-- dump date 20140619_152523 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1138383000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1138383000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383000003 Walker A motif; other site 1138383000004 ATP binding site [chemical binding]; other site 1138383000005 Walker B motif; other site 1138383000006 arginine finger; other site 1138383000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1138383000008 DnaA box-binding interface [nucleotide binding]; other site 1138383000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1138383000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1138383000011 putative DNA binding surface [nucleotide binding]; other site 1138383000012 dimer interface [polypeptide binding]; other site 1138383000013 beta-clamp/clamp loader binding surface; other site 1138383000014 beta-clamp/translesion DNA polymerase binding surface; other site 1138383000015 recombination protein F; Reviewed; Region: recF; PRK00064 1138383000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1138383000017 Walker A/P-loop; other site 1138383000018 ATP binding site [chemical binding]; other site 1138383000019 Q-loop/lid; other site 1138383000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383000021 ABC transporter signature motif; other site 1138383000022 Walker B; other site 1138383000023 D-loop; other site 1138383000024 H-loop/switch region; other site 1138383000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1138383000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1138383000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383000028 Mg2+ binding site [ion binding]; other site 1138383000029 G-X-G motif; other site 1138383000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1138383000031 anchoring element; other site 1138383000032 dimer interface [polypeptide binding]; other site 1138383000033 ATP binding site [chemical binding]; other site 1138383000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1138383000035 active site 1138383000036 putative metal-binding site [ion binding]; other site 1138383000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1138383000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1138383000039 CAP-like domain; other site 1138383000040 active site 1138383000041 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138383000042 protein-splicing catalytic site; other site 1138383000043 thioester formation/cholesterol transfer; other site 1138383000044 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1138383000045 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1138383000046 DNA gyrase subunit A; Validated; Region: PRK05560 1138383000047 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1138383000048 primary dimer interface [polypeptide binding]; other site 1138383000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138383000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138383000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138383000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138383000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138383000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138383000055 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1138383000056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383000059 Cytochrome P450; Region: p450; cl12078 1138383000060 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1138383000061 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138383000062 active site 1138383000063 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138383000064 putative septation inhibitor protein; Reviewed; Region: PRK00159 1138383000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138383000066 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138383000067 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1138383000068 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1138383000069 glutamine binding [chemical binding]; other site 1138383000070 catalytic triad [active] 1138383000071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138383000072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383000073 active site 1138383000074 ATP binding site [chemical binding]; other site 1138383000075 substrate binding site [chemical binding]; other site 1138383000076 activation loop (A-loop); other site 1138383000077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1138383000078 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138383000079 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138383000080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138383000081 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138383000082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383000083 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383000084 active site 1138383000085 ATP binding site [chemical binding]; other site 1138383000086 substrate binding site [chemical binding]; other site 1138383000087 activation loop (A-loop); other site 1138383000088 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138383000089 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138383000090 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1138383000091 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1138383000092 active site 1138383000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383000094 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383000095 phosphopeptide binding site; other site 1138383000096 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1138383000097 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383000098 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383000099 phosphopeptide binding site; other site 1138383000100 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383000101 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138383000102 DinB superfamily; Region: DinB_2; pfam12867 1138383000103 acyl carrier protein; Validated; Region: PRK05883 1138383000104 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1138383000105 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383000106 acyl-activating enzyme (AAE) consensus motif; other site 1138383000107 AMP binding site [chemical binding]; other site 1138383000108 active site 1138383000109 CoA binding site [chemical binding]; other site 1138383000110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138383000111 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138383000112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383000113 Coenzyme A binding pocket [chemical binding]; other site 1138383000114 Pirin-related protein [General function prediction only]; Region: COG1741 1138383000115 Pirin; Region: Pirin; pfam02678 1138383000116 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1138383000117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383000118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383000119 active site 1138383000120 Transcription factor WhiB; Region: Whib; pfam02467 1138383000121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383000122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383000123 non-specific DNA binding site [nucleotide binding]; other site 1138383000124 salt bridge; other site 1138383000125 sequence-specific DNA binding site [nucleotide binding]; other site 1138383000126 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138383000127 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138383000128 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138383000129 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138383000130 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1138383000131 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1138383000132 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1138383000133 TIGR03084 family protein; Region: TIGR03084 1138383000134 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383000135 Wyosine base formation; Region: Wyosine_form; pfam08608 1138383000136 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138383000137 hypothetical protein; Validated; Region: PRK00228 1138383000138 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138383000139 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1138383000140 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383000141 active site 1138383000142 HIGH motif; other site 1138383000143 nucleotide binding site [chemical binding]; other site 1138383000144 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138383000145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383000146 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383000147 active site 1138383000148 KMSKS motif; other site 1138383000149 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1138383000150 tRNA binding surface [nucleotide binding]; other site 1138383000151 anticodon binding site; other site 1138383000152 short chain dehydrogenase; Provisional; Region: PRK08219 1138383000153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383000154 NAD(P) binding site [chemical binding]; other site 1138383000155 active site 1138383000156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383000157 MarR family; Region: MarR; pfam01047 1138383000158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383000159 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1138383000160 Walker A/P-loop; other site 1138383000161 ATP binding site [chemical binding]; other site 1138383000162 Q-loop/lid; other site 1138383000163 ABC transporter signature motif; other site 1138383000164 Walker B; other site 1138383000165 D-loop; other site 1138383000166 H-loop/switch region; other site 1138383000167 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138383000168 substrate binding pocket [chemical binding]; other site 1138383000169 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1138383000170 membrane-bound complex binding site; other site 1138383000171 hinge residues; other site 1138383000172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383000173 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1138383000174 dimer interface [polypeptide binding]; other site 1138383000175 conserved gate region; other site 1138383000176 putative PBP binding loops; other site 1138383000177 ABC-ATPase subunit interface; other site 1138383000178 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138383000179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383000180 DNA-binding site [nucleotide binding]; DNA binding site 1138383000181 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1138383000182 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383000183 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383000184 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138383000185 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138383000186 active site 1138383000187 FMN binding site [chemical binding]; other site 1138383000188 substrate binding site [chemical binding]; other site 1138383000189 putative catalytic residue [active] 1138383000190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383000191 NAD(P) binding site [chemical binding]; other site 1138383000192 active site 1138383000193 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383000194 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138383000195 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1138383000196 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383000197 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383000198 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1138383000199 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1138383000200 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138383000201 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138383000202 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138383000203 Transglycosylase; Region: Transgly; pfam00912 1138383000204 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1138383000205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138383000206 Predicted integral membrane protein [Function unknown]; Region: COG5650 1138383000207 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138383000208 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138383000209 conserved cys residue [active] 1138383000210 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1138383000211 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138383000212 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138383000213 dimer interface [polypeptide binding]; other site 1138383000214 ssDNA binding site [nucleotide binding]; other site 1138383000215 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138383000216 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1138383000217 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1138383000218 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1138383000219 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1138383000220 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1138383000221 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138383000222 Walker A motif; other site 1138383000223 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1138383000224 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1138383000225 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1138383000226 ATP binding site [chemical binding]; other site 1138383000227 Walker B motif; other site 1138383000228 DNA binding loops [nucleotide binding] 1138383000229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000231 Transport protein; Region: actII; TIGR00833 1138383000232 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383000233 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138383000234 DNA-binding site [nucleotide binding]; DNA binding site 1138383000235 RNA-binding motif; other site 1138383000236 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383000237 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383000238 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138383000239 classical (c) SDRs; Region: SDR_c; cd05233 1138383000240 NAD(P) binding site [chemical binding]; other site 1138383000241 active site 1138383000242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383000243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383000244 NAD(P) binding site [chemical binding]; other site 1138383000245 active site 1138383000246 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383000247 Cytochrome P450; Region: p450; cl12078 1138383000248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383000249 short chain dehydrogenase; Provisional; Region: PRK08303 1138383000250 NAD(P) binding site [chemical binding]; other site 1138383000251 active site 1138383000252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000254 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138383000255 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138383000256 putative dimer interface [polypeptide binding]; other site 1138383000257 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383000258 classical (c) SDRs; Region: SDR_c; cd05233 1138383000259 NAD(P) binding site [chemical binding]; other site 1138383000260 active site 1138383000261 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138383000262 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383000263 Berberine and berberine like; Region: BBE; pfam08031 1138383000264 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138383000265 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138383000266 ligand binding site [chemical binding]; other site 1138383000267 flexible hinge region; other site 1138383000268 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138383000269 putative switch regulator; other site 1138383000270 non-specific DNA interactions [nucleotide binding]; other site 1138383000271 DNA binding site [nucleotide binding] 1138383000272 sequence specific DNA binding site [nucleotide binding]; other site 1138383000273 putative cAMP binding site [chemical binding]; other site 1138383000274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383000275 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383000276 PGAP1-like protein; Region: PGAP1; pfam07819 1138383000277 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138383000278 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1138383000279 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1138383000280 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138383000281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383000282 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1138383000283 active site 1138383000284 Permease; Region: Permease; pfam02405 1138383000285 Permease; Region: Permease; pfam02405 1138383000286 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383000287 mce related protein; Region: MCE; pfam02470 1138383000288 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383000289 mce related protein; Region: MCE; pfam02470 1138383000290 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383000291 mce related protein; Region: MCE; pfam02470 1138383000292 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383000293 mce related protein; Region: MCE; pfam02470 1138383000294 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383000295 mce related protein; Region: MCE; pfam02470 1138383000296 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138383000297 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383000298 mce related protein; Region: MCE; pfam02470 1138383000299 Mannan-binding protein; Region: MVL; pfam12151 1138383000300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000304 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1138383000305 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138383000306 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383000307 PPE family; Region: PPE; pfam00823 1138383000308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383000309 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383000310 S-adenosylmethionine binding site [chemical binding]; other site 1138383000311 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383000312 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383000313 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383000314 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138383000315 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1138383000316 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138383000317 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383000318 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383000319 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1138383000320 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1138383000321 putative ligand binding site [chemical binding]; other site 1138383000322 NAD binding site [chemical binding]; other site 1138383000323 catalytic site [active] 1138383000324 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138383000325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138383000326 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383000327 Cytochrome P450; Region: p450; cl12078 1138383000328 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138383000329 metal ion-dependent adhesion site (MIDAS); other site 1138383000330 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138383000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383000332 Walker A motif; other site 1138383000333 ATP binding site [chemical binding]; other site 1138383000334 Walker B motif; other site 1138383000335 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138383000336 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1138383000337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000338 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383000339 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383000340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383000341 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138383000342 putative substrate translocation pore; other site 1138383000343 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383000344 Fe binding site [ion binding]; other site 1138383000345 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383000346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383000347 S-adenosylmethionine binding site [chemical binding]; other site 1138383000348 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383000349 active site 1138383000350 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1138383000351 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1138383000352 putative active site [active] 1138383000353 putative CoA binding site [chemical binding]; other site 1138383000354 nudix motif; other site 1138383000355 metal binding site [ion binding]; metal-binding site 1138383000356 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1138383000357 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1138383000358 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383000359 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383000360 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138383000361 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138383000362 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1138383000363 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383000364 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138383000365 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383000366 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138383000367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383000368 hypothetical protein; Provisional; Region: PRK01346 1138383000369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383000370 Coenzyme A binding pocket [chemical binding]; other site 1138383000371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383000372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383000373 active site 1138383000374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383000377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383000378 dimer interface [polypeptide binding]; other site 1138383000379 phosphorylation site [posttranslational modification] 1138383000380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383000381 ATP binding site [chemical binding]; other site 1138383000382 Mg2+ binding site [ion binding]; other site 1138383000383 G-X-G motif; other site 1138383000384 PPE family; Region: PPE; pfam00823 1138383000385 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138383000386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138383000387 EspG family; Region: ESX-1_EspG; pfam14011 1138383000388 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138383000389 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138383000390 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138383000391 catalytic residues [active] 1138383000392 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138383000393 catalytic residues [active] 1138383000394 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138383000395 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138383000396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383000397 Walker A motif; other site 1138383000398 ATP binding site [chemical binding]; other site 1138383000399 Walker B motif; other site 1138383000400 arginine finger; other site 1138383000401 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138383000402 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138383000403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383000404 NAD(P) binding site [chemical binding]; other site 1138383000405 active site 1138383000406 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1138383000407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383000408 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138383000409 DNA binding residues [nucleotide binding] 1138383000410 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138383000411 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1138383000412 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1138383000413 active site 1138383000414 dimer interface [polypeptide binding]; other site 1138383000415 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1138383000416 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1138383000417 active site 1138383000418 FMN binding site [chemical binding]; other site 1138383000419 substrate binding site [chemical binding]; other site 1138383000420 3Fe-4S cluster binding site [ion binding]; other site 1138383000421 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1138383000422 domain interface; other site 1138383000423 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1138383000424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383000425 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138383000426 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383000427 hypothetical protein; Provisional; Region: PRK07945 1138383000428 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1138383000429 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1138383000430 active site 1138383000431 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1138383000432 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138383000433 DNA polymerase IV; Validated; Region: PRK03858 1138383000434 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138383000435 active site 1138383000436 DNA binding site [nucleotide binding] 1138383000437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000439 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383000440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383000441 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1138383000442 CopC domain; Region: CopC; pfam04234 1138383000443 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1138383000444 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1138383000445 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1138383000446 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1138383000447 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1138383000448 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1138383000449 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138383000450 putative active site [active] 1138383000451 catalytic site [active] 1138383000452 putative metal binding site [ion binding]; other site 1138383000453 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1138383000454 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1138383000455 prephenate dehydratase; Provisional; Region: PRK11898 1138383000456 Prephenate dehydratase; Region: PDT; pfam00800 1138383000457 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1138383000458 putative L-Phe binding site [chemical binding]; other site 1138383000459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383000460 catalytic core [active] 1138383000461 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1138383000462 Septum formation; Region: Septum_form; pfam13845 1138383000463 Septum formation; Region: Septum_form; pfam13845 1138383000464 seryl-tRNA synthetase; Provisional; Region: PRK05431 1138383000465 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1138383000466 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1138383000467 dimer interface [polypeptide binding]; other site 1138383000468 active site 1138383000469 motif 1; other site 1138383000470 motif 2; other site 1138383000471 motif 3; other site 1138383000472 Cupin domain; Region: Cupin_2; cl17218 1138383000473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383000474 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138383000475 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383000476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383000477 S-adenosylmethionine binding site [chemical binding]; other site 1138383000478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383000479 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1138383000480 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383000481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000482 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138383000483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383000484 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1138383000485 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138383000486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138383000487 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138383000488 iron-sulfur cluster [ion binding]; other site 1138383000489 [2Fe-2S] cluster binding site [ion binding]; other site 1138383000490 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383000491 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138383000492 putative acyl-acceptor binding pocket; other site 1138383000493 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383000494 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138383000495 putative acyl-acceptor binding pocket; other site 1138383000496 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383000497 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138383000498 putative acyl-acceptor binding pocket; other site 1138383000499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383000500 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1138383000501 active site 1138383000502 motif I; other site 1138383000503 motif II; other site 1138383000504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383000505 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138383000506 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1138383000507 amidase catalytic site [active] 1138383000508 Zn binding residues [ion binding]; other site 1138383000509 substrate binding site [chemical binding]; other site 1138383000510 LGFP repeat; Region: LGFP; pfam08310 1138383000511 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1138383000512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383000513 UDP-galactopyranose mutase; Region: GLF; pfam03275 1138383000514 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138383000515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138383000516 active site 1138383000517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138383000518 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1138383000519 Predicted esterase [General function prediction only]; Region: COG0627 1138383000520 Putative esterase; Region: Esterase; pfam00756 1138383000521 Cutinase; Region: Cutinase; pfam01083 1138383000522 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1138383000523 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138383000524 acyl-activating enzyme (AAE) consensus motif; other site 1138383000525 active site 1138383000526 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383000527 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383000528 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138383000529 active site 1138383000530 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138383000531 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383000532 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383000533 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1138383000534 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138383000535 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138383000536 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383000537 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138383000538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383000539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383000540 DNA binding residues [nucleotide binding] 1138383000541 RibD C-terminal domain; Region: RibD_C; cl17279 1138383000542 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383000543 active site 1138383000544 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383000545 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138383000546 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1138383000547 ligand binding site [chemical binding]; other site 1138383000548 flexible hinge region; other site 1138383000549 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138383000550 putative switch regulator; other site 1138383000551 non-specific DNA interactions [nucleotide binding]; other site 1138383000552 DNA binding site [nucleotide binding] 1138383000553 sequence specific DNA binding site [nucleotide binding]; other site 1138383000554 putative cAMP binding site [chemical binding]; other site 1138383000555 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383000556 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383000557 phosphopeptide binding site; other site 1138383000558 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138383000559 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138383000560 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383000561 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383000562 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1138383000563 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1138383000564 putative hydrophobic ligand binding site [chemical binding]; other site 1138383000565 CLM binding site; other site 1138383000566 L1 loop; other site 1138383000567 DNA binding site [nucleotide binding] 1138383000568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383000569 putative DNA binding site [nucleotide binding]; other site 1138383000570 putative Zn2+ binding site [ion binding]; other site 1138383000571 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138383000572 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1138383000573 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1138383000574 short chain dehydrogenase; Provisional; Region: PRK07904 1138383000575 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138383000576 NAD(P) binding site [chemical binding]; other site 1138383000577 active site 1138383000578 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138383000579 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383000580 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1138383000581 Predicted membrane protein [Function unknown]; Region: COG2246 1138383000582 GtrA-like protein; Region: GtrA; pfam04138 1138383000583 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1138383000584 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138383000585 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383000586 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383000587 active site 1138383000588 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1138383000589 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138383000590 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138383000591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138383000592 active site 1138383000593 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1138383000594 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1138383000595 Walker A/P-loop; other site 1138383000596 ATP binding site [chemical binding]; other site 1138383000597 Q-loop/lid; other site 1138383000598 ABC transporter signature motif; other site 1138383000599 Walker B; other site 1138383000600 D-loop; other site 1138383000601 H-loop/switch region; other site 1138383000602 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1138383000603 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138383000604 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383000605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383000606 catalytic residue [active] 1138383000607 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1138383000608 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1138383000609 NAD(P) binding site [chemical binding]; other site 1138383000610 eRF1 domain 3; Region: eRF1_3; pfam03465 1138383000611 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383000612 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383000613 enoyl-CoA hydratase; Provisional; Region: PRK06142 1138383000614 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383000615 substrate binding site [chemical binding]; other site 1138383000616 oxyanion hole (OAH) forming residues; other site 1138383000617 trimer interface [polypeptide binding]; other site 1138383000618 TIGR03086 family protein; Region: TIGR03086 1138383000619 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383000620 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138383000621 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138383000622 Integrase core domain; Region: rve; pfam00665 1138383000623 GXWXG protein; Region: GXWXG; pfam14231 1138383000624 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1138383000625 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1138383000626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383000627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383000628 homodimer interface [polypeptide binding]; other site 1138383000629 catalytic residue [active] 1138383000630 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383000631 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383000632 putative active site [active] 1138383000633 putative substrate binding site [chemical binding]; other site 1138383000634 ATP binding site [chemical binding]; other site 1138383000635 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383000636 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383000637 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383000638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383000639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383000640 active site 1138383000641 phosphorylation site [posttranslational modification] 1138383000642 intermolecular recognition site; other site 1138383000643 dimerization interface [polypeptide binding]; other site 1138383000644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383000645 DNA binding site [nucleotide binding] 1138383000646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383000647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1138383000648 dimerization interface [polypeptide binding]; other site 1138383000649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383000650 dimer interface [polypeptide binding]; other site 1138383000651 phosphorylation site [posttranslational modification] 1138383000652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383000653 ATP binding site [chemical binding]; other site 1138383000654 Mg2+ binding site [ion binding]; other site 1138383000655 G-X-G motif; other site 1138383000656 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138383000657 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1138383000658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383000659 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138383000660 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138383000661 NAD(P) binding site [chemical binding]; other site 1138383000662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383000665 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383000666 active site 1138383000667 short chain dehydrogenase; Provisional; Region: PRK07035 1138383000668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383000669 NAD(P) binding site [chemical binding]; other site 1138383000670 active site 1138383000671 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383000672 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383000673 putative active site [active] 1138383000674 putative substrate binding site [chemical binding]; other site 1138383000675 ATP binding site [chemical binding]; other site 1138383000676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383000677 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383000678 catalytic core [active] 1138383000679 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383000680 putative active site [active] 1138383000681 putative substrate binding site [chemical binding]; other site 1138383000682 ATP binding site [chemical binding]; other site 1138383000683 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1138383000684 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1138383000685 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1138383000686 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1138383000687 Walker A/P-loop; other site 1138383000688 ATP binding site [chemical binding]; other site 1138383000689 Q-loop/lid; other site 1138383000690 ABC transporter signature motif; other site 1138383000691 Walker B; other site 1138383000692 D-loop; other site 1138383000693 H-loop/switch region; other site 1138383000694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1138383000695 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1138383000696 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1138383000697 prephenate dehydrogenase; Validated; Region: PRK06545 1138383000698 prephenate dehydrogenase; Validated; Region: PRK08507 1138383000699 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1138383000700 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138383000701 nucleoside/Zn binding site; other site 1138383000702 dimer interface [polypeptide binding]; other site 1138383000703 catalytic motif [active] 1138383000704 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1138383000705 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1138383000706 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138383000707 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1138383000708 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1138383000709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383000710 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383000711 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383000712 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138383000713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383000714 DNA-binding site [nucleotide binding]; DNA binding site 1138383000715 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138383000716 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138383000717 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138383000718 active site 1138383000719 non-prolyl cis peptide bond; other site 1138383000720 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383000721 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383000722 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138383000723 pyruvate carboxylase; Reviewed; Region: PRK12999 1138383000724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138383000725 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383000726 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138383000727 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1138383000728 active site 1138383000729 catalytic residues [active] 1138383000730 metal binding site [ion binding]; metal-binding site 1138383000731 homodimer binding site [polypeptide binding]; other site 1138383000732 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138383000733 carboxyltransferase (CT) interaction site; other site 1138383000734 biotinylation site [posttranslational modification]; other site 1138383000735 citrate synthase; Provisional; Region: PRK14033 1138383000736 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1138383000737 dimer interface [polypeptide binding]; other site 1138383000738 active site 1138383000739 citrylCoA binding site [chemical binding]; other site 1138383000740 oxalacetate/citrate binding site [chemical binding]; other site 1138383000741 coenzyme A binding site [chemical binding]; other site 1138383000742 catalytic triad [active] 1138383000743 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1138383000744 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138383000745 tetramer interface [polypeptide binding]; other site 1138383000746 active site 1138383000747 Mg2+/Mn2+ binding site [ion binding]; other site 1138383000748 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1138383000749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383000750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383000751 sequence-specific DNA binding site [nucleotide binding]; other site 1138383000752 salt bridge; other site 1138383000753 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1138383000754 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138383000755 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138383000756 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1138383000757 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138383000758 substrate binding site [chemical binding]; other site 1138383000759 ATP binding site [chemical binding]; other site 1138383000760 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1138383000761 dimerization interface [polypeptide binding]; other site 1138383000762 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1138383000763 NAD binding site [chemical binding]; other site 1138383000764 ligand binding site [chemical binding]; other site 1138383000765 catalytic site [active] 1138383000766 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383000767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000768 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383000769 classical (c) SDRs; Region: SDR_c; cd05233 1138383000770 NAD(P) binding site [chemical binding]; other site 1138383000771 active site 1138383000772 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383000773 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383000774 active site 1138383000775 metal binding site [ion binding]; metal-binding site 1138383000776 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383000777 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383000778 short chain dehydrogenase; Provisional; Region: PRK07856 1138383000779 classical (c) SDRs; Region: SDR_c; cd05233 1138383000780 NAD(P) binding site [chemical binding]; other site 1138383000781 active site 1138383000782 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383000783 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383000784 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 1138383000785 nudix motif; other site 1138383000786 haloalkane dehalogenase; Provisional; Region: PRK00870 1138383000787 Cytochrome P450; Region: p450; cl12078 1138383000788 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383000789 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383000790 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383000791 active site 1138383000792 Transposase; Region: HTH_Tnp_1; cl17663 1138383000793 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383000794 putative transposase OrfB; Reviewed; Region: PHA02517 1138383000795 HTH-like domain; Region: HTH_21; pfam13276 1138383000796 Integrase core domain; Region: rve; pfam00665 1138383000797 Integrase core domain; Region: rve_3; pfam13683 1138383000798 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1138383000799 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1138383000800 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1138383000801 active site 1138383000802 DNA binding site [nucleotide binding] 1138383000803 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1138383000804 DNA binding site [nucleotide binding] 1138383000805 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138383000806 nucleotide binding site [chemical binding]; other site 1138383000807 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1138383000808 Isochorismatase family; Region: Isochorismatase; pfam00857 1138383000809 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138383000810 catalytic triad [active] 1138383000811 conserved cis-peptide bond; other site 1138383000812 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383000813 Cytochrome P450; Region: p450; cl12078 1138383000814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383000815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383000816 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138383000817 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138383000818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383000819 NAD(P) binding site [chemical binding]; other site 1138383000820 active site 1138383000821 Cutinase; Region: Cutinase; pfam01083 1138383000822 CsbD-like; Region: CsbD; pfam05532 1138383000823 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383000824 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383000825 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383000826 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383000827 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1138383000828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383000829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383000830 catalytic residue [active] 1138383000831 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1138383000832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383000833 Walker A motif; other site 1138383000834 ATP binding site [chemical binding]; other site 1138383000835 Walker B motif; other site 1138383000836 arginine finger; other site 1138383000837 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1138383000838 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383000839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383000840 S-adenosylmethionine binding site [chemical binding]; other site 1138383000841 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138383000842 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383000843 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138383000844 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138383000845 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138383000846 active site 1138383000847 metal binding site [ion binding]; metal-binding site 1138383000848 hypothetical protein; Validated; Region: PRK00153 1138383000849 recombination protein RecR; Reviewed; Region: recR; PRK00076 1138383000850 RecR protein; Region: RecR; pfam02132 1138383000851 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1138383000852 putative active site [active] 1138383000853 putative metal-binding site [ion binding]; other site 1138383000854 tetramer interface [polypeptide binding]; other site 1138383000855 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138383000856 catalytic triad [active] 1138383000857 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1138383000858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138383000859 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1138383000860 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1138383000861 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138383000862 active site 1138383000863 catalytic site [active] 1138383000864 substrate binding site [chemical binding]; other site 1138383000865 2-isopropylmalate synthase; Validated; Region: PRK03739 1138383000866 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1138383000867 active site 1138383000868 catalytic residues [active] 1138383000869 metal binding site [ion binding]; metal-binding site 1138383000870 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1138383000871 aspartate kinase; Reviewed; Region: PRK06635 1138383000872 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1138383000873 putative nucleotide binding site [chemical binding]; other site 1138383000874 putative catalytic residues [active] 1138383000875 putative Mg ion binding site [ion binding]; other site 1138383000876 putative aspartate binding site [chemical binding]; other site 1138383000877 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1138383000878 putative allosteric regulatory site; other site 1138383000879 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1138383000880 putative allosteric regulatory residue; other site 1138383000881 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1138383000882 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138383000883 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138383000884 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383000885 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 1138383000886 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1138383000887 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138383000888 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1138383000889 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138383000890 putative active site [active] 1138383000891 putative dimer interface [polypeptide binding]; other site 1138383000892 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1138383000893 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1138383000894 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383000895 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138383000896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383000897 catalytic residue [active] 1138383000898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383000899 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383000900 S-adenosylmethionine binding site [chemical binding]; other site 1138383000901 glycerol kinase; Provisional; Region: glpK; PRK00047 1138383000902 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1138383000903 N- and C-terminal domain interface [polypeptide binding]; other site 1138383000904 active site 1138383000905 MgATP binding site [chemical binding]; other site 1138383000906 catalytic site [active] 1138383000907 metal binding site [ion binding]; metal-binding site 1138383000908 putative homotetramer interface [polypeptide binding]; other site 1138383000909 glycerol binding site [chemical binding]; other site 1138383000910 homodimer interface [polypeptide binding]; other site 1138383000911 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138383000912 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138383000913 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1138383000914 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1138383000915 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138383000916 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138383000917 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138383000918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383000919 Walker A motif; other site 1138383000920 ATP binding site [chemical binding]; other site 1138383000921 Walker B motif; other site 1138383000922 arginine finger; other site 1138383000923 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138383000924 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1138383000925 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138383000926 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383000927 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1138383000928 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1138383000929 proposed catalytic triad [active] 1138383000930 conserved cys residue [active] 1138383000931 putative methyltransferase; Provisional; Region: PRK14967 1138383000932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383000933 S-adenosylmethionine binding site [chemical binding]; other site 1138383000934 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1138383000935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138383000936 PAS domain; Region: PAS_9; pfam13426 1138383000937 putative active site [active] 1138383000938 heme pocket [chemical binding]; other site 1138383000939 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138383000940 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138383000941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138383000942 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1138383000943 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138383000944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383000945 ATP binding site [chemical binding]; other site 1138383000946 Mg2+ binding site [ion binding]; other site 1138383000947 G-X-G motif; other site 1138383000948 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1138383000949 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1138383000950 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1138383000951 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383000952 anti sigma factor interaction site; other site 1138383000953 regulatory phosphorylation site [posttranslational modification]; other site 1138383000954 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1138383000955 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1138383000956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383000957 motif II; other site 1138383000958 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1138383000959 Restriction endonuclease; Region: Mrr_cat; pfam04471 1138383000960 GAF domain; Region: GAF; cl17456 1138383000961 GAF domain; Region: GAF_2; pfam13185 1138383000962 ANTAR domain; Region: ANTAR; pfam03861 1138383000963 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138383000964 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1138383000965 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383000966 catalytic residue [active] 1138383000967 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1138383000968 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1138383000969 putative active site [active] 1138383000970 putative metal binding site [ion binding]; other site 1138383000971 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1138383000972 Transglycosylase; Region: Transgly; pfam00912 1138383000973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1138383000974 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138383000975 Transcription factor WhiB; Region: Whib; pfam02467 1138383000976 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138383000977 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138383000978 DTAP/Switch II; other site 1138383000979 Switch I; other site 1138383000980 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138383000981 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138383000982 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138383000983 P loop; other site 1138383000984 Nucleotide binding site [chemical binding]; other site 1138383000985 DTAP/Switch II; other site 1138383000986 Switch I; other site 1138383000987 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1138383000988 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1138383000989 homotrimer interaction site [polypeptide binding]; other site 1138383000990 putative active site [active] 1138383000991 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383000992 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138383000993 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138383000994 ligand binding site [chemical binding]; other site 1138383000995 flexible hinge region; other site 1138383000996 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138383000997 putative switch regulator; other site 1138383000998 non-specific DNA interactions [nucleotide binding]; other site 1138383000999 DNA binding site [nucleotide binding] 1138383001000 sequence specific DNA binding site [nucleotide binding]; other site 1138383001001 putative cAMP binding site [chemical binding]; other site 1138383001002 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1138383001003 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138383001004 minor groove reading motif; other site 1138383001005 helix-hairpin-helix signature motif; other site 1138383001006 substrate binding pocket [chemical binding]; other site 1138383001007 active site 1138383001008 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1138383001009 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138383001010 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138383001011 catalytic residues [active] 1138383001012 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1138383001013 putative active site [active] 1138383001014 putative CoA binding site [chemical binding]; other site 1138383001015 nudix motif; other site 1138383001016 metal binding site [ion binding]; metal-binding site 1138383001017 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138383001018 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138383001019 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383001020 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1138383001021 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138383001022 acetyl-CoA synthetase; Provisional; Region: PRK00174 1138383001023 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1138383001024 active site 1138383001025 CoA binding site [chemical binding]; other site 1138383001026 acyl-activating enzyme (AAE) consensus motif; other site 1138383001027 AMP binding site [chemical binding]; other site 1138383001028 acetate binding site [chemical binding]; other site 1138383001029 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1138383001030 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1138383001031 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1138383001032 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1138383001033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383001034 dimer interface [polypeptide binding]; other site 1138383001035 conserved gate region; other site 1138383001036 ABC-ATPase subunit interface; other site 1138383001037 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1138383001038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383001039 dimer interface [polypeptide binding]; other site 1138383001040 conserved gate region; other site 1138383001041 putative PBP binding loops; other site 1138383001042 ABC-ATPase subunit interface; other site 1138383001043 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1138383001044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138383001045 Walker A/P-loop; other site 1138383001046 ATP binding site [chemical binding]; other site 1138383001047 Q-loop/lid; other site 1138383001048 ABC transporter signature motif; other site 1138383001049 Walker B; other site 1138383001050 D-loop; other site 1138383001051 H-loop/switch region; other site 1138383001052 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138383001053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138383001054 Walker A/P-loop; other site 1138383001055 ATP binding site [chemical binding]; other site 1138383001056 Q-loop/lid; other site 1138383001057 ABC transporter signature motif; other site 1138383001058 Walker B; other site 1138383001059 D-loop; other site 1138383001060 H-loop/switch region; other site 1138383001061 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138383001062 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138383001063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383001064 motif II; other site 1138383001065 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1138383001066 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1138383001067 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1138383001068 hexamer interface [polypeptide binding]; other site 1138383001069 Walker B motif; other site 1138383001070 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1138383001071 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1138383001072 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138383001073 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383001074 Phage capsid family; Region: Phage_capsid; pfam05065 1138383001075 potential frameshift: common BLAST hit: gi|119855043|ref|YP_935648.1| integrase catalytic subunit 1138383001076 Integrase core domain; Region: rve_3; pfam13683 1138383001077 HTH-like domain; Region: HTH_21; pfam13276 1138383001078 Transposase; Region: HTH_Tnp_1; cl17663 1138383001079 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383001080 Phage capsid family; Region: Phage_capsid; pfam05065 1138383001081 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1138383001082 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1138383001083 catalytic residues [active] 1138383001084 Recombinase; Region: Recombinase; pfam07508 1138383001085 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1138383001086 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1138383001087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383001088 ATP binding site [chemical binding]; other site 1138383001089 putative Mg++ binding site [ion binding]; other site 1138383001090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383001091 nucleotide binding region [chemical binding]; other site 1138383001092 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1138383001093 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138383001094 DNA-binding site [nucleotide binding]; DNA binding site 1138383001095 RNA-binding motif; other site 1138383001096 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1138383001097 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1138383001098 active site 1138383001099 interdomain interaction site; other site 1138383001100 putative metal-binding site [ion binding]; other site 1138383001101 nucleotide binding site [chemical binding]; other site 1138383001102 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1138383001103 domain I; other site 1138383001104 phosphate binding site [ion binding]; other site 1138383001105 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1138383001106 domain II; other site 1138383001107 domain III; other site 1138383001108 nucleotide binding site [chemical binding]; other site 1138383001109 DNA binding groove [nucleotide binding] 1138383001110 catalytic site [active] 1138383001111 domain IV; other site 1138383001112 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138383001113 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138383001114 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138383001115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138383001116 dimerization interface [polypeptide binding]; other site 1138383001117 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383001118 cyclase homology domain; Region: CHD; cd07302 1138383001119 nucleotidyl binding site; other site 1138383001120 metal binding site [ion binding]; metal-binding site 1138383001121 dimer interface [polypeptide binding]; other site 1138383001122 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1138383001123 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1138383001124 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383001125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383001126 NAD(P) binding site [chemical binding]; other site 1138383001127 active site 1138383001128 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138383001129 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138383001130 Ligand binding site; other site 1138383001131 Putative Catalytic site; other site 1138383001132 DXD motif; other site 1138383001133 Protein of unknown function (DUF475); Region: DUF475; pfam04332 1138383001134 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1138383001135 dimer interface [polypeptide binding]; other site 1138383001136 substrate binding site [chemical binding]; other site 1138383001137 metal binding sites [ion binding]; metal-binding site 1138383001138 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1138383001139 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1138383001140 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138383001141 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1138383001142 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1138383001143 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1138383001144 Ligand Binding Site [chemical binding]; other site 1138383001145 TilS substrate binding domain; Region: TilS; pfam09179 1138383001146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383001147 active site 1138383001148 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1138383001149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383001150 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383001151 salt bridge; other site 1138383001152 non-specific DNA binding site [nucleotide binding]; other site 1138383001153 sequence-specific DNA binding site [nucleotide binding]; other site 1138383001154 PE family; Region: PE; pfam00934 1138383001155 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383001156 PPE family; Region: PPE; pfam00823 1138383001157 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383001158 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383001159 active site 1138383001160 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383001161 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1138383001162 putative NAD(P) binding site [chemical binding]; other site 1138383001163 catalytic Zn binding site [ion binding]; other site 1138383001164 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383001165 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138383001166 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383001167 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383001168 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138383001169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383001170 active site 1138383001171 metal binding site [ion binding]; metal-binding site 1138383001172 FtsH Extracellular; Region: FtsH_ext; pfam06480 1138383001173 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1138383001174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383001175 Walker A motif; other site 1138383001176 ATP binding site [chemical binding]; other site 1138383001177 Walker B motif; other site 1138383001178 arginine finger; other site 1138383001179 Peptidase family M41; Region: Peptidase_M41; pfam01434 1138383001180 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1138383001181 homodecamer interface [polypeptide binding]; other site 1138383001182 GTP cyclohydrolase I; Provisional; Region: PLN03044 1138383001183 active site 1138383001184 putative catalytic site residues [active] 1138383001185 zinc binding site [ion binding]; other site 1138383001186 GTP-CH-I/GFRP interaction surface; other site 1138383001187 dihydropteroate synthase; Region: DHPS; TIGR01496 1138383001188 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1138383001189 substrate binding pocket [chemical binding]; other site 1138383001190 dimer interface [polypeptide binding]; other site 1138383001191 inhibitor binding site; inhibition site 1138383001192 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1138383001193 active site 1138383001194 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1138383001195 catalytic center binding site [active] 1138383001196 ATP binding site [chemical binding]; other site 1138383001197 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1138383001198 Rossmann-like domain; Region: Rossmann-like; pfam10727 1138383001199 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1138383001200 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1138383001201 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1138383001202 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1138383001203 active site 1138383001204 ATP-binding site [chemical binding]; other site 1138383001205 pantoate-binding site; other site 1138383001206 HXXH motif; other site 1138383001207 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1138383001208 tetramerization interface [polypeptide binding]; other site 1138383001209 active site 1138383001210 pantothenate kinase; Reviewed; Region: PRK13318 1138383001211 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1138383001212 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138383001213 dimer interface [polypeptide binding]; other site 1138383001214 putative anticodon binding site; other site 1138383001215 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138383001216 motif 1; other site 1138383001217 dimer interface [polypeptide binding]; other site 1138383001218 active site 1138383001219 motif 2; other site 1138383001220 motif 3; other site 1138383001221 Lsr2; Region: Lsr2; pfam11774 1138383001222 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1138383001223 Clp amino terminal domain; Region: Clp_N; pfam02861 1138383001224 Clp amino terminal domain; Region: Clp_N; pfam02861 1138383001225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383001226 Walker A motif; other site 1138383001227 ATP binding site [chemical binding]; other site 1138383001228 Walker B motif; other site 1138383001229 arginine finger; other site 1138383001230 UvrB/uvrC motif; Region: UVR; pfam02151 1138383001231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383001232 Walker A motif; other site 1138383001233 ATP binding site [chemical binding]; other site 1138383001234 Walker B motif; other site 1138383001235 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138383001236 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1138383001237 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1138383001238 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1138383001239 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383001240 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138383001241 catalytic site [active] 1138383001242 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138383001243 minor groove reading motif; other site 1138383001244 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138383001245 helix-hairpin-helix signature motif; other site 1138383001246 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1138383001247 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1138383001248 active site clefts [active] 1138383001249 zinc binding site [ion binding]; other site 1138383001250 dimer interface [polypeptide binding]; other site 1138383001251 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1138383001252 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1138383001253 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1138383001254 DNA repair protein RadA; Provisional; Region: PRK11823 1138383001255 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1138383001256 Walker A motif/ATP binding site; other site 1138383001257 ATP binding site [chemical binding]; other site 1138383001258 Walker B motif; other site 1138383001259 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138383001260 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1138383001261 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1138383001262 substrate binding site; other site 1138383001263 dimer interface; other site 1138383001264 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1138383001265 homotrimer interaction site [polypeptide binding]; other site 1138383001266 zinc binding site [ion binding]; other site 1138383001267 CDP-binding sites; other site 1138383001268 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1138383001269 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383001270 active site 1138383001271 HIGH motif; other site 1138383001272 nucleotide binding site [chemical binding]; other site 1138383001273 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1138383001274 KMSKS motif; other site 1138383001275 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1138383001276 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138383001277 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1138383001278 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138383001279 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1138383001280 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138383001281 active site 1138383001282 catalytic site [active] 1138383001283 metal binding site [ion binding]; metal-binding site 1138383001284 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1138383001285 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1138383001286 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138383001287 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138383001288 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1138383001289 putative active site [active] 1138383001290 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383001291 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1138383001292 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1138383001293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383001294 Walker A/P-loop; other site 1138383001295 ATP binding site [chemical binding]; other site 1138383001296 Q-loop/lid; other site 1138383001297 ABC transporter signature motif; other site 1138383001298 Walker B; other site 1138383001299 D-loop; other site 1138383001300 H-loop/switch region; other site 1138383001301 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138383001302 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1138383001303 intersubunit interface [polypeptide binding]; other site 1138383001304 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1138383001305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1138383001306 DNA binding site [nucleotide binding] 1138383001307 domain linker motif; other site 1138383001308 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1138383001309 putative dimerization interface [polypeptide binding]; other site 1138383001310 putative ligand binding site [chemical binding]; other site 1138383001311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383001312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001314 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383001315 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001316 active site 1138383001317 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001318 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001319 active site 1138383001320 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383001321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001322 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1138383001323 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383001324 putative NAD(P) binding site [chemical binding]; other site 1138383001325 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138383001326 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138383001327 FAD binding pocket [chemical binding]; other site 1138383001328 FAD binding motif [chemical binding]; other site 1138383001329 phosphate binding motif [ion binding]; other site 1138383001330 beta-alpha-beta structure motif; other site 1138383001331 NAD(p) ribose binding residues [chemical binding]; other site 1138383001332 NAD binding pocket [chemical binding]; other site 1138383001333 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138383001334 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383001335 catalytic loop [active] 1138383001336 iron binding site [ion binding]; other site 1138383001337 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001338 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1138383001339 Flavin binding site [chemical binding]; other site 1138383001340 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1138383001341 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138383001342 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138383001343 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1138383001344 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1138383001345 active site 1138383001346 Fe binding site [ion binding]; other site 1138383001347 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138383001348 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1138383001349 aspartate aminotransferase; Provisional; Region: PRK05764 1138383001350 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383001351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383001352 homodimer interface [polypeptide binding]; other site 1138383001353 catalytic residue [active] 1138383001354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001355 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383001356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001357 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138383001358 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383001359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001360 active site 1138383001361 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001363 active site 1138383001364 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1138383001365 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383001366 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138383001367 acyl-activating enzyme (AAE) consensus motif; other site 1138383001368 acyl-activating enzyme (AAE) consensus motif; other site 1138383001369 putative AMP binding site [chemical binding]; other site 1138383001370 putative active site [active] 1138383001371 putative CoA binding site [chemical binding]; other site 1138383001372 CoA binding site [chemical binding]; other site 1138383001373 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001374 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001375 active site 1138383001376 short chain dehydrogenase; Provisional; Region: PRK07831 1138383001377 classical (c) SDRs; Region: SDR_c; cd05233 1138383001378 NAD(P) binding site [chemical binding]; other site 1138383001379 active site 1138383001380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383001381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001382 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1138383001383 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138383001384 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383001385 dimer interface [polypeptide binding]; other site 1138383001386 active site 1138383001387 Nitronate monooxygenase; Region: NMO; pfam03060 1138383001388 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383001389 FMN binding site [chemical binding]; other site 1138383001390 substrate binding site [chemical binding]; other site 1138383001391 putative catalytic residue [active] 1138383001392 Coenzyme A transferase; Region: CoA_trans; cl17247 1138383001393 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138383001394 enoyl-CoA hydratase; Provisional; Region: PRK06495 1138383001395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383001396 substrate binding site [chemical binding]; other site 1138383001397 oxyanion hole (OAH) forming residues; other site 1138383001398 trimer interface [polypeptide binding]; other site 1138383001399 short chain dehydrogenase; Provisional; Region: PRK07856 1138383001400 classical (c) SDRs; Region: SDR_c; cd05233 1138383001401 NAD(P) binding site [chemical binding]; other site 1138383001402 active site 1138383001403 short chain dehydrogenase; Provisional; Region: PRK07791 1138383001404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383001405 NAD(P) binding site [chemical binding]; other site 1138383001406 active site 1138383001407 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383001408 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383001409 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1138383001410 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383001411 dimer interface [polypeptide binding]; other site 1138383001412 active site 1138383001413 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383001414 Cytochrome P450; Region: p450; cl12078 1138383001415 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001416 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383001417 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001418 active site 1138383001419 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001421 active site 1138383001422 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138383001423 active site 1138383001424 catalytic site [active] 1138383001425 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138383001426 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383001427 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138383001428 putative active site [active] 1138383001429 putative catalytic site [active] 1138383001430 lipid-transfer protein; Provisional; Region: PRK07855 1138383001431 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383001432 active site 1138383001433 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138383001434 putative active site [active] 1138383001435 enoyl-CoA hydratase; Region: PLN02864 1138383001436 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1138383001437 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138383001438 dimer interaction site [polypeptide binding]; other site 1138383001439 substrate-binding tunnel; other site 1138383001440 active site 1138383001441 catalytic site [active] 1138383001442 substrate binding site [chemical binding]; other site 1138383001443 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1138383001444 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138383001445 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1138383001446 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1138383001447 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138383001448 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1138383001449 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1138383001450 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1138383001451 active site 1138383001452 catalytic residues [active] 1138383001453 metal binding site [ion binding]; metal-binding site 1138383001454 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1138383001455 short chain dehydrogenase; Provisional; Region: PRK07890 1138383001456 classical (c) SDRs; Region: SDR_c; cd05233 1138383001457 NAD(P) binding site [chemical binding]; other site 1138383001458 active site 1138383001459 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1138383001460 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138383001461 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383001462 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1138383001463 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1138383001464 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1138383001465 trimer interface [polypeptide binding]; other site 1138383001466 putative metal binding site [ion binding]; other site 1138383001467 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383001468 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1138383001469 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383001470 active site 1138383001471 lipid-transfer protein; Provisional; Region: PRK07937 1138383001472 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383001473 active site 1138383001474 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138383001475 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138383001476 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383001477 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383001478 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138383001479 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1138383001480 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383001481 Cytochrome P450; Region: p450; cl12078 1138383001482 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138383001483 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138383001484 putative active site [active] 1138383001485 enoyl-CoA hydratase; Provisional; Region: PRK07799 1138383001486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383001487 substrate binding site [chemical binding]; other site 1138383001488 oxyanion hole (OAH) forming residues; other site 1138383001489 trimer interface [polypeptide binding]; other site 1138383001490 acyl-CoA synthetase; Validated; Region: PRK07798 1138383001491 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383001492 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138383001493 acyl-activating enzyme (AAE) consensus motif; other site 1138383001494 acyl-activating enzyme (AAE) consensus motif; other site 1138383001495 putative AMP binding site [chemical binding]; other site 1138383001496 putative active site [active] 1138383001497 putative CoA binding site [chemical binding]; other site 1138383001498 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1138383001499 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383001500 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1138383001501 hypothetical protein; Validated; Region: PRK07586 1138383001502 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138383001503 PYR/PP interface [polypeptide binding]; other site 1138383001504 dimer interface [polypeptide binding]; other site 1138383001505 TPP binding site [chemical binding]; other site 1138383001506 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1138383001507 TPP-binding site [chemical binding]; other site 1138383001508 dimer interface [polypeptide binding]; other site 1138383001509 acyl-CoA synthetase; Validated; Region: PRK07867 1138383001510 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138383001511 acyl-activating enzyme (AAE) consensus motif; other site 1138383001512 putative AMP binding site [chemical binding]; other site 1138383001513 putative active site [active] 1138383001514 putative CoA binding site [chemical binding]; other site 1138383001515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001516 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383001517 active site 1138383001518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001519 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138383001520 FAD binding site [chemical binding]; other site 1138383001521 substrate binding site [chemical binding]; other site 1138383001522 catalytic base [active] 1138383001523 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1138383001524 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1138383001525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383001526 NAD(P) binding site [chemical binding]; other site 1138383001527 active site 1138383001528 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383001529 Permease; Region: Permease; pfam02405 1138383001530 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383001531 Permease; Region: Permease; pfam02405 1138383001532 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383001533 mce related protein; Region: MCE; pfam02470 1138383001534 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383001535 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383001536 mce related protein; Region: MCE; pfam02470 1138383001537 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383001538 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383001539 mce related protein; Region: MCE; pfam02470 1138383001540 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1138383001541 mce related protein; Region: MCE; pfam02470 1138383001542 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383001543 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383001544 mce related protein; Region: MCE; pfam02470 1138383001545 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383001546 mce related protein; Region: MCE; pfam02470 1138383001547 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1138383001548 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1138383001549 active site 1138383001550 homotetramer interface [polypeptide binding]; other site 1138383001551 enoyl-CoA hydratase; Provisional; Region: PRK08290 1138383001552 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383001553 substrate binding site [chemical binding]; other site 1138383001554 oxyanion hole (OAH) forming residues; other site 1138383001555 trimer interface [polypeptide binding]; other site 1138383001556 short chain dehydrogenase; Provisional; Region: PRK05875 1138383001557 classical (c) SDRs; Region: SDR_c; cd05233 1138383001558 NAD(P) binding site [chemical binding]; other site 1138383001559 active site 1138383001560 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383001561 classical (c) SDRs; Region: SDR_c; cd05233 1138383001562 NAD(P) binding site [chemical binding]; other site 1138383001563 active site 1138383001564 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138383001565 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138383001566 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138383001567 Amidase; Region: Amidase; cl11426 1138383001568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383001569 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138383001570 Peptidase family S64; Region: Peptidase_S64; pfam08192 1138383001571 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138383001572 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138383001573 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138383001574 catalytic residue [active] 1138383001575 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383001576 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383001577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383001578 active site 1138383001579 phosphorylation site [posttranslational modification] 1138383001580 intermolecular recognition site; other site 1138383001581 dimerization interface [polypeptide binding]; other site 1138383001582 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383001583 DNA binding site [nucleotide binding] 1138383001584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383001585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138383001586 dimerization interface [polypeptide binding]; other site 1138383001587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383001588 dimer interface [polypeptide binding]; other site 1138383001589 phosphorylation site [posttranslational modification] 1138383001590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383001591 ATP binding site [chemical binding]; other site 1138383001592 Mg2+ binding site [ion binding]; other site 1138383001593 G-X-G motif; other site 1138383001594 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1138383001595 nucleotide binding site/active site [active] 1138383001596 HIT family signature motif; other site 1138383001597 catalytic residue [active] 1138383001598 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138383001599 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138383001600 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138383001601 NAD binding site [chemical binding]; other site 1138383001602 catalytic Zn binding site [ion binding]; other site 1138383001603 substrate binding site [chemical binding]; other site 1138383001604 structural Zn binding site [ion binding]; other site 1138383001605 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138383001606 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138383001607 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383001608 Cytochrome P450; Region: p450; cl12078 1138383001609 short chain dehydrogenase; Provisional; Region: PRK07775 1138383001610 classical (c) SDRs; Region: SDR_c; cd05233 1138383001611 NAD(P) binding site [chemical binding]; other site 1138383001612 active site 1138383001613 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383001614 Cytochrome P450; Region: p450; cl12078 1138383001615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383001616 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138383001617 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138383001618 NAD binding site [chemical binding]; other site 1138383001619 catalytic residues [active] 1138383001620 short chain dehydrogenase; Provisional; Region: PRK07774 1138383001621 classical (c) SDRs; Region: SDR_c; cd05233 1138383001622 NAD(P) binding site [chemical binding]; other site 1138383001623 active site 1138383001624 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138383001625 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383001626 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1138383001627 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138383001628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383001629 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383001630 active site 1138383001631 catalytic tetrad [active] 1138383001632 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383001633 MarR family; Region: MarR; pfam01047 1138383001634 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1138383001635 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1138383001636 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1138383001637 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1138383001638 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1138383001639 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1138383001640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138383001641 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1138383001642 adenylosuccinate lyase; Region: purB; TIGR00928 1138383001643 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1138383001644 tetramer interface [polypeptide binding]; other site 1138383001645 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383001646 Cytochrome P450; Region: p450; cl12078 1138383001647 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1138383001648 gating phenylalanine in ion channel; other site 1138383001649 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1138383001650 ATP binding site [chemical binding]; other site 1138383001651 active site 1138383001652 substrate binding site [chemical binding]; other site 1138383001653 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1138383001654 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383001655 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138383001656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383001657 putative substrate translocation pore; other site 1138383001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383001659 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138383001660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383001661 putative substrate translocation pore; other site 1138383001662 Predicted deacetylase [General function prediction only]; Region: COG3233 1138383001663 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1138383001664 putative active site [active] 1138383001665 putative Zn binding site [ion binding]; other site 1138383001666 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138383001667 FAD binding domain; Region: FAD_binding_2; pfam00890 1138383001668 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138383001669 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1138383001670 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1138383001671 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1138383001672 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1138383001673 putative active site [active] 1138383001674 catalytic triad [active] 1138383001675 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383001676 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383001677 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138383001678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138383001679 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383001680 putative acyl-acceptor binding pocket; other site 1138383001681 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383001682 extended (e) SDRs; Region: SDR_e; cd08946 1138383001683 NAD(P) binding site [chemical binding]; other site 1138383001684 active site 1138383001685 substrate binding site [chemical binding]; other site 1138383001686 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1138383001687 Cupin domain; Region: Cupin_2; cl17218 1138383001688 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1138383001689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383001690 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383001691 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1138383001692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383001693 motif II; other site 1138383001694 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1138383001695 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1138383001696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383001697 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138383001698 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138383001699 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1138383001700 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138383001701 putative NAD(P) binding site [chemical binding]; other site 1138383001702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383001703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001705 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383001706 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383001707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1138383001708 MOSC domain; Region: MOSC; pfam03473 1138383001709 3-alpha domain; Region: 3-alpha; pfam03475 1138383001710 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1138383001711 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138383001712 FAD binding pocket [chemical binding]; other site 1138383001713 FAD binding motif [chemical binding]; other site 1138383001714 phosphate binding motif [ion binding]; other site 1138383001715 beta-alpha-beta structure motif; other site 1138383001716 NAD binding pocket [chemical binding]; other site 1138383001717 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1138383001718 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1138383001719 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1138383001720 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1138383001721 active site 1138383001722 metal binding site [ion binding]; metal-binding site 1138383001723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383001724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001725 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383001726 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383001727 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1138383001728 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1138383001729 dimerization interface [polypeptide binding]; other site 1138383001730 ATP binding site [chemical binding]; other site 1138383001731 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1138383001732 dimerization interface [polypeptide binding]; other site 1138383001733 ATP binding site [chemical binding]; other site 1138383001734 CAAX protease self-immunity; Region: Abi; pfam02517 1138383001735 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383001736 mce related protein; Region: MCE; pfam02470 1138383001737 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383001738 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1138383001739 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1138383001740 active site 1138383001741 tetramer interface [polypeptide binding]; other site 1138383001742 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383001743 active site 1138383001744 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1138383001745 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1138383001746 dimerization interface [polypeptide binding]; other site 1138383001747 putative ATP binding site [chemical binding]; other site 1138383001748 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1138383001749 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1138383001750 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1138383001751 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1138383001752 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1138383001753 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1138383001754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383001755 catalytic residue [active] 1138383001756 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138383001757 heme-binding site [chemical binding]; other site 1138383001758 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1138383001759 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138383001760 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138383001761 active site residue [active] 1138383001762 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138383001763 active site residue [active] 1138383001764 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1138383001765 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138383001766 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138383001767 catalytic residues [active] 1138383001768 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138383001769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383001770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383001771 DNA binding site [nucleotide binding] 1138383001772 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1138383001773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383001774 Coenzyme A binding pocket [chemical binding]; other site 1138383001775 PBP superfamily domain; Region: PBP_like_2; cl17296 1138383001776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383001777 dimer interface [polypeptide binding]; other site 1138383001778 conserved gate region; other site 1138383001779 putative PBP binding loops; other site 1138383001780 ABC-ATPase subunit interface; other site 1138383001781 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1138383001782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383001783 dimer interface [polypeptide binding]; other site 1138383001784 conserved gate region; other site 1138383001785 putative PBP binding loops; other site 1138383001786 ABC-ATPase subunit interface; other site 1138383001787 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1138383001788 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138383001789 Walker A/P-loop; other site 1138383001790 ATP binding site [chemical binding]; other site 1138383001791 Q-loop/lid; other site 1138383001792 ABC transporter signature motif; other site 1138383001793 Walker B; other site 1138383001794 D-loop; other site 1138383001795 H-loop/switch region; other site 1138383001796 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1138383001797 PhoU domain; Region: PhoU; pfam01895 1138383001798 PhoU domain; Region: PhoU; pfam01895 1138383001799 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1138383001800 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138383001801 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1138383001802 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1138383001803 FMN binding site [chemical binding]; other site 1138383001804 active site 1138383001805 catalytic residues [active] 1138383001806 substrate binding site [chemical binding]; other site 1138383001807 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1138383001808 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1138383001809 homodimer interface [polypeptide binding]; other site 1138383001810 putative substrate binding pocket [chemical binding]; other site 1138383001811 diiron center [ion binding]; other site 1138383001812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138383001813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383001814 dimerization interface [polypeptide binding]; other site 1138383001815 putative DNA binding site [nucleotide binding]; other site 1138383001816 putative Zn2+ binding site [ion binding]; other site 1138383001817 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138383001818 nucleoside/Zn binding site; other site 1138383001819 dimer interface [polypeptide binding]; other site 1138383001820 catalytic motif [active] 1138383001821 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383001822 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383001823 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1138383001824 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138383001825 active site 1138383001826 DNA binding site [nucleotide binding] 1138383001827 Int/Topo IB signature motif; other site 1138383001828 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383001829 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138383001830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383001831 DNA-binding site [nucleotide binding]; DNA binding site 1138383001832 UTRA domain; Region: UTRA; pfam07702 1138383001833 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1138383001834 nudix motif; other site 1138383001835 Divergent AAA domain; Region: AAA_4; pfam04326 1138383001836 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1138383001837 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1138383001838 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1138383001839 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1138383001840 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1138383001841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383001842 ATP binding site [chemical binding]; other site 1138383001843 putative Mg++ binding site [ion binding]; other site 1138383001844 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1138383001845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383001846 nucleotide binding region [chemical binding]; other site 1138383001847 ATP-binding site [chemical binding]; other site 1138383001848 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1138383001849 PIN domain; Region: PIN_3; pfam13470 1138383001850 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138383001851 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383001852 classical (c) SDRs; Region: SDR_c; cd05233 1138383001853 NAD(P) binding site [chemical binding]; other site 1138383001854 active site 1138383001855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383001856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001857 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383001858 Cytochrome P450; Region: p450; cl12078 1138383001859 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1138383001860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383001861 DNA-binding site [nucleotide binding]; DNA binding site 1138383001862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383001863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383001864 homodimer interface [polypeptide binding]; other site 1138383001865 catalytic residue [active] 1138383001866 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138383001867 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383001868 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1138383001869 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383001870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383001871 S-adenosylmethionine binding site [chemical binding]; other site 1138383001872 short chain dehydrogenase; Provisional; Region: PRK07890 1138383001873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383001874 NAD(P) binding site [chemical binding]; other site 1138383001875 active site 1138383001876 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1138383001877 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1138383001878 B12 binding site [chemical binding]; other site 1138383001879 cobalt ligand [ion binding]; other site 1138383001880 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138383001881 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383001882 putative CoA-transferase; Provisional; Region: PRK11430 1138383001883 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383001884 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138383001885 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138383001886 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383001887 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 1138383001888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383001889 catalytic loop [active] 1138383001890 iron binding site [ion binding]; other site 1138383001891 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138383001892 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383001893 acyl-activating enzyme (AAE) consensus motif; other site 1138383001894 AMP binding site [chemical binding]; other site 1138383001895 active site 1138383001896 CoA binding site [chemical binding]; other site 1138383001897 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383001900 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383001901 active site 1138383001902 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383001903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383001904 substrate binding site [chemical binding]; other site 1138383001905 oxyanion hole (OAH) forming residues; other site 1138383001906 trimer interface [polypeptide binding]; other site 1138383001907 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1138383001908 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1138383001909 putative acyltransferase; Provisional; Region: PRK05790 1138383001910 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383001911 dimer interface [polypeptide binding]; other site 1138383001912 active site 1138383001913 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1138383001914 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1138383001915 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1138383001916 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1138383001917 TPP-binding site [chemical binding]; other site 1138383001918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383001919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383001920 active site 1138383001921 phosphorylation site [posttranslational modification] 1138383001922 intermolecular recognition site; other site 1138383001923 dimerization interface [polypeptide binding]; other site 1138383001924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383001925 DNA binding residues [nucleotide binding] 1138383001926 dimerization interface [polypeptide binding]; other site 1138383001927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138383001928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383001929 ATP binding site [chemical binding]; other site 1138383001930 Mg2+ binding site [ion binding]; other site 1138383001931 G-X-G motif; other site 1138383001932 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138383001933 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1138383001934 conserved cys residue [active] 1138383001935 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1138383001936 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1138383001937 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383001938 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138383001939 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383001940 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383001941 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1138383001942 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383001943 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 1138383001944 active site 1138383001945 metal binding site [ion binding]; metal-binding site 1138383001946 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1138383001947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383001948 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1138383001949 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138383001950 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138383001951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383001952 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383001953 NAD(P) binding site [chemical binding]; other site 1138383001954 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1138383001955 active site 1138383001956 Putative cyclase; Region: Cyclase; pfam04199 1138383001957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383001958 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138383001959 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138383001960 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138383001961 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138383001962 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138383001963 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138383001964 short chain dehydrogenase; Provisional; Region: PRK06500 1138383001965 classical (c) SDRs; Region: SDR_c; cd05233 1138383001966 NAD(P) binding site [chemical binding]; other site 1138383001967 active site 1138383001968 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138383001969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383001970 NAD(P) binding site [chemical binding]; other site 1138383001971 active site 1138383001972 AAA ATPase domain; Region: AAA_16; pfam13191 1138383001973 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383001974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383001975 DNA binding residues [nucleotide binding] 1138383001976 dimerization interface [polypeptide binding]; other site 1138383001977 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138383001978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383001979 NAD(P) binding site [chemical binding]; other site 1138383001980 active site 1138383001981 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138383001982 active site 1138383001983 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1138383001984 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1138383001985 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1138383001986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383001987 putative ADP-binding pocket [chemical binding]; other site 1138383001988 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138383001989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383001990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383001991 Cytochrome P450; Region: p450; cl12078 1138383001992 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383001993 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383001994 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138383001995 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138383001996 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138383001997 active site 1138383001998 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138383001999 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138383002000 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138383002001 active site 1138383002002 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138383002003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002004 substrate binding site [chemical binding]; other site 1138383002005 oxyanion hole (OAH) forming residues; other site 1138383002006 trimer interface [polypeptide binding]; other site 1138383002007 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383002008 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383002009 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383002010 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383002011 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138383002012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383002013 NAD(P) binding site [chemical binding]; other site 1138383002014 active site 1138383002015 short chain dehydrogenase; Provisional; Region: PRK05876 1138383002016 classical (c) SDRs; Region: SDR_c; cd05233 1138383002017 NAD(P) binding site [chemical binding]; other site 1138383002018 active site 1138383002019 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383002020 classical (c) SDRs; Region: SDR_c; cd05233 1138383002021 NAD(P) binding site [chemical binding]; other site 1138383002022 active site 1138383002023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002025 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002027 active site 1138383002028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002029 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002030 active site 1138383002031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002033 active site 1138383002034 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383002035 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138383002036 Amidohydrolase; Region: Amidohydro_4; pfam13147 1138383002037 active site 1138383002038 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383002039 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383002040 [2Fe-2S] cluster binding site [ion binding]; other site 1138383002041 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138383002042 alpha subunit interface [polypeptide binding]; other site 1138383002043 active site 1138383002044 substrate binding site [chemical binding]; other site 1138383002045 Fe binding site [ion binding]; other site 1138383002046 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383002047 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383002048 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383002049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002051 active site 1138383002052 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383002053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002054 substrate binding site [chemical binding]; other site 1138383002055 oxyanion hole (OAH) forming residues; other site 1138383002056 trimer interface [polypeptide binding]; other site 1138383002057 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138383002058 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383002059 dimer interface [polypeptide binding]; other site 1138383002060 active site 1138383002061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002062 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383002063 Cytochrome P450; Region: p450; cl12078 1138383002064 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138383002065 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1138383002066 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138383002067 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138383002068 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383002069 Cytochrome P450; Region: p450; cl12078 1138383002070 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138383002071 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383002072 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383002073 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383002074 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138383002075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383002076 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383002077 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383002078 lipid-transfer protein; Provisional; Region: PRK07855 1138383002079 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383002080 active site 1138383002081 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383002082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383002083 NAD(P) binding site [chemical binding]; other site 1138383002084 active site 1138383002085 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138383002086 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383002087 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383002088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002090 active site 1138383002091 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138383002092 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1138383002093 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383002094 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1138383002095 iron-sulfur cluster [ion binding]; other site 1138383002096 [2Fe-2S] cluster binding site [ion binding]; other site 1138383002097 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383002098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383002099 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138383002100 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383002101 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138383002102 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138383002103 FMN binding site [chemical binding]; other site 1138383002104 dimer interface [polypeptide binding]; other site 1138383002105 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138383002106 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383002107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002108 active site 1138383002109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002110 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002111 active site 1138383002112 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138383002113 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138383002114 Integrase core domain; Region: rve; pfam00665 1138383002115 Transposase; Region: HTH_Tnp_1; cl17663 1138383002116 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383002117 putative transposase OrfB; Reviewed; Region: PHA02517 1138383002118 HTH-like domain; Region: HTH_21; pfam13276 1138383002119 Integrase core domain; Region: rve; pfam00665 1138383002120 Integrase core domain; Region: rve_3; pfam13683 1138383002121 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383002122 Cytochrome P450; Region: p450; cl12078 1138383002123 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1138383002124 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383002125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383002126 NAD(P) binding site [chemical binding]; other site 1138383002127 active site 1138383002128 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138383002129 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138383002130 NAD binding site [chemical binding]; other site 1138383002131 catalytic residues [active] 1138383002132 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383002133 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383002134 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383002135 Permease; Region: Permease; pfam02405 1138383002136 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383002137 Permease; Region: Permease; pfam02405 1138383002138 mce related protein; Region: MCE; pfam02470 1138383002139 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383002140 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383002141 mce related protein; Region: MCE; pfam02470 1138383002142 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383002143 mce related protein; Region: MCE; pfam02470 1138383002144 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383002145 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383002146 mce related protein; Region: MCE; pfam02470 1138383002147 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383002148 mce related protein; Region: MCE; pfam02470 1138383002149 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383002150 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383002151 mce related protein; Region: MCE; pfam02470 1138383002152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002154 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1138383002155 Subunit I/III interface [polypeptide binding]; other site 1138383002156 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383002157 Cytochrome P450; Region: p450; cl12078 1138383002158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002160 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383002161 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002162 substrate binding site [chemical binding]; other site 1138383002163 oxyanion hole (OAH) forming residues; other site 1138383002164 trimer interface [polypeptide binding]; other site 1138383002165 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138383002166 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383002167 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1138383002168 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383002169 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138383002170 acyl-activating enzyme (AAE) consensus motif; other site 1138383002171 acyl-activating enzyme (AAE) consensus motif; other site 1138383002172 putative AMP binding site [chemical binding]; other site 1138383002173 putative active site [active] 1138383002174 putative CoA binding site [chemical binding]; other site 1138383002175 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1138383002176 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1138383002177 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1138383002178 dimer interface [polypeptide binding]; other site 1138383002179 PYR/PP interface [polypeptide binding]; other site 1138383002180 TPP binding site [chemical binding]; other site 1138383002181 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383002182 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1138383002183 TPP-binding site [chemical binding]; other site 1138383002184 dimer interface [polypeptide binding]; other site 1138383002185 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138383002186 putative hydrophobic ligand binding site [chemical binding]; other site 1138383002187 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383002188 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383002189 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138383002190 putative hydrophobic ligand binding site [chemical binding]; other site 1138383002191 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138383002192 putative hydrophobic ligand binding site [chemical binding]; other site 1138383002193 aminotransferase; Validated; Region: PRK07777 1138383002194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383002195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383002196 homodimer interface [polypeptide binding]; other site 1138383002197 catalytic residue [active] 1138383002198 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1138383002199 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383002200 dimer interface [polypeptide binding]; other site 1138383002201 active site 1138383002202 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383002203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002204 substrate binding site [chemical binding]; other site 1138383002205 oxyanion hole (OAH) forming residues; other site 1138383002206 trimer interface [polypeptide binding]; other site 1138383002207 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1138383002208 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138383002209 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138383002210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383002211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383002212 S-adenosylmethionine binding site [chemical binding]; other site 1138383002213 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138383002214 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138383002215 hypothetical protein; Provisional; Region: PRK07588 1138383002216 hypothetical protein; Provisional; Region: PRK07236 1138383002217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002219 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383002220 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138383002221 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1138383002222 Cupin; Region: Cupin_6; pfam12852 1138383002223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138383002224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383002225 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1138383002226 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383002227 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383002228 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138383002229 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383002230 active site 1138383002231 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138383002232 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138383002233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138383002234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383002235 ATP binding site [chemical binding]; other site 1138383002236 putative Mg++ binding site [ion binding]; other site 1138383002237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383002238 nucleotide binding region [chemical binding]; other site 1138383002239 ATP-binding site [chemical binding]; other site 1138383002240 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138383002241 WYL domain; Region: WYL; pfam13280 1138383002242 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1138383002243 trimer interface [polypeptide binding]; other site 1138383002244 dimer interface [polypeptide binding]; other site 1138383002245 putative active site [active] 1138383002246 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138383002247 MPT binding site; other site 1138383002248 trimer interface [polypeptide binding]; other site 1138383002249 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1138383002250 MoaE homodimer interface [polypeptide binding]; other site 1138383002251 MoaD interaction [polypeptide binding]; other site 1138383002252 active site residues [active] 1138383002253 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138383002254 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1138383002255 MoaE interaction surface [polypeptide binding]; other site 1138383002256 MoeB interaction surface [polypeptide binding]; other site 1138383002257 thiocarboxylated glycine; other site 1138383002258 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1138383002259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383002260 FeS/SAM binding site; other site 1138383002261 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1138383002262 hypothetical protein; Provisional; Region: PRK11770 1138383002263 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138383002264 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138383002265 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138383002266 DNA-binding site [nucleotide binding]; DNA binding site 1138383002267 RNA-binding motif; other site 1138383002268 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002269 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002270 active site 1138383002271 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1138383002272 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138383002273 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1138383002274 putative dimer interface [polypeptide binding]; other site 1138383002275 N-terminal domain interface [polypeptide binding]; other site 1138383002276 putative substrate binding pocket (H-site) [chemical binding]; other site 1138383002277 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1138383002278 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138383002279 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1138383002280 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383002281 hydrophobic ligand binding site; other site 1138383002282 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383002283 MarR family; Region: MarR; pfam01047 1138383002284 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138383002285 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138383002286 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1138383002287 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1138383002288 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383002289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383002290 catalytic residue [active] 1138383002291 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1138383002292 Ferredoxin [Energy production and conversion]; Region: COG1146 1138383002293 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383002294 ferredoxin-NADP+ reductase; Region: PLN02852 1138383002295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383002296 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1138383002297 putative dimer interface [polypeptide binding]; other site 1138383002298 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383002299 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1138383002300 dimer interface [polypeptide binding]; other site 1138383002301 Citrate synthase; Region: Citrate_synt; pfam00285 1138383002302 active site 1138383002303 citrylCoA binding site [chemical binding]; other site 1138383002304 oxalacetate/citrate binding site [chemical binding]; other site 1138383002305 coenzyme A binding site [chemical binding]; other site 1138383002306 catalytic triad [active] 1138383002307 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1138383002308 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138383002309 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1138383002310 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1138383002311 active site 1138383002312 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1138383002313 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1138383002314 dimer interface [polypeptide binding]; other site 1138383002315 active site 1138383002316 citrylCoA binding site [chemical binding]; other site 1138383002317 NADH binding [chemical binding]; other site 1138383002318 cationic pore residues; other site 1138383002319 oxalacetate/citrate binding site [chemical binding]; other site 1138383002320 coenzyme A binding site [chemical binding]; other site 1138383002321 catalytic triad [active] 1138383002322 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138383002323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383002324 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1138383002325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383002326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383002327 dimer interface [polypeptide binding]; other site 1138383002328 phosphorylation site [posttranslational modification] 1138383002329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383002330 ATP binding site [chemical binding]; other site 1138383002331 Mg2+ binding site [ion binding]; other site 1138383002332 G-X-G motif; other site 1138383002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383002334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383002335 active site 1138383002336 phosphorylation site [posttranslational modification] 1138383002337 intermolecular recognition site; other site 1138383002338 dimerization interface [polypeptide binding]; other site 1138383002339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383002340 DNA binding site [nucleotide binding] 1138383002341 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138383002342 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1138383002343 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383002344 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383002345 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002346 substrate binding site [chemical binding]; other site 1138383002347 oxyanion hole (OAH) forming residues; other site 1138383002348 trimer interface [polypeptide binding]; other site 1138383002349 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138383002350 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138383002351 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383002352 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383002353 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1138383002354 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1138383002355 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138383002356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383002357 motif II; other site 1138383002358 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1138383002359 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383002360 hydrophobic ligand binding site; other site 1138383002361 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138383002362 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383002363 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138383002364 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383002365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383002366 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383002367 active site 1138383002368 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138383002369 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138383002370 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1138383002371 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383002372 active site 1138383002373 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138383002374 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383002375 PPE family; Region: PPE; pfam00823 1138383002376 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383002377 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383002378 PPE family; Region: PPE; pfam00823 1138383002379 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1138383002380 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383002381 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138383002382 dimerization interface [polypeptide binding]; other site 1138383002383 putative catalytic residue [active] 1138383002384 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1138383002385 manganese transport protein MntH; Reviewed; Region: PRK00701 1138383002386 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138383002387 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383002388 short chain dehydrogenase; Provisional; Region: PRK07814 1138383002389 classical (c) SDRs; Region: SDR_c; cd05233 1138383002390 NAD(P) binding site [chemical binding]; other site 1138383002391 active site 1138383002392 PBP superfamily domain; Region: PBP_like_2; cl17296 1138383002393 PBP superfamily domain; Region: PBP_like_2; cl17296 1138383002394 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138383002395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383002396 dimer interface [polypeptide binding]; other site 1138383002397 conserved gate region; other site 1138383002398 putative PBP binding loops; other site 1138383002399 ABC-ATPase subunit interface; other site 1138383002400 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138383002401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383002402 dimer interface [polypeptide binding]; other site 1138383002403 conserved gate region; other site 1138383002404 putative PBP binding loops; other site 1138383002405 ABC-ATPase subunit interface; other site 1138383002406 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1138383002407 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1138383002408 putative DNA binding site [nucleotide binding]; other site 1138383002409 putative homodimer interface [polypeptide binding]; other site 1138383002410 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138383002411 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1138383002412 putative substrate binding site [chemical binding]; other site 1138383002413 putative ATP binding site [chemical binding]; other site 1138383002414 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1138383002415 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1138383002416 nucleotide binding site [chemical binding]; other site 1138383002417 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1138383002418 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1138383002419 active site 1138383002420 DNA binding site [nucleotide binding] 1138383002421 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1138383002422 DNA binding site [nucleotide binding] 1138383002423 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138383002424 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138383002425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383002426 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383002427 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383002428 enoyl-CoA hydratase; Provisional; Region: PRK08260 1138383002429 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002430 substrate binding site [chemical binding]; other site 1138383002431 oxyanion hole (OAH) forming residues; other site 1138383002432 trimer interface [polypeptide binding]; other site 1138383002433 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383002434 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383002435 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383002436 anti sigma factor interaction site; other site 1138383002437 regulatory phosphorylation site [posttranslational modification]; other site 1138383002438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383002439 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383002440 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1138383002441 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1138383002442 active site 1138383002443 SAM binding site [chemical binding]; other site 1138383002444 homodimer interface [polypeptide binding]; other site 1138383002445 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138383002446 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1138383002447 putative DNA binding site [nucleotide binding]; other site 1138383002448 catalytic residue [active] 1138383002449 putative H2TH interface [polypeptide binding]; other site 1138383002450 putative catalytic residues [active] 1138383002451 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138383002452 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138383002453 short chain dehydrogenase; Provisional; Region: PRK08251 1138383002454 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1138383002455 putative NAD(P) binding site [chemical binding]; other site 1138383002456 active site 1138383002457 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1138383002458 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1138383002459 active site 1138383002460 dimer interface [polypeptide binding]; other site 1138383002461 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1138383002462 dimer interface [polypeptide binding]; other site 1138383002463 active site 1138383002464 Chorismate mutase type II; Region: CM_2; cl00693 1138383002465 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1138383002466 Part of AAA domain; Region: AAA_19; pfam13245 1138383002467 Family description; Region: UvrD_C_2; pfam13538 1138383002468 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138383002469 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138383002470 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1138383002471 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1138383002472 CoA-ligase; Region: Ligase_CoA; pfam00549 1138383002473 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1138383002474 CoA binding domain; Region: CoA_binding; smart00881 1138383002475 CoA-ligase; Region: Ligase_CoA; pfam00549 1138383002476 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138383002477 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383002478 Omptin family; Region: Omptin; cl01886 1138383002479 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383002480 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383002481 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1138383002482 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1138383002483 active site 1138383002484 substrate binding site [chemical binding]; other site 1138383002485 cosubstrate binding site; other site 1138383002486 catalytic site [active] 1138383002487 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1138383002488 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1138383002489 purine monophosphate binding site [chemical binding]; other site 1138383002490 dimer interface [polypeptide binding]; other site 1138383002491 putative catalytic residues [active] 1138383002492 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1138383002493 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1138383002494 LGFP repeat; Region: LGFP; pfam08310 1138383002495 LGFP repeat; Region: LGFP; pfam08310 1138383002496 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1138383002497 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1138383002498 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1138383002499 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138383002500 metal ion-dependent adhesion site (MIDAS); other site 1138383002501 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383002502 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383002503 active site 1138383002504 catalytic tetrad [active] 1138383002505 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138383002506 enoyl-CoA hydratase; Provisional; Region: PRK07827 1138383002507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002508 substrate binding site [chemical binding]; other site 1138383002509 oxyanion hole (OAH) forming residues; other site 1138383002510 trimer interface [polypeptide binding]; other site 1138383002511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002512 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383002513 active site 1138383002514 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138383002515 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138383002516 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383002517 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138383002518 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138383002519 carboxyltransferase (CT) interaction site; other site 1138383002520 biotinylation site [posttranslational modification]; other site 1138383002521 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138383002522 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383002523 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383002524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383002525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383002526 active site 1138383002527 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1138383002528 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1138383002529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383002530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383002531 active site 1138383002532 phosphorylation site [posttranslational modification] 1138383002533 intermolecular recognition site; other site 1138383002534 dimerization interface [polypeptide binding]; other site 1138383002535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383002536 DNA binding site [nucleotide binding] 1138383002537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383002538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138383002539 dimerization interface [polypeptide binding]; other site 1138383002540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383002541 dimer interface [polypeptide binding]; other site 1138383002542 phosphorylation site [posttranslational modification] 1138383002543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383002544 ATP binding site [chemical binding]; other site 1138383002545 Mg2+ binding site [ion binding]; other site 1138383002546 G-X-G motif; other site 1138383002547 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138383002548 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138383002549 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1138383002550 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138383002551 MPT binding site; other site 1138383002552 trimer interface [polypeptide binding]; other site 1138383002553 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1138383002554 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1138383002555 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1138383002556 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1138383002557 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1138383002558 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1138383002559 active site 1138383002560 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138383002561 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138383002562 dimer interface [polypeptide binding]; other site 1138383002563 putative functional site; other site 1138383002564 putative MPT binding site; other site 1138383002565 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1138383002566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138383002567 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383002568 MarR family; Region: MarR_2; pfam12802 1138383002569 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1138383002570 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1138383002571 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383002572 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383002573 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1138383002574 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138383002575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383002576 DNA-binding site [nucleotide binding]; DNA binding site 1138383002577 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138383002578 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383002579 Cytochrome P450; Region: p450; cl12078 1138383002580 Predicted acyl esterases [General function prediction only]; Region: COG2936 1138383002581 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138383002582 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1138383002583 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138383002584 metal binding site [ion binding]; metal-binding site 1138383002585 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1138383002586 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1138383002587 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1138383002588 dimer interface [polypeptide binding]; other site 1138383002589 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1138383002590 active site 1138383002591 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1138383002592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383002593 active site 1138383002594 motif I; other site 1138383002595 motif II; other site 1138383002596 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138383002597 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138383002598 ligand binding site [chemical binding]; other site 1138383002599 flexible hinge region; other site 1138383002600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138383002601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383002602 Coenzyme A binding pocket [chemical binding]; other site 1138383002603 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1138383002604 Amidinotransferase; Region: Amidinotransf; cl12043 1138383002605 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1138383002606 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1138383002607 Predicted methyltransferases [General function prediction only]; Region: COG0313 1138383002608 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1138383002609 putative SAM binding site [chemical binding]; other site 1138383002610 putative homodimer interface [polypeptide binding]; other site 1138383002611 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1138383002612 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1138383002613 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1138383002614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383002615 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138383002616 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383002617 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138383002618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383002619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383002620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138383002621 GAF domain; Region: GAF; pfam01590 1138383002622 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138383002623 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138383002624 metal binding site [ion binding]; metal-binding site 1138383002625 active site 1138383002626 I-site; other site 1138383002627 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138383002628 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138383002629 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1138383002630 Chain length determinant protein; Region: Wzz; pfam02706 1138383002631 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1138383002632 O-Antigen ligase; Region: Wzy_C; cl04850 1138383002633 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383002634 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383002635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383002636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383002637 active site 1138383002638 catalytic tetrad [active] 1138383002639 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138383002640 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138383002641 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138383002642 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1138383002643 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1138383002644 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1138383002645 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1138383002646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383002647 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138383002648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1138383002649 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138383002650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138383002651 active site 1138383002652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138383002653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383002654 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383002655 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1138383002656 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1138383002657 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1138383002658 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1138383002659 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1138383002660 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383002661 PPE family; Region: PPE; pfam00823 1138383002662 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383002663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138383002668 PAS domain; Region: PAS_9; pfam13426 1138383002669 putative active site [active] 1138383002670 heme pocket [chemical binding]; other site 1138383002671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002672 WHG domain; Region: WHG; pfam13305 1138383002673 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1138383002674 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1138383002675 active site 1138383002676 HIGH motif; other site 1138383002677 KMSKS motif; other site 1138383002678 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1138383002679 tRNA binding surface [nucleotide binding]; other site 1138383002680 anticodon binding site; other site 1138383002681 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1138383002682 active site 1138383002683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1138383002684 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138383002685 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138383002686 G5 domain; Region: G5; pfam07501 1138383002687 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138383002688 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1138383002689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383002690 S-adenosylmethionine binding site [chemical binding]; other site 1138383002691 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1138383002692 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1138383002693 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383002694 acyl-activating enzyme (AAE) consensus motif; other site 1138383002695 AMP binding site [chemical binding]; other site 1138383002696 active site 1138383002697 CoA binding site [chemical binding]; other site 1138383002698 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1138383002699 putative active site [active] 1138383002700 catalytic residue [active] 1138383002701 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1138383002702 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1138383002703 5S rRNA interface [nucleotide binding]; other site 1138383002704 CTC domain interface [polypeptide binding]; other site 1138383002705 L16 interface [polypeptide binding]; other site 1138383002706 short chain dehydrogenase; Provisional; Region: PRK06197 1138383002707 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138383002708 putative NAD(P) binding site [chemical binding]; other site 1138383002709 active site 1138383002710 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383002711 Cytochrome P450; Region: p450; cl12078 1138383002712 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383002713 cyclase homology domain; Region: CHD; cd07302 1138383002714 nucleotidyl binding site; other site 1138383002715 metal binding site [ion binding]; metal-binding site 1138383002716 dimer interface [polypeptide binding]; other site 1138383002717 Predicted ATPase [General function prediction only]; Region: COG3903 1138383002718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383002719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383002720 DNA binding residues [nucleotide binding] 1138383002721 dimerization interface [polypeptide binding]; other site 1138383002722 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138383002723 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1138383002724 ArsC family; Region: ArsC; pfam03960 1138383002725 catalytic residues [active] 1138383002726 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1138383002727 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1138383002728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383002729 active site 1138383002730 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1138383002731 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1138383002732 Substrate binding site; other site 1138383002733 Mg++ binding site; other site 1138383002734 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1138383002735 active site 1138383002736 substrate binding site [chemical binding]; other site 1138383002737 CoA binding site [chemical binding]; other site 1138383002738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002740 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1138383002741 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1138383002742 active site 1138383002743 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138383002744 substrate binding site [chemical binding]; other site 1138383002745 catalytic residues [active] 1138383002746 dimer interface [polypeptide binding]; other site 1138383002747 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1138383002748 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1138383002749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383002750 ATP binding site [chemical binding]; other site 1138383002751 putative Mg++ binding site [ion binding]; other site 1138383002752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383002753 nucleotide binding region [chemical binding]; other site 1138383002754 ATP-binding site [chemical binding]; other site 1138383002755 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1138383002756 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1138383002757 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1138383002758 homodimer interface [polypeptide binding]; other site 1138383002759 metal binding site [ion binding]; metal-binding site 1138383002760 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138383002761 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138383002762 enolase; Provisional; Region: eno; PRK00077 1138383002763 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1138383002764 dimer interface [polypeptide binding]; other site 1138383002765 metal binding site [ion binding]; metal-binding site 1138383002766 substrate binding pocket [chemical binding]; other site 1138383002767 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1138383002768 Septum formation initiator; Region: DivIC; pfam04977 1138383002769 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1138383002770 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138383002771 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138383002772 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1138383002773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383002774 active site 1138383002775 phosphorylation site [posttranslational modification] 1138383002776 intermolecular recognition site; other site 1138383002777 dimerization interface [polypeptide binding]; other site 1138383002778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383002779 DNA binding site [nucleotide binding] 1138383002780 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1138383002781 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1138383002782 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1138383002783 Ligand Binding Site [chemical binding]; other site 1138383002784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383002785 dimer interface [polypeptide binding]; other site 1138383002786 phosphorylation site [posttranslational modification] 1138383002787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383002788 ATP binding site [chemical binding]; other site 1138383002789 Mg2+ binding site [ion binding]; other site 1138383002790 G-X-G motif; other site 1138383002791 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1138383002792 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1138383002793 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1138383002794 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138383002795 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138383002796 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1138383002797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383002798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383002799 dimer interface [polypeptide binding]; other site 1138383002800 phosphorylation site [posttranslational modification] 1138383002801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383002802 ATP binding site [chemical binding]; other site 1138383002803 Mg2+ binding site [ion binding]; other site 1138383002804 G-X-G motif; other site 1138383002805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383002806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383002807 active site 1138383002808 phosphorylation site [posttranslational modification] 1138383002809 intermolecular recognition site; other site 1138383002810 dimerization interface [polypeptide binding]; other site 1138383002811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383002812 DNA binding site [nucleotide binding] 1138383002813 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138383002814 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138383002815 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383002816 PPE family; Region: PPE; pfam00823 1138383002817 PE family; Region: PE; pfam00934 1138383002818 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383002819 Transposase; Region: HTH_Tnp_1; cl17663 1138383002820 putative cation:proton antiport protein; Provisional; Region: PRK10669 1138383002821 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138383002822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383002823 NAD(P) binding site [chemical binding]; other site 1138383002824 active site 1138383002825 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138383002826 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138383002827 putative di-iron ligands [ion binding]; other site 1138383002828 GAF domain; Region: GAF; pfam01590 1138383002829 ANTAR domain; Region: ANTAR; pfam03861 1138383002830 GAF domain; Region: GAF; pfam01590 1138383002831 GAF domain; Region: GAF; pfam01590 1138383002832 GAF domain; Region: GAF_2; pfam13185 1138383002833 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383002834 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383002835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383002836 S-adenosylmethionine binding site [chemical binding]; other site 1138383002837 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138383002838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138383002839 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138383002840 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1138383002841 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138383002842 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1138383002843 dimer interface [polypeptide binding]; other site 1138383002844 acyl-activating enzyme (AAE) consensus motif; other site 1138383002845 putative active site [active] 1138383002846 AMP binding site [chemical binding]; other site 1138383002847 putative CoA binding site [chemical binding]; other site 1138383002848 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138383002849 putative hydrophobic ligand binding site [chemical binding]; other site 1138383002850 protein interface [polypeptide binding]; other site 1138383002851 gate; other site 1138383002852 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1138383002853 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138383002854 putative active site [active] 1138383002855 putative dimer interface [polypeptide binding]; other site 1138383002856 Patatin-like phospholipase; Region: Patatin; pfam01734 1138383002857 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138383002858 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1138383002859 active site 1138383002860 nucleophile elbow; other site 1138383002861 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1138383002862 Rhodanese Homology Domain; Region: RHOD; smart00450 1138383002863 active site residue [active] 1138383002864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383002865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383002866 Predicted membrane protein [Function unknown]; Region: COG4425 1138383002867 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1138383002868 enoyl-CoA hydratase; Provisional; Region: PRK05862 1138383002869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002870 substrate binding site [chemical binding]; other site 1138383002871 oxyanion hole (OAH) forming residues; other site 1138383002872 trimer interface [polypeptide binding]; other site 1138383002873 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1138383002874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383002875 substrate binding site [chemical binding]; other site 1138383002876 oxyanion hole (OAH) forming residues; other site 1138383002877 trimer interface [polypeptide binding]; other site 1138383002878 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1138383002879 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1138383002880 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138383002881 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138383002882 Integrase core domain; Region: rve; pfam00665 1138383002883 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1138383002884 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383002885 dimer interface [polypeptide binding]; other site 1138383002886 active site 1138383002887 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1138383002888 active site 1138383002889 catalytic triad [active] 1138383002890 oxyanion hole [active] 1138383002891 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383002892 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383002893 substrate binding pocket [chemical binding]; other site 1138383002894 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1138383002895 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138383002896 dimer interface [polypeptide binding]; other site 1138383002897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383002898 catalytic residue [active] 1138383002899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1138383002900 RDD family; Region: RDD; pfam06271 1138383002901 cystathionine gamma-synthase; Provisional; Region: PRK07811 1138383002902 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138383002903 homodimer interface [polypeptide binding]; other site 1138383002904 substrate-cofactor binding pocket; other site 1138383002905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383002906 catalytic residue [active] 1138383002907 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138383002908 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1138383002909 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138383002910 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1138383002911 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1138383002912 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1138383002913 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1138383002914 catalytic residues [active] 1138383002915 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383002916 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1138383002917 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1138383002918 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138383002919 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138383002920 catalytic residue [active] 1138383002921 putative FPP diphosphate binding site; other site 1138383002922 putative FPP binding hydrophobic cleft; other site 1138383002923 dimer interface [polypeptide binding]; other site 1138383002924 putative IPP diphosphate binding site; other site 1138383002925 pantothenate kinase; Provisional; Region: PRK05439 1138383002926 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1138383002927 ATP-binding site [chemical binding]; other site 1138383002928 CoA-binding site [chemical binding]; other site 1138383002929 Mg2+-binding site [ion binding]; other site 1138383002930 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1138383002931 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1138383002932 dimer interface [polypeptide binding]; other site 1138383002933 active site 1138383002934 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1138383002935 folate binding site [chemical binding]; other site 1138383002936 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1138383002937 dinuclear metal binding motif [ion binding]; other site 1138383002938 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1138383002939 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1138383002940 putative active site [active] 1138383002941 PhoH-like protein; Region: PhoH; pfam02562 1138383002942 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1138383002943 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1138383002944 NodB motif; other site 1138383002945 active site 1138383002946 catalytic site [active] 1138383002947 metal binding site [ion binding]; metal-binding site 1138383002948 HAMP domain; Region: HAMP; pfam00672 1138383002949 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138383002950 cyclase homology domain; Region: CHD; cd07302 1138383002951 nucleotidyl binding site; other site 1138383002952 metal binding site [ion binding]; metal-binding site 1138383002953 dimer interface [polypeptide binding]; other site 1138383002954 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1138383002955 Class II fumarases; Region: Fumarase_classII; cd01362 1138383002956 active site 1138383002957 tetramer interface [polypeptide binding]; other site 1138383002958 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1138383002959 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1138383002960 putative active site [active] 1138383002961 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1138383002962 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1138383002963 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138383002964 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138383002965 homodimer interface [polypeptide binding]; other site 1138383002966 active site 1138383002967 TDP-binding site; other site 1138383002968 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383002969 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383002970 acyl-activating enzyme (AAE) consensus motif; other site 1138383002971 AMP binding site [chemical binding]; other site 1138383002972 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383002973 Condensation domain; Region: Condensation; pfam00668 1138383002974 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383002975 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138383002976 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383002977 substrate binding pocket [chemical binding]; other site 1138383002978 catalytic triad [active] 1138383002979 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1138383002980 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1138383002981 putative NAD(P) binding site [chemical binding]; other site 1138383002982 active site 1138383002983 putative substrate binding site [chemical binding]; other site 1138383002984 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1138383002985 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1138383002986 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1138383002987 generic binding surface II; other site 1138383002988 generic binding surface I; other site 1138383002989 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138383002990 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1138383002991 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1138383002992 GTP-binding protein YchF; Reviewed; Region: PRK09601 1138383002993 YchF GTPase; Region: YchF; cd01900 1138383002994 G1 box; other site 1138383002995 GTP/Mg2+ binding site [chemical binding]; other site 1138383002996 Switch I region; other site 1138383002997 G2 box; other site 1138383002998 Switch II region; other site 1138383002999 G3 box; other site 1138383003000 G4 box; other site 1138383003001 G5 box; other site 1138383003002 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1138383003003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383003004 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1138383003005 putative dimer interface [polypeptide binding]; other site 1138383003006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383003007 ligand binding site [chemical binding]; other site 1138383003008 Zn binding site [ion binding]; other site 1138383003009 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383003010 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383003011 active site 1138383003012 metal binding site [ion binding]; metal-binding site 1138383003013 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138383003014 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383003015 cyclase homology domain; Region: CHD; cd07302 1138383003016 nucleotidyl binding site; other site 1138383003017 metal binding site [ion binding]; metal-binding site 1138383003018 dimer interface [polypeptide binding]; other site 1138383003019 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1138383003020 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138383003021 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138383003022 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1138383003023 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383003024 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383003025 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383003026 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1138383003027 dimer interface [polypeptide binding]; other site 1138383003028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383003029 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383003030 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1138383003031 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1138383003032 Predicted membrane protein [Function unknown]; Region: COG2259 1138383003033 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1138383003034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383003035 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1138383003036 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1138383003037 TrkA-C domain; Region: TrkA_C; pfam02080 1138383003038 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138383003039 TrkA-N domain; Region: TrkA_N; pfam02254 1138383003040 TrkA-C domain; Region: TrkA_C; pfam02080 1138383003041 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138383003042 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1138383003043 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1138383003044 THF binding site; other site 1138383003045 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1138383003046 substrate binding site [chemical binding]; other site 1138383003047 THF binding site; other site 1138383003048 zinc-binding site [ion binding]; other site 1138383003049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003050 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138383003051 NAD(P) binding site [chemical binding]; other site 1138383003052 active site 1138383003053 short chain dehydrogenase; Provisional; Region: PRK12829 1138383003054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003055 NAD(P) binding site [chemical binding]; other site 1138383003056 active site 1138383003057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383003058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383003060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003061 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138383003062 FMN binding site [chemical binding]; other site 1138383003063 dimer interface [polypeptide binding]; other site 1138383003064 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383003065 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383003066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383003067 active site 1138383003068 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138383003069 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383003070 active site 1138383003071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003072 short chain dehydrogenase; Provisional; Region: PRK07791 1138383003073 NAD(P) binding site [chemical binding]; other site 1138383003074 active site 1138383003075 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138383003076 metal ion-dependent adhesion site (MIDAS); other site 1138383003077 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138383003078 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1138383003079 Walker A motif; other site 1138383003080 ATP binding site [chemical binding]; other site 1138383003081 Walker B motif; other site 1138383003082 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138383003083 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138383003084 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138383003085 ligand binding site [chemical binding]; other site 1138383003086 short chain dehydrogenase; Provisional; Region: PRK06914 1138383003087 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138383003088 NADP binding site [chemical binding]; other site 1138383003089 active site 1138383003090 steroid binding site; other site 1138383003091 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383003092 Cytochrome P450; Region: p450; cl12078 1138383003093 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138383003094 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138383003095 NAD binding site [chemical binding]; other site 1138383003096 catalytic residues [active] 1138383003097 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383003098 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383003099 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383003100 Cytochrome P450; Region: p450; cl12078 1138383003101 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138383003102 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383003103 putative acyl-acceptor binding pocket; other site 1138383003104 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383003105 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383003106 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138383003107 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138383003108 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383003109 dimer interface [polypeptide binding]; other site 1138383003110 active site 1138383003111 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138383003112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383003113 substrate binding site [chemical binding]; other site 1138383003114 oxyanion hole (OAH) forming residues; other site 1138383003115 trimer interface [polypeptide binding]; other site 1138383003116 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383003117 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1138383003118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1138383003119 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138383003120 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138383003121 malonyl-CoA binding site [chemical binding]; other site 1138383003122 dimer interface [polypeptide binding]; other site 1138383003123 active site 1138383003124 product binding site; other site 1138383003125 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138383003126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003127 NAD(P) binding site [chemical binding]; other site 1138383003128 active site 1138383003129 CAAX protease self-immunity; Region: Abi; pfam02517 1138383003130 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1138383003131 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138383003132 putative NAD(P) binding site [chemical binding]; other site 1138383003133 putative active site [active] 1138383003134 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383003135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383003136 substrate binding site [chemical binding]; other site 1138383003137 oxyanion hole (OAH) forming residues; other site 1138383003138 trimer interface [polypeptide binding]; other site 1138383003139 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383003140 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383003141 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1138383003142 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1138383003143 NAD binding site [chemical binding]; other site 1138383003144 homodimer interface [polypeptide binding]; other site 1138383003145 homotetramer interface [polypeptide binding]; other site 1138383003146 active site 1138383003147 MMPL family; Region: MMPL; pfam03176 1138383003148 MMPL family; Region: MMPL; pfam03176 1138383003149 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383003150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383003151 S-adenosylmethionine binding site [chemical binding]; other site 1138383003152 NAD-dependent deacetylase; Provisional; Region: PRK00481 1138383003153 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1138383003154 NAD+ binding site [chemical binding]; other site 1138383003155 substrate binding site [chemical binding]; other site 1138383003156 Zn binding site [ion binding]; other site 1138383003157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383003158 DNA-binding site [nucleotide binding]; DNA binding site 1138383003159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1138383003160 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138383003161 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138383003162 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138383003163 minor groove reading motif; other site 1138383003164 helix-hairpin-helix signature motif; other site 1138383003165 mannosyltransferase; Provisional; Region: pimE; PRK13375 1138383003166 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1138383003167 aromatic arch; other site 1138383003168 DCoH dimer interaction site [polypeptide binding]; other site 1138383003169 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1138383003170 DCoH tetramer interaction site [polypeptide binding]; other site 1138383003171 substrate binding site [chemical binding]; other site 1138383003172 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1138383003173 active site 1138383003174 8-oxo-dGMP binding site [chemical binding]; other site 1138383003175 nudix motif; other site 1138383003176 metal binding site [ion binding]; metal-binding site 1138383003177 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1138383003178 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1138383003179 [4Fe-4S] binding site [ion binding]; other site 1138383003180 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383003181 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383003182 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383003183 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1138383003184 molybdopterin cofactor binding site; other site 1138383003185 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1138383003186 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1138383003187 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1138383003188 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1138383003189 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1138383003190 G1 box; other site 1138383003191 putative GEF interaction site [polypeptide binding]; other site 1138383003192 GTP/Mg2+ binding site [chemical binding]; other site 1138383003193 Switch I region; other site 1138383003194 G2 box; other site 1138383003195 G3 box; other site 1138383003196 Switch II region; other site 1138383003197 G4 box; other site 1138383003198 G5 box; other site 1138383003199 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1138383003200 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1138383003201 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138383003202 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138383003203 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138383003204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383003205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003206 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1138383003207 FO synthase; Reviewed; Region: fbiC; PRK09234 1138383003208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383003209 FeS/SAM binding site; other site 1138383003210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383003211 FeS/SAM binding site; other site 1138383003212 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1138383003213 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383003214 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1138383003215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383003216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383003217 homodimer interface [polypeptide binding]; other site 1138383003218 catalytic residue [active] 1138383003219 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138383003220 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138383003221 generic binding surface II; other site 1138383003222 ssDNA binding site; other site 1138383003223 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383003224 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383003225 active site 1138383003226 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383003227 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138383003228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003229 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138383003230 Enoylreductase; Region: PKS_ER; smart00829 1138383003231 NAD(P) binding site [chemical binding]; other site 1138383003232 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138383003233 KR domain; Region: KR; pfam08659 1138383003234 putative NADP binding site [chemical binding]; other site 1138383003235 active site 1138383003236 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383003237 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383003238 PPE family; Region: PPE; pfam00823 1138383003239 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383003240 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383003241 PPE family; Region: PPE; pfam00823 1138383003242 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383003243 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138383003244 ligand-binding site [chemical binding]; other site 1138383003245 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1138383003246 ATP-sulfurylase; Region: ATPS; cd00517 1138383003247 active site 1138383003248 HXXH motif; other site 1138383003249 flexible loop; other site 1138383003250 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138383003251 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138383003252 acyl-CoA synthetase; Validated; Region: PRK05850 1138383003253 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138383003254 acyl-activating enzyme (AAE) consensus motif; other site 1138383003255 active site 1138383003256 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383003257 PPE family; Region: PPE; pfam00823 1138383003258 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138383003259 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138383003260 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383003261 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1138383003262 NAD(P) binding site [chemical binding]; other site 1138383003263 catalytic residues [active] 1138383003264 Proline dehydrogenase; Region: Pro_dh; cl03282 1138383003265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383003266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003267 lipid-transfer protein; Provisional; Region: PRK07855 1138383003268 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383003269 active site 1138383003270 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138383003271 putative active site [active] 1138383003272 putative catalytic site [active] 1138383003273 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383003274 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383003275 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383003276 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383003277 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138383003278 NAD binding site [chemical binding]; other site 1138383003279 catalytic residues [active] 1138383003280 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383003281 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1138383003282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383003283 acyl-CoA synthetase; Validated; Region: PRK07787 1138383003284 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003285 acyl-activating enzyme (AAE) consensus motif; other site 1138383003286 AMP binding site [chemical binding]; other site 1138383003287 active site 1138383003288 CoA binding site [chemical binding]; other site 1138383003289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383003290 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138383003291 putative substrate translocation pore; other site 1138383003292 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1138383003293 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1138383003294 putative trimer interface [polypeptide binding]; other site 1138383003295 putative CoA binding site [chemical binding]; other site 1138383003296 PE family; Region: PE; pfam00934 1138383003297 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383003298 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383003299 PPE family; Region: PPE; pfam00823 1138383003300 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1138383003301 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1138383003302 metal binding site [ion binding]; metal-binding site 1138383003303 putative dimer interface [polypeptide binding]; other site 1138383003304 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1138383003305 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1138383003306 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138383003307 acyl-activating enzyme (AAE) consensus motif; other site 1138383003308 putative AMP binding site [chemical binding]; other site 1138383003309 putative active site [active] 1138383003310 putative CoA binding site [chemical binding]; other site 1138383003311 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1138383003312 dihydropteroate synthase; Region: DHPS; TIGR01496 1138383003313 substrate binding pocket [chemical binding]; other site 1138383003314 dimer interface [polypeptide binding]; other site 1138383003315 inhibitor binding site; inhibition site 1138383003316 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1138383003317 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138383003318 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138383003319 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1138383003320 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1138383003321 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1138383003322 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383003323 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1138383003324 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1138383003325 ligand binding site; other site 1138383003326 oligomer interface; other site 1138383003327 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1138383003328 dimer interface [polypeptide binding]; other site 1138383003329 N-terminal domain interface [polypeptide binding]; other site 1138383003330 sulfate 1 binding site; other site 1138383003331 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138383003332 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1138383003333 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138383003334 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138383003335 Walker A/P-loop; other site 1138383003336 ATP binding site [chemical binding]; other site 1138383003337 Q-loop/lid; other site 1138383003338 ABC transporter signature motif; other site 1138383003339 Walker B; other site 1138383003340 D-loop; other site 1138383003341 H-loop/switch region; other site 1138383003342 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1138383003343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383003344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003345 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138383003346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383003347 S-adenosylmethionine binding site [chemical binding]; other site 1138383003348 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1138383003349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383003350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383003351 DNA binding residues [nucleotide binding] 1138383003352 Putative zinc-finger; Region: zf-HC2; pfam13490 1138383003353 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138383003354 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138383003355 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138383003356 protein binding site [polypeptide binding]; other site 1138383003357 sec-independent translocase; Provisional; Region: PRK03100 1138383003358 Domain of unknown function DUF59; Region: DUF59; cl00941 1138383003359 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1138383003360 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1138383003361 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1138383003362 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138383003363 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138383003364 catalytic residue [active] 1138383003365 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1138383003366 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1138383003367 MgtE intracellular N domain; Region: MgtE_N; smart00924 1138383003368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1138383003369 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138383003370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138383003371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138383003372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383003373 dimer interface [polypeptide binding]; other site 1138383003374 conserved gate region; other site 1138383003375 putative PBP binding loops; other site 1138383003376 ABC-ATPase subunit interface; other site 1138383003377 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138383003378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383003379 dimer interface [polypeptide binding]; other site 1138383003380 conserved gate region; other site 1138383003381 ABC-ATPase subunit interface; other site 1138383003382 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138383003383 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138383003384 Walker A/P-loop; other site 1138383003385 ATP binding site [chemical binding]; other site 1138383003386 Q-loop/lid; other site 1138383003387 ABC transporter signature motif; other site 1138383003388 Walker B; other site 1138383003389 D-loop; other site 1138383003390 H-loop/switch region; other site 1138383003391 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1138383003392 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1138383003393 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1138383003394 oligomer interface [polypeptide binding]; other site 1138383003395 metal binding site [ion binding]; metal-binding site 1138383003396 metal binding site [ion binding]; metal-binding site 1138383003397 putative Cl binding site [ion binding]; other site 1138383003398 basic sphincter; other site 1138383003399 hydrophobic gate; other site 1138383003400 periplasmic entrance; other site 1138383003401 malate dehydrogenase; Provisional; Region: PRK05442 1138383003402 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1138383003403 NAD(P) binding site [chemical binding]; other site 1138383003404 dimer interface [polypeptide binding]; other site 1138383003405 malate binding site [chemical binding]; other site 1138383003406 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1138383003407 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1138383003408 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1138383003409 putative NAD(P) binding site [chemical binding]; other site 1138383003410 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1138383003411 short chain dehydrogenase; Provisional; Region: PRK07832 1138383003412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003413 NAD(P) binding site [chemical binding]; other site 1138383003414 active site 1138383003415 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138383003416 classical (c) SDRs; Region: SDR_c; cd05233 1138383003417 NAD(P) binding site [chemical binding]; other site 1138383003418 active site 1138383003419 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1138383003420 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138383003421 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1138383003422 TPP-binding site [chemical binding]; other site 1138383003423 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1138383003424 dimer interface [polypeptide binding]; other site 1138383003425 PYR/PP interface [polypeptide binding]; other site 1138383003426 TPP binding site [chemical binding]; other site 1138383003427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383003428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138383003429 putative substrate translocation pore; other site 1138383003430 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1138383003431 RNase_H superfamily; Region: RNase_H_2; pfam13482 1138383003432 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1138383003433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383003434 ATP binding site [chemical binding]; other site 1138383003435 putative Mg++ binding site [ion binding]; other site 1138383003436 AAA domain; Region: AAA_12; pfam13087 1138383003437 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138383003438 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1138383003439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138383003440 ATP binding site [chemical binding]; other site 1138383003441 Mg++ binding site [ion binding]; other site 1138383003442 motif III; other site 1138383003443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383003444 nucleotide binding region [chemical binding]; other site 1138383003445 ATP-binding site [chemical binding]; other site 1138383003446 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1138383003447 putative RNA binding site [nucleotide binding]; other site 1138383003448 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138383003449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383003450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383003452 Cytochrome P450; Region: p450; cl12078 1138383003453 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383003454 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138383003455 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1138383003456 Fe-S cluster binding site [ion binding]; other site 1138383003457 DNA binding site [nucleotide binding] 1138383003458 active site 1138383003459 hypothetical protein; Validated; Region: PRK05868 1138383003460 hypothetical protein; Provisional; Region: PRK07236 1138383003461 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1138383003462 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383003463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138383003464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138383003465 metal binding site [ion binding]; metal-binding site 1138383003466 active site 1138383003467 I-site; other site 1138383003468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138383003469 metal binding site [ion binding]; metal-binding site 1138383003470 active site 1138383003471 I-site; other site 1138383003472 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138383003473 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1138383003474 HIT family signature motif; other site 1138383003475 catalytic residue [active] 1138383003476 amidase; Provisional; Region: PRK12470 1138383003477 Amidase; Region: Amidase; pfam01425 1138383003478 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1138383003479 putative active site [active] 1138383003480 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383003481 cyclase homology domain; Region: CHD; cd07302 1138383003482 nucleotidyl binding site; other site 1138383003483 metal binding site [ion binding]; metal-binding site 1138383003484 dimer interface [polypeptide binding]; other site 1138383003485 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383003486 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383003487 active site 1138383003488 ATP binding site [chemical binding]; other site 1138383003489 substrate binding site [chemical binding]; other site 1138383003490 activation loop (A-loop); other site 1138383003491 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383003492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138383003493 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1138383003494 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138383003495 Walker A/P-loop; other site 1138383003496 ATP binding site [chemical binding]; other site 1138383003497 Q-loop/lid; other site 1138383003498 ABC transporter signature motif; other site 1138383003499 Walker B; other site 1138383003500 D-loop; other site 1138383003501 H-loop/switch region; other site 1138383003502 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138383003503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138383003504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383003505 Walker A/P-loop; other site 1138383003506 ATP binding site [chemical binding]; other site 1138383003507 Q-loop/lid; other site 1138383003508 ABC transporter signature motif; other site 1138383003509 Walker B; other site 1138383003510 D-loop; other site 1138383003511 H-loop/switch region; other site 1138383003512 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138383003513 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138383003514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383003515 catalytic core [active] 1138383003516 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1138383003517 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1138383003518 active site 1138383003519 metal binding site [ion binding]; metal-binding site 1138383003520 DNA binding site [nucleotide binding] 1138383003521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383003522 Walker A/P-loop; other site 1138383003523 ATP binding site [chemical binding]; other site 1138383003524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383003525 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138383003526 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1138383003527 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1138383003528 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138383003529 Walker A/P-loop; other site 1138383003530 ATP binding site [chemical binding]; other site 1138383003531 Q-loop/lid; other site 1138383003532 ABC transporter signature motif; other site 1138383003533 Walker B; other site 1138383003534 D-loop; other site 1138383003535 H-loop/switch region; other site 1138383003536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138383003537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138383003538 Walker A/P-loop; other site 1138383003539 ATP binding site [chemical binding]; other site 1138383003540 Q-loop/lid; other site 1138383003541 ABC transporter signature motif; other site 1138383003542 Walker B; other site 1138383003543 D-loop; other site 1138383003544 H-loop/switch region; other site 1138383003545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138383003546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1138383003547 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1138383003548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383003549 dimer interface [polypeptide binding]; other site 1138383003550 conserved gate region; other site 1138383003551 putative PBP binding loops; other site 1138383003552 ABC-ATPase subunit interface; other site 1138383003553 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1138383003554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383003555 dimer interface [polypeptide binding]; other site 1138383003556 conserved gate region; other site 1138383003557 putative PBP binding loops; other site 1138383003558 ABC-ATPase subunit interface; other site 1138383003559 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1138383003560 active site clefts [active] 1138383003561 zinc binding site [ion binding]; other site 1138383003562 dimer interface [polypeptide binding]; other site 1138383003563 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383003564 CoenzymeA binding site [chemical binding]; other site 1138383003565 subunit interaction site [polypeptide binding]; other site 1138383003566 PHB binding site; other site 1138383003567 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1138383003568 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138383003569 Active Sites [active] 1138383003570 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1138383003571 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1138383003572 CysD dimerization site [polypeptide binding]; other site 1138383003573 G1 box; other site 1138383003574 putative GEF interaction site [polypeptide binding]; other site 1138383003575 GTP/Mg2+ binding site [chemical binding]; other site 1138383003576 Switch I region; other site 1138383003577 G2 box; other site 1138383003578 G3 box; other site 1138383003579 Switch II region; other site 1138383003580 G4 box; other site 1138383003581 G5 box; other site 1138383003582 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1138383003583 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1138383003584 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138383003585 ligand-binding site [chemical binding]; other site 1138383003586 Rrf2 family protein; Region: rrf2_super; TIGR00738 1138383003587 Transcriptional regulator; Region: Rrf2; pfam02082 1138383003588 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 1138383003589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383003590 metal binding site [ion binding]; metal-binding site 1138383003591 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1138383003592 putative dimer interface [polypeptide binding]; other site 1138383003593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383003594 ligand binding site [chemical binding]; other site 1138383003595 Zn binding site [ion binding]; other site 1138383003596 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383003597 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1138383003598 TrkA-N domain; Region: TrkA_N; pfam02254 1138383003599 Ion channel; Region: Ion_trans_2; pfam07885 1138383003600 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138383003601 TrkA-N domain; Region: TrkA_N; pfam02254 1138383003602 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383003603 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1138383003604 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1138383003605 dimer interface [polypeptide binding]; other site 1138383003606 ADP-ribose binding site [chemical binding]; other site 1138383003607 active site 1138383003608 nudix motif; other site 1138383003609 metal binding site [ion binding]; metal-binding site 1138383003610 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1138383003611 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1138383003612 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1138383003613 active site 1138383003614 HIGH motif; other site 1138383003615 KMSK motif region; other site 1138383003616 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1138383003617 tRNA binding surface [nucleotide binding]; other site 1138383003618 anticodon binding site; other site 1138383003619 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1138383003620 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1138383003621 active site 1138383003622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138383003623 substrate binding site [chemical binding]; other site 1138383003624 catalytic residues [active] 1138383003625 dimer interface [polypeptide binding]; other site 1138383003626 homoserine dehydrogenase; Provisional; Region: PRK06349 1138383003627 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1138383003628 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1138383003629 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1138383003630 threonine synthase; Reviewed; Region: PRK06721 1138383003631 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1138383003632 homodimer interface [polypeptide binding]; other site 1138383003633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383003634 catalytic residue [active] 1138383003635 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1138383003636 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1138383003637 transcription termination factor Rho; Provisional; Region: PRK12608 1138383003638 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138383003639 RNA binding site [nucleotide binding]; other site 1138383003640 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1138383003641 multimer interface [polypeptide binding]; other site 1138383003642 Walker A motif; other site 1138383003643 ATP binding site [chemical binding]; other site 1138383003644 Walker B motif; other site 1138383003645 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1138383003646 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1138383003647 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138383003648 RF-1 domain; Region: RF-1; pfam00472 1138383003649 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1138383003650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383003651 S-adenosylmethionine binding site [chemical binding]; other site 1138383003652 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1138383003653 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1138383003654 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1138383003655 Mg++ binding site [ion binding]; other site 1138383003656 putative catalytic motif [active] 1138383003657 substrate binding site [chemical binding]; other site 1138383003658 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1138383003659 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1138383003660 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1138383003661 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1138383003662 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1138383003663 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1138383003664 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138383003665 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1138383003666 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1138383003667 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138383003668 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1138383003669 beta subunit interaction interface [polypeptide binding]; other site 1138383003670 Walker A motif; other site 1138383003671 ATP binding site [chemical binding]; other site 1138383003672 Walker B motif; other site 1138383003673 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138383003674 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1138383003675 core domain interface [polypeptide binding]; other site 1138383003676 delta subunit interface [polypeptide binding]; other site 1138383003677 epsilon subunit interface [polypeptide binding]; other site 1138383003678 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1138383003679 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138383003680 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1138383003681 alpha subunit interaction interface [polypeptide binding]; other site 1138383003682 Walker A motif; other site 1138383003683 ATP binding site [chemical binding]; other site 1138383003684 Walker B motif; other site 1138383003685 inhibitor binding site; inhibition site 1138383003686 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138383003687 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1138383003688 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1138383003689 gamma subunit interface [polypeptide binding]; other site 1138383003690 epsilon subunit interface [polypeptide binding]; other site 1138383003691 LBP interface [polypeptide binding]; other site 1138383003692 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1138383003693 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1138383003694 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1138383003695 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1138383003696 hinge; other site 1138383003697 active site 1138383003698 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383003699 PPE family; Region: PPE; pfam00823 1138383003700 PE family; Region: PE; pfam00934 1138383003701 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383003702 PPE family; Region: PPE; pfam00823 1138383003703 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383003704 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1138383003705 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1138383003706 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138383003707 DNA binding site [nucleotide binding] 1138383003708 active site 1138383003709 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1138383003710 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1138383003711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383003712 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1138383003713 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138383003714 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138383003715 minor groove reading motif; other site 1138383003716 helix-hairpin-helix signature motif; other site 1138383003717 substrate binding pocket [chemical binding]; other site 1138383003718 active site 1138383003719 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138383003720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138383003721 metal binding site [ion binding]; metal-binding site 1138383003722 active site 1138383003723 I-site; other site 1138383003724 HAMP domain; Region: HAMP; pfam00672 1138383003725 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383003726 cyclase homology domain; Region: CHD; cd07302 1138383003727 nucleotidyl binding site; other site 1138383003728 metal binding site [ion binding]; metal-binding site 1138383003729 dimer interface [polypeptide binding]; other site 1138383003730 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1138383003731 hypothetical protein; Provisional; Region: PRK03298 1138383003732 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1138383003733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383003734 dimer interface [polypeptide binding]; other site 1138383003735 substrate binding site [chemical binding]; other site 1138383003736 metal binding site [ion binding]; metal-binding site 1138383003737 putative acyltransferase; Provisional; Region: PRK05790 1138383003738 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383003739 dimer interface [polypeptide binding]; other site 1138383003740 active site 1138383003741 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1138383003742 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1138383003743 glycogen branching enzyme; Provisional; Region: PRK05402 1138383003744 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1138383003745 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1138383003746 active site 1138383003747 catalytic site [active] 1138383003748 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1138383003749 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1138383003750 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138383003751 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1138383003752 active site 1138383003753 homodimer interface [polypeptide binding]; other site 1138383003754 catalytic site [active] 1138383003755 acceptor binding site [chemical binding]; other site 1138383003756 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1138383003757 putative homodimer interface [polypeptide binding]; other site 1138383003758 putative active site pocket [active] 1138383003759 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1138383003760 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1138383003761 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1138383003762 ATP binding site [chemical binding]; other site 1138383003763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138383003764 putative Mg++ binding site [ion binding]; other site 1138383003765 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1138383003766 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1138383003767 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1138383003768 active site 1138383003769 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1138383003770 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1138383003771 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1138383003772 putative active site pocket [active] 1138383003773 cleavage site 1138383003774 Rhomboid family; Region: Rhomboid; pfam01694 1138383003775 glutamate racemase; Provisional; Region: PRK00865 1138383003776 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1138383003777 ribonuclease PH; Reviewed; Region: rph; PRK00173 1138383003778 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1138383003779 hexamer interface [polypeptide binding]; other site 1138383003780 active site 1138383003781 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1138383003782 active site 1138383003783 dimerization interface [polypeptide binding]; other site 1138383003784 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1138383003785 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1138383003786 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1138383003787 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1138383003788 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138383003789 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138383003790 FAD binding pocket [chemical binding]; other site 1138383003791 FAD binding motif [chemical binding]; other site 1138383003792 phosphate binding motif [ion binding]; other site 1138383003793 NAD binding pocket [chemical binding]; other site 1138383003794 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138383003795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383003796 Walker A/P-loop; other site 1138383003797 ATP binding site [chemical binding]; other site 1138383003798 Q-loop/lid; other site 1138383003799 ABC transporter signature motif; other site 1138383003800 Walker B; other site 1138383003801 D-loop; other site 1138383003802 H-loop/switch region; other site 1138383003803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383003804 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138383003805 Walker A/P-loop; other site 1138383003806 ATP binding site [chemical binding]; other site 1138383003807 Q-loop/lid; other site 1138383003808 ABC transporter signature motif; other site 1138383003809 Walker B; other site 1138383003810 D-loop; other site 1138383003811 H-loop/switch region; other site 1138383003812 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383003813 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383003814 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383003815 cyclase homology domain; Region: CHD; cd07302 1138383003816 nucleotidyl binding site; other site 1138383003817 metal binding site [ion binding]; metal-binding site 1138383003818 dimer interface [polypeptide binding]; other site 1138383003819 Predicted ATPase [General function prediction only]; Region: COG3903 1138383003820 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383003821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383003822 DNA binding residues [nucleotide binding] 1138383003823 dimerization interface [polypeptide binding]; other site 1138383003824 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138383003825 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383003826 classical (c) SDRs; Region: SDR_c; cd05233 1138383003827 NAD(P) binding site [chemical binding]; other site 1138383003828 active site 1138383003829 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383003830 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383003831 active site 1138383003832 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383003833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003834 NAD(P) binding site [chemical binding]; other site 1138383003835 active site 1138383003836 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1138383003837 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383003838 dimer interface [polypeptide binding]; other site 1138383003839 active site 1138383003840 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1138383003841 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383003842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383003843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383003844 active site 1138383003845 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138383003846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383003847 DNA-binding site [nucleotide binding]; DNA binding site 1138383003848 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138383003849 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1138383003850 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138383003851 conserved cys residue [active] 1138383003852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383003853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383003854 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138383003855 conserved cys residue [active] 1138383003856 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383003857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003859 acyl-activating enzyme (AAE) consensus motif; other site 1138383003860 acyl-activating enzyme (AAE) consensus motif; other site 1138383003861 AMP binding site [chemical binding]; other site 1138383003862 active site 1138383003863 CoA binding site [chemical binding]; other site 1138383003864 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383003865 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003866 acyl-activating enzyme (AAE) consensus motif; other site 1138383003867 AMP binding site [chemical binding]; other site 1138383003868 active site 1138383003869 CoA binding site [chemical binding]; other site 1138383003870 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383003871 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003872 acyl-activating enzyme (AAE) consensus motif; other site 1138383003873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003874 AMP binding site [chemical binding]; other site 1138383003875 active site 1138383003876 acyl-activating enzyme (AAE) consensus motif; other site 1138383003877 CoA binding site [chemical binding]; other site 1138383003878 enoyl-CoA hydratase; Provisional; Region: PRK05981 1138383003879 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383003880 substrate binding site [chemical binding]; other site 1138383003881 oxyanion hole (OAH) forming residues; other site 1138383003882 trimer interface [polypeptide binding]; other site 1138383003883 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383003884 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383003885 substrate binding site [chemical binding]; other site 1138383003886 oxyanion hole (OAH) forming residues; other site 1138383003887 trimer interface [polypeptide binding]; other site 1138383003888 enoyl-CoA hydratase; Region: PLN02600 1138383003889 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383003890 substrate binding site [chemical binding]; other site 1138383003891 oxyanion hole (OAH) forming residues; other site 1138383003892 trimer interface [polypeptide binding]; other site 1138383003893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383003894 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1138383003895 substrate binding site [chemical binding]; other site 1138383003896 oxyanion hole (OAH) forming residues; other site 1138383003897 trimer interface [polypeptide binding]; other site 1138383003898 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138383003899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003900 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138383003901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003902 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383003903 NAD(P) binding site [chemical binding]; other site 1138383003904 active site 1138383003905 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138383003906 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1138383003907 active site 1138383003908 inhibitor site; inhibition site 1138383003909 dimer interface [polypeptide binding]; other site 1138383003910 catalytic residue [active] 1138383003911 CsbD-like; Region: CsbD; cl17424 1138383003912 enoyl-CoA hydratase; Provisional; Region: PRK06210 1138383003913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383003914 substrate binding site [chemical binding]; other site 1138383003915 oxyanion hole (OAH) forming residues; other site 1138383003916 trimer interface [polypeptide binding]; other site 1138383003917 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383003918 acyl-CoA synthetase; Validated; Region: PRK07798 1138383003919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003920 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138383003921 acyl-activating enzyme (AAE) consensus motif; other site 1138383003922 acyl-activating enzyme (AAE) consensus motif; other site 1138383003923 putative AMP binding site [chemical binding]; other site 1138383003924 putative active site [active] 1138383003925 putative CoA binding site [chemical binding]; other site 1138383003926 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383003927 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138383003928 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383003929 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383003930 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383003931 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383003932 active site 1138383003933 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383003934 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138383003935 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383003936 active site 1138383003937 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383003938 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383003939 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383003940 Cytochrome P450; Region: p450; cl12078 1138383003941 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383003942 NAD(P) binding site [chemical binding]; other site 1138383003943 catalytic residues [active] 1138383003944 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383003945 Cytochrome P450; Region: p450; cl12078 1138383003946 short chain dehydrogenase; Provisional; Region: PRK07832 1138383003947 classical (c) SDRs; Region: SDR_c; cd05233 1138383003948 NAD(P) binding site [chemical binding]; other site 1138383003949 active site 1138383003950 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383003951 hydrophobic ligand binding site; other site 1138383003952 acyl-CoA synthetase; Validated; Region: PRK07798 1138383003953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383003954 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138383003955 acyl-activating enzyme (AAE) consensus motif; other site 1138383003956 acyl-activating enzyme (AAE) consensus motif; other site 1138383003957 putative AMP binding site [chemical binding]; other site 1138383003958 putative active site [active] 1138383003959 putative CoA binding site [chemical binding]; other site 1138383003960 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383003961 CoenzymeA binding site [chemical binding]; other site 1138383003962 subunit interaction site [polypeptide binding]; other site 1138383003963 PHB binding site; other site 1138383003964 Isochorismatase family; Region: Isochorismatase; pfam00857 1138383003965 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138383003966 catalytic triad [active] 1138383003967 conserved cis-peptide bond; other site 1138383003968 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383003969 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383003970 [2Fe-2S] cluster binding site [ion binding]; other site 1138383003971 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383003972 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383003973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383003974 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383003975 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1138383003976 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383003977 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138383003978 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138383003979 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383003980 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383003981 Cytochrome P450; Region: p450; cl12078 1138383003982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383003983 short chain dehydrogenase; Provisional; Region: PRK06197 1138383003984 NAD(P) binding site [chemical binding]; other site 1138383003985 active site 1138383003986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383003987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383003988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383003989 Walker A/P-loop; other site 1138383003990 ATP binding site [chemical binding]; other site 1138383003991 Predicted membrane protein [Function unknown]; Region: COG1511 1138383003992 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1138383003993 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1138383003994 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138383003995 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138383003996 NAD binding site [chemical binding]; other site 1138383003997 catalytic Zn binding site [ion binding]; other site 1138383003998 substrate binding site [chemical binding]; other site 1138383003999 structural Zn binding site [ion binding]; other site 1138383004000 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004001 Cytochrome P450; Region: p450; cl12078 1138383004002 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383004003 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383004004 substrate binding pocket [chemical binding]; other site 1138383004005 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004006 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383004007 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383004008 active site 1138383004009 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004011 active site 1138383004012 PAS fold; Region: PAS_4; pfam08448 1138383004013 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138383004014 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138383004015 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138383004016 ATP binding site [chemical binding]; other site 1138383004017 Mg2+ binding site [ion binding]; other site 1138383004018 G-X-G motif; other site 1138383004019 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383004020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004022 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383004023 CoenzymeA binding site [chemical binding]; other site 1138383004024 subunit interaction site [polypeptide binding]; other site 1138383004025 PHB binding site; other site 1138383004026 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383004027 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383004028 putative AMP binding site [chemical binding]; other site 1138383004029 putative active site [active] 1138383004030 acyl-activating enzyme (AAE) consensus motif; other site 1138383004031 putative CoA binding site [chemical binding]; other site 1138383004032 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1138383004033 active site 1138383004034 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004035 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004036 active site 1138383004037 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004038 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004039 active site 1138383004040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004041 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004042 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383004043 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383004044 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138383004045 classical (c) SDRs; Region: SDR_c; cd05233 1138383004046 NAD(P) binding site [chemical binding]; other site 1138383004047 active site 1138383004048 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138383004049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383004050 DNA-binding site [nucleotide binding]; DNA binding site 1138383004051 FCD domain; Region: FCD; pfam07729 1138383004052 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383004053 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383004054 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383004055 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383004056 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138383004057 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138383004058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004059 Cytochrome P450; Region: p450; cl12078 1138383004060 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383004061 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383004062 [2Fe-2S] cluster binding site [ion binding]; other site 1138383004063 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383004064 hydrophobic ligand binding site; other site 1138383004065 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1138383004066 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1138383004067 acyl-activating enzyme (AAE) consensus motif; other site 1138383004068 putative AMP binding site [chemical binding]; other site 1138383004069 putative active site [active] 1138383004070 putative CoA binding site [chemical binding]; other site 1138383004071 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383004072 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138383004073 active site 1138383004074 catalytic site [active] 1138383004075 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138383004076 putative active site [active] 1138383004077 putative catalytic site [active] 1138383004078 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383004079 TIGR03086 family protein; Region: TIGR03086 1138383004080 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138383004081 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383004082 NAD binding site [chemical binding]; other site 1138383004083 catalytic residues [active] 1138383004084 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1138383004085 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383004086 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383004087 [2Fe-2S] cluster binding site [ion binding]; other site 1138383004088 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1138383004089 putative alpha subunit interface [polypeptide binding]; other site 1138383004090 putative active site [active] 1138383004091 putative substrate binding site [chemical binding]; other site 1138383004092 Fe binding site [ion binding]; other site 1138383004093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383004094 sequence-specific DNA binding site [nucleotide binding]; other site 1138383004095 salt bridge; other site 1138383004096 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1138383004097 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138383004098 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1138383004099 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138383004100 phosphate binding site [ion binding]; other site 1138383004101 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1138383004102 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1138383004103 putative active site [active] 1138383004104 putative catalytic site [active] 1138383004105 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138383004106 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138383004107 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1138383004108 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1138383004109 putative NAD(P) binding site [chemical binding]; other site 1138383004110 active site 1138383004111 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1138383004112 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1138383004113 active site 1138383004114 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1138383004115 hypothetical protein; Provisional; Region: PRK07907 1138383004116 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1138383004117 active site 1138383004118 metal binding site [ion binding]; metal-binding site 1138383004119 dimer interface [polypeptide binding]; other site 1138383004120 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004121 Cytochrome P450; Region: p450; cl12078 1138383004122 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138383004123 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138383004124 catalytic triad [active] 1138383004125 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1138383004126 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138383004127 hypothetical protein; Provisional; Region: PRK01346 1138383004128 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1138383004129 MMPL family; Region: MMPL; pfam03176 1138383004130 MMPL family; Region: MMPL; pfam03176 1138383004131 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138383004132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138383004133 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138383004134 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138383004135 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1138383004136 catalytic site [active] 1138383004137 putative active site [active] 1138383004138 putative substrate binding site [chemical binding]; other site 1138383004139 dimer interface [polypeptide binding]; other site 1138383004140 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1138383004141 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138383004142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004143 NAD(P) binding site [chemical binding]; other site 1138383004144 active site 1138383004145 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1138383004146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383004147 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383004148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004150 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1138383004151 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138383004152 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383004153 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138383004154 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138383004155 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138383004156 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138383004157 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138383004158 carboxyltransferase (CT) interaction site; other site 1138383004159 biotinylation site [posttranslational modification]; other site 1138383004160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004162 active site 1138383004163 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1138383004164 putative active site [active] 1138383004165 putative catalytic site [active] 1138383004166 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138383004167 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1138383004168 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138383004169 tetramer interface [polypeptide binding]; other site 1138383004170 TPP-binding site [chemical binding]; other site 1138383004171 heterodimer interface [polypeptide binding]; other site 1138383004172 phosphorylation loop region [posttranslational modification] 1138383004173 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1138383004174 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1138383004175 alpha subunit interface [polypeptide binding]; other site 1138383004176 TPP binding site [chemical binding]; other site 1138383004177 heterodimer interface [polypeptide binding]; other site 1138383004178 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138383004179 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138383004180 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1138383004181 E3 interaction surface; other site 1138383004182 lipoyl attachment site [posttranslational modification]; other site 1138383004183 e3 binding domain; Region: E3_binding; pfam02817 1138383004184 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138383004185 enoyl-CoA hydratase; Provisional; Region: PRK05870 1138383004186 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004187 substrate binding site [chemical binding]; other site 1138383004188 oxyanion hole (OAH) forming residues; other site 1138383004189 trimer interface [polypeptide binding]; other site 1138383004190 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138383004191 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383004192 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383004193 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383004194 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383004195 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138383004196 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1138383004197 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383004198 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138383004199 putative acyl-acceptor binding pocket; other site 1138383004200 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1138383004201 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138383004202 putative acyl-acceptor binding pocket; other site 1138383004203 Copper resistance protein D; Region: CopD; pfam05425 1138383004204 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1138383004205 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1138383004206 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138383004207 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138383004208 dimer interface [polypeptide binding]; other site 1138383004209 ssDNA binding site [nucleotide binding]; other site 1138383004210 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138383004211 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1138383004212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383004213 Walker A/P-loop; other site 1138383004214 ATP binding site [chemical binding]; other site 1138383004215 Q-loop/lid; other site 1138383004216 ABC transporter signature motif; other site 1138383004217 Walker B; other site 1138383004218 D-loop; other site 1138383004219 H-loop/switch region; other site 1138383004220 ABC transporter; Region: ABC_tran_2; pfam12848 1138383004221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138383004222 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1138383004223 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138383004224 active site 1138383004225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383004226 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138383004227 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1138383004228 active site 1138383004229 catalytic site [active] 1138383004230 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138383004231 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1138383004232 apolar tunnel; other site 1138383004233 heme binding site [chemical binding]; other site 1138383004234 dimerization interface [polypeptide binding]; other site 1138383004235 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1138383004236 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383004237 active site 1138383004238 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1138383004239 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1138383004240 Zn binding site [ion binding]; other site 1138383004241 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138383004242 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1138383004243 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138383004244 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1138383004245 putative DNA binding site [nucleotide binding]; other site 1138383004246 catalytic residue [active] 1138383004247 putative H2TH interface [polypeptide binding]; other site 1138383004248 putative catalytic residues [active] 1138383004249 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138383004250 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138383004251 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383004252 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383004253 trigger factor; Provisional; Region: tig; PRK01490 1138383004254 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1138383004255 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1138383004256 Clp protease; Region: CLP_protease; pfam00574 1138383004257 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138383004258 oligomer interface [polypeptide binding]; other site 1138383004259 active site residues [active] 1138383004260 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1138383004261 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138383004262 oligomer interface [polypeptide binding]; other site 1138383004263 active site residues [active] 1138383004264 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1138383004265 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1138383004266 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1138383004267 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1138383004268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383004269 Walker A motif; other site 1138383004270 ATP binding site [chemical binding]; other site 1138383004271 Walker B motif; other site 1138383004272 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1138383004273 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1138383004274 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1138383004275 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1138383004276 dimer interface [polypeptide binding]; other site 1138383004277 PYR/PP interface [polypeptide binding]; other site 1138383004278 TPP binding site [chemical binding]; other site 1138383004279 substrate binding site [chemical binding]; other site 1138383004280 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1138383004281 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1138383004282 TPP-binding site [chemical binding]; other site 1138383004283 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1138383004284 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1138383004285 GTP binding site; other site 1138383004286 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138383004287 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1138383004288 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1138383004289 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383004290 active site 1138383004291 HIGH motif; other site 1138383004292 nucleotide binding site [chemical binding]; other site 1138383004293 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138383004294 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1138383004295 active site 1138383004296 KMSKS motif; other site 1138383004297 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1138383004298 tRNA binding surface [nucleotide binding]; other site 1138383004299 anticodon binding site; other site 1138383004300 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1138383004301 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1138383004302 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138383004303 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1138383004304 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1138383004305 active site 1138383004306 multimer interface [polypeptide binding]; other site 1138383004307 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1138383004308 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1138383004309 homodimer interface [polypeptide binding]; other site 1138383004310 oligonucleotide binding site [chemical binding]; other site 1138383004311 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1138383004312 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1138383004313 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1138383004314 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1138383004315 GTP1/OBG; Region: GTP1_OBG; pfam01018 1138383004316 Obg GTPase; Region: Obg; cd01898 1138383004317 G1 box; other site 1138383004318 GTP/Mg2+ binding site [chemical binding]; other site 1138383004319 Switch I region; other site 1138383004320 G2 box; other site 1138383004321 G3 box; other site 1138383004322 Switch II region; other site 1138383004323 G4 box; other site 1138383004324 G5 box; other site 1138383004325 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1138383004326 gamma-glutamyl kinase; Provisional; Region: PRK05429 1138383004327 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1138383004328 nucleotide binding site [chemical binding]; other site 1138383004329 homotetrameric interface [polypeptide binding]; other site 1138383004330 putative phosphate binding site [ion binding]; other site 1138383004331 putative allosteric binding site; other site 1138383004332 PUA domain; Region: PUA; pfam01472 1138383004333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004335 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004336 Cytochrome P450; Region: p450; cl12078 1138383004337 NAD-dependent deacetylase; Provisional; Region: PRK00481 1138383004338 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1138383004339 NAD+ binding site [chemical binding]; other site 1138383004340 substrate binding site [chemical binding]; other site 1138383004341 Zn binding site [ion binding]; other site 1138383004342 Isochorismatase family; Region: Isochorismatase; pfam00857 1138383004343 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138383004344 catalytic triad [active] 1138383004345 conserved cis-peptide bond; other site 1138383004346 NAD synthetase; Reviewed; Region: nadE; PRK02628 1138383004347 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1138383004348 multimer interface [polypeptide binding]; other site 1138383004349 active site 1138383004350 catalytic triad [active] 1138383004351 protein interface 1 [polypeptide binding]; other site 1138383004352 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1138383004353 homodimer interface [polypeptide binding]; other site 1138383004354 NAD binding pocket [chemical binding]; other site 1138383004355 ATP binding pocket [chemical binding]; other site 1138383004356 Mg binding site [ion binding]; other site 1138383004357 active-site loop [active] 1138383004358 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1138383004359 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138383004360 substrate binding site [chemical binding]; other site 1138383004361 dimer interface [polypeptide binding]; other site 1138383004362 ATP binding site [chemical binding]; other site 1138383004363 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138383004364 dimerization interface [polypeptide binding]; other site 1138383004365 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138383004366 cyclase homology domain; Region: CHD; cd07302 1138383004367 nucleotidyl binding site; other site 1138383004368 metal binding site [ion binding]; metal-binding site 1138383004369 dimer interface [polypeptide binding]; other site 1138383004370 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138383004371 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138383004372 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138383004373 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138383004374 ligand binding site [chemical binding]; other site 1138383004375 flexible hinge region; other site 1138383004376 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1138383004377 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1138383004378 putative catalytic cysteine [active] 1138383004379 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138383004380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383004381 Walker A motif; other site 1138383004382 ATP binding site [chemical binding]; other site 1138383004383 Walker B motif; other site 1138383004384 arginine finger; other site 1138383004385 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1138383004386 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138383004387 metal ion-dependent adhesion site (MIDAS); other site 1138383004388 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1138383004389 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1138383004390 active site 1138383004391 (T/H)XGH motif; other site 1138383004392 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1138383004393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383004394 catalytic core [active] 1138383004395 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138383004396 active site 1138383004397 catalytic triad [active] 1138383004398 oxyanion hole [active] 1138383004399 EDD domain protein, DegV family; Region: DegV; TIGR00762 1138383004400 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1138383004401 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138383004402 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383004403 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383004404 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 1138383004405 acyl-CoA synthetase; Validated; Region: PRK05850 1138383004406 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138383004407 acyl-activating enzyme (AAE) consensus motif; other site 1138383004408 active site 1138383004409 PE-PPE domain; Region: PE-PPE; pfam08237 1138383004410 Transport protein; Region: actII; TIGR00833 1138383004411 Condensation domain; Region: Condensation; pfam00668 1138383004412 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383004413 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138383004414 active site 1138383004415 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138383004416 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383004417 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138383004418 KR domain; Region: KR; pfam08659 1138383004419 putative NADP binding site [chemical binding]; other site 1138383004420 active site 1138383004421 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383004422 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383004423 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383004424 active site 1138383004425 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383004426 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138383004427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004428 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138383004429 Enoylreductase; Region: PKS_ER; smart00829 1138383004430 NAD(P) binding site [chemical binding]; other site 1138383004431 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138383004432 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383004433 putative NADP binding site [chemical binding]; other site 1138383004434 active site 1138383004435 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383004436 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138383004437 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138383004438 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383004439 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383004440 active site 1138383004441 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138383004442 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138383004443 FAD binding site [chemical binding]; other site 1138383004444 substrate binding site [chemical binding]; other site 1138383004445 catalytic base [active] 1138383004446 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1138383004447 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138383004448 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1138383004449 Competence protein; Region: Competence; pfam03772 1138383004450 hypothetical protein; Reviewed; Region: PRK07914 1138383004451 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1138383004452 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1138383004453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138383004454 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138383004455 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138383004456 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138383004457 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138383004458 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138383004459 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138383004460 DoxX-like family; Region: DoxX_2; pfam13564 1138383004461 ribonuclease Z; Reviewed; Region: PRK00055 1138383004462 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1138383004463 FOG: CBS domain [General function prediction only]; Region: COG0517 1138383004464 PemK-like protein; Region: PemK; pfam02452 1138383004465 GTP-binding protein LepA; Provisional; Region: PRK05433 1138383004466 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1138383004467 putative GEF interaction site [polypeptide binding]; other site 1138383004468 Switch I region; other site 1138383004469 G2 box; other site 1138383004470 G3 box; other site 1138383004471 Switch II region; other site 1138383004472 GTP/Mg2+ binding site [chemical binding]; other site 1138383004473 G4 box; other site 1138383004474 G5 box; other site 1138383004475 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1138383004476 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1138383004477 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1138383004478 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383004479 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383004480 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138383004481 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1138383004482 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138383004483 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1138383004484 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138383004485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383004486 dimer interface [polypeptide binding]; other site 1138383004487 conserved gate region; other site 1138383004488 putative PBP binding loops; other site 1138383004489 ABC-ATPase subunit interface; other site 1138383004490 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138383004491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383004492 dimer interface [polypeptide binding]; other site 1138383004493 conserved gate region; other site 1138383004494 putative PBP binding loops; other site 1138383004495 ABC-ATPase subunit interface; other site 1138383004496 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1138383004497 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1138383004498 Walker A/P-loop; other site 1138383004499 ATP binding site [chemical binding]; other site 1138383004500 Q-loop/lid; other site 1138383004501 ABC transporter signature motif; other site 1138383004502 Walker B; other site 1138383004503 D-loop; other site 1138383004504 H-loop/switch region; other site 1138383004505 TOBE domain; Region: TOBE; pfam03459 1138383004506 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1138383004507 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138383004508 Active Sites [active] 1138383004509 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1138383004510 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138383004511 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138383004512 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1138383004513 HemN C-terminal domain; Region: HemN_C; pfam06969 1138383004514 Predicted permease [General function prediction only]; Region: COG3329 1138383004515 salicylate synthase MbtI; Reviewed; Region: PRK07912 1138383004516 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138383004517 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1138383004518 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383004519 DNA binding residues [nucleotide binding] 1138383004520 putative dimer interface [polypeptide binding]; other site 1138383004521 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383004522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383004523 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1138383004524 classical (c) SDRs; Region: SDR_c; cd05233 1138383004525 NAD(P) binding site [chemical binding]; other site 1138383004526 active site 1138383004527 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138383004528 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138383004529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383004530 S-adenosylmethionine binding site [chemical binding]; other site 1138383004531 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1138383004532 Protein of unknown function DUF262; Region: DUF262; pfam03235 1138383004533 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1138383004534 FIC domain binding interface [polypeptide binding]; other site 1138383004535 Transposase; Region: HTH_Tnp_1; pfam01527 1138383004536 HTH-like domain; Region: HTH_21; pfam13276 1138383004537 Integrase core domain; Region: rve; pfam00665 1138383004538 Integrase core domain; Region: rve_3; pfam13683 1138383004539 putative transposase OrfB; Reviewed; Region: PHA02517 1138383004540 HTH-like domain; Region: HTH_21; pfam13276 1138383004541 Integrase core domain; Region: rve; pfam00665 1138383004542 Integrase core domain; Region: rve_3; cl15866 1138383004543 Transposase; Region: HTH_Tnp_1; cl17663 1138383004544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138383004545 TniQ; Region: TniQ; pfam06527 1138383004546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383004547 sequence-specific DNA binding site [nucleotide binding]; other site 1138383004548 salt bridge; other site 1138383004549 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1138383004550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383004551 Walker A motif; other site 1138383004552 ATP binding site [chemical binding]; other site 1138383004553 Walker B motif; other site 1138383004554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004556 active site 1138383004557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004559 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1138383004560 Subunit I/III interface [polypeptide binding]; other site 1138383004561 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1138383004562 classical (c) SDRs; Region: SDR_c; cd05233 1138383004563 NAD(P) binding site [chemical binding]; other site 1138383004564 active site 1138383004565 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383004566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004567 NAD(P) binding site [chemical binding]; other site 1138383004568 active site 1138383004569 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383004570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004571 substrate binding site [chemical binding]; other site 1138383004572 oxyanion hole (OAH) forming residues; other site 1138383004573 trimer interface [polypeptide binding]; other site 1138383004574 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383004575 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004576 substrate binding site [chemical binding]; other site 1138383004577 oxyanion hole (OAH) forming residues; other site 1138383004578 trimer interface [polypeptide binding]; other site 1138383004579 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383004580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004581 substrate binding site [chemical binding]; other site 1138383004582 oxyanion hole (OAH) forming residues; other site 1138383004583 trimer interface [polypeptide binding]; other site 1138383004584 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1138383004585 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138383004586 iron-sulfur cluster [ion binding]; other site 1138383004587 [2Fe-2S] cluster binding site [ion binding]; other site 1138383004588 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1138383004589 putative alpha subunit interface [polypeptide binding]; other site 1138383004590 putative active site [active] 1138383004591 putative substrate binding site [chemical binding]; other site 1138383004592 Fe binding site [ion binding]; other site 1138383004593 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383004594 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1138383004595 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383004596 dimer interface [polypeptide binding]; other site 1138383004597 active site 1138383004598 hypothetical protein; Provisional; Region: PRK04262 1138383004599 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1138383004600 active site 1138383004601 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383004602 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383004603 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 1138383004604 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383004605 active site 1138383004606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004607 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383004608 NAD(P) binding site [chemical binding]; other site 1138383004609 active site 1138383004610 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383004611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383004612 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138383004613 acyl-activating enzyme (AAE) consensus motif; other site 1138383004614 acyl-activating enzyme (AAE) consensus motif; other site 1138383004615 putative AMP binding site [chemical binding]; other site 1138383004616 putative active site [active] 1138383004617 putative CoA binding site [chemical binding]; other site 1138383004618 AMP-binding enzyme; Region: AMP-binding; pfam00501 1138383004619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383004620 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138383004621 acyl-activating enzyme (AAE) consensus motif; other site 1138383004622 putative AMP binding site [chemical binding]; other site 1138383004623 putative active site [active] 1138383004624 putative CoA binding site [chemical binding]; other site 1138383004625 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138383004626 putative active site [active] 1138383004627 putative catalytic site [active] 1138383004628 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138383004629 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1138383004630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383004631 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138383004632 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383004633 acyl-activating enzyme (AAE) consensus motif; other site 1138383004634 putative AMP binding site [chemical binding]; other site 1138383004635 putative active site [active] 1138383004636 acyl-activating enzyme (AAE) consensus motif; other site 1138383004637 putative CoA binding site [chemical binding]; other site 1138383004638 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004639 Cytochrome P450; Region: p450; cl12078 1138383004640 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1138383004641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004642 NAD(P) binding site [chemical binding]; other site 1138383004643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004644 active site 1138383004645 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1138383004646 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1138383004647 NAD(P) binding site [chemical binding]; other site 1138383004648 catalytic residues [active] 1138383004649 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138383004650 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138383004651 Ferredoxin [Energy production and conversion]; Region: COG1146 1138383004652 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383004653 ferredoxin-NADP+ reductase; Region: PLN02852 1138383004654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383004655 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1138383004656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004658 active site 1138383004659 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138383004660 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383004661 dimer interface [polypeptide binding]; other site 1138383004662 active site 1138383004663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004667 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383004668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004669 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138383004670 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1138383004671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138383004672 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1138383004673 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138383004674 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138383004675 Permease; Region: Permease; pfam02405 1138383004676 Permease; Region: Permease; pfam02405 1138383004677 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383004678 mce related protein; Region: MCE; pfam02470 1138383004679 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383004680 mce related protein; Region: MCE; pfam02470 1138383004681 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383004682 mce related protein; Region: MCE; pfam02470 1138383004683 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383004684 mce related protein; Region: MCE; pfam02470 1138383004685 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383004686 mce related protein; Region: MCE; pfam02470 1138383004687 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383004688 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1138383004689 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1138383004690 Walker A/P-loop; other site 1138383004691 ATP binding site [chemical binding]; other site 1138383004692 Q-loop/lid; other site 1138383004693 ABC transporter signature motif; other site 1138383004694 Walker B; other site 1138383004695 D-loop; other site 1138383004696 H-loop/switch region; other site 1138383004697 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138383004698 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383004699 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383004700 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383004701 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1138383004702 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383004703 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1138383004704 classical (c) SDRs; Region: SDR_c; cd05233 1138383004705 NAD(P) binding site [chemical binding]; other site 1138383004706 active site 1138383004707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004709 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 1138383004710 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383004711 FO synthase; Reviewed; Region: fbiC; PRK09234 1138383004712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383004713 FeS/SAM binding site; other site 1138383004714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383004715 FeS/SAM binding site; other site 1138383004716 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383004717 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138383004718 substrate binding site [chemical binding]; other site 1138383004719 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004720 Cytochrome P450; Region: p450; cl12078 1138383004721 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383004722 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383004723 active site 2 [active] 1138383004724 active site 1 [active] 1138383004725 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383004726 active site 2 [active] 1138383004727 active site 1 [active] 1138383004728 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1138383004729 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 1138383004730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004734 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138383004735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383004736 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383004737 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383004738 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138383004739 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383004740 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383004741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004743 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383004744 Transport protein; Region: actII; TIGR00833 1138383004745 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383004746 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383004747 lipid-transfer protein; Provisional; Region: PRK07855 1138383004748 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383004749 active site 1138383004750 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138383004751 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138383004752 NAD binding site [chemical binding]; other site 1138383004753 catalytic Zn binding site [ion binding]; other site 1138383004754 substrate binding site [chemical binding]; other site 1138383004755 structural Zn binding site [ion binding]; other site 1138383004756 short chain dehydrogenase; Provisional; Region: PRK07775 1138383004757 classical (c) SDRs; Region: SDR_c; cd05233 1138383004758 NAD(P) binding site [chemical binding]; other site 1138383004759 active site 1138383004760 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383004761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004763 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383004764 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138383004765 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138383004766 ligand binding site [chemical binding]; other site 1138383004767 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383004768 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383004769 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004770 Cytochrome P450; Region: p450; cl12078 1138383004771 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383004772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004773 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1138383004774 NAD(P) binding site [chemical binding]; other site 1138383004775 active site 1138383004776 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138383004777 classical (c) SDRs; Region: SDR_c; cd05233 1138383004778 NAD(P) binding site [chemical binding]; other site 1138383004779 active site 1138383004780 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383004781 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383004782 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383004783 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383004784 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1138383004785 short chain dehydrogenase; Provisional; Region: PRK07814 1138383004786 classical (c) SDRs; Region: SDR_c; cd05233 1138383004787 NAD(P) binding site [chemical binding]; other site 1138383004788 active site 1138383004789 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383004790 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383004791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383004792 acyl-activating enzyme (AAE) consensus motif; other site 1138383004793 acyl-activating enzyme (AAE) consensus motif; other site 1138383004794 AMP binding site [chemical binding]; other site 1138383004795 active site 1138383004796 CoA binding site [chemical binding]; other site 1138383004797 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138383004798 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383004799 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383004800 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004801 Cytochrome P450; Region: p450; cl12078 1138383004802 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383004803 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138383004804 NAD(P) binding site [chemical binding]; other site 1138383004805 active site 1138383004806 metal binding site [ion binding]; metal-binding site 1138383004807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1138383004808 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1138383004809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383004810 classical (c) SDRs; Region: SDR_c; cd05233 1138383004811 NAD(P) binding site [chemical binding]; other site 1138383004812 active site 1138383004813 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138383004814 classical (c) SDRs; Region: SDR_c; cd05233 1138383004815 NAD(P) binding site [chemical binding]; other site 1138383004816 active site 1138383004817 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383004818 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383004819 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138383004820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004822 lipid-transfer protein; Provisional; Region: PRK07855 1138383004823 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383004824 active site 1138383004825 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138383004826 putative active site [active] 1138383004827 putative catalytic site [active] 1138383004828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004829 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383004830 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383004831 active site 1138383004832 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138383004833 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383004834 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383004835 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138383004836 active site 1138383004837 catalytic site [active] 1138383004838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004840 active site 1138383004841 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004842 Cytochrome P450; Region: p450; cl12078 1138383004843 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383004844 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383004845 NAD(P) binding site [chemical binding]; other site 1138383004846 catalytic residues [active] 1138383004847 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383004848 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383004849 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383004850 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383004851 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138383004852 putative active site [active] 1138383004853 putative catalytic site [active] 1138383004854 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383004855 Isochorismatase family; Region: Isochorismatase; pfam00857 1138383004856 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138383004857 catalytic triad [active] 1138383004858 conserved cis-peptide bond; other site 1138383004859 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383004860 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383004861 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383004862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004863 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383004864 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383004865 active site 1138383004866 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383004867 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004868 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383004869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004872 active site 1138383004873 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1138383004874 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138383004875 acyl-activating enzyme (AAE) consensus motif; other site 1138383004876 putative AMP binding site [chemical binding]; other site 1138383004877 putative active site [active] 1138383004878 putative CoA binding site [chemical binding]; other site 1138383004879 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383004880 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138383004881 classical (c) SDRs; Region: SDR_c; cd05233 1138383004882 NAD(P) binding site [chemical binding]; other site 1138383004883 active site 1138383004884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383004885 active site 1138383004886 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383004887 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383004888 acyl-activating enzyme (AAE) consensus motif; other site 1138383004889 AMP binding site [chemical binding]; other site 1138383004890 active site 1138383004891 CoA binding site [chemical binding]; other site 1138383004892 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383004893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004894 substrate binding site [chemical binding]; other site 1138383004895 oxyanion hole (OAH) forming residues; other site 1138383004896 trimer interface [polypeptide binding]; other site 1138383004897 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383004898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004899 substrate binding site [chemical binding]; other site 1138383004900 oxyanion hole (OAH) forming residues; other site 1138383004901 trimer interface [polypeptide binding]; other site 1138383004902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004903 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138383004904 active site 1138383004905 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383004906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004907 substrate binding site [chemical binding]; other site 1138383004908 oxyanion hole (OAH) forming residues; other site 1138383004909 trimer interface [polypeptide binding]; other site 1138383004910 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383004911 active site 2 [active] 1138383004912 active site 1 [active] 1138383004913 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383004914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004915 substrate binding site [chemical binding]; other site 1138383004916 oxyanion hole (OAH) forming residues; other site 1138383004917 trimer interface [polypeptide binding]; other site 1138383004918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1138383004919 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1138383004920 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138383004921 NAD binding site [chemical binding]; other site 1138383004922 homodimer interface [polypeptide binding]; other site 1138383004923 active site 1138383004924 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383004925 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383004926 acyl-activating enzyme (AAE) consensus motif; other site 1138383004927 AMP binding site [chemical binding]; other site 1138383004928 active site 1138383004929 CoA binding site [chemical binding]; other site 1138383004930 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383004931 thiolase; Provisional; Region: PRK06158 1138383004932 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383004933 active site 1138383004934 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138383004935 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138383004936 active site 1138383004937 iron coordination sites [ion binding]; other site 1138383004938 substrate binding pocket [chemical binding]; other site 1138383004939 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1138383004940 glycerate dehydrogenase; Provisional; Region: PRK06487 1138383004941 ligand binding site [chemical binding]; other site 1138383004942 NAD binding site [chemical binding]; other site 1138383004943 dimerization interface [polypeptide binding]; other site 1138383004944 catalytic site [active] 1138383004945 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383004946 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004947 substrate binding site [chemical binding]; other site 1138383004948 oxyanion hole (OAH) forming residues; other site 1138383004949 trimer interface [polypeptide binding]; other site 1138383004950 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383004951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383004952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383004953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004954 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004955 active site 1138383004956 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383004957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383004958 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383004959 active site 1138383004960 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383004961 CoenzymeA binding site [chemical binding]; other site 1138383004962 subunit interaction site [polypeptide binding]; other site 1138383004963 PHB binding site; other site 1138383004964 enoyl-CoA hydratase; Provisional; Region: PRK08290 1138383004965 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383004966 substrate binding site [chemical binding]; other site 1138383004967 oxyanion hole (OAH) forming residues; other site 1138383004968 trimer interface [polypeptide binding]; other site 1138383004969 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383004970 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383004971 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138383004972 FMN binding site [chemical binding]; other site 1138383004973 dimer interface [polypeptide binding]; other site 1138383004974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383004975 Cytochrome P450; Region: p450; cl12078 1138383004976 hypothetical protein; Provisional; Region: PRK07877 1138383004977 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383004978 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383004979 Cupin domain; Region: Cupin_2; cl17218 1138383004980 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1138383004981 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138383004982 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138383004983 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1138383004984 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1138383004985 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138383004986 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383004987 OsmC-like protein; Region: OsmC; cl00767 1138383004988 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138383004989 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1138383004990 active site pocket [active] 1138383004991 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138383004992 aconitate hydratase; Validated; Region: PRK09277 1138383004993 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138383004994 substrate binding site [chemical binding]; other site 1138383004995 ligand binding site [chemical binding]; other site 1138383004996 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1138383004997 substrate binding site [chemical binding]; other site 1138383004998 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138383004999 FMN binding site [chemical binding]; other site 1138383005000 dimer interface [polypeptide binding]; other site 1138383005001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383005002 putative DNA binding site [nucleotide binding]; other site 1138383005003 dimerization interface [polypeptide binding]; other site 1138383005004 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138383005005 putative Zn2+ binding site [ion binding]; other site 1138383005006 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1138383005007 heme-binding site [chemical binding]; other site 1138383005008 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1138383005009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383005010 catalytic loop [active] 1138383005011 iron binding site [ion binding]; other site 1138383005012 Cupin domain; Region: Cupin_2; cl17218 1138383005013 Ferredoxin [Energy production and conversion]; Region: COG1146 1138383005014 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383005015 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138383005016 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138383005017 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138383005018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383005019 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138383005020 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138383005021 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1138383005022 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138383005023 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138383005024 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138383005025 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138383005026 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138383005027 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1138383005028 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1138383005029 Binuclear center (active site) [active] 1138383005030 K-pathway; other site 1138383005031 Putative proton exit pathway; other site 1138383005032 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1138383005033 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383005034 PPE family; Region: PPE; pfam00823 1138383005035 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383005036 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138383005037 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138383005038 Condensation domain; Region: Condensation; pfam00668 1138383005039 malate dehydrogenase; Provisional; Region: PRK13529 1138383005040 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1138383005041 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1138383005042 NAD(P) binding site [chemical binding]; other site 1138383005043 Flavodoxin; Region: Flavodoxin_1; pfam00258 1138383005044 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1138383005045 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1138383005046 FAD binding pocket [chemical binding]; other site 1138383005047 FAD binding motif [chemical binding]; other site 1138383005048 catalytic residues [active] 1138383005049 NAD binding pocket [chemical binding]; other site 1138383005050 phosphate binding motif [ion binding]; other site 1138383005051 beta-alpha-beta structure motif; other site 1138383005052 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383005053 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383005054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005056 Cupin domain; Region: Cupin_2; cl17218 1138383005057 short chain dehydrogenase; Provisional; Region: PRK07577 1138383005058 classical (c) SDRs; Region: SDR_c; cd05233 1138383005059 NAD(P) binding site [chemical binding]; other site 1138383005060 active site 1138383005061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383005062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383005063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138383005064 dimerization interface [polypeptide binding]; other site 1138383005065 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1138383005066 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1138383005067 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1138383005068 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1138383005069 acyl-activating enzyme (AAE) consensus motif; other site 1138383005070 active site 1138383005071 AMP binding site [chemical binding]; other site 1138383005072 substrate binding site [chemical binding]; other site 1138383005073 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1138383005074 Condensation domain; Region: Condensation; pfam00668 1138383005075 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383005076 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1138383005077 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1138383005078 acyl-activating enzyme (AAE) consensus motif; other site 1138383005079 AMP binding site [chemical binding]; other site 1138383005080 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383005081 Thioesterase domain; Region: Thioesterase; pfam00975 1138383005082 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383005083 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138383005084 active site 1138383005085 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138383005086 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383005087 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1138383005088 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383005089 NADP binding site [chemical binding]; other site 1138383005090 active site 1138383005091 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383005092 Condensation domain; Region: Condensation; pfam00668 1138383005093 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383005094 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383005095 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383005096 acyl-activating enzyme (AAE) consensus motif; other site 1138383005097 AMP binding site [chemical binding]; other site 1138383005098 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383005099 Condensation domain; Region: Condensation; pfam00668 1138383005100 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383005101 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383005102 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383005103 acyl-activating enzyme (AAE) consensus motif; other site 1138383005104 AMP binding site [chemical binding]; other site 1138383005105 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383005106 Condensation domain; Region: Condensation; pfam00668 1138383005107 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383005108 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383005109 acyl-activating enzyme (AAE) consensus motif; other site 1138383005110 AMP binding site [chemical binding]; other site 1138383005111 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383005112 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1138383005113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383005114 MbtH-like protein; Region: MbtH; pfam03621 1138383005115 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1138383005116 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138383005117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383005118 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383005119 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383005120 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138383005121 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1138383005122 HTH domain; Region: HTH_11; cl17392 1138383005123 chaperone protein DnaJ; Provisional; Region: PRK14278 1138383005124 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138383005125 HSP70 interaction site [polypeptide binding]; other site 1138383005126 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138383005127 Zn binding sites [ion binding]; other site 1138383005128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138383005129 dimer interface [polypeptide binding]; other site 1138383005130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1138383005131 RNA methyltransferase, RsmE family; Region: TIGR00046 1138383005132 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1138383005133 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1138383005134 PhoH-like protein; Region: PhoH; pfam02562 1138383005135 metal-binding heat shock protein; Provisional; Region: PRK00016 1138383005136 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138383005137 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138383005138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138383005139 Transporter associated domain; Region: CorC_HlyC; smart01091 1138383005140 GTPase Era; Reviewed; Region: era; PRK00089 1138383005141 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1138383005142 G1 box; other site 1138383005143 GTP/Mg2+ binding site [chemical binding]; other site 1138383005144 Switch I region; other site 1138383005145 G2 box; other site 1138383005146 Switch II region; other site 1138383005147 G3 box; other site 1138383005148 G4 box; other site 1138383005149 G5 box; other site 1138383005150 KH domain; Region: KH_2; pfam07650 1138383005151 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1138383005152 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383005153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383005154 catalytic residue [active] 1138383005155 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1138383005156 amidase; Provisional; Region: PRK06061 1138383005157 Amidase; Region: Amidase; pfam01425 1138383005158 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1138383005159 Recombination protein O N terminal; Region: RecO_N; pfam11967 1138383005160 Recombination protein O C terminal; Region: RecO_C; pfam02565 1138383005161 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138383005162 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138383005163 catalytic residue [active] 1138383005164 putative FPP diphosphate binding site; other site 1138383005165 putative FPP binding hydrophobic cleft; other site 1138383005166 dimer interface [polypeptide binding]; other site 1138383005167 putative IPP diphosphate binding site; other site 1138383005168 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138383005169 metal binding site 2 [ion binding]; metal-binding site 1138383005170 putative DNA binding helix; other site 1138383005171 metal binding site 1 [ion binding]; metal-binding site 1138383005172 dimer interface [polypeptide binding]; other site 1138383005173 structural Zn2+ binding site [ion binding]; other site 1138383005174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383005175 dimerization interface [polypeptide binding]; other site 1138383005176 putative DNA binding site [nucleotide binding]; other site 1138383005177 putative Zn2+ binding site [ion binding]; other site 1138383005178 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1138383005179 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138383005180 motif 1; other site 1138383005181 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1138383005182 active site 1138383005183 motif 2; other site 1138383005184 motif 3; other site 1138383005185 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1138383005186 anticodon binding site; other site 1138383005187 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383005188 PPE family; Region: PPE; pfam00823 1138383005189 Repair protein; Region: Repair_PSII; pfam04536 1138383005190 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1138383005191 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1138383005192 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1138383005193 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1138383005194 E-class dimer interface [polypeptide binding]; other site 1138383005195 P-class dimer interface [polypeptide binding]; other site 1138383005196 active site 1138383005197 Cu2+ binding site [ion binding]; other site 1138383005198 Zn2+ binding site [ion binding]; other site 1138383005199 DNA primase; Validated; Region: dnaG; PRK05667 1138383005200 CHC2 zinc finger; Region: zf-CHC2; cl17510 1138383005201 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1138383005202 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1138383005203 active site 1138383005204 metal binding site [ion binding]; metal-binding site 1138383005205 interdomain interaction site; other site 1138383005206 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1138383005207 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1138383005208 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138383005209 active site 1138383005210 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138383005211 non-prolyl cis peptide bond; other site 1138383005212 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1138383005213 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138383005214 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383005215 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1138383005216 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1138383005217 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1138383005218 trimer interface [polypeptide binding]; other site 1138383005219 active site 1138383005220 substrate binding site [chemical binding]; other site 1138383005221 CoA binding site [chemical binding]; other site 1138383005222 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138383005223 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138383005224 dimer interface [polypeptide binding]; other site 1138383005225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383005226 catalytic residue [active] 1138383005227 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1138383005228 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1138383005229 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383005230 Permease; Region: Permease; pfam02405 1138383005231 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383005232 Permease; Region: Permease; pfam02405 1138383005233 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005234 mce related protein; Region: MCE; pfam02470 1138383005235 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383005236 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005237 mce related protein; Region: MCE; pfam02470 1138383005238 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005239 mce related protein; Region: MCE; pfam02470 1138383005240 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005241 mce related protein; Region: MCE; pfam02470 1138383005242 mce related protein; Region: MCE; pfam02470 1138383005243 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383005244 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005245 mce related protein; Region: MCE; pfam02470 1138383005246 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1138383005247 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1138383005248 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1138383005249 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1138383005250 [4Fe-4S] binding site [ion binding]; other site 1138383005251 molybdopterin cofactor binding site; other site 1138383005252 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1138383005253 molybdopterin cofactor binding site; other site 1138383005254 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1138383005255 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1138383005256 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1138383005257 FAD binding pocket [chemical binding]; other site 1138383005258 FAD binding motif [chemical binding]; other site 1138383005259 catalytic residues [active] 1138383005260 NAD binding pocket [chemical binding]; other site 1138383005261 phosphate binding motif [ion binding]; other site 1138383005262 beta-alpha-beta structure motif; other site 1138383005263 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138383005264 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383005265 active site 1138383005266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383005267 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138383005268 Walker A/P-loop; other site 1138383005269 ATP binding site [chemical binding]; other site 1138383005270 Q-loop/lid; other site 1138383005271 ABC transporter signature motif; other site 1138383005272 Walker B; other site 1138383005273 D-loop; other site 1138383005274 H-loop/switch region; other site 1138383005275 MarR family; Region: MarR; pfam01047 1138383005276 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383005277 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 1138383005278 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138383005279 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1138383005280 Walker A/P-loop; other site 1138383005281 ATP binding site [chemical binding]; other site 1138383005282 Q-loop/lid; other site 1138383005283 ABC transporter signature motif; other site 1138383005284 Walker B; other site 1138383005285 D-loop; other site 1138383005286 H-loop/switch region; other site 1138383005287 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138383005288 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138383005289 Walker A/P-loop; other site 1138383005290 ATP binding site [chemical binding]; other site 1138383005291 Q-loop/lid; other site 1138383005292 ABC transporter signature motif; other site 1138383005293 Walker B; other site 1138383005294 D-loop; other site 1138383005295 H-loop/switch region; other site 1138383005296 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1138383005297 amino acid transporter; Region: 2A0306; TIGR00909 1138383005298 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138383005299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138383005300 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138383005301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138383005302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383005303 dimer interface [polypeptide binding]; other site 1138383005304 conserved gate region; other site 1138383005305 putative PBP binding loops; other site 1138383005306 ABC-ATPase subunit interface; other site 1138383005307 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1138383005308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383005309 dimer interface [polypeptide binding]; other site 1138383005310 conserved gate region; other site 1138383005311 putative PBP binding loops; other site 1138383005312 ABC-ATPase subunit interface; other site 1138383005313 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138383005314 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138383005315 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383005316 Transposase; Region: HTH_Tnp_1; cl17663 1138383005317 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383005318 putative transposase OrfB; Reviewed; Region: PHA02517 1138383005319 HTH-like domain; Region: HTH_21; pfam13276 1138383005320 Integrase core domain; Region: rve; pfam00665 1138383005321 Integrase core domain; Region: rve_3; pfam13683 1138383005322 Transposase; Region: HTH_Tnp_1; cl17663 1138383005323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138383005324 putative transposase OrfB; Reviewed; Region: PHA02517 1138383005325 HTH-like domain; Region: HTH_21; pfam13276 1138383005326 Integrase core domain; Region: rve; pfam00665 1138383005327 Integrase core domain; Region: rve_3; cl15866 1138383005328 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138383005329 DNA binding site [nucleotide binding] 1138383005330 active site 1138383005331 Int/Topo IB signature motif; other site 1138383005332 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383005333 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383005334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383005335 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138383005336 catalytic site [active] 1138383005337 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1138383005338 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138383005339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383005340 ABC transporter signature motif; other site 1138383005341 Walker B; other site 1138383005342 D-loop; other site 1138383005343 H-loop/switch region; other site 1138383005344 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1138383005345 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383005346 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383005347 NAD(P) binding site [chemical binding]; other site 1138383005348 catalytic residues [active] 1138383005349 Repair protein; Region: Repair_PSII; pfam04536 1138383005350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1138383005351 AAA domain; Region: AAA_33; pfam13671 1138383005352 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1138383005353 active site 1138383005354 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1138383005355 catalytic triad [active] 1138383005356 active site nucleophile [active] 1138383005357 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1138383005358 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1138383005359 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383005360 cyclase homology domain; Region: CHD; cd07302 1138383005361 nucleotidyl binding site; other site 1138383005362 metal binding site [ion binding]; metal-binding site 1138383005363 dimer interface [polypeptide binding]; other site 1138383005364 AAA ATPase domain; Region: AAA_16; pfam13191 1138383005365 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138383005366 GAF domain; Region: GAF; pfam01590 1138383005367 GAF domain; Region: GAF_3; pfam13492 1138383005368 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138383005369 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138383005370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138383005371 ATP binding site [chemical binding]; other site 1138383005372 Mg2+ binding site [ion binding]; other site 1138383005373 G-X-G motif; other site 1138383005374 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383005375 anti sigma factor interaction site; other site 1138383005376 regulatory phosphorylation site [posttranslational modification]; other site 1138383005377 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1138383005378 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383005379 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383005380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383005381 S-adenosylmethionine binding site [chemical binding]; other site 1138383005382 CCC1-related family of proteins; Region: CCC1_like; cl00278 1138383005383 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383005384 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138383005385 active site 2 [active] 1138383005386 active site 1 [active] 1138383005387 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383005388 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138383005389 acyl-activating enzyme (AAE) consensus motif; other site 1138383005390 putative AMP binding site [chemical binding]; other site 1138383005391 putative active site [active] 1138383005392 putative CoA binding site [chemical binding]; other site 1138383005393 TIGR03085 family protein; Region: TIGR03085 1138383005394 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383005395 heat shock protein 90; Provisional; Region: PRK05218 1138383005396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383005397 ATP binding site [chemical binding]; other site 1138383005398 Mg2+ binding site [ion binding]; other site 1138383005399 G-X-G motif; other site 1138383005400 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383005401 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383005402 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383005403 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1138383005404 dimer interface [polypeptide binding]; other site 1138383005405 ligand binding site [chemical binding]; other site 1138383005406 Predicted membrane protein [Function unknown]; Region: COG4270 1138383005407 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138383005408 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138383005409 NAD binding site [chemical binding]; other site 1138383005410 catalytic Zn binding site [ion binding]; other site 1138383005411 substrate binding site [chemical binding]; other site 1138383005412 structural Zn binding site [ion binding]; other site 1138383005413 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383005414 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1138383005415 dimer interface [polypeptide binding]; other site 1138383005416 active site 1138383005417 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138383005418 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138383005419 active site 1138383005420 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138383005421 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138383005422 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138383005423 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138383005424 DoxX-like family; Region: DoxX_2; pfam13564 1138383005425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383005426 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138383005427 NAD(P) binding site [chemical binding]; other site 1138383005428 active site 1138383005429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1138383005430 MarR family; Region: MarR; pfam01047 1138383005431 haloalkane dehalogenase; Provisional; Region: PRK00870 1138383005432 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1138383005433 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1138383005434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383005435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383005436 homodimer interface [polypeptide binding]; other site 1138383005437 catalytic residue [active] 1138383005438 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383005439 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383005440 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383005441 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383005442 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138383005443 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138383005444 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138383005445 ligand binding site [chemical binding]; other site 1138383005446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005448 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383005449 Cytochrome P450; Region: p450; cl12078 1138383005450 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383005451 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383005452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383005453 dimerization interface [polypeptide binding]; other site 1138383005454 putative DNA binding site [nucleotide binding]; other site 1138383005455 putative Zn2+ binding site [ion binding]; other site 1138383005456 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1138383005457 arsenical-resistance protein; Region: acr3; TIGR00832 1138383005458 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1138383005459 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138383005460 active site 1138383005461 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1138383005462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383005463 putative metal binding site [ion binding]; other site 1138383005464 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383005465 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138383005466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005467 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138383005468 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383005469 Cytochrome P450; Region: p450; cl12078 1138383005470 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138383005471 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138383005472 active site residue [active] 1138383005473 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138383005474 active site residue [active] 1138383005475 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383005476 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138383005477 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138383005478 hypothetical protein; Provisional; Region: PRK08244 1138383005479 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383005480 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383005481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005482 Predicted ATPase [General function prediction only]; Region: COG4637 1138383005483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383005484 Walker A/P-loop; other site 1138383005485 ATP binding site [chemical binding]; other site 1138383005486 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1138383005487 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1138383005488 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138383005489 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383005490 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383005491 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1138383005492 4Fe-4S binding domain; Region: Fer4; cl02805 1138383005493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383005494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383005495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1138383005496 dimerization interface [polypeptide binding]; other site 1138383005497 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138383005498 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138383005499 putative active site [active] 1138383005500 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1138383005501 putative active site [active] 1138383005502 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1138383005503 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138383005504 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138383005505 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383005506 Cytochrome P450; Region: p450; cl12078 1138383005507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005511 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138383005512 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383005513 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138383005514 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383005515 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138383005516 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383005517 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383005518 active site 1138383005519 ATP binding site [chemical binding]; other site 1138383005520 substrate binding site [chemical binding]; other site 1138383005521 activation loop (A-loop); other site 1138383005522 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138383005523 2TM domain; Region: 2TM; pfam13239 1138383005524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005526 WHG domain; Region: WHG; pfam13305 1138383005527 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383005528 Cytochrome P450; Region: p450; cl12078 1138383005529 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383005530 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383005531 active site 1138383005532 metal binding site [ion binding]; metal-binding site 1138383005533 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 1138383005534 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383005535 FeS/SAM binding site; other site 1138383005536 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 1138383005537 HNH endonuclease; Region: HNH_2; pfam13391 1138383005538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383005539 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383005540 active site 1138383005541 ATP binding site [chemical binding]; other site 1138383005542 substrate binding site [chemical binding]; other site 1138383005543 activation loop (A-loop); other site 1138383005544 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005545 mce related protein; Region: MCE; pfam02470 1138383005546 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005547 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383005548 mce related protein; Region: MCE; pfam02470 1138383005549 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005550 mce related protein; Region: MCE; pfam02470 1138383005551 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383005552 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005553 mce related protein; Region: MCE; pfam02470 1138383005554 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383005555 mce related protein; Region: MCE; pfam02470 1138383005556 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383005557 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1138383005558 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383005559 acyl-activating enzyme (AAE) consensus motif; other site 1138383005560 AMP binding site [chemical binding]; other site 1138383005561 active site 1138383005562 CoA binding site [chemical binding]; other site 1138383005563 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383005564 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138383005565 NAD binding site [chemical binding]; other site 1138383005566 catalytic residues [active] 1138383005567 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383005568 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138383005569 classical (c) SDRs; Region: SDR_c; cd05233 1138383005570 NAD(P) binding site [chemical binding]; other site 1138383005571 active site 1138383005572 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383005573 Cytochrome P450; Region: p450; cl12078 1138383005574 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383005575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005577 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383005578 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383005579 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383005580 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383005581 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383005582 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383005583 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138383005584 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383005585 active site 1138383005586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005588 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383005589 Cytochrome P450; Region: p450; cl12078 1138383005590 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383005591 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383005592 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383005593 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383005594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383005597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383005598 active site 1138383005599 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138383005600 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138383005601 active site 1138383005602 metal binding site [ion binding]; metal-binding site 1138383005603 Cutinase; Region: Cutinase; pfam01083 1138383005604 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383005605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383005606 Septum formation; Region: Septum_form; pfam13845 1138383005607 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383005608 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383005609 Cytochrome P450; Region: p450; cl12078 1138383005610 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383005611 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383005612 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383005613 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383005614 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1138383005615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383005616 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1138383005617 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138383005618 NAD binding site [chemical binding]; other site 1138383005619 catalytic Zn binding site [ion binding]; other site 1138383005620 substrate binding site [chemical binding]; other site 1138383005621 structural Zn binding site [ion binding]; other site 1138383005622 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383005623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383005624 S-adenosylmethionine binding site [chemical binding]; other site 1138383005625 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383005626 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383005627 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1138383005628 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383005629 diacylglycerol kinase; Reviewed; Region: PRK11914 1138383005630 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138383005631 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138383005632 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383005633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005635 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1138383005636 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138383005637 nucleoside/Zn binding site; other site 1138383005638 dimer interface [polypeptide binding]; other site 1138383005639 catalytic motif [active] 1138383005640 FAD binding domain; Region: FAD_binding_3; pfam01494 1138383005641 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138383005642 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138383005643 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383005644 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138383005645 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138383005646 dimer interface [polypeptide binding]; other site 1138383005647 active site 1138383005648 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138383005649 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138383005650 dimer interface [polypeptide binding]; other site 1138383005651 active site 1138383005652 acyl carrier protein; Provisional; Region: acpP; PRK00982 1138383005653 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138383005654 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138383005655 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138383005656 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138383005657 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1138383005658 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1138383005659 dimer interface [polypeptide binding]; other site 1138383005660 TPP-binding site [chemical binding]; other site 1138383005661 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1138383005662 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138383005663 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1138383005664 dimer interface [polypeptide binding]; other site 1138383005665 catalytic triad [active] 1138383005666 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1138383005667 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1138383005668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383005669 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138383005670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383005671 active site 1138383005672 metal binding site [ion binding]; metal-binding site 1138383005673 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1138383005674 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1138383005675 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138383005676 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1138383005677 active site 1138383005678 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1138383005679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383005680 motif II; other site 1138383005681 hypothetical protein; Provisional; Region: PRK07908 1138383005682 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383005683 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383005684 catalytic residue [active] 1138383005685 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1138383005686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1138383005687 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1138383005688 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1138383005689 Putative zinc ribbon domain; Region: DUF164; pfam02591 1138383005690 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1138383005691 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1138383005692 active site 1138383005693 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138383005694 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383005695 catalytic core [active] 1138383005696 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1138383005697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383005698 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138383005699 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383005700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383005701 sequence-specific DNA binding site [nucleotide binding]; other site 1138383005702 salt bridge; other site 1138383005703 Cupin domain; Region: Cupin_2; pfam07883 1138383005704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383005705 S-adenosylmethionine binding site [chemical binding]; other site 1138383005706 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1138383005707 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1138383005708 putative active site; other site 1138383005709 putative metal binding residues [ion binding]; other site 1138383005710 signature motif; other site 1138383005711 putative triphosphate binding site [ion binding]; other site 1138383005712 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1138383005713 hypothetical protein; Provisional; Region: PRK06185 1138383005714 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1138383005715 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1138383005716 oligomerization interface [polypeptide binding]; other site 1138383005717 active site 1138383005718 metal binding site [ion binding]; metal-binding site 1138383005719 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138383005720 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138383005721 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138383005722 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138383005723 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138383005724 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138383005725 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138383005726 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1138383005727 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138383005728 metal binding triad; other site 1138383005729 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138383005730 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138383005731 metal binding triad; other site 1138383005732 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138383005733 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383005734 CoenzymeA binding site [chemical binding]; other site 1138383005735 subunit interaction site [polypeptide binding]; other site 1138383005736 PHB binding site; other site 1138383005737 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383005738 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383005739 MarR family; Region: MarR_2; pfam12802 1138383005740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383005741 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138383005742 NAD(P) binding site [chemical binding]; other site 1138383005743 active site 1138383005744 glutamine synthetase, type I; Region: GlnA; TIGR00653 1138383005745 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138383005746 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138383005747 RDD family; Region: RDD; pfam06271 1138383005748 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1138383005749 lipoyl synthase; Provisional; Region: PRK05481 1138383005750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383005751 FeS/SAM binding site; other site 1138383005752 lipoate-protein ligase B; Provisional; Region: PRK14345 1138383005753 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1138383005754 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1138383005755 putative NAD(P) binding site [chemical binding]; other site 1138383005756 putative active site [active] 1138383005757 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138383005758 E3 interaction surface; other site 1138383005759 lipoyl attachment site [posttranslational modification]; other site 1138383005760 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138383005761 E3 interaction surface; other site 1138383005762 lipoyl attachment site [posttranslational modification]; other site 1138383005763 e3 binding domain; Region: E3_binding; pfam02817 1138383005764 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1138383005765 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138383005766 short chain dehydrogenase; Validated; Region: PRK05855 1138383005767 classical (c) SDRs; Region: SDR_c; cd05233 1138383005768 NAD(P) binding site [chemical binding]; other site 1138383005769 active site 1138383005770 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383005771 hydrophobic ligand binding site; other site 1138383005772 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138383005773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383005774 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1138383005775 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1138383005776 interface (dimer of trimers) [polypeptide binding]; other site 1138383005777 Substrate-binding/catalytic site; other site 1138383005778 Zn-binding sites [ion binding]; other site 1138383005779 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1138383005780 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1138383005781 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1138383005782 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1138383005783 homodimer interface [polypeptide binding]; other site 1138383005784 substrate-cofactor binding pocket; other site 1138383005785 catalytic residue [active] 1138383005786 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1138383005787 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1138383005788 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1138383005789 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1138383005790 putative dimer interface [polypeptide binding]; other site 1138383005791 active site pocket [active] 1138383005792 putative cataytic base [active] 1138383005793 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1138383005794 homotrimer interface [polypeptide binding]; other site 1138383005795 Walker A motif; other site 1138383005796 GTP binding site [chemical binding]; other site 1138383005797 Walker B motif; other site 1138383005798 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1138383005799 Glycerate kinase family; Region: Gly_kinase; pfam02595 1138383005800 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1138383005801 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1138383005802 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138383005803 substrate binding site [chemical binding]; other site 1138383005804 ATP binding site [chemical binding]; other site 1138383005805 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1138383005806 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1138383005807 active site 1138383005808 dimer interface [polypeptide binding]; other site 1138383005809 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1138383005810 Ligand Binding Site [chemical binding]; other site 1138383005811 Molecular Tunnel; other site 1138383005812 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1138383005813 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1138383005814 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1138383005815 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383005816 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1138383005817 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1138383005818 heme bH binding site [chemical binding]; other site 1138383005819 intrachain domain interface; other site 1138383005820 heme bL binding site [chemical binding]; other site 1138383005821 interchain domain interface [polypeptide binding]; other site 1138383005822 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1138383005823 Qo binding site; other site 1138383005824 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1138383005825 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138383005826 iron-sulfur cluster [ion binding]; other site 1138383005827 [2Fe-2S] cluster binding site [ion binding]; other site 1138383005828 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1138383005829 Cytochrome c; Region: Cytochrom_C; pfam00034 1138383005830 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1138383005831 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1138383005832 Subunit I/III interface [polypeptide binding]; other site 1138383005833 hypothetical protein; Validated; Region: PRK07883 1138383005834 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138383005835 active site 1138383005836 catalytic site [active] 1138383005837 substrate binding site [chemical binding]; other site 1138383005838 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138383005839 GIY-YIG motif/motif A; other site 1138383005840 active site 1138383005841 catalytic site [active] 1138383005842 putative DNA binding site [nucleotide binding]; other site 1138383005843 metal binding site [ion binding]; metal-binding site 1138383005844 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138383005845 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138383005846 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1138383005847 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383005848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383005849 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138383005850 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138383005851 acyl-activating enzyme (AAE) consensus motif; other site 1138383005852 putative AMP binding site [chemical binding]; other site 1138383005853 putative active site [active] 1138383005854 putative CoA binding site [chemical binding]; other site 1138383005855 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138383005856 putative hydrophobic ligand binding site [chemical binding]; other site 1138383005857 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138383005858 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138383005859 DTAP/Switch II; other site 1138383005860 Switch I; other site 1138383005861 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383005862 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138383005863 putative acyl-acceptor binding pocket; other site 1138383005864 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138383005865 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1138383005866 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383005867 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383005868 active site 1138383005869 ATP binding site [chemical binding]; other site 1138383005870 substrate binding site [chemical binding]; other site 1138383005871 activation loop (A-loop); other site 1138383005872 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138383005873 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138383005874 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138383005875 substrate binding pocket [chemical binding]; other site 1138383005876 chain length determination region; other site 1138383005877 substrate-Mg2+ binding site; other site 1138383005878 catalytic residues [active] 1138383005879 aspartate-rich region 1; other site 1138383005880 active site lid residues [active] 1138383005881 aspartate-rich region 2; other site 1138383005882 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1138383005883 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1138383005884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1138383005885 MraZ protein; Region: MraZ; pfam02381 1138383005886 MraZ protein; Region: MraZ; pfam02381 1138383005887 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1138383005888 MraW methylase family; Region: Methyltransf_5; cl17771 1138383005889 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138383005890 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1138383005891 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138383005892 hypothetical protein; Provisional; Region: PRK07236 1138383005893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383005894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383005895 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1138383005896 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138383005897 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138383005898 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138383005899 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1138383005900 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138383005901 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138383005902 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1138383005903 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1138383005904 Mg++ binding site [ion binding]; other site 1138383005905 putative catalytic motif [active] 1138383005906 putative substrate binding site [chemical binding]; other site 1138383005907 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1138383005908 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138383005909 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138383005910 cell division protein FtsW; Region: ftsW; TIGR02614 1138383005911 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1138383005912 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1138383005913 active site 1138383005914 homodimer interface [polypeptide binding]; other site 1138383005915 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1138383005916 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138383005917 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138383005918 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138383005919 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1138383005920 Cell division protein FtsQ; Region: FtsQ; pfam03799 1138383005921 cell division protein FtsZ; Validated; Region: PRK09330 1138383005922 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1138383005923 nucleotide binding site [chemical binding]; other site 1138383005924 SulA interaction site; other site 1138383005925 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1138383005926 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1138383005927 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1138383005928 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138383005929 catalytic residue [active] 1138383005930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1138383005931 Predicted integral membrane protein [Function unknown]; Region: COG0762 1138383005932 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138383005933 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138383005934 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138383005935 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383005936 active site 1138383005937 hypothetical protein; Provisional; Region: PRK07906 1138383005938 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1138383005939 putative metal binding site [ion binding]; other site 1138383005940 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138383005941 substrate binding site [chemical binding]; other site 1138383005942 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1138383005943 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1138383005944 quinone interaction residues [chemical binding]; other site 1138383005945 active site 1138383005946 catalytic residues [active] 1138383005947 FMN binding site [chemical binding]; other site 1138383005948 substrate binding site [chemical binding]; other site 1138383005949 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383005950 catalytic core [active] 1138383005951 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1138383005952 conserved hypothetical protein; Region: TIGR03843 1138383005953 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138383005954 active site 1138383005955 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1138383005956 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383005957 active site 1138383005958 HIGH motif; other site 1138383005959 nucleotide binding site [chemical binding]; other site 1138383005960 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383005961 active site 1138383005962 KMSKS motif; other site 1138383005963 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1138383005964 putative tRNA binding surface [nucleotide binding]; other site 1138383005965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383005966 Walker A/P-loop; other site 1138383005967 ATP binding site [chemical binding]; other site 1138383005968 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383005969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383005970 DNA binding residues [nucleotide binding] 1138383005971 dimerization interface [polypeptide binding]; other site 1138383005972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383005973 Walker A/P-loop; other site 1138383005974 ATP binding site [chemical binding]; other site 1138383005975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383005976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383005977 DNA binding residues [nucleotide binding] 1138383005978 dimerization interface [polypeptide binding]; other site 1138383005979 MbtH-like protein; Region: MbtH; pfam03621 1138383005980 Condensation domain; Region: Condensation; pfam00668 1138383005981 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383005982 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383005983 acyl-activating enzyme (AAE) consensus motif; other site 1138383005984 AMP binding site [chemical binding]; other site 1138383005985 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383005986 Condensation domain; Region: Condensation; pfam00668 1138383005987 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383005988 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383005989 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383005990 acyl-activating enzyme (AAE) consensus motif; other site 1138383005991 AMP binding site [chemical binding]; other site 1138383005992 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383005993 Condensation domain; Region: Condensation; pfam00668 1138383005994 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383005995 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383005996 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383005997 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383005998 acyl-activating enzyme (AAE) consensus motif; other site 1138383005999 AMP binding site [chemical binding]; other site 1138383006000 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383006001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383006002 S-adenosylmethionine binding site [chemical binding]; other site 1138383006003 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383006004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383006005 Condensation domain; Region: Condensation; pfam00668 1138383006006 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383006007 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383006008 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383006009 acyl-activating enzyme (AAE) consensus motif; other site 1138383006010 AMP binding site [chemical binding]; other site 1138383006011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383006012 Condensation domain; Region: Condensation; pfam00668 1138383006013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383006014 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383006015 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383006016 acyl-activating enzyme (AAE) consensus motif; other site 1138383006017 AMP binding site [chemical binding]; other site 1138383006018 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383006019 Thioesterase domain; Region: Thioesterase; pfam00975 1138383006020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383006021 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138383006022 putative substrate translocation pore; other site 1138383006023 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383006024 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383006025 active site 1138383006026 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1138383006027 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138383006028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006029 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138383006030 Enoylreductase; Region: PKS_ER; smart00829 1138383006031 NAD(P) binding site [chemical binding]; other site 1138383006032 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138383006033 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383006034 putative NADP binding site [chemical binding]; other site 1138383006035 active site 1138383006036 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383006037 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383006038 Cytochrome P450; Region: p450; cl12078 1138383006039 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138383006040 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138383006041 FAD binding pocket [chemical binding]; other site 1138383006042 FAD binding motif [chemical binding]; other site 1138383006043 phosphate binding motif [ion binding]; other site 1138383006044 NAD binding pocket [chemical binding]; other site 1138383006045 acyl-CoA synthetase; Validated; Region: PRK05850 1138383006046 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138383006047 acyl-activating enzyme (AAE) consensus motif; other site 1138383006048 active site 1138383006049 short chain dehydrogenase; Provisional; Region: PRK05872 1138383006050 classical (c) SDRs; Region: SDR_c; cd05233 1138383006051 NAD(P) binding site [chemical binding]; other site 1138383006052 active site 1138383006053 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138383006054 PAC2 family; Region: PAC2; pfam09754 1138383006055 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1138383006056 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1138383006057 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1138383006058 substrate binding pocket [chemical binding]; other site 1138383006059 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1138383006060 B12 binding site [chemical binding]; other site 1138383006061 cobalt ligand [ion binding]; other site 1138383006062 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1138383006063 Mannan-binding protein; Region: MVL; pfam12151 1138383006064 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138383006065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1138383006066 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383006067 mce related protein; Region: MCE; pfam02470 1138383006068 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383006069 mce related protein; Region: MCE; pfam02470 1138383006070 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383006071 mce related protein; Region: MCE; pfam02470 1138383006072 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383006073 mce related protein; Region: MCE; pfam02470 1138383006074 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383006075 mce related protein; Region: MCE; pfam02470 1138383006076 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383006077 mce related protein; Region: MCE; pfam02470 1138383006078 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383006079 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383006080 Permease; Region: Permease; pfam02405 1138383006081 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383006082 Permease; Region: Permease; pfam02405 1138383006083 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383006084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006085 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1138383006086 homodimer interface [polypeptide binding]; other site 1138383006087 putative metal binding site [ion binding]; other site 1138383006088 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1138383006089 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1138383006090 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1138383006091 Predicted membrane protein [Function unknown]; Region: COG3918 1138383006092 mercuric reductase; Validated; Region: PRK06370 1138383006093 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383006094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383006095 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383006096 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1138383006097 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1138383006098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383006099 S-adenosylmethionine binding site [chemical binding]; other site 1138383006100 Protein of unknown function (DUF503); Region: DUF503; cl00669 1138383006101 proteasome ATPase; Region: pup_AAA; TIGR03689 1138383006102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383006103 Walker A motif; other site 1138383006104 ATP binding site [chemical binding]; other site 1138383006105 Walker B motif; other site 1138383006106 arginine finger; other site 1138383006107 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1138383006108 Pup-like protein; Region: Pup; cl05289 1138383006109 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1138383006110 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138383006111 active site 1138383006112 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1138383006113 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138383006114 active site 1138383006115 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1138383006116 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138383006117 WYL domain; Region: WYL; pfam13280 1138383006118 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138383006119 WYL domain; Region: WYL; pfam13280 1138383006120 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1138383006121 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1138383006122 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1138383006123 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1138383006124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383006125 ATP binding site [chemical binding]; other site 1138383006126 putative Mg++ binding site [ion binding]; other site 1138383006127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383006128 nucleotide binding region [chemical binding]; other site 1138383006129 ATP-binding site [chemical binding]; other site 1138383006130 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1138383006131 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138383006132 5'-3' exonuclease; Region: 53EXOc; smart00475 1138383006133 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138383006134 active site 1138383006135 metal binding site 1 [ion binding]; metal-binding site 1138383006136 putative 5' ssDNA interaction site; other site 1138383006137 metal binding site 3; metal-binding site 1138383006138 metal binding site 2 [ion binding]; metal-binding site 1138383006139 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138383006140 putative DNA binding site [nucleotide binding]; other site 1138383006141 putative metal binding site [ion binding]; other site 1138383006142 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138383006143 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138383006144 active site 1138383006145 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1138383006146 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1138383006147 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138383006148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006149 NAD(P) binding site [chemical binding]; other site 1138383006150 active site 1138383006151 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1138383006152 active site 1138383006153 putative homodimer interface [polypeptide binding]; other site 1138383006154 SAM binding site [chemical binding]; other site 1138383006155 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1138383006156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383006157 S-adenosylmethionine binding site [chemical binding]; other site 1138383006158 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1138383006159 active site 1138383006160 SAM binding site [chemical binding]; other site 1138383006161 homodimer interface [polypeptide binding]; other site 1138383006162 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1138383006163 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1138383006164 Putative zinc-finger; Region: zf-HC2; pfam13490 1138383006165 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 1138383006166 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1138383006167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383006168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383006169 DNA binding residues [nucleotide binding] 1138383006170 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006171 PPE family; Region: PPE; pfam00823 1138383006172 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1138383006173 active site 1138383006174 SAM binding site [chemical binding]; other site 1138383006175 homodimer interface [polypeptide binding]; other site 1138383006176 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1138383006177 active site 1138383006178 SAM binding site [chemical binding]; other site 1138383006179 homodimer interface [polypeptide binding]; other site 1138383006180 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1138383006181 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1138383006182 precorrin-3B synthase; Region: CobG; TIGR02435 1138383006183 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138383006184 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138383006185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383006186 dimer interface [polypeptide binding]; other site 1138383006187 conserved gate region; other site 1138383006188 putative PBP binding loops; other site 1138383006189 ABC-ATPase subunit interface; other site 1138383006190 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138383006191 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138383006192 Walker A/P-loop; other site 1138383006193 ATP binding site [chemical binding]; other site 1138383006194 Q-loop/lid; other site 1138383006195 ABC transporter signature motif; other site 1138383006196 Walker B; other site 1138383006197 D-loop; other site 1138383006198 H-loop/switch region; other site 1138383006199 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138383006200 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383006201 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138383006202 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138383006203 Moco binding site; other site 1138383006204 metal coordination site [ion binding]; other site 1138383006205 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1138383006206 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138383006207 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138383006208 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138383006209 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1138383006210 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1138383006211 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1138383006212 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138383006213 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138383006214 active site 1138383006215 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1138383006216 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1138383006217 putative active site [active] 1138383006218 catalytic triad [active] 1138383006219 putative dimer interface [polypeptide binding]; other site 1138383006220 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1138383006221 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1138383006222 Ligand binding site; other site 1138383006223 Putative Catalytic site; other site 1138383006224 DXD motif; other site 1138383006225 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1138383006226 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383006227 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383006228 active site 1138383006229 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383006230 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138383006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006232 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138383006233 Enoylreductase; Region: PKS_ER; smart00829 1138383006234 NAD(P) binding site [chemical binding]; other site 1138383006235 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138383006236 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383006237 putative NADP binding site [chemical binding]; other site 1138383006238 active site 1138383006239 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383006240 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383006241 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383006242 active site 1138383006243 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383006244 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138383006245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006246 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138383006247 Enoylreductase; Region: PKS_ER; smart00829 1138383006248 NAD(P) binding site [chemical binding]; other site 1138383006249 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138383006250 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383006251 putative NADP binding site [chemical binding]; other site 1138383006252 active site 1138383006253 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383006254 hypothetical protein; Provisional; Region: PRK05865 1138383006255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006256 NAD(P) binding site [chemical binding]; other site 1138383006257 active site 1138383006258 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138383006259 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383006260 Cytochrome P450; Region: p450; cl12078 1138383006261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006262 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1138383006263 NAD(P) binding site [chemical binding]; other site 1138383006264 active site 1138383006265 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383006266 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383006267 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138383006268 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1138383006269 Walker A motif; other site 1138383006270 ATP binding site [chemical binding]; other site 1138383006271 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138383006272 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138383006273 metal ion-dependent adhesion site (MIDAS); other site 1138383006274 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383006275 short chain dehydrogenase; Provisional; Region: PRK07814 1138383006276 classical (c) SDRs; Region: SDR_c; cd05233 1138383006277 NAD(P) binding site [chemical binding]; other site 1138383006278 active site 1138383006279 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383006280 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383006281 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383006282 classical (c) SDRs; Region: SDR_c; cd05233 1138383006283 NAD(P) binding site [chemical binding]; other site 1138383006284 active site 1138383006285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383006286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006287 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383006288 Cytochrome P450; Region: p450; cl12078 1138383006289 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138383006290 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383006291 substrate binding pocket [chemical binding]; other site 1138383006292 catalytic triad [active] 1138383006293 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383006294 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383006295 Shikimate kinase; Region: SKI; pfam01202 1138383006296 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1138383006297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006298 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383006299 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383006300 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1138383006301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1138383006302 AAA domain; Region: AAA_33; pfam13671 1138383006303 Predicted membrane protein [Function unknown]; Region: COG2259 1138383006304 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1138383006305 catalytic triad [active] 1138383006306 conserved cis-peptide bond; other site 1138383006307 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138383006308 DoxX-like family; Region: DoxX_2; pfam13564 1138383006309 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138383006310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383006311 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138383006312 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138383006313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138383006314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383006315 dimer interface [polypeptide binding]; other site 1138383006316 conserved gate region; other site 1138383006317 putative PBP binding loops; other site 1138383006318 ABC-ATPase subunit interface; other site 1138383006319 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138383006320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383006321 dimer interface [polypeptide binding]; other site 1138383006322 conserved gate region; other site 1138383006323 putative PBP binding loops; other site 1138383006324 ABC-ATPase subunit interface; other site 1138383006325 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138383006326 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138383006327 Walker A/P-loop; other site 1138383006328 ATP binding site [chemical binding]; other site 1138383006329 Q-loop/lid; other site 1138383006330 ABC transporter signature motif; other site 1138383006331 Walker B; other site 1138383006332 D-loop; other site 1138383006333 H-loop/switch region; other site 1138383006334 TOBE domain; Region: TOBE_2; pfam08402 1138383006335 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138383006336 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1138383006337 nucleophile elbow; other site 1138383006338 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138383006339 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1138383006340 Iron permease FTR1 family; Region: FTR1; cl00475 1138383006341 Imelysin; Region: Peptidase_M75; pfam09375 1138383006342 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1138383006343 OsmC-like protein; Region: OsmC; pfam02566 1138383006344 cyanate hydratase; Validated; Region: PRK02866 1138383006345 Helix-turn-helix domain; Region: HTH_19; pfam12844 1138383006346 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1138383006347 oligomer interface [polypeptide binding]; other site 1138383006348 active site 1138383006349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383006350 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383006351 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 1138383006352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383006353 DNA binding residues [nucleotide binding] 1138383006354 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1138383006355 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138383006356 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383006357 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383006358 active site 1138383006359 catalytic tetrad [active] 1138383006360 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138383006361 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1138383006362 putative NADP binding site [chemical binding]; other site 1138383006363 putative substrate binding site [chemical binding]; other site 1138383006364 active site 1138383006365 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138383006366 extended (e) SDRs; Region: SDR_e; cd08946 1138383006367 NAD(P) binding site [chemical binding]; other site 1138383006368 active site 1138383006369 substrate binding site [chemical binding]; other site 1138383006370 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383006371 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138383006372 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383006373 active site 2 [active] 1138383006374 active site 1 [active] 1138383006375 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1138383006376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383006377 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383006378 active site 1138383006379 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138383006380 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383006381 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1138383006382 homotetramer interface [polypeptide binding]; other site 1138383006383 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383006384 NAD binding site [chemical binding]; other site 1138383006385 homodimer interface [polypeptide binding]; other site 1138383006386 active site 1138383006387 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138383006388 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383006389 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383006390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006391 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383006392 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383006393 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383006394 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383006395 substrate binding site [chemical binding]; other site 1138383006396 oxyanion hole (OAH) forming residues; other site 1138383006397 trimer interface [polypeptide binding]; other site 1138383006398 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1138383006399 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1138383006400 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1138383006401 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1138383006402 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138383006403 active site 1138383006404 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138383006405 catalytic triad [active] 1138383006406 dimer interface [polypeptide binding]; other site 1138383006407 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138383006408 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1138383006409 active site 1138383006410 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383006411 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1138383006412 active site 1138383006413 substrate binding site [chemical binding]; other site 1138383006414 ATP binding site [chemical binding]; other site 1138383006415 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1138383006416 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138383006417 potential catalytic triad [active] 1138383006418 conserved cys residue [active] 1138383006419 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383006420 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383006421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006422 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138383006423 active site 1138383006424 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1138383006425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383006426 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138383006427 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1138383006428 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1138383006429 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383006430 hydrophobic ligand binding site; other site 1138383006431 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383006432 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383006433 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138383006434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006435 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138383006436 Cutinase; Region: Cutinase; pfam01083 1138383006437 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1138383006438 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383006439 potential frameshift: common BLAST hit: gi|118462899|ref|YP_883383.1| response regulator receiver modulated serine phosphatase 1138383006440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383006441 active site 1138383006442 phosphorylation site [posttranslational modification] 1138383006443 intermolecular recognition site; other site 1138383006444 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138383006445 Cutinase; Region: Cutinase; pfam01083 1138383006446 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006447 PPE family; Region: PPE; pfam00823 1138383006448 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006449 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138383006450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1138383006451 putative PBP binding loops; other site 1138383006452 ABC-ATPase subunit interface; other site 1138383006453 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138383006454 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138383006455 Walker A/P-loop; other site 1138383006456 ATP binding site [chemical binding]; other site 1138383006457 Q-loop/lid; other site 1138383006458 ABC transporter signature motif; other site 1138383006459 Walker B; other site 1138383006460 D-loop; other site 1138383006461 H-loop/switch region; other site 1138383006462 NMT1-like family; Region: NMT1_2; pfam13379 1138383006463 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1138383006464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383006465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383006466 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1138383006467 putative dimerization interface [polypeptide binding]; other site 1138383006468 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006469 PPE family; Region: PPE; pfam00823 1138383006470 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1138383006472 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1138383006473 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1138383006474 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383006475 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138383006476 short chain dehydrogenase; Provisional; Region: PRK06500 1138383006477 classical (c) SDRs; Region: SDR_c; cd05233 1138383006478 NAD(P) binding site [chemical binding]; other site 1138383006479 active site 1138383006480 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138383006481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383006482 S-adenosylmethionine binding site [chemical binding]; other site 1138383006483 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1138383006484 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1138383006485 putative oligomer interface [polypeptide binding]; other site 1138383006486 putative active site [active] 1138383006487 metal binding site [ion binding]; metal-binding site 1138383006488 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138383006489 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383006490 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383006491 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1138383006492 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138383006493 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138383006494 hypothetical protein; Provisional; Region: PRK06834 1138383006495 hypothetical protein; Provisional; Region: PRK07236 1138383006496 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383006497 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1138383006498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383006499 ATP binding site [chemical binding]; other site 1138383006500 putative Mg++ binding site [ion binding]; other site 1138383006501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383006502 nucleotide binding region [chemical binding]; other site 1138383006503 ATP-binding site [chemical binding]; other site 1138383006504 Helicase associated domain (HA2); Region: HA2; pfam04408 1138383006505 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1138383006506 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1138383006507 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1138383006508 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383006509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383006510 substrate binding site [chemical binding]; other site 1138383006511 oxyanion hole (OAH) forming residues; other site 1138383006512 trimer interface [polypeptide binding]; other site 1138383006513 Cutinase; Region: Cutinase; pfam01083 1138383006514 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1138383006515 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383006516 catalytic Zn binding site [ion binding]; other site 1138383006517 NAD(P) binding site [chemical binding]; other site 1138383006518 structural Zn binding site [ion binding]; other site 1138383006519 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383006520 hydrophobic ligand binding site; other site 1138383006521 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1138383006522 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383006523 NAD binding site [chemical binding]; other site 1138383006524 catalytic Zn binding site [ion binding]; other site 1138383006525 structural Zn binding site [ion binding]; other site 1138383006526 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1138383006527 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1138383006528 MOSC domain; Region: MOSC; pfam03473 1138383006529 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006530 PPE family; Region: PPE; pfam00823 1138383006531 Short C-terminal domain; Region: SHOCT; pfam09851 1138383006532 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138383006533 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138383006534 active site 1138383006535 TDP-binding site; other site 1138383006536 acceptor substrate-binding pocket; other site 1138383006537 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383006538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383006539 S-adenosylmethionine binding site [chemical binding]; other site 1138383006540 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138383006541 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1138383006542 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138383006543 iron-sulfur cluster [ion binding]; other site 1138383006544 [2Fe-2S] cluster binding site [ion binding]; other site 1138383006545 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1138383006546 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138383006547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138383006548 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138383006549 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138383006550 metal binding site 2 [ion binding]; metal-binding site 1138383006551 putative DNA binding helix; other site 1138383006552 metal binding site 1 [ion binding]; metal-binding site 1138383006553 dimer interface [polypeptide binding]; other site 1138383006554 structural Zn2+ binding site [ion binding]; other site 1138383006555 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1138383006556 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1138383006557 dimer interface [polypeptide binding]; other site 1138383006558 active site 1138383006559 heme binding site [chemical binding]; other site 1138383006560 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1138383006561 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1138383006562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383006563 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383006564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383006565 S-adenosylmethionine binding site [chemical binding]; other site 1138383006566 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1138383006567 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1138383006568 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138383006569 Cutinase; Region: Cutinase; pfam01083 1138383006570 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383006571 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383006572 putative transposase OrfB; Reviewed; Region: PHA02517 1138383006573 HTH-like domain; Region: HTH_21; pfam13276 1138383006574 Integrase core domain; Region: rve; pfam00665 1138383006575 Integrase core domain; Region: rve_3; pfam13683 1138383006576 Transposase; Region: HTH_Tnp_1; cl17663 1138383006577 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383006578 PE family; Region: PE; pfam00934 1138383006579 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1138383006580 active site 1138383006581 catalytic residues [active] 1138383006582 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383006583 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138383006584 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383006585 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383006586 NAD(P) binding site [chemical binding]; other site 1138383006587 catalytic residues [active] 1138383006588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1138383006589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383006590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383006591 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138383006592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383006593 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383006594 extended (e) SDRs; Region: SDR_e; cd08946 1138383006595 NAD(P) binding site [chemical binding]; other site 1138383006596 active site 1138383006597 substrate binding site [chemical binding]; other site 1138383006598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383006599 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383006600 active site 1138383006601 YacP-like NYN domain; Region: NYN_YacP; cl01491 1138383006602 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1138383006603 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383006604 FMN binding site [chemical binding]; other site 1138383006605 substrate binding site [chemical binding]; other site 1138383006606 putative catalytic residue [active] 1138383006607 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1138383006608 dimer interface [polypeptide binding]; other site 1138383006609 catalytic triad [active] 1138383006610 peroxidatic and resolving cysteines [active] 1138383006611 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138383006612 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138383006613 conserved cys residue [active] 1138383006614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383006615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383006616 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138383006617 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138383006618 conserved cys residue [active] 1138383006619 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138383006620 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138383006621 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1138383006622 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383006623 short chain dehydrogenase; Provisional; Region: PRK05867 1138383006624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006625 NAD(P) binding site [chemical binding]; other site 1138383006626 active site 1138383006627 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383006628 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383006629 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1138383006630 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138383006631 acyl-activating enzyme (AAE) consensus motif; other site 1138383006632 active site 1138383006633 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138383006634 putative hydrophobic ligand binding site [chemical binding]; other site 1138383006635 protein interface [polypeptide binding]; other site 1138383006636 gate; other site 1138383006637 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138383006638 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138383006639 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138383006640 tetramer interface [polypeptide binding]; other site 1138383006641 active site 1138383006642 Mg2+/Mn2+ binding site [ion binding]; other site 1138383006643 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1138383006644 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383006645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383006646 dimerization interface [polypeptide binding]; other site 1138383006647 putative DNA binding site [nucleotide binding]; other site 1138383006648 putative Zn2+ binding site [ion binding]; other site 1138383006649 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1138383006650 putative hydrophobic ligand binding site [chemical binding]; other site 1138383006651 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138383006652 putative hydrophobic ligand binding site [chemical binding]; other site 1138383006653 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138383006654 substrate binding site [chemical binding]; other site 1138383006655 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138383006656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383006657 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383006658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006659 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1138383006660 Nitronate monooxygenase; Region: NMO; pfam03060 1138383006661 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383006662 FMN binding site [chemical binding]; other site 1138383006663 substrate binding site [chemical binding]; other site 1138383006664 putative catalytic residue [active] 1138383006665 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138383006666 FMN binding site [chemical binding]; other site 1138383006667 dimer interface [polypeptide binding]; other site 1138383006668 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383006669 hydrophobic ligand binding site; other site 1138383006670 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138383006671 Predicted membrane protein [Function unknown]; Region: COG1950 1138383006672 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383006673 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383006674 active site 1138383006675 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383006676 putative sialic acid transporter; Region: 2A0112; TIGR00891 1138383006677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383006678 putative substrate translocation pore; other site 1138383006679 competence damage-inducible protein A; Provisional; Region: PRK00549 1138383006680 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1138383006681 putative MPT binding site; other site 1138383006682 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1138383006683 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1138383006684 putative ADP-ribose binding site [chemical binding]; other site 1138383006685 Domain of unknown function DUF77; Region: DUF77; pfam01910 1138383006686 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1138383006687 putative active site [active] 1138383006688 dimerization interface [polypeptide binding]; other site 1138383006689 putative tRNAtyr binding site [nucleotide binding]; other site 1138383006690 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383006691 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383006692 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138383006693 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383006694 NAD(P) binding site [chemical binding]; other site 1138383006695 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383006696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383006697 Nitronate monooxygenase; Region: NMO; pfam03060 1138383006698 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383006699 FMN binding site [chemical binding]; other site 1138383006700 substrate binding site [chemical binding]; other site 1138383006701 putative catalytic residue [active] 1138383006702 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383006703 Cytochrome P450; Region: p450; cl12078 1138383006704 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1138383006705 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1138383006706 putative NAD(P) binding site [chemical binding]; other site 1138383006707 putative substrate binding site [chemical binding]; other site 1138383006708 catalytic Zn binding site [ion binding]; other site 1138383006709 structural Zn binding site [ion binding]; other site 1138383006710 YceI-like domain; Region: YceI; smart00867 1138383006711 Putative esterase; Region: Esterase; pfam00756 1138383006712 chorismate mutase; Provisional; Region: PRK09269 1138383006713 Chorismate mutase type II; Region: CM_2; cl00693 1138383006714 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138383006715 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383006716 hydrophobic ligand binding site; other site 1138383006717 short chain dehydrogenase; Provisional; Region: PRK08267 1138383006718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006719 NAD(P) binding site [chemical binding]; other site 1138383006720 active site 1138383006721 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138383006722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383006723 Cytochrome P450; Region: p450; cl12078 1138383006724 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383006725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383006726 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138383006727 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138383006728 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1138383006729 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138383006730 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383006731 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383006732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383006733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138383006734 putative substrate translocation pore; other site 1138383006735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383006736 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1138383006737 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1138383006738 heme binding site [chemical binding]; other site 1138383006739 ferroxidase pore; other site 1138383006740 ferroxidase diiron center [ion binding]; other site 1138383006741 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1138383006742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383006743 substrate binding site [chemical binding]; other site 1138383006744 oxyanion hole (OAH) forming residues; other site 1138383006745 trimer interface [polypeptide binding]; other site 1138383006746 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138383006747 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1138383006748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383006749 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1138383006750 dimerization interface [polypeptide binding]; other site 1138383006751 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138383006752 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1138383006753 dimer interface [polypeptide binding]; other site 1138383006754 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1138383006755 catalytic triad [active] 1138383006756 peroxidatic and resolving cysteines [active] 1138383006757 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1138383006758 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383006759 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1138383006760 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138383006761 active site 1138383006762 catalytic site [active] 1138383006763 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1138383006764 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1138383006765 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1138383006766 active site 1138383006767 substrate binding site [chemical binding]; other site 1138383006768 FMN binding site [chemical binding]; other site 1138383006769 putative catalytic residues [active] 1138383006770 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1138383006771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383006772 Walker A motif; other site 1138383006773 ATP binding site [chemical binding]; other site 1138383006774 Walker B motif; other site 1138383006775 arginine finger; other site 1138383006776 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1138383006777 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383006778 TfoX N-terminal domain; Region: TfoX_N; cl17592 1138383006779 Protein of unknown function DUF72; Region: DUF72; pfam01904 1138383006780 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138383006781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383006782 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383006783 hypothetical protein; Provisional; Region: PRK12320 1138383006784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383006785 NAD(P) binding site [chemical binding]; other site 1138383006786 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138383006787 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383006788 active site 1138383006789 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383006790 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383006791 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383006792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383006793 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1138383006794 short chain dehydrogenase; Provisional; Region: PRK07825 1138383006795 classical (c) SDRs; Region: SDR_c; cd05233 1138383006796 NAD(P) binding site [chemical binding]; other site 1138383006797 active site 1138383006798 putative phosphoketolase; Provisional; Region: PRK05261 1138383006799 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1138383006800 TPP-binding site; other site 1138383006801 XFP C-terminal domain; Region: XFP_C; pfam09363 1138383006802 CAAX protease self-immunity; Region: Abi; pfam02517 1138383006803 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138383006804 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1138383006805 NAD(P) binding site [chemical binding]; other site 1138383006806 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1138383006807 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1138383006808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383006809 Walker A/P-loop; other site 1138383006810 ATP binding site [chemical binding]; other site 1138383006811 Q-loop/lid; other site 1138383006812 ABC transporter signature motif; other site 1138383006813 Walker B; other site 1138383006814 D-loop; other site 1138383006815 H-loop/switch region; other site 1138383006816 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138383006817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383006818 putative PBP binding loops; other site 1138383006819 ABC-ATPase subunit interface; other site 1138383006820 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1138383006821 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1138383006822 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138383006823 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1138383006824 classical (c) SDRs; Region: SDR_c; cd05233 1138383006825 NAD(P) binding site [chemical binding]; other site 1138383006826 active site 1138383006827 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1138383006828 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138383006829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383006830 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383006831 CoenzymeA binding site [chemical binding]; other site 1138383006832 subunit interaction site [polypeptide binding]; other site 1138383006833 PHB binding site; other site 1138383006834 Predicted transcriptional regulator [Transcription]; Region: COG3682 1138383006835 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1138383006836 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383006837 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1138383006838 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1138383006839 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1138383006840 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138383006841 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138383006842 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138383006843 active site 1138383006844 acyl carrier protein; Validated; Region: PRK05883 1138383006845 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1138383006846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383006847 acyl-activating enzyme (AAE) consensus motif; other site 1138383006848 AMP binding site [chemical binding]; other site 1138383006849 active site 1138383006850 CoA binding site [chemical binding]; other site 1138383006851 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1138383006852 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383006853 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383006854 active site 1138383006855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138383006856 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138383006857 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138383006858 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138383006859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138383006860 Transporter associated domain; Region: CorC_HlyC; smart01091 1138383006861 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138383006862 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138383006863 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138383006864 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1138383006865 active site 1138383006866 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1138383006867 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138383006868 metal ion-dependent adhesion site (MIDAS); other site 1138383006869 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138383006870 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138383006871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383006872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006873 glycine dehydrogenase; Provisional; Region: PRK05367 1138383006874 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138383006875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383006876 tetramer interface [polypeptide binding]; other site 1138383006877 catalytic residue [active] 1138383006878 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138383006879 tetramer interface [polypeptide binding]; other site 1138383006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383006881 catalytic residue [active] 1138383006882 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1138383006883 DNA binding residues [nucleotide binding] 1138383006884 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383006885 putative dimer interface [polypeptide binding]; other site 1138383006886 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1138383006887 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1138383006888 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383006889 DNA binding residues [nucleotide binding] 1138383006890 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383006891 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383006892 phosphopeptide binding site; other site 1138383006893 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1138383006894 lipoyl attachment site [posttranslational modification]; other site 1138383006895 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138383006896 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1138383006897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138383006898 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138383006899 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138383006900 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1138383006901 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1138383006902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1138383006903 nucleotide binding region [chemical binding]; other site 1138383006904 ATP-binding site [chemical binding]; other site 1138383006905 hypothetical protein; Provisional; Region: PRK05858 1138383006906 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138383006907 PYR/PP interface [polypeptide binding]; other site 1138383006908 dimer interface [polypeptide binding]; other site 1138383006909 TPP binding site [chemical binding]; other site 1138383006910 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383006911 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138383006912 TPP-binding site; other site 1138383006913 dimer interface [polypeptide binding]; other site 1138383006914 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1138383006915 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1138383006916 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1138383006917 hypothetical protein; Validated; Region: PRK07121 1138383006918 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138383006919 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138383006920 active site 1138383006921 metal binding site [ion binding]; metal-binding site 1138383006922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383006923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383006924 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1138383006925 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1138383006926 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1138383006927 MgtC family; Region: MgtC; pfam02308 1138383006928 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383006929 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006930 PPE family; Region: PPE; pfam00823 1138383006931 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006932 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006933 PPE family; Region: PPE; pfam00823 1138383006934 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006935 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383006936 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383006937 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006938 PPE family; Region: PPE; pfam00823 1138383006939 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006940 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006941 PPE family; Region: PPE; pfam00823 1138383006942 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006943 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006944 PPE family; Region: PPE; pfam00823 1138383006945 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138383006946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383006947 Walker A motif; other site 1138383006948 ATP binding site [chemical binding]; other site 1138383006949 Walker B motif; other site 1138383006950 arginine finger; other site 1138383006951 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138383006952 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138383006953 catalytic residues [active] 1138383006954 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138383006955 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1138383006956 active site 1138383006957 catalytic residues [active] 1138383006958 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138383006959 EspG family; Region: ESX-1_EspG; pfam14011 1138383006960 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138383006961 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138383006962 PE family; Region: PE; pfam00934 1138383006963 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006964 PPE family; Region: PPE; pfam00823 1138383006965 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006966 PPE family; Region: PPE; pfam00823 1138383006967 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006968 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006969 PPE family; Region: PPE; pfam00823 1138383006970 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383006971 PPE family; Region: PPE; pfam00823 1138383006972 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383006973 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138383006974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383006975 Cytochrome P450; Region: p450; cl12078 1138383006976 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138383006977 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383006978 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138383006979 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383006980 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138383006981 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1138383006982 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1138383006983 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383006984 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383006985 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383006986 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1138383006987 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1138383006988 Moco binding site; other site 1138383006989 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138383006990 metal coordination site [ion binding]; other site 1138383006991 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138383006992 hydrophobic ligand binding site; other site 1138383006993 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383006994 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383006995 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138383006996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383006997 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383006998 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383006999 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007000 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007001 classical (c) SDRs; Region: SDR_c; cd05233 1138383007002 NAD(P) binding site [chemical binding]; other site 1138383007003 active site 1138383007004 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1138383007005 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138383007006 tetramer interface [polypeptide binding]; other site 1138383007007 TPP-binding site [chemical binding]; other site 1138383007008 heterodimer interface [polypeptide binding]; other site 1138383007009 phosphorylation loop region [posttranslational modification] 1138383007010 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1138383007011 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1138383007012 alpha subunit interface [polypeptide binding]; other site 1138383007013 TPP binding site [chemical binding]; other site 1138383007014 heterodimer interface [polypeptide binding]; other site 1138383007015 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138383007016 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138383007017 E3 interaction surface; other site 1138383007018 lipoyl attachment site [posttranslational modification]; other site 1138383007019 enoyl-CoA hydratase; Provisional; Region: PRK06144 1138383007020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007021 substrate binding site [chemical binding]; other site 1138383007022 oxyanion hole (OAH) forming residues; other site 1138383007023 trimer interface [polypeptide binding]; other site 1138383007024 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138383007025 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007026 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383007027 acyl-activating enzyme (AAE) consensus motif; other site 1138383007028 putative AMP binding site [chemical binding]; other site 1138383007029 putative active site [active] 1138383007030 acyl-activating enzyme (AAE) consensus motif; other site 1138383007031 putative CoA binding site [chemical binding]; other site 1138383007032 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383007033 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383007034 [2Fe-2S] cluster binding site [ion binding]; other site 1138383007035 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383007036 hydrophobic ligand binding site; other site 1138383007037 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1138383007038 enoyl-CoA hydratase; Provisional; Region: PRK06190 1138383007039 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007040 substrate binding site [chemical binding]; other site 1138383007041 oxyanion hole (OAH) forming residues; other site 1138383007042 trimer interface [polypeptide binding]; other site 1138383007043 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1138383007044 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1138383007045 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 1138383007046 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1138383007047 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138383007048 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1138383007049 ATP binding site [chemical binding]; other site 1138383007050 Mg++ binding site [ion binding]; other site 1138383007051 motif III; other site 1138383007052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383007053 nucleotide binding region [chemical binding]; other site 1138383007054 ATP-binding site [chemical binding]; other site 1138383007055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383007056 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383007057 S-adenosylmethionine binding site [chemical binding]; other site 1138383007058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007060 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138383007061 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383007062 active site 1138383007063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383007064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007066 classical (c) SDRs; Region: SDR_c; cd05233 1138383007067 NAD(P) binding site [chemical binding]; other site 1138383007068 active site 1138383007069 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1138383007070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383007071 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138383007072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383007073 DNA binding residues [nucleotide binding] 1138383007074 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138383007075 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1138383007076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007077 Cytochrome P450; Region: p450; cl12078 1138383007078 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007079 potential frameshift: common BLAST hit: gi|41407566|ref|NP_960402.1| short chain dehydrogenase 1138383007080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007081 NAD(P) binding site [chemical binding]; other site 1138383007082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007083 active site 1138383007084 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383007085 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138383007086 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138383007087 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138383007088 active site 1138383007089 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138383007090 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138383007091 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138383007092 active site 1138383007093 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383007094 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383007095 active site 1138383007096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007097 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138383007098 NAD(P) binding site [chemical binding]; other site 1138383007099 active site 1138383007100 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007101 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007102 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007103 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007104 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007105 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138383007106 substrate binding site [chemical binding]; other site 1138383007107 oxyanion hole (OAH) forming residues; other site 1138383007108 trimer interface [polypeptide binding]; other site 1138383007109 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007110 classical (c) SDRs; Region: SDR_c; cd05233 1138383007111 NAD(P) binding site [chemical binding]; other site 1138383007112 active site 1138383007113 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007114 Cytochrome P450; Region: p450; cl12078 1138383007115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007117 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1138383007118 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138383007119 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1138383007120 hypothetical protein; Provisional; Region: PRK06185 1138383007121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383007122 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383007123 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138383007124 Sulfatase; Region: Sulfatase; pfam00884 1138383007125 Nitronate monooxygenase; Region: NMO; pfam03060 1138383007126 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383007127 FMN binding site [chemical binding]; other site 1138383007128 substrate binding site [chemical binding]; other site 1138383007129 putative catalytic residue [active] 1138383007130 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383007131 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138383007132 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383007133 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1138383007134 intersubunit interface [polypeptide binding]; other site 1138383007135 active site 1138383007136 Zn2+ binding site [ion binding]; other site 1138383007137 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383007138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007139 acyl-activating enzyme (AAE) consensus motif; other site 1138383007140 AMP binding site [chemical binding]; other site 1138383007141 active site 1138383007142 CoA binding site [chemical binding]; other site 1138383007143 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138383007144 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1138383007145 Moco binding site; other site 1138383007146 metal coordination site [ion binding]; other site 1138383007147 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138383007148 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1138383007149 putative di-iron ligands [ion binding]; other site 1138383007150 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138383007151 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138383007152 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138383007153 FAD binding pocket [chemical binding]; other site 1138383007154 FAD binding motif [chemical binding]; other site 1138383007155 phosphate binding motif [ion binding]; other site 1138383007156 beta-alpha-beta structure motif; other site 1138383007157 NAD binding pocket [chemical binding]; other site 1138383007158 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383007159 catalytic loop [active] 1138383007160 iron binding site [ion binding]; other site 1138383007161 acyl-CoA synthetase; Provisional; Region: PRK13388 1138383007162 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007163 acyl-activating enzyme (AAE) consensus motif; other site 1138383007164 AMP binding site [chemical binding]; other site 1138383007165 active site 1138383007166 CoA binding site [chemical binding]; other site 1138383007167 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383007168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383007169 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383007170 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383007171 thiolase; Provisional; Region: PRK06158 1138383007172 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007173 active site 1138383007174 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138383007175 putative active site [active] 1138383007176 putative catalytic site [active] 1138383007177 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138383007178 active site 1138383007179 catalytic site [active] 1138383007180 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007181 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007182 active site 1138383007183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007185 active site 1138383007186 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383007187 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383007188 phosphopeptide binding site; other site 1138383007189 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383007190 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383007191 phosphopeptide binding site; other site 1138383007192 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138383007193 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138383007194 Walker A/P-loop; other site 1138383007195 ATP binding site [chemical binding]; other site 1138383007196 Q-loop/lid; other site 1138383007197 ABC transporter signature motif; other site 1138383007198 Walker B; other site 1138383007199 D-loop; other site 1138383007200 H-loop/switch region; other site 1138383007201 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138383007202 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138383007203 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383007204 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383007205 short chain dehydrogenase; Provisional; Region: PRK06057 1138383007206 classical (c) SDRs; Region: SDR_c; cd05233 1138383007207 NAD(P) binding site [chemical binding]; other site 1138383007208 active site 1138383007209 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383007210 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138383007211 molybdopterin cofactor binding site; other site 1138383007212 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138383007213 putative molybdopterin cofactor binding site; other site 1138383007214 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383007215 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383007216 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383007217 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1138383007218 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138383007219 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383007220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007221 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138383007222 NAD(P) binding site [chemical binding]; other site 1138383007223 active site 1138383007224 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007225 classical (c) SDRs; Region: SDR_c; cd05233 1138383007226 NAD(P) binding site [chemical binding]; other site 1138383007227 active site 1138383007228 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007229 classical (c) SDRs; Region: SDR_c; cd05233 1138383007230 NAD(P) binding site [chemical binding]; other site 1138383007231 active site 1138383007232 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383007233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383007234 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138383007235 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383007236 catalytic loop [active] 1138383007237 iron binding site [ion binding]; other site 1138383007238 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007239 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007240 active site 1138383007241 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138383007242 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1138383007243 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1138383007244 active site 1138383007245 Fe binding site [ion binding]; other site 1138383007246 hypothetical protein; Validated; Region: PRK07121 1138383007247 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138383007248 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383007249 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138383007250 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138383007251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383007252 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383007253 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138383007254 active site 1138383007255 FMN binding site [chemical binding]; other site 1138383007256 substrate binding site [chemical binding]; other site 1138383007257 putative catalytic residue [active] 1138383007258 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1138383007259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007260 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138383007261 NAD(P) binding site [chemical binding]; other site 1138383007262 active site 1138383007263 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383007264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383007265 acyl-CoA synthetase; Validated; Region: PRK08316 1138383007266 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383007267 acyl-activating enzyme (AAE) consensus motif; other site 1138383007268 putative AMP binding site [chemical binding]; other site 1138383007269 putative active site [active] 1138383007270 putative CoA binding site [chemical binding]; other site 1138383007271 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007272 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007273 active site 1138383007274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007275 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383007276 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007278 SnoaL-like domain; Region: SnoaL_4; cl17707 1138383007279 hypothetical protein; Provisional; Region: PRK06194 1138383007280 classical (c) SDRs; Region: SDR_c; cd05233 1138383007281 NAD(P) binding site [chemical binding]; other site 1138383007282 active site 1138383007283 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383007284 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383007285 classical (c) SDRs; Region: SDR_c; cd05233 1138383007286 NAD(P) binding site [chemical binding]; other site 1138383007287 active site 1138383007288 short chain dehydrogenase; Provisional; Region: PRK08303 1138383007289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007290 NAD(P) binding site [chemical binding]; other site 1138383007291 active site 1138383007292 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383007293 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1138383007294 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1138383007295 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138383007296 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383007297 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383007298 active site 1138383007299 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383007300 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138383007301 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138383007302 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383007303 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383007304 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138383007305 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138383007306 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1138383007307 hypothetical protein; Provisional; Region: PRK14059 1138383007308 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1138383007309 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383007310 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383007311 active site 1138383007312 ATP binding site [chemical binding]; other site 1138383007313 substrate binding site [chemical binding]; other site 1138383007314 activation loop (A-loop); other site 1138383007315 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1138383007316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383007317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383007318 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1138383007319 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138383007320 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383007321 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383007322 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1138383007323 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1138383007324 dimer interface [polypeptide binding]; other site 1138383007325 active site 1138383007326 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1138383007327 Ligand Binding Site [chemical binding]; other site 1138383007328 Molecular Tunnel; other site 1138383007329 Condensation domain; Region: Condensation; pfam00668 1138383007330 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007331 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383007332 acyl-activating enzyme (AAE) consensus motif; other site 1138383007333 AMP binding site [chemical binding]; other site 1138383007334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007335 Condensation domain; Region: Condensation; pfam00668 1138383007336 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383007337 Condensation domain; Region: Condensation; pfam00668 1138383007338 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383007339 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007340 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383007341 acyl-activating enzyme (AAE) consensus motif; other site 1138383007342 AMP binding site [chemical binding]; other site 1138383007343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383007344 S-adenosylmethionine binding site [chemical binding]; other site 1138383007345 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007346 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007347 Condensation domain; Region: Condensation; pfam00668 1138383007348 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383007349 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383007350 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007351 acyl-activating enzyme (AAE) consensus motif; other site 1138383007352 AMP binding site [chemical binding]; other site 1138383007353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007354 Condensation domain; Region: Condensation; pfam00668 1138383007355 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383007356 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383007357 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007358 acyl-activating enzyme (AAE) consensus motif; other site 1138383007359 AMP binding site [chemical binding]; other site 1138383007360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007361 peptide synthase; Provisional; Region: PRK12316 1138383007362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383007363 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007364 acyl-activating enzyme (AAE) consensus motif; other site 1138383007365 AMP binding site [chemical binding]; other site 1138383007366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007367 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383007368 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383007369 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007370 acyl-activating enzyme (AAE) consensus motif; other site 1138383007371 AMP binding site [chemical binding]; other site 1138383007372 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007373 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383007374 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007375 acyl-activating enzyme (AAE) consensus motif; other site 1138383007376 AMP binding site [chemical binding]; other site 1138383007377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007378 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383007379 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383007380 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383007381 acyl-activating enzyme (AAE) consensus motif; other site 1138383007382 AMP binding site [chemical binding]; other site 1138383007383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383007384 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1138383007385 MbtH-like protein; Region: MbtH; pfam03621 1138383007386 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138383007387 PAS fold; Region: PAS_4; pfam08448 1138383007388 ANTAR domain; Region: ANTAR; pfam03861 1138383007389 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138383007390 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138383007391 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138383007392 DNA-binding site [nucleotide binding]; DNA binding site 1138383007393 RNA-binding motif; other site 1138383007394 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138383007395 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138383007396 putative di-iron ligands [ion binding]; other site 1138383007397 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1138383007398 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1138383007399 NAD(P) binding site [chemical binding]; other site 1138383007400 catalytic residues [active] 1138383007401 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1138383007402 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1138383007403 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138383007404 active site 1138383007405 catalytic residues [active] 1138383007406 DNA binding site [nucleotide binding] 1138383007407 Int/Topo IB signature motif; other site 1138383007408 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138383007409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138383007410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138383007411 catalytic residue [active] 1138383007412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007414 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383007415 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007416 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383007417 active site 1138383007418 CoA binding site [chemical binding]; other site 1138383007419 AMP binding site [chemical binding]; other site 1138383007420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007421 short chain dehydrogenase; Provisional; Region: PRK06197 1138383007422 NAD(P) binding site [chemical binding]; other site 1138383007423 active site 1138383007424 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007425 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007426 active site 1138383007427 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138383007428 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383007429 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383007430 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1138383007431 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383007432 lipid-transfer protein; Provisional; Region: PRK07855 1138383007433 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007434 active site 1138383007435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007436 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383007437 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007438 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007439 active site 1138383007440 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007441 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007442 active site 1138383007443 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1138383007444 putative FMN binding site [chemical binding]; other site 1138383007445 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138383007446 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383007447 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383007448 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007449 Cytochrome P450; Region: p450; cl12078 1138383007450 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383007451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007452 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383007453 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007454 classical (c) SDRs; Region: SDR_c; cd05233 1138383007455 NAD(P) binding site [chemical binding]; other site 1138383007456 active site 1138383007457 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138383007458 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383007459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007461 active site 1138383007462 Cytochrome P450; Region: p450; cl12078 1138383007463 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007464 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138383007465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383007466 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138383007467 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 1138383007468 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1138383007469 active site 1138383007470 metal binding site [ion binding]; metal-binding site 1138383007471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007475 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383007476 active site 2 [active] 1138383007477 active site 1 [active] 1138383007478 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1138383007479 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383007480 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383007481 NAD(P) binding site [chemical binding]; other site 1138383007482 catalytic residues [active] 1138383007483 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138383007484 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138383007485 NAD binding site [chemical binding]; other site 1138383007486 catalytic Zn binding site [ion binding]; other site 1138383007487 substrate binding site [chemical binding]; other site 1138383007488 structural Zn binding site [ion binding]; other site 1138383007489 Isochorismatase family; Region: Isochorismatase; pfam00857 1138383007490 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138383007491 catalytic triad [active] 1138383007492 conserved cis-peptide bond; other site 1138383007493 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138383007494 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1138383007495 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007496 Cytochrome P450; Region: p450; cl12078 1138383007497 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383007498 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007499 substrate binding site [chemical binding]; other site 1138383007500 oxyanion hole (OAH) forming residues; other site 1138383007501 trimer interface [polypeptide binding]; other site 1138383007502 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138383007503 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383007504 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383007505 short chain dehydrogenase; Provisional; Region: PRK07791 1138383007506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007507 NAD(P) binding site [chemical binding]; other site 1138383007508 active site 1138383007509 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383007510 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138383007511 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1138383007512 Subunit I/III interface [polypeptide binding]; other site 1138383007513 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1138383007514 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383007515 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383007516 putative active site [active] 1138383007517 putative substrate binding site [chemical binding]; other site 1138383007518 ATP binding site [chemical binding]; other site 1138383007519 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383007520 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383007521 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383007522 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383007523 active site 1138383007524 metal binding site [ion binding]; metal-binding site 1138383007525 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383007526 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383007527 NAD(P) binding site [chemical binding]; other site 1138383007528 catalytic residues [active] 1138383007529 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007530 classical (c) SDRs; Region: SDR_c; cd05233 1138383007531 NAD(P) binding site [chemical binding]; other site 1138383007532 active site 1138383007533 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383007534 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383007535 lipid-transfer protein; Provisional; Region: PRK07855 1138383007536 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007537 active site 1138383007538 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383007539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007541 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007542 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007543 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007544 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007545 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383007546 CoenzymeA binding site [chemical binding]; other site 1138383007547 subunit interaction site [polypeptide binding]; other site 1138383007548 PHB binding site; other site 1138383007549 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007550 classical (c) SDRs; Region: SDR_c; cd05233 1138383007551 NAD(P) binding site [chemical binding]; other site 1138383007552 active site 1138383007553 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383007554 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007555 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007556 acyl-activating enzyme (AAE) consensus motif; other site 1138383007557 acyl-activating enzyme (AAE) consensus motif; other site 1138383007558 AMP binding site [chemical binding]; other site 1138383007559 active site 1138383007560 CoA binding site [chemical binding]; other site 1138383007561 thiolase; Provisional; Region: PRK06158 1138383007562 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007563 active site 1138383007564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007565 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007566 active site 1138383007567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007569 active site 1138383007570 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138383007571 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383007572 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138383007573 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1138383007574 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383007575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138383007576 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1138383007577 Probable transposase; Region: OrfB_IS605; pfam01385 1138383007578 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1138383007579 lipid-transfer protein; Provisional; Region: PRK07855 1138383007580 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007581 active site 1138383007582 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383007583 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1138383007584 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138383007585 iron-sulfur cluster [ion binding]; other site 1138383007586 [2Fe-2S] cluster binding site [ion binding]; other site 1138383007587 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1138383007588 putative alpha subunit interface [polypeptide binding]; other site 1138383007589 putative active site [active] 1138383007590 putative substrate binding site [chemical binding]; other site 1138383007591 Fe binding site [ion binding]; other site 1138383007592 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1138383007593 inter-subunit interface; other site 1138383007594 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138383007595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007596 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383007597 acyl-activating enzyme (AAE) consensus motif; other site 1138383007598 acyl-activating enzyme (AAE) consensus motif; other site 1138383007599 putative AMP binding site [chemical binding]; other site 1138383007600 putative active site [active] 1138383007601 putative CoA binding site [chemical binding]; other site 1138383007602 CoA binding site [chemical binding]; other site 1138383007603 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383007604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007605 substrate binding site [chemical binding]; other site 1138383007606 oxyanion hole (OAH) forming residues; other site 1138383007607 trimer interface [polypeptide binding]; other site 1138383007608 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383007609 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1138383007610 NAD(P) binding site [chemical binding]; other site 1138383007611 catalytic residues [active] 1138383007612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007613 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007614 active site 1138383007615 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007616 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007617 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007618 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007619 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007620 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007621 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1138383007622 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383007623 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383007624 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007625 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007626 active site 1138383007627 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383007628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007629 substrate binding site [chemical binding]; other site 1138383007630 oxyanion hole (OAH) forming residues; other site 1138383007631 trimer interface [polypeptide binding]; other site 1138383007632 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1138383007633 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138383007634 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138383007635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007636 NAD(P) binding site [chemical binding]; other site 1138383007637 active site 1138383007638 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383007639 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138383007640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007641 substrate binding site [chemical binding]; other site 1138383007642 oxyanion hole (OAH) forming residues; other site 1138383007643 trimer interface [polypeptide binding]; other site 1138383007644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007646 active site 1138383007647 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383007648 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383007649 active site 2 [active] 1138383007650 active site 1 [active] 1138383007651 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007652 classical (c) SDRs; Region: SDR_c; cd05233 1138383007653 NAD(P) binding site [chemical binding]; other site 1138383007654 active site 1138383007655 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138383007656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007657 substrate binding site [chemical binding]; other site 1138383007658 oxyanion hole (OAH) forming residues; other site 1138383007659 trimer interface [polypeptide binding]; other site 1138383007660 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383007661 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007662 acyl-activating enzyme (AAE) consensus motif; other site 1138383007663 AMP binding site [chemical binding]; other site 1138383007664 active site 1138383007665 CoA binding site [chemical binding]; other site 1138383007666 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007668 active site 1138383007669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007671 active site 1138383007672 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007674 active site 1138383007675 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383007676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007678 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138383007679 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007680 Cytochrome P450; Region: p450; cl12078 1138383007681 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138383007682 choline dehydrogenase; Validated; Region: PRK02106 1138383007683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383007684 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138383007685 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383007686 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138383007687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007689 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007690 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007691 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007692 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007693 active site 1138383007694 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383007695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007699 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138383007700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007701 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007702 acyl-activating enzyme (AAE) consensus motif; other site 1138383007703 acyl-activating enzyme (AAE) consensus motif; other site 1138383007704 AMP binding site [chemical binding]; other site 1138383007705 active site 1138383007706 CoA binding site [chemical binding]; other site 1138383007707 lipid-transfer protein; Provisional; Region: PRK07855 1138383007708 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007709 active site 1138383007710 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138383007711 putative active site [active] 1138383007712 putative catalytic site [active] 1138383007713 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383007714 putative acyltransferase; Provisional; Region: PRK05790 1138383007715 dimer interface [polypeptide binding]; other site 1138383007716 active site 1138383007717 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383007718 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1138383007719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007721 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383007722 potential frameshift: common BLAST hit: gi|111223413|ref|YP_714207.1| ferredoxin reductase 1138383007723 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138383007724 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138383007725 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383007726 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138383007727 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383007728 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138383007729 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007730 Cytochrome P450; Region: p450; cl12078 1138383007731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007733 WHG domain; Region: WHG; pfam13305 1138383007734 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138383007735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007736 acyl-activating enzyme (AAE) consensus motif; other site 1138383007737 AMP binding site [chemical binding]; other site 1138383007738 active site 1138383007739 CoA binding site [chemical binding]; other site 1138383007740 lipid-transfer protein; Provisional; Region: PRK08256 1138383007741 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007742 active site 1138383007743 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007744 Cytochrome P450; Region: p450; cl12078 1138383007745 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383007746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007747 acyl-activating enzyme (AAE) consensus motif; other site 1138383007748 AMP binding site [chemical binding]; other site 1138383007749 active site 1138383007750 CoA binding site [chemical binding]; other site 1138383007751 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007752 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383007753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007754 active site 1138383007755 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383007756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007758 active site 1138383007759 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 1138383007760 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1138383007761 short chain dehydrogenase; Provisional; Region: PRK07791 1138383007762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007763 NAD(P) binding site [chemical binding]; other site 1138383007764 active site 1138383007765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007766 NAD(P) binding site [chemical binding]; other site 1138383007767 active site 1138383007768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383007769 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383007770 active site 1138383007771 metal binding site [ion binding]; metal-binding site 1138383007772 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007773 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007774 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138383007775 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138383007776 NAD binding site [chemical binding]; other site 1138383007777 catalytic residues [active] 1138383007778 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138383007779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007780 active site 1138383007781 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007782 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007784 active site 1138383007785 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138383007786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383007787 DNA-binding site [nucleotide binding]; DNA binding site 1138383007788 FCD domain; Region: FCD; pfam07729 1138383007789 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1138383007790 active site 2 [active] 1138383007791 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1138383007792 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1138383007793 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383007794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007795 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383007796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007797 substrate binding site [chemical binding]; other site 1138383007798 oxyanion hole (OAH) forming residues; other site 1138383007799 trimer interface [polypeptide binding]; other site 1138383007800 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138383007801 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383007802 active site 1138383007803 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383007804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007805 NAD(P) binding site [chemical binding]; other site 1138383007806 active site 1138383007807 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383007809 active site 1138383007810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383007811 active site 1138383007812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007813 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383007814 NAD(P) binding site [chemical binding]; other site 1138383007815 active site 1138383007816 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383007817 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383007818 substrate binding site [chemical binding]; other site 1138383007819 oxyanion hole (OAH) forming residues; other site 1138383007820 trimer interface [polypeptide binding]; other site 1138383007821 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383007822 classical (c) SDRs; Region: SDR_c; cd05233 1138383007823 NAD(P) binding site [chemical binding]; other site 1138383007824 active site 1138383007825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383007826 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1138383007827 NAD(P) binding site [chemical binding]; other site 1138383007828 active site 1138383007829 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383007830 Cytochrome P450; Region: p450; cl12078 1138383007831 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383007832 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1138383007833 catalytic triad [active] 1138383007834 conserved cis-peptide bond; other site 1138383007835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007837 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383007838 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383007839 [2Fe-2S] cluster binding site [ion binding]; other site 1138383007840 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383007841 hydrophobic ligand binding site; other site 1138383007842 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138383007843 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383007844 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138383007845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383007846 DNA-binding site [nucleotide binding]; DNA binding site 1138383007847 FCD domain; Region: FCD; pfam07729 1138383007848 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383007849 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383007850 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383007851 mce related protein; Region: MCE; pfam02470 1138383007852 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383007853 mce related protein; Region: MCE; pfam02470 1138383007854 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383007855 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138383007856 mce related protein; Region: MCE; pfam02470 1138383007857 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383007858 mce related protein; Region: MCE; pfam02470 1138383007859 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383007860 mce related protein; Region: MCE; pfam02470 1138383007861 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383007862 mce related protein; Region: MCE; pfam02470 1138383007863 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383007864 Permease; Region: Permease; pfam02405 1138383007865 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383007866 Permease; Region: Permease; pfam02405 1138383007867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383007868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383007869 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1138383007870 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1138383007871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383007872 Walker A motif; other site 1138383007873 ATP binding site [chemical binding]; other site 1138383007874 Walker B motif; other site 1138383007875 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383007876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383007877 non-specific DNA binding site [nucleotide binding]; other site 1138383007878 salt bridge; other site 1138383007879 sequence-specific DNA binding site [nucleotide binding]; other site 1138383007880 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138383007881 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138383007882 active site 1138383007883 catalytic residues [active] 1138383007884 DNA binding site [nucleotide binding] 1138383007885 Int/Topo IB signature motif; other site 1138383007886 putative transposase OrfB; Reviewed; Region: PHA02517 1138383007887 HTH-like domain; Region: HTH_21; pfam13276 1138383007888 Integrase core domain; Region: rve; pfam00665 1138383007889 Integrase core domain; Region: rve_3; pfam13683 1138383007890 GTP-binding protein Der; Reviewed; Region: PRK03003 1138383007891 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1138383007892 GTP/Mg2+ binding site [chemical binding]; other site 1138383007893 Switch I region; other site 1138383007894 G2 box; other site 1138383007895 Switch II region; other site 1138383007896 G3 box; other site 1138383007897 G4 box; other site 1138383007898 G5 box; other site 1138383007899 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1138383007900 G1 box; other site 1138383007901 GTP/Mg2+ binding site [chemical binding]; other site 1138383007902 Switch I region; other site 1138383007903 G2 box; other site 1138383007904 G3 box; other site 1138383007905 Switch II region; other site 1138383007906 G4 box; other site 1138383007907 G5 box; other site 1138383007908 cytidylate kinase; Provisional; Region: cmk; PRK00023 1138383007909 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1138383007910 CMP-binding site; other site 1138383007911 The sites determining sugar specificity; other site 1138383007912 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1138383007913 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138383007914 RNA binding surface [nucleotide binding]; other site 1138383007915 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1138383007916 active site 1138383007917 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1138383007918 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1138383007919 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138383007920 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138383007921 P loop; other site 1138383007922 Nucleotide binding site [chemical binding]; other site 1138383007923 DTAP/Switch II; other site 1138383007924 Switch I; other site 1138383007925 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138383007926 Magnesium ion binding site [ion binding]; other site 1138383007927 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138383007928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383007929 S-adenosylmethionine binding site [chemical binding]; other site 1138383007930 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1138383007931 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138383007932 active site 1138383007933 DNA binding site [nucleotide binding] 1138383007934 Int/Topo IB signature motif; other site 1138383007935 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1138383007936 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1138383007937 dimer interface [polypeptide binding]; other site 1138383007938 active site 1138383007939 ADP-ribose binding site [chemical binding]; other site 1138383007940 nudix motif; other site 1138383007941 metal binding site [ion binding]; metal-binding site 1138383007942 CTP synthetase; Validated; Region: pyrG; PRK05380 1138383007943 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1138383007944 Catalytic site [active] 1138383007945 active site 1138383007946 UTP binding site [chemical binding]; other site 1138383007947 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1138383007948 active site 1138383007949 putative oxyanion hole; other site 1138383007950 catalytic triad [active] 1138383007951 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1138383007952 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1138383007953 Thiamine pyrophosphokinase; Region: TPK; cl08415 1138383007954 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1138383007955 DNA repair protein RecN; Region: recN; TIGR00634 1138383007956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383007957 Walker A/P-loop; other site 1138383007958 ATP binding site [chemical binding]; other site 1138383007959 Q-loop/lid; other site 1138383007960 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1138383007961 ABC transporter signature motif; other site 1138383007962 Walker B; other site 1138383007963 D-loop; other site 1138383007964 H-loop/switch region; other site 1138383007965 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1138383007966 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1138383007967 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1138383007968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138383007969 RNA binding surface [nucleotide binding]; other site 1138383007970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383007971 S-adenosylmethionine binding site [chemical binding]; other site 1138383007972 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1138383007973 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1138383007974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383007975 active site 1138383007976 motif I; other site 1138383007977 motif II; other site 1138383007978 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1138383007979 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1138383007980 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383007981 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1138383007982 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1138383007983 active site 1138383007984 HIGH motif; other site 1138383007985 dimer interface [polypeptide binding]; other site 1138383007986 KMSKS motif; other site 1138383007987 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138383007988 RNA binding surface [nucleotide binding]; other site 1138383007989 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1138383007990 active site 1138383007991 DNA binding site [nucleotide binding] 1138383007992 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1138383007993 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138383007994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138383007995 Walker A/P-loop; other site 1138383007996 ATP binding site [chemical binding]; other site 1138383007997 Q-loop/lid; other site 1138383007998 ABC transporter signature motif; other site 1138383007999 Walker B; other site 1138383008000 D-loop; other site 1138383008001 H-loop/switch region; other site 1138383008002 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138383008003 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138383008004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383008005 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1138383008006 acyl-CoA synthetase; Validated; Region: PRK07868 1138383008007 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1138383008008 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383008009 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383008010 active site 1138383008011 CoA binding site [chemical binding]; other site 1138383008012 AMP binding site [chemical binding]; other site 1138383008013 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1138383008014 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138383008015 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138383008016 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138383008017 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1138383008018 short chain dehydrogenase; Provisional; Region: PRK07109 1138383008019 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1138383008020 putative NAD(P) binding site [chemical binding]; other site 1138383008021 active site 1138383008022 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 1138383008023 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138383008024 putative active site pocket [active] 1138383008025 putative metal binding site [ion binding]; other site 1138383008026 PAS fold; Region: PAS_3; pfam08447 1138383008027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138383008028 putative active site [active] 1138383008029 heme pocket [chemical binding]; other site 1138383008030 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383008031 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138383008032 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138383008033 ABC transporter; Region: ABC_tran_2; pfam12848 1138383008034 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138383008035 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383008036 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383008037 active site 1138383008038 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138383008039 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138383008040 malonyl-CoA binding site [chemical binding]; other site 1138383008041 dimer interface [polypeptide binding]; other site 1138383008042 active site 1138383008043 product binding site; other site 1138383008044 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383008045 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383008046 active site 1138383008047 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383008048 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383008049 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383008050 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383008051 active site 1138383008052 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383008053 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138383008054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383008055 Enoylreductase; Region: PKS_ER; smart00829 1138383008056 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138383008057 NAD(P) binding site [chemical binding]; other site 1138383008058 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138383008059 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383008060 putative NADP binding site [chemical binding]; other site 1138383008061 active site 1138383008062 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383008063 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138383008064 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138383008065 active site 1138383008066 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138383008067 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138383008068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383008069 Enoylreductase; Region: PKS_ER; smart00829 1138383008070 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138383008071 NAD(P) binding site [chemical binding]; other site 1138383008072 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138383008073 putative NADP binding site [chemical binding]; other site 1138383008074 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383008075 active site 1138383008076 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138383008077 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138383008078 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138383008079 malonyl-CoA binding site [chemical binding]; other site 1138383008080 dimer interface [polypeptide binding]; other site 1138383008081 active site 1138383008082 product binding site; other site 1138383008083 argininosuccinate lyase; Provisional; Region: PRK00855 1138383008084 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1138383008085 active sites [active] 1138383008086 tetramer interface [polypeptide binding]; other site 1138383008087 argininosuccinate synthase; Provisional; Region: PRK13820 1138383008088 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1138383008089 ANP binding site [chemical binding]; other site 1138383008090 Substrate Binding Site II [chemical binding]; other site 1138383008091 Substrate Binding Site I [chemical binding]; other site 1138383008092 arginine repressor; Provisional; Region: PRK03341 1138383008093 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1138383008094 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1138383008095 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1138383008096 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138383008097 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138383008098 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1138383008099 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138383008100 inhibitor-cofactor binding pocket; inhibition site 1138383008101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383008102 catalytic residue [active] 1138383008103 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1138383008104 feedback inhibition sensing region; other site 1138383008105 homohexameric interface [polypeptide binding]; other site 1138383008106 nucleotide binding site [chemical binding]; other site 1138383008107 N-acetyl-L-glutamate binding site [chemical binding]; other site 1138383008108 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1138383008109 heterotetramer interface [polypeptide binding]; other site 1138383008110 active site pocket [active] 1138383008111 cleavage site 1138383008112 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1138383008113 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138383008114 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1138383008115 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1138383008116 putative tRNA-binding site [nucleotide binding]; other site 1138383008117 B3/4 domain; Region: B3_4; pfam03483 1138383008118 tRNA synthetase B5 domain; Region: B5; smart00874 1138383008119 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1138383008120 dimer interface [polypeptide binding]; other site 1138383008121 motif 1; other site 1138383008122 motif 3; other site 1138383008123 motif 2; other site 1138383008124 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1138383008125 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1138383008126 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1138383008127 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1138383008128 dimer interface [polypeptide binding]; other site 1138383008129 motif 1; other site 1138383008130 active site 1138383008131 motif 2; other site 1138383008132 motif 3; other site 1138383008133 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383008134 cyclase homology domain; Region: CHD; cd07302 1138383008135 nucleotidyl binding site; other site 1138383008136 metal binding site [ion binding]; metal-binding site 1138383008137 dimer interface [polypeptide binding]; other site 1138383008138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138383008139 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138383008140 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1138383008141 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138383008142 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1138383008143 23S rRNA binding site [nucleotide binding]; other site 1138383008144 L21 binding site [polypeptide binding]; other site 1138383008145 L13 binding site [polypeptide binding]; other site 1138383008146 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1138383008147 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1138383008148 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1138383008149 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1138383008150 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1138383008151 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138383008152 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138383008153 dimer interface [polypeptide binding]; other site 1138383008154 putative anticodon binding site; other site 1138383008155 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138383008156 motif 1; other site 1138383008157 dimer interface [polypeptide binding]; other site 1138383008158 active site 1138383008159 motif 2; other site 1138383008160 motif 3; other site 1138383008161 Predicted esterase [General function prediction only]; Region: COG0627 1138383008162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383008163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383008164 hypothetical protein; Provisional; Region: PRK07877 1138383008165 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1138383008166 ATP binding site [chemical binding]; other site 1138383008167 substrate interface [chemical binding]; other site 1138383008168 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138383008169 dimer interface [polypeptide binding]; other site 1138383008170 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138383008171 Cytochrome P450; Region: p450; cl12078 1138383008172 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383008173 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138383008174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138383008175 metal binding site [ion binding]; metal-binding site 1138383008176 active site 1138383008177 I-site; other site 1138383008178 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138383008179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383008180 S-adenosylmethionine binding site [chemical binding]; other site 1138383008181 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138383008182 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1138383008183 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138383008184 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138383008185 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1138383008186 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383008187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138383008188 Ligand Binding Site [chemical binding]; other site 1138383008189 Predicted membrane protein [Function unknown]; Region: COG5305 1138383008190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383008191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138383008192 putative substrate translocation pore; other site 1138383008193 excinuclease ABC subunit B; Provisional; Region: PRK05298 1138383008194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383008195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383008196 nucleotide binding region [chemical binding]; other site 1138383008197 ATP-binding site [chemical binding]; other site 1138383008198 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1138383008199 UvrB/uvrC motif; Region: UVR; pfam02151 1138383008200 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383008201 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138383008202 active site 1138383008203 ATP binding site [chemical binding]; other site 1138383008204 substrate binding site [chemical binding]; other site 1138383008205 activation loop (A-loop); other site 1138383008206 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383008207 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383008208 phosphopeptide binding site; other site 1138383008209 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383008210 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383008211 phosphopeptide binding site; other site 1138383008212 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138383008213 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138383008214 Walker A/P-loop; other site 1138383008215 ATP binding site [chemical binding]; other site 1138383008216 Q-loop/lid; other site 1138383008217 ABC transporter signature motif; other site 1138383008218 Walker B; other site 1138383008219 D-loop; other site 1138383008220 H-loop/switch region; other site 1138383008221 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138383008222 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138383008223 Protein of unknown function (DUF402); Region: DUF402; cl00979 1138383008224 CheB methylesterase; Region: CheB_methylest; pfam01339 1138383008225 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1138383008226 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1138383008227 active site 1138383008228 DNA binding site [nucleotide binding] 1138383008229 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1138383008230 DNA binding site [nucleotide binding] 1138383008231 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1138383008232 nucleotide binding site [chemical binding]; other site 1138383008233 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138383008234 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 1138383008235 DNA binding site [nucleotide binding] 1138383008236 catalytic residue [active] 1138383008237 H2TH interface [polypeptide binding]; other site 1138383008238 putative catalytic residues [active] 1138383008239 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138383008240 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138383008241 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1138383008242 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1138383008243 CoA-binding site [chemical binding]; other site 1138383008244 ATP-binding [chemical binding]; other site 1138383008245 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1138383008246 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1138383008247 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1138383008248 RNA binding site [nucleotide binding]; other site 1138383008249 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1138383008250 RNA binding site [nucleotide binding]; other site 1138383008251 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138383008252 RNA binding site [nucleotide binding]; other site 1138383008253 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1138383008254 RNA binding site [nucleotide binding]; other site 1138383008255 potential frameshift: common BLAST hit: gi|118463937|ref|YP_882337.1| retinal pigment epithelial membrane protein 1138383008256 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1138383008257 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1138383008258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383008259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383008260 5'-3' exonuclease; Region: 53EXOc; smart00475 1138383008261 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138383008262 active site 1138383008263 metal binding site 1 [ion binding]; metal-binding site 1138383008264 putative 5' ssDNA interaction site; other site 1138383008265 metal binding site 3; metal-binding site 1138383008266 metal binding site 2 [ion binding]; metal-binding site 1138383008267 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138383008268 putative DNA binding site [nucleotide binding]; other site 1138383008269 putative metal binding site [ion binding]; other site 1138383008270 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1138383008271 DNA polymerase I; Provisional; Region: PRK05755 1138383008272 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1138383008273 active site 1138383008274 DNA binding site [nucleotide binding] 1138383008275 catalytic site [active] 1138383008276 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138383008277 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383008278 lipid-transfer protein; Provisional; Region: PRK06059 1138383008279 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383008280 active site 1138383008281 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1138383008282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383008283 active site 1138383008284 phosphorylation site [posttranslational modification] 1138383008285 intermolecular recognition site; other site 1138383008286 dimerization interface [polypeptide binding]; other site 1138383008287 ANTAR domain; Region: ANTAR; pfam03861 1138383008288 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138383008289 cyclase homology domain; Region: CHD; cd07302 1138383008290 nucleotidyl binding site; other site 1138383008291 metal binding site [ion binding]; metal-binding site 1138383008292 dimer interface [polypeptide binding]; other site 1138383008293 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1138383008294 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1138383008295 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1138383008296 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1138383008297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383008298 Walker A/P-loop; other site 1138383008299 ATP binding site [chemical binding]; other site 1138383008300 ABC transporter; Region: ABC_tran; pfam00005 1138383008301 Q-loop/lid; other site 1138383008302 ABC transporter signature motif; other site 1138383008303 Walker B; other site 1138383008304 D-loop; other site 1138383008305 H-loop/switch region; other site 1138383008306 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1138383008307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383008308 Walker A/P-loop; other site 1138383008309 ATP binding site [chemical binding]; other site 1138383008310 Q-loop/lid; other site 1138383008311 ABC transporter signature motif; other site 1138383008312 Walker B; other site 1138383008313 D-loop; other site 1138383008314 H-loop/switch region; other site 1138383008315 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138383008316 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138383008317 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138383008318 active site 1138383008319 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138383008320 catalytic triad [active] 1138383008321 dimer interface [polypeptide binding]; other site 1138383008322 pyruvate kinase; Provisional; Region: PRK06247 1138383008323 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1138383008324 domain interfaces; other site 1138383008325 active site 1138383008326 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1138383008327 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1138383008328 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1138383008329 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1138383008330 substrate binding site [chemical binding]; other site 1138383008331 active site 1138383008332 catalytic residues [active] 1138383008333 heterodimer interface [polypeptide binding]; other site 1138383008334 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1138383008335 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1138383008336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383008337 catalytic residue [active] 1138383008338 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1138383008339 active site 1138383008340 ribulose/triose binding site [chemical binding]; other site 1138383008341 phosphate binding site [ion binding]; other site 1138383008342 substrate (anthranilate) binding pocket [chemical binding]; other site 1138383008343 product (indole) binding pocket [chemical binding]; other site 1138383008344 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1138383008345 anthranilate synthase component I; Provisional; Region: PRK13571 1138383008346 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1138383008347 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138383008348 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138383008349 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138383008350 catalytic triad [active] 1138383008351 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1138383008352 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1138383008353 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1138383008354 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1138383008355 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138383008356 substrate binding site [chemical binding]; other site 1138383008357 glutamase interaction surface [polypeptide binding]; other site 1138383008358 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138383008359 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1138383008360 active site 1138383008361 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1138383008362 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138383008363 catalytic residues [active] 1138383008364 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1138383008365 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1138383008366 putative active site [active] 1138383008367 oxyanion strand; other site 1138383008368 catalytic triad [active] 1138383008369 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1138383008370 putative active site pocket [active] 1138383008371 4-fold oligomerization interface [polypeptide binding]; other site 1138383008372 metal binding residues [ion binding]; metal-binding site 1138383008373 3-fold/trimer interface [polypeptide binding]; other site 1138383008374 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1138383008375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383008376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383008377 homodimer interface [polypeptide binding]; other site 1138383008378 catalytic residue [active] 1138383008379 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1138383008380 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1138383008381 NAD binding site [chemical binding]; other site 1138383008382 dimerization interface [polypeptide binding]; other site 1138383008383 product binding site; other site 1138383008384 substrate binding site [chemical binding]; other site 1138383008385 zinc binding site [ion binding]; other site 1138383008386 catalytic residues [active] 1138383008387 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138383008388 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1138383008389 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1138383008390 dimerization interface [polypeptide binding]; other site 1138383008391 active site 1138383008392 L-aspartate oxidase; Provisional; Region: PRK07804 1138383008393 L-aspartate oxidase; Provisional; Region: PRK06175 1138383008394 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138383008395 quinolinate synthetase; Provisional; Region: PRK09375 1138383008396 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1138383008397 nudix motif; other site 1138383008398 Secretory lipase; Region: LIP; pfam03583 1138383008399 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1138383008400 biotin synthase; Validated; Region: PRK06256 1138383008401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383008402 FeS/SAM binding site; other site 1138383008403 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1138383008404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138383008405 dimerization interface [polypeptide binding]; other site 1138383008406 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138383008407 cyclase homology domain; Region: CHD; cd07302 1138383008408 nucleotidyl binding site; other site 1138383008409 metal binding site [ion binding]; metal-binding site 1138383008410 dimer interface [polypeptide binding]; other site 1138383008411 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138383008412 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138383008413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138383008414 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138383008415 ligand binding site [chemical binding]; other site 1138383008416 flexible hinge region; other site 1138383008417 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138383008418 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1138383008419 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1138383008420 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1138383008421 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1138383008422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383008423 catalytic residue [active] 1138383008424 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1138383008425 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138383008426 inhibitor-cofactor binding pocket; inhibition site 1138383008427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383008428 catalytic residue [active] 1138383008429 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138383008430 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138383008431 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383008432 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1138383008433 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1138383008434 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1138383008435 active site 1138383008436 catalytic site [active] 1138383008437 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1138383008438 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1138383008439 active site 1138383008440 catalytic site [active] 1138383008441 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1138383008442 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1138383008443 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1138383008444 catalytic site [active] 1138383008445 active site 1138383008446 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138383008447 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1138383008448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383008449 DNA-binding site [nucleotide binding]; DNA binding site 1138383008450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383008451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383008452 homodimer interface [polypeptide binding]; other site 1138383008453 catalytic residue [active] 1138383008454 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138383008455 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1138383008456 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138383008457 active site 1138383008458 threonine dehydratase; Validated; Region: PRK08639 1138383008459 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1138383008460 tetramer interface [polypeptide binding]; other site 1138383008461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383008462 catalytic residue [active] 1138383008463 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1138383008464 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383008465 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1138383008466 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138383008467 putative acyl-acceptor binding pocket; other site 1138383008468 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138383008469 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138383008470 acyl-activating enzyme (AAE) consensus motif; other site 1138383008471 putative AMP binding site [chemical binding]; other site 1138383008472 putative active site [active] 1138383008473 putative CoA binding site [chemical binding]; other site 1138383008474 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383008475 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138383008476 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1138383008477 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1138383008478 DNA binding residues [nucleotide binding] 1138383008479 putative dimer interface [polypeptide binding]; other site 1138383008480 putative metal binding residues [ion binding]; other site 1138383008481 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138383008482 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1138383008483 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1138383008484 active site 1138383008485 PHP Thumb interface [polypeptide binding]; other site 1138383008486 metal binding site [ion binding]; metal-binding site 1138383008487 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138383008488 generic binding surface II; other site 1138383008489 generic binding surface I; other site 1138383008490 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383008491 hydrophobic ligand binding site; other site 1138383008492 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138383008493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383008494 NAD(P) binding site [chemical binding]; other site 1138383008495 active site 1138383008496 classical (c) SDRs; Region: SDR_c; cd05233 1138383008497 NAD(P) binding site [chemical binding]; other site 1138383008498 active site 1138383008499 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1138383008500 apolar tunnel; other site 1138383008501 heme binding site [chemical binding]; other site 1138383008502 dimerization interface [polypeptide binding]; other site 1138383008503 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383008504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383008505 S-adenosylmethionine binding site [chemical binding]; other site 1138383008506 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1138383008507 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1138383008508 active site 1138383008509 lipoprotein signal peptidase; Provisional; Region: PRK14764 1138383008510 lipoprotein signal peptidase; Provisional; Region: PRK14787 1138383008511 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1138383008512 active site 1138383008513 homodimer interface [polypeptide binding]; other site 1138383008514 homotetramer interface [polypeptide binding]; other site 1138383008515 DNA polymerase IV; Provisional; Region: PRK03348 1138383008516 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138383008517 active site 1138383008518 DNA binding site [nucleotide binding] 1138383008519 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1138383008520 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138383008521 HIGH motif; other site 1138383008522 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138383008523 active site 1138383008524 KMSKS motif; other site 1138383008525 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1138383008526 tRNA binding surface [nucleotide binding]; other site 1138383008527 anticodon binding site; other site 1138383008528 Nitronate monooxygenase; Region: NMO; pfam03060 1138383008529 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383008530 FMN binding site [chemical binding]; other site 1138383008531 substrate binding site [chemical binding]; other site 1138383008532 putative catalytic residue [active] 1138383008533 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383008534 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383008535 Condensation domain; Region: Condensation; pfam00668 1138383008536 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008537 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383008538 acyl-activating enzyme (AAE) consensus motif; other site 1138383008539 AMP binding site [chemical binding]; other site 1138383008540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008541 Condensation domain; Region: Condensation; pfam00668 1138383008542 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008543 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008544 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008545 acyl-activating enzyme (AAE) consensus motif; other site 1138383008546 AMP binding site [chemical binding]; other site 1138383008547 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008548 peptide synthase; Provisional; Region: PRK12467 1138383008549 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008551 acyl-activating enzyme (AAE) consensus motif; other site 1138383008552 AMP binding site [chemical binding]; other site 1138383008553 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008554 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008555 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008556 acyl-activating enzyme (AAE) consensus motif; other site 1138383008557 AMP binding site [chemical binding]; other site 1138383008558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008559 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383008560 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008561 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008562 acyl-activating enzyme (AAE) consensus motif; other site 1138383008563 AMP binding site [chemical binding]; other site 1138383008564 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008565 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008566 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008567 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008568 acyl-activating enzyme (AAE) consensus motif; other site 1138383008569 AMP binding site [chemical binding]; other site 1138383008570 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008571 Condensation domain; Region: Condensation; pfam00668 1138383008572 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008573 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008574 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008575 acyl-activating enzyme (AAE) consensus motif; other site 1138383008576 AMP binding site [chemical binding]; other site 1138383008577 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008578 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138383008579 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138383008580 putative NAD(P) binding site [chemical binding]; other site 1138383008581 active site 1138383008582 putative substrate binding site [chemical binding]; other site 1138383008583 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008584 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383008585 acyl-activating enzyme (AAE) consensus motif; other site 1138383008586 AMP binding site [chemical binding]; other site 1138383008587 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008588 Condensation domain; Region: Condensation; pfam00668 1138383008589 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383008590 Condensation domain; Region: Condensation; pfam00668 1138383008591 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008592 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008593 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008594 acyl-activating enzyme (AAE) consensus motif; other site 1138383008595 AMP binding site [chemical binding]; other site 1138383008596 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008597 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138383008598 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138383008599 putative NAD(P) binding site [chemical binding]; other site 1138383008600 active site 1138383008601 putative substrate binding site [chemical binding]; other site 1138383008602 Condensation domain; Region: Condensation; pfam00668 1138383008603 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008604 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383008605 acyl-activating enzyme (AAE) consensus motif; other site 1138383008606 AMP binding site [chemical binding]; other site 1138383008607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008608 Condensation domain; Region: Condensation; pfam00668 1138383008609 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383008610 Condensation domain; Region: Condensation; pfam00668 1138383008611 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008612 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008614 acyl-activating enzyme (AAE) consensus motif; other site 1138383008615 AMP binding site [chemical binding]; other site 1138383008616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008617 Condensation domain; Region: Condensation; pfam00668 1138383008618 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383008619 Condensation domain; Region: Condensation; pfam00668 1138383008620 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008621 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008622 MbtH-like protein; Region: MbtH; pfam03621 1138383008623 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383008624 Transport protein; Region: actII; TIGR00833 1138383008625 Transport protein; Region: actII; TIGR00833 1138383008626 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1138383008627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383008628 Walker A/P-loop; other site 1138383008629 ATP binding site [chemical binding]; other site 1138383008630 Q-loop/lid; other site 1138383008631 ABC transporter signature motif; other site 1138383008632 Walker B; other site 1138383008633 D-loop; other site 1138383008634 H-loop/switch region; other site 1138383008635 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138383008636 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138383008637 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138383008638 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138383008639 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138383008640 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1138383008641 metal-binding site 1138383008642 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138383008643 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1138383008644 NADP binding site [chemical binding]; other site 1138383008645 active site 1138383008646 putative substrate binding site [chemical binding]; other site 1138383008647 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1138383008648 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1138383008649 NADP-binding site; other site 1138383008650 homotetramer interface [polypeptide binding]; other site 1138383008651 substrate binding site [chemical binding]; other site 1138383008652 homodimer interface [polypeptide binding]; other site 1138383008653 active site 1138383008654 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1138383008655 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1138383008656 substrate binding site; other site 1138383008657 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1138383008658 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1138383008659 NAD binding site [chemical binding]; other site 1138383008660 homotetramer interface [polypeptide binding]; other site 1138383008661 homodimer interface [polypeptide binding]; other site 1138383008662 substrate binding site [chemical binding]; other site 1138383008663 active site 1138383008664 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1138383008665 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1138383008666 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383008667 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1138383008668 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1138383008669 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1138383008670 inhibitor-cofactor binding pocket; inhibition site 1138383008671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383008672 catalytic residue [active] 1138383008673 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1138383008674 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1138383008675 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138383008676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138383008677 active site 1138383008678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383008679 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1138383008680 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1138383008681 NADP-binding site; other site 1138383008682 homotetramer interface [polypeptide binding]; other site 1138383008683 substrate binding site [chemical binding]; other site 1138383008684 homodimer interface [polypeptide binding]; other site 1138383008685 active site 1138383008686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383008687 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1138383008688 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138383008689 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138383008690 homodimer interface [polypeptide binding]; other site 1138383008691 active site 1138383008692 TDP-binding site; other site 1138383008693 acceptor substrate-binding pocket; other site 1138383008694 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138383008695 classical (c) SDRs; Region: SDR_c; cd05233 1138383008696 NAD(P) binding site [chemical binding]; other site 1138383008697 active site 1138383008698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383008699 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 1138383008700 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138383008701 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138383008702 homodimer interface [polypeptide binding]; other site 1138383008703 active site 1138383008704 TDP-binding site; other site 1138383008705 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138383008706 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138383008707 homodimer interface [polypeptide binding]; other site 1138383008708 active site 1138383008709 TDP-binding site; other site 1138383008710 acceptor substrate-binding pocket; other site 1138383008711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383008712 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383008713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383008714 NAD(P) binding site [chemical binding]; other site 1138383008715 active site 1138383008716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1138383008717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1138383008718 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383008719 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383008720 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383008721 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1138383008722 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1138383008723 Walker A; other site 1138383008724 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1138383008725 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1138383008726 active site 1138383008727 substrate binding site [chemical binding]; other site 1138383008728 coenzyme B12 binding site [chemical binding]; other site 1138383008729 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1138383008730 B12 binding site [chemical binding]; other site 1138383008731 cobalt ligand [ion binding]; other site 1138383008732 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1138383008733 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1138383008734 heterodimer interface [polypeptide binding]; other site 1138383008735 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1138383008736 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138383008737 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138383008738 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1138383008739 active site 1138383008740 substrate binding sites [chemical binding]; other site 1138383008741 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1138383008742 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138383008743 putative di-iron ligands [ion binding]; other site 1138383008744 Condensation domain; Region: Condensation; pfam00668 1138383008745 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008746 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138383008747 acyl-activating enzyme (AAE) consensus motif; other site 1138383008748 AMP binding site [chemical binding]; other site 1138383008749 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008750 Condensation domain; Region: Condensation; pfam00668 1138383008751 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383008752 Condensation domain; Region: Condensation; pfam00668 1138383008753 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008754 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008755 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138383008756 acyl-activating enzyme (AAE) consensus motif; other site 1138383008757 AMP binding site [chemical binding]; other site 1138383008758 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383008759 Condensation domain; Region: Condensation; pfam00668 1138383008760 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138383008761 Condensation domain; Region: Condensation; pfam00668 1138383008762 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138383008763 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138383008764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383008765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1138383008766 dimerization interface [polypeptide binding]; other site 1138383008767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383008768 dimer interface [polypeptide binding]; other site 1138383008769 phosphorylation site [posttranslational modification] 1138383008770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383008771 Mg2+ binding site [ion binding]; other site 1138383008772 G-X-G motif; other site 1138383008773 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383008774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383008775 active site 1138383008776 phosphorylation site [posttranslational modification] 1138383008777 intermolecular recognition site; other site 1138383008778 dimerization interface [polypeptide binding]; other site 1138383008779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383008780 DNA binding site [nucleotide binding] 1138383008781 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1138383008782 DoxX-like family; Region: DoxX_2; pfam13564 1138383008783 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138383008784 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138383008785 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1138383008786 ferrochelatase; Reviewed; Region: hemH; PRK00035 1138383008787 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1138383008788 C-terminal domain interface [polypeptide binding]; other site 1138383008789 active site 1138383008790 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1138383008791 active site 1138383008792 N-terminal domain interface [polypeptide binding]; other site 1138383008793 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1138383008794 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1138383008795 NAD binding site [chemical binding]; other site 1138383008796 homotetramer interface [polypeptide binding]; other site 1138383008797 homodimer interface [polypeptide binding]; other site 1138383008798 substrate binding site [chemical binding]; other site 1138383008799 active site 1138383008800 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1138383008801 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138383008802 NAD(P) binding site [chemical binding]; other site 1138383008803 homotetramer interface [polypeptide binding]; other site 1138383008804 homodimer interface [polypeptide binding]; other site 1138383008805 active site 1138383008806 hypothetical protein; Provisional; Region: PRK13685 1138383008807 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1138383008808 metal ion-dependent adhesion site (MIDAS); other site 1138383008809 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138383008810 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138383008811 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138383008812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383008813 Walker A motif; other site 1138383008814 ATP binding site [chemical binding]; other site 1138383008815 Walker B motif; other site 1138383008816 arginine finger; other site 1138383008817 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138383008818 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138383008819 potential frameshift: common BLAST hit: gi|118465185|ref|YP_882483.1| invasion protein 1138383008820 NlpC/P60 family; Region: NLPC_P60; cl17555 1138383008821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1138383008822 aconitate hydratase; Validated; Region: PRK09277 1138383008823 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138383008824 substrate binding site [chemical binding]; other site 1138383008825 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138383008826 ligand binding site [chemical binding]; other site 1138383008827 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1138383008828 substrate binding site [chemical binding]; other site 1138383008829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383008830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383008831 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138383008832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383008833 Walker A/P-loop; other site 1138383008834 ATP binding site [chemical binding]; other site 1138383008835 Q-loop/lid; other site 1138383008836 ABC transporter signature motif; other site 1138383008837 Walker B; other site 1138383008838 D-loop; other site 1138383008839 H-loop/switch region; other site 1138383008840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138383008841 enoyl-CoA hydratase; Provisional; Region: PRK05864 1138383008842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383008843 substrate binding site [chemical binding]; other site 1138383008844 oxyanion hole (OAH) forming residues; other site 1138383008845 trimer interface [polypeptide binding]; other site 1138383008846 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138383008847 catalytic residues [active] 1138383008848 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138383008849 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138383008850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383008851 active site 1138383008852 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138383008853 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138383008854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383008855 NAD(P) binding site [chemical binding]; other site 1138383008856 active site 1138383008857 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1138383008858 homotrimer interaction site [polypeptide binding]; other site 1138383008859 putative active site [active] 1138383008860 Cupin domain; Region: Cupin_2; pfam07883 1138383008861 Transposase; Region: HTH_Tnp_1; cl17663 1138383008862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138383008863 putative transposase OrfB; Reviewed; Region: PHA02517 1138383008864 HTH-like domain; Region: HTH_21; pfam13276 1138383008865 Integrase core domain; Region: rve; pfam00665 1138383008866 Integrase core domain; Region: rve_3; cl15866 1138383008867 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1138383008868 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383008869 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1138383008870 dimer interface [polypeptide binding]; other site 1138383008871 active site 1138383008872 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138383008873 classical (c) SDRs; Region: SDR_c; cd05233 1138383008874 NAD(P) binding site [chemical binding]; other site 1138383008875 active site 1138383008876 Transport protein; Region: actII; TIGR00833 1138383008877 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383008878 O-methyltransferase; Region: Methyltransf_2; pfam00891 1138383008879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383008880 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138383008881 putative substrate translocation pore; other site 1138383008882 FMN binding site [chemical binding]; other site 1138383008883 Nitroreductase family; Region: Nitroreductase; pfam00881 1138383008884 dimer interface [polypeptide binding]; other site 1138383008885 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1138383008886 homotrimer interaction site [polypeptide binding]; other site 1138383008887 putative active site [active] 1138383008888 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138383008889 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138383008890 putative NAD(P) binding site [chemical binding]; other site 1138383008891 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1138383008892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383008893 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383008894 Cupin domain; Region: Cupin_2; cl17218 1138383008895 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138383008896 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138383008897 putative NAD(P) binding site [chemical binding]; other site 1138383008898 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383008899 PPE family; Region: PPE; pfam00823 1138383008900 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383008901 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383008902 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138383008903 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1138383008904 GAF domain; Region: GAF; cl17456 1138383008905 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1138383008906 DNA-binding interface [nucleotide binding]; DNA binding site 1138383008907 AAA ATPase domain; Region: AAA_16; pfam13191 1138383008908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383008909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383008910 DNA binding residues [nucleotide binding] 1138383008911 dimerization interface [polypeptide binding]; other site 1138383008912 AAA ATPase domain; Region: AAA_16; pfam13191 1138383008913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383008914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383008915 DNA binding residues [nucleotide binding] 1138383008916 dimerization interface [polypeptide binding]; other site 1138383008917 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1138383008918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383008919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383008920 DNA binding residues [nucleotide binding] 1138383008921 dimerization interface [polypeptide binding]; other site 1138383008922 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1138383008923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383008924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383008925 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383008926 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1138383008927 putative active site [active] 1138383008928 transaldolase; Provisional; Region: PRK03903 1138383008929 catalytic residue [active] 1138383008930 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138383008931 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1138383008932 Moco binding site; other site 1138383008933 metal coordination site [ion binding]; other site 1138383008934 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138383008935 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 1138383008936 FAD binding pocket [chemical binding]; other site 1138383008937 FAD binding motif [chemical binding]; other site 1138383008938 phosphate binding motif [ion binding]; other site 1138383008939 beta-alpha-beta structure motif; other site 1138383008940 NAD binding pocket [chemical binding]; other site 1138383008941 DNL zinc finger; Region: zf-DNL; pfam05180 1138383008942 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1138383008943 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138383008944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138383008945 Protein of unknown function, DUF417; Region: DUF417; cl01162 1138383008946 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138383008947 classical (c) SDRs; Region: SDR_c; cd05233 1138383008948 NAD(P) binding site [chemical binding]; other site 1138383008949 active site 1138383008950 SelR domain; Region: SelR; pfam01641 1138383008951 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1138383008952 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1138383008953 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1138383008954 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1138383008955 D-pathway; other site 1138383008956 Putative ubiquinol binding site [chemical binding]; other site 1138383008957 Low-spin heme (heme b) binding site [chemical binding]; other site 1138383008958 Putative water exit pathway; other site 1138383008959 Binuclear center (heme o3/CuB) [ion binding]; other site 1138383008960 K-pathway; other site 1138383008961 Putative proton exit pathway; other site 1138383008962 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138383008963 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383008964 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383008965 Predicted membrane protein [Function unknown]; Region: COG2323 1138383008966 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1138383008967 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1138383008968 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1138383008969 trimerization site [polypeptide binding]; other site 1138383008970 active site 1138383008971 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138383008972 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1138383008973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383008974 catalytic residue [active] 1138383008975 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1138383008976 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1138383008977 Walker A/P-loop; other site 1138383008978 ATP binding site [chemical binding]; other site 1138383008979 Q-loop/lid; other site 1138383008980 ABC transporter signature motif; other site 1138383008981 Walker B; other site 1138383008982 D-loop; other site 1138383008983 H-loop/switch region; other site 1138383008984 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1138383008985 FeS assembly protein SufD; Region: sufD; TIGR01981 1138383008986 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1138383008987 FeS assembly protein SufB; Region: sufB; TIGR01980 1138383008988 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138383008989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383008990 putative DNA binding site [nucleotide binding]; other site 1138383008991 putative Zn2+ binding site [ion binding]; other site 1138383008992 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138383008993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138383008994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138383008995 Walker A/P-loop; other site 1138383008996 ATP binding site [chemical binding]; other site 1138383008997 Q-loop/lid; other site 1138383008998 ABC transporter signature motif; other site 1138383008999 Walker B; other site 1138383009000 D-loop; other site 1138383009001 H-loop/switch region; other site 1138383009002 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138383009003 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1138383009004 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1138383009005 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1138383009006 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1138383009007 NADP binding site [chemical binding]; other site 1138383009008 dimer interface [polypeptide binding]; other site 1138383009009 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1138383009010 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138383009011 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1138383009012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1138383009013 TPP-binding site [chemical binding]; other site 1138383009014 dimer interface [polypeptide binding]; other site 1138383009015 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138383009016 PYR/PP interface [polypeptide binding]; other site 1138383009017 dimer interface [polypeptide binding]; other site 1138383009018 TPP binding site [chemical binding]; other site 1138383009019 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138383009020 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1138383009021 putative active site [active] 1138383009022 transaldolase; Provisional; Region: PRK03903 1138383009023 catalytic residue [active] 1138383009024 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1138383009025 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138383009026 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138383009027 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1138383009028 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1138383009029 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1138383009030 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1138383009031 putative active site [active] 1138383009032 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1138383009033 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1138383009034 putative active site [active] 1138383009035 Zn binding site [ion binding]; other site 1138383009036 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383009037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383009038 active site 1138383009039 catalytic tetrad [active] 1138383009040 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1138383009041 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1138383009042 Preprotein translocase SecG subunit; Region: SecG; cl09123 1138383009043 triosephosphate isomerase; Provisional; Region: PRK14567 1138383009044 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1138383009045 substrate binding site [chemical binding]; other site 1138383009046 dimer interface [polypeptide binding]; other site 1138383009047 catalytic triad [active] 1138383009048 Phosphoglycerate kinase; Region: PGK; pfam00162 1138383009049 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1138383009050 substrate binding site [chemical binding]; other site 1138383009051 hinge regions; other site 1138383009052 ADP binding site [chemical binding]; other site 1138383009053 catalytic site [active] 1138383009054 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1138383009055 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1138383009056 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1138383009057 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138383009058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383009059 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138383009060 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383009061 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383009062 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138383009063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383009064 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138383009065 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383009066 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138383009067 putative acyl-acceptor binding pocket; other site 1138383009068 acyl-CoA synthetase; Provisional; Region: PRK13382 1138383009069 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383009070 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383009071 acyl-activating enzyme (AAE) consensus motif; other site 1138383009072 putative AMP binding site [chemical binding]; other site 1138383009073 putative active site [active] 1138383009074 putative CoA binding site [chemical binding]; other site 1138383009075 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138383009076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383009077 substrate binding pocket [chemical binding]; other site 1138383009078 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383009079 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383009080 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383009081 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383009082 active site 1138383009083 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383009084 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383009085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1138383009086 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1138383009087 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1138383009088 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1138383009089 phosphate binding site [ion binding]; other site 1138383009090 putative substrate binding pocket [chemical binding]; other site 1138383009091 dimer interface [polypeptide binding]; other site 1138383009092 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1138383009093 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1138383009094 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138383009095 GIY-YIG motif/motif A; other site 1138383009096 active site 1138383009097 catalytic site [active] 1138383009098 putative DNA binding site [nucleotide binding]; other site 1138383009099 metal binding site [ion binding]; metal-binding site 1138383009100 UvrB/uvrC motif; Region: UVR; pfam02151 1138383009101 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1138383009102 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138383009103 Cupin superfamily protein; Region: Cupin_4; pfam08007 1138383009104 Cupin-like domain; Region: Cupin_8; pfam13621 1138383009105 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383009106 PPE family; Region: PPE; pfam00823 1138383009107 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138383009108 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1138383009109 homopentamer interface [polypeptide binding]; other site 1138383009110 active site 1138383009111 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1138383009112 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1138383009113 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1138383009114 dimerization interface [polypeptide binding]; other site 1138383009115 active site 1138383009116 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1138383009117 Lumazine binding domain; Region: Lum_binding; pfam00677 1138383009118 Lumazine binding domain; Region: Lum_binding; pfam00677 1138383009119 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1138383009120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383009121 putative substrate translocation pore; other site 1138383009122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383009123 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1138383009124 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1138383009125 catalytic motif [active] 1138383009126 Zn binding site [ion binding]; other site 1138383009127 RibD C-terminal domain; Region: RibD_C; pfam01872 1138383009128 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1138383009129 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1138383009130 substrate binding site [chemical binding]; other site 1138383009131 hexamer interface [polypeptide binding]; other site 1138383009132 metal binding site [ion binding]; metal-binding site 1138383009133 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1138383009134 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1138383009135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383009136 S-adenosylmethionine binding site [chemical binding]; other site 1138383009137 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1138383009138 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1138383009139 putative active site [active] 1138383009140 substrate binding site [chemical binding]; other site 1138383009141 putative cosubstrate binding site; other site 1138383009142 catalytic site [active] 1138383009143 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1138383009144 substrate binding site [chemical binding]; other site 1138383009145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383009146 S-adenosylmethionine binding site [chemical binding]; other site 1138383009147 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383009148 MarR family; Region: MarR; pfam01047 1138383009149 primosome assembly protein PriA; Provisional; Region: PRK14873 1138383009150 Predicted membrane protein [Function unknown]; Region: COG3714 1138383009151 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383009152 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383009153 substrate binding pocket [chemical binding]; other site 1138383009154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383009155 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383009156 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138383009157 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1138383009158 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1138383009159 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1138383009160 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1138383009161 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1138383009162 Flavoprotein; Region: Flavoprotein; pfam02441 1138383009163 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1138383009164 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1138383009165 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1138383009166 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1138383009167 catalytic site [active] 1138383009168 G-X2-G-X-G-K; other site 1138383009169 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1138383009170 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383009171 DNA binding residues [nucleotide binding] 1138383009172 TOBE domain; Region: TOBE; cl01440 1138383009173 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1138383009174 active site 1138383009175 dimer interface [polypeptide binding]; other site 1138383009176 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1138383009177 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138383009178 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383009179 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1138383009180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138383009181 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383009182 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1138383009183 IMP binding site; other site 1138383009184 dimer interface [polypeptide binding]; other site 1138383009185 interdomain contacts; other site 1138383009186 partial ornithine binding site; other site 1138383009187 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1138383009188 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1138383009189 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1138383009190 catalytic site [active] 1138383009191 subunit interface [polypeptide binding]; other site 1138383009192 dihydroorotase; Validated; Region: pyrC; PRK09357 1138383009193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383009194 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1138383009195 active site 1138383009196 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138383009197 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1138383009198 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138383009199 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1138383009200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383009201 active site 1138383009202 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383009203 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383009204 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138383009205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138383009206 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1138383009207 L-aspartate oxidase; Provisional; Region: PRK06175 1138383009208 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138383009209 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138383009210 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138383009211 Walker A/P-loop; other site 1138383009212 ATP binding site [chemical binding]; other site 1138383009213 Q-loop/lid; other site 1138383009214 ABC transporter signature motif; other site 1138383009215 Walker B; other site 1138383009216 D-loop; other site 1138383009217 H-loop/switch region; other site 1138383009218 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138383009219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383009220 dimer interface [polypeptide binding]; other site 1138383009221 conserved gate region; other site 1138383009222 putative PBP binding loops; other site 1138383009223 ABC-ATPase subunit interface; other site 1138383009224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1138383009225 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1138383009226 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1138383009227 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138383009228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383009229 DNA-binding site [nucleotide binding]; DNA binding site 1138383009230 UTRA domain; Region: UTRA; pfam07702 1138383009231 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1138383009232 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383009233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383009234 catalytic residue [active] 1138383009235 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1138383009236 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1138383009237 elongation factor P; Validated; Region: PRK00529 1138383009238 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1138383009239 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1138383009240 RNA binding site [nucleotide binding]; other site 1138383009241 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1138383009242 RNA binding site [nucleotide binding]; other site 1138383009243 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138383009244 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138383009245 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138383009246 active site 1138383009247 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1138383009248 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1138383009249 trimer interface [polypeptide binding]; other site 1138383009250 active site 1138383009251 dimer interface [polypeptide binding]; other site 1138383009252 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1138383009253 active site 1138383009254 dimer interface [polypeptide binding]; other site 1138383009255 metal binding site [ion binding]; metal-binding site 1138383009256 shikimate kinase; Reviewed; Region: aroK; PRK00131 1138383009257 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1138383009258 ADP binding site [chemical binding]; other site 1138383009259 magnesium binding site [ion binding]; other site 1138383009260 putative shikimate binding site; other site 1138383009261 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1138383009262 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 1138383009263 Tetramer interface [polypeptide binding]; other site 1138383009264 active site 1138383009265 FMN-binding site [chemical binding]; other site 1138383009266 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1138383009267 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1138383009268 active site 1138383009269 dimer interface [polypeptide binding]; other site 1138383009270 non-prolyl cis peptide bond; other site 1138383009271 insertion regions; other site 1138383009272 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1138383009273 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1138383009274 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1138383009275 shikimate binding site; other site 1138383009276 NAD(P) binding site [chemical binding]; other site 1138383009277 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1138383009278 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1138383009279 dimerization interface [polypeptide binding]; other site 1138383009280 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1138383009281 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1138383009282 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1138383009283 motif 1; other site 1138383009284 active site 1138383009285 motif 2; other site 1138383009286 motif 3; other site 1138383009287 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1138383009288 DHHA1 domain; Region: DHHA1; pfam02272 1138383009289 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1138383009290 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1138383009291 recombination factor protein RarA; Reviewed; Region: PRK13342 1138383009292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383009293 Walker A motif; other site 1138383009294 ATP binding site [chemical binding]; other site 1138383009295 Walker B motif; other site 1138383009296 arginine finger; other site 1138383009297 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1138383009298 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1138383009299 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1138383009300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138383009301 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138383009302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1138383009303 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1138383009304 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138383009305 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138383009306 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1138383009307 Protein of unknown function (DUF419); Region: DUF419; cl15265 1138383009308 potential frameshift: common BLAST hit: gi|340627588|ref|YP_004746040.1| putative transmembrane alanine and valine and leucine rich protein 1138383009309 Predicted membrane protein [Function unknown]; Region: COG4129 1138383009310 Predicted membrane protein [Function unknown]; Region: COG4129 1138383009311 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383009312 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1138383009313 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1138383009314 dimer interface [polypeptide binding]; other site 1138383009315 anticodon binding site; other site 1138383009316 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1138383009317 homodimer interface [polypeptide binding]; other site 1138383009318 motif 1; other site 1138383009319 active site 1138383009320 motif 2; other site 1138383009321 GAD domain; Region: GAD; pfam02938 1138383009322 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138383009323 active site 1138383009324 motif 3; other site 1138383009325 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1138383009326 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1138383009327 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1138383009328 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138383009329 putative hydrophobic ligand binding site [chemical binding]; other site 1138383009330 protein interface [polypeptide binding]; other site 1138383009331 gate; other site 1138383009332 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1138383009333 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138383009334 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1138383009335 inhibitor site; inhibition site 1138383009336 active site 1138383009337 dimer interface [polypeptide binding]; other site 1138383009338 catalytic residue [active] 1138383009339 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1138383009340 intersubunit interface [polypeptide binding]; other site 1138383009341 active site 1138383009342 Zn2+ binding site [ion binding]; other site 1138383009343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383009344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383009345 non-specific DNA binding site [nucleotide binding]; other site 1138383009346 salt bridge; other site 1138383009347 sequence-specific DNA binding site [nucleotide binding]; other site 1138383009348 Cupin domain; Region: Cupin_2; pfam07883 1138383009349 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138383009350 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138383009351 active site 1138383009352 metal binding site [ion binding]; metal-binding site 1138383009353 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1138383009354 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138383009355 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383009356 hydrophobic ligand binding site; other site 1138383009357 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383009358 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383009359 active site 1138383009360 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1138383009361 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1138383009362 dimer interface [polypeptide binding]; other site 1138383009363 motif 1; other site 1138383009364 active site 1138383009365 motif 2; other site 1138383009366 motif 3; other site 1138383009367 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1138383009368 anticodon binding site; other site 1138383009369 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138383009370 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138383009371 active site 1138383009372 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1138383009373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138383009374 Zn2+ binding site [ion binding]; other site 1138383009375 Mg2+ binding site [ion binding]; other site 1138383009376 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1138383009377 synthetase active site [active] 1138383009378 NTP binding site [chemical binding]; other site 1138383009379 metal binding site [ion binding]; metal-binding site 1138383009380 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1138383009381 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1138383009382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383009383 active site 1138383009384 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138383009385 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138383009386 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1138383009387 Protein export membrane protein; Region: SecD_SecF; pfam02355 1138383009388 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1138383009389 Protein export membrane protein; Region: SecD_SecF; cl14618 1138383009390 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1138383009391 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1138383009392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138383009393 inhibitor-cofactor binding pocket; inhibition site 1138383009394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383009395 catalytic residue [active] 1138383009396 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138383009397 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383009398 acyl-activating enzyme (AAE) consensus motif; other site 1138383009399 AMP binding site [chemical binding]; other site 1138383009400 active site 1138383009401 CoA binding site [chemical binding]; other site 1138383009402 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383009403 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138383009404 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138383009405 putative NAD(P) binding site [chemical binding]; other site 1138383009406 active site 1138383009407 putative substrate binding site [chemical binding]; other site 1138383009408 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1138383009409 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1138383009410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383009411 Walker A motif; other site 1138383009412 ATP binding site [chemical binding]; other site 1138383009413 Walker B motif; other site 1138383009414 arginine finger; other site 1138383009415 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1138383009416 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1138383009417 RuvA N terminal domain; Region: RuvA_N; pfam01330 1138383009418 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1138383009419 active site 1138383009420 putative DNA-binding cleft [nucleotide binding]; other site 1138383009421 dimer interface [polypeptide binding]; other site 1138383009422 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1138383009423 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1138383009424 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1138383009425 spermidine synthase; Provisional; Region: PRK03612 1138383009426 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1138383009427 hypothetical protein; Validated; Region: PRK00110 1138383009428 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138383009429 Integrase core domain; Region: rve; pfam00665 1138383009430 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138383009431 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1138383009432 predicted active site [active] 1138383009433 catalytic triad [active] 1138383009434 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138383009435 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138383009436 active site 1138383009437 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138383009438 catalytic triad [active] 1138383009439 dimer interface [polypeptide binding]; other site 1138383009440 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1138383009441 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1138383009442 active site 1138383009443 multimer interface [polypeptide binding]; other site 1138383009444 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1138383009445 nudix motif; other site 1138383009446 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383009447 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1138383009448 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1138383009449 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1138383009450 putative acyl-acceptor binding pocket; other site 1138383009451 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138383009452 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1138383009453 nucleotide binding site/active site [active] 1138383009454 HIT family signature motif; other site 1138383009455 catalytic residue [active] 1138383009456 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1138383009457 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1138383009458 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1138383009459 active site 1138383009460 dimer interface [polypeptide binding]; other site 1138383009461 motif 1; other site 1138383009462 motif 2; other site 1138383009463 motif 3; other site 1138383009464 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1138383009465 anticodon binding site; other site 1138383009466 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1138383009467 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383009468 CoenzymeA binding site [chemical binding]; other site 1138383009469 subunit interaction site [polypeptide binding]; other site 1138383009470 PHB binding site; other site 1138383009471 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383009472 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383009473 active site 1138383009474 catalytic tetrad [active] 1138383009475 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1138383009476 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138383009477 putative DNA binding site [nucleotide binding]; other site 1138383009478 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138383009479 putative Zn2+ binding site [ion binding]; other site 1138383009480 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383009481 FMN binding site [chemical binding]; other site 1138383009482 substrate binding site [chemical binding]; other site 1138383009483 putative catalytic residue [active] 1138383009484 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1138383009485 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138383009486 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138383009487 putative DNA binding site [nucleotide binding]; other site 1138383009488 putative Zn2+ binding site [ion binding]; other site 1138383009489 Ferredoxin [Energy production and conversion]; Region: COG1146 1138383009490 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383009491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383009492 S-adenosylmethionine binding site [chemical binding]; other site 1138383009493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383009494 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1138383009495 tetramer interface [polypeptide binding]; other site 1138383009496 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1138383009497 active site 1138383009498 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1138383009499 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1138383009500 active site 1138383009501 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383009502 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1138383009503 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138383009504 iron-sulfur cluster [ion binding]; other site 1138383009505 [2Fe-2S] cluster binding site [ion binding]; other site 1138383009506 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 1138383009507 alpha subunit interaction site [polypeptide binding]; other site 1138383009508 beta subunit interaction site [polypeptide binding]; other site 1138383009509 iron-sulfur cluster [ion binding]; other site 1138383009510 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1138383009511 beta subunit interface [polypeptide binding]; other site 1138383009512 alpha subunit interface [polypeptide binding]; other site 1138383009513 active site 1138383009514 substrate binding site [chemical binding]; other site 1138383009515 Fe binding site [ion binding]; other site 1138383009516 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1138383009517 inter-subunit interface; other site 1138383009518 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1138383009519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383009520 NAD(P) binding site [chemical binding]; other site 1138383009521 active site 1138383009522 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1138383009523 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138383009524 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383009525 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138383009526 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138383009527 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138383009528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383009529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383009530 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383009531 anti sigma factor interaction site; other site 1138383009532 regulatory phosphorylation site [posttranslational modification]; other site 1138383009533 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1138383009534 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1138383009535 Predicted permeases [General function prediction only]; Region: COG0730 1138383009536 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1138383009537 putative heme binding pocket [chemical binding]; other site 1138383009538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383009539 classical (c) SDRs; Region: SDR_c; cd05233 1138383009540 NAD(P) binding site [chemical binding]; other site 1138383009541 active site 1138383009542 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138383009543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383009544 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383009545 acyl-activating enzyme (AAE) consensus motif; other site 1138383009546 putative AMP binding site [chemical binding]; other site 1138383009547 putative active site [active] 1138383009548 putative CoA binding site [chemical binding]; other site 1138383009549 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138383009550 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138383009551 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383009552 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383009553 substrate binding site [chemical binding]; other site 1138383009554 oxyanion hole (OAH) forming residues; other site 1138383009555 trimer interface [polypeptide binding]; other site 1138383009556 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383009557 hydrophobic ligand binding site; other site 1138383009558 Helix-turn-helix domain; Region: HTH_17; cl17695 1138383009559 putative transposase OrfB; Reviewed; Region: PHA02517 1138383009560 HTH-like domain; Region: HTH_21; pfam13276 1138383009561 Integrase core domain; Region: rve; pfam00665 1138383009562 Integrase core domain; Region: rve_3; pfam13683 1138383009563 Transposase; Region: HTH_Tnp_1; cl17663 1138383009564 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383009565 putative transposase OrfB; Reviewed; Region: PHA02517 1138383009566 HTH-like domain; Region: HTH_21; pfam13276 1138383009567 Integrase core domain; Region: rve; pfam00665 1138383009568 Integrase core domain; Region: rve_3; cl15866 1138383009569 AAA domain; Region: AAA_25; pfam13481 1138383009570 Helix-turn-helix domain; Region: HTH_17; cl17695 1138383009571 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138383009572 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138383009573 active site 1138383009574 catalytic residues [active] 1138383009575 DNA binding site [nucleotide binding] 1138383009576 Int/Topo IB signature motif; other site 1138383009577 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138383009578 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383009579 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383009580 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1138383009581 classical (c) SDRs; Region: SDR_c; cd05233 1138383009582 NAD(P) binding site [chemical binding]; other site 1138383009583 active site 1138383009584 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383009585 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138383009586 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1138383009587 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383009588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383009589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383009590 short chain dehydrogenase; Provisional; Region: PRK12827 1138383009591 classical (c) SDRs; Region: SDR_c; cd05233 1138383009592 NAD(P) binding site [chemical binding]; other site 1138383009593 active site 1138383009594 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383009595 classical (c) SDRs; Region: SDR_c; cd05233 1138383009596 NAD(P) binding site [chemical binding]; other site 1138383009597 active site 1138383009598 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138383009599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138383009600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383009601 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383009602 NAD(P) binding site [chemical binding]; other site 1138383009603 catalytic residues [active] 1138383009604 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138383009605 Cation efflux family; Region: Cation_efflux; cl00316 1138383009606 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383009607 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383009608 Clp amino terminal domain; Region: Clp_N; pfam02861 1138383009609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383009610 Coenzyme A binding pocket [chemical binding]; other site 1138383009611 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1138383009612 hypothetical protein; Provisional; Region: PRK14059 1138383009613 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1138383009614 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383009615 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138383009616 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138383009617 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1138383009618 SelR domain; Region: SelR; pfam01641 1138383009619 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383009620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383009621 S-adenosylmethionine binding site [chemical binding]; other site 1138383009622 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1138383009623 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1138383009624 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383009625 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1138383009626 substrate binding site [chemical binding]; other site 1138383009627 active site 1138383009628 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383009629 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383009630 substrate binding site [chemical binding]; other site 1138383009631 oxyanion hole (OAH) forming residues; other site 1138383009632 trimer interface [polypeptide binding]; other site 1138383009633 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1138383009634 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1138383009635 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1138383009636 catalytic site [active] 1138383009637 putative active site [active] 1138383009638 putative substrate binding site [chemical binding]; other site 1138383009639 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1138383009640 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1138383009641 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1138383009642 TPP-binding site; other site 1138383009643 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138383009644 PYR/PP interface [polypeptide binding]; other site 1138383009645 dimer interface [polypeptide binding]; other site 1138383009646 TPP binding site [chemical binding]; other site 1138383009647 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138383009648 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138383009649 FOG: CBS domain [General function prediction only]; Region: COG0517 1138383009650 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1138383009651 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1138383009652 transmembrane helices; other site 1138383009653 TRAM domain; Region: TRAM; pfam01938 1138383009654 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1138383009655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383009656 NAD(P) binding site [chemical binding]; other site 1138383009657 active site 1138383009658 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138383009659 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138383009660 TrkA-N domain; Region: TrkA_N; pfam02254 1138383009661 TrkA-C domain; Region: TrkA_C; pfam02080 1138383009662 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138383009663 TrkA-N domain; Region: TrkA_N; pfam02254 1138383009664 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1138383009665 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138383009666 generic binding surface II; other site 1138383009667 ssDNA binding site; other site 1138383009668 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1138383009669 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138383009670 trimer interface [polypeptide binding]; other site 1138383009671 active site 1138383009672 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1138383009673 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1138383009674 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138383009675 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138383009676 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1138383009677 active site 1138383009678 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138383009679 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383009680 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138383009681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383009682 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138383009683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383009684 DNA binding residues [nucleotide binding] 1138383009685 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1138383009686 homotrimer interaction site [polypeptide binding]; other site 1138383009687 putative active site [active] 1138383009688 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1138383009689 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1138383009690 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1138383009691 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138383009692 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1138383009693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383009694 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138383009695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383009696 DNA binding residues [nucleotide binding] 1138383009697 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138383009698 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1138383009699 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138383009700 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1138383009701 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1138383009702 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1138383009703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383009704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383009705 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383009706 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138383009707 PAC2 family; Region: PAC2; pfam09754 1138383009708 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383009709 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138383009710 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1138383009711 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138383009712 heme-binding site [chemical binding]; other site 1138383009713 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 1138383009714 ATP cone domain; Region: ATP-cone; pfam03477 1138383009715 LexA repressor; Validated; Region: PRK00215 1138383009716 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1138383009717 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1138383009718 Catalytic site [active] 1138383009719 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138383009720 LGFP repeat; Region: LGFP; pfam08310 1138383009721 LGFP repeat; Region: LGFP; pfam08310 1138383009722 LGFP repeat; Region: LGFP; pfam08310 1138383009723 LGFP repeat; Region: LGFP; pfam08310 1138383009724 LGFP repeat; Region: LGFP; pfam08310 1138383009725 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383009726 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383009727 active site 1138383009728 GTPases [General function prediction only]; Region: HflX; COG2262 1138383009729 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1138383009730 HflX GTPase family; Region: HflX; cd01878 1138383009731 G1 box; other site 1138383009732 GTP/Mg2+ binding site [chemical binding]; other site 1138383009733 Switch I region; other site 1138383009734 G2 box; other site 1138383009735 G3 box; other site 1138383009736 Switch II region; other site 1138383009737 G4 box; other site 1138383009738 G5 box; other site 1138383009739 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1138383009740 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138383009741 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138383009742 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1138383009743 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1138383009744 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1138383009745 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138383009746 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138383009747 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138383009748 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1138383009749 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1138383009750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383009751 FeS/SAM binding site; other site 1138383009752 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1138383009753 recombinase A; Provisional; Region: recA; PRK09354 1138383009754 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1138383009755 hexamer interface [polypeptide binding]; other site 1138383009756 Walker A motif; other site 1138383009757 ATP binding site [chemical binding]; other site 1138383009758 Walker B motif; other site 1138383009759 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1138383009760 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1138383009761 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138383009762 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138383009763 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1138383009764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138383009765 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 1138383009766 PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674 1138383009767 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138383009768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383009769 non-specific DNA binding site [nucleotide binding]; other site 1138383009770 salt bridge; other site 1138383009771 sequence-specific DNA binding site [nucleotide binding]; other site 1138383009772 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138383009773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383009774 Coenzyme A binding pocket [chemical binding]; other site 1138383009775 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1138383009776 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1138383009777 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383009778 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1138383009779 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138383009780 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1138383009781 classical (c) SDRs; Region: SDR_c; cd05233 1138383009782 NAD(P) binding site [chemical binding]; other site 1138383009783 active site 1138383009784 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383009785 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383009786 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1138383009787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383009788 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1138383009789 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138383009790 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1138383009791 dimer interface [polypeptide binding]; other site 1138383009792 active site 1138383009793 catalytic residue [active] 1138383009794 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1138383009795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1138383009796 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1138383009797 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1138383009798 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1138383009799 folate binding site [chemical binding]; other site 1138383009800 NADP+ binding site [chemical binding]; other site 1138383009801 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1138383009802 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1138383009803 dimerization interface [polypeptide binding]; other site 1138383009804 active site 1138383009805 Dienelactone hydrolase family; Region: DLH; pfam01738 1138383009806 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383009807 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383009808 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383009809 active site 1138383009810 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383009811 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383009812 active site 1138383009813 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138383009814 classical (c) SDRs; Region: SDR_c; cd05233 1138383009815 NAD(P) binding site [chemical binding]; other site 1138383009816 active site 1138383009817 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1138383009818 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138383009819 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383009820 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138383009821 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1138383009822 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138383009823 carboxyltransferase (CT) interaction site; other site 1138383009824 biotinylation site [posttranslational modification]; other site 1138383009825 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138383009826 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383009827 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383009828 acyl-activating enzyme (AAE) consensus motif; other site 1138383009829 AMP binding site [chemical binding]; other site 1138383009830 active site 1138383009831 CoA binding site [chemical binding]; other site 1138383009832 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138383009833 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383009834 CoenzymeA binding site [chemical binding]; other site 1138383009835 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138383009836 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138383009837 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1138383009838 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138383009839 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1138383009840 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383009841 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138383009842 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383009843 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383009844 [2Fe-2S] cluster binding site [ion binding]; other site 1138383009845 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1138383009846 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138383009847 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1138383009848 FMN-binding pocket [chemical binding]; other site 1138383009849 flavin binding motif; other site 1138383009850 phosphate binding motif [ion binding]; other site 1138383009851 beta-alpha-beta structure motif; other site 1138383009852 NAD binding pocket [chemical binding]; other site 1138383009853 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383009854 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138383009855 catalytic loop [active] 1138383009856 iron binding site [ion binding]; other site 1138383009857 short chain dehydrogenase; Validated; Region: PRK05855 1138383009858 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383009859 classical (c) SDRs; Region: SDR_c; cd05233 1138383009860 NAD(P) binding site [chemical binding]; other site 1138383009861 active site 1138383009862 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138383009863 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138383009864 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383009865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383009866 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383009867 hydrophobic ligand binding site; other site 1138383009868 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1138383009869 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1138383009870 hexamer interface [polypeptide binding]; other site 1138383009871 ligand binding site [chemical binding]; other site 1138383009872 putative active site [active] 1138383009873 NAD(P) binding site [chemical binding]; other site 1138383009874 Nitronate monooxygenase; Region: NMO; pfam03060 1138383009875 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383009876 FMN binding site [chemical binding]; other site 1138383009877 substrate binding site [chemical binding]; other site 1138383009878 putative catalytic residue [active] 1138383009879 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1138383009880 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1138383009881 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1138383009882 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1138383009883 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1138383009884 oligomer interface [polypeptide binding]; other site 1138383009885 RNA binding site [nucleotide binding]; other site 1138383009886 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1138383009887 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1138383009888 RNase E interface [polypeptide binding]; other site 1138383009889 trimer interface [polypeptide binding]; other site 1138383009890 active site 1138383009891 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1138383009892 putative nucleic acid binding region [nucleotide binding]; other site 1138383009893 G-X-X-G motif; other site 1138383009894 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1138383009895 RNA binding site [nucleotide binding]; other site 1138383009896 domain interface; other site 1138383009897 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1138383009898 16S/18S rRNA binding site [nucleotide binding]; other site 1138383009899 S13e-L30e interaction site [polypeptide binding]; other site 1138383009900 25S rRNA binding site [nucleotide binding]; other site 1138383009901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383009902 dimerization interface [polypeptide binding]; other site 1138383009903 putative DNA binding site [nucleotide binding]; other site 1138383009904 putative Zn2+ binding site [ion binding]; other site 1138383009905 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1138383009906 putative hydrophobic ligand binding site [chemical binding]; other site 1138383009907 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1138383009908 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1138383009909 active site 1138383009910 Riboflavin kinase; Region: Flavokinase; pfam01687 1138383009911 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138383009912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383009913 putative DNA binding site [nucleotide binding]; other site 1138383009914 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138383009915 FeoA domain; Region: FeoA; pfam04023 1138383009916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383009917 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383009918 active site 1138383009919 lipid-transfer protein; Provisional; Region: PRK08256 1138383009920 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383009921 active site 1138383009922 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1138383009923 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1138383009924 RNA binding site [nucleotide binding]; other site 1138383009925 active site 1138383009926 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1138383009927 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1138383009928 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1138383009929 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138383009930 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138383009931 active site 1138383009932 metal binding site [ion binding]; metal-binding site 1138383009933 Predicted acyl esterases [General function prediction only]; Region: COG2936 1138383009934 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138383009935 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1138383009936 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1138383009937 enoyl-CoA hydratase; Provisional; Region: PRK06190 1138383009938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383009939 substrate binding site [chemical binding]; other site 1138383009940 oxyanion hole (OAH) forming residues; other site 1138383009941 trimer interface [polypeptide binding]; other site 1138383009942 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1138383009943 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1138383009944 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1138383009945 DHH family; Region: DHH; pfam01368 1138383009946 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1138383009947 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1138383009948 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1138383009949 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1138383009950 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1138383009951 G1 box; other site 1138383009952 putative GEF interaction site [polypeptide binding]; other site 1138383009953 GTP/Mg2+ binding site [chemical binding]; other site 1138383009954 Switch I region; other site 1138383009955 G2 box; other site 1138383009956 G3 box; other site 1138383009957 Switch II region; other site 1138383009958 G4 box; other site 1138383009959 G5 box; other site 1138383009960 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1138383009961 Translation-initiation factor 2; Region: IF-2; pfam11987 1138383009962 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1138383009963 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1138383009964 putative RNA binding cleft [nucleotide binding]; other site 1138383009965 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1138383009966 NusA N-terminal domain; Region: NusA_N; pfam08529 1138383009967 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1138383009968 RNA binding site [nucleotide binding]; other site 1138383009969 homodimer interface [polypeptide binding]; other site 1138383009970 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138383009971 G-X-X-G motif; other site 1138383009972 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138383009973 G-X-X-G motif; other site 1138383009974 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1138383009975 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1138383009976 putative oligomer interface [polypeptide binding]; other site 1138383009977 putative RNA binding site [nucleotide binding]; other site 1138383009978 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1138383009979 dinuclear metal binding motif [ion binding]; other site 1138383009980 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1138383009981 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1138383009982 dimer interface [polypeptide binding]; other site 1138383009983 motif 1; other site 1138383009984 active site 1138383009985 motif 2; other site 1138383009986 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1138383009987 putative deacylase active site [active] 1138383009988 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138383009989 active site 1138383009990 motif 3; other site 1138383009991 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1138383009992 anticodon binding site; other site 1138383009993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383009994 putative substrate translocation pore; other site 1138383009995 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1138383009996 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1138383009997 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1138383009998 active site 1138383009999 SAM binding site [chemical binding]; other site 1138383010000 homodimer interface [polypeptide binding]; other site 1138383010001 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1138383010002 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138383010003 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1138383010004 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1138383010005 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1138383010006 Walker A motif; other site 1138383010007 homodimer interface [polypeptide binding]; other site 1138383010008 ATP binding site [chemical binding]; other site 1138383010009 hydroxycobalamin binding site [chemical binding]; other site 1138383010010 Walker B motif; other site 1138383010011 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1138383010012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383010013 Walker A motif; other site 1138383010014 ATP binding site [chemical binding]; other site 1138383010015 Walker B motif; other site 1138383010016 arginine finger; other site 1138383010017 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1138383010018 metal ion-dependent adhesion site (MIDAS); other site 1138383010019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138383010020 Coenzyme A binding pocket [chemical binding]; other site 1138383010021 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1138383010022 malate:quinone oxidoreductase; Validated; Region: PRK05257 1138383010023 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138383010024 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383010025 mycothione reductase; Reviewed; Region: PRK07846 1138383010026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383010027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383010028 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383010029 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1138383010030 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 1138383010031 nickel binding site [ion binding]; other site 1138383010032 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1138383010033 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1138383010034 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1138383010035 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383010036 PPE family; Region: PPE; pfam00823 1138383010037 short chain dehydrogenase; Provisional; Region: PRK06057 1138383010038 classical (c) SDRs; Region: SDR_c; cd05233 1138383010039 NAD(P) binding site [chemical binding]; other site 1138383010040 active site 1138383010041 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383010042 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383010043 NAD(P) binding site [chemical binding]; other site 1138383010044 catalytic residues [active] 1138383010045 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1138383010046 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1138383010047 catalytic triad [active] 1138383010048 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138383010049 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138383010050 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138383010051 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383010052 cobyric acid synthase; Provisional; Region: PRK00784 1138383010053 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1138383010054 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138383010055 catalytic triad [active] 1138383010056 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138383010057 active site 1138383010058 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138383010059 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1138383010060 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138383010061 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138383010062 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1138383010063 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1138383010064 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138383010065 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1138383010066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138383010067 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1138383010068 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1138383010069 active site 1138383010070 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1138383010071 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1138383010072 putative substrate binding region [chemical binding]; other site 1138383010073 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1138383010074 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1138383010075 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1138383010076 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1138383010077 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138383010078 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1138383010079 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138383010080 catalytic residues [active] 1138383010081 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1138383010082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383010083 FeS/SAM binding site; other site 1138383010084 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1138383010085 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1138383010086 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1138383010087 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1138383010088 hinge region; other site 1138383010089 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1138383010090 putative nucleotide binding site [chemical binding]; other site 1138383010091 uridine monophosphate binding site [chemical binding]; other site 1138383010092 homohexameric interface [polypeptide binding]; other site 1138383010093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383010094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383010095 DNA binding site [nucleotide binding] 1138383010096 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383010097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138383010098 putative acyl-acceptor binding pocket; other site 1138383010099 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1138383010100 short chain dehydrogenase; Provisional; Region: PRK06701 1138383010101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010102 NAD(P) binding site [chemical binding]; other site 1138383010103 active site 1138383010104 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1138383010105 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138383010106 Moco binding site; other site 1138383010107 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138383010108 metal coordination site [ion binding]; other site 1138383010109 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1138383010110 ChaB; Region: ChaB; pfam06150 1138383010111 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1138383010112 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383010113 MarR family; Region: MarR; pfam01047 1138383010114 amidase; Provisional; Region: PRK07869 1138383010115 Amidase; Region: Amidase; pfam01425 1138383010116 elongation factor Ts; Provisional; Region: tsf; PRK09377 1138383010117 UBA/TS-N domain; Region: UBA; pfam00627 1138383010118 Elongation factor TS; Region: EF_TS; pfam00889 1138383010119 Elongation factor TS; Region: EF_TS; pfam00889 1138383010120 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1138383010121 rRNA interaction site [nucleotide binding]; other site 1138383010122 S8 interaction site; other site 1138383010123 putative laminin-1 binding site; other site 1138383010124 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138383010125 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138383010126 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1138383010127 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138383010128 active site 1138383010129 DNA binding site [nucleotide binding] 1138383010130 Int/Topo IB signature motif; other site 1138383010131 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1138383010132 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1138383010133 putative active site [active] 1138383010134 putative substrate binding site [chemical binding]; other site 1138383010135 putative FMN binding site [chemical binding]; other site 1138383010136 putative catalytic residues [active] 1138383010137 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138383010138 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138383010139 FAD binding pocket [chemical binding]; other site 1138383010140 FAD binding motif [chemical binding]; other site 1138383010141 phosphate binding motif [ion binding]; other site 1138383010142 NAD binding pocket [chemical binding]; other site 1138383010143 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1138383010144 DNA protecting protein DprA; Region: dprA; TIGR00732 1138383010145 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1138383010146 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1138383010147 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138383010148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383010149 Walker A motif; other site 1138383010150 ATP binding site [chemical binding]; other site 1138383010151 Walker B motif; other site 1138383010152 arginine finger; other site 1138383010153 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1138383010154 hypothetical protein; Reviewed; Region: PRK12497 1138383010155 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1138383010156 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1138383010157 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1138383010158 putative molybdopterin cofactor binding site [chemical binding]; other site 1138383010159 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1138383010160 putative molybdopterin cofactor binding site; other site 1138383010161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010162 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138383010163 NAD(P) binding site [chemical binding]; other site 1138383010164 active site 1138383010165 ANTAR domain; Region: ANTAR; pfam03861 1138383010166 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1138383010167 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1138383010168 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138383010169 active site 1138383010170 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1138383010171 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138383010172 Catalytic site [active] 1138383010173 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138383010174 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1138383010175 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1138383010176 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1138383010177 RimM N-terminal domain; Region: RimM; pfam01782 1138383010178 PRC-barrel domain; Region: PRC; pfam05239 1138383010179 hypothetical protein; Provisional; Region: PRK02821 1138383010180 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1138383010181 G-X-X-G motif; other site 1138383010182 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1138383010183 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138383010184 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138383010185 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138383010186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383010188 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138383010189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383010190 active site 1138383010191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383010192 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138383010193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383010194 active site 1138383010195 signal recognition particle protein; Provisional; Region: PRK10867 1138383010196 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1138383010197 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1138383010198 P loop; other site 1138383010199 GTP binding site [chemical binding]; other site 1138383010200 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1138383010201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383010202 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138383010203 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138383010204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383010205 ATP binding site [chemical binding]; other site 1138383010206 putative Mg++ binding site [ion binding]; other site 1138383010207 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383010208 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383010209 active site 1138383010210 PII uridylyl-transferase; Provisional; Region: PRK03381 1138383010211 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138383010212 metal binding triad; other site 1138383010213 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138383010214 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1138383010215 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1138383010216 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1138383010217 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1138383010218 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1138383010219 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1138383010220 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1138383010221 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1138383010222 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138383010223 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138383010224 AAA domain; Region: AAA_23; pfam13476 1138383010225 Walker A/P-loop; other site 1138383010226 ATP binding site [chemical binding]; other site 1138383010227 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1138383010228 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1138383010229 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138383010230 ABC transporter signature motif; other site 1138383010231 Walker B; other site 1138383010232 D-loop; other site 1138383010233 H-loop/switch region; other site 1138383010234 acylphosphatase; Provisional; Region: PRK14422 1138383010235 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1138383010236 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1138383010237 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1138383010238 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1138383010239 DNA binding site [nucleotide binding] 1138383010240 catalytic residue [active] 1138383010241 H2TH interface [polypeptide binding]; other site 1138383010242 putative catalytic residues [active] 1138383010243 turnover-facilitating residue; other site 1138383010244 intercalation triad [nucleotide binding]; other site 1138383010245 8OG recognition residue [nucleotide binding]; other site 1138383010246 putative reading head residues; other site 1138383010247 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138383010248 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138383010249 ribonuclease III; Reviewed; Region: rnc; PRK00102 1138383010250 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1138383010251 dimerization interface [polypeptide binding]; other site 1138383010252 active site 1138383010253 metal binding site [ion binding]; metal-binding site 1138383010254 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1138383010255 dsRNA binding site [nucleotide binding]; other site 1138383010256 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1138383010257 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138383010258 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1138383010259 Predicted permease; Region: DUF318; pfam03773 1138383010260 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1138383010261 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138383010262 PYR/PP interface [polypeptide binding]; other site 1138383010263 dimer interface [polypeptide binding]; other site 1138383010264 TPP binding site [chemical binding]; other site 1138383010265 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383010266 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1138383010267 TPP-binding site [chemical binding]; other site 1138383010268 dimer interface [polypeptide binding]; other site 1138383010269 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1138383010270 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1138383010271 (T/H)XGH motif; other site 1138383010272 active site 1138383010273 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1138383010274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383010275 S-adenosylmethionine binding site [chemical binding]; other site 1138383010276 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1138383010277 putative active site [active] 1138383010278 redox center [active] 1138383010279 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1138383010280 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1138383010281 catalytic residues [active] 1138383010282 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383010283 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383010284 substrate binding pocket [chemical binding]; other site 1138383010285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383010286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383010287 active site 1138383010288 catalytic tetrad [active] 1138383010289 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1138383010290 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1138383010291 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138383010292 ssDNA binding site; other site 1138383010293 generic binding surface II; other site 1138383010294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383010295 ATP binding site [chemical binding]; other site 1138383010296 putative Mg++ binding site [ion binding]; other site 1138383010297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383010298 nucleotide binding region [chemical binding]; other site 1138383010299 ATP-binding site [chemical binding]; other site 1138383010300 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1138383010301 DAK2 domain; Region: Dak2; cl03685 1138383010302 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138383010303 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138383010304 catalytic residue [active] 1138383010305 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138383010306 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383010307 classical (c) SDRs; Region: SDR_c; cd05233 1138383010308 NAD(P) binding site [chemical binding]; other site 1138383010309 active site 1138383010310 short chain dehydrogenase; Provisional; Region: PRK06197 1138383010311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010312 NAD(P) binding site [chemical binding]; other site 1138383010313 active site 1138383010314 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138383010315 short chain dehydrogenase; Provisional; Region: PRK06180 1138383010316 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138383010317 NADP binding site [chemical binding]; other site 1138383010318 active site 1138383010319 steroid binding site; other site 1138383010320 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138383010321 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138383010322 putative NAD(P) binding site [chemical binding]; other site 1138383010323 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1138383010324 ligand binding site [chemical binding]; other site 1138383010325 active site 1138383010326 UGI interface [polypeptide binding]; other site 1138383010327 catalytic site [active] 1138383010328 thiamine monophosphate kinase; Provisional; Region: PRK05731 1138383010329 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1138383010330 ATP binding site [chemical binding]; other site 1138383010331 dimerization interface [polypeptide binding]; other site 1138383010332 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1138383010333 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1138383010334 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1138383010335 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1138383010336 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1138383010337 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138383010338 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138383010339 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1138383010340 polyphosphate kinase; Provisional; Region: PRK05443 1138383010341 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1138383010342 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1138383010343 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1138383010344 putative domain interface [polypeptide binding]; other site 1138383010345 putative active site [active] 1138383010346 catalytic site [active] 1138383010347 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1138383010348 putative domain interface [polypeptide binding]; other site 1138383010349 putative active site [active] 1138383010350 catalytic site [active] 1138383010351 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138383010352 active site 1138383010353 Ap6A binding site [chemical binding]; other site 1138383010354 nudix motif; other site 1138383010355 metal binding site [ion binding]; metal-binding site 1138383010356 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383010357 catalytic core [active] 1138383010358 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1138383010359 IHF dimer interface [polypeptide binding]; other site 1138383010360 IHF - DNA interface [nucleotide binding]; other site 1138383010361 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1138383010362 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1138383010363 substrate binding site [chemical binding]; other site 1138383010364 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1138383010365 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1138383010366 substrate binding site [chemical binding]; other site 1138383010367 ligand binding site [chemical binding]; other site 1138383010368 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383010369 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138383010370 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138383010371 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138383010372 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1138383010373 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138383010374 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1138383010375 active site 1138383010376 KMSKS motif; other site 1138383010377 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1138383010378 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138383010379 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138383010380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383010381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138383010382 putative substrate translocation pore; other site 1138383010383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383010384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138383010385 putative substrate translocation pore; other site 1138383010386 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1138383010387 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1138383010388 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1138383010389 ligand binding site [chemical binding]; other site 1138383010390 NAD binding site [chemical binding]; other site 1138383010391 dimerization interface [polypeptide binding]; other site 1138383010392 catalytic site [active] 1138383010393 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1138383010394 putative L-serine binding site [chemical binding]; other site 1138383010395 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138383010396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383010397 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1138383010398 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138383010399 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1138383010400 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1138383010401 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1138383010402 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1138383010403 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1138383010404 putative valine binding site [chemical binding]; other site 1138383010405 dimer interface [polypeptide binding]; other site 1138383010406 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1138383010407 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1138383010408 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138383010409 PYR/PP interface [polypeptide binding]; other site 1138383010410 dimer interface [polypeptide binding]; other site 1138383010411 TPP binding site [chemical binding]; other site 1138383010412 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383010413 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1138383010414 TPP-binding site [chemical binding]; other site 1138383010415 dimer interface [polypeptide binding]; other site 1138383010416 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138383010417 Predicted membrane protein [Function unknown]; Region: COG2259 1138383010418 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1138383010419 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1138383010420 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1138383010421 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1138383010422 GatB domain; Region: GatB_Yqey; smart00845 1138383010423 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138383010424 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138383010425 P-loop; other site 1138383010426 Magnesium ion binding site [ion binding]; other site 1138383010427 6-phosphofructokinase; Provisional; Region: PRK03202 1138383010428 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1138383010429 active site 1138383010430 ADP/pyrophosphate binding site [chemical binding]; other site 1138383010431 dimerization interface [polypeptide binding]; other site 1138383010432 allosteric effector site; other site 1138383010433 fructose-1,6-bisphosphate binding site; other site 1138383010434 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138383010435 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1138383010436 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1138383010437 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1138383010438 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383010439 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383010440 active site 1138383010441 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138383010442 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383010443 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138383010444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383010446 cystathionine gamma-lyase; Validated; Region: PRK07582 1138383010447 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138383010448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383010449 catalytic residue [active] 1138383010450 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1138383010451 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1138383010452 nucleotide binding pocket [chemical binding]; other site 1138383010453 K-X-D-G motif; other site 1138383010454 catalytic site [active] 1138383010455 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1138383010456 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1138383010457 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1138383010458 Dimer interface [polypeptide binding]; other site 1138383010459 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138383010460 putative DNA binding site [nucleotide binding]; other site 1138383010461 putative Zn2+ binding site [ion binding]; other site 1138383010462 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1138383010463 putative hydrophobic ligand binding site [chemical binding]; other site 1138383010464 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1138383010465 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383010466 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1138383010467 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1138383010468 Ligand Binding Site [chemical binding]; other site 1138383010469 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1138383010470 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1138383010471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138383010472 catalytic residue [active] 1138383010473 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383010474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138383010475 putative acyl-acceptor binding pocket; other site 1138383010476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1138383010477 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1138383010478 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1138383010479 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1138383010480 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1138383010481 Ligand binding site [chemical binding]; other site 1138383010482 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1138383010483 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383010484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383010485 S-adenosylmethionine binding site [chemical binding]; other site 1138383010486 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1138383010487 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1138383010488 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1138383010489 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383010490 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383010491 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1138383010492 putative hydrophobic ligand binding site [chemical binding]; other site 1138383010493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010494 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1138383010495 NAD(P) binding site [chemical binding]; other site 1138383010496 active site 1138383010497 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383010498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010499 NAD(P) binding site [chemical binding]; other site 1138383010500 active site 1138383010501 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383010502 anti sigma factor interaction site; other site 1138383010503 regulatory phosphorylation site [posttranslational modification]; other site 1138383010504 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138383010505 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138383010506 substrate binding pocket [chemical binding]; other site 1138383010507 chain length determination region; other site 1138383010508 substrate-Mg2+ binding site; other site 1138383010509 catalytic residues [active] 1138383010510 aspartate-rich region 1; other site 1138383010511 active site lid residues [active] 1138383010512 aspartate-rich region 2; other site 1138383010513 phytoene desaturase; Region: crtI_fam; TIGR02734 1138383010514 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1138383010515 active site lid residues [active] 1138383010516 substrate binding pocket [chemical binding]; other site 1138383010517 catalytic residues [active] 1138383010518 substrate-Mg2+ binding site; other site 1138383010519 aspartate-rich region 1; other site 1138383010520 aspartate-rich region 2; other site 1138383010521 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1138383010522 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1138383010523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383010524 S-adenosylmethionine binding site [chemical binding]; other site 1138383010525 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1138383010526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383010527 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138383010528 [2Fe-2S] cluster binding site [ion binding]; other site 1138383010529 iron-sulfur cluster [ion binding]; other site 1138383010530 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1138383010531 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1138383010532 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1138383010533 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1138383010534 MarR family; Region: MarR_2; pfam12802 1138383010535 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138383010536 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1138383010537 active site 1138383010538 TDP-binding site; other site 1138383010539 acceptor substrate-binding pocket; other site 1138383010540 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1138383010541 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1138383010542 homotetramer interface [polypeptide binding]; other site 1138383010543 FMN binding site [chemical binding]; other site 1138383010544 homodimer contacts [polypeptide binding]; other site 1138383010545 putative active site [active] 1138383010546 putative substrate binding site [chemical binding]; other site 1138383010547 MMPL family; Region: MMPL; pfam03176 1138383010548 TspO/MBR family; Region: TspO_MBR; pfam03073 1138383010549 DNA photolyase; Region: DNA_photolyase; pfam00875 1138383010550 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1138383010551 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138383010552 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138383010553 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1138383010554 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1138383010555 trimer interface [polypeptide binding]; other site 1138383010556 active site 1138383010557 substrate binding site [chemical binding]; other site 1138383010558 CoA binding site [chemical binding]; other site 1138383010559 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1138383010560 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138383010561 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1138383010562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383010563 S-adenosylmethionine binding site [chemical binding]; other site 1138383010564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383010565 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383010566 substrate binding site [chemical binding]; other site 1138383010567 oxyanion hole (OAH) forming residues; other site 1138383010568 trimer interface [polypeptide binding]; other site 1138383010569 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1138383010570 nudix motif; other site 1138383010571 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1138383010572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383010573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383010574 Walker A/P-loop; other site 1138383010575 Walker A/P-loop; other site 1138383010576 ATP binding site [chemical binding]; other site 1138383010577 ATP binding site [chemical binding]; other site 1138383010578 Q-loop/lid; other site 1138383010579 ABC transporter signature motif; other site 1138383010580 Walker B; other site 1138383010581 D-loop; other site 1138383010582 H-loop/switch region; other site 1138383010583 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1138383010584 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1138383010585 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1138383010586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383010587 motif II; other site 1138383010588 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1138383010589 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1138383010590 D-pathway; other site 1138383010591 Putative ubiquinol binding site [chemical binding]; other site 1138383010592 Low-spin heme (heme b) binding site [chemical binding]; other site 1138383010593 Putative water exit pathway; other site 1138383010594 Binuclear center (heme o3/CuB) [ion binding]; other site 1138383010595 K-pathway; other site 1138383010596 Putative proton exit pathway; other site 1138383010597 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1138383010598 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1138383010599 siderophore binding site; other site 1138383010600 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1138383010601 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1138383010602 putative NAD(P) binding site [chemical binding]; other site 1138383010603 putative substrate binding site [chemical binding]; other site 1138383010604 catalytic Zn binding site [ion binding]; other site 1138383010605 structural Zn binding site [ion binding]; other site 1138383010606 dimer interface [polypeptide binding]; other site 1138383010607 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138383010608 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138383010609 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138383010610 dimer interface [polypeptide binding]; other site 1138383010611 putative radical transfer pathway; other site 1138383010612 diiron center [ion binding]; other site 1138383010613 tyrosyl radical; other site 1138383010614 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1138383010615 putative hydrophobic ligand binding site [chemical binding]; other site 1138383010616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383010618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138383010619 Ligand Binding Site [chemical binding]; other site 1138383010620 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383010621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383010622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383010624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138383010625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1138383010626 putative dimer interface [polypeptide binding]; other site 1138383010627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383010628 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1138383010629 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1138383010630 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1138383010631 active site 1138383010632 dimer interface [polypeptide binding]; other site 1138383010633 catalytic residues [active] 1138383010634 effector binding site; other site 1138383010635 R2 peptide binding site; other site 1138383010636 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1138383010637 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138383010638 catalytic residues [active] 1138383010639 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138383010640 Predicted flavoprotein [General function prediction only]; Region: COG0431 1138383010641 short chain dehydrogenase; Provisional; Region: PRK07832 1138383010642 classical (c) SDRs; Region: SDR_c; cd05233 1138383010643 NAD(P) binding site [chemical binding]; other site 1138383010644 active site 1138383010645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383010647 Cytochrome P450; Region: p450; cl12078 1138383010648 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383010649 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1138383010650 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1138383010651 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138383010652 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138383010653 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138383010654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383010655 DNA-binding site [nucleotide binding]; DNA binding site 1138383010656 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138383010657 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138383010658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1138383010659 DNA-binding site [nucleotide binding]; DNA binding site 1138383010660 FCD domain; Region: FCD; pfam07729 1138383010661 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383010662 active site 1138383010663 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383010664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383010665 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383010666 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383010667 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383010668 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383010669 active site 1138383010670 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1138383010671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010672 NAD(P) binding site [chemical binding]; other site 1138383010673 active site 1138383010674 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1138383010675 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1138383010676 active site 1138383010677 DNA binding site [nucleotide binding] 1138383010678 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1138383010679 DNA binding site [nucleotide binding] 1138383010680 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1138383010681 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1138383010682 nucleotide binding site [chemical binding]; other site 1138383010683 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1138383010684 SBD interface [polypeptide binding]; other site 1138383010685 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138383010686 FMN binding site [chemical binding]; other site 1138383010687 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138383010688 dimer interface [polypeptide binding]; other site 1138383010689 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383010690 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138383010691 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383010692 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1138383010693 dimer interface [polypeptide binding]; other site 1138383010694 active site 1138383010695 enoyl-CoA hydratase; Provisional; Region: PRK05864 1138383010696 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383010697 substrate binding site [chemical binding]; other site 1138383010698 oxyanion hole (OAH) forming residues; other site 1138383010699 trimer interface [polypeptide binding]; other site 1138383010700 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383010701 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383010702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383010703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383010704 active site 1138383010705 MspA; Region: MspA; pfam09203 1138383010706 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383010707 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383010708 putative active site [active] 1138383010709 putative substrate binding site [chemical binding]; other site 1138383010710 ATP binding site [chemical binding]; other site 1138383010711 short chain dehydrogenase; Provisional; Region: PRK08278 1138383010712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010713 NAD(P) binding site [chemical binding]; other site 1138383010714 active site 1138383010715 Predicted membrane protein [Function unknown]; Region: COG2259 1138383010716 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383010717 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1138383010718 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383010719 Transport protein; Region: actII; TIGR00833 1138383010720 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383010721 classical (c) SDRs; Region: SDR_c; cd05233 1138383010722 NAD(P) binding site [chemical binding]; other site 1138383010723 active site 1138383010724 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383010725 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138383010726 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138383010727 substrate binding pocket [chemical binding]; other site 1138383010728 active site 1138383010729 iron coordination sites [ion binding]; other site 1138383010730 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383010731 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383010732 [2Fe-2S] cluster binding site [ion binding]; other site 1138383010733 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138383010734 alpha subunit interface [polypeptide binding]; other site 1138383010735 active site 1138383010736 substrate binding site [chemical binding]; other site 1138383010737 Fe binding site [ion binding]; other site 1138383010738 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383010739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383010740 NAD(P) binding site [chemical binding]; other site 1138383010741 active site 1138383010742 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138383010743 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138383010744 FAD binding pocket [chemical binding]; other site 1138383010745 FAD binding motif [chemical binding]; other site 1138383010746 phosphate binding motif [ion binding]; other site 1138383010747 beta-alpha-beta structure motif; other site 1138383010748 NAD(p) ribose binding residues [chemical binding]; other site 1138383010749 NAD binding pocket [chemical binding]; other site 1138383010750 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138383010751 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383010752 catalytic loop [active] 1138383010753 iron binding site [ion binding]; other site 1138383010754 MarR family; Region: MarR_2; pfam12802 1138383010755 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383010756 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138383010757 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138383010758 active site 1138383010759 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383010760 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383010761 [2Fe-2S] cluster binding site [ion binding]; other site 1138383010762 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138383010763 alpha subunit interface [polypeptide binding]; other site 1138383010764 active site 1138383010765 substrate binding site [chemical binding]; other site 1138383010766 Fe binding site [ion binding]; other site 1138383010767 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383010768 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138383010769 NAD binding site [chemical binding]; other site 1138383010770 catalytic residues [active] 1138383010771 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1138383010772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383010773 acyl-activating enzyme (AAE) consensus motif; other site 1138383010774 AMP binding site [chemical binding]; other site 1138383010775 active site 1138383010776 CoA binding site [chemical binding]; other site 1138383010777 Fic/DOC family; Region: Fic; cl00960 1138383010778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383010779 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1138383010780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383010781 phosphoglucomutase; Validated; Region: PRK07564 1138383010782 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1138383010783 active site 1138383010784 substrate binding site [chemical binding]; other site 1138383010785 metal binding site [ion binding]; metal-binding site 1138383010786 camphor resistance protein CrcB; Provisional; Region: PRK14216 1138383010787 camphor resistance protein CrcB; Provisional; Region: PRK14228 1138383010788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138383010789 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138383010790 Protein of unknown function, DUF488; Region: DUF488; cl01246 1138383010791 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383010792 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383010793 active site 1138383010794 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138383010795 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383010796 Fe binding site [ion binding]; other site 1138383010797 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1138383010798 hypothetical protein; Validated; Region: PRK00029 1138383010799 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383010800 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383010801 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1138383010802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010803 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138383010804 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383010805 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1138383010806 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1138383010807 putative active site [active] 1138383010808 catalytic site [active] 1138383010809 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1138383010810 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1138383010811 putative active site [active] 1138383010812 putative active site [active] 1138383010813 catalytic site [active] 1138383010814 catalytic site [active] 1138383010815 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1138383010816 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1138383010817 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383010818 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1138383010819 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383010820 cyclase homology domain; Region: CHD; cd07302 1138383010821 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138383010822 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383010823 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138383010824 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138383010825 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383010826 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383010827 [2Fe-2S] cluster binding site [ion binding]; other site 1138383010828 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138383010829 alpha subunit interface [polypeptide binding]; other site 1138383010830 active site 1138383010831 substrate binding site [chemical binding]; other site 1138383010832 Fe binding site [ion binding]; other site 1138383010833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383010834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383010835 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1138383010836 putative effector binding pocket; other site 1138383010837 dimerization interface [polypeptide binding]; other site 1138383010838 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383010839 phosphopeptide binding site; other site 1138383010840 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383010841 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383010842 phosphopeptide binding site; other site 1138383010843 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1138383010844 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138383010845 Walker A/P-loop; other site 1138383010846 ATP binding site [chemical binding]; other site 1138383010847 Q-loop/lid; other site 1138383010848 ABC transporter signature motif; other site 1138383010849 Walker B; other site 1138383010850 D-loop; other site 1138383010851 H-loop/switch region; other site 1138383010852 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138383010853 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383010854 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383010855 active site 1138383010856 ATP binding site [chemical binding]; other site 1138383010857 substrate binding site [chemical binding]; other site 1138383010858 activation loop (A-loop); other site 1138383010859 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138383010860 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1138383010861 Kelch domain; Region: Kelch; smart00612 1138383010862 Kelch motif; Region: Kelch_1; pfam01344 1138383010863 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138383010864 Kelch motif; Region: Kelch_1; pfam01344 1138383010865 Kelch domain; Region: Kelch; smart00612 1138383010866 Kelch motif; Region: Kelch_6; pfam13964 1138383010867 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138383010868 Kelch motif; Region: Kelch_1; pfam01344 1138383010869 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383010870 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138383010871 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1138383010872 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383010873 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383010874 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383010875 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383010876 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138383010877 Enoylreductase; Region: PKS_ER; smart00829 1138383010878 putative NAD(P) binding site [chemical binding]; other site 1138383010879 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383010880 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383010881 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383010882 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138383010883 molybdopterin cofactor binding site; other site 1138383010884 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138383010885 putative molybdopterin cofactor binding site; other site 1138383010886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383010888 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383010889 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383010890 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1138383010891 SmpB-tmRNA interface; other site 1138383010892 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1138383010893 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1138383010894 FtsX-like permease family; Region: FtsX; pfam02687 1138383010895 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1138383010896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138383010897 Walker A/P-loop; other site 1138383010898 ATP binding site [chemical binding]; other site 1138383010899 Q-loop/lid; other site 1138383010900 ABC transporter signature motif; other site 1138383010901 Walker B; other site 1138383010902 D-loop; other site 1138383010903 H-loop/switch region; other site 1138383010904 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138383010905 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138383010906 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1138383010907 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138383010908 RF-1 domain; Region: RF-1; pfam00472 1138383010909 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1138383010910 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138383010911 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1138383010912 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1138383010913 Binuclear center (active site) [active] 1138383010914 K-pathway; other site 1138383010915 Putative proton exit pathway; other site 1138383010916 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138383010917 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138383010918 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138383010919 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383010920 PPE family; Region: PPE; pfam00823 1138383010921 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383010922 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383010923 PPE family; Region: PPE; pfam00823 1138383010924 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383010925 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1138383010926 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138383010927 active site 1138383010928 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383010929 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383010930 active site 1138383010931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383010932 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383010933 active site 1138383010934 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383010935 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383010936 active site 1138383010937 catalytic tetrad [active] 1138383010938 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1138383010939 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1138383010940 NADP binding site [chemical binding]; other site 1138383010941 dimer interface [polypeptide binding]; other site 1138383010942 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138383010943 Enoylreductase; Region: PKS_ER; smart00829 1138383010944 NAD(P) binding site [chemical binding]; other site 1138383010945 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1138383010946 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383010947 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138383010948 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383010949 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383010950 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1138383010951 active site 1138383010952 catalytic residues [active] 1138383010953 metal binding site [ion binding]; metal-binding site 1138383010954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383010955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383010956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383010957 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383010958 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383010959 active site 1138383010960 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383010961 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383010962 putative active site [active] 1138383010963 putative substrate binding site [chemical binding]; other site 1138383010964 ATP binding site [chemical binding]; other site 1138383010965 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1138383010966 YceI-like domain; Region: YceI; pfam04264 1138383010967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1138383010968 active site 1138383010969 phosphorylation site [posttranslational modification] 1138383010970 intermolecular recognition site; other site 1138383010971 dimerization interface [polypeptide binding]; other site 1138383010972 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1138383010973 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1138383010974 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1138383010975 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1138383010976 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1138383010977 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1138383010978 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1138383010979 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1138383010980 putative dimer interface [polypeptide binding]; other site 1138383010981 [2Fe-2S] cluster binding site [ion binding]; other site 1138383010982 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1138383010983 SLBB domain; Region: SLBB; pfam10531 1138383010984 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1138383010985 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1138383010986 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383010987 catalytic loop [active] 1138383010988 iron binding site [ion binding]; other site 1138383010989 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1138383010990 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383010991 molybdopterin cofactor binding site; other site 1138383010992 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1138383010993 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1138383010994 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1138383010995 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1138383010996 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383010997 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383010998 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1138383010999 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1138383011000 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1138383011001 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1138383011002 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138383011003 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1138383011004 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138383011005 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1138383011006 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138383011007 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138383011008 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138383011009 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138383011010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383011011 Walker A motif; other site 1138383011012 ATP binding site [chemical binding]; other site 1138383011013 Walker B motif; other site 1138383011014 arginine finger; other site 1138383011015 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138383011016 classical (c) SDRs; Region: SDR_c; cd05233 1138383011017 NAD(P) binding site [chemical binding]; other site 1138383011018 active site 1138383011019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383011020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383011021 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383011022 putative active site [active] 1138383011023 putative substrate binding site [chemical binding]; other site 1138383011024 ATP binding site [chemical binding]; other site 1138383011025 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383011026 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1138383011027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383011028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383011029 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383011030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383011031 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138383011032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383011033 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138383011034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383011035 potential frameshift: common BLAST hit: gi|118462298|ref|YP_883218.1| CheR methyltransferase SAM binding domain-containing protein 1138383011036 PAS domain; Region: PAS; smart00091 1138383011037 PAS domain; Region: PAS_9; pfam13426 1138383011038 putative active site [active] 1138383011039 heme pocket [chemical binding]; other site 1138383011040 potential frameshift: common BLAST hit: gi|118462298|ref|YP_883218.1| CheR methyltransferase SAM binding domain-containing protein 1138383011041 PAS fold; Region: PAS; pfam00989 1138383011042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138383011043 putative active site [active] 1138383011044 heme pocket [chemical binding]; other site 1138383011045 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1138383011046 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1138383011047 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1138383011048 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1138383011049 CheB methylesterase; Region: CheB_methylest; pfam01339 1138383011050 hydroperoxidase II; Provisional; Region: katE; PRK11249 1138383011051 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1138383011052 tetramer interface [polypeptide binding]; other site 1138383011053 heme binding pocket [chemical binding]; other site 1138383011054 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1138383011055 domain interactions; other site 1138383011056 transcription termination factor Rho; Provisional; Region: PRK12678 1138383011057 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383011058 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1138383011059 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1138383011060 putative catalytic site [active] 1138383011061 putative metal binding site [ion binding]; other site 1138383011062 putative phosphate binding site [ion binding]; other site 1138383011063 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138383011064 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138383011065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383011066 NAD(P) binding site [chemical binding]; other site 1138383011067 active site 1138383011068 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 1138383011069 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138383011070 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 1138383011071 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1138383011072 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1138383011073 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1138383011074 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1138383011075 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1138383011076 active site 1138383011077 DNA binding site [nucleotide binding] 1138383011078 Int/Topo IB signature motif; other site 1138383011079 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1138383011080 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1138383011081 PYR/PP interface [polypeptide binding]; other site 1138383011082 dimer interface [polypeptide binding]; other site 1138383011083 tetramer interface [polypeptide binding]; other site 1138383011084 TPP binding site [chemical binding]; other site 1138383011085 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383011086 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1138383011087 TPP-binding site [chemical binding]; other site 1138383011088 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1138383011089 Fe-S cluster binding site [ion binding]; other site 1138383011090 active site 1138383011091 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383011092 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138383011093 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138383011094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383011095 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383011096 active site 1138383011097 catalytic tetrad [active] 1138383011098 classical (c) SDRs; Region: SDR_c; cd05233 1138383011099 NAD(P) binding site [chemical binding]; other site 1138383011100 active site 1138383011101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138383011102 PAS fold; Region: PAS_3; pfam08447 1138383011103 putative active site [active] 1138383011104 heme pocket [chemical binding]; other site 1138383011105 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138383011106 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138383011107 metal binding site [ion binding]; metal-binding site 1138383011108 active site 1138383011109 I-site; other site 1138383011110 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1138383011111 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1138383011112 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1138383011113 active site 1138383011114 catalytic site [active] 1138383011115 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1138383011116 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383011117 NAD binding site [chemical binding]; other site 1138383011118 catalytic Zn binding site [ion binding]; other site 1138383011119 structural Zn binding site [ion binding]; other site 1138383011120 potential frameshift: common BLAST hit: gi|118466121|ref|YP_883251.1| ANTAR domain-containing protein 1138383011121 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383011122 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138383011123 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1138383011124 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1138383011125 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383011126 DNA binding residues [nucleotide binding] 1138383011127 putative dimer interface [polypeptide binding]; other site 1138383011128 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138383011129 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138383011130 putative dimer interface [polypeptide binding]; other site 1138383011131 PAS fold; Region: PAS_3; pfam08447 1138383011132 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383011133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138383011134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383011135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383011136 active site 1138383011137 phosphorylation site [posttranslational modification] 1138383011138 intermolecular recognition site; other site 1138383011139 dimerization interface [polypeptide binding]; other site 1138383011140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383011141 DNA binding residues [nucleotide binding] 1138383011142 dimerization interface [polypeptide binding]; other site 1138383011143 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138383011144 yiaA/B two helix domain; Region: YiaAB; cl01759 1138383011145 Transposase; Region: HTH_Tnp_1; cl17663 1138383011146 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383011147 putative transposase OrfB; Reviewed; Region: PHA02517 1138383011148 HTH-like domain; Region: HTH_21; pfam13276 1138383011149 Integrase core domain; Region: rve; pfam00665 1138383011150 Integrase core domain; Region: rve_3; pfam13683 1138383011151 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138383011152 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1138383011153 FMN-binding pocket [chemical binding]; other site 1138383011154 flavin binding motif; other site 1138383011155 phosphate binding motif [ion binding]; other site 1138383011156 beta-alpha-beta structure motif; other site 1138383011157 NAD binding pocket [chemical binding]; other site 1138383011158 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383011159 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138383011160 catalytic loop [active] 1138383011161 iron binding site [ion binding]; other site 1138383011162 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383011163 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138383011164 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138383011165 acyl-CoA synthetase; Validated; Region: PRK05850 1138383011166 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138383011167 acyl-activating enzyme (AAE) consensus motif; other site 1138383011168 active site 1138383011169 thioester reductase domain; Region: Thioester-redct; TIGR01746 1138383011170 Male sterility protein; Region: NAD_binding_4; pfam07993 1138383011171 NAD(P) binding site [chemical binding]; other site 1138383011172 active site 1138383011173 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138383011174 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138383011175 short chain dehydrogenase; Provisional; Region: PRK06197 1138383011176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383011177 NAD(P) binding site [chemical binding]; other site 1138383011178 active site 1138383011179 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383011180 mce related protein; Region: MCE; pfam02470 1138383011181 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383011182 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1138383011183 catalytic residues [active] 1138383011184 dimer interface [polypeptide binding]; other site 1138383011185 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138383011186 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1138383011187 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383011188 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383011189 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1138383011190 putative transposase OrfB; Reviewed; Region: PHA02517 1138383011191 HTH-like domain; Region: HTH_21; pfam13276 1138383011192 Integrase core domain; Region: rve; pfam00665 1138383011193 Integrase core domain; Region: rve_3; pfam13683 1138383011194 Transposase; Region: HTH_Tnp_1; cl17663 1138383011195 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383011196 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1138383011197 Flavoprotein; Region: Flavoprotein; pfam02441 1138383011198 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1138383011199 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1138383011200 dimerization interface [polypeptide binding]; other site 1138383011201 DPS ferroxidase diiron center [ion binding]; other site 1138383011202 ion pore; other site 1138383011203 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138383011204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383011205 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138383011206 Nitroreductase family; Region: Nitroreductase; pfam00881 1138383011207 FMN binding site [chemical binding]; other site 1138383011208 dimer interface [polypeptide binding]; other site 1138383011209 choline dehydrogenase; Validated; Region: PRK02106 1138383011210 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138383011211 AAA ATPase domain; Region: AAA_16; pfam13191 1138383011212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383011213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383011214 DNA binding residues [nucleotide binding] 1138383011215 dimerization interface [polypeptide binding]; other site 1138383011216 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138383011217 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138383011218 conserved cys residue [active] 1138383011219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383011220 short chain dehydrogenase; Provisional; Region: PRK08219 1138383011221 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138383011222 NADP binding site [chemical binding]; other site 1138383011223 active site 1138383011224 steroid binding site; other site 1138383011225 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138383011226 FMN binding site [chemical binding]; other site 1138383011227 dimer interface [polypeptide binding]; other site 1138383011228 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1138383011229 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138383011230 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138383011231 conserved cys residue [active] 1138383011232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138383011233 hypothetical protein; Validated; Region: PRK00068 1138383011234 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1138383011235 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1138383011236 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138383011237 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1138383011238 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1138383011239 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138383011240 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138383011241 ABC1 family; Region: ABC1; pfam03109 1138383011242 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138383011243 active site 1138383011244 ATP binding site [chemical binding]; other site 1138383011245 Transcription factor WhiB; Region: Whib; pfam02467 1138383011246 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138383011247 Part of AAA domain; Region: AAA_19; pfam13245 1138383011248 Family description; Region: UvrD_C_2; pfam13538 1138383011249 HRDC domain; Region: HRDC; pfam00570 1138383011250 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138383011251 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1138383011252 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1138383011253 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1138383011254 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1138383011255 putative NADH binding site [chemical binding]; other site 1138383011256 putative active site [active] 1138383011257 nudix motif; other site 1138383011258 putative metal binding site [ion binding]; other site 1138383011259 Ion channel; Region: Ion_trans_2; pfam07885 1138383011260 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1138383011261 TrkA-N domain; Region: TrkA_N; pfam02254 1138383011262 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138383011263 Part of AAA domain; Region: AAA_19; pfam13245 1138383011264 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1138383011265 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1138383011266 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138383011267 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1138383011268 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383011269 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383011270 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138383011271 catalytic site [active] 1138383011272 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138383011273 active site 1138383011274 DNA binding site [nucleotide binding] 1138383011275 TIGR02569 family protein; Region: TIGR02569_actnb 1138383011276 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1138383011277 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1138383011278 ATP binding site [chemical binding]; other site 1138383011279 substrate interface [chemical binding]; other site 1138383011280 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1138383011281 active site residue [active] 1138383011282 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1138383011283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383011284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383011285 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1138383011286 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1138383011287 dinuclear metal binding motif [ion binding]; other site 1138383011288 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1138383011289 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138383011290 ATP binding site [chemical binding]; other site 1138383011291 Mg++ binding site [ion binding]; other site 1138383011292 motif III; other site 1138383011293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383011294 nucleotide binding region [chemical binding]; other site 1138383011295 ATP-binding site [chemical binding]; other site 1138383011296 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138383011297 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138383011298 P-loop; other site 1138383011299 Magnesium ion binding site [ion binding]; other site 1138383011300 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138383011301 Magnesium ion binding site [ion binding]; other site 1138383011302 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383011303 catalytic core [active] 1138383011304 isochorismate synthase DhbC; Validated; Region: PRK06923 1138383011305 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138383011306 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138383011307 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138383011308 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138383011309 Transcription factor WhiB; Region: Whib; pfam02467 1138383011310 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1138383011311 PAS domain S-box; Region: sensory_box; TIGR00229 1138383011312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1138383011313 Histidine kinase; Region: HisKA_2; pfam07568 1138383011314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383011315 ATP binding site [chemical binding]; other site 1138383011316 Mg2+ binding site [ion binding]; other site 1138383011317 G-X-G motif; other site 1138383011318 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138383011319 carboxyltransferase (CT) interaction site; other site 1138383011320 biotinylation site [posttranslational modification]; other site 1138383011321 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1138383011322 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1138383011323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383011324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383011325 DNA binding residues [nucleotide binding] 1138383011326 short chain dehydrogenase; Provisional; Region: PRK08278 1138383011327 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1138383011328 NAD(P) binding site [chemical binding]; other site 1138383011329 homodimer interface [polypeptide binding]; other site 1138383011330 active site 1138383011331 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1138383011332 putative deacylase active site [active] 1138383011333 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383011334 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138383011335 NAD(P) binding site [chemical binding]; other site 1138383011336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383011337 active site 1138383011338 metal binding site [ion binding]; metal-binding site 1138383011339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1138383011340 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138383011341 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138383011342 short chain dehydrogenase; Provisional; Region: PRK07856 1138383011343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383011344 NAD(P) binding site [chemical binding]; other site 1138383011345 active site 1138383011346 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383011347 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383011348 classical (c) SDRs; Region: SDR_c; cd05233 1138383011349 NAD(P) binding site [chemical binding]; other site 1138383011350 active site 1138383011351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383011352 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1138383011353 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1138383011354 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1138383011355 hinge; other site 1138383011356 active site 1138383011357 Predicted GTPases [General function prediction only]; Region: COG1162 1138383011358 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1138383011359 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1138383011360 GTP/Mg2+ binding site [chemical binding]; other site 1138383011361 G4 box; other site 1138383011362 G5 box; other site 1138383011363 G1 box; other site 1138383011364 Switch I region; other site 1138383011365 G2 box; other site 1138383011366 G3 box; other site 1138383011367 Switch II region; other site 1138383011368 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138383011369 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138383011370 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138383011371 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383011372 dimer interface [polypeptide binding]; other site 1138383011373 active site 1138383011374 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1138383011375 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1138383011376 putative active site [active] 1138383011377 catalytic triad [active] 1138383011378 putative dimer interface [polypeptide binding]; other site 1138383011379 Domain of unknown function DUF302; Region: DUF302; pfam03625 1138383011380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383011381 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138383011382 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138383011383 putative di-iron ligands [ion binding]; other site 1138383011384 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138383011385 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138383011386 FAD binding pocket [chemical binding]; other site 1138383011387 FAD binding motif [chemical binding]; other site 1138383011388 phosphate binding motif [ion binding]; other site 1138383011389 beta-alpha-beta structure motif; other site 1138383011390 NAD binding pocket [chemical binding]; other site 1138383011391 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383011392 catalytic loop [active] 1138383011393 iron binding site [ion binding]; other site 1138383011394 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383011395 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383011396 NnrU protein; Region: NnrU; cl17713 1138383011397 Phospholipid methyltransferase; Region: PEMT; cl17370 1138383011398 HD domain; Region: HD_5; pfam13487 1138383011399 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138383011400 Zn2+ binding site [ion binding]; other site 1138383011401 Mg2+ binding site [ion binding]; other site 1138383011402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383011403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383011404 DNA binding residues [nucleotide binding] 1138383011405 dimerization interface [polypeptide binding]; other site 1138383011406 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1138383011407 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1138383011408 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1138383011409 30S subunit binding site; other site 1138383011410 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1138383011411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383011412 active site 1138383011413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383011414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383011415 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1138383011416 putative dimerization interface [polypeptide binding]; other site 1138383011417 O-methyltransferase; Region: Methyltransf_2; pfam00891 1138383011418 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383011419 Fe binding site [ion binding]; other site 1138383011420 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383011421 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383011422 substrate binding site [chemical binding]; other site 1138383011423 oxyanion hole (OAH) forming residues; other site 1138383011424 trimer interface [polypeptide binding]; other site 1138383011425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383011426 NAD(P) binding site [chemical binding]; other site 1138383011427 active site 1138383011428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383011429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383011430 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383011431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383011432 acyl-activating enzyme (AAE) consensus motif; other site 1138383011433 AMP binding site [chemical binding]; other site 1138383011434 active site 1138383011435 CoA binding site [chemical binding]; other site 1138383011436 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383011437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383011438 S-adenosylmethionine binding site [chemical binding]; other site 1138383011439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1138383011440 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1138383011441 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1138383011442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383011443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383011444 DNA binding residues [nucleotide binding] 1138383011445 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383011446 Transposase; Region: HTH_Tnp_1; cl17663 1138383011447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138383011448 putative transposase OrfB; Reviewed; Region: PHA02517 1138383011449 HTH-like domain; Region: HTH_21; pfam13276 1138383011450 Integrase core domain; Region: rve; pfam00665 1138383011451 Integrase core domain; Region: rve_3; cl15866 1138383011452 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138383011453 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138383011454 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383011455 Berberine and berberine like; Region: BBE; pfam08031 1138383011456 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1138383011457 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138383011458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383011459 lipoprotein LpqB; Provisional; Region: PRK13616 1138383011460 Sporulation and spore germination; Region: Germane; pfam10646 1138383011461 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1138383011462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138383011463 dimerization interface [polypeptide binding]; other site 1138383011464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383011465 dimer interface [polypeptide binding]; other site 1138383011466 phosphorylation site [posttranslational modification] 1138383011467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383011468 ATP binding site [chemical binding]; other site 1138383011469 Mg2+ binding site [ion binding]; other site 1138383011470 G-X-G motif; other site 1138383011471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383011472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383011473 active site 1138383011474 phosphorylation site [posttranslational modification] 1138383011475 intermolecular recognition site; other site 1138383011476 dimerization interface [polypeptide binding]; other site 1138383011477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383011478 DNA binding site [nucleotide binding] 1138383011479 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1138383011480 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1138383011481 TMP-binding site; other site 1138383011482 ATP-binding site [chemical binding]; other site 1138383011483 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1138383011484 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1138383011485 homotetramer interface [polypeptide binding]; other site 1138383011486 ligand binding site [chemical binding]; other site 1138383011487 catalytic site [active] 1138383011488 NAD binding site [chemical binding]; other site 1138383011489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383011490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383011491 Rubredoxin [Energy production and conversion]; Region: COG1773 1138383011492 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138383011493 iron binding site [ion binding]; other site 1138383011494 Rubredoxin [Energy production and conversion]; Region: COG1773 1138383011495 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138383011496 iron binding site [ion binding]; other site 1138383011497 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1138383011498 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138383011499 Di-iron ligands [ion binding]; other site 1138383011500 amino acid transporter; Region: 2A0306; TIGR00909 1138383011501 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138383011502 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138383011503 hypothetical protein; Provisional; Region: PRK07236 1138383011504 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1138383011505 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138383011506 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138383011507 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1138383011508 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1138383011509 active site 1138383011510 substrate binding site [chemical binding]; other site 1138383011511 metal binding site [ion binding]; metal-binding site 1138383011512 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1138383011513 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1138383011514 Transcription factor WhiB; Region: Whib; pfam02467 1138383011515 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1138383011516 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1138383011517 phosphate binding site [ion binding]; other site 1138383011518 dimer interface [polypeptide binding]; other site 1138383011519 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1138383011520 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1138383011521 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1138383011522 FMN binding site [chemical binding]; other site 1138383011523 dimer interface [polypeptide binding]; other site 1138383011524 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1138383011525 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138383011526 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1138383011527 nudix motif; other site 1138383011528 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1138383011529 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1138383011530 active site 1138383011531 Substrate binding site; other site 1138383011532 Mg++ binding site; other site 1138383011533 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1138383011534 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138383011535 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1138383011536 Probable Catalytic site; other site 1138383011537 metal-binding site 1138383011538 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1138383011539 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138383011540 NADP binding site [chemical binding]; other site 1138383011541 active site 1138383011542 putative substrate binding site [chemical binding]; other site 1138383011543 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138383011544 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138383011545 TIGR03089 family protein; Region: TIGR03089 1138383011546 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138383011547 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138383011548 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138383011549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1138383011550 active site 1138383011551 motif I; other site 1138383011552 motif II; other site 1138383011553 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138383011554 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383011555 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383011556 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383011557 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383011558 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383011559 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383011560 active site 1138383011561 ATP binding site [chemical binding]; other site 1138383011562 substrate binding site [chemical binding]; other site 1138383011563 activation loop (A-loop); other site 1138383011564 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138383011565 NHL repeat; Region: NHL; pfam01436 1138383011566 NHL repeat; Region: NHL; pfam01436 1138383011567 NHL repeat; Region: NHL; pfam01436 1138383011568 NHL repeat; Region: NHL; pfam01436 1138383011569 NHL repeat; Region: NHL; pfam01436 1138383011570 PBP superfamily domain; Region: PBP_like_2; cl17296 1138383011571 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 1138383011572 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138383011573 Walker A/P-loop; other site 1138383011574 ATP binding site [chemical binding]; other site 1138383011575 Q-loop/lid; other site 1138383011576 ABC transporter signature motif; other site 1138383011577 Walker B; other site 1138383011578 D-loop; other site 1138383011579 H-loop/switch region; other site 1138383011580 PBP superfamily domain; Region: PBP_like_2; cl17296 1138383011581 PBP superfamily domain; Region: PBP_like_2; cl17296 1138383011582 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138383011583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383011584 dimer interface [polypeptide binding]; other site 1138383011585 conserved gate region; other site 1138383011586 putative PBP binding loops; other site 1138383011587 ABC-ATPase subunit interface; other site 1138383011588 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138383011589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138383011590 dimer interface [polypeptide binding]; other site 1138383011591 conserved gate region; other site 1138383011592 ABC-ATPase subunit interface; other site 1138383011593 Response regulator receiver domain; Region: Response_reg; pfam00072 1138383011594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383011595 active site 1138383011596 phosphorylation site [posttranslational modification] 1138383011597 intermolecular recognition site; other site 1138383011598 dimerization interface [polypeptide binding]; other site 1138383011599 CHASE3 domain; Region: CHASE3; pfam05227 1138383011600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383011601 dimer interface [polypeptide binding]; other site 1138383011602 phosphorylation site [posttranslational modification] 1138383011603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383011604 ATP binding site [chemical binding]; other site 1138383011605 Mg2+ binding site [ion binding]; other site 1138383011606 G-X-G motif; other site 1138383011607 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138383011608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383011609 active site 1138383011610 phosphorylation site [posttranslational modification] 1138383011611 intermolecular recognition site; other site 1138383011612 dimerization interface [polypeptide binding]; other site 1138383011613 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138383011614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383011615 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1138383011616 FAD binding site [chemical binding]; other site 1138383011617 homotetramer interface [polypeptide binding]; other site 1138383011618 substrate binding pocket [chemical binding]; other site 1138383011619 catalytic base [active] 1138383011620 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1138383011621 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1138383011622 ATP-grasp domain; Region: ATP-grasp; pfam02222 1138383011623 Predicted membrane protein [Function unknown]; Region: COG2246 1138383011624 GtrA-like protein; Region: GtrA; pfam04138 1138383011625 Bacterial PH domain; Region: DUF304; pfam03703 1138383011626 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1138383011627 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1138383011628 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1138383011629 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1138383011630 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138383011631 acyl-CoA synthetase; Provisional; Region: PRK13388 1138383011632 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383011633 acyl-activating enzyme (AAE) consensus motif; other site 1138383011634 AMP binding site [chemical binding]; other site 1138383011635 active site 1138383011636 CoA binding site [chemical binding]; other site 1138383011637 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383011638 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138383011639 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138383011640 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138383011641 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138383011642 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1138383011643 active site 1138383011644 dimer interface [polypeptide binding]; other site 1138383011645 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138383011646 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138383011647 active site residue [active] 1138383011648 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138383011649 active site residue [active] 1138383011650 Fe-S metabolism associated domain; Region: SufE; cl00951 1138383011651 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1138383011652 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138383011653 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138383011654 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138383011655 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138383011656 carboxyltransferase (CT) interaction site; other site 1138383011657 biotinylation site [posttranslational modification]; other site 1138383011658 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383011659 anti sigma factor interaction site; other site 1138383011660 regulatory phosphorylation site [posttranslational modification]; other site 1138383011661 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1138383011662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383011663 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138383011664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383011665 DNA binding residues [nucleotide binding] 1138383011666 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138383011667 L-lysine aminotransferase; Provisional; Region: PRK08297 1138383011668 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138383011669 inhibitor-cofactor binding pocket; inhibition site 1138383011670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383011671 catalytic residue [active] 1138383011672 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1138383011673 AsnC family; Region: AsnC_trans_reg; pfam01037 1138383011674 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1138383011675 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138383011676 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383011677 NAD(P) binding site [chemical binding]; other site 1138383011678 catalytic residues [active] 1138383011679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383011680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138383011681 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1138383011682 ATP binding site [chemical binding]; other site 1138383011683 putative Mg++ binding site [ion binding]; other site 1138383011684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138383011685 nucleotide binding region [chemical binding]; other site 1138383011686 ATP-binding site [chemical binding]; other site 1138383011687 DEAD/H associated; Region: DEAD_assoc; pfam08494 1138383011688 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138383011689 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1138383011690 putative DNA binding site [nucleotide binding]; other site 1138383011691 catalytic residue [active] 1138383011692 putative H2TH interface [polypeptide binding]; other site 1138383011693 putative catalytic residues [active] 1138383011694 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138383011695 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138383011696 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138383011697 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383011698 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1138383011699 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1138383011700 oligomer interface [polypeptide binding]; other site 1138383011701 metal binding site [ion binding]; metal-binding site 1138383011702 metal binding site [ion binding]; metal-binding site 1138383011703 putative Cl binding site [ion binding]; other site 1138383011704 aspartate ring; other site 1138383011705 basic sphincter; other site 1138383011706 hydrophobic gate; other site 1138383011707 periplasmic entrance; other site 1138383011708 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383011709 PPE family; Region: PPE; pfam00823 1138383011710 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383011711 PPE family; Region: PPE; pfam00823 1138383011712 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138383011713 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138383011714 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1138383011715 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1138383011716 active site 1138383011717 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1138383011718 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1138383011719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383011720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383011721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383011722 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138383011723 putative active site pocket [active] 1138383011724 dimerization interface [polypeptide binding]; other site 1138383011725 putative catalytic residue [active] 1138383011726 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383011727 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383011728 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1138383011729 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1138383011730 metal binding site [ion binding]; metal-binding site 1138383011731 putative dimer interface [polypeptide binding]; other site 1138383011732 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1138383011733 amidohydrolase; Region: amidohydrolases; TIGR01891 1138383011734 metal binding site [ion binding]; metal-binding site 1138383011735 Cutinase; Region: Cutinase; pfam01083 1138383011736 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1138383011737 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1138383011738 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1138383011739 active site 1138383011740 substrate binding site [chemical binding]; other site 1138383011741 metal binding site [ion binding]; metal-binding site 1138383011742 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138383011743 hypothetical protein; Provisional; Region: PRK13685 1138383011744 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1138383011745 metal ion-dependent adhesion site (MIDAS); other site 1138383011746 hypothetical protein; Provisional; Region: PRK13685 1138383011747 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1138383011748 metal ion-dependent adhesion site (MIDAS); other site 1138383011749 Cupin domain; Region: Cupin_2; cl17218 1138383011750 Cupin domain; Region: Cupin_2; pfam07883 1138383011751 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138383011752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383011753 DNA-binding site [nucleotide binding]; DNA binding site 1138383011754 FCD domain; Region: FCD; pfam07729 1138383011755 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1138383011756 adenosine deaminase; Provisional; Region: PRK09358 1138383011757 active site 1138383011758 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1138383011759 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1138383011760 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1138383011761 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1138383011762 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1138383011763 active site 1138383011764 catalytic motif [active] 1138383011765 Zn binding site [ion binding]; other site 1138383011766 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1138383011767 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138383011768 putative proximal heme binding site [chemical binding]; other site 1138383011769 putative SdhD-like interface [polypeptide binding]; other site 1138383011770 putative distal heme binding site [chemical binding]; other site 1138383011771 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1138383011772 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138383011773 putative proximal heme binding site [chemical binding]; other site 1138383011774 putative SdhC-like subunit interface [polypeptide binding]; other site 1138383011775 putative distal heme binding site [chemical binding]; other site 1138383011776 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1138383011777 L-aspartate oxidase; Provisional; Region: PRK06175 1138383011778 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138383011779 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1138383011780 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1138383011781 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383011782 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138383011783 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1138383011784 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138383011785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383011786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383011787 DNA binding residues [nucleotide binding] 1138383011788 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383011789 hypothetical protein; Provisional; Region: PRK06541 1138383011790 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138383011791 inhibitor-cofactor binding pocket; inhibition site 1138383011792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383011793 catalytic residue [active] 1138383011794 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138383011795 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138383011796 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1138383011797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383011798 putative substrate translocation pore; other site 1138383011799 Amidohydrolase; Region: Amidohydro_4; pfam13147 1138383011800 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383011801 active site 1138383011802 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1138383011803 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1138383011804 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1138383011805 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1138383011806 active site 1138383011807 HIGH motif; other site 1138383011808 dimer interface [polypeptide binding]; other site 1138383011809 KMSKS motif; other site 1138383011810 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383011811 isocitrate dehydrogenase; Validated; Region: PRK08299 1138383011812 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1138383011813 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1138383011814 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1138383011815 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138383011816 homodimer interface [polypeptide binding]; other site 1138383011817 substrate-cofactor binding pocket; other site 1138383011818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383011819 catalytic residue [active] 1138383011820 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1138383011821 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1138383011822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383011823 S-adenosylmethionine binding site [chemical binding]; other site 1138383011824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383011825 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1138383011826 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383011827 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383011828 active site 1138383011829 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383011830 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1138383011831 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1138383011832 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1138383011833 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1138383011834 homodimer interface [polypeptide binding]; other site 1138383011835 NADP binding site [chemical binding]; other site 1138383011836 substrate binding site [chemical binding]; other site 1138383011837 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138383011838 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138383011839 active site 1138383011840 FMN binding site [chemical binding]; other site 1138383011841 substrate binding site [chemical binding]; other site 1138383011842 putative catalytic residue [active] 1138383011843 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383011844 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383011845 phosphopeptide binding site; other site 1138383011846 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383011847 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383011848 phosphopeptide binding site; other site 1138383011849 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138383011850 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138383011851 Walker A/P-loop; other site 1138383011852 ATP binding site [chemical binding]; other site 1138383011853 Q-loop/lid; other site 1138383011854 ABC transporter signature motif; other site 1138383011855 Walker B; other site 1138383011856 D-loop; other site 1138383011857 H-loop/switch region; other site 1138383011858 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138383011859 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138383011860 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383011861 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383011862 phosphopeptide binding site; other site 1138383011863 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138383011864 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138383011865 phosphopeptide binding site; other site 1138383011866 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138383011867 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138383011868 Walker A/P-loop; other site 1138383011869 ATP binding site [chemical binding]; other site 1138383011870 Q-loop/lid; other site 1138383011871 ABC transporter signature motif; other site 1138383011872 Walker B; other site 1138383011873 D-loop; other site 1138383011874 H-loop/switch region; other site 1138383011875 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138383011876 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1138383011877 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1138383011878 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138383011879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138383011880 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1138383011881 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1138383011882 G1 box; other site 1138383011883 GTP/Mg2+ binding site [chemical binding]; other site 1138383011884 G2 box; other site 1138383011885 Switch I region; other site 1138383011886 G3 box; other site 1138383011887 Switch II region; other site 1138383011888 G4 box; other site 1138383011889 G5 box; other site 1138383011890 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1138383011891 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1138383011892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383011893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383011894 ATP binding site [chemical binding]; other site 1138383011895 Mg2+ binding site [ion binding]; other site 1138383011896 G-X-G motif; other site 1138383011897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383011898 S-adenosylmethionine binding site [chemical binding]; other site 1138383011899 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1138383011900 YCII-related domain; Region: YCII; cl00999 1138383011901 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138383011902 FMN binding site [chemical binding]; other site 1138383011903 dimer interface [polypeptide binding]; other site 1138383011904 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1138383011905 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1138383011906 active site 1138383011907 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138383011908 generic binding surface II; other site 1138383011909 generic binding surface I; other site 1138383011910 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1138383011911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383011912 active site 1138383011913 motif I; other site 1138383011914 motif II; other site 1138383011915 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383011916 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138383011917 dimer interaction site [polypeptide binding]; other site 1138383011918 substrate-binding tunnel; other site 1138383011919 active site 1138383011920 catalytic site [active] 1138383011921 substrate binding site [chemical binding]; other site 1138383011922 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383011923 catalytic core [active] 1138383011924 short chain dehydrogenase; Provisional; Region: PRK07201 1138383011925 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1138383011926 putative NAD(P) binding site [chemical binding]; other site 1138383011927 active site 1138383011928 putative substrate binding site [chemical binding]; other site 1138383011929 classical (c) SDRs; Region: SDR_c; cd05233 1138383011930 NAD(P) binding site [chemical binding]; other site 1138383011931 active site 1138383011932 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383011933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383011934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383011935 S-adenosylmethionine binding site [chemical binding]; other site 1138383011936 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1138383011937 active site 1138383011938 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138383011939 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138383011940 dimer interface [polypeptide binding]; other site 1138383011941 active site 1138383011942 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1138383011943 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1138383011944 putative active site [active] 1138383011945 putative substrate binding site [chemical binding]; other site 1138383011946 putative FMN binding site [chemical binding]; other site 1138383011947 putative catalytic residues [active] 1138383011948 DNA Polymerase Y-family; Region: PolY_like; cd03468 1138383011949 DNA binding site [nucleotide binding] 1138383011950 GMP synthase; Reviewed; Region: guaA; PRK00074 1138383011951 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1138383011952 AMP/PPi binding site [chemical binding]; other site 1138383011953 candidate oxyanion hole; other site 1138383011954 catalytic triad [active] 1138383011955 potential glutamine specificity residues [chemical binding]; other site 1138383011956 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1138383011957 ATP Binding subdomain [chemical binding]; other site 1138383011958 Ligand Binding sites [chemical binding]; other site 1138383011959 Dimerization subdomain; other site 1138383011960 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383011961 PPE family; Region: PPE; pfam00823 1138383011962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383011963 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1138383011964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383011965 motif II; other site 1138383011966 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1138383011967 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1138383011968 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1138383011969 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1138383011970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383011971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383011972 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1138383011973 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138383011974 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1138383011975 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138383011976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138383011977 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138383011978 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1138383011979 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138383011980 phosphate binding site [ion binding]; other site 1138383011981 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1138383011982 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138383011983 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1138383011984 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138383011985 active site 1138383011986 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1138383011987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383011988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1138383011989 DNA binding residues [nucleotide binding] 1138383011990 Transcription factor WhiB; Region: Whib; pfam02467 1138383011991 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138383011992 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138383011993 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1138383011994 [2Fe-2S] cluster binding site [ion binding]; other site 1138383011995 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383011996 Fe binding site [ion binding]; other site 1138383011997 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1138383011998 E-class dimer interface [polypeptide binding]; other site 1138383011999 P-class dimer interface [polypeptide binding]; other site 1138383012000 active site 1138383012001 Cu2+ binding site [ion binding]; other site 1138383012002 Zn2+ binding site [ion binding]; other site 1138383012003 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1138383012004 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138383012005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383012006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012007 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138383012008 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138383012009 ring oligomerisation interface [polypeptide binding]; other site 1138383012010 ATP/Mg binding site [chemical binding]; other site 1138383012011 stacking interactions; other site 1138383012012 hinge regions; other site 1138383012013 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1138383012014 oligomerisation interface [polypeptide binding]; other site 1138383012015 mobile loop; other site 1138383012016 roof hairpin; other site 1138383012017 UGMP family protein; Validated; Region: PRK09604 1138383012018 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1138383012019 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1138383012020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383012021 Coenzyme A binding pocket [chemical binding]; other site 1138383012022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138383012023 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1138383012024 Glycoprotease family; Region: Peptidase_M22; pfam00814 1138383012025 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1138383012026 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383012027 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383012028 alanine racemase; Reviewed; Region: alr; PRK00053 1138383012029 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1138383012030 active site 1138383012031 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138383012032 dimer interface [polypeptide binding]; other site 1138383012033 substrate binding site [chemical binding]; other site 1138383012034 catalytic residues [active] 1138383012035 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1138383012036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383012037 catalytic residue [active] 1138383012038 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1138383012039 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1138383012040 putative substrate binding site [chemical binding]; other site 1138383012041 putative ATP binding site [chemical binding]; other site 1138383012042 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1138383012043 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1138383012044 glutaminase active site [active] 1138383012045 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1138383012046 dimer interface [polypeptide binding]; other site 1138383012047 active site 1138383012048 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1138383012049 dimer interface [polypeptide binding]; other site 1138383012050 active site 1138383012051 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383012052 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138383012053 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383012054 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1138383012055 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1138383012056 active site 1138383012057 substrate binding site [chemical binding]; other site 1138383012058 metal binding site [ion binding]; metal-binding site 1138383012059 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1138383012060 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1138383012061 23S rRNA interface [nucleotide binding]; other site 1138383012062 L3 interface [polypeptide binding]; other site 1138383012063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138383012064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138383012065 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1138383012066 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138383012067 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383012068 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138383012069 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383012070 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383012071 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1138383012072 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138383012073 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138383012074 active site 1138383012075 catalytic residues [active] 1138383012076 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1138383012077 Cutinase; Region: Cutinase; pfam01083 1138383012078 Cutinase; Region: Cutinase; pfam01083 1138383012079 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1138383012080 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1138383012081 active site 1138383012082 dimerization interface 3.5A [polypeptide binding]; other site 1138383012083 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1138383012084 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1138383012085 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1138383012086 alphaNTD homodimer interface [polypeptide binding]; other site 1138383012087 alphaNTD - beta interaction site [polypeptide binding]; other site 1138383012088 alphaNTD - beta' interaction site [polypeptide binding]; other site 1138383012089 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1138383012090 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1138383012091 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1138383012092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138383012093 RNA binding surface [nucleotide binding]; other site 1138383012094 30S ribosomal protein S11; Validated; Region: PRK05309 1138383012095 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1138383012096 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1138383012097 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1138383012098 rRNA binding site [nucleotide binding]; other site 1138383012099 predicted 30S ribosome binding site; other site 1138383012100 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138383012101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383012102 active site 1138383012103 phosphorylation site [posttranslational modification] 1138383012104 intermolecular recognition site; other site 1138383012105 dimerization interface [polypeptide binding]; other site 1138383012106 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138383012107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383012108 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138383012109 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138383012110 ligand binding site [chemical binding]; other site 1138383012111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138383012112 flexible hinge region; other site 1138383012113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383012114 ATP binding site [chemical binding]; other site 1138383012115 Mg2+ binding site [ion binding]; other site 1138383012116 G-X-G motif; other site 1138383012117 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138383012118 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138383012119 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138383012120 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1138383012121 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1138383012122 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1138383012123 NAD binding site [chemical binding]; other site 1138383012124 substrate binding site [chemical binding]; other site 1138383012125 homodimer interface [polypeptide binding]; other site 1138383012126 active site 1138383012127 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1138383012128 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383012129 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138383012130 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383012131 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138383012132 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1138383012133 active site 1138383012134 metal binding site [ion binding]; metal-binding site 1138383012135 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1138383012136 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1138383012137 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138383012138 iron-sulfur cluster [ion binding]; other site 1138383012139 [2Fe-2S] cluster binding site [ion binding]; other site 1138383012140 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1138383012141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383012142 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383012143 DNA binding residues [nucleotide binding] 1138383012144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383012145 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1138383012146 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1138383012147 tetrameric interface [polypeptide binding]; other site 1138383012148 NAD binding site [chemical binding]; other site 1138383012149 catalytic residues [active] 1138383012150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383012151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383012152 active site 1138383012153 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138383012154 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1138383012155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383012156 MarR family; Region: MarR; pfam01047 1138383012157 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1138383012158 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383012159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383012160 homodimer interface [polypeptide binding]; other site 1138383012161 catalytic residue [active] 1138383012162 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1138383012163 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1138383012164 active site 1138383012165 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776 1138383012166 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1138383012167 PYR/PP interface [polypeptide binding]; other site 1138383012168 dimer interface [polypeptide binding]; other site 1138383012169 TPP binding site [chemical binding]; other site 1138383012170 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1138383012171 TPP-binding site [chemical binding]; other site 1138383012172 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138383012173 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1138383012174 Walker A/P-loop; other site 1138383012175 ATP binding site [chemical binding]; other site 1138383012176 Q-loop/lid; other site 1138383012177 ABC transporter signature motif; other site 1138383012178 Walker B; other site 1138383012179 D-loop; other site 1138383012180 H-loop/switch region; other site 1138383012181 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1138383012182 FtsX-like permease family; Region: FtsX; pfam02687 1138383012183 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138383012184 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1138383012185 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138383012186 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383012187 Putative zinc-finger; Region: zf-HC2; pfam13490 1138383012188 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1138383012189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383012190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383012191 DNA binding residues [nucleotide binding] 1138383012192 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138383012193 active site 1138383012194 adenylate kinase; Reviewed; Region: adk; PRK00279 1138383012195 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1138383012196 AMP-binding site [chemical binding]; other site 1138383012197 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1138383012198 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1138383012199 SecY translocase; Region: SecY; pfam00344 1138383012200 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383012201 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383012202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138383012203 Coenzyme A binding pocket [chemical binding]; other site 1138383012204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383012205 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1138383012206 nucleotide binding site [chemical binding]; other site 1138383012207 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1138383012208 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1138383012209 NAD binding site [chemical binding]; other site 1138383012210 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1138383012211 intersubunit interface [polypeptide binding]; other site 1138383012212 active site 1138383012213 Zn2+ binding site [ion binding]; other site 1138383012214 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383012215 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138383012216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383012217 NAD(P) binding site [chemical binding]; other site 1138383012218 classical (c) SDRs; Region: SDR_c; cd05233 1138383012219 NAD(P) binding site [chemical binding]; other site 1138383012220 active site 1138383012221 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383012222 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383012223 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383012224 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383012225 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383012226 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383012227 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1138383012228 tandem repeat interface [polypeptide binding]; other site 1138383012229 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138383012230 oligomer interface [polypeptide binding]; other site 1138383012231 active site residues [active] 1138383012232 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138383012233 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1138383012234 tandem repeat interface [polypeptide binding]; other site 1138383012235 oligomer interface [polypeptide binding]; other site 1138383012236 active site residues [active] 1138383012237 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383012238 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383012239 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1138383012240 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1138383012241 23S rRNA binding site [nucleotide binding]; other site 1138383012242 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1138383012243 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1138383012244 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1138383012245 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1138383012246 5S rRNA interface [nucleotide binding]; other site 1138383012247 L27 interface [polypeptide binding]; other site 1138383012248 23S rRNA interface [nucleotide binding]; other site 1138383012249 L5 interface [polypeptide binding]; other site 1138383012250 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1138383012251 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138383012252 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138383012253 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1138383012254 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1138383012255 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1138383012256 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1138383012257 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1138383012258 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1138383012259 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1138383012260 RNA binding site [nucleotide binding]; other site 1138383012261 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1138383012262 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383012263 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383012264 active site 1138383012265 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138383012266 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1138383012267 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138383012268 Sulfatase; Region: Sulfatase; pfam00884 1138383012269 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1138383012270 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1138383012271 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1138383012272 putative translocon interaction site; other site 1138383012273 signal recognition particle (SRP54) interaction site; other site 1138383012274 L23 interface [polypeptide binding]; other site 1138383012275 trigger factor interaction site; other site 1138383012276 23S rRNA interface [nucleotide binding]; other site 1138383012277 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1138383012278 23S rRNA interface [nucleotide binding]; other site 1138383012279 5S rRNA interface [nucleotide binding]; other site 1138383012280 putative antibiotic binding site [chemical binding]; other site 1138383012281 L25 interface [polypeptide binding]; other site 1138383012282 L27 interface [polypeptide binding]; other site 1138383012283 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1138383012284 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1138383012285 G-X-X-G motif; other site 1138383012286 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1138383012287 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1138383012288 putative translocon binding site; other site 1138383012289 protein-rRNA interface [nucleotide binding]; other site 1138383012290 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1138383012291 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1138383012292 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1138383012293 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1138383012294 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1138383012295 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1138383012296 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1138383012297 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1138383012298 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383012299 Cytochrome P450; Region: p450; cl12078 1138383012300 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1138383012301 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138383012302 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1138383012303 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138383012304 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1138383012305 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1138383012306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138383012307 phosphate binding site [ion binding]; other site 1138383012308 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1138383012309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138383012310 FeS/SAM binding site; other site 1138383012311 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1138383012312 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1138383012313 mycofactocin precursor; Region: mycofactocin; TIGR03969 1138383012314 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383012315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012316 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1138383012317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383012318 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383012319 active site 1138383012320 catalytic tetrad [active] 1138383012321 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1138383012322 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138383012323 active site 1138383012324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1138383012325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383012326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383012327 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383012328 classical (c) SDRs; Region: SDR_c; cd05233 1138383012329 NAD(P) binding site [chemical binding]; other site 1138383012330 active site 1138383012331 Short C-terminal domain; Region: SHOCT; pfam09851 1138383012332 PE family; Region: PE; pfam00934 1138383012333 elongation factor Tu; Reviewed; Region: PRK00049 1138383012334 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1138383012335 G1 box; other site 1138383012336 GEF interaction site [polypeptide binding]; other site 1138383012337 GTP/Mg2+ binding site [chemical binding]; other site 1138383012338 Switch I region; other site 1138383012339 G2 box; other site 1138383012340 G3 box; other site 1138383012341 Switch II region; other site 1138383012342 G4 box; other site 1138383012343 G5 box; other site 1138383012344 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1138383012345 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1138383012346 Antibiotic Binding Site [chemical binding]; other site 1138383012347 elongation factor G; Reviewed; Region: PRK00007 1138383012348 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1138383012349 G1 box; other site 1138383012350 putative GEF interaction site [polypeptide binding]; other site 1138383012351 GTP/Mg2+ binding site [chemical binding]; other site 1138383012352 Switch I region; other site 1138383012353 G2 box; other site 1138383012354 G3 box; other site 1138383012355 Switch II region; other site 1138383012356 G4 box; other site 1138383012357 G5 box; other site 1138383012358 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138383012359 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138383012360 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138383012361 30S ribosomal protein S7; Validated; Region: PRK05302 1138383012362 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1138383012363 S17 interaction site [polypeptide binding]; other site 1138383012364 S8 interaction site; other site 1138383012365 16S rRNA interaction site [nucleotide binding]; other site 1138383012366 streptomycin interaction site [chemical binding]; other site 1138383012367 23S rRNA interaction site [nucleotide binding]; other site 1138383012368 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1138383012369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383012370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012371 WHG domain; Region: WHG; pfam13305 1138383012372 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138383012373 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138383012374 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383012375 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383012376 substrate binding site [chemical binding]; other site 1138383012377 oxyanion hole (OAH) forming residues; other site 1138383012378 trimer interface [polypeptide binding]; other site 1138383012379 PaaX-like protein; Region: PaaX; pfam07848 1138383012380 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1138383012381 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138383012382 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383012383 substrate binding site [chemical binding]; other site 1138383012384 oxyanion hole (OAH) forming residues; other site 1138383012385 trimer interface [polypeptide binding]; other site 1138383012386 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1138383012387 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383012388 active site 1138383012389 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138383012390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383012391 endonuclease IV; Provisional; Region: PRK01060 1138383012392 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1138383012393 AP (apurinic/apyrimidinic) site pocket; other site 1138383012394 DNA interaction; other site 1138383012395 Metal-binding active site; metal-binding site 1138383012396 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1138383012397 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1138383012398 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1138383012399 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1138383012400 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1138383012401 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1138383012402 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138383012403 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1138383012404 G-loop; other site 1138383012405 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138383012406 DNA binding site [nucleotide binding] 1138383012407 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1138383012408 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1138383012409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1138383012410 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1138383012411 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138383012412 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138383012413 RPB10 interaction site [polypeptide binding]; other site 1138383012414 RPB1 interaction site [polypeptide binding]; other site 1138383012415 RPB11 interaction site [polypeptide binding]; other site 1138383012416 RPB3 interaction site [polypeptide binding]; other site 1138383012417 RPB12 interaction site [polypeptide binding]; other site 1138383012418 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1138383012419 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1138383012420 Walker A/P-loop; other site 1138383012421 ATP binding site [chemical binding]; other site 1138383012422 Q-loop/lid; other site 1138383012423 ABC transporter signature motif; other site 1138383012424 Walker B; other site 1138383012425 D-loop; other site 1138383012426 H-loop/switch region; other site 1138383012427 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138383012428 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138383012429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383012430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012431 WHG domain; Region: WHG; pfam13305 1138383012432 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1138383012433 core dimer interface [polypeptide binding]; other site 1138383012434 peripheral dimer interface [polypeptide binding]; other site 1138383012435 L10 interface [polypeptide binding]; other site 1138383012436 L11 interface [polypeptide binding]; other site 1138383012437 putative EF-Tu interaction site [polypeptide binding]; other site 1138383012438 putative EF-G interaction site [polypeptide binding]; other site 1138383012439 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1138383012440 23S rRNA interface [nucleotide binding]; other site 1138383012441 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1138383012442 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138383012443 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383012444 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1138383012445 active site 1138383012446 catalytic site [active] 1138383012447 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1138383012448 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1138383012449 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1138383012450 DinB superfamily; Region: DinB_2; pfam12867 1138383012451 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138383012452 DinB superfamily; Region: DinB_2; pfam12867 1138383012453 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138383012454 ABC1 family; Region: ABC1; pfam03109 1138383012455 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1138383012456 active site 1138383012457 ATP binding site [chemical binding]; other site 1138383012458 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383012459 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138383012460 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383012461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012462 S-adenosylmethionine binding site [chemical binding]; other site 1138383012463 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383012464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012465 S-adenosylmethionine binding site [chemical binding]; other site 1138383012466 YCII-related domain; Region: YCII; cl00999 1138383012467 YCII-related domain; Region: YCII; cl00999 1138383012468 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1138383012469 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383012470 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138383012471 DNA binding residues [nucleotide binding] 1138383012472 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1138383012473 mRNA/rRNA interface [nucleotide binding]; other site 1138383012474 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1138383012475 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1138383012476 23S rRNA interface [nucleotide binding]; other site 1138383012477 L7/L12 interface [polypeptide binding]; other site 1138383012478 putative thiostrepton binding site; other site 1138383012479 L25 interface [polypeptide binding]; other site 1138383012480 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1138383012481 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1138383012482 putative homodimer interface [polypeptide binding]; other site 1138383012483 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1138383012484 heterodimer interface [polypeptide binding]; other site 1138383012485 homodimer interface [polypeptide binding]; other site 1138383012486 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1138383012487 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138383012488 active site 1138383012489 catalytic site [active] 1138383012490 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1138383012491 active site 1138383012492 catalytic site [active] 1138383012493 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138383012494 active site 1138383012495 catalytic site [active] 1138383012496 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1138383012497 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1138383012498 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138383012499 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383012500 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383012501 substrate binding site [chemical binding]; other site 1138383012502 oxyanion hole (OAH) forming residues; other site 1138383012503 trimer interface [polypeptide binding]; other site 1138383012504 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1138383012505 [4Fe-4S] binding site [ion binding]; other site 1138383012506 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1138383012507 molybdopterin cofactor binding site; other site 1138383012508 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1138383012509 molybdopterin cofactor binding site; other site 1138383012510 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138383012511 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1138383012512 active site 1138383012513 nucleophile elbow; other site 1138383012514 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1138383012515 cyanate hydratase; Validated; Region: PRK02866 1138383012516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1138383012517 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1138383012518 oligomer interface [polypeptide binding]; other site 1138383012519 active site 1138383012520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012521 S-adenosylmethionine binding site [chemical binding]; other site 1138383012522 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1138383012523 putative FMN binding site [chemical binding]; other site 1138383012524 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383012525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012526 S-adenosylmethionine binding site [chemical binding]; other site 1138383012527 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1138383012528 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1138383012529 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1138383012530 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1138383012531 Part of AAA domain; Region: AAA_19; pfam13245 1138383012532 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1138383012533 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1138383012534 AAA domain; Region: AAA_30; pfam13604 1138383012535 Family description; Region: UvrD_C_2; pfam13538 1138383012536 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138383012537 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138383012538 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383012539 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383012540 active site 1138383012541 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383012542 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383012543 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1138383012544 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1138383012545 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1138383012546 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138383012547 PAS fold; Region: PAS_3; pfam08447 1138383012548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1138383012549 putative active site [active] 1138383012550 heme pocket [chemical binding]; other site 1138383012551 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383012552 galactokinase; Provisional; Region: PRK00555 1138383012553 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1138383012554 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1138383012555 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1138383012556 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1138383012557 dimer interface [polypeptide binding]; other site 1138383012558 active site 1138383012559 Predicted membrane protein [Function unknown]; Region: COG1289 1138383012560 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1138383012561 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383012562 Cytochrome P450; Region: p450; cl12078 1138383012563 hypothetical protein; Provisional; Region: PRK07588 1138383012564 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383012565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383012566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383012567 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138383012568 NYN domain; Region: NYN; pfam01936 1138383012569 putative metal binding site [ion binding]; other site 1138383012570 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1138383012571 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383012572 Cytochrome P450; Region: p450; cl12078 1138383012573 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138383012574 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138383012575 Integrase core domain; Region: rve; pfam00665 1138383012576 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138383012577 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138383012578 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138383012579 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383012580 molybdopterin cofactor binding site; other site 1138383012581 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 1138383012582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1138383012583 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1138383012584 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383012585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383012586 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1138383012587 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138383012588 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138383012589 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138383012590 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1138383012591 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138383012592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383012593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383012594 salt bridge; other site 1138383012595 non-specific DNA binding site [nucleotide binding]; other site 1138383012596 sequence-specific DNA binding site [nucleotide binding]; other site 1138383012597 heat shock protein HtpX; Provisional; Region: PRK03072 1138383012598 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138383012599 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138383012600 substrate binding pocket [chemical binding]; other site 1138383012601 chain length determination region; other site 1138383012602 substrate-Mg2+ binding site; other site 1138383012603 catalytic residues [active] 1138383012604 aspartate-rich region 1; other site 1138383012605 active site lid residues [active] 1138383012606 aspartate-rich region 2; other site 1138383012607 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1138383012608 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138383012609 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383012610 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1138383012611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012612 S-adenosylmethionine binding site [chemical binding]; other site 1138383012613 short chain dehydrogenase; Provisional; Region: PRK08263 1138383012614 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138383012615 NADP binding site [chemical binding]; other site 1138383012616 active site 1138383012617 steroid binding site; other site 1138383012618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383012619 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138383012620 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1138383012621 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1138383012622 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1138383012623 dimer interface [polypeptide binding]; other site 1138383012624 tetramer interface [polypeptide binding]; other site 1138383012625 PYR/PP interface [polypeptide binding]; other site 1138383012626 TPP binding site [chemical binding]; other site 1138383012627 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1138383012628 TPP-binding site; other site 1138383012629 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1138383012630 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383012631 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138383012632 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1138383012633 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1138383012634 active site 1138383012635 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138383012636 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138383012637 active site 1138383012638 acyl-CoA synthetase; Validated; Region: PRK06188 1138383012639 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383012640 putative active site [active] 1138383012641 putative CoA binding site [chemical binding]; other site 1138383012642 putative AMP binding site [chemical binding]; other site 1138383012643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383012644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012645 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138383012646 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138383012647 active site 1138383012648 catalytic tetrad [active] 1138383012649 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138383012650 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383012651 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1138383012652 substrate binding site [chemical binding]; other site 1138383012653 oxyanion hole (OAH) forming residues; other site 1138383012654 trimer interface [polypeptide binding]; other site 1138383012655 short chain dehydrogenase; Provisional; Region: PRK05866 1138383012656 classical (c) SDRs; Region: SDR_c; cd05233 1138383012657 NAD(P) binding site [chemical binding]; other site 1138383012658 active site 1138383012659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383012660 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138383012661 active site 1138383012662 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1138383012663 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138383012664 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1138383012665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383012666 acyl-activating enzyme (AAE) consensus motif; other site 1138383012667 AMP binding site [chemical binding]; other site 1138383012668 active site 1138383012669 CoA binding site [chemical binding]; other site 1138383012670 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1138383012671 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1138383012672 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138383012673 Ligand binding site; other site 1138383012674 Putative Catalytic site; other site 1138383012675 DXD motif; other site 1138383012676 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383012677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383012678 NAD(P) binding site [chemical binding]; other site 1138383012679 active site 1138383012680 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1138383012681 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1138383012682 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138383012683 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1138383012684 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1138383012685 dimer interface [polypeptide binding]; other site 1138383012686 active site 1138383012687 CoA binding pocket [chemical binding]; other site 1138383012688 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138383012689 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138383012690 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138383012691 P-loop; other site 1138383012692 Magnesium ion binding site [ion binding]; other site 1138383012693 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1138383012694 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1138383012695 ResB-like family; Region: ResB; pfam05140 1138383012696 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138383012697 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138383012698 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138383012699 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138383012700 catalytic residues [active] 1138383012701 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383012702 catalytic core [active] 1138383012703 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1138383012704 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138383012705 inhibitor-cofactor binding pocket; inhibition site 1138383012706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383012707 catalytic residue [active] 1138383012708 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138383012709 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1138383012710 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138383012711 metal binding site [ion binding]; metal-binding site 1138383012712 substrate binding pocket [chemical binding]; other site 1138383012713 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1138383012714 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1138383012715 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1138383012716 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138383012717 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383012718 acyl-activating enzyme (AAE) consensus motif; other site 1138383012719 AMP binding site [chemical binding]; other site 1138383012720 active site 1138383012721 CoA binding site [chemical binding]; other site 1138383012722 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138383012723 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138383012724 putative NAD(P) binding site [chemical binding]; other site 1138383012725 active site 1138383012726 putative substrate binding site [chemical binding]; other site 1138383012727 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138383012728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383012729 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138383012730 putative substrate translocation pore; other site 1138383012731 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1138383012732 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1138383012733 active site 1138383012734 dimer interface [polypeptide binding]; other site 1138383012735 non-prolyl cis peptide bond; other site 1138383012736 insertion regions; other site 1138383012737 Putative esterase; Region: Esterase; pfam00756 1138383012738 S-formylglutathione hydrolase; Region: PLN02442 1138383012739 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383012740 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138383012741 active site 1138383012742 catalytic triad [active] 1138383012743 oxyanion hole [active] 1138383012744 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383012745 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383012746 anti sigma factor interaction site; other site 1138383012747 regulatory phosphorylation site [posttranslational modification]; other site 1138383012748 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1138383012749 dimer interface [polypeptide binding]; other site 1138383012750 active site 1138383012751 Schiff base residues; other site 1138383012752 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1138383012753 active site 1138383012754 homodimer interface [polypeptide binding]; other site 1138383012755 SAM binding site [chemical binding]; other site 1138383012756 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1138383012757 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138383012758 active site 1138383012759 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1138383012760 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1138383012761 domain interfaces; other site 1138383012762 active site 1138383012763 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1138383012764 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1138383012765 tRNA; other site 1138383012766 putative tRNA binding site [nucleotide binding]; other site 1138383012767 putative NADP binding site [chemical binding]; other site 1138383012768 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1138383012769 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1138383012770 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138383012771 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138383012772 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1138383012773 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138383012774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383012775 motif II; other site 1138383012776 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138383012777 active site 1138383012778 catalytic site [active] 1138383012779 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383012780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138383012781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012782 S-adenosylmethionine binding site [chemical binding]; other site 1138383012783 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138383012784 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138383012785 putative acyl-acceptor binding pocket; other site 1138383012786 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138383012787 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1138383012788 putative NAD(P) binding site [chemical binding]; other site 1138383012789 active site 1138383012790 putative substrate binding site [chemical binding]; other site 1138383012791 DNA binding domain, excisionase family; Region: excise; TIGR01764 1138383012792 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1138383012793 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1138383012794 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1138383012795 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138383012796 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383012797 CoenzymeA binding site [chemical binding]; other site 1138383012798 subunit interaction site [polypeptide binding]; other site 1138383012799 PHB binding site; other site 1138383012800 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1138383012801 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138383012802 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1138383012803 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1138383012804 DNA interaction; other site 1138383012805 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138383012806 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138383012807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138383012808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383012809 active site 1138383012810 phosphorylation site [posttranslational modification] 1138383012811 intermolecular recognition site; other site 1138383012812 dimerization interface [polypeptide binding]; other site 1138383012813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138383012814 DNA binding site [nucleotide binding] 1138383012815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138383012816 dimer interface [polypeptide binding]; other site 1138383012817 phosphorylation site [posttranslational modification] 1138383012818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138383012819 ATP binding site [chemical binding]; other site 1138383012820 Mg2+ binding site [ion binding]; other site 1138383012821 G-X-G motif; other site 1138383012822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383012823 catalytic core [active] 1138383012824 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138383012825 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1138383012826 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1138383012827 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1138383012828 putative ADP-binding pocket [chemical binding]; other site 1138383012829 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138383012830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383012831 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138383012832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383012833 NAD(P) binding site [chemical binding]; other site 1138383012834 active site 1138383012835 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138383012836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138383012837 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138383012838 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138383012839 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1138383012840 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383012841 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1138383012842 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1138383012843 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1138383012844 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1138383012845 putative active site [active] 1138383012846 catalytic triad [active] 1138383012847 putative dimer interface [polypeptide binding]; other site 1138383012848 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138383012849 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1138383012850 catalytic residue [active] 1138383012851 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1138383012852 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1138383012853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383012854 non-specific DNA binding site [nucleotide binding]; other site 1138383012855 salt bridge; other site 1138383012856 sequence-specific DNA binding site [nucleotide binding]; other site 1138383012857 Predicted membrane protein [Function unknown]; Region: COG2733 1138383012858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383012859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012860 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383012861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012862 S-adenosylmethionine binding site [chemical binding]; other site 1138383012863 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138383012864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383012865 S-adenosylmethionine binding site [chemical binding]; other site 1138383012866 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1138383012867 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138383012868 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138383012869 isocitrate lyase; Provisional; Region: PRK15063 1138383012870 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138383012871 tetramer interface [polypeptide binding]; other site 1138383012872 active site 1138383012873 Mg2+/Mn2+ binding site [ion binding]; other site 1138383012874 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1138383012875 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383012876 active site 2 [active] 1138383012877 active site 1 [active] 1138383012878 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383012879 active site 2 [active] 1138383012880 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138383012881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138383012882 non-specific DNA binding site [nucleotide binding]; other site 1138383012883 salt bridge; other site 1138383012884 sequence-specific DNA binding site [nucleotide binding]; other site 1138383012885 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1138383012886 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138383012887 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138383012888 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138383012889 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383012890 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1138383012891 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1138383012892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383012893 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138383012894 Protein of unknown function (DUF779); Region: DUF779; cl01432 1138383012895 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1138383012896 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383012897 NAD(P) binding site [chemical binding]; other site 1138383012898 catalytic residues [active] 1138383012899 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1138383012900 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383012901 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138383012902 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383012903 substrate binding site [chemical binding]; other site 1138383012904 oxyanion hole (OAH) forming residues; other site 1138383012905 trimer interface [polypeptide binding]; other site 1138383012906 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1138383012907 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1138383012908 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1138383012909 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1138383012910 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138383012911 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138383012912 dimer interface [polypeptide binding]; other site 1138383012913 putative radical transfer pathway; other site 1138383012914 diiron center [ion binding]; other site 1138383012915 tyrosyl radical; other site 1138383012916 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138383012917 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138383012918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383012919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012920 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138383012921 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138383012922 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1138383012923 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138383012924 catalytic residues [active] 1138383012925 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138383012926 DinB superfamily; Region: DinB_2; pfam12867 1138383012927 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1138383012928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383012929 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138383012930 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1138383012931 active site 1138383012932 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383012933 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383012934 PPE family; Region: PPE; pfam00823 1138383012935 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138383012936 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138383012937 classical (c) SDRs; Region: SDR_c; cd05233 1138383012938 NAD(P) binding site [chemical binding]; other site 1138383012939 active site 1138383012940 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138383012941 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138383012942 ring oligomerisation interface [polypeptide binding]; other site 1138383012943 ATP/Mg binding site [chemical binding]; other site 1138383012944 stacking interactions; other site 1138383012945 hinge regions; other site 1138383012946 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138383012947 active site 1138383012948 Cupin domain; Region: Cupin_2; pfam07883 1138383012949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012950 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138383012951 short chain dehydrogenase; Provisional; Region: PRK06197 1138383012952 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138383012953 putative NAD(P) binding site [chemical binding]; other site 1138383012954 active site 1138383012955 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138383012956 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138383012957 dimer interface [polypeptide binding]; other site 1138383012958 putative functional site; other site 1138383012959 putative MPT binding site; other site 1138383012960 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1138383012961 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1138383012962 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1138383012963 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1138383012964 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1138383012965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383012966 Walker A motif; other site 1138383012967 ATP binding site [chemical binding]; other site 1138383012968 Walker B motif; other site 1138383012969 arginine finger; other site 1138383012970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383012971 Walker A motif; other site 1138383012972 ATP binding site [chemical binding]; other site 1138383012973 Walker B motif; other site 1138383012974 arginine finger; other site 1138383012975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383012976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383012977 oxidoreductase; Provisional; Region: PRK06196 1138383012978 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138383012979 putative NAD(P) binding site [chemical binding]; other site 1138383012980 active site 1138383012981 enoyl-CoA hydratase; Provisional; Region: PRK08260 1138383012982 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383012983 substrate binding site [chemical binding]; other site 1138383012984 oxyanion hole (OAH) forming residues; other site 1138383012985 trimer interface [polypeptide binding]; other site 1138383012986 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383012987 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383012988 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1138383012989 carboxylate-amine ligase; Provisional; Region: PRK13517 1138383012990 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1138383012991 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1138383012992 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1138383012993 E-class dimer interface [polypeptide binding]; other site 1138383012994 P-class dimer interface [polypeptide binding]; other site 1138383012995 active site 1138383012996 Cu2+ binding site [ion binding]; other site 1138383012997 Zn2+ binding site [ion binding]; other site 1138383012998 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138383012999 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1138383013000 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1138383013001 active site 1138383013002 catalytic residues [active] 1138383013003 metal binding site [ion binding]; metal-binding site 1138383013004 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1138383013005 putative catalytic site [active] 1138383013006 putative phosphate binding site [ion binding]; other site 1138383013007 active site 1138383013008 metal binding site A [ion binding]; metal-binding site 1138383013009 DNA binding site [nucleotide binding] 1138383013010 putative AP binding site [nucleotide binding]; other site 1138383013011 putative metal binding site B [ion binding]; other site 1138383013012 Heavy-metal-associated domain; Region: HMA; pfam00403 1138383013013 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1138383013014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138383013015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383013016 motif II; other site 1138383013017 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138383013018 PAS fold; Region: PAS_3; pfam08447 1138383013019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1138383013020 putative active site [active] 1138383013021 heme pocket [chemical binding]; other site 1138383013022 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383013023 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1138383013024 ThiC-associated domain; Region: ThiC-associated; pfam13667 1138383013025 ThiC family; Region: ThiC; pfam01964 1138383013026 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1138383013027 dimer interface [polypeptide binding]; other site 1138383013028 substrate binding site [chemical binding]; other site 1138383013029 ATP binding site [chemical binding]; other site 1138383013030 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1138383013031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138383013032 MarR family; Region: MarR; pfam01047 1138383013033 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138383013034 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383013035 Predicted metalloprotease [General function prediction only]; Region: COG2321 1138383013036 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1138383013037 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138383013038 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138383013039 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383013040 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383013041 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138383013042 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138383013043 active site 1138383013044 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383013045 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383013046 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138383013047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138383013048 active site 1138383013049 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138383013050 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138383013051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013052 NAD(P) binding site [chemical binding]; other site 1138383013053 active site 1138383013054 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138383013055 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1138383013056 PA/protease or protease-like domain interface [polypeptide binding]; other site 1138383013057 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1138383013058 Peptidase family M28; Region: Peptidase_M28; pfam04389 1138383013059 active site 1138383013060 metal binding site [ion binding]; metal-binding site 1138383013061 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1138383013062 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138383013063 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1138383013064 PA/protease or protease-like domain interface [polypeptide binding]; other site 1138383013065 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1138383013066 active site 1138383013067 metal binding site [ion binding]; metal-binding site 1138383013068 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1138383013069 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1138383013070 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1138383013071 active site 1138383013072 oxyanion hole [active] 1138383013073 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1138383013074 catalytic triad [active] 1138383013075 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1138383013076 ThiS interaction site; other site 1138383013077 putative active site [active] 1138383013078 tetramer interface [polypeptide binding]; other site 1138383013079 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1138383013080 thiS-thiF/thiG interaction site; other site 1138383013081 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1138383013082 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1138383013083 thiamine phosphate binding site [chemical binding]; other site 1138383013084 active site 1138383013085 pyrophosphate binding site [ion binding]; other site 1138383013086 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1138383013087 nudix motif; other site 1138383013088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138383013089 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1138383013090 substrate binding pocket [chemical binding]; other site 1138383013091 membrane-bound complex binding site; other site 1138383013092 hinge residues; other site 1138383013093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138383013094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138383013095 active site 1138383013096 ATP binding site [chemical binding]; other site 1138383013097 substrate binding site [chemical binding]; other site 1138383013098 activation loop (A-loop); other site 1138383013099 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138383013100 putative active site [active] 1138383013101 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1138383013102 propionate/acetate kinase; Provisional; Region: PRK12379 1138383013103 phosphate acetyltransferase; Reviewed; Region: PRK05632 1138383013104 DRTGG domain; Region: DRTGG; pfam07085 1138383013105 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1138383013106 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1138383013107 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138383013108 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383013109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138383013110 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383013111 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138383013112 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1138383013113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013114 NAD(P) binding site [chemical binding]; other site 1138383013115 active site 1138383013116 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1138383013117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013118 FAD binding site [chemical binding]; other site 1138383013119 substrate binding pocket [chemical binding]; other site 1138383013120 catalytic base [active] 1138383013121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383013123 active site 1138383013124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013126 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138383013127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383013128 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1138383013129 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138383013130 homodimer interface [polypeptide binding]; other site 1138383013131 substrate-cofactor binding pocket; other site 1138383013132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383013133 catalytic residue [active] 1138383013134 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1138383013135 active site residue [active] 1138383013136 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1138383013137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013138 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138383013139 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383013140 CoenzymeA binding site [chemical binding]; other site 1138383013141 subunit interaction site [polypeptide binding]; other site 1138383013142 PHB binding site; other site 1138383013143 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1138383013144 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1138383013145 GDP-binding site [chemical binding]; other site 1138383013146 ACT binding site; other site 1138383013147 IMP binding site; other site 1138383013148 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1138383013149 catalytic core [active] 1138383013150 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1138383013151 Peptidase family M50; Region: Peptidase_M50; pfam02163 1138383013152 active site 1138383013153 putative substrate binding region [chemical binding]; other site 1138383013154 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1138383013155 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1138383013156 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1138383013157 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1138383013158 active site 1138383013159 intersubunit interface [polypeptide binding]; other site 1138383013160 zinc binding site [ion binding]; other site 1138383013161 Na+ binding site [ion binding]; other site 1138383013162 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138383013163 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138383013164 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1138383013165 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138383013166 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1138383013167 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1138383013168 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138383013169 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138383013170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138383013171 active site 1138383013172 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138383013173 classical (c) SDRs; Region: SDR_c; cd05233 1138383013174 NAD(P) binding site [chemical binding]; other site 1138383013175 active site 1138383013176 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383013178 active site 1138383013179 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1138383013180 Clp amino terminal domain; Region: Clp_N; pfam02861 1138383013181 Clp amino terminal domain; Region: Clp_N; pfam02861 1138383013182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383013183 Walker A motif; other site 1138383013184 ATP binding site [chemical binding]; other site 1138383013185 Walker B motif; other site 1138383013186 arginine finger; other site 1138383013187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383013188 Walker A motif; other site 1138383013189 ATP binding site [chemical binding]; other site 1138383013190 Walker B motif; other site 1138383013191 arginine finger; other site 1138383013192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138383013193 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138383013194 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1138383013195 heme-binding site [chemical binding]; other site 1138383013196 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1138383013197 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1138383013198 FAD binding pocket [chemical binding]; other site 1138383013199 FAD binding motif [chemical binding]; other site 1138383013200 phosphate binding motif [ion binding]; other site 1138383013201 beta-alpha-beta structure motif; other site 1138383013202 NAD binding pocket [chemical binding]; other site 1138383013203 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1138383013204 active site 1138383013205 catalytic residues [active] 1138383013206 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1138383013207 DNA binding residues [nucleotide binding] 1138383013208 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138383013209 putative dimer interface [polypeptide binding]; other site 1138383013210 chaperone protein DnaJ; Provisional; Region: PRK14279 1138383013211 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138383013212 HSP70 interaction site [polypeptide binding]; other site 1138383013213 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138383013214 Zn binding sites [ion binding]; other site 1138383013215 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138383013216 dimer interface [polypeptide binding]; other site 1138383013217 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1138383013218 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1138383013219 dimer interface [polypeptide binding]; other site 1138383013220 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1138383013221 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1138383013222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383013223 nucleotide binding site [chemical binding]; other site 1138383013224 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1138383013225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383013226 putative substrate translocation pore; other site 1138383013227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383013228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383013229 nucleotide binding site [chemical binding]; other site 1138383013230 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1138383013231 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1138383013232 4Fe-4S binding domain; Region: Fer4; pfam00037 1138383013233 Cysteine-rich domain; Region: CCG; pfam02754 1138383013234 Cysteine-rich domain; Region: CCG; pfam02754 1138383013235 aminotransferase AlaT; Validated; Region: PRK09265 1138383013236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138383013237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138383013238 homodimer interface [polypeptide binding]; other site 1138383013239 catalytic residue [active] 1138383013240 YibE/F-like protein; Region: YibE_F; pfam07907 1138383013241 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1138383013242 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1138383013243 substrate binding site; other site 1138383013244 tetramer interface; other site 1138383013245 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383013246 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138383013247 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138383013248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383013249 S-adenosylmethionine binding site [chemical binding]; other site 1138383013250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383013251 putative substrate translocation pore; other site 1138383013252 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1138383013253 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1138383013254 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1138383013255 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1138383013256 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138383013257 trimer interface [polypeptide binding]; other site 1138383013258 active site 1138383013259 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138383013260 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383013261 Emopamil binding protein; Region: EBP; pfam05241 1138383013262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138383013263 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138383013264 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138383013265 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383013266 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383013267 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1138383013268 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1138383013269 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1138383013270 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1138383013271 active site 1138383013272 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138383013273 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138383013274 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1138383013275 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1138383013276 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138383013277 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138383013278 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1138383013279 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1138383013280 active site 1138383013281 catalytic residues [active] 1138383013282 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1138383013283 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1138383013284 NAD(P) binding site [chemical binding]; other site 1138383013285 substrate binding site [chemical binding]; other site 1138383013286 dimer interface [polypeptide binding]; other site 1138383013287 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138383013288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138383013289 nucleotide binding site [chemical binding]; other site 1138383013290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013292 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138383013293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1138383013294 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1138383013295 active site 1138383013296 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138383013297 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1138383013298 putative FMN binding site [chemical binding]; other site 1138383013299 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138383013300 Sulfatase; Region: Sulfatase; pfam00884 1138383013301 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1138383013302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383013303 S-adenosylmethionine binding site [chemical binding]; other site 1138383013304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383013305 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383013306 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138383013307 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138383013308 Subtilase family; Region: Peptidase_S8; pfam00082 1138383013309 catalytic residues [active] 1138383013310 catalytic residues [active] 1138383013311 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138383013312 EspG family; Region: ESX-1_EspG; pfam14011 1138383013313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138383013314 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383013315 PPE family; Region: PPE; pfam00823 1138383013316 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138383013317 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383013318 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138383013319 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383013320 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383013321 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138383013322 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138383013323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138383013324 Walker A motif; other site 1138383013325 ATP binding site [chemical binding]; other site 1138383013326 Walker B motif; other site 1138383013327 arginine finger; other site 1138383013328 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383013329 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383013330 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1138383013331 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1138383013332 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1138383013333 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138383013334 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1138383013335 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1138383013336 30S ribosomal protein S18; Provisional; Region: PRK13401 1138383013337 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383013338 PPE family; Region: PPE; pfam00823 1138383013339 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138383013340 Condensation domain; Region: Condensation; pfam00668 1138383013341 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1138383013342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138383013343 Zn binding site [ion binding]; other site 1138383013344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383013347 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383013349 active site 1138383013350 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013351 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138383013352 FAD binding site [chemical binding]; other site 1138383013353 substrate binding site [chemical binding]; other site 1138383013354 catalytic base [active] 1138383013355 acyl-CoA synthetase; Validated; Region: PRK07788 1138383013356 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013357 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013358 active site 1138383013359 CoA binding site [chemical binding]; other site 1138383013360 AMP binding site [chemical binding]; other site 1138383013361 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138383013362 nucleotide binding site [chemical binding]; other site 1138383013363 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138383013364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383013365 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138383013366 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1138383013367 intersubunit interface [polypeptide binding]; other site 1138383013368 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1138383013369 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1138383013370 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1138383013371 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138383013372 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1138383013373 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138383013374 active site 1138383013375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1138383013376 DNA binding site [nucleotide binding] 1138383013377 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138383013378 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138383013379 putative active site [active] 1138383013380 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1138383013381 active site 1138383013382 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1138383013383 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1138383013384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383013385 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1138383013386 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138383013387 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138383013388 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138383013389 putative dimer interface [polypeptide binding]; other site 1138383013390 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138383013391 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1138383013392 tetramer interface [polypeptide binding]; other site 1138383013393 active site 1138383013394 Mg2+/Mn2+ binding site [ion binding]; other site 1138383013395 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1138383013396 L-aspartate oxidase; Provisional; Region: PRK06175 1138383013397 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138383013398 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1138383013399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383013400 catalytic loop [active] 1138383013401 iron binding site [ion binding]; other site 1138383013402 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138383013403 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1138383013404 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1138383013405 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1138383013406 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138383013407 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138383013408 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1138383013409 FAD binding site [chemical binding]; other site 1138383013410 substrate binding site [chemical binding]; other site 1138383013411 catalytic residues [active] 1138383013412 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138383013413 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1138383013414 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138383013415 dimer interface [polypeptide binding]; other site 1138383013416 active site 1138383013417 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1138383013418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013419 NAD(P) binding site [chemical binding]; other site 1138383013420 active site 1138383013421 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383013422 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383013423 active site 2 [active] 1138383013424 active site 1 [active] 1138383013425 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1138383013426 Cl- selectivity filter; other site 1138383013427 Cl- binding residues [ion binding]; other site 1138383013428 pore gating glutamate residue; other site 1138383013429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013431 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138383013432 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1138383013433 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1138383013434 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1138383013435 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1138383013436 Lipase maturation factor; Region: LMF1; pfam06762 1138383013437 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1138383013438 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138383013439 substrate binding pocket [chemical binding]; other site 1138383013440 membrane-bound complex binding site; other site 1138383013441 hinge residues; other site 1138383013442 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383013443 PPE family; Region: PPE; pfam00823 1138383013444 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383013445 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138383013446 PPE family; Region: PPE; pfam00823 1138383013447 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138383013448 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138383013449 formate dehydrogenase; Provisional; Region: PRK07574 1138383013450 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1138383013451 dimerization interface [polypeptide binding]; other site 1138383013452 ligand binding site [chemical binding]; other site 1138383013453 NAD binding site [chemical binding]; other site 1138383013454 catalytic site [active] 1138383013455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383013456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383013457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138383013458 dimerization interface [polypeptide binding]; other site 1138383013459 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1138383013460 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1138383013461 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138383013462 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138383013463 Suppression of tumorigenicity 7; Region: ST7; cd11557 1138383013464 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1138383013465 acetolactate synthase; Reviewed; Region: PRK08322 1138383013466 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138383013467 PYR/PP interface [polypeptide binding]; other site 1138383013468 dimer interface [polypeptide binding]; other site 1138383013469 TPP binding site [chemical binding]; other site 1138383013470 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383013471 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1138383013472 TPP-binding site [chemical binding]; other site 1138383013473 dimer interface [polypeptide binding]; other site 1138383013474 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1138383013475 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1138383013476 NAD(P) binding site [chemical binding]; other site 1138383013477 catalytic residues [active] 1138383013478 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1138383013479 active site 1138383013480 diiron metal binding site [ion binding]; other site 1138383013481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013484 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138383013485 active site 1138383013486 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138383013487 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1138383013488 active site 1138383013489 substrate binding pocket [chemical binding]; other site 1138383013490 homodimer interaction site [polypeptide binding]; other site 1138383013491 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013492 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138383013493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013494 AMP binding site [chemical binding]; other site 1138383013495 active site 1138383013496 acyl-activating enzyme (AAE) consensus motif; other site 1138383013497 acyl-activating enzyme (AAE) consensus motif; other site 1138383013498 CoA binding site [chemical binding]; other site 1138383013499 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1138383013500 O-methyltransferase; Region: Methyltransf_2; pfam00891 1138383013501 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383013502 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1138383013503 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138383013504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138383013505 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138383013506 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138383013507 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1138383013508 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138383013509 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138383013510 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383013511 NAD binding site [chemical binding]; other site 1138383013512 catalytic residues [active] 1138383013513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013515 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138383013516 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013517 acyl-activating enzyme (AAE) consensus motif; other site 1138383013518 AMP binding site [chemical binding]; other site 1138383013519 active site 1138383013520 CoA binding site [chemical binding]; other site 1138383013521 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138383013522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013524 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138383013525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383013526 substrate binding site [chemical binding]; other site 1138383013527 oxyanion hole (OAH) forming residues; other site 1138383013528 trimer interface [polypeptide binding]; other site 1138383013529 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138383013530 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138383013531 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138383013532 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383013533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383013534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138383013535 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138383013536 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138383013537 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383013538 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383013539 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383013540 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383013541 active site 1138383013542 potential frameshift: common BLAST hit: gi|375138704|ref|YP_004999353.1| putative acyl-CoA transferase/carnitine dehydratase 1138383013543 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383013544 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1138383013545 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383013546 active site 2 [active] 1138383013547 active site 1 [active] 1138383013548 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138383013549 active site 2 [active] 1138383013550 active site 1 [active] 1138383013551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013552 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383013553 active site 1138383013554 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1138383013555 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138383013556 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138383013557 substrate binding site [chemical binding]; other site 1138383013558 oxyanion hole (OAH) forming residues; other site 1138383013559 trimer interface [polypeptide binding]; other site 1138383013560 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138383013561 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013562 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383013563 acyl-activating enzyme (AAE) consensus motif; other site 1138383013564 acyl-activating enzyme (AAE) consensus motif; other site 1138383013565 putative AMP binding site [chemical binding]; other site 1138383013566 putative active site [active] 1138383013567 putative CoA binding site [chemical binding]; other site 1138383013568 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138383013569 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1138383013570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138383013571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138383013572 metal binding site [ion binding]; metal-binding site 1138383013573 active site 1138383013574 I-site; other site 1138383013575 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1138383013576 active site 1138383013577 substrate-binding site [chemical binding]; other site 1138383013578 metal-binding site [ion binding] 1138383013579 GTP binding site [chemical binding]; other site 1138383013580 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138383013581 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383013582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383013583 S-adenosylmethionine binding site [chemical binding]; other site 1138383013584 LabA_like proteins; Region: LabA_like; cd06167 1138383013585 putative metal binding site [ion binding]; other site 1138383013586 MMPL family; Region: MMPL; pfam03176 1138383013587 MMPL family; Region: MMPL; pfam03176 1138383013588 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1138383013589 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1138383013590 Predicted integral membrane protein [Function unknown]; Region: COG0392 1138383013591 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138383013592 Protein export membrane protein; Region: SecD_SecF; cl14618 1138383013593 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1138383013594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1138383013595 non-specific DNA binding site [nucleotide binding]; other site 1138383013596 salt bridge; other site 1138383013597 sequence-specific DNA binding site [nucleotide binding]; other site 1138383013598 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1138383013599 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1138383013600 active site 1138383013601 Zn binding site [ion binding]; other site 1138383013602 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138383013603 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383013604 molybdopterin cofactor binding site; other site 1138383013605 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138383013606 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138383013607 putative molybdopterin cofactor binding site; other site 1138383013608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138383013611 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138383013612 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138383013613 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1138383013614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138383013615 putative substrate translocation pore; other site 1138383013616 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1138383013617 putative homodimer interface [polypeptide binding]; other site 1138383013618 putative homotetramer interface [polypeptide binding]; other site 1138383013619 putative allosteric switch controlling residues; other site 1138383013620 putative metal binding site [ion binding]; other site 1138383013621 putative homodimer-homodimer interface [polypeptide binding]; other site 1138383013622 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1138383013623 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1138383013624 SPW repeat; Region: SPW; pfam03779 1138383013625 SPW repeat; Region: SPW; pfam03779 1138383013626 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138383013627 FMN binding site [chemical binding]; other site 1138383013628 substrate binding site [chemical binding]; other site 1138383013629 putative catalytic residue [active] 1138383013630 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138383013631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383013632 S-adenosylmethionine binding site [chemical binding]; other site 1138383013633 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1138383013634 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138383013635 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1138383013636 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1138383013637 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1138383013638 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1138383013639 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138383013640 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383013641 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138383013642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383013643 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138383013644 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383013645 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383013646 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383013647 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138383013648 Pirin-related protein [General function prediction only]; Region: COG1741 1138383013649 Pirin; Region: Pirin; pfam02678 1138383013650 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1138383013651 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1138383013652 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1138383013653 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1138383013654 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138383013655 RDD family; Region: RDD; pfam06271 1138383013656 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383013657 mce related protein; Region: MCE; pfam02470 1138383013658 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383013659 mce related protein; Region: MCE; pfam02470 1138383013660 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383013661 mce related protein; Region: MCE; pfam02470 1138383013662 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383013663 mce related protein; Region: MCE; pfam02470 1138383013664 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383013665 mce related protein; Region: MCE; pfam02470 1138383013666 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138383013667 mce related protein; Region: MCE; pfam02470 1138383013668 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138383013669 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383013670 Permease; Region: Permease; pfam02405 1138383013671 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138383013672 Permease; Region: Permease; pfam02405 1138383013673 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1138383013674 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013675 acyl-activating enzyme (AAE) consensus motif; other site 1138383013676 AMP binding site [chemical binding]; other site 1138383013677 active site 1138383013678 CoA binding site [chemical binding]; other site 1138383013679 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138383013680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383013681 DNA-binding site [nucleotide binding]; DNA binding site 1138383013682 FCD domain; Region: FCD; pfam07729 1138383013683 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138383013684 putative hydrophobic ligand binding site [chemical binding]; other site 1138383013685 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138383013686 active site 1138383013687 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1138383013688 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138383013689 NAD(P) binding site [chemical binding]; other site 1138383013690 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138383013691 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138383013692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383013693 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383013694 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138383013695 classical (c) SDRs; Region: SDR_c; cd05233 1138383013696 NAD(P) binding site [chemical binding]; other site 1138383013697 active site 1138383013698 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138383013699 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138383013700 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138383013701 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383013702 NAD(P) binding site [chemical binding]; other site 1138383013703 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383013704 Cytochrome P450; Region: p450; cl12078 1138383013705 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383013706 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383013707 short chain dehydrogenase; Validated; Region: PRK08264 1138383013708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013709 NAD(P) binding site [chemical binding]; other site 1138383013710 active site 1138383013711 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138383013712 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1138383013713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383013715 active site 1138383013716 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138383013717 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138383013718 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138383013719 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138383013720 active site 1138383013721 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138383013722 catalytic triad [active] 1138383013723 dimer interface [polypeptide binding]; other site 1138383013724 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1138383013725 Strictosidine synthase; Region: Str_synth; pfam03088 1138383013726 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138383013727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013729 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138383013730 FAD binding domain; Region: FAD_binding_4; pfam01565 1138383013731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013732 NAD(P) binding site [chemical binding]; other site 1138383013733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383013734 active site 1138383013735 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138383013736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138383013737 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138383013738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013740 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1138383013741 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1138383013742 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1138383013743 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138383013744 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1138383013745 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138383013746 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1138383013747 ligand binding site [chemical binding]; other site 1138383013748 homodimer interface [polypeptide binding]; other site 1138383013749 NAD(P) binding site [chemical binding]; other site 1138383013750 trimer interface B [polypeptide binding]; other site 1138383013751 trimer interface A [polypeptide binding]; other site 1138383013752 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1138383013753 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383013754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383013755 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1138383013756 FAD binding site [chemical binding]; other site 1138383013757 substrate binding site [chemical binding]; other site 1138383013758 catalytic base [active] 1138383013759 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1138383013760 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1138383013761 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1138383013762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138383013763 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138383013764 NAD binding site [chemical binding]; other site 1138383013765 homodimer interface [polypeptide binding]; other site 1138383013766 active site 1138383013767 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1138383013768 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1138383013769 NAD(P) binding site [chemical binding]; other site 1138383013770 catalytic residues [active] 1138383013771 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138383013772 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138383013773 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383013774 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383013775 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383013776 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138383013777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013779 Pirin-related protein [General function prediction only]; Region: COG1741 1138383013780 Pirin; Region: Pirin; pfam02678 1138383013781 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1138383013782 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1138383013783 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1138383013784 dimerization interface [polypeptide binding]; other site 1138383013785 DPS ferroxidase diiron center [ion binding]; other site 1138383013786 ion pore; other site 1138383013787 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138383013788 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138383013789 minor groove reading motif; other site 1138383013790 helix-hairpin-helix signature motif; other site 1138383013791 active site 1138383013792 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1138383013793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138383013794 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138383013795 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138383013796 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138383013797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013798 NAD(P) binding site [chemical binding]; other site 1138383013799 active site 1138383013800 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383013801 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1138383013802 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138383013803 Cytochrome P450; Region: p450; cl12078 1138383013804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013806 TOBE domain; Region: TOBE; cl01440 1138383013807 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383013808 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138383013809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383013810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013811 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383013812 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138383013813 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383013814 hydrophobic ligand binding site; other site 1138383013815 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138383013816 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138383013817 putative di-iron ligands [ion binding]; other site 1138383013818 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138383013819 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138383013820 FAD binding pocket [chemical binding]; other site 1138383013821 FAD binding motif [chemical binding]; other site 1138383013822 phosphate binding motif [ion binding]; other site 1138383013823 beta-alpha-beta structure motif; other site 1138383013824 NAD binding pocket [chemical binding]; other site 1138383013825 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138383013826 catalytic loop [active] 1138383013827 iron binding site [ion binding]; other site 1138383013828 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1138383013829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383013830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1138383013831 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1138383013832 Coenzyme A binding pocket [chemical binding]; other site 1138383013833 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138383013834 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138383013835 Hemerythrin-like domain; Region: Hr-like; cd12108 1138383013836 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1138383013837 dimanganese center [ion binding]; other site 1138383013838 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138383013839 GAF domain; Region: GAF; pfam01590 1138383013840 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138383013841 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138383013842 putative active site [active] 1138383013843 putative catalytic site [active] 1138383013844 Domain of unknown function DUF302; Region: DUF302; pfam03625 1138383013845 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1138383013846 active site 1138383013847 metal binding site [ion binding]; metal-binding site 1138383013848 homotetramer interface [polypeptide binding]; other site 1138383013849 MarR family; Region: MarR_2; pfam12802 1138383013850 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138383013851 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265 1138383013852 Walker A/P-loop; other site 1138383013853 ATP binding site [chemical binding]; other site 1138383013854 Q-loop/lid; other site 1138383013855 ABC transporter signature motif; other site 1138383013856 Walker B; other site 1138383013857 D-loop; other site 1138383013858 H-loop/switch region; other site 1138383013859 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138383013860 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138383013861 Predicted esterase [General function prediction only]; Region: COG0627 1138383013862 Predicted membrane protein [Function unknown]; Region: COG3619 1138383013863 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1138383013864 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1138383013865 trehalose synthase; Region: treS_nterm; TIGR02456 1138383013866 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1138383013867 active site 1138383013868 catalytic site [active] 1138383013869 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138383013870 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138383013871 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1138383013872 protein binding site [polypeptide binding]; other site 1138383013873 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1138383013874 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1138383013875 elongation factor G; Reviewed; Region: PRK12740 1138383013876 G1 box; other site 1138383013877 putative GEF interaction site [polypeptide binding]; other site 1138383013878 GTP/Mg2+ binding site [chemical binding]; other site 1138383013879 Switch I region; other site 1138383013880 G2 box; other site 1138383013881 G3 box; other site 1138383013882 Switch II region; other site 1138383013883 G4 box; other site 1138383013884 G5 box; other site 1138383013885 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138383013886 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138383013887 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138383013888 acyl-CoA synthetase; Validated; Region: PRK05852 1138383013889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013890 acyl-activating enzyme (AAE) consensus motif; other site 1138383013891 AMP binding site [chemical binding]; other site 1138383013892 active site 1138383013893 CoA binding site [chemical binding]; other site 1138383013894 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1138383013895 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138383013896 PYR/PP interface [polypeptide binding]; other site 1138383013897 dimer interface [polypeptide binding]; other site 1138383013898 TPP binding site [chemical binding]; other site 1138383013899 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383013900 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138383013901 TPP-binding site; other site 1138383013902 dimer interface [polypeptide binding]; other site 1138383013903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383013904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383013905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138383013906 dimerization interface [polypeptide binding]; other site 1138383013907 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138383013908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138383013909 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138383013910 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138383013911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013912 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013913 acyl-activating enzyme (AAE) consensus motif; other site 1138383013914 acyl-activating enzyme (AAE) consensus motif; other site 1138383013915 AMP binding site [chemical binding]; other site 1138383013916 active site 1138383013917 CoA binding site [chemical binding]; other site 1138383013918 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138383013919 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138383013920 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138383013921 putative NAD(P) binding site [chemical binding]; other site 1138383013922 active site 1138383013923 putative substrate binding site [chemical binding]; other site 1138383013924 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138383013925 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138383013926 putative NAD(P) binding site [chemical binding]; other site 1138383013927 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138383013928 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138383013929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383013930 S-adenosylmethionine binding site [chemical binding]; other site 1138383013931 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383013932 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138383013933 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138383013934 active site 1138383013935 catalytic triad [active] 1138383013936 oxyanion hole [active] 1138383013937 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1138383013938 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138383013939 NAD binding site [chemical binding]; other site 1138383013940 catalytic residues [active] 1138383013941 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1138383013942 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138383013943 PYR/PP interface [polypeptide binding]; other site 1138383013944 dimer interface [polypeptide binding]; other site 1138383013945 TPP binding site [chemical binding]; other site 1138383013946 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138383013947 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138383013948 TPP-binding site; other site 1138383013949 dimer interface [polypeptide binding]; other site 1138383013950 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383013951 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383013952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383013953 NAD(P) binding site [chemical binding]; other site 1138383013954 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138383013955 active site 1138383013956 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383013957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383013958 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383013959 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383013960 [2Fe-2S] cluster binding site [ion binding]; other site 1138383013961 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1138383013962 putative alpha subunit interface [polypeptide binding]; other site 1138383013963 putative active site [active] 1138383013964 putative substrate binding site [chemical binding]; other site 1138383013965 Fe binding site [ion binding]; other site 1138383013966 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138383013967 classical (c) SDRs; Region: SDR_c; cd05233 1138383013968 NAD(P) binding site [chemical binding]; other site 1138383013969 active site 1138383013970 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1138383013971 Strictosidine synthase; Region: Str_synth; pfam03088 1138383013972 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138383013973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138383013974 DNA-binding site [nucleotide binding]; DNA binding site 1138383013975 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1138383013976 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1138383013977 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138383013978 acyl-activating enzyme (AAE) consensus motif; other site 1138383013979 putative AMP binding site [chemical binding]; other site 1138383013980 putative active site [active] 1138383013981 putative CoA binding site [chemical binding]; other site 1138383013982 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1138383013983 classical (c) SDRs; Region: SDR_c; cd05233 1138383013984 NAD(P) binding site [chemical binding]; other site 1138383013985 active site 1138383013986 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138383013987 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383013988 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138383013989 acyl-activating enzyme (AAE) consensus motif; other site 1138383013990 acyl-activating enzyme (AAE) consensus motif; other site 1138383013991 putative AMP binding site [chemical binding]; other site 1138383013992 putative active site [active] 1138383013993 putative CoA binding site [chemical binding]; other site 1138383013994 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138383013995 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138383013996 NAD binding site [chemical binding]; other site 1138383013997 catalytic Zn binding site [ion binding]; other site 1138383013998 substrate binding site [chemical binding]; other site 1138383013999 structural Zn binding site [ion binding]; other site 1138383014000 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138383014001 hydrophobic ligand binding site; other site 1138383014002 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138383014003 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1138383014004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383014005 NAD(P) binding site [chemical binding]; other site 1138383014006 active site 1138383014007 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138383014008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383014009 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383014010 DNA binding residues [nucleotide binding] 1138383014011 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138383014012 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138383014013 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1138383014014 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1138383014015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138383014016 motif II; other site 1138383014017 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138383014018 acyl-CoA synthetase; Provisional; Region: PRK13383 1138383014019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383014020 AMP binding site [chemical binding]; other site 1138383014021 active site 1138383014022 acyl-activating enzyme (AAE) consensus motif; other site 1138383014023 CoA binding site [chemical binding]; other site 1138383014024 short chain dehydrogenase; Provisional; Region: PRK07825 1138383014025 classical (c) SDRs; Region: SDR_c; cd05233 1138383014026 NAD(P) binding site [chemical binding]; other site 1138383014027 active site 1138383014028 Cutinase; Region: Cutinase; pfam01083 1138383014029 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1138383014030 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1138383014031 putative NAD(P) binding site [chemical binding]; other site 1138383014032 active site 1138383014033 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138383014034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383014035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383014036 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383014037 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138383014038 cyclase homology domain; Region: CHD; cd07302 1138383014039 nucleotidyl binding site; other site 1138383014040 metal binding site [ion binding]; metal-binding site 1138383014041 dimer interface [polypeptide binding]; other site 1138383014042 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383014043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383014044 S-adenosylmethionine binding site [chemical binding]; other site 1138383014045 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138383014046 hydrophobic ligand binding site; other site 1138383014047 short chain dehydrogenase; Validated; Region: PRK08264 1138383014048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383014049 NAD(P) binding site [chemical binding]; other site 1138383014050 active site 1138383014051 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1138383014052 CGNR zinc finger; Region: zf-CGNR; pfam11706 1138383014053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138383014054 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138383014055 S-adenosylmethionine binding site [chemical binding]; other site 1138383014056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383014057 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138383014058 NAD(P) binding site [chemical binding]; other site 1138383014059 active site 1138383014060 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138383014061 CoenzymeA binding site [chemical binding]; other site 1138383014062 subunit interaction site [polypeptide binding]; other site 1138383014063 PHB binding site; other site 1138383014064 Predicted membrane protein [Function unknown]; Region: COG3305 1138383014065 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1138383014066 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1138383014067 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138383014068 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138383014069 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1138383014070 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138383014071 putative NAD(P) binding site [chemical binding]; other site 1138383014072 catalytic Zn binding site [ion binding]; other site 1138383014073 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138383014074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383014075 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138383014076 NAD(P) binding site [chemical binding]; other site 1138383014077 active site 1138383014078 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1138383014079 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1138383014080 short chain dehydrogenase; Provisional; Region: PRK06940 1138383014081 classical (c) SDRs; Region: SDR_c; cd05233 1138383014082 NAD(P) binding site [chemical binding]; other site 1138383014083 active site 1138383014084 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138383014085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138383014086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383014087 Protein of unknown function, DUF417; Region: DUF417; cl01162 1138383014088 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138383014089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383014090 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138383014091 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138383014092 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1138383014093 putative hydrophobic ligand binding site [chemical binding]; other site 1138383014094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138383014095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138383014096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1138383014097 dimerization interface [polypeptide binding]; other site 1138383014098 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138383014099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138383014100 NAD(P) binding site [chemical binding]; other site 1138383014101 active site 1138383014102 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1138383014103 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138383014104 classical (c) SDRs; Region: SDR_c; cd05233 1138383014105 NAD(P) binding site [chemical binding]; other site 1138383014106 active site 1138383014107 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138383014108 classical (c) SDRs; Region: SDR_c; cd05233 1138383014109 NAD(P) binding site [chemical binding]; other site 1138383014110 active site 1138383014111 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138383014112 metal-binding site [ion binding] 1138383014113 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138383014114 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138383014115 metal-binding site [ion binding] 1138383014116 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138383014117 Predicted esterase [General function prediction only]; Region: COG0627 1138383014118 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1138383014119 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1138383014120 NodB motif; other site 1138383014121 active site 1138383014122 catalytic site [active] 1138383014123 metal binding site [ion binding]; metal-binding site 1138383014124 Secretory lipase; Region: LIP; pfam03583 1138383014125 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138383014126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138383014127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383014128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383014129 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138383014130 classical (c) SDRs; Region: SDR_c; cd05233 1138383014131 NAD(P) binding site [chemical binding]; other site 1138383014132 active site 1138383014133 acyl-CoA synthetase; Provisional; Region: PRK13388 1138383014134 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138383014135 acyl-activating enzyme (AAE) consensus motif; other site 1138383014136 AMP binding site [chemical binding]; other site 1138383014137 active site 1138383014138 CoA binding site [chemical binding]; other site 1138383014139 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383014140 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383014141 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383014142 active site 1138383014143 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383014144 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383014145 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138383014146 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138383014147 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138383014148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1138383014149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1138383014150 DNA binding site [nucleotide binding] 1138383014151 domain linker motif; other site 1138383014152 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1138383014153 dimerization interface [polypeptide binding]; other site 1138383014154 ligand binding site [chemical binding]; other site 1138383014155 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138383014156 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138383014157 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1138383014158 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138383014159 active site 1138383014160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383014161 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138383014162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383014163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138383014164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138383014165 active site 1138383014166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383014167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383014168 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138383014169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383014170 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1138383014171 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1138383014172 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138383014173 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138383014174 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1138383014175 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 1138383014176 putative active site [active] 1138383014177 catalytic residue [active] 1138383014178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138383014179 anti sigma factor interaction site; other site 1138383014180 regulatory phosphorylation site [posttranslational modification]; other site 1138383014181 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138383014182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138383014183 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138383014184 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383014185 putative active site [active] 1138383014186 ATP binding site [chemical binding]; other site 1138383014187 putative substrate binding site [chemical binding]; other site 1138383014188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138383014189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138383014190 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1138383014191 Phosphotransferase enzyme family; Region: APH; pfam01636 1138383014192 Ecdysteroid kinase; Region: EcKinase; cl17738 1138383014193 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138383014194 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1138383014195 active site 1138383014196 putative substrate binding pocket [chemical binding]; other site 1138383014197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138383014198 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138383014199 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138383014200 [2Fe-2S] cluster binding site [ion binding]; other site 1138383014201 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1138383014202 putative alpha subunit interface [polypeptide binding]; other site 1138383014203 putative active site [active] 1138383014204 putative substrate binding site [chemical binding]; other site 1138383014205 Fe binding site [ion binding]; other site 1138383014206 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138383014207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138383014208 active site 1138383014209 phosphorylation site [posttranslational modification] 1138383014210 intermolecular recognition site; other site 1138383014211 dimerization interface [polypeptide binding]; other site 1138383014212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138383014213 DNA binding residues [nucleotide binding] 1138383014214 dimerization interface [polypeptide binding]; other site 1138383014215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138383014216 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138383014217 Transport protein; Region: actII; TIGR00833 1138383014218 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138383014219 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383014220 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138383014221 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383014222 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138383014223 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138383014224 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1138383014225 catalytic residue [active] 1138383014226 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1138383014227 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138383014228 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1138383014229 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1138383014230 active site 1138383014231 NTP binding site [chemical binding]; other site 1138383014232 metal binding triad [ion binding]; metal-binding site 1138383014233 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1138383014234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138383014235 Zn2+ binding site [ion binding]; other site 1138383014236 Mg2+ binding site [ion binding]; other site 1138383014237 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1138383014238 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138383014239 active site 1138383014240 Ap6A binding site [chemical binding]; other site 1138383014241 nudix motif; other site 1138383014242 metal binding site [ion binding]; metal-binding site 1138383014243 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1138383014244 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1138383014245 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1138383014246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138383014247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138383014248 DNA binding residues [nucleotide binding] 1138383014249 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138383014250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138383014251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138383014252 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138383014253 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1138383014254 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138383014255 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138383014256 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138383014257 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138383014258 active site 1138383014259 metal binding site [ion binding]; metal-binding site 1138383014260 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1138383014261 ParB-like nuclease domain; Region: ParBc; pfam02195 1138383014262 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138383014263 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138383014264 P-loop; other site 1138383014265 Magnesium ion binding site [ion binding]; other site 1138383014266 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138383014267 Magnesium ion binding site [ion binding]; other site 1138383014268 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138383014269 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1138383014270 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1138383014271 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1138383014272 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1138383014273 G-X-X-G motif; other site 1138383014274 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1138383014275 RxxxH motif; other site 1138383014276 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1138383014277 Ribonuclease P; Region: Ribonuclease_P; cl00457