region: zf-CGNR; pfam11706 1138382013886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138382013887 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138382013888 S-adenosylmethionine binding site [chemical binding]; other site 1138382013889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013890 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138382013891 NAD(P) binding site [chemical binding]; other site 1138382013892 active site 1138382013893 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138382013894 CoenzymeA binding site [chemical binding]; other site 1138382013895 subunit interaction site [polypeptide binding]; other site 1138382013896 PHB binding site; other site 1138382013897 Predicted membrane protein [Function unknown]; Region: COG3305 1138382013898 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1138382013899 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1138382013900 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138382013901 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138382013902 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1138382013903 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138382013904 putative NAD(P) binding site [chemical binding]; other site 1138382013905 catalytic Zn binding site [ion binding]; other site 1138382013906 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138382013907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013908 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138382013909 NAD(P) binding site [chemical binding]; other site 1138382013910 active site 1138382013911 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1138382013912 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1138382013913 short chain dehydrogenase; Provisional; Region: PRK06940 1138382013914 classical (c) SDRs; Region: SDR_c; cd05233 1138382013915 NAD(P) binding site [chemical binding]; other site 1138382013916 active site 1138382013917 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138382013918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138382013919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382013920 Protein of unknown function, DUF417; Region: DUF417; cl01162 1138382013921 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138382013922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013923 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138382013924 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138382013925 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1138382013926 putative hydrophobic ligand binding site [chemical binding]; other site 1138382013927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138382013928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138382013929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1138382013930 dimerization interface [polypeptide binding]; other site 1138382013931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138382013932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138382013933 NAD(P) binding site [chemical binding]; other site 1138382013934 active site 1138382013935 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138382013936 classical (c) SDRs; Region: SDR_c; cd05233 1138382013937 NAD(P) binding site [chemical binding]; other site 1138382013938 active site 1138382013939 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138382013940 classical (c) SDRs; Region: SDR_c; cd05233 1138382013941 NAD(P) binding site [chemical binding]; other site 1138382013942 active site 1138382013943 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138382013944 metal-binding site [ion binding] 1138382013945 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138382013946 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138382013947 metal-binding site [ion binding] 1138382013948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138382013949 Predicted esterase [General function prediction only]; Region: COG0627 1138382013950 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1138382013951 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1138382013952 NodB motif; other site 1138382013953 active site 1138382013954 catalytic site [active] 1138382013955 metal binding site [ion binding]; metal-binding site 1138382013956 Secretory lipase; Region: LIP; pfam03583 1138382013957 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138382013958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138382013959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013961 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138382013962 classical (c) SDRs; Region: SDR_c; cd05233 1138382013963 NAD(P) binding site [chemical binding]; other site 1138382013964 active site 1138382013965 acyl-CoA synthetase; Provisional; Region: PRK13388 1138382013966 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138382013967 acyl-activating enzyme (AAE) consensus motif; other site 1138382013968 AMP binding site [chemical binding]; other site 1138382013969 active site 1138382013970 CoA binding site [chemical binding]; other site 1138382013971 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382013972 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382013973 active site 1138382013974 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382013975 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382013976 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138382013977 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138382013978 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138382013979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1138382013980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1138382013981 DNA binding site [nucleotide binding] 1138382013982 domain linker motif; other site 1138382013983 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1138382013984 dimerization interface [polypeptide binding]; other site 1138382013985 ligand binding site [chemical binding]; other site 1138382013986 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138382013987 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138382013988 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1138382013989 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138382013990 active site 1138382013991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013992 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138382013993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382013994 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138382013995 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138382013996 active site 1138382013997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382013998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382013999 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138382014000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382014001 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1138382014002 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1138382014003 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138382014004 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138382014005 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1138382014006 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 1138382014007 putative active site [active] 1138382014008 catalytic residue [active] 1138382014009 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138382014010 anti sigma factor interaction site; other site 1138382014011 regulatory phosphorylation site [posttranslational modification]; other site 1138382014012 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138382014013 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138382014014 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138382014015 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382014016 putative active site [active] 1138382014017 ATP binding site [chemical binding]; other site 1138382014018 putative substrate binding site [chemical binding]; other site 1138382014019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138382014020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138382014021 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1138382014022 Ecdysteroid kinase; Region: EcKinase; cl17738 1138382014023 Phosphotransferase enzyme family; Region: APH; pfam01636 1138382014024 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138382014025 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1138382014026 active site 1138382014027 putative substrate binding pocket [chemical binding]; other site 1138382014028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138382014029 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138382014030 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138382014031 [2Fe-2S] cluster binding site [ion binding]; other site 1138382014032 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1138382014033 putative alpha subunit interface [polypeptide binding]; other site 1138382014034 putative active site [active] 1138382014035 putative substrate binding site [chemical binding]; other site 1138382014036 Fe binding site [ion binding]; other site 1138382014037 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138382014038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138382014039 active site 1138382014040 phosphorylation site [posttranslational modification] 1138382014041 intermolecular recognition site; other site 1138382014042 dimerization interface [polypeptide binding]; other site 1138382014043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138382014044 DNA binding residues [nucleotide binding] 1138382014045 dimerization interface [polypeptide binding]; other site 1138382014046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138382014047 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138382014048 Transport protein; Region: actII; TIGR00833 1138382014049 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138382014050 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382014051 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138382014052 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382014053 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138382014054 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138382014055 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1138382014056 catalytic residue [active] 1138382014057 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1138382014058 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138382014059 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1138382014060 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1138382014061 active site 1138382014062 NTP binding site [chemical binding]; other site 1138382014063 metal binding triad [ion binding]; metal-binding site 1138382014064 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1138382014065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138382014066 Zn2+ binding site [ion binding]; other site 1138382014067 Mg2+ binding site [ion binding]; other site 1138382014068 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1138382014069 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138382014070 active site 1138382014071 Ap6A binding site [chemical binding]; other site 1138382014072 nudix motif; other site 1138382014073 metal binding site [ion binding]; metal-binding site 1138382014074 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1138382014075 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1138382014076 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1138382014077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138382014078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138382014079 DNA binding residues [nucleotide binding] 1138382014080 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138382014081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138382014082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138382014083 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138382014084 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1138382014085 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138382014086 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138382014087 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138382014088 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138382014089 active site 1138382014090 metal binding site [ion binding]; metal-binding site 1138382014091 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1138382014092 ParB-like nuclease domain; Region: ParBc; pfam02195 1138382014093 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138382014094 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138382014095 P-loop; other site 1138382014096 Magnesium ion binding site [ion binding]; other site 1138382014097 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138382014098 Magnesium ion binding site [ion binding]; other site 1138382014099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138382014100 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1138382014101 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1138382014102 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1138382014103 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1138382014104 G-X-X-G motif; other site 1138382014105 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1138382014106 RxxxH motif; other site 1138382014107 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1138382014108 Ribonuclease P; Region: Ribonuclease_P; cl00457