-- dump date 20140619_152918 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 561304000001 SEQ_END SEQ_END NC_011896.1 3268071 3268071 DR NC_011896.1; contig end 3268071..3268071 Mycobacterium leprae Br4923 YP_002502760.1 CDS dnaA NC_011896.1 1 1566 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1566 Mycobacterium leprae Br4923 7327331 YP_002502761.1 CDS dnaN NC_011896.1 2081 3280 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2081..3280 Mycobacterium leprae Br4923 7326174 YP_002502762.1 CDS recF NC_011896.1 3281 4438 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3281..4438 Mycobacterium leprae Br4923 7326182 YP_002502763.1 CDS MLBr_00004 NC_011896.1 4435 5004 D hypothetical protein 4435..5004 Mycobacterium leprae Br4923 7326610 YP_002502764.1 CDS gyrB NC_011896.1 5229 7265 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 5229..7265 Mycobacterium leprae Br4923 7327009 YP_002502765.1 CDS gyrA NC_011896.1 7318 11067 D DNA gyrase subunit A 7318..11067 Mycobacterium leprae Br4923 7324668 YP_002502766.1 CDS MLBr_00007 NC_011896.1 11195 12106 D hypothetical protein 11195..12106 Mycobacterium leprae Br4923 7324667 YP_002502767.1 CDS MLBr_00008 NC_011896.1 12856 13230 R hypothetical protein complement(12856..13230) Mycobacterium leprae Br4923 7327199 YP_002502768.1 CDS MLBr_00009 NC_011896.1 13775 13966 D hypothetical protein 13775..13966 Mycobacterium leprae Br4923 7327011 YP_002502769.1 CDS ppiA NC_011896.1 15989 16537 D peptidyl-prolyl cis-trans isomerase 15989..16537 Mycobacterium leprae Br4923 7327013 YP_002502770.1 CDS MLBr_00012 NC_011896.1 16562 16975 R hypothetical protein complement(16562..16975) Mycobacterium leprae Br4923 7325000 YP_002502771.1 CDS MLBr_00013 NC_011896.1 17130 17411 R integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein complement(17130..17411) Mycobacterium leprae Br4923 7327014 YP_002502772.1 CDS pabA NC_011896.1 18321 19019 D aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 18321..19019 Mycobacterium leprae Br4923 7327016 YP_002502773.1 CDS pknB NC_011896.1 18997 20865 R serine/threonine protein kinase complement(18997..20865) Mycobacterium leprae Br4923 7327345 YP_002502774.1 CDS pknA NC_011896.1 20875 22188 R serine/threonine protein kinase complement(20875..22188) Mycobacterium leprae Br4923 7327403 YP_002502775.1 CDS pbpA NC_011896.1 22185 23663 R penicillin-binding protein complement(22185..23663) Mycobacterium leprae Br4923 7327402 YP_002502776.1 CDS rodA NC_011896.1 23660 25057 R cell-division protein complement(23660..25057) Mycobacterium leprae Br4923 7327354 YP_002502777.1 CDS MLBr_00020 NC_011896.1 25054 26583 R hypothetical protein complement(25054..26583) Mycobacterium leprae Br4923 7326638 YP_002502778.1 CDS MLBr_00021 NC_011896.1 26580 27047 R hypothetical protein complement(26580..27047) Mycobacterium leprae Br4923 7327017 YP_002502779.1 CDS MLBr_00022 NC_011896.1 27169 28635 R hypothetical protein complement(27169..28635) Mycobacterium leprae Br4923 7327018 YP_002502780.1 CDS MLBr_00023 NC_011896.1 28950 29261 R hypothetical protein complement(28950..29261) Mycobacterium leprae Br4923 7325378 YP_002502781.1 CDS MLBr_00024 NC_011896.1 29771 30022 D hypothetical protein 29771..30022 Mycobacterium leprae Br4923 7327020 YP_002502782.1 CDS MLBr_00025 NC_011896.1 30289 30579 R hypothetical protein complement(30289..30579) Mycobacterium leprae Br4923 7327021 YP_002502783.1 CDS MLBr_00028 NC_011896.1 33096 33701 D hypothetical protein 33096..33701 Mycobacterium leprae Br4923 7327023 YP_002502784.1 CDS MLBr_00029 NC_011896.1 34029 34634 R hypothetical protein complement(34029..34634) Mycobacterium leprae Br4923 7327024 YP_002502785.1 CDS MLBr_00030 NC_011896.1 34746 35087 R hypothetical protein complement(34746..35087) Mycobacterium leprae Br4923 7327025 YP_002502786.1 CDS MLBr_00031 NC_011896.1 35283 36119 R hypothetical protein complement(35283..36119) Mycobacterium leprae Br4923 7327026 YP_002502787.1 CDS leuS NC_011896.1 36317 39235 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 36317..39235 Mycobacterium leprae Br4923 7327027 YP_002502788.1 CDS MLBr_00041 NC_011896.1 50652 51992 D protease 50652..51992 Mycobacterium leprae Br4923 7325787 YP_002502789.1 CDS MLBr_00042 NC_011896.1 51989 53392 D hypothetical protein 51989..53392 Mycobacterium leprae Br4923 7325788 YP_002502790.1 CDS MLBr_00044 NC_011896.1 54694 55035 D hypothetical protein 54694..55035 Mycobacterium leprae Br4923 7325790 YP_002502791.1 CDS MLBr_00047 NC_011896.1 58016 59554 R hypothetical protein complement(58016..59554) Mycobacterium leprae Br4923 7325793 YP_002502792.1 CDS MLBr_00048 NC_011896.1 59551 61311 R hypothetical protein complement(59551..61311) Mycobacterium leprae Br4923 7325794 YP_002502793.1 CDS MLBr_00049 NC_011896.1 61402 61689 R hypothetical protein complement(61402..61689) Mycobacterium leprae Br4923 7325795 YP_002502794.1 CDS MLBr_00050 NC_011896.1 61716 62018 R hypothetical protein complement(61716..62018) Mycobacterium leprae Br4923 7325796 YP_002502795.1 CDS MLBr_00051 NC_011896.1 62197 63105 R PPE family protein complement(62197..63105) Mycobacterium leprae Br4923 7325797 YP_002502796.1 CDS MLBr_00052 NC_011896.1 63315 65108 R hypothetical protein complement(63315..65108) Mycobacterium leprae Br4923 7325798 YP_002502797.1 CDS MLBr_00053 NC_011896.1 65182 67416 R hypothetical protein complement(65182..67416) Mycobacterium leprae Br4923 7325799 YP_002502798.1 CDS MLBr_00054 NC_011896.1 67413 68858 R hypothetical protein complement(67413..68858) Mycobacterium leprae Br4923 7325800 YP_002502799.1 CDS MLBr_00055 NC_011896.1 68862 70583 R hypothetical protein complement(68862..70583) Mycobacterium leprae Br4923 7325801 YP_002502800.1 CDS MLBr_00056 NC_011896.1 70580 71089 R hypothetical protein complement(70580..71089) Mycobacterium leprae Br4923 7325802 YP_002502801.1 CDS gltB NC_011896.1 77736 82319 D ferredoxin-dependent glutamate synthase 77736..82319 Mycobacterium leprae Br4923 7325807 YP_002502802.1 CDS gltD NC_011896.1 82312 83778 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 82312..83778 Mycobacterium leprae Br4923 7325366 YP_002502803.1 CDS MLBr_00064 NC_011896.1 85995 86639 R transcriptional regulator complement(85995..86639) Mycobacterium leprae Br4923 7325808 YP_002502804.1 CDS MLBr_00065 NC_011896.1 86708 88192 D monooxygenase 86708..88192 Mycobacterium leprae Br4923 7325809 YP_002502805.1 CDS menG NC_011896.1 88273 88746 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(88273..88746) Mycobacterium leprae Br4923 7325810 YP_002502806.1 CDS hns NC_011896.1 88768 89133 R histone-like protein complement(88768..89133) Mycobacterium leprae Br4923 7325450 YP_002502807.1 CDS MLBr_00068 NC_011896.1 89647 90363 R hypothetical protein complement(89647..90363) Mycobacterium leprae Br4923 7324690 YP_002502808.1 CDS MLBr_00069 NC_011896.1 90548 90946 R hypothetical protein complement(90548..90946) Mycobacterium leprae Br4923 7325811 YP_002502809.1 CDS MLBr_00070 NC_011896.1 91323 91586 R hypothetical protein complement(91323..91586) Mycobacterium leprae Br4923 7325812 YP_002502810.1 CDS MLBr_00071 NC_011896.1 91940 92473 R hypothetical protein complement(91940..92473) Mycobacterium leprae Br4923 7325813 YP_002502811.1 CDS sodA NC_011896.1 92674 93297 R superoxide dismutase complement(92674..93297) Mycobacterium leprae Br4923 7325814 YP_002502812.1 CDS MLBr_00073 NC_011896.1 94119 95153 D hypothetical protein 94119..95153 Mycobacterium leprae Br4923 7325997 YP_002502813.1 CDS glpQ NC_011896.1 95159 95974 D glycerophosphoryl diester phosphodiesterase 95159..95974 Mycobacterium leprae Br4923 7325815 YP_002502814.1 CDS pheA NC_011896.1 98452 99420 D catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 98452..99420 Mycobacterium leprae Br4923 7325817 YP_002502815.1 CDS MLBr_00079 NC_011896.1 99417 100112 D phosphoglycerate mutase 99417..100112 Mycobacterium leprae Br4923 7327388 YP_002502816.1 CDS MLBr_00081 NC_011896.1 100675 102027 R hypothetical protein complement(100675..102027) Mycobacterium leprae Br4923 7325819 YP_002502817.1 CDS serS NC_011896.1 102149 103402 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 102149..103402 Mycobacterium leprae Br4923 7325820 YP_002502818.1 CDS MLBr_00087 NC_011896.1 109076 109849 D acyltransferase 109076..109849 Mycobacterium leprae Br4923 7325824 YP_002502819.1 CDS MLBr_00089 NC_011896.1 110356 111201 D hypothetical protein 110356..111201 Mycobacterium leprae Br4923 7325826 YP_002502820.1 CDS MLBr_00091 NC_011896.1 113180 113890 R hypothetical protein complement(113180..113890) Mycobacterium leprae Br4923 7326129 YP_002502821.1 CDS glf NC_011896.1 114157 115398 D UDP-galactopyranose mutase 114157..115398 Mycobacterium leprae Br4923 7325828 YP_002502822.1 CDS MLBr_00093 NC_011896.1 115398 117329 D hypothetical protein 115398..117329 Mycobacterium leprae Br4923 7325343 YP_002502823.1 CDS MLBr_00094 NC_011896.1 117322 117900 D hypothetical protein 117322..117900 Mycobacterium leprae Br4923 7325829 YP_002502824.1 CDS MLBr_00095 NC_011896.1 117897 118805 D catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 117897..118805 Mycobacterium leprae Br4923 7325830 YP_002502825.1 CDS MLBr_00096 NC_011896.1 118846 120795 D hypothetical protein 118846..120795 Mycobacterium leprae Br4923 7325831 YP_002502826.1 CDS fbpA NC_011896.1 121184 122176 D antigen 85A, mycolytransferase 121184..122176 Mycobacterium leprae Br4923 7325832 YP_002502827.1 CDS fbpC NC_011896.1 122337 123242 D antigen 85C, mycolyltransferase 122337..123242 Mycobacterium leprae Br4923 7325288 YP_002502828.1 CDS MLBr_00099 NC_011896.1 123397 124407 D hypothetical protein 123397..124407 Mycobacterium leprae Br4923 7325290 YP_002502829.1 CDS fadD32 NC_011896.1 124626 126533 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 124626..126533 Mycobacterium leprae Br4923 7325833 YP_002502830.1 CDS pks13 NC_011896.1 126545 131899 D polyketide synthase 126545..131899 Mycobacterium leprae Br4923 7325255 YP_002502831.1 CDS accD4 NC_011896.1 131896 133449 D acyl CoA carboxylase beta subunit 131896..133449 Mycobacterium leprae Br4923 7327412 YP_002502832.1 CDS embB NC_011896.1 136600 139851 R arabinosyltransferase complement(136600..139851) Mycobacterium leprae Br4923 7325277 YP_002502833.1 CDS embA NC_011896.1 139848 143183 R arabinosyltransferase complement(139848..143183) Mycobacterium leprae Br4923 7325225 YP_002502834.1 CDS embC NC_011896.1 144142 147354 R arabinosyltransferase complement(144142..147354) Mycobacterium leprae Br4923 7325224 YP_002502835.1 CDS MLBr_00107 NC_011896.1 147487 149385 R hypothetical protein complement(147487..149385) Mycobacterium leprae Br4923 7325226 YP_002502836.1 CDS MLBr_00108 NC_011896.1 149388 150152 R short chain dehydrogenase complement(149388..150152) Mycobacterium leprae Br4923 7325834 YP_002502837.1 CDS MLBr_00109 NC_011896.1 150155 151537 R FAD-linked oxidoreductase complement(150155..151537) Mycobacterium leprae Br4923 7325835 YP_002502838.1 CDS MLBr_00110 NC_011896.1 151605 151976 R hypothetical protein complement(151605..151976) Mycobacterium leprae Br4923 7325836 YP_002502839.1 CDS MLBr_00112 NC_011896.1 152810 153640 R ABC transporter complement(152810..153640) Mycobacterium leprae Br4923 7325838 YP_002502840.1 CDS rfbE NC_011896.1 153690 154541 R glycosyl transferase family protein complement(153690..154541) Mycobacterium leprae Br4923 7325839 YP_002502841.1 CDS MLBr_00114 NC_011896.1 154603 155421 R ABC transporter ATP-binding protein complement(154603..155421) Mycobacterium leprae Br4923 7326617 YP_002502842.1 CDS MLBr_00115 NC_011896.1 155440 155964 R hypothetical protein complement(155440..155964) Mycobacterium leprae Br4923 7325840 YP_002502843.1 CDS MLBr_00116 NC_011896.1 155992 157956 R hypothetical protein complement(155992..157956) Mycobacterium leprae Br4923 7325841 YP_002502844.1 CDS MLBr_00117 NC_011896.1 158083 159279 D hypothetical protein 158083..159279 Mycobacterium leprae Br4923 7325842 YP_002502845.1 CDS MLBr_00118 NC_011896.1 159276 160286 R oxidireductase complement(159276..160286) Mycobacterium leprae Br4923 7325843 YP_002502846.1 CDS lipE NC_011896.1 160522 161757 R hydrolase complement(160522..161757) Mycobacterium leprae Br4923 7325983 YP_002502847.1 CDS echA1 NC_011896.1 161768 162604 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(161768..162604) Mycobacterium leprae Br4923 7325390 YP_002502848.1 CDS MLBr_00121 NC_011896.1 163797 164066 R hypothetical protein complement(163797..164066) Mycobacterium leprae Br4923 7326190 YP_002502849.1 CDS MLBr_00124 NC_011896.1 166976 167416 R hypothetical protein complement(166976..167416) Mycobacterium leprae Br4923 7325846 YP_002502850.1 CDS MLBr_00125 NC_011896.1 167625 168941 D glycosyl transferase family protein 167625..168941 Mycobacterium leprae Br4923 7325847 YP_002502851.1 CDS MLBr_00126 NC_011896.1 169612 170433 D hypothetical protein 169612..170433 Mycobacterium leprae Br4923 7325848 YP_002502852.1 CDS MLBr_00127 NC_011896.1 170689 171378 D hypothetical protein 170689..171378 Mycobacterium leprae Br4923 7325849 YP_002502853.1 CDS MLBr_00128 NC_011896.1 171643 172950 D glycosyl transferase family protein 171643..172950 Mycobacterium leprae Br4923 7325850 YP_002502854.1 CDS MLBr_00129 NC_011896.1 173197 174453 R hypothetical protein complement(173197..174453) Mycobacterium leprae Br4923 7325851 YP_002502855.1 CDS MLBr_00130 NC_011896.1 174493 175305 R hypothetical protein complement(174493..175305) Mycobacterium leprae Br4923 7325852 YP_002502856.1 CDS MLBr_00131 NC_011896.1 175468 176616 D oxidoreductase 175468..176616 Mycobacterium leprae Br4923 7325853 YP_002502857.1 CDS fadD29 NC_011896.1 177197 179239 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 177197..179239 Mycobacterium leprae Br4923 7325854 YP_002502858.1 CDS MLBr_00133 NC_011896.1 179283 179915 D hypothetical protein 179283..179915 Mycobacterium leprae Br4923 7325252 YP_002502859.1 CDS fadD22 NC_011896.1 180054 182177 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 180054..182177 Mycobacterium leprae Br4923 7325855 YP_002502860.1 CDS MLBr_00135 NC_011896.1 182200 188511 D polyketide synthase 182200..188511 Mycobacterium leprae Br4923 7325248 YP_002502861.1 CDS lppX NC_011896.1 188578 189279 D lipoprotein 188578..189279 Mycobacterium leprae Br4923 7325856 YP_002502862.1 CDS mmpL7 NC_011896.1 189280 191988 R hypothetical protein complement(189280..191988) Mycobacterium leprae Br4923 7325413 YP_002502863.1 CDS fadD28 NC_011896.1 192040 193779 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(192040..193779) Mycobacterium leprae Br4923 7324907 YP_002502864.1 CDS mas NC_011896.1 194248 200598 D mycocerosic synthase 194248..200598 Mycobacterium leprae Br4923 7325251 YP_002502865.1 CDS MLBr_00141 NC_011896.1 202334 202588 R hypothetical protein complement(202334..202588) Mycobacterium leprae Br4923 7325857 YP_002502866.1 CDS MLBr_00142 NC_011896.1 204390 204638 D hypothetical protein 204390..204638 Mycobacterium leprae Br4923 7325858 YP_002502867.1 CDS pgi NC_011896.1 211177 212841 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(211177..212841) Mycobacterium leprae Br4923 7325866 YP_002502868.1 CDS MLBr_00151 NC_011896.1 213202 213519 R hypothetical protein complement(213202..213519) Mycobacterium leprae Br4923 7327382 YP_002502869.1 CDS MLBr_00152 NC_011896.1 214028 214216 D hypothetical protein 214028..214216 Mycobacterium leprae Br4923 7326275 YP_002502870.1 CDS uvrD NC_011896.1 214299 216635 D ATP-dependent DNA helicase 214299..216635 Mycobacterium leprae Br4923 7326276 YP_002502871.1 CDS MLBr_00154 NC_011896.1 217187 218188 R hypothetical protein complement(217187..218188) Mycobacterium leprae Br4923 7327308 YP_002502872.1 CDS sucC NC_011896.1 218485 219666 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 218485..219666 Mycobacterium leprae Br4923 7326277 YP_002502873.1 CDS sucD NC_011896.1 219686 220588 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 219686..220588 Mycobacterium leprae Br4923 7326005 YP_002502874.1 CDS MLBr_00158 NC_011896.1 221684 222628 D hypothetical protein 221684..222628 Mycobacterium leprae Br4923 7326278 YP_002502875.1 CDS MLBr_00159 NC_011896.1 222677 223969 D hypothetical protein 222677..223969 Mycobacterium leprae Br4923 7326279 YP_002502876.1 CDS purN NC_011896.1 223999 224646 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 223999..224646 Mycobacterium leprae Br4923 7326280 YP_002502877.1 CDS purH NC_011896.1 224643 226226 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 224643..226226 Mycobacterium leprae Br4923 7325042 YP_002502878.1 CDS MLBr_00162 NC_011896.1 227035 227313 R hypothetical protein complement(227035..227313) Mycobacterium leprae Br4923 7325038 YP_002502879.1 CDS MLBr_00169 NC_011896.1 234947 235549 D hypothetical protein 234947..235549 Mycobacterium leprae Br4923 7325220 YP_002502880.1 CDS rpmF NC_011896.1 240252 240425 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 240252..240425 Mycobacterium leprae Br4923 7326286 YP_002502881.1 CDS MLBr_00174 NC_011896.1 240546 241232 D two-component response regulator 240546..241232 Mycobacterium leprae Br4923 7326669 YP_002502882.1 CDS MLBr_00175 NC_011896.1 241232 242791 D two-component system sensor kinase 241232..242791 Mycobacterium leprae Br4923 7326287 YP_002502883.1 CDS MLBr_00176 NC_011896.1 243069 244217 D serine protease 243069..244217 Mycobacterium leprae Br4923 7326288 YP_002502884.1 CDS moaB NC_011896.1 244240 244785 D molybdenum cofactor biosynthesis protein 244240..244785 Mycobacterium leprae Br4923 7326289 YP_002502885.1 CDS mscL NC_011896.1 244802 245266 R forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel complement(244802..245266) Mycobacterium leprae Br4923 7324912 YP_002502886.1 CDS MLBr_00180 NC_011896.1 246064 246363 R hypothetical protein complement(246064..246363) Mycobacterium leprae Br4923 7326290 YP_002502887.1 CDS MLBr_00181 NC_011896.1 246438 247031 R hypothetical protein complement(246438..247031) Mycobacterium leprae Br4923 7326291 YP_002502888.1 CDS galU NC_011896.1 247109 248029 D UTP-glucose-1-phosphate uridylyltransferase 247109..248029 Mycobacterium leprae Br4923 7326292 YP_002502889.1 CDS moeA NC_011896.1 248117 249391 D molybdopterin biosynthesis protein 248117..249391 Mycobacterium leprae Br4923 7325329 YP_002502890.1 CDS rimJ NC_011896.1 249422 250066 D acetyltransferase 249422..250066 Mycobacterium leprae Br4923 7324920 YP_002502891.1 CDS MLBr_00185 NC_011896.1 250236 251264 D hypothetical protein 250236..251264 Mycobacterium leprae Br4923 7326625 YP_002502892.1 CDS MLBr_00187 NC_011896.1 252673 253734 D hypothetical protein 252673..253734 Mycobacterium leprae Br4923 7326294 YP_002502893.1 CDS MLBr_00188 NC_011896.1 254043 254306 D hypothetical protein 254043..254306 Mycobacterium leprae Br4923 7326295 YP_002502894.1 CDS MLBr_00190 NC_011896.1 255140 255757 R hypothetical protein complement(255140..255757) Mycobacterium leprae Br4923 7326297 YP_002502895.1 CDS MLBr_00192 NC_011896.1 257050 258582 R hypothetical protein complement(257050..258582) Mycobacterium leprae Br4923 7327216 YP_002502896.1 CDS MLBr_00193 NC_011896.1 258661 259506 D hypothetical protein 258661..259506 Mycobacterium leprae Br4923 7326299 YP_002502897.1 CDS cspA NC_011896.1 264913 265116 D cold shock protein 264913..265116 Mycobacterium leprae Br4923 7326302 YP_002502898.1 CDS MLBr_00199 NC_011896.1 265228 265830 D hypothetical protein 265228..265830 Mycobacterium leprae Br4923 7326130 YP_002502899.1 CDS topA NC_011896.1 266048 268891 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 266048..268891 Mycobacterium leprae Br4923 7326303 YP_002502900.1 CDS MLBr_00201 NC_011896.1 268872 270464 R hypothetical protein complement(268872..270464) Mycobacterium leprae Br4923 7326029 YP_002502901.1 CDS MLBr_00202 NC_011896.1 270620 271837 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 270620..271837 Mycobacterium leprae Br4923 7326304 YP_002502902.1 CDS MLBr_00203 NC_011896.1 273305 275014 R hypothetical protein complement(273305..275014) Mycobacterium leprae Br4923 7326023 YP_002502903.1 CDS rmlB2 NC_011896.1 275064 276023 D sugar-nucleotide dehydratase 275064..276023 Mycobacterium leprae Br4923 7326306 YP_002502904.1 CDS MLBr_00205 NC_011896.1 276722 277792 R hypothetical protein complement(276722..277792) Mycobacterium leprae Br4923 7326629 YP_002502905.1 CDS MLBr_00207 NC_011896.1 279066 279785 D glycosyltransferase 279066..279785 Mycobacterium leprae Br4923 7326308 YP_002502906.1 CDS MLBr_00208 NC_011896.1 279799 280140 D hypothetical protein 279799..280140 Mycobacterium leprae Br4923 7326309 YP_002502907.1 CDS ppa NC_011896.1 281558 282046 R inorganic pyrophosphatase complement(281558..282046) Mycobacterium leprae Br4923 7326311 YP_002502908.1 CDS MLBr_00211 NC_011896.1 282172 283557 D carboxypeptidase 282172..283557 Mycobacterium leprae Br4923 7324983 YP_002502909.1 CDS mesJ NC_011896.1 284595 285566 D hypothetical protein 284595..285566 Mycobacterium leprae Br4923 7326313 YP_002502910.1 CDS hpt NC_011896.1 285599 286240 D hypoxanthine phosphoribosyltransferase 285599..286240 Mycobacterium leprae Br4923 7325451 YP_002502911.1 CDS MLBr_00217 NC_011896.1 288693 288938 D hypothetical protein 288693..288938 Mycobacterium leprae Br4923 7326315 YP_002502912.1 CDS MLBr_00218 NC_011896.1 289844 290230 R hypothetical protein complement(289844..290230) Mycobacterium leprae Br4923 7326316 YP_002502913.1 CDS ftsH NC_011896.1 293708 296080 D integral membrane peptidase 293708..296080 Mycobacterium leprae Br4923 7326320 YP_002502914.1 CDS folE NC_011896.1 296097 296714 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 296097..296714 Mycobacterium leprae Br4923 7325313 YP_002502915.1 CDS folP NC_011896.1 296711 297565 D dihydropteroate synthase 296711..297565 Mycobacterium leprae Br4923 7325304 YP_002502916.1 CDS folB NC_011896.1 297558 297956 D dihydroneopterin aldolase 297558..297956 Mycobacterium leprae Br4923 7325306 YP_002502917.1 CDS folK NC_011896.1 297956 298531 D 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 297956..298531 Mycobacterium leprae Br4923 7325301 YP_002502918.1 CDS MLBr_00227 NC_011896.1 298531 299007 D hypothetical protein 298531..299007 Mycobacterium leprae Br4923 7325305 YP_002502919.1 CDS MLBr_00228 NC_011896.1 299153 300451 D hypothetical protein 299153..300451 Mycobacterium leprae Br4923 7326321 YP_002502920.1 CDS MLBr_00229 NC_011896.1 300552 301481 D hypothetical protein 300552..301481 Mycobacterium leprae Br4923 7326322 YP_002502921.1 CDS panC NC_011896.1 301478 302419 D catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 301478..302419 Mycobacterium leprae Br4923 7326323 YP_002502922.1 CDS panD NC_011896.1 302419 302847 D Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 302419..302847 Mycobacterium leprae Br4923 7327349 YP_002502923.1 CDS MLBr_00232 NC_011896.1 302850 303674 D type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 302850..303674 Mycobacterium leprae Br4923 7327350 YP_002502924.1 CDS lysS NC_011896.1 303755 305278 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 303755..305278 Mycobacterium leprae Br4923 7326324 YP_002502925.1 CDS lsr2 NC_011896.1 305383 305721 D lsr2 protein (15 kDa antigen) 305383..305721 Mycobacterium leprae Br4923 7325430 YP_002502926.1 CDS clpC NC_011896.1 306018 308564 D ATP-dependent Clp protease 306018..308564 Mycobacterium leprae Br4923 7325427 YP_002502927.1 CDS pabB NC_011896.1 309670 310926 R catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I complement(309670..310926) Mycobacterium leprae Br4923 7327274 YP_002502928.1 CDS metS NC_011896.1 312224 313837 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(312224..313837) Mycobacterium leprae Br4923 7326325 YP_002502929.1 CDS MLBr_00239 NC_011896.1 313926 314714 D hypothetical protein 313926..314714 Mycobacterium leprae Br4923 7325458 YP_002502930.1 CDS MLBr_00240 NC_011896.1 314964 316091 D hypothetical protein 314964..316091 Mycobacterium leprae Br4923 7326326 YP_002502931.1 CDS ksgA NC_011896.1 316064 316984 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 316064..316984 Mycobacterium leprae Br4923 7326327 YP_002502932.1 CDS MLBr_00242 NC_011896.1 317058 317993 D catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 317058..317993 Mycobacterium leprae Br4923 7324725 YP_002502933.1 CDS MLBr_00243 NC_011896.1 318236 319870 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 318236..319870 Mycobacterium leprae Br4923 7326328 YP_002502934.1 CDS pth NC_011896.1 319981 320580 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(319981..320580) Mycobacterium leprae Br4923 7326329 YP_002502935.1 CDS rplY NC_011896.1 320593 321240 R the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 complement(320593..321240) Mycobacterium leprae Br4923 7325029 YP_002502936.1 CDS lpqT NC_011896.1 322415 323071 R lipoprotein complement(322415..323071) Mycobacterium leprae Br4923 7326663 YP_002502937.1 CDS arsC NC_011896.1 323108 323422 R arsenate reductase complement(323108..323422) Mycobacterium leprae Br4923 7325421 YP_002502938.1 CDS prsA NC_011896.1 323478 324461 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(323478..324461) Mycobacterium leprae Br4923 7327238 YP_002502939.1 CDS glmU NC_011896.1 324572 326050 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(324572..326050) Mycobacterium leprae Br4923 7325018 YP_002502940.1 CDS mfd NC_011896.1 328083 331757 D transcription-repair coupling factor 328083..331757 Mycobacterium leprae Br4923 7326331 YP_002502941.1 CDS eno NC_011896.1 333767 335110 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 333767..335110 Mycobacterium leprae Br4923 7325422 YP_002502942.1 CDS MLBr_00256 NC_011896.1 335145 335828 D hypothetical protein 335145..335828 Mycobacterium leprae Br4923 7325227 YP_002502943.1 CDS MLBr_00257 NC_011896.1 335821 336324 D hypothetical protein 335821..336324 Mycobacterium leprae Br4923 7326333 YP_002502944.1 CDS MLBr_00258 NC_011896.1 336321 337274 D hypothetical protein 336321..337274 Mycobacterium leprae Br4923 7326334 YP_002502945.1 CDS MLBr_00265 NC_011896.1 345724 345936 D hypothetical protein 345724..345936 Mycobacterium leprae Br4923 7326340 YP_002502946.1 CDS MLBr_00269 NC_011896.1 353023 354033 R F420-dependent glucose-6-phosphate dehydrogenase complement(353023..354033) Mycobacterium leprae Br4923 7325028 YP_002502947.1 CDS MLBr_00270 NC_011896.1 354121 354876 D hypothetical protein 354121..354876 Mycobacterium leprae Br4923 7326343 YP_002502948.1 CDS MLBr_00271 NC_011896.1 354865 355236 R hypothetical protein complement(354865..355236) Mycobacterium leprae Br4923 7326344 YP_002502949.1 CDS metZ NC_011896.1 357573 358793 R O-succinylhomoserine sulfhydrylase complement(357573..358793) Mycobacterium leprae Br4923 7326347 YP_002502950.1 CDS MLBr_00276 NC_011896.1 358850 359293 R hypothetical protein complement(358850..359293) Mycobacterium leprae Br4923 7324897 YP_002502951.1 CDS MLBr_00279 NC_011896.1 361313 361969 R hypothetical protein complement(361313..361969) Mycobacterium leprae Br4923 7326350 YP_002502952.1 CDS purA NC_011896.1 361966 363264 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(361966..363264) Mycobacterium leprae Br4923 7326351 YP_002502953.1 CDS MLBr_00281 NC_011896.1 363448 364137 D hypothetical protein 363448..364137 Mycobacterium leprae Br4923 7325032 YP_002502954.1 CDS MLBr_00283 NC_011896.1 364932 365738 D cation-efflux transporter component 364932..365738 Mycobacterium leprae Br4923 7326353 YP_002502955.1 CDS MLBr_00284 NC_011896.1 365876 366289 R hypothetical protein complement(365876..366289) Mycobacterium leprae Br4923 7326354 YP_002502956.1 CDS MLBr_00285 NC_011896.1 366401 367279 D hypothetical protein 366401..367279 Mycobacterium leprae Br4923 7326355 YP_002502957.1 CDS fba NC_011896.1 367295 368332 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(367295..368332) Mycobacterium leprae Br4923 7326273 YP_002502958.1 CDS MLBr_00287 NC_011896.1 368465 369133 D hypothetical protein 368465..369133 Mycobacterium leprae Br4923 7325287 YP_002502959.1 CDS MLBr_00291 NC_011896.1 372050 372442 R hypothetical protein complement(372050..372442) Mycobacterium leprae Br4923 7326359 YP_002502960.1 CDS MLBr_00292 NC_011896.1 373621 373860 R hypothetical protein complement(373621..373860) Mycobacterium leprae Br4923 7326360 YP_002502961.1 CDS MLBr_00293 NC_011896.1 375469 375678 R hypothetical protein complement(375469..375678) Mycobacterium leprae Br4923 7326361 YP_002502962.1 CDS thiC NC_011896.1 377503 379146 D required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 377503..379146 Mycobacterium leprae Br4923 7326362 YP_002502963.1 CDS thiD NC_011896.1 379143 379982 D catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 379143..379982 Mycobacterium leprae Br4923 7326013 YP_002502964.1 CDS thiG NC_011896.1 380661 381446 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(380661..381446) Mycobacterium leprae Br4923 7326363 YP_002502965.1 CDS MLBr_00298 NC_011896.1 381439 381663 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(381439..381663) Mycobacterium leprae Br4923 7326016 YP_002502966.1 CDS MLBr_00299 NC_011896.1 381671 382693 R oxidoreductase complement(381671..382693) Mycobacterium leprae Br4923 7326364 YP_002502967.1 CDS thiE NC_011896.1 382851 383558 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 382851..383558 Mycobacterium leprae Br4923 7326365 YP_002502968.1 CDS glnH NC_011896.1 385666 386646 D glutamine-binding protein 385666..386646 Mycobacterium leprae Br4923 7326366 YP_002502969.1 CDS pknG NC_011896.1 386646 388949 D serine-threonine protein kinase 386646..388949 Mycobacterium leprae Br4923 7325356 YP_002502970.1 CDS MLBr_00308 NC_011896.1 394474 395178 D hypothetical protein 394474..395178 Mycobacterium leprae Br4923 7326369 YP_002502971.1 CDS pssA NC_011896.1 397063 397965 R CDP-diacylglycerol-serine o-phosphatidyltransferase complement(397063..397965) Mycobacterium leprae Br4923 7326371 YP_002502972.1 CDS MLBr_00311 NC_011896.1 397962 398693 R catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase complement(397962..398693) Mycobacterium leprae Br4923 7325019 YP_002502973.1 CDS MLBr_00314 NC_011896.1 400788 401795 R esterase complement(400788..401795) Mycobacterium leprae Br4923 7326373 YP_002502974.1 CDS MLBr_00315 NC_011896.1 403715 404629 R short chain dehydrogenase complement(403715..404629) Mycobacterium leprae Br4923 7326374 YP_002502975.1 CDS MLBr_00316 NC_011896.1 404724 405326 D TetR family transcriptional regulator 404724..405326 Mycobacterium leprae Br4923 7326375 YP_002502976.1 CDS groEL NC_011896.1 405535 407160 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 405535..407160 Mycobacterium leprae Br4923 7326376 YP_002502977.1 CDS lpqE NC_011896.1 409451 410002 R lipoprotein complement(409451..410002) Mycobacterium leprae Br4923 7326607 YP_002502978.1 CDS MLBr_00320 NC_011896.1 410363 410860 D transcription factor 410363..410860 Mycobacterium leprae Br4923 7325417 YP_002502979.1 CDS ispD NC_011896.1 410879 411604 D 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 410879..411604 Mycobacterium leprae Br4923 7326377 YP_002502980.1 CDS ispF NC_011896.1 411601 412077 D catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 411601..412077 Mycobacterium leprae Br4923 7326378 YP_002502981.1 CDS cysS NC_011896.1 412132 413553 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 412132..413553 Mycobacterium leprae Br4923 7326379 YP_002502982.1 CDS MLBr_00324 NC_011896.1 413636 414472 D methyltransferase 413636..414472 Mycobacterium leprae Br4923 7326153 YP_002502983.1 CDS MLBr_00325 NC_011896.1 414874 415137 D hypothetical protein 414874..415137 Mycobacterium leprae Br4923 7326380 YP_002502984.1 CDS MLBr_00333 NC_011896.1 423187 423945 R LamB/YcsF family protein complement(423187..423945) Mycobacterium leprae Br4923 7326386 YP_002502985.1 CDS MLBr_00335 NC_011896.1 424876 425736 R ABC-transporter transmembrane protein complement(424876..425736) Mycobacterium leprae Br4923 7327408 YP_002502986.1 CDS MLBr_00336 NC_011896.1 425736 426563 R ABC-transporter ATP-binding protein complement(425736..426563) Mycobacterium leprae Br4923 7326388 YP_002502987.1 CDS MLBr_00337 NC_011896.1 426572 427480 R periplasmic solute-binding proteins complement(426572..427480) Mycobacterium leprae Br4923 7326389 YP_002502988.1 CDS MLBr_00348 NC_011896.1 438271 439323 D coenzyme F420-dependent oxidoreductase 438271..439323 Mycobacterium leprae Br4923 7326399 YP_002502989.1 CDS ilvX NC_011896.1 447423 448970 D thiamine-pyrophosphate requiring enzyme; hypothetical protein 447423..448970 Mycobacterium leprae Br4923 7326403 YP_002502990.1 CDS MLBr_00363 NC_011896.1 456427 456741 D hypothetical protein 456427..456741 Mycobacterium leprae Br4923 7325445 YP_002502991.1 CDS rplM NC_011896.1 456993 457436 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 456993..457436 Mycobacterium leprae Br4923 7326408 YP_002502992.1 CDS rpsI NC_011896.1 457433 457894 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 457433..457894 Mycobacterium leprae Br4923 7326651 YP_002502993.1 CDS glmM NC_011896.1 458001 459392 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 458001..459392 Mycobacterium leprae Br4923 7325949 YP_002502994.1 CDS MLBr_00369 NC_011896.1 461194 461550 R hypothetical protein complement(461194..461550) Mycobacterium leprae Br4923 7326410 YP_002502995.1 CDS MLBr_00370 NC_011896.1 461954 462823 R hypothetical protein complement(461954..462823) Mycobacterium leprae Br4923 7326411 YP_002502996.1 CDS glmS NC_011896.1 462988 464865 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 462988..464865 Mycobacterium leprae Br4923 7326412 YP_002502997.1 CDS MLBr_00373 NC_011896.1 465211 466632 D hypothetical protein 465211..466632 Mycobacterium leprae Br4923 7326413 YP_002502998.1 CDS alr NC_011896.1 468141 469307 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 468141..469307 Mycobacterium leprae Br4923 7325327 YP_002502999.1 CDS MLBr_00376 NC_011896.1 469297 470298 D hypothetical protein 469297..470298 Mycobacterium leprae Br4923 7327205 YP_002503000.1 CDS MLBr_00377 NC_011896.1 470291 470776 D hypothetical protein 470291..470776 Mycobacterium leprae Br4923 7326415 YP_002503001.1 CDS MLBr_00378 NC_011896.1 470773 471852 D acetyltransferase 470773..471852 Mycobacterium leprae Br4923 7326416 YP_002503002.1 CDS gcp NC_011896.1 471849 472904 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 471849..472904 Mycobacterium leprae Br4923 7326417 YP_002503003.1 CDS groES NC_011896.1 473186 473488 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 473186..473488 Mycobacterium leprae Br4923 7325334 YP_002503004.1 CDS groEL NC_011896.1 473567 475180 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL 473567..475180 Mycobacterium leprae Br4923 7324660 YP_002503005.1 CDS whiB3 NC_011896.1 475780 476088 R transcriptional regulator complement(475780..476088) Mycobacterium leprae Br4923 7324658 YP_002503006.1 CDS MLBr_00383 NC_011896.1 476449 477294 D hypothetical protein 476449..477294 Mycobacterium leprae Br4923 7327317 YP_002503007.1 CDS MLBr_00386 NC_011896.1 480102 480515 R hypothetical protein complement(480102..480515) Mycobacterium leprae Br4923 7326419 YP_002503008.1 CDS guaB2 NC_011896.1 480670 482259 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 480670..482259 Mycobacterium leprae Br4923 7326420 YP_002503009.1 CDS guaB3 NC_011896.1 482283 483395 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 482283..483395 Mycobacterium leprae Br4923 7324665 YP_002503010.1 CDS choD NC_011896.1 483460 485169 D cholesterol oxidase 483460..485169 Mycobacterium leprae Br4923 7324666 YP_002503011.1 CDS MLBr_00392 NC_011896.1 486272 488650 R sugar phosphorylase complement(486272..488650) Mycobacterium leprae Br4923 7326422 YP_002503012.1 CDS MLBr_00393 NC_011896.1 488664 489449 R hydrolase complement(488664..489449) Mycobacterium leprae Br4923 7326423 YP_002503013.1 CDS MLBr_00394 NC_011896.1 489924 490436 R hypothetical protein complement(489924..490436) Mycobacterium leprae Br4923 7326424 YP_002503014.1 CDS guaA NC_011896.1 491052 492641 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 491052..492641 Mycobacterium leprae Br4923 7326425 YP_002503015.1 CDS MLBr_00396 NC_011896.1 492723 493832 R hypothetical protein complement(492723..493832) Mycobacterium leprae Br4923 7324663 YP_002503016.1 CDS MLBr_00397 NC_011896.1 493948 495756 R transporter protein complement(493948..495756) Mycobacterium leprae Br4923 7326426 YP_002503017.1 CDS MLBr_00398 NC_011896.1 496069 497106 R D-ribose-binding protein complement(496069..497106) Mycobacterium leprae Br4923 7326427 YP_002503018.1 CDS MLBr_00405 NC_011896.1 503226 504410 D hypothetical protein 503226..504410 Mycobacterium leprae Br4923 7326111 YP_002503019.1 CDS MLBr_00406 NC_011896.1 504468 504788 D hypothetical protein 504468..504788 Mycobacterium leprae Br4923 7326433 YP_002503020.1 CDS MLBr_00407 NC_011896.1 504802 505452 D hypothetical protein 504802..505452 Mycobacterium leprae Br4923 7326434 YP_002503021.1 CDS MLBr_00410 NC_011896.1 508336 508638 D PE-family protein 508336..508638 Mycobacterium leprae Br4923 7326437 YP_002503022.1 CDS MLBr_00411 NC_011896.1 508764 509990 D serine-rich protein 508764..509990 Mycobacterium leprae Br4923 7325622 YP_002503023.1 CDS otsB2 NC_011896.1 511993 513282 R trehalose-6-phosphate phosphatase complement(511993..513282) Mycobacterium leprae Br4923 7325624 YP_002503024.1 CDS MLBr_00418 NC_011896.1 517653 518285 D oxidoreductase 517653..518285 Mycobacterium leprae Br4923 7325626 YP_002503025.1 CDS MLBr_00419 NC_011896.1 518423 518899 R tRNA/rRNA methyltransferase complement(518423..518899) Mycobacterium leprae Br4923 7325627 YP_002503026.1 CDS bcp NC_011896.1 523812 524297 R antioxidant protein complement(523812..524297) Mycobacterium leprae Br4923 7325632 YP_002503027.1 CDS MLBr_00425 NC_011896.1 524425 524652 D hypothetical protein 524425..524652 Mycobacterium leprae Br4923 7327257 YP_002503028.1 CDS lppS NC_011896.1 524938 526152 D hypothetical protein 524938..526152 Mycobacterium leprae Br4923 7325432 YP_002503029.1 CDS MLBr_00427 NC_011896.1 526303 526950 R 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease complement(526303..526950) Mycobacterium leprae Br4923 7324689 YP_002503030.1 CDS MLBr_00429 NC_011896.1 528630 529436 R oxidoreductase complement(528630..529436) Mycobacterium leprae Br4923 7325635 YP_002503031.1 CDS MLBr_00430 NC_011896.1 529529 530893 D hypothetical protein 529529..530893 Mycobacterium leprae Br4923 7325636 YP_002503032.1 CDS MLBr_00431 NC_011896.1 530925 531704 R hypothetical protein complement(530925..531704) Mycobacterium leprae Br4923 7325637 YP_002503033.1 CDS MLBr_00447 NC_011896.1 547321 547797 D hypothetical protein 547321..547797 Mycobacterium leprae Br4923 7325643 YP_002503034.1 CDS MLBr_00448 NC_011896.1 548001 548273 D hypothetical protein 548001..548273 Mycobacterium leprae Br4923 7325644 YP_002503035.1 CDS MLBr_00450 NC_011896.1 550202 551125 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(550202..551125) Mycobacterium leprae Br4923 7326012 YP_002503036.1 CDS MLBr_00451 NC_011896.1 551200 552249 R hypothetical protein complement(551200..552249) Mycobacterium leprae Br4923 7325646 YP_002503037.1 CDS MLBr_00452 NC_011896.1 552249 553373 R glycosyltransferase complement(552249..553373) Mycobacterium leprae Br4923 7325647 YP_002503038.1 CDS MLBr_00453 NC_011896.1 553383 554345 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(553383..554345) Mycobacterium leprae Br4923 7325648 YP_002503039.1 CDS pgsA NC_011896.1 554342 555061 R phosphatidyltransferase complement(554342..555061) Mycobacterium leprae Br4923 7325649 YP_002503040.1 CDS MLBr_00455 NC_011896.1 555058 555678 R hypothetical protein complement(555058..555678) Mycobacterium leprae Br4923 7327386 YP_002503041.1 CDS thrS NC_011896.1 555671 557779 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(555671..557779) Mycobacterium leprae Br4923 7325650 YP_002503042.1 CDS MLBr_00458 NC_011896.1 558372 559277 R oxidoreductase complement(558372..559277) Mycobacterium leprae Br4923 7325651 YP_002503043.1 CDS MLBr_00464 NC_011896.1 561817 562104 D hypothetical protein 561817..562104 Mycobacterium leprae Br4923 7325657 YP_002503044.1 CDS MLBr_00466 NC_011896.1 563641 564546 D hypothetical protein 563641..564546 Mycobacterium leprae Br4923 7325659 YP_002503045.1 CDS dedA NC_011896.1 564592 565236 D hypothetical protein 564592..565236 Mycobacterium leprae Br4923 7325660 YP_002503046.1 CDS MLBr_00468 NC_011896.1 566066 566848 R hypothetical protein complement(566066..566848) Mycobacterium leprae Br4923 7326163 YP_002503047.1 CDS MLBr_00470 NC_011896.1 571612 571902 R hypothetical protein complement(571612..571902) Mycobacterium leprae Br4923 7325662 YP_002503048.1 CDS MLBr_00472 NC_011896.1 574041 574283 D hypothetical protein 574041..574283 Mycobacterium leprae Br4923 7325664 YP_002503049.1 CDS MLBr_00473 NC_011896.1 574547 574819 D hypothetical protein 574547..574819 Mycobacterium leprae Br4923 7325665 YP_002503050.1 CDS MLBr_00474 NC_011896.1 575478 576149 D with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 575478..576149 Mycobacterium leprae Br4923 7325666 YP_002503051.1 CDS MLBr_00475 NC_011896.1 576370 577125 D hypothetical protein 576370..577125 Mycobacterium leprae Br4923 7325667 YP_002503052.1 CDS ruvC NC_011896.1 581233 581799 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 581233..581799 Mycobacterium leprae Br4923 7325672 YP_002503053.1 CDS ruvA NC_011896.1 581796 582407 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 581796..582407 Mycobacterium leprae Br4923 7325964 YP_002503054.1 CDS ruvB NC_011896.1 582404 583453 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 582404..583453 Mycobacterium leprae Br4923 7325962 YP_002503055.1 CDS fadD9 NC_011896.1 584390 587956 R acyl-CoA synthetase complement(584390..587956) Mycobacterium leprae Br4923 7325963 YP_002503056.1 CDS gabT NC_011896.1 588052 589392 R catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase complement(588052..589392) Mycobacterium leprae Br4923 7325262 YP_002503057.1 CDS yajC NC_011896.1 589661 590005 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 589661..590005 Mycobacterium leprae Br4923 7325326 YP_002503058.1 CDS secD NC_011896.1 590045 591838 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 590045..591838 Mycobacterium leprae Br4923 7325673 YP_002503059.1 CDS secF NC_011896.1 591843 593258 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 591843..593258 Mycobacterium leprae Br4923 7325975 YP_002503060.1 CDS MLBr_00489 NC_011896.1 593303 594970 D lipoprotein 593303..594970 Mycobacterium leprae Br4923 7325977 YP_002503061.1 CDS relA NC_011896.1 595616 597979 D GTP pyrophosphokinase 595616..597979 Mycobacterium leprae Br4923 7327215 YP_002503062.1 CDS ppiB NC_011896.1 598038 598925 R peptidyl-prolyl cis-trans isomerase complement(598038..598925) Mycobacterium leprae Br4923 7326615 YP_002503063.1 CDS MLBr_00493 NC_011896.1 599089 599745 D hydrolase 599089..599745 Mycobacterium leprae Br4923 7325001 YP_002503064.1 CDS hisS NC_011896.1 599749 601032 D catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 599749..601032 Mycobacterium leprae Br4923 7325675 YP_002503065.1 CDS aspS NC_011896.1 606848 608617 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 606848..608617 Mycobacterium leprae Br4923 7325680 YP_002503066.1 CDS MLBr_00508 NC_011896.1 617510 618451 D hypothetical protein 617510..618451 Mycobacterium leprae Br4923 7325685 YP_002503067.1 CDS MLBr_00510 NC_011896.1 619675 621096 D recombination factor protein RarA 619675..621096 Mycobacterium leprae Br4923 7325687 YP_002503068.1 CDS alaS NC_011896.1 622168 624894 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 622168..624894 Mycobacterium leprae Br4923 7325689 YP_002503069.1 CDS MLBr_00513 NC_011896.1 624895 625449 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 624895..625449 Mycobacterium leprae Br4923 7327198 YP_002503070.1 CDS MLBr_00514 NC_011896.1 625442 626707 D hypothetical protein 625442..626707 Mycobacterium leprae Br4923 7325690 YP_002503071.1 CDS aroE NC_011896.1 626685 627521 D AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 626685..627521 Mycobacterium leprae Br4923 7325691 YP_002503072.1 CDS aroF NC_011896.1 627750 628973 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 627750..628973 Mycobacterium leprae Br4923 7327233 YP_002503073.1 CDS aroK NC_011896.1 628981 629580 D catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 628981..629580 Mycobacterium leprae Br4923 7327234 YP_002503074.1 CDS aroB NC_011896.1 629577 630662 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 629577..630662 Mycobacterium leprae Br4923 7327236 YP_002503075.1 CDS aroD NC_011896.1 630662 631099 D catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 630662..631099 Mycobacterium leprae Br4923 7327231 YP_002503076.1 CDS MLBr_00520 NC_011896.1 631188 631796 R hypothetical protein complement(631188..631796) Mycobacterium leprae Br4923 7327232 YP_002503077.1 CDS pepQ NC_011896.1 631830 632960 D peptidase 631830..632960 Mycobacterium leprae Br4923 7325692 YP_002503078.1 CDS efp NC_011896.1 632976 633539 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 632976..633539 Mycobacterium leprae Br4923 7327375 YP_002503079.1 CDS nusB NC_011896.1 633542 634114 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 633542..634114 Mycobacterium leprae Br4923 7325221 YP_002503080.1 CDS adi NC_011896.1 634652 637504 D amino acid decarboxylase 634652..637504 Mycobacterium leprae Br4923 7327335 YP_002503081.1 CDS MLBr_00525 NC_011896.1 637501 637677 D hypothetical protein 637501..637677 Mycobacterium leprae Br4923 7327191 YP_002503082.1 CDS MLBr_00527 NC_011896.1 639687 639941 R hypothetical protein complement(639687..639941) Mycobacterium leprae Br4923 7325694 YP_002503083.1 CDS pyrB NC_011896.1 645590 646555 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 645590..646555 Mycobacterium leprae Br4923 7326274 YP_002503084.1 CDS pyrC NC_011896.1 646552 647844 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 646552..647844 Mycobacterium leprae Br4923 7325045 YP_002503085.1 CDS carA NC_011896.1 648431 649558 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 648431..649558 Mycobacterium leprae Br4923 7325699 YP_002503086.1 CDS carB NC_011896.1 649617 653006 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 649617..653006 Mycobacterium leprae Br4923 7327266 YP_002503087.1 CDS pyrF NC_011896.1 653003 653851 D type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 653003..653851 Mycobacterium leprae Br4923 7327267 YP_002503088.1 CDS PE NC_011896.1 654138 654446 D PE-family protein 654138..654446 Mycobacterium leprae Br4923 7325048 YP_002503089.1 CDS PPE NC_011896.1 654443 656059 D PPE family protein 654443..656059 Mycobacterium leprae Br4923 7327366 YP_002503090.1 CDS mihF NC_011896.1 656904 657221 D integration host factor 656904..657221 Mycobacterium leprae Br4923 7324989 YP_002503091.1 CDS gmk NC_011896.1 657275 657907 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 657275..657907 Mycobacterium leprae Br4923 7324902 YP_002503092.1 CDS MLBr_00542 NC_011896.1 657989 658321 D Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 657989..658321 Mycobacterium leprae Br4923 7326602 YP_002503093.1 CDS dfp NC_011896.1 658342 659601 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 658342..659601 Mycobacterium leprae Br4923 7325700 YP_002503094.1 CDS metK NC_011896.1 659730 660941 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 659730..660941 Mycobacterium leprae Br4923 7326170 YP_002503095.1 CDS priA NC_011896.1 664269 666224 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 664269..666224 Mycobacterium leprae Br4923 7325701 YP_002503096.1 CDS MLBr_00550 NC_011896.1 667340 667825 D marR-family transcriptional regulator 667340..667825 Mycobacterium leprae Br4923 7325702 YP_002503097.1 CDS MLBr_00551 NC_011896.1 668007 668831 R methyltransferase complement(668007..668831) Mycobacterium leprae Br4923 7326438 YP_002503098.1 CDS fmt NC_011896.1 669012 669968 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 669012..669968 Mycobacterium leprae Br4923 7326928 YP_002503099.1 CDS rpe NC_011896.1 671425 672099 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 671425..672099 Mycobacterium leprae Br4923 7325299 YP_002503100.1 CDS ribG NC_011896.1 672096 673115 D bifunctional riboflavin-specific deaminase/reductase 672096..673115 Mycobacterium leprae Br4923 7326639 YP_002503101.1 CDS MLBr_00556 NC_011896.1 673159 674688 R integral membrane drug transport protein complement(673159..674688) Mycobacterium leprae Br4923 7326623 YP_002503102.1 CDS lprG NC_011896.1 674688 675404 R lipoprotein complement(674688..675404) Mycobacterium leprae Br4923 7326929 YP_002503103.1 CDS ribC NC_011896.1 675561 676184 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 675561..676184 Mycobacterium leprae Br4923 7325423 YP_002503104.1 CDS ribA NC_011896.1 676311 677618 D bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 676311..677618 Mycobacterium leprae Br4923 7326621 YP_002503105.1 CDS ribH NC_011896.1 677615 678097 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 677615..678097 Mycobacterium leprae Br4923 7326620 YP_002503106.1 CDS MLBr_00561 NC_011896.1 678094 678564 D hypothetical protein 678094..678564 Mycobacterium leprae Br4923 7326624 YP_002503107.1 CDS uvrC NC_011896.1 678879 680822 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 678879..680822 Mycobacterium leprae Br4923 7326930 YP_002503108.1 CDS MLBr_00563 NC_011896.1 680819 681715 D hypothetical protein 680819..681715 Mycobacterium leprae Br4923 7327307 YP_002503109.1 CDS MLBr_00564 NC_011896.1 681712 682791 D hypothetical protein 681712..682791 Mycobacterium leprae Br4923 7326931 YP_002503110.1 CDS MLBr_00565 NC_011896.1 682788 683765 D transcriptional regulator 682788..683765 Mycobacterium leprae Br4923 7326932 YP_002503111.1 CDS MLBr_00568 NC_011896.1 686822 687415 D hypothetical protein 686822..687415 Mycobacterium leprae Br4923 7326935 YP_002503112.1 CDS MLBr_00569 NC_011896.1 693620 694435 R hypothetical protein complement(693620..694435) Mycobacterium leprae Br4923 7326936 YP_002503113.1 CDS gap NC_011896.1 694898 695917 D glyceraldehyde 3-phosphate dehydrogenase 694898..695917 Mycobacterium leprae Br4923 7326937 YP_002503114.1 CDS pgk NC_011896.1 695920 697170 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 695920..697170 Mycobacterium leprae Br4923 7325330 YP_002503115.1 CDS tpiA NC_011896.1 697167 697952 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 697167..697952 Mycobacterium leprae Br4923 7327383 YP_002503116.1 CDS MLBr_00573 NC_011896.1 697936 698211 D hypothetical protein 697936..698211 Mycobacterium leprae Br4923 7327278 YP_002503117.1 CDS MLBr_00574 NC_011896.1 698208 698525 D hypothetical protein 698208..698525 Mycobacterium leprae Br4923 7326938 YP_002503118.1 CDS MLBr_00575 NC_011896.1 698683 698901 D hypothetical protein 698683..698901 Mycobacterium leprae Br4923 7326939 YP_002503119.1 CDS MLBr_00576 NC_011896.1 699717 699947 D hypothetical protein 699717..699947 Mycobacterium leprae Br4923 7326940 YP_002503120.1 CDS secG NC_011896.1 699959 700192 D preprotein translocase subunit SecG 699959..700192 Mycobacterium leprae Br4923 7326941 YP_002503121.1 CDS ppc NC_011896.1 700223 703027 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 700223..703027 Mycobacterium leprae Br4923 7326942 YP_002503122.1 CDS pgl NC_011896.1 703251 703994 R 6-phosphogluconolactonase complement(703251..703994) Mycobacterium leprae Br4923 7324984 YP_002503123.1 CDS MLBr_00580 NC_011896.1 704010 704807 R hypothetical protein complement(704010..704807) Mycobacterium leprae Br4923 7327384 YP_002503124.1 CDS tal NC_011896.1 706470 707597 R catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase complement(706470..707597) Mycobacterium leprae Br4923 7327329 YP_002503125.1 CDS tkt NC_011896.1 707614 709713 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(707614..709713) Mycobacterium leprae Br4923 7326010 YP_002503126.1 CDS ctaB NC_011896.1 709913 710878 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 709913..710878 Mycobacterium leprae Br4923 7326026 YP_002503127.1 CDS MLBr_00587 NC_011896.1 712677 713612 R hypothetical protein complement(712677..713612) Mycobacterium leprae Br4923 7326944 YP_002503128.1 CDS MLBr_00588 NC_011896.1 713867 714109 D hypothetical protein 713867..714109 Mycobacterium leprae Br4923 7326945 YP_002503129.1 CDS MLBr_00589 NC_011896.1 714243 715040 R hypothetical protein complement(714243..715040) Mycobacterium leprae Br4923 7326946 YP_002503130.1 CDS MLBr_00590 NC_011896.1 715040 715987 R ABC transporter ATP-binding protein complement(715040..715987) Mycobacterium leprae Br4923 7326947 YP_002503131.1 CDS MLBr_00591 NC_011896.1 715984 717765 R hypothetical protein complement(715984..717765) Mycobacterium leprae Br4923 7326948 YP_002503132.1 CDS MLBr_00592 NC_011896.1 717881 718645 D DNA-binding protein 717881..718645 Mycobacterium leprae Br4923 7326949 YP_002503133.1 CDS MLBr_00593 NC_011896.1 718697 721306 D hypothetical protein 718697..721306 Mycobacterium leprae Br4923 7326950 YP_002503134.1 CDS MLBr_00594 NC_011896.1 721303 722481 D hypothetical protein 721303..722481 Mycobacterium leprae Br4923 7326951 YP_002503135.1 CDS MLBr_00595 NC_011896.1 722478 723260 D ABC transporter ATP-binding protein 722478..723260 Mycobacterium leprae Br4923 7326952 YP_002503136.1 CDS MLBr_00596 NC_011896.1 723263 724519 D aminotransferase 723263..724519 Mycobacterium leprae Br4923 7326953 YP_002503137.1 CDS MLBr_00597 NC_011896.1 724516 725013 D hypothetical protein 724516..725013 Mycobacterium leprae Br4923 7326954 YP_002503138.1 CDS MLBr_00598 NC_011896.1 724988 725335 D hypothetical protein 724988..725335 Mycobacterium leprae Br4923 7326955 YP_002503139.1 CDS MLBr_00603 NC_011896.1 735012 736127 D hypothetical protein 735012..736127 Mycobacterium leprae Br4923 7326959 YP_002503140.1 CDS rpsT NC_011896.1 736164 736424 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(736164..736424) Mycobacterium leprae Br4923 7326960 YP_002503141.1 CDS MLBr_00605 NC_011896.1 736559 738244 D hypothetical protein 736559..738244 Mycobacterium leprae Br4923 7325960 YP_002503142.1 CDS MLBr_00606 NC_011896.1 738244 739221 D hypothetical protein 738244..739221 Mycobacterium leprae Br4923 7326961 YP_002503143.1 CDS MLBr_00607 NC_011896.1 739221 740060 D hypothetical protein 739221..740060 Mycobacterium leprae Br4923 7326962 YP_002503144.1 CDS lepA NC_011896.1 742725 744665 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 742725..744665 Mycobacterium leprae Br4923 7326966 YP_002503145.1 CDS MLBr_00614 NC_011896.1 747786 748073 D hypothetical protein 747786..748073 Mycobacterium leprae Br4923 7326968 YP_002503146.1 CDS subI NC_011896.1 748391 749437 D sulfate-binding protein 748391..749437 Mycobacterium leprae Br4923 7326969 YP_002503147.1 CDS mtb12 NC_011896.1 753541 754044 D hypothetical protein 753541..754044 Mycobacterium leprae Br4923 7326970 YP_002503148.1 CDS hrcA NC_011896.1 756779 757810 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 756779..757810 Mycobacterium leprae Br4923 7326973 YP_002503149.1 CDS dnaJ2 NC_011896.1 757882 759018 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 757882..759018 Mycobacterium leprae Br4923 7324694 YP_002503150.1 CDS MLBr_00626 NC_011896.1 759050 759823 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 759050..759823 Mycobacterium leprae Br4923 7326180 YP_002503151.1 CDS phoH NC_011896.1 760123 761172 D phoH-family protein 760123..761172 Mycobacterium leprae Br4923 7326974 YP_002503152.1 CDS MLBr_00628 NC_011896.1 761203 761739 D metalloprotease 761203..761739 Mycobacterium leprae Br4923 7327392 YP_002503153.1 CDS MLBr_00630 NC_011896.1 763041 763367 D hypothetical protein 763041..763367 Mycobacterium leprae Br4923 7326976 YP_002503154.1 CDS era NC_011896.1 763485 764393 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 763485..764393 Mycobacterium leprae Br4923 7326977 YP_002503155.1 CDS recO NC_011896.1 765920 766726 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 765920..766726 Mycobacterium leprae Br4923 7327207 YP_002503156.1 CDS MLBr_00634 NC_011896.1 766719 767609 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 766719..767609 Mycobacterium leprae Br4923 7326978 YP_002503157.1 CDS uvrD2 NC_011896.1 769127 771280 D ATP-dependent DNA helicase 769127..771280 Mycobacterium leprae Br4923 7326982 YP_002503158.1 CDS MLBr_00638 NC_011896.1 771435 771737 D hypothetical protein 771435..771737 Mycobacterium leprae Br4923 7327309 YP_002503159.1 CDS whiB7 NC_011896.1 771731 772000 D transcriptional regulator 771731..772000 Mycobacterium leprae Br4923 7326983 YP_002503160.1 CDS MLBr_00640 NC_011896.1 772077 773498 R hypothetical protein complement(772077..773498) Mycobacterium leprae Br4923 7327318 YP_002503161.1 CDS MLBr_00642 NC_011896.1 774515 775954 R hypothetical protein complement(774515..775954) Mycobacterium leprae Br4923 7326985 YP_002503162.1 CDS MLBr_00643 NC_011896.1 776017 777039 D hypothetical protein 776017..777039 Mycobacterium leprae Br4923 7326986 YP_002503163.1 CDS MLBr_00644 NC_011896.1 777185 780136 D hypothetical protein 777185..780136 Mycobacterium leprae Br4923 7326987 YP_002503164.1 CDS MLBr_00656 NC_011896.1 793601 793882 R hypothetical protein complement(793601..793882) Mycobacterium leprae Br4923 7326997 YP_002503165.1 CDS MLBr_00659 NC_011896.1 795546 795872 R hypothetical protein complement(795546..795872) Mycobacterium leprae Br4923 7325242 YP_002503166.1 CDS fadE23 NC_011896.1 796056 797258 R acyl-CoA dehydrogenase complement(796056..797258) Mycobacterium leprae Br4923 7326999 YP_002503167.1 CDS fadE24 NC_011896.1 797301 798698 R acyl-CoA dehydrogenase complement(797301..798698) Mycobacterium leprae Br4923 7325270 YP_002503168.1 CDS MLBr_00662 NC_011896.1 798775 799542 R monophosphatase complement(798775..799542) Mycobacterium leprae Br4923 7325271 YP_002503169.1 CDS MLBr_00663 NC_011896.1 799670 799984 D hypothetical protein 799670..799984 Mycobacterium leprae Br4923 7327000 YP_002503170.1 CDS MLBr_00664 NC_011896.1 800125 800388 D hypothetical protein 800125..800388 Mycobacterium leprae Br4923 7327001 YP_002503171.1 CDS fprA NC_011896.1 801985 803355 R NADPH-ferredoxin reductase complement(801985..803355) Mycobacterium leprae Br4923 7327003 YP_002503172.1 CDS prfB NC_011896.1 803535 804659 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 803535..804659 Mycobacterium leprae Br4923 7325309 YP_002503173.1 CDS ftsE NC_011896.1 805929 806618 D cell division ATP-binding protein 805929..806618 Mycobacterium leprae Br4923 7327004 YP_002503174.1 CDS ftsX NC_011896.1 806619 807512 D hypothetical protein 806619..807512 Mycobacterium leprae Br4923 7325312 YP_002503175.1 CDS smpB NC_011896.1 807515 807997 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 807515..807997 Mycobacterium leprae Br4923 7325316 YP_002503176.1 CDS folD NC_011896.1 810701 811549 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 810701..811549 Mycobacterium leprae Br4923 7327006 YP_002503177.1 CDS MLBr_00675 NC_011896.1 811552 811827 D hypothetical protein 811552..811827 Mycobacterium leprae Br4923 7325303 YP_002503178.1 CDS MLBr_00676 NC_011896.1 811824 812300 R hypothetical protein complement(811824..812300) Mycobacterium leprae Br4923 7327007 YP_002503179.1 CDS MLBr_00678 NC_011896.1 813441 813968 R hypothetical protein complement(813441..813968) Mycobacterium leprae Br4923 7326192 YP_002503180.1 CDS MLBr_00679 NC_011896.1 814154 814381 D hypothetical protein 814154..814381 Mycobacterium leprae Br4923 7326193 YP_002503181.1 CDS metX NC_011896.1 817118 818266 R Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase complement(817118..818266) Mycobacterium leprae Br4923 7326196 YP_002503182.1 CDS MLBr_00685 NC_011896.1 821188 822099 R hydrolase complement(821188..822099) Mycobacterium leprae Br4923 7324702 YP_002503183.1 CDS trpS NC_011896.1 822135 823166 D catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 822135..823166 Mycobacterium leprae Br4923 7326197 YP_002503184.1 CDS MLBr_00687 NC_011896.1 823178 824119 D hypothetical protein 823178..824119 Mycobacterium leprae Br4923 7327285 YP_002503185.1 CDS MLBr_00691 NC_011896.1 827886 829121 R D-alanyl-D-alanine carboxypeptidase complement(827886..829121) Mycobacterium leprae Br4923 7326007 YP_002503186.1 CDS sdhB NC_011896.1 833881 834675 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit complement(833881..834675) Mycobacterium leprae Br4923 7326203 YP_002503187.1 CDS sdhA NC_011896.1 834675 836429 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(834675..836429) Mycobacterium leprae Br4923 7325970 YP_002503188.1 CDS sdhD NC_011896.1 836450 836941 R succinate dehydrogenase hydrophobic membrane anchor protei complement(836450..836941) Mycobacterium leprae Br4923 7325969 YP_002503189.1 CDS sdhC NC_011896.1 836938 837399 R succinate dehydrogenase cytochrome B-556 subunit complement(836938..837399) Mycobacterium leprae Br4923 7325972 YP_002503190.1 CDS add NC_011896.1 837688 838776 D catalyzes the formation of inosine from adenosine; adenosine deaminase 837688..838776 Mycobacterium leprae Br4923 7325971 YP_002503191.1 CDS MLBr_00703 NC_011896.1 840891 842162 R hypothetical protein complement(840891..842162) Mycobacterium leprae Br4923 7326205 YP_002503192.1 CDS pmmB NC_011896.1 843856 845472 R phospho-sugar mutase complement(843856..845472) Mycobacterium leprae Br4923 7327301 YP_002503193.1 CDS deoD NC_011896.1 845469 846275 R catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase complement(845469..846275) Mycobacterium leprae Br4923 7324974 YP_002503194.1 CDS MLBr_00711 NC_011896.1 849837 850316 R hypothetical protein complement(849837..850316) Mycobacterium leprae Br4923 7326208 YP_002503195.1 CDS glpD NC_011896.1 851957 853714 D glycerol-3-phosphate dehydrogenase 851957..853714 Mycobacterium leprae Br4923 7325405 YP_002503196.1 CDS lpqC NC_011896.1 854785 855699 D hydrolase 854785..855699 Mycobacterium leprae Br4923 7326210 YP_002503197.1 CDS MLBr_00717 NC_011896.1 859926 860597 R TetR family transcriptional regulator complement(859926..860597) Mycobacterium leprae Br4923 7325384 YP_002503198.1 CDS bccA NC_011896.1 867705 869501 R acetyl/propionyl CoA carboxylase subunit alpha complement(867705..869501) Mycobacterium leprae Br4923 7325988 YP_002503199.1 CDS sseA NC_011896.1 870037 870927 R thiosulfate sulfurtransferase complement(870037..870927) Mycobacterium leprae Br4923 7326216 YP_002503200.1 CDS MLBr_00729 NC_011896.1 871128 871769 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(871128..871769) Mycobacterium leprae Br4923 7326002 YP_002503201.1 CDS MLBr_00730 NC_011896.1 871766 872020 R hypothetical protein complement(871766..872020) Mycobacterium leprae Br4923 7326217 YP_002503202.1 CDS accD5 NC_011896.1 872017 873666 R acetyl/propionyl CoA carboxylase subunit beta complement(872017..873666) Mycobacterium leprae Br4923 7326218 YP_002503203.1 CDS birA NC_011896.1 873729 874553 D biotin apo-protein ligase 873729..874553 Mycobacterium leprae Br4923 7327180 YP_002503204.1 CDS MLBr_00733 NC_011896.1 874686 875204 D hypothetical protein 874686..875204 Mycobacterium leprae Br4923 7327265 YP_002503205.1 CDS MLBr_00734 NC_011896.1 875159 875845 R hypothetical protein complement(875159..875845) Mycobacterium leprae Br4923 7326219 YP_002503206.1 CDS purK NC_011896.1 875933 877252 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 875933..877252 Mycobacterium leprae Br4923 7326220 YP_002503207.1 CDS purE NC_011896.1 877252 877767 D phosphoribosylaminoimidazole carboxylase 877252..877767 Mycobacterium leprae Br4923 7325039 YP_002503208.1 CDS fadE25 NC_011896.1 877862 879031 D acyl-CoA dehydrogenase 877862..879031 Mycobacterium leprae Br4923 7325036 YP_002503209.1 CDS ctpC NC_011896.1 888802 890979 R cation transport ATPase complement(888802..890979) Mycobacterium leprae Br4923 7326223 YP_002503210.1 CDS MLBr_00748 NC_011896.1 890990 891268 R hypothetical protein complement(890990..891268) Mycobacterium leprae Br4923 7326138 YP_002503211.1 CDS MLBr_00750 NC_011896.1 892072 893541 R hypothetical protein complement(892072..893541) Mycobacterium leprae Br4923 7326225 YP_002503212.1 CDS rmlD NC_011896.1 893630 894565 D dTDP-rhamnose modification protein 893630..894565 Mycobacterium leprae Br4923 7326226 YP_002503213.1 CDS wbbL NC_011896.1 894558 895484 D dTDP-rhamnosyl transferase 894558..895484 Mycobacterium leprae Br4923 7326631 YP_002503214.1 CDS rmlA2 NC_011896.1 895486 896562 D sugar-phosphate nucleotidyl transferase 895486..896562 Mycobacterium leprae Br4923 7327314 YP_002503215.1 CDS MLBr_00755 NC_011896.1 897502 897762 R hypothetical protein complement(897502..897762) Mycobacterium leprae Br4923 7326227 YP_002503216.1 CDS MLBr_00756 NC_011896.1 897980 899647 R DNA methylase complement(897980..899647) Mycobacterium leprae Br4923 7326228 YP_002503217.1 CDS MLBr_00757 NC_011896.1 899669 900361 R hypothetical protein complement(899669..900361) Mycobacterium leprae Br4923 7326229 YP_002503218.1 CDS MLBr_00758 NC_011896.1 900402 901775 R catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase complement(900402..901775) Mycobacterium leprae Br4923 7326230 YP_002503219.1 CDS MLBr_00759 NC_011896.1 901772 902911 R catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase complement(901772..902911) Mycobacterium leprae Br4923 7326231 YP_002503220.1 CDS whiB2 NC_011896.1 903236 903505 D transcriptional regulator 903236..903505 Mycobacterium leprae Br4923 7326232 YP_002503221.1 CDS MLBr_00761 NC_011896.1 903534 904037 R hypothetical protein complement(903534..904037) Mycobacterium leprae Br4923 7327316 YP_002503222.1 CDS MLBr_00762 NC_011896.1 904077 904574 D hypothetical protein 904077..904574 Mycobacterium leprae Br4923 7326233 YP_002503223.1 CDS manB NC_011896.1 904684 906090 D converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 904684..906090 Mycobacterium leprae Br4923 7326234 YP_002503224.1 CDS MLBr_00764 NC_011896.1 906087 907184 D hypothetical protein 906087..907184 Mycobacterium leprae Br4923 7324973 YP_002503225.1 CDS manA NC_011896.1 907192 908424 D mannose-6-phosphate isomerase 907192..908424 Mycobacterium leprae Br4923 7326235 YP_002503226.1 CDS sahH NC_011896.1 913632 915110 D catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 913632..915110 Mycobacterium leprae Br4923 7326240 YP_002503227.1 CDS tmk NC_011896.1 915153 915785 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 915153..915785 Mycobacterium leprae Br4923 7325965 YP_002503228.1 CDS mtrA NC_011896.1 915878 916564 D two-component response regulator 915878..916564 Mycobacterium leprae Br4923 7326028 YP_002503229.1 CDS mtrB NC_011896.1 916692 918380 D two-component system sensor kinase 916692..918380 Mycobacterium leprae Br4923 7324932 YP_002503230.1 CDS lpqB NC_011896.1 918377 920146 D lipoprotein LpqB 918377..920146 Mycobacterium leprae Br4923 7324933 YP_002503231.1 CDS MLBr_00776 NC_011896.1 920267 920524 D hypothetical protein 920267..920524 Mycobacterium leprae Br4923 7325414 YP_002503232.1 CDS MLBr_00777 NC_011896.1 920664 920858 D hypothetical protein 920664..920858 Mycobacterium leprae Br4923 7326241 YP_002503233.1 CDS MLBr_00778 NC_011896.1 920962 921651 D hypothetical protein 920962..921651 Mycobacterium leprae Br4923 7326242 YP_002503234.1 CDS secA NC_011896.1 921731 924553 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 921731..924553 Mycobacterium leprae Br4923 7326243 YP_002503235.1 CDS MLBr_00781 NC_011896.1 925690 926172 D hypothetical protein 925690..926172 Mycobacterium leprae Br4923 7326244 YP_002503236.1 CDS MLBr_00782 NC_011896.1 926177 927334 D transmembrane transport protein 926177..927334 Mycobacterium leprae Br4923 7326245 YP_002503237.1 CDS MLBr_00791 NC_011896.1 934537 935520 R hypothetical protein complement(934537..935520) Mycobacterium leprae Br4923 7326253 YP_002503238.1 CDS aroA NC_011896.1 935517 936809 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(935517..936809) Mycobacterium leprae Br4923 7326254 YP_002503239.1 CDS MLBr_00793 NC_011896.1 936856 937614 D bacteriophage protein 936856..937614 Mycobacterium leprae Br4923 7327230 YP_002503240.1 CDS MLBr_00796 NC_011896.1 942275 942451 D hypothetical protein 942275..942451 Mycobacterium leprae Br4923 7327254 YP_002503241.1 CDS MLBr_00798 NC_011896.1 946534 948312 R hypothetical protein complement(946534..948312) Mycobacterium leprae Br4923 7324990 YP_002503242.1 CDS MLBr_00799 NC_011896.1 949061 949468 R hypothetical protein complement(949061..949468) Mycobacterium leprae Br4923 7326258 YP_002503243.1 CDS MLBr_00802 NC_011896.1 951834 952073 D acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 951834..952073 Mycobacterium leprae Br4923 7326262 YP_002503244.1 CDS MLBr_00803 NC_011896.1 952123 953625 D two-component system sensor kinase 952123..953625 Mycobacterium leprae Br4923 7326261 YP_002503245.1 CDS whiB1 NC_011896.1 953685 953939 R transcriptional regulator complement(953685..953939) Mycobacterium leprae Br4923 7326263 YP_002503246.1 CDS MLBr_00806 NC_011896.1 955226 955747 D hypothetical protein 955226..955747 Mycobacterium leprae Br4923 7326264 YP_002503247.1 CDS entC NC_011896.1 956175 957908 R isochorismate synthase complement(956175..957908) Mycobacterium leprae Br4923 7326266 YP_002503248.1 CDS MLBr_00810 NC_011896.1 958903 960126 R hypothetical protein complement(958903..960126) Mycobacterium leprae Br4923 7326267 YP_002503249.1 CDS rhlE NC_011896.1 960138 961772 R ATP-dependent RNA helicase complement(960138..961772) Mycobacterium leprae Br4923 7326268 YP_002503250.1 CDS MLBr_00813 NC_011896.1 962728 963315 R hypothetical protein complement(962728..963315) Mycobacterium leprae Br4923 7326269 YP_002503251.1 CDS MLBr_00814 NC_011896.1 963614 963862 D hypothetical protein 963614..963862 Mycobacterium leprae Br4923 7326270 YP_002503252.1 CDS MLBr_00815 NC_011896.1 963849 964535 R TetR family transcriptional regulator complement(963849..964535) Mycobacterium leprae Br4923 7326271 YP_002503253.1 CDS MLBr_00816 NC_011896.1 964722 965747 D hypothetical protein 964722..965747 Mycobacterium leprae Br4923 7326272 YP_002503254.1 CDS moeZ NC_011896.1 965951 967138 D The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 965951..967138 Mycobacterium leprae Br4923 7325050 YP_002503255.1 CDS MLBr_00818 NC_011896.1 967193 968086 D hypothetical protein 967193..968086 Mycobacterium leprae Br4923 7324921 YP_002503256.1 CDS furB NC_011896.1 977825 978220 R ferric uptake regulatory protein complement(977825..978220) Mycobacterium leprae Br4923 7325055 YP_002503257.1 CDS glyS NC_011896.1 978884 980275 D Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 978884..980275 Mycobacterium leprae Br4923 7325056 YP_002503258.1 CDS dgt NC_011896.1 986517 987806 D dGTPase type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 986517..987806 Mycobacterium leprae Br4923 7325059 YP_002503259.1 CDS dnaG NC_011896.1 988501 990429 D synthesizes RNA primers at the replication forks; DNA primase 988501..990429 Mycobacterium leprae Br4923 7325060 YP_002503260.1 CDS MLBr_00834 NC_011896.1 990444 990746 R hypothetical protein complement(990444..990746) Mycobacterium leprae Br4923 7326178 YP_002503261.1 CDS MLBr_00837 NC_011896.1 993925 994308 D hypothetical protein 993925..994308 Mycobacterium leprae Br4923 7325062 YP_002503262.1 CDS cysE NC_011896.1 995713 996396 R serine acetyltransferase complement(995713..996396) Mycobacterium leprae Br4923 7325063 YP_002503263.1 CDS cysK NC_011896.1 996399 997331 R cysteine synthase complement(996399..997331) Mycobacterium leprae Br4923 7326148 YP_002503264.1 CDS MLBr_00840 NC_011896.1 997328 998632 R hypothetical protein complement(997328..998632) Mycobacterium leprae Br4923 7326150 YP_002503265.1 CDS MLBr_00841 NC_011896.1 999015 999938 D major membrane protein I 999015..999938 Mycobacterium leprae Br4923 7325064 YP_002503266.1 CDS MLBr_00842 NC_011896.1 1000594 1001829 D hypothetical protein 1000594..1001829 Mycobacterium leprae Br4923 7325065 YP_002503267.1 CDS narK NC_011896.1 1002602 1004155 D nitrite extrusion protein 1002602..1004155 Mycobacterium leprae Br4923 7325410 YP_002503268.1 CDS MLBr_00845 NC_011896.1 1004143 1004724 R hypothetical protein complement(1004143..1004724) Mycobacterium leprae Br4923 7324956 YP_002503269.1 CDS MLBr_00848 NC_011896.1 1005949 1008123 D ABC transporter 1005949..1008123 Mycobacterium leprae Br4923 7325069 YP_002503270.1 CDS MLBr_00849 NC_011896.1 1008120 1008971 D hypothetical protein 1008120..1008971 Mycobacterium leprae Br4923 7325070 YP_002503271.1 CDS ribF NC_011896.1 1012178 1013173 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1012178..1013173 Mycobacterium leprae Br4923 7325994 YP_002503272.1 CDS rpsO NC_011896.1 1013291 1013560 D primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1013291..1013560 Mycobacterium leprae Br4923 7326622 YP_002503273.1 CDS gpsI NC_011896.1 1013882 1016203 D polynucleotide phosphorylase 1013882..1016203 Mycobacterium leprae Br4923 7325955 YP_002503274.1 CDS pepR NC_011896.1 1016292 1017566 D zinc protease 1016292..1017566 Mycobacterium leprae Br4923 7324656 YP_002503275.1 CDS MLBr_00857 NC_011896.1 1019733 1020485 R hypothetical protein complement(1019733..1020485) Mycobacterium leprae Br4923 7325072 YP_002503276.1 CDS lipA NC_011896.1 1020512 1021456 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(1020512..1021456) Mycobacterium leprae Br4923 7325073 YP_002503277.1 CDS lipB NC_011896.1 1021453 1022160 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(1021453..1022160) Mycobacterium leprae Br4923 7325387 YP_002503278.1 CDS MLBr_00860 NC_011896.1 1022225 1023148 R hypothetical protein complement(1022225..1023148) Mycobacterium leprae Br4923 7325388 YP_002503279.1 CDS MLBr_00861 NC_011896.1 1023164 1024756 R dihydrolipoamide acetyltransferase complement(1023164..1024756) Mycobacterium leprae Br4923 7325074 YP_002503280.1 CDS ephD NC_011896.1 1024996 1026786 D short chain dehydrogenase 1024996..1026786 Mycobacterium leprae Br4923 7325075 YP_002503281.1 CDS MLBr_00863 NC_011896.1 1026944 1027258 D hypothetical protein 1026944..1027258 Mycobacterium leprae Br4923 7325229 YP_002503282.1 CDS pepA NC_011896.1 1027329 1028903 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(1027329..1028903) Mycobacterium leprae Br4923 7325076 YP_002503283.1 CDS gcvT NC_011896.1 1029064 1030167 D catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 1029064..1030167 Mycobacterium leprae Br4923 7327372 YP_002503284.1 CDS ilvE NC_011896.1 1030224 1031330 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1030224..1031330 Mycobacterium leprae Br4923 7325338 YP_002503285.1 CDS cobT NC_011896.1 1032099 1033154 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(1032099..1033154) Mycobacterium leprae Br4923 7326124 YP_002503286.1 CDS MLBr_00869 NC_011896.1 1033244 1033618 R hypothetical protein complement(1033244..1033618) Mycobacterium leprae Br4923 7326125 YP_002503287.1 CDS MLBr_00871 NC_011896.1 1035267 1035623 D hypothetical protein 1035267..1035623 Mycobacterium leprae Br4923 7325078 YP_002503288.1 CDS MLBr_00872 NC_011896.1 1035658 1036173 R hypothetical protein complement(1035658..1036173) Mycobacterium leprae Br4923 7325079 YP_002503289.1 CDS MLBr_00873 NC_011896.1 1036492 1037466 D carbohydrate kinase 1036492..1037466 Mycobacterium leprae Br4923 7325080 YP_002503290.1 CDS asnB NC_011896.1 1037649 1039682 R asparagine synthetase complement(1037649..1039682) Mycobacterium leprae Br4923 7325081 YP_002503291.1 CDS ctaC NC_011896.1 1039825 1040886 D cytochrome C oxidase chain II 1039825..1040886 Mycobacterium leprae Br4923 7327241 YP_002503292.1 CDS MLBr_00876 NC_011896.1 1040939 1041358 D hypothetical protein 1040939..1041358 Mycobacterium leprae Br4923 7326134 YP_002503293.1 CDS mmpS3 NC_011896.1 1041545 1042426 D hypothetical protein 1041545..1042426 Mycobacterium leprae Br4923 7325082 YP_002503294.1 CDS MLBr_00878 NC_011896.1 1042426 1043064 D hypothetical protein 1042426..1043064 Mycobacterium leprae Br4923 7324908 YP_002503295.1 CDS qcrB NC_011896.1 1043198 1044853 R cytochrome B complement(1043198..1044853) Mycobacterium leprae Br4923 7325083 YP_002503296.1 CDS qcrA NC_011896.1 1044850 1046034 R Rieske iron-sulfur reductase subunit complement(1044850..1046034) Mycobacterium leprae Br4923 7326604 YP_002503297.1 CDS qcrC NC_011896.1 1046031 1046900 R cytochrome C reductase cytochrome C component complement(1046031..1046900) Mycobacterium leprae Br4923 7326603 YP_002503298.1 CDS ctaE NC_011896.1 1046962 1047570 R cytochrome C oxidase subunit III complement(1046962..1047570) Mycobacterium leprae Br4923 7326605 YP_002503299.1 CDS trpD NC_011896.1 1047707 1048807 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1047707..1048807 Mycobacterium leprae Br4923 7326135 YP_002503300.1 CDS MLBr_00885 NC_011896.1 1051006 1052130 D hypothetical protein 1051006..1052130 Mycobacterium leprae Br4923 7325084 YP_002503301.1 CDS MLBr_00886 NC_011896.1 1052175 1053329 D glycosyl transferase family protein 1052175..1053329 Mycobacterium leprae Br4923 7325085 YP_002503302.1 CDS MLBr_00887 NC_011896.1 1053326 1055128 R long-chain-fatty-acid-CoA ligase complement(1053326..1055128) Mycobacterium leprae Br4923 7325086 YP_002503303.1 CDS MLBr_00888 NC_011896.1 1055303 1055710 D hypothetical protein 1055303..1055710 Mycobacterium leprae Br4923 7325087 YP_002503304.1 CDS MLBr_00889 NC_011896.1 1055829 1056263 D hypothetical protein 1055829..1056263 Mycobacterium leprae Br4923 7325088 YP_002503305.1 CDS MLBr_00890 NC_011896.1 1056284 1057531 D membrane transport ATPase 1056284..1057531 Mycobacterium leprae Br4923 7325089 YP_002503306.1 CDS MLBr_00891 NC_011896.1 1057528 1057920 D hypothetical protein 1057528..1057920 Mycobacterium leprae Br4923 7325090 YP_002503307.1 CDS MLBr_00892 NC_011896.1 1058006 1058740 D acyltransferase 1058006..1058740 Mycobacterium leprae Br4923 7325091 YP_002503308.1 CDS MLBr_00893 NC_011896.1 1058748 1060034 R hypothetical protein complement(1058748..1060034) Mycobacterium leprae Br4923 7325092 YP_002503309.1 CDS MLBr_00895 NC_011896.1 1061051 1061566 D hypothetical protein 1061051..1061566 Mycobacterium leprae Br4923 7325094 YP_002503310.1 CDS aroG NC_011896.1 1061630 1063018 D 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase 1061630..1063018 Mycobacterium leprae Br4923 7325095 YP_002503311.1 CDS MLBr_00897 NC_011896.1 1063031 1064233 R serine-threonine protein kinase complement(1063031..1064233) Mycobacterium leprae Br4923 7327235 YP_002503312.1 CDS MLBr_00898 NC_011896.1 1064386 1064790 D DNA-binding protein 1064386..1064790 Mycobacterium leprae Br4923 7325096 YP_002503313.1 CDS MLBr_00899 NC_011896.1 1064787 1066304 R integral-membrane protein complement(1064787..1066304) Mycobacterium leprae Br4923 7325097 YP_002503314.1 CDS MLBr_00901 NC_011896.1 1067643 1068557 D hypothetical protein 1067643..1068557 Mycobacterium leprae Br4923 7324705 YP_002503315.1 CDS MLBr_00902 NC_011896.1 1068554 1069273 R lipoprotein complement(1068554..1069273) Mycobacterium leprae Br4923 7325099 YP_002503316.1 CDS MLBr_00903 NC_011896.1 1069345 1069977 R hypothetical protein complement(1069345..1069977) Mycobacterium leprae Br4923 7325100 YP_002503317.1 CDS MLBr_00904 NC_011896.1 1070294 1070698 D hypothetical protein 1070294..1070698 Mycobacterium leprae Br4923 7325101 YP_002503318.1 CDS MLBr_00905 NC_011896.1 1071071 1071502 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1071071..1071502 Mycobacterium leprae Br4923 7325102 YP_002503319.1 CDS mraW NC_011896.1 1071630 1072748 D S-adenosyl-methyltransferase MraW 1071630..1072748 Mycobacterium leprae Br4923 7325103 YP_002503320.1 CDS MLBr_00907 NC_011896.1 1072745 1073878 D hypothetical protein 1072745..1073878 Mycobacterium leprae Br4923 7325104 YP_002503321.1 CDS pbpB NC_011896.1 1073875 1075902 D penicillin-binding protein 2 1073875..1075902 Mycobacterium leprae Br4923 7325105 YP_002503322.1 CDS murE NC_011896.1 1076044 1077636 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1076044..1077636 Mycobacterium leprae Br4923 7327355 YP_002503323.1 CDS murF NC_011896.1 1077633 1079186 D UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase (D-alanine:D-alanine-adding enzyme) 1077633..1079186 Mycobacterium leprae Br4923 7324938 YP_002503324.1 CDS mraY NC_011896.1 1079183 1080262 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1079183..1080262 Mycobacterium leprae Br4923 7324939 YP_002503325.1 CDS murD NC_011896.1 1080264 1081736 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1080264..1081736 Mycobacterium leprae Br4923 7324927 YP_002503326.1 CDS ftsW NC_011896.1 1081743 1083347 D cell division protein FtsW 1081743..1083347 Mycobacterium leprae Br4923 7324937 YP_002503327.1 CDS murG NC_011896.1 1083344 1084567 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 1083344..1084567 Mycobacterium leprae Br4923 7325315 YP_002503328.1 CDS murC NC_011896.1 1084564 1086051 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1084564..1086051 Mycobacterium leprae Br4923 7324940 YP_002503329.1 CDS MLBr_00916 NC_011896.1 1086048 1087073 D FtsQ-family protein 1086048..1087073 Mycobacterium leprae Br4923 7324936 YP_002503330.1 CDS ftsZ NC_011896.1 1087339 1088478 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1087339..1088478 Mycobacterium leprae Br4923 7325106 YP_002503331.1 CDS MLBr_00918 NC_011896.1 1088501 1089250 D hypothetical protein 1088501..1089250 Mycobacterium leprae Br4923 7325317 YP_002503332.1 CDS MLBr_00919 NC_011896.1 1089247 1090029 D DNA-binding protein 1089247..1090029 Mycobacterium leprae Br4923 7325107 YP_002503333.1 CDS MLBr_00920 NC_011896.1 1090097 1090729 D hypothetical protein 1090097..1090729 Mycobacterium leprae Br4923 7325108 YP_002503334.1 CDS MLBr_00921 NC_011896.1 1090854 1091144 D hypothetical protein 1090854..1091144 Mycobacterium leprae Br4923 7325109 YP_002503335.1 CDS ag84 NC_011896.1 1091391 1092191 D hypothetical protein 1091391..1092191 Mycobacterium leprae Br4923 7325110 YP_002503336.1 CDS MLBr_00923 NC_011896.1 1092264 1092656 D hypothetical protein 1092264..1092656 Mycobacterium leprae Br4923 7327194 YP_002503337.1 CDS glnA NC_011896.1 1094419 1095855 D glutamine synthase class I 1094419..1095855 Mycobacterium leprae Br4923 7325112 YP_002503338.1 CDS MLBr_00926 NC_011896.1 1096107 1096475 R hypothetical protein complement(1096107..1096475) Mycobacterium leprae Br4923 7325349 YP_002503339.1 CDS MLBr_00927 NC_011896.1 1096567 1096875 R hypothetical protein complement(1096567..1096875) Mycobacterium leprae Br4923 7325113 YP_002503340.1 CDS MLBr_00928 NC_011896.1 1098096 1098380 D hypothetical protein 1098096..1098380 Mycobacterium leprae Br4923 7325114 YP_002503341.1 CDS MLBr_00938 NC_011896.1 1109935 1110231 D hypothetical protein 1109935..1110231 Mycobacterium leprae Br4923 7325123 YP_002503342.1 CDS MLBr_00939 NC_011896.1 1110228 1110470 D hypothetical protein 1110228..1110470 Mycobacterium leprae Br4923 7325124 YP_002503343.1 CDS MLBr_00946 NC_011896.1 1116273 1116650 D hypothetical protein 1116273..1116650 Mycobacterium leprae Br4923 7325129 YP_002503344.1 CDS MLBr_00947 NC_011896.1 1117561 1117818 R hypothetical protein complement(1117561..1117818) Mycobacterium leprae Br4923 7325130 YP_002503345.1 CDS MLBr_00949 NC_011896.1 1118771 1119184 R hypothetical protein complement(1118771..1119184) Mycobacterium leprae Br4923 7326685 YP_002503346.1 CDS MLBr_00950 NC_011896.1 1119196 1119396 R hypothetical protein complement(1119196..1119396) Mycobacterium leprae Br4923 7326686 YP_002503347.1 CDS MLBr_00953 NC_011896.1 1121934 1122173 D hypothetical protein 1121934..1122173 Mycobacterium leprae Br4923 7326689 YP_002503348.1 CDS ppdK NC_011896.1 1123058 1124863 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase complement(1123058..1124863) Mycobacterium leprae Br4923 7326691 YP_002503349.1 CDS MLBr_00956 NC_011896.1 1124908 1125417 D integral membrane protein 1124908..1125417 Mycobacterium leprae Br4923 7324985 YP_002503350.1 CDS MLBr_00957 NC_011896.1 1125895 1126269 R hypothetical protein complement(1125895..1126269) Mycobacterium leprae Br4923 7326692 YP_002503351.1 CDS MLBr_00958 NC_011896.1 1126280 1126711 D hypothetical protein 1126280..1126711 Mycobacterium leprae Br4923 7326693 YP_002503352.1 CDS MLBr_00959 NC_011896.1 1126953 1127306 D hypothetical protein 1126953..1127306 Mycobacterium leprae Br4923 7326694 YP_002503353.1 CDS metE NC_011896.1 1127818 1130100 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase complement(1127818..1130100) Mycobacterium leprae Br4923 7326696 YP_002503354.1 CDS MLBr_00963 NC_011896.1 1131339 1131803 D hypothetical protein 1131339..1131803 Mycobacterium leprae Br4923 7326697 YP_002503355.1 CDS MLBr_00964 NC_011896.1 1131841 1132098 D hypothetical protein 1131841..1132098 Mycobacterium leprae Br4923 7326698 YP_002503356.1 CDS ftsK NC_011896.1 1144536 1147196 D Cell division protein 1144536..1147196 Mycobacterium leprae Br4923 7326711 YP_002503357.1 CDS MLBr_00978 NC_011896.1 1147206 1147748 R catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase complement(1147206..1147748) Mycobacterium leprae Br4923 7325314 YP_002503358.1 CDS MLBr_00979 NC_011896.1 1147815 1148396 D CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1147815..1148396 Mycobacterium leprae Br4923 7326712 YP_002503359.1 CDS MLBr_00984 NC_011896.1 1151064 >1151513 R hypothetical protein complement(1151064..>1151513) Mycobacterium leprae Br4923 7326717 YP_002503360.1 CDS MLBr_00985 NC_011896.1 1151550 1152728 D glycosyltransferase 1151550..1152728 Mycobacterium leprae Br4923 7326718 YP_002503361.1 CDS MLBr_00986 NC_011896.1 1152742 1152945 D hypothetical protein 1152742..1152945 Mycobacterium leprae Br4923 7326719 YP_002503362.1 CDS recA NC_011896.1 1153096 1155231 D recombinase A 1153096..1155231 Mycobacterium leprae Br4923 7326720 YP_002503363.1 CDS recX NC_011896.1 1155197 1155712 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1155197..1155712 Mycobacterium leprae Br4923 7326609 YP_002503364.1 CDS MLBr_00989 NC_011896.1 1155771 1157324 D catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1155771..1157324 Mycobacterium leprae Br4923 7326614 YP_002503365.1 CDS MLBr_00990 NC_011896.1 1157321 1157950 D hypothetical protein 1157321..1157950 Mycobacterium leprae Br4923 7326721 YP_002503366.1 CDS MLBr_00994 NC_011896.1 1162660 1163358 D hypothetical protein 1162660..1163358 Mycobacterium leprae Br4923 7326725 YP_002503367.1 CDS miaA NC_011896.1 1163355 1164290 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1163355..1164290 Mycobacterium leprae Br4923 7326726 YP_002503368.1 CDS dapF NC_011896.1 1164357 1165247 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1164357..1165247 Mycobacterium leprae Br4923 7324901 YP_002503369.1 CDS MLBr_00997 NC_011896.1 1165310 1166776 D ATP/GTP-binding protein 1165310..1166776 Mycobacterium leprae Br4923 7326161 YP_002503370.1 CDS MLBr_01001 NC_011896.1 1172639 1172914 R hypothetical protein complement(1172639..1172914) Mycobacterium leprae Br4923 7326730 YP_002503371.1 CDS MLBr_01002 NC_011896.1 1172959 1175022 D hypothetical protein 1172959..1175022 Mycobacterium leprae Br4923 7326731 YP_002503372.1 CDS lexA NC_011896.1 1175061 1175768 R Represses a number of genes involved in the response to DNA damage; LexA repressor complement(1175061..1175768) Mycobacterium leprae Br4923 7326732 YP_002503373.1 CDS MLBr_01004 NC_011896.1 1176048 1176542 D hypothetical protein 1176048..1176542 Mycobacterium leprae Br4923 7325383 YP_002503374.1 CDS nrdR NC_011896.1 1176704 1177168 D transcriptional regulator NrdR 1176704..1177168 Mycobacterium leprae Br4923 7326733 YP_002503375.1 CDS MLBr_01006 NC_011896.1 1177210 1177695 D hypothetical protein 1177210..1177695 Mycobacterium leprae Br4923 7326734 YP_002503376.1 CDS MLBr_01009 NC_011896.1 1179559 1180539 R hypothetical protein complement(1179559..1180539) Mycobacterium leprae Br4923 7326737 YP_002503377.1 CDS MLBr_01010 NC_011896.1 1180816 1181058 R hypothetical protein complement(1180816..1181058) Mycobacterium leprae Br4923 7326738 YP_002503378.1 CDS MLBr_01011 NC_011896.1 1181098 1181520 R hypothetical protein complement(1181098..1181520) Mycobacterium leprae Br4923 7326739 YP_002503379.1 CDS MLBr_01013 NC_011896.1 1183521 1184213 R iron dependent repressor complement(1183521..1184213) Mycobacterium leprae Br4923 7326741 YP_002503380.1 CDS MLBr_01014 NC_011896.1 1184370 1185329 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB complement(1184370..1185329) Mycobacterium leprae Br4923 7326742 YP_002503381.1 CDS MLBr_01015 NC_011896.1 1185496 1185915 R hypothetical protein complement(1185496..1185915) Mycobacterium leprae Br4923 7326743 YP_002503382.1 CDS MLBr_01016 NC_011896.1 1185943 1186266 D hypothetical protein 1185943..1186266 Mycobacterium leprae Br4923 7326744 YP_002503383.1 CDS MLBr_01017 NC_011896.1 1186253 1187245 R hypothetical protein complement(1186253..1187245) Mycobacterium leprae Br4923 7326745 YP_002503384.1 CDS MLBr_01018 NC_011896.1 1187250 1187465 R hypothetical protein complement(1187250..1187465) Mycobacterium leprae Br4923 7326746 YP_002503385.1 CDS rpoT NC_011896.1 1189225 1190949 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor complement(1189225..1190949) Mycobacterium leprae Br4923 7326750 YP_002503386.1 CDS ppgK NC_011896.1 1190960 1191934 R polyphosphate glucokinase complement(1190960..1191934) Mycobacterium leprae Br4923 7326676 YP_002503387.1 CDS suhB NC_011896.1 1191883 1192758 D inositol monophosphatase 1191883..1192758 Mycobacterium leprae Br4923 7324999 YP_002503388.1 CDS MLBr_01025 NC_011896.1 1192762 1193412 R hypothetical protein complement(1192762..1193412) Mycobacterium leprae Br4923 7326008 YP_002503389.1 CDS MLBr_01026 NC_011896.1 1193608 1193910 D hypothetical protein 1193608..1193910 Mycobacterium leprae Br4923 7326751 YP_002503390.1 CDS MLBr_01027 NC_011896.1 1193915 1194388 R hypothetical protein complement(1193915..1194388) Mycobacterium leprae Br4923 7326752 YP_002503391.1 CDS dut NC_011896.1 1194414 1194878 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1194414..1194878 Mycobacterium leprae Br4923 7326753 YP_002503392.1 CDS MLBr_01029 NC_011896.1 1194875 1195696 D hypothetical protein 1194875..1195696 Mycobacterium leprae Br4923 7326188 YP_002503393.1 CDS MLBr_01030 NC_011896.1 1195741 1196439 R hypothetical protein complement(1195741..1196439) Mycobacterium leprae Br4923 7326754 YP_002503394.1 CDS MLBr_01036 NC_011896.1 1199277 1200566 R membrane transport protein complement(1199277..1200566) Mycobacterium leprae Br4923 7326760 YP_002503395.1 CDS MLBr_01037 NC_011896.1 1200619 1201173 R hypothetical protein complement(1200619..1201173) Mycobacterium leprae Br4923 7326761 YP_002503396.1 CDS dxs NC_011896.1 1201255 1203186 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1201255..1203186 Mycobacterium leprae Br4923 7326762 YP_002503397.1 CDS MLBr_01040 NC_011896.1 1205287 1206576 R hypothetical protein complement(1205287..1206576) Mycobacterium leprae Br4923 7326763 YP_002503398.1 CDS MLBr_01041 NC_011896.1 1206578 1207168 R hypothetical protein complement(1206578..1207168) Mycobacterium leprae Br4923 7326764 YP_002503399.1 CDS hemE NC_011896.1 1208257 1209330 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1208257..1209330 Mycobacterium leprae Br4923 7326521 YP_002503400.1 CDS hemY NC_011896.1 1209327 1210682 D catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 1209327..1210682 Mycobacterium leprae Br4923 7324674 YP_002503401.1 CDS MLBr_01045 NC_011896.1 1210688 1211383 D hypothetical protein 1210688..1211383 Mycobacterium leprae Br4923 7324676 YP_002503402.1 CDS xclC NC_011896.1 1217149 1218579 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1217149..1218579 Mycobacterium leprae Br4923 7326527 YP_002503403.1 CDS MLBr_01052 NC_011896.1 1218602 1219867 R hypothetical protein complement(1218602..1219867) Mycobacterium leprae Br4923 7327319 YP_002503404.1 CDS MLBr_01053 NC_011896.1 1220414 1220713 D hypothetical protein 1220414..1220713 Mycobacterium leprae Br4923 7326528 YP_002503405.1 CDS MLBr_01055 NC_011896.1 1221473 1221775 D hypothetical protein 1221473..1221775 Mycobacterium leprae Br4923 7326530 YP_002503406.1 CDS MLBr_01056 NC_011896.1 1221827 1222114 D hypothetical protein 1221827..1222114 Mycobacterium leprae Br4923 7326531 YP_002503407.1 CDS MLBr_01057 NC_011896.1 1222289 1222642 D hypothetical protein 1222289..1222642 Mycobacterium leprae Br4923 7326532 YP_002503408.1 CDS MLBr_01058 NC_011896.1 1222733 1223686 R transferase complement(1222733..1223686) Mycobacterium leprae Br4923 7326533 YP_002503409.1 CDS dapE NC_011896.1 1223740 1224804 D catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1223740..1224804 Mycobacterium leprae Br4923 7326534 YP_002503410.1 CDS MLBr_01061 NC_011896.1 1226482 1227045 D hypothetical protein 1226482..1227045 Mycobacterium leprae Br4923 7326535 YP_002503411.1 CDS folP2 NC_011896.1 1228816 1229691 D dihydropteroate synthase 1228816..1229691 Mycobacterium leprae Br4923 7325260 YP_002503412.1 CDS MLBr_01064 NC_011896.1 1229688 1230668 D glucosyl-3-phosphoglycerate synthase 1229688..1230668 Mycobacterium leprae Br4923 7325307 YP_002503413.1 CDS MLBr_01065 NC_011896.1 1230684 1231028 D hypothetical protein 1230684..1231028 Mycobacterium leprae Br4923 7326537 YP_002503414.1 CDS tagA NC_011896.1 1231025 1231603 D DNA-3-methyladenine glycosidase I 1231025..1231603 Mycobacterium leprae Br4923 7326538 YP_002503415.1 CDS MLBr_01067 NC_011896.1 1231817 1232044 D hypothetical protein 1231817..1232044 Mycobacterium leprae Br4923 7326009 YP_002503416.1 CDS glgC NC_011896.1 1233389 1234603 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1233389..1234603 Mycobacterium leprae Br4923 7326540 YP_002503417.1 CDS MLBr_01070 NC_011896.1 1234677 1235330 D TetR family transcriptional regulator 1234677..1235330 Mycobacterium leprae Br4923 7325344 YP_002503418.1 CDS MLBr_01075 NC_011896.1 1238426 1239100 R O-methyltransferase complement(1238426..1239100) Mycobacterium leprae Br4923 7326545 YP_002503419.1 CDS sigE NC_011896.1 1239380 1240171 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1239380..1240171 Mycobacterium leprae Br4923 7326546 YP_002503420.1 CDS MLBr_01077 NC_011896.1 1240318 1240737 D hypothetical protein 1240318..1240737 Mycobacterium leprae Br4923 7325987 YP_002503421.1 CDS htrA NC_011896.1 1240812 1242413 D serine protease 1240812..1242413 Mycobacterium leprae Br4923 7326547 YP_002503422.1 CDS MLBr_01079 NC_011896.1 1242413 1242775 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1242413..1242775 Mycobacterium leprae Br4923 7324701 YP_002503423.1 CDS mrp NC_011896.1 1243795 1244946 R MRP-family ATP-binding protein complement(1243795..1244946) Mycobacterium leprae Br4923 7326548 YP_002503424.1 CDS MLBr_01086 NC_011896.1 1248365 1249771 D solute-binding transport lipoprotein 1248365..1249771 Mycobacterium leprae Br4923 7326553 YP_002503425.1 CDS MLBr_01087 NC_011896.1 1249800 1250714 D ABC transporter inner membrane protein 1249800..1250714 Mycobacterium leprae Br4923 7326554 YP_002503426.1 CDS MLBr_01088 NC_011896.1 1250704 1251567 D ABC transporter inner membrane protein 1250704..1251567 Mycobacterium leprae Br4923 7326555 YP_002503427.1 CDS MLBr_01089 NC_011896.1 1251572 1252750 D ABC transporter ATP-binding protein 1251572..1252750 Mycobacterium leprae Br4923 7326556 YP_002503428.1 CDS MLBr_01090 NC_011896.1 1253379 1254488 R membrane transport protein complement(1253379..1254488) Mycobacterium leprae Br4923 7326557 YP_002503429.1 CDS mdh NC_011896.1 1254711 1255700 D catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1254711..1255700 Mycobacterium leprae Br4923 7326558 YP_002503430.1 CDS MLBr_01093 NC_011896.1 1257769 1258626 D lipoprotein 1257769..1258626 Mycobacterium leprae Br4923 7326559 YP_002503431.1 CDS MLBr_01094 NC_011896.1 1259172 1260005 R short chain alcohol dehydrogenase complement(1259172..1260005) Mycobacterium leprae Br4923 7326560 YP_002503432.1 CDS kgd NC_011896.1 1260068 1263850 R kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase complement(1260068..1263850) Mycobacterium leprae Br4923 7326561 YP_002503433.1 CDS MLBr_01096 NC_011896.1 1263972 1264646 R hypothetical protein complement(1263972..1264646) Mycobacterium leprae Br4923 7327337 YP_002503434.1 CDS MLBr_01098 NC_011896.1 1266688 1270146 R hypothetical protein complement(1266688..1270146) Mycobacterium leprae Br4923 7326563 YP_002503435.1 CDS MLBr_01099 NC_011896.1 1270197 1270805 R lipoprotein complement(1270197..1270805) Mycobacterium leprae Br4923 7326564 YP_002503436.1 CDS MLBr_01101 NC_011896.1 1272672 1273811 D acyltransferase 1272672..1273811 Mycobacterium leprae Br4923 7326566 YP_002503437.1 CDS MLBr_01103 NC_011896.1 1276498 1277859 R oxidoreductase subunit complement(1276498..1277859) Mycobacterium leprae Br4923 7326568 YP_002503438.1 CDS MLBr_01105 NC_011896.1 1279302 1279991 D hypothetical protein 1279302..1279991 Mycobacterium leprae Br4923 7326570 YP_002503439.1 CDS MLBr_01106 NC_011896.1 1280466 1280807 D hypothetical protein 1280466..1280807 Mycobacterium leprae Br4923 7326571 YP_002503440.1 CDS MLBr_01113 NC_011896.1 1287777 1289666 R ABC transporter ATP-binding protein complement(1287777..1289666) Mycobacterium leprae Br4923 7326578 YP_002503441.1 CDS MLBr_01114 NC_011896.1 1289663 1291417 R ABC transporter protein, ATP-binding component complement(1289663..1291417) Mycobacterium leprae Br4923 7326579 YP_002503442.1 CDS MLBr_01115 NC_011896.1 1291603 1292169 D lipoprotein 1291603..1292169 Mycobacterium leprae Br4923 7326580 YP_002503443.1 CDS MLBr_01116 NC_011896.1 1292178 1292741 D lipoprotein 1292178..1292741 Mycobacterium leprae Br4923 7326581 YP_002503444.1 CDS MLBr_01117 NC_011896.1 1292749 1293234 R hypothetical protein complement(1292749..1293234) Mycobacterium leprae Br4923 7326582 YP_002503445.1 CDS MLBr_01119 NC_011896.1 1294803 1295954 D hypothetical protein 1294803..1295954 Mycobacterium leprae Br4923 7326584 YP_002503446.1 CDS MLBr_01120 NC_011896.1 1295951 1298572 D hypothetical protein 1295951..1298572 Mycobacterium leprae Br4923 7326585 YP_002503447.1 CDS MLBr_01121 NC_011896.1 1299760 1301433 R extracellular solute-binding dependent transport lipoprotein complement(1299760..1301433) Mycobacterium leprae Br4923 7326586 YP_002503448.1 CDS MLBr_01122 NC_011896.1 1301430 1303259 R ABC transporter ATP-binding protein complement(1301430..1303259) Mycobacterium leprae Br4923 7326587 YP_002503449.1 CDS MLBr_01123 NC_011896.1 1303256 1304155 R binding-protein dependent transport protein complement(1303256..1304155) Mycobacterium leprae Br4923 7326588 YP_002503450.1 CDS MLBr_01124 NC_011896.1 1304152 1305129 R binding-protein dependent transport protein complement(1304152..1305129) Mycobacterium leprae Br4923 7326589 YP_002503451.1 CDS argS NC_011896.1 1316611 1318263 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1316611..1318263 Mycobacterium leprae Br4923 7327228 YP_002503452.1 CDS lysA NC_011896.1 1318260 1319678 D diaminopimelate decarboxylase 1318260..1319678 Mycobacterium leprae Br4923 7327225 YP_002503453.1 CDS hom NC_011896.1 1319682 1321007 D catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1319682..1321007 Mycobacterium leprae Br4923 7325429 YP_002503454.1 CDS thrC NC_011896.1 1321004 1322086 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1321004..1322086 Mycobacterium leprae Br4923 7324691 YP_002503455.1 CDS thrB NC_011896.1 1322154 1323101 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1322154..1323101 Mycobacterium leprae Br4923 7326020 YP_002503456.1 CDS rho NC_011896.1 1323371 1325203 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1323371..1325203 Mycobacterium leprae Br4923 7326019 YP_002503457.1 CDS rpmE NC_011896.1 1325514 1325768 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1325514..1325768 Mycobacterium leprae Br4923 7326619 YP_002503458.1 CDS prfA NC_011896.1 1325859 1326944 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1325859..1326944 Mycobacterium leprae Br4923 7326668 YP_002503459.1 CDS MLBr_01135 NC_011896.1 1326941 1327807 D protoporphyrinogen oxidase 1326941..1327807 Mycobacterium leprae Br4923 7325005 YP_002503460.1 CDS MLBr_01136 NC_011896.1 1327847 1328509 D hypothetical protein 1327847..1328509 Mycobacterium leprae Br4923 7326593 YP_002503461.1 CDS MLBr_01137 NC_011896.1 1328540 1329739 D glycosyltransferase 1328540..1329739 Mycobacterium leprae Br4923 7326594 YP_002503462.1 CDS MLBr_01138 NC_011896.1 1330002 1330463 D integral membrane protein 1330002..1330463 Mycobacterium leprae Br4923 7326595 YP_002503463.1 CDS atpB NC_011896.1 1330460 1331215 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1330460..1331215 Mycobacterium leprae Br4923 7326596 YP_002503464.1 CDS atpE NC_011896.1 1331311 1331556 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1331311..1331556 Mycobacterium leprae Br4923 7327246 YP_002503465.1 CDS atpF NC_011896.1 1331578 1332090 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1331578..1332090 Mycobacterium leprae Br4923 7327249 YP_002503466.1 CDS atpH NC_011896.1 1332096 1333436 D produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1332096..1333436 Mycobacterium leprae Br4923 7327250 YP_002503467.1 CDS atpA NC_011896.1 1333498 1335174 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1333498..1335174 Mycobacterium leprae Br4923 7327252 YP_002503468.1 CDS atpG NC_011896.1 1335192 1336088 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1335192..1336088 Mycobacterium leprae Br4923 7327245 YP_002503469.1 CDS atpD NC_011896.1 1336115 1337572 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1336115..1337572 Mycobacterium leprae Br4923 7327251 YP_002503470.1 CDS atpC NC_011896.1 1337605 1337970 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1337605..1337970 Mycobacterium leprae Br4923 7327248 YP_002503471.1 CDS MLBr_01147 NC_011896.1 1337977 1338420 D hypothetical protein 1337977..1338420 Mycobacterium leprae Br4923 7327247 YP_002503472.1 CDS MLBr_01148 NC_011896.1 1338559 1338714 R hypothetical protein complement(1338559..1338714) Mycobacterium leprae Br4923 7326597 YP_002503473.1 CDS MLBr_01149 NC_011896.1 1338927 1339502 R hypothetical protein complement(1338927..1339502) Mycobacterium leprae Br4923 7326598 YP_002503474.1 CDS murA NC_011896.1 1339620 1340876 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1339620..1340876 Mycobacterium leprae Br4923 7326599 YP_002503475.1 CDS ogt NC_011896.1 1346400 1346897 R methylated-DNA--protein-cysteine methyltransferase complement(1346400..1346897) Mycobacterium leprae Br4923 7324934 YP_002503476.1 CDS MLBr_01155 NC_011896.1 1351399 1352061 D hypothetical protein 1351399..1352061 Mycobacterium leprae Br4923 7326601 YP_002503477.1 CDS MLBr_01157 NC_011896.1 1352393 1352860 R hypothetical protein complement(1352393..1352860) Mycobacterium leprae Br4923 7327034 YP_002503478.1 CDS fadA4 NC_011896.1 1352952 1354133 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1352952..1354133 Mycobacterium leprae Br4923 7327035 YP_002503479.1 CDS MLBr_01159 NC_011896.1 1354320 1355225 D hypothetical protein 1354320..1355225 Mycobacterium leprae Br4923 7325239 YP_002503480.1 CDS clpS NC_011896.1 1364652 1364978 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1364652..1364978 Mycobacterium leprae Br4923 7327041 YP_002503481.1 CDS MLBr_01166 NC_011896.1 1365004 1365591 D hypothetical protein 1365004..1365591 Mycobacterium leprae Br4923 7327042 YP_002503482.1 CDS MLBr_01167 NC_011896.1 1365591 1366679 D hydrolase 1365591..1366679 Mycobacterium leprae Br4923 7327043 YP_002503483.1 CDS MLBr_01171 NC_011896.1 1368532 1369248 D hypothetical protein 1368532..1369248 Mycobacterium leprae Br4923 7326151 YP_002503484.1 CDS murI NC_011896.1 1369245 1370063 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1369245..1370063 Mycobacterium leprae Br4923 7327047 YP_002503485.1 CDS MLBr_01173 NC_011896.1 1370136 1370918 D hypothetical protein 1370136..1370918 Mycobacterium leprae Br4923 7324941 YP_002503486.1 CDS rph NC_011896.1 1371008 1371787 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1371008..1371787 Mycobacterium leprae Br4923 7327048 YP_002503487.1 CDS MLBr_01175 NC_011896.1 1371822 1372484 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1371822..1372484 Mycobacterium leprae Br4923 7326640 YP_002503488.1 CDS MLBr_01176 NC_011896.1 1372525 1372884 R hypothetical protein complement(1372525..1372884) Mycobacterium leprae Br4923 7327049 YP_002503489.1 CDS MLBr_01177 NC_011896.1 1372881 1373261 R lipoprotein complement(1372881..1373261) Mycobacterium leprae Br4923 7327050 YP_002503490.1 CDS MLBr_01180 NC_011896.1 1380340 1380627 R hypothetical protein complement(1380340..1380627) Mycobacterium leprae Br4923 7327053 YP_002503491.1 CDS MLBr_01181 NC_011896.1 1380679 1380981 R hypothetical protein complement(1380679..1380981) Mycobacterium leprae Br4923 7327054 YP_002503492.1 CDS MLBr_01182 NC_011896.1 1381044 1382297 R PPE family protein complement(1381044..1382297) Mycobacterium leprae Br4923 7327055 YP_002503493.1 CDS MLBr_01183 NC_011896.1 1382354 1382653 R hypothetical protein complement(1382354..1382653) Mycobacterium leprae Br4923 7327056 YP_002503494.1 CDS MLBr_01186 NC_011896.1 1386804 1387106 R hypothetical protein complement(1386804..1387106) Mycobacterium leprae Br4923 7327059 YP_002503495.1 CDS MLBr_01188 NC_011896.1 1390623 1390883 R hypothetical protein complement(1390623..1390883) Mycobacterium leprae Br4923 7327061 YP_002503496.1 CDS MLBr_01189 NC_011896.1 1392521 1392904 R hypothetical protein complement(1392521..1392904) Mycobacterium leprae Br4923 7327062 YP_002503497.1 CDS MLBr_01190 NC_011896.1 1395319 1396038 D hypothetical protein 1395319..1396038 Mycobacterium leprae Br4923 7327063 YP_002503498.1 CDS fas NC_011896.1 1396650 1405880 D fatty acid synthase 1396650..1405880 Mycobacterium leprae Br4923 7327064 YP_002503499.1 CDS acpS NC_011896.1 1405909 1406301 D Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1405909..1406301 Mycobacterium leprae Br4923 7325286 YP_002503500.1 CDS MLBr_01193 NC_011896.1 1406391 1407719 D hypothetical protein 1406391..1407719 Mycobacterium leprae Br4923 7327186 YP_002503501.1 CDS ileS NC_011896.1 1410813 1413992 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1410813..1413992 Mycobacterium leprae Br4923 7327066 YP_002503502.1 CDS ansA NC_011896.1 1416049 1416981 R L-asparaginase/L-glutaminase complement(1416049..1416981) Mycobacterium leprae Br4923 7326173 YP_002503503.1 CDS lspA NC_011896.1 1417056 1417661 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1417056..1417661 Mycobacterium leprae Br4923 7327210 YP_002503504.1 CDS MLBr_01200 NC_011896.1 1417780 1418706 D pseudouridine synthase 1417780..1418706 Mycobacterium leprae Br4923 7325426 YP_002503505.1 CDS dnaE NC_011896.1 1423041 1426574 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1423041..1426574 Mycobacterium leprae Br4923 7327073 YP_002503506.1 CDS ilvA NC_011896.1 1428278 1429561 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1428278..1429561 Mycobacterium leprae Br4923 7327074 YP_002503507.1 CDS MLBr_01210 NC_011896.1 1431121 1431306 D hypothetical protein 1431121..1431306 Mycobacterium leprae Br4923 7324708 YP_002503508.1 CDS MLBr_01213 NC_011896.1 1434706 1436907 R hypothetical protein complement(1434706..1436907) Mycobacterium leprae Br4923 7325345 YP_002503509.1 CDS MLBr_01214 NC_011896.1 1437037 1437675 R p60-family protein complement(1437037..1437675) Mycobacterium leprae Br4923 7327076 YP_002503510.1 CDS bioA NC_011896.1 1438624 1439934 D catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1438624..1439934 Mycobacterium leprae Br4923 7327078 YP_002503511.1 CDS bioF NC_011896.1 1439941 1441098 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1439941..1441098 Mycobacterium leprae Br4923 7327261 YP_002503512.1 CDS bioD NC_011896.1 1441095 1441775 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1441095..1441775 Mycobacterium leprae Br4923 7327264 YP_002503513.1 CDS bioB NC_011896.1 1442529 1443566 D catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1442529..1443566 Mycobacterium leprae Br4923 7327079 YP_002503514.1 CDS MLBr_01221 NC_011896.1 1443592 1443834 D hypothetical protein 1443592..1443834 Mycobacterium leprae Br4923 7327262 YP_002503515.1 CDS MLBr_01222 NC_011896.1 1443831 1444427 D hypothetical protein 1443831..1444427 Mycobacterium leprae Br4923 7327080 YP_002503516.1 CDS MLBr_01224 NC_011896.1 1445974 1446693 R hypothetical protein complement(1445974..1446693) Mycobacterium leprae Br4923 7327082 YP_002503517.1 CDS nadA NC_011896.1 1446740 1447798 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1446740..1447798 Mycobacterium leprae Br4923 7327083 YP_002503518.1 CDS nadB NC_011896.1 1447795 1449378 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1447795..1449378 Mycobacterium leprae Br4923 7324947 YP_002503519.1 CDS nadC NC_011896.1 1449375 1450235 D catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1449375..1450235 Mycobacterium leprae Br4923 7324948 YP_002503520.1 CDS pks3 NC_011896.1 1454324 1460680 D mycocerosic acid synthase (polyketide synthase) 1454324..1460680 Mycobacterium leprae Br4923 7327084 YP_002503521.1 CDS papA3 NC_011896.1 1460761 1462176 D PKS-associated protein 1460761..1462176 Mycobacterium leprae Br4923 7326439 YP_002503522.1 CDS mmpL10 NC_011896.1 1462258 1465209 D hypothetical protein 1462258..1465209 Mycobacterium leprae Br4923 7327351 YP_002503523.1 CDS MLBr_01232 NC_011896.1 1465637 1466713 R hypothetical protein complement(1465637..1466713) Mycobacterium leprae Br4923 7324905 YP_002503524.1 CDS MLBr_01233 NC_011896.1 1466878 1467570 R hypothetical protein complement(1466878..1467570) Mycobacterium leprae Br4923 7327085 YP_002503525.1 CDS MLBr_01234 NC_011896.1 1467600 1469339 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1467600..1469339) Mycobacterium leprae Br4923 7327086 YP_002503526.1 CDS MLBr_01241 NC_011896.1 1476575 1477459 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1476575..1477459 Mycobacterium leprae Br4923 7327091 YP_002503527.1 CDS MLBr_01243 NC_011896.1 1482157 1482618 D hypothetical protein 1482157..1482618 Mycobacterium leprae Br4923 7327229 YP_002503528.1 CDS MLBr_01244 NC_011896.1 1482841 1484316 D hypothetical protein 1482841..1484316 Mycobacterium leprae Br4923 7327094 YP_002503529.1 CDS MLBr_01245 NC_011896.1 1484313 1486052 D transferase 1484313..1486052 Mycobacterium leprae Br4923 7327095 YP_002503530.1 CDS plsB NC_011896.1 1486049 1488376 D PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1486049..1488376 Mycobacterium leprae Br4923 7327096 YP_002503531.1 CDS MLBr_01248 NC_011896.1 1489194 1490864 D ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1489194..1490864 Mycobacterium leprae Br4923 7327097 YP_002503532.1 CDS MLBr_01249 NC_011896.1 1490923 1495791 D hypothetical protein 1490923..1495791 Mycobacterium leprae Br4923 7327098 YP_002503533.1 CDS glbO NC_011896.1 1498175 1498561 R hemoglobin-like, oxygen carrier complement(1498175..1498561) Mycobacterium leprae Br4923 7327102 YP_002503534.1 CDS MLBr_01254 NC_011896.1 1498730 1499377 D hypothetical protein 1498730..1499377 Mycobacterium leprae Br4923 7325341 YP_002503535.1 CDS MLBr_01255 NC_011896.1 1499792 1500283 D hypothetical protein 1499792..1500283 Mycobacterium leprae Br4923 7327103 YP_002503536.1 CDS hisD NC_011896.1 1502321 1503670 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1502321..1503670 Mycobacterium leprae Br4923 7327105 YP_002503537.1 CDS hisC NC_011896.1 1503667 1504800 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1503667..1504800 Mycobacterium leprae Br4923 7324682 YP_002503538.1 CDS hisB NC_011896.1 1504797 1505429 D catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1504797..1505429 Mycobacterium leprae Br4923 7324680 YP_002503539.1 CDS hisH NC_011896.1 1505426 1506046 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1505426..1506046 Mycobacterium leprae Br4923 7324679 YP_002503540.1 CDS hisA NC_011896.1 1506056 1506793 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1506056..1506793 Mycobacterium leprae Br4923 7324686 YP_002503541.1 CDS hisF NC_011896.1 1507601 1508386 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1507601..1508386 Mycobacterium leprae Br4923 7324716 YP_002503542.1 CDS hisI NC_011896.1 1508383 1508730 D PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1508383..1508730 Mycobacterium leprae Br4923 7324684 YP_002503543.1 CDS MLBr_01267 NC_011896.1 1510464 1511558 D antiporter 1510464..1511558 Mycobacterium leprae Br4923 7327107 YP_002503544.1 CDS trpE NC_011896.1 1512163 1513752 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1512163..1513752 Mycobacterium leprae Br4923 7327109 YP_002503545.1 CDS MLBr_01270 NC_011896.1 1513749 1514546 D hypothetical protein 1513749..1514546 Mycobacterium leprae Br4923 7327284 YP_002503546.1 CDS trpC NC_011896.1 1514524 1515342 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1514524..1515342 Mycobacterium leprae Br4923 7327110 YP_002503547.1 CDS trpB NC_011896.1 1515406 1516659 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1515406..1516659 Mycobacterium leprae Br4923 7327282 YP_002503548.1 CDS trpA NC_011896.1 1516656 1517468 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1516656..1517468 Mycobacterium leprae Br4923 7327281 YP_002503549.1 CDS MLBr_01274 NC_011896.1 1517465 1518457 D prolipoprotein diacylglyceryl transferase 1517465..1518457 Mycobacterium leprae Br4923 7327280 YP_002503550.1 CDS MLBr_01275 NC_011896.1 1518454 1518690 D hypothetical protein 1518454..1518690 Mycobacterium leprae Br4923 7327111 YP_002503551.1 CDS MLBr_01276 NC_011896.1 1519242 1519682 D hypothetical protein 1519242..1519682 Mycobacterium leprae Br4923 7327112 YP_002503552.1 CDS pykA NC_011896.1 1519765 1521183 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1519765..1521183 Mycobacterium leprae Br4923 7327113 YP_002503553.1 CDS tesB NC_011896.1 1521290 1522183 D acyl CoA thioesterase II 1521290..1522183 Mycobacterium leprae Br4923 7325044 YP_002503554.1 CDS MLBr_01286 NC_011896.1 1531889 1532506 D two-component response regulatory protein 1531889..1532506 Mycobacterium leprae Br4923 7325380 YP_002503555.1 CDS MLBr_01288 NC_011896.1 1536172 1537575 D hypothetical protein 1536172..1537575 Mycobacterium leprae Br4923 7325379 YP_002503556.1 CDS MLBr_01289 NC_011896.1 1537607 1538137 D hypothetical protein 1537607..1538137 Mycobacterium leprae Br4923 7326444 YP_002503557.1 CDS MLBr_01292 NC_011896.1 1540635 1540877 R hypothetical protein complement(1540635..1540877) Mycobacterium leprae Br4923 7326447 YP_002503558.1 CDS pyrD NC_011896.1 1543287 1544360 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(1543287..1544360) Mycobacterium leprae Br4923 7326448 YP_002503559.1 CDS MLBr_01294 NC_011896.1 1544378 1544632 R hypothetical protein complement(1544378..1544632) Mycobacterium leprae Br4923 7325047 YP_002503560.1 CDS MLBr_01296 NC_011896.1 1545763 1546098 D hypothetical protein 1545763..1546098 Mycobacterium leprae Br4923 7326450 YP_002503561.1 CDS MLBr_01297 NC_011896.1 1546139 1546987 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 1546139..1546987 Mycobacterium leprae Br4923 7326451 YP_002503562.1 CDS MLBr_01298 NC_011896.1 1546984 1547736 D hypothetical protein 1546984..1547736 Mycobacterium leprae Br4923 7326452 YP_002503563.1 CDS MLBr_01299 NC_011896.1 1547814 1548404 D hypothetical protein 1547814..1548404 Mycobacterium leprae Br4923 7326453 YP_002503564.1 CDS MLBr_01300 NC_011896.1 1548415 1549203 D hypothetical protein 1548415..1549203 Mycobacterium leprae Br4923 7326454 YP_002503565.1 CDS MLBr_01301 NC_011896.1 1549242 1550057 D inositol monophosphatase 1549242..1550057 Mycobacterium leprae Br4923 7326455 YP_002503566.1 CDS cysS2 NC_011896.1 1550253 1551407 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1550253..1551407 Mycobacterium leprae Br4923 7326456 YP_002503567.1 CDS ansP1 NC_011896.1 1552542 1554038 R L-asparagine permease complement(1552542..1554038) Mycobacterium leprae Br4923 7326457 YP_002503568.1 CDS ansP2 NC_011896.1 1554188 1555705 R L-asparagine permease complement(1554188..1555705) Mycobacterium leprae Br4923 7327212 YP_002503569.1 CDS MLBr_01306 NC_011896.1 1555842 1556666 R hypothetical protein complement(1555842..1556666) Mycobacterium leprae Br4923 7327213 YP_002503570.1 CDS metH NC_011896.1 1556874 1560494 D 5-methyltetrahydrofolate--homocysteine methyltransferase 1556874..1560494 Mycobacterium leprae Br4923 7326458 YP_002503571.1 CDS hisE NC_011896.1 1561989 1562270 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 1561989..1562270 Mycobacterium leprae Br4923 7324991 YP_002503572.1 CDS hisG NC_011896.1 1562267 1563136 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1562267..1563136 Mycobacterium leprae Br4923 7324683 YP_002503573.1 CDS MLBr_01312 NC_011896.1 1565176 1566060 R hypothetical protein complement(1565176..1566060) Mycobacterium leprae Br4923 7326459 YP_002503574.1 CDS MLBr_01313 NC_011896.1 1566134 1566979 D hypothetical protein 1566134..1566979 Mycobacterium leprae Br4923 7326460 YP_002503575.1 CDS MLBr_01314 NC_011896.1 1567093 1567386 R hypothetical protein complement(1567093..1567386) Mycobacterium leprae Br4923 7326461 YP_002503576.1 CDS MLBr_01315 NC_011896.1 1567395 1567979 R lipoprotein complement(1567395..1567979) Mycobacterium leprae Br4923 7326462 YP_002503577.1 CDS MLBr_01316 NC_011896.1 1568267 1570096 D AAA ATPase 1568267..1570096 Mycobacterium leprae Br4923 7326463 YP_002503578.1 CDS MLBr_01320 NC_011896.1 1573940 1575484 D hypothetical protein 1573940..1575484 Mycobacterium leprae Br4923 7326467 YP_002503579.1 CDS MLBr_01321 NC_011896.1 1575516 1575707 D hypothetical protein 1575516..1575707 Mycobacterium leprae Br4923 7326468 YP_002503580.1 CDS prcB NC_011896.1 1575704 1576579 D proteasome beta-type subunit 2 1575704..1576579 Mycobacterium leprae Br4923 7326469 YP_002503581.1 CDS prcA NC_011896.1 1576576 1577373 D proteasome alpha-type subunit 1 1576576..1577373 Mycobacterium leprae Br4923 7325004 YP_002503582.1 CDS MLBr_01328 NC_011896.1 1579824 1581182 D DNA-binding protein 1579824..1581182 Mycobacterium leprae Br4923 7326473 YP_002503583.1 CDS MLBr_01329 NC_011896.1 1581189 1582184 D hypothetical protein 1581189..1582184 Mycobacterium leprae Br4923 7326474 YP_002503584.1 CDS MLBr_01330 NC_011896.1 1582181 1583155 D DNA-binding protein 1582181..1583155 Mycobacterium leprae Br4923 7326475 YP_002503585.1 CDS tatA NC_011896.1 1583207 1583494 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 1583207..1583494 Mycobacterium leprae Br4923 7326476 YP_002503586.1 CDS MLBr_01332 NC_011896.1 1583633 1584493 D membrane transport protein 1583633..1584493 Mycobacterium leprae Br4923 7326477 YP_002503587.1 CDS helY NC_011896.1 1584518 1587280 D helicase, Ski2 subfamily 1584518..1587280 Mycobacterium leprae Br4923 7326478 YP_002503588.1 CDS MLBr_01334 NC_011896.1 1587345 1588073 D hypothetical protein 1587345..1588073 Mycobacterium leprae Br4923 7324669 YP_002503589.1 CDS MLBr_01338 NC_011896.1 1595382 1596704 R hypothetical protein complement(1595382..1596704) Mycobacterium leprae Br4923 7326481 YP_002503590.1 CDS MLBr_01339 NC_011896.1 1596724 1598301 R protease complement(1596724..1598301) Mycobacterium leprae Br4923 7326482 YP_002503591.1 CDS MLBr_01340 NC_011896.1 1598315 1599121 R hypothetical protein complement(1598315..1599121) Mycobacterium leprae Br4923 7326483 YP_002503592.1 CDS MLBr_01344 NC_011896.1 1602915 1603175 R hypothetical protein complement(1602915..1603175) Mycobacterium leprae Br4923 7327311 YP_002503593.1 CDS MLBr_01346 NC_011896.1 1606046 1609054 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1606046..1609054 Mycobacterium leprae Br4923 7326489 YP_002503594.1 CDS MLBr_01347 NC_011896.1 1609047 1609280 D hypothetical protein 1609047..1609280 Mycobacterium leprae Br4923 7326490 YP_002503595.1 CDS MLBr_01351 NC_011896.1 1611453 1612097 D responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1611453..1612097 Mycobacterium leprae Br4923 7326494 YP_002503596.1 CDS tyrS NC_011896.1 1612108 1613388 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1612108..1613388 Mycobacterium leprae Br4923 7326495 YP_002503597.1 CDS MLBr_01357 NC_011896.1 1617849 1618034 D hypothetical protein 1617849..1618034 Mycobacterium leprae Br4923 7326499 YP_002503598.1 CDS tlyA NC_011896.1 1618042 1618851 D cytotoxin/hemolysin 1618042..1618851 Mycobacterium leprae Br4923 7326500 YP_002503599.1 CDS ppnK NC_011896.1 1618848 1619783 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1618848..1619783 Mycobacterium leprae Br4923 7326027 YP_002503600.1 CDS recN NC_011896.1 1619807 1621570 D recombination and DNA repair 1619807..1621570 Mycobacterium leprae Br4923 7326501 YP_002503601.1 CDS MLBr_01361 NC_011896.1 1621756 1622937 D hypothetical protein 1621756..1622937 Mycobacterium leprae Br4923 7326612 YP_002503602.1 CDS MLBr_01362 NC_011896.1 1622959 1623912 D hypothetical protein 1622959..1623912 Mycobacterium leprae Br4923 7326502 YP_002503603.1 CDS pyrG NC_011896.1 1624085 1625857 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1624085..1625857 Mycobacterium leprae Br4923 7326503 YP_002503604.1 CDS xerD NC_011896.1 1626471 1627421 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1626471..1627421 Mycobacterium leprae Br4923 7326504 YP_002503605.1 CDS MLBr_01367 NC_011896.1 1627962 1628825 D regulatory protein 1627962..1628825 Mycobacterium leprae Br4923 7326506 YP_002503606.1 CDS MLBr_01368 NC_011896.1 1628822 1629628 D hypothetical protein 1628822..1629628 Mycobacterium leprae Br4923 7326507 YP_002503607.1 CDS MLBr_01369 NC_011896.1 1629676 1630371 D hypothetical protein 1629676..1630371 Mycobacterium leprae Br4923 7326508 YP_002503608.1 CDS MLBr_01370 NC_011896.1 1630368 1631141 D pseudouridine synthase 1630368..1631141 Mycobacterium leprae Br4923 7326509 YP_002503609.1 CDS cmk NC_011896.1 1631138 1631809 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1631138..1631809 Mycobacterium leprae Br4923 7326510 YP_002503610.1 CDS engA NC_011896.1 1631803 1633191 D synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1631803..1633191 Mycobacterium leprae Br4923 7326113 YP_002503611.1 CDS MLBr_01380 NC_011896.1 1645003 1645566 D hypothetical protein 1645003..1645566 Mycobacterium leprae Br4923 7326518 YP_002503612.1 CDS polA NC_011896.1 1648153 1650888 R has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I complement(1648153..1650888) Mycobacterium leprae Br4923 7326519 YP_002503613.1 CDS rpsA NC_011896.1 1652661 1654106 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1652661..1654106 Mycobacterium leprae Br4923 7324980 YP_002503614.1 CDS coaE NC_011896.1 1654133 1655365 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1654133..1655365 Mycobacterium leprae Br4923 7326677 YP_002503615.1 CDS MLBr_01384 NC_011896.1 1656158 1656496 D hypothetical protein 1656158..1656496 Mycobacterium leprae Br4923 7326520 YP_002503616.1 CDS uvrB NC_011896.1 1661598 1663694 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1661598..1663694 Mycobacterium leprae Br4923 7327405 YP_002503617.1 CDS MLBr_01389 NC_011896.1 1665107 1666690 R hypothetical protein complement(1665107..1666690) Mycobacterium leprae Br4923 7326849 YP_002503618.1 CDS MLBr_01390 NC_011896.1 1666982 1667425 D hypothetical protein 1666982..1667425 Mycobacterium leprae Br4923 7326850 YP_002503619.1 CDS MLBr_01391 NC_011896.1 1667434 1668132 R hypothetical protein complement(1667434..1668132) Mycobacterium leprae Br4923 7326851 YP_002503620.1 CDS uvrA NC_011896.1 1668270 1671179 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1668270..1671179 Mycobacterium leprae Br4923 7326852 YP_002503621.1 CDS lysS NC_011896.1 1671856 1674975 R catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase complement(1671856..1674975) Mycobacterium leprae Br4923 7327305 YP_002503622.1 CDS infC NC_011896.1 1675740 1676297 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1675740..1676297 Mycobacterium leprae Br4923 7325433 YP_002503623.1 CDS rpmI NC_011896.1 1676348 1676542 D 50S ribosomal protein L35 1676348..1676542 Mycobacterium leprae Br4923 7324719 YP_002503624.1 CDS rplT NC_011896.1 1676596 1676985 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1676596..1676985 Mycobacterium leprae Br4923 7326671 YP_002503625.1 CDS tsnR NC_011896.1 1677040 1677819 D rRNA methyltransferase 1677040..1677819 Mycobacterium leprae Br4923 7326658 YP_002503626.1 CDS MLBr_01399 NC_011896.1 1679147 1680121 D hypothetical protein 1679147..1680121 Mycobacterium leprae Br4923 7326853 YP_002503627.1 CDS pheS NC_011896.1 1680970 1682022 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1680970..1682022 Mycobacterium leprae Br4923 7326855 YP_002503628.1 CDS pheT NC_011896.1 1682019 1684529 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1682019..1684529 Mycobacterium leprae Br4923 7327389 YP_002503629.1 CDS argC NC_011896.1 1687605 1688648 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1687605..1688648 Mycobacterium leprae Br4923 7326857 YP_002503630.1 CDS argJ NC_011896.1 1688645 1689868 D bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1688645..1689868 Mycobacterium leprae Br4923 7327218 YP_002503631.1 CDS argB NC_011896.1 1689865 1690770 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1689865..1690770 Mycobacterium leprae Br4923 7327223 YP_002503632.1 CDS argD NC_011896.1 1690822 1692036 D catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1690822..1692036 Mycobacterium leprae Br4923 7327217 YP_002503633.1 CDS argF NC_011896.1 1692068 1693030 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1692068..1693030 Mycobacterium leprae Br4923 7327219 YP_002503634.1 CDS argR NC_011896.1 1693033 1693536 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1693033..1693536 Mycobacterium leprae Br4923 7327220 YP_002503635.1 CDS argG NC_011896.1 1693546 1694745 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1693546..1694745 Mycobacterium leprae Br4923 7327224 YP_002503636.1 CDS argH NC_011896.1 1694817 1696229 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1694817..1696229 Mycobacterium leprae Br4923 7327221 YP_002503637.1 CDS MLBr_01417 NC_011896.1 1699581 1700387 D CDP-diacylglycerol pyrophosphatase 1699581..1700387 Mycobacterium leprae Br4923 7324969 YP_002503638.1 CDS MLBr_01418 NC_011896.1 1700629 1701177 R hypothetical protein complement(1700629..1701177) Mycobacterium leprae Br4923 7326859 YP_002503639.1 CDS MLBr_01419 NC_011896.1 1704287 1705978 R regulatory protein complement(1704287..1705978) Mycobacterium leprae Br4923 7326860 YP_002503640.1 CDS MLBr_01420 NC_011896.1 1706324 1706677 D hypothetical protein 1706324..1706677 Mycobacterium leprae Br4923 7326861 YP_002503641.1 CDS MLBr_01423 NC_011896.1 1710440 1711429 R hypothetical protein complement(1710440..1711429) Mycobacterium leprae Br4923 7326864 YP_002503642.1 CDS MLBr_01424 NC_011896.1 1711499 1712569 R binding-protein-dependent transport protein complement(1711499..1712569) Mycobacterium leprae Br4923 7326865 YP_002503643.1 CDS MLBr_01425 NC_011896.1 1712572 1713423 R ABC transporter inner membrane protein complement(1712572..1713423) Mycobacterium leprae Br4923 7326866 YP_002503644.1 CDS MLBr_01426 NC_011896.1 1713410 1714369 R ABC transporter inner membrane protein complement(1713410..1714369) Mycobacterium leprae Br4923 7326867 YP_002503645.1 CDS MLBr_01427 NC_011896.1 1714366 1715703 R ABC-transport lipoprotein complement(1714366..1715703) Mycobacterium leprae Br4923 7326868 YP_002503646.1 CDS MLBr_01430 NC_011896.1 1716857 1717183 D hypothetical protein 1716857..1717183 Mycobacterium leprae Br4923 7326870 YP_002503647.1 CDS MLBr_01439 NC_011896.1 1733280 1733615 D hypothetical protein 1733280..1733615 Mycobacterium leprae Br4923 7326875 YP_002503648.1 CDS MLBr_01440 NC_011896.1 1733572 1734405 R glycosyl transferase family protein complement(1733572..1734405) Mycobacterium leprae Br4923 7326876 YP_002503649.1 CDS MLBr_01441 NC_011896.1 1734402 1736336 R apolipoprotein N-acyltransferase complement(1734402..1736336) Mycobacterium leprae Br4923 7326877 YP_002503650.1 CDS MLBr_01444 NC_011896.1 1738528 1739226 D dienelactone hydrolase 1738528..1739226 Mycobacterium leprae Br4923 7326880 YP_002503651.1 CDS MLBr_01445 NC_011896.1 1739584 1739808 R hypothetical protein complement(1739584..1739808) Mycobacterium leprae Br4923 7326881 YP_002503652.1 CDS MLBr_01446 NC_011896.1 1740031 1740417 R hypothetical protein complement(1740031..1740417) Mycobacterium leprae Br4923 7326882 YP_002503653.1 CDS MLBr_01448 NC_011896.1 1740837 1741391 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 1740837..1741391 Mycobacterium leprae Br4923 7326122 YP_002503654.1 CDS MLBr_01452 NC_011896.1 1746816 1747490 R phosphoglycerate mutase complement(1746816..1747490) Mycobacterium leprae Br4923 7326885 YP_002503655.1 CDS MLBr_01453 NC_011896.1 1747490 1747879 R hypothetical protein complement(1747490..1747879) Mycobacterium leprae Br4923 7326886 YP_002503656.1 CDS nadD NC_011896.1 1747876 1748520 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1747876..1748520) Mycobacterium leprae Br4923 7326887 YP_002503657.1 CDS proA NC_011896.1 1751680 1752909 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(1751680..1752909) Mycobacterium leprae Br4923 7326891 YP_002503658.1 CDS nadE NC_011896.1 1759234 1761276 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1759234..1761276) Mycobacterium leprae Br4923 7326894 YP_002503659.1 CDS proB NC_011896.1 1761493 1762596 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(1761493..1762596) Mycobacterium leprae Br4923 7326895 YP_002503660.1 CDS obgE NC_011896.1 1762600 1764039 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1762600..1764039) Mycobacterium leprae Br4923 7325009 YP_002503661.1 CDS rpmA NC_011896.1 1764154 1764420 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1764154..1764420) Mycobacterium leprae Br4923 7326896 YP_002503662.1 CDS rplU NC_011896.1 1764432 1764743 R 50S ribosomal protein L21 complement(1764432..1764743) Mycobacterium leprae Br4923 7326664 YP_002503663.1 CDS MLBr_01468 NC_011896.1 1764970 1767744 R ribonuclease complement(1764970..1767744) Mycobacterium leprae Br4923 7326659 YP_002503664.1 CDS ndk NC_011896.1 1768087 1768497 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1768087..1768497) Mycobacterium leprae Br4923 7326897 YP_002503665.1 CDS MLBr_01470 NC_011896.1 1768547 1768918 R hypothetical protein complement(1768547..1768918) Mycobacterium leprae Br4923 7324958 YP_002503666.1 CDS folC NC_011896.1 1768915 1770372 R folylpolyglutamate synthase complement(1768915..1770372) Mycobacterium leprae Br4923 7326898 YP_002503667.1 CDS valS NC_011896.1 1770369 1773029 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(1770369..1773029) Mycobacterium leprae Br4923 7325302 YP_002503668.1 CDS clpX NC_011896.1 1779702 1780982 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1779702..1780982) Mycobacterium leprae Br4923 7326902 YP_002503669.1 CDS mmuM NC_011896.1 1781255 1782136 D converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 1781255..1782136 Mycobacterium leprae Br4923 7326765 YP_002503670.1 CDS clpP2 NC_011896.1 1782133 1782777 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1782133..1782777) Mycobacterium leprae Br4923 7326903 YP_002503671.1 CDS clpP NC_011896.1 1782774 1783448 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1782774..1783448) Mycobacterium leprae Br4923 7327276 YP_002503672.1 CDS tig NC_011896.1 1783500 1784909 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(1783500..1784909) Mycobacterium leprae Br4923 7327275 YP_002503673.1 CDS MLBr_01484 NC_011896.1 1787315 1787803 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B complement(1787315..1787803) Mycobacterium leprae Br4923 7326905 YP_002503674.1 CDS MLBr_01485 NC_011896.1 1787844 1788467 R hypothetical protein complement(1787844..1788467) Mycobacterium leprae Br4923 7326906 YP_002503675.1 CDS MLBr_01486 NC_011896.1 1788599 1791187 D aminopeptidase 1788599..1791187 Mycobacterium leprae Br4923 7326907 YP_002503676.1 CDS MLBr_01488 NC_011896.1 1792887 1793990 R catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase complement(1792887..1793990) Mycobacterium leprae Br4923 7326909 YP_002503677.1 CDS fdxA NC_011896.1 1794028 1794354 R ferredoxin complement(1794028..1794354) Mycobacterium leprae Br4923 7326910 YP_002503678.1 CDS fbiC NC_011896.1 1797541 1800132 R 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase complement(1797541..1800132) Mycobacterium leprae Br4923 7326911 YP_002503679.1 CDS MLBr_01494 NC_011896.1 1801299 1801652 R hypothetical protein complement(1801299..1801652) Mycobacterium leprae Br4923 7327368 YP_002503680.1 CDS MLBr_01495 NC_011896.1 1801817 1802743 R hypothetical protein complement(1801817..1802743) Mycobacterium leprae Br4923 7326913 YP_002503681.1 CDS MLBr_01497 NC_011896.1 1803550 1805403 R hypothetical protein complement(1803550..1805403) Mycobacterium leprae Br4923 7326915 YP_002503682.1 CDS MLBr_01498 NC_011896.1 1805470 1807356 R GTP-binding, protein elongation factor complement(1805470..1807356) Mycobacterium leprae Br4923 7326916 YP_002503683.1 CDS phhB NC_011896.1 1815020 1815304 D 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1815020..1815304 Mycobacterium leprae Br4923 7324944 YP_002503684.1 CDS pimE NC_011896.1 1815291 1816583 R involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase complement(1815291..1816583) Mycobacterium leprae Br4923 7326918 YP_002503685.1 CDS MLBr_01505 NC_011896.1 1816687 1817229 D hypothetical protein 1816687..1817229 Mycobacterium leprae Br4923 7326919 YP_002503686.1 CDS MLBr_01506 NC_011896.1 1817257 1818303 D hypothetical protein 1817257..1818303 Mycobacterium leprae Br4923 7326920 YP_002503687.1 CDS MLBr_01508 NC_011896.1 1819480 1819971 R hypothetical protein complement(1819480..1819971) Mycobacterium leprae Br4923 7326922 YP_002503688.1 CDS MLBr_01511 NC_011896.1 1821166 1821879 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1821166..1821879 Mycobacterium leprae Br4923 7326925 YP_002503689.1 CDS MLBr_01512 NC_011896.1 1822854 1824530 R hypothetical protein complement(1822854..1824530) Mycobacterium leprae Br4923 7326926 YP_002503690.1 CDS dapA NC_011896.1 1824550 1825452 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(1824550..1825452) Mycobacterium leprae Br4923 7326927 YP_002503691.1 CDS thyX NC_011896.1 1825568 1826332 R flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase complement(1825568..1826332) Mycobacterium leprae Br4923 7326158 YP_002503692.1 CDS MLBr_01517 NC_011896.1 1831316 1831597 R hypothetical protein complement(1831316..1831597) Mycobacterium leprae Br4923 7324695 YP_002503693.1 CDS folA NC_011896.1 1832399 1832896 R dihydrofolate reductase complement(1832399..1832896) Mycobacterium leprae Br4923 7325707 YP_002503694.1 CDS thyA NC_011896.1 1832949 1833749 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(1832949..1833749) Mycobacterium leprae Br4923 7325300 YP_002503695.1 CDS MLBr_01523 NC_011896.1 1837743 1838033 R hypothetical protein complement(1837743..1838033) Mycobacterium leprae Br4923 7325235 YP_002503696.1 CDS MLBr_01525 NC_011896.1 1839934 1840389 R hypothetical protein complement(1839934..1840389) Mycobacterium leprae Br4923 7325711 YP_002503697.1 CDS MLBr_01526 NC_011896.1 1840397 1840879 R hypothetical protein complement(1840397..1840879) Mycobacterium leprae Br4923 7325712 YP_002503698.1 CDS ald NC_011896.1 1846890 1848005 D L-alanine dehydrogenase 1846890..1848005 Mycobacterium leprae Br4923 7325717 YP_002503699.1 CDS MLBr_01536 NC_011896.1 1851655 1853487 R hypothetical protein complement(1851655..1853487) Mycobacterium leprae Br4923 7325718 YP_002503700.1 CDS MLBr_01537 NC_011896.1 1853484 1854689 R hypothetical protein complement(1853484..1854689) Mycobacterium leprae Br4923 7325719 YP_002503701.1 CDS MLBr_01538 NC_011896.1 1854710 1856413 R protease complement(1854710..1856413) Mycobacterium leprae Br4923 7325720 YP_002503702.1 CDS MLBr_01539 NC_011896.1 1856445 1857956 R hypothetical protein complement(1856445..1857956) Mycobacterium leprae Br4923 7325721 YP_002503703.1 CDS MLBr_01540 NC_011896.1 1858220 1859122 R hypothetical protein complement(1858220..1859122) Mycobacterium leprae Br4923 7325722 YP_002503704.1 CDS MLBr_01543 NC_011896.1 1862140 1866177 R SpoIIIE-family membrane protein complement(1862140..1866177) Mycobacterium leprae Br4923 7325725 YP_002503705.1 CDS MLBr_01544 NC_011896.1 1866294 1867814 R hypothetical protein complement(1866294..1867814) Mycobacterium leprae Br4923 7325726 YP_002503706.1 CDS truB NC_011896.1 1870924 1871886 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1870924..1871886) Mycobacterium leprae Br4923 7325728 YP_002503707.1 CDS MLBr_01547 NC_011896.1 1871883 1872566 R hypothetical protein complement(1871883..1872566) Mycobacterium leprae Br4923 7327288 YP_002503708.1 CDS MLBr_01548 NC_011896.1 1872563 1873528 R hypothetical protein complement(1872563..1873528) Mycobacterium leprae Br4923 7325729 YP_002503709.1 CDS proS NC_011896.1 1877167 1878609 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1877167..1878609 Mycobacterium leprae Br4923 7325213 YP_002503710.1 CDS rbfA NC_011896.1 1879594 1880088 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(1879594..1880088) Mycobacterium leprae Br4923 7325734 YP_002503711.1 CDS infB NC_011896.1 1880102 1882876 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1880102..1882876) Mycobacterium leprae Br4923 7325735 YP_002503712.1 CDS MLBr_01557 NC_011896.1 1882941 1883261 R hypothetical protein complement(1882941..1883261) Mycobacterium leprae Br4923 7324718 YP_002503713.1 CDS nusA NC_011896.1 1883461 1884504 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1883461..1884504) Mycobacterium leprae Br4923 7325736 YP_002503714.1 CDS MLBr_01560 NC_011896.1 1885164 1885700 D hypothetical protein 1885164..1885700 Mycobacterium leprae Br4923 7325737 YP_002503715.1 CDS MLBr_01561 NC_011896.1 1885697 1886194 D hypothetical protein 1885697..1886194 Mycobacterium leprae Br4923 7325738 YP_002503716.1 CDS MLBr_01562 NC_011896.1 1886219 1887823 R transmembrane efflux protein complement(1886219..1887823) Mycobacterium leprae Br4923 7325739 YP_002503717.1 CDS MLBr_01572 NC_011896.1 1898049 1898447 D hypothetical protein 1898049..1898447 Mycobacterium leprae Br4923 7324959 YP_002503718.1 CDS MLBr_01573 NC_011896.1 1898908 1899657 R amidotransferase complement(1898908..1899657) Mycobacterium leprae Br4923 7325745 YP_002503719.1 CDS MLBr_01575 NC_011896.1 1900094 1900387 R hypothetical protein complement(1900094..1900387) Mycobacterium leprae Br4923 7325352 YP_002503720.1 CDS mapB NC_011896.1 1900811 1901668 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase complement(1900811..1901668) Mycobacterium leprae Br4923 7325747 YP_002503721.1 CDS MLBr_01577 NC_011896.1 1901860 1903686 R penicillin binding protein complement(1901860..1903686) Mycobacterium leprae Br4923 7325437 YP_002503722.1 CDS ispG NC_011896.1 1905686 1906864 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(1905686..1906864) Mycobacterium leprae Br4923 7325751 YP_002503723.1 CDS MLBr_01582 NC_011896.1 1906917 1908131 R integral membrane protein complement(1906917..1908131) Mycobacterium leprae Br4923 7325335 YP_002503724.1 CDS MLBr_01583 NC_011896.1 1908140 1909360 R catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase complement(1908140..1909360) Mycobacterium leprae Br4923 7325752 YP_002503725.1 CDS MLBr_01584 NC_011896.1 1909515 1909769 D hypothetical protein 1909515..1909769 Mycobacterium leprae Br4923 7325753 YP_002503726.1 CDS MLBr_01589 NC_011896.1 1913823 1914761 R phosphatidate cytidylyltransferase complement(1913823..1914761) Mycobacterium leprae Br4923 7325757 YP_002503727.1 CDS frr NC_011896.1 1914793 1915350 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(1914793..1915350) Mycobacterium leprae Br4923 7325758 YP_002503728.1 CDS pyrH NC_011896.1 1915409 1916248 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(1915409..1916248) Mycobacterium leprae Br4923 7325311 YP_002503729.1 CDS MLBr_01596 NC_011896.1 1920839 1922245 R catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase complement(1920839..1922245) Mycobacterium leprae Br4923 7325763 YP_002503730.1 CDS tsf NC_011896.1 1922281 1923111 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(1922281..1923111) Mycobacterium leprae Br4923 7325764 YP_002503731.1 CDS rpsB NC_011896.1 1923113 1923946 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(1923113..1923946) Mycobacterium leprae Br4923 7327291 YP_002503732.1 CDS xerC NC_011896.1 1924770 1925663 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(1924770..1925663) Mycobacterium leprae Br4923 7325765 YP_002503733.1 CDS MLBr_01601 NC_011896.1 1926680 1927045 R hypothetical protein complement(1926680..1927045) Mycobacterium leprae Br4923 7327320 YP_002503734.1 CDS MLBr_01602 NC_011896.1 1927729 1928049 R hypothetical protein complement(1927729..1928049) Mycobacterium leprae Br4923 7325766 YP_002503735.1 CDS MLBr_01603 NC_011896.1 1928302 1928562 R hypothetical protein complement(1928302..1928562) Mycobacterium leprae Br4923 7325767 YP_002503736.1 CDS MLBr_01604 NC_011896.1 1928772 1929161 R hypothetical protein complement(1928772..1929161) Mycobacterium leprae Br4923 7325768 YP_002503737.1 CDS MLBr_01605 NC_011896.1 1931132 1931332 D hypothetical protein 1931132..1931332 Mycobacterium leprae Br4923 7325769 YP_002503738.1 CDS MLBr_01607 NC_011896.1 1932626 1932916 R hypothetical protein complement(1932626..1932916) Mycobacterium leprae Br4923 7325771 YP_002503739.1 CDS MLBr_01610 NC_011896.1 1934946 1935251 R hypothetical protein complement(1934946..1935251) Mycobacterium leprae Br4923 7325293 YP_002503740.1 CDS rnhB NC_011896.1 1935364 1936086 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(1935364..1936086) Mycobacterium leprae Br4923 7325773 YP_002503741.1 CDS MLBr_01612 NC_011896.1 1936089 1936958 R ignal peptidase I complement(1936089..1936958) Mycobacterium leprae Br4923 7326633 YP_002503742.1 CDS rplS NC_011896.1 1937038 1937379 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1937038..1937379) Mycobacterium leprae Br4923 7325774 YP_002503743.1 CDS trmD NC_011896.1 1938665 1939381 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(1938665..1939381) Mycobacterium leprae Br4923 7325412 YP_002503744.1 CDS rimM NC_011896.1 1939378 1939917 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(1939378..1939917) Mycobacterium leprae Br4923 7327279 YP_002503745.1 CDS MLBr_01617 NC_011896.1 1939922 1940164 R hypothetical protein complement(1939922..1940164) Mycobacterium leprae Br4923 7326626 YP_002503746.1 CDS rpsP NC_011896.1 1940189 1940671 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(1940189..1940671) Mycobacterium leprae Br4923 7325775 YP_002503747.1 CDS ffh NC_011896.1 1943727 1945292 R signal recognition particle protein complement(1943727..1945292) Mycobacterium leprae Br4923 7325777 YP_002503748.1 CDS htpG NC_011896.1 1945431 1947401 D molecular chaperone; heat shock protein 90 1945431..1947401 Mycobacterium leprae Br4923 7325297 YP_002503749.1 CDS MLBr_01624 NC_011896.1 1947563 1949353 D hypothetical protein 1947563..1949353 Mycobacterium leprae Br4923 7324699 YP_002503750.1 CDS MLBr_01628 NC_011896.1 1953374 1954666 R SRP family of GTP-binding protein complement(1953374..1954666) Mycobacterium leprae Br4923 7327209 YP_002503751.1 CDS smc NC_011896.1 1954780 1958391 R cell division protein complement(1954780..1958391) Mycobacterium leprae Br4923 7325779 YP_002503752.1 CDS glnE NC_011896.1 1959811 1962825 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(1959811..1962825) Mycobacterium leprae Br4923 7325995 YP_002503753.1 CDS glnA2 NC_011896.1 1962856 1964202 R glutamine synthase class II complement(1962856..1964202) Mycobacterium leprae Br4923 7325355 YP_002503754.1 CDS MLBr_01632 NC_011896.1 1964299 1965834 R hydrolase complement(1964299..1965834) Mycobacterium leprae Br4923 7325350 YP_002503755.1 CDS MLBr_01633 NC_011896.1 1965909 1967516 R hydrolase complement(1965909..1967516) Mycobacterium leprae Br4923 7325780 YP_002503756.1 CDS panB NC_011896.1 1969054 1969914 D catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1969054..1969914 Mycobacterium leprae Br4923 7325782 YP_002503757.1 CDS MLBr_01637 NC_011896.1 1973936 1975051 R bifunctional RNase H/acid phosphatase complement(1973936..1975051) Mycobacterium leprae Br4923 7327330 YP_002503758.1 CDS MLBr_01638 NC_011896.1 1975048 1975746 R hypothetical protein complement(1975048..1975746) Mycobacterium leprae Br4923 7325784 YP_002503759.1 CDS MLBr_01639 NC_011896.1 1975792 1976949 R hypothetical protein complement(1975792..1976949) Mycobacterium leprae Br4923 7325785 YP_002503760.1 CDS MLBr_01644 NC_011896.1 1978887 1979699 D hypothetical protein 1978887..1979699 Mycobacterium leprae Br4923 7325030 YP_002503761.1 CDS MLBr_01649 NC_011896.1 1987756 1988178 R hypothetical protein complement(1987756..1988178) Mycobacterium leprae Br4923 7327197 YP_002503762.1 CDS aceE NC_011896.1 1989091 1991901 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1989091..1991901 Mycobacterium leprae Br4923 7326772 YP_002503763.1 CDS MLBr_01652 NC_011896.1 1991987 1993231 D hypothetical protein 1991987..1993231 Mycobacterium leprae Br4923 7327182 YP_002503764.1 CDS fabD NC_011896.1 1993442 1994356 D malonyl CoA-[ACP] transacylase 1993442..1994356 Mycobacterium leprae Br4923 7326773 YP_002503765.1 CDS acpP NC_011896.1 1994456 1994803 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1994456..1994803 Mycobacterium leprae Br4923 7325232 YP_002503766.1 CDS kasA NC_011896.1 1994800 1996050 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1994800..1996050 Mycobacterium leprae Br4923 7327185 YP_002503767.1 CDS kasB NC_011896.1 1996063 1997340 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1996063..1997340 Mycobacterium leprae Br4923 7324722 YP_002503768.1 CDS MLBr_01657 NC_011896.1 1997371 1998792 D acetyl/propionyl CoA carboxylase subunit beta 1997371..1998792 Mycobacterium leprae Br4923 7324723 YP_002503769.1 CDS fpg NC_011896.1 1999918 2000766 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(1999918..2000766) Mycobacterium leprae Br4923 7326774 YP_002503770.1 CDS rnc NC_011896.1 2000821 2001537 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2000821..2001537) Mycobacterium leprae Br4923 7325308 YP_002503771.1 CDS MLBr_01660 NC_011896.1 2001534 2002187 R hypothetical protein complement(2001534..2002187) Mycobacterium leprae Br4923 7326632 YP_002503772.1 CDS MLBr_01661 NC_011896.1 2002221 2002964 R hypothetical protein complement(2002221..2002964) Mycobacterium leprae Br4923 7326775 YP_002503773.1 CDS coaD NC_011896.1 2005059 2005532 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(2005059..2005532) Mycobacterium leprae Br4923 7326777 YP_002503774.1 CDS MLBr_01664 NC_011896.1 2005564 2006037 R hypothetical protein complement(2005564..2006037) Mycobacterium leprae Br4923 7326115 YP_002503775.1 CDS MLBr_01666 NC_011896.1 2009528 2010172 R hypothetical protein complement(2009528..2010172) Mycobacterium leprae Br4923 7327356 YP_002503776.1 CDS MLBr_01667 NC_011896.1 2010181 2010975 R hypothetical protein complement(2010181..2010975) Mycobacterium leprae Br4923 7326779 YP_002503777.1 CDS MLBr_01669 NC_011896.1 2012983 2013831 D oxidoreductase 2012983..2013831 Mycobacterium leprae Br4923 7325397 YP_002503778.1 CDS recG NC_011896.1 2014650 2016881 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(2014650..2016881) Mycobacterium leprae Br4923 7326782 YP_002503779.1 CDS ung NC_011896.1 2019204 2019887 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(2019204..2019887) Mycobacterium leprae Br4923 7326665 YP_002503780.1 CDS thiL NC_011896.1 2020001 2020978 R catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase complement(2020001..2020978) Mycobacterium leprae Br4923 7327300 YP_002503781.1 CDS MLBr_01677 NC_011896.1 2021162 2021737 D hypothetical protein 2021162..2021737 Mycobacterium leprae Br4923 7326017 YP_002503782.1 CDS ddl NC_011896.1 2021746 2022900 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(2021746..2022900) Mycobacterium leprae Br4923 7326785 YP_002503783.1 CDS gpsA NC_011896.1 2023012 2024067 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(2023012..2024067) Mycobacterium leprae Br4923 7326162 YP_002503784.1 CDS MLBr_01680 NC_011896.1 2024608 2025258 D hypothetical protein 2024608..2025258 Mycobacterium leprae Br4923 7324654 YP_002503785.1 CDS MLBr_01681 NC_011896.1 2025342 2027561 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2025342..2027561 Mycobacterium leprae Br4923 7326786 YP_002503786.1 CDS MLBr_01682 NC_011896.1 2027640 2028575 D hypothetical protein 2027640..2028575 Mycobacterium leprae Br4923 7326787 YP_002503787.1 CDS MLBr_01683 NC_011896.1 2028644 2029246 R histone-like protein complement(2028644..2029246) Mycobacterium leprae Br4923 7326788 YP_002503788.1 CDS leuD NC_011896.1 2029460 2030056 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(2029460..2030056) Mycobacterium leprae Br4923 7326789 YP_002503789.1 CDS leuC NC_011896.1 2030099 2031556 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(2030099..2031556) Mycobacterium leprae Br4923 7324731 YP_002503790.1 CDS gltX NC_011896.1 2033511 2035019 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2033511..2035019) Mycobacterium leprae Br4923 7325359 YP_002503791.1 CDS MLBr_01689 NC_011896.1 2035016 2035744 R hydrolase complement(2035016..2035744) Mycobacterium leprae Br4923 7325368 YP_002503792.1 CDS leuB NC_011896.1 2037082 2038092 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(2037082..2038092) Mycobacterium leprae Br4923 7326793 YP_002503793.1 CDS serA NC_011896.1 2038142 2039728 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(2038142..2039728) Mycobacterium leprae Br4923 7324729 YP_002503794.1 CDS ilvC NC_011896.1 2042647 2043648 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(2042647..2043648) Mycobacterium leprae Br4923 7326794 YP_002503795.1 CDS ilvH NC_011896.1 2043701 2044210 R with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit complement(2043701..2044210) Mycobacterium leprae Br4923 7324710 YP_002503796.1 CDS ilvB NC_011896.1 2044262 2046139 R acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit complement(2044262..2046139) Mycobacterium leprae Br4923 7324714 YP_002503797.1 CDS MLBr_01698 NC_011896.1 2046911 2047744 R hypothetical protein complement(2046911..2047744) Mycobacterium leprae Br4923 7326795 YP_002503798.1 CDS MLBr_01699 NC_011896.1 2047987 2049105 D lipoprotein 2047987..2049105 Mycobacterium leprae Br4923 7326796 YP_002503799.1 CDS gatB NC_011896.1 2050047 2051576 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(2050047..2051576) Mycobacterium leprae Br4923 7326797 YP_002503800.1 CDS pfkA NC_011896.1 2051925 2052956 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(2051925..2052956) Mycobacterium leprae Br4923 7325332 YP_002503801.1 CDS gatA NC_011896.1 2053044 2054537 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(2053044..2054537) Mycobacterium leprae Br4923 7327381 YP_002503802.1 CDS gatC NC_011896.1 2054534 2054833 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(2054534..2054833) Mycobacterium leprae Br4923 7325331 YP_002503803.1 CDS MLBr_01704 NC_011896.1 2054970 2055668 D hypothetical protein 2054970..2055668 Mycobacterium leprae Br4923 7325333 YP_002503804.1 CDS ligA NC_011896.1 2055671 2057755 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2055671..2057755) Mycobacterium leprae Br4923 7326798 YP_002503805.1 CDS MLBr_01706 NC_011896.1 2057814 2058827 R hypothetical protein complement(2057814..2058827) Mycobacterium leprae Br4923 7325385 YP_002503806.1 CDS mnmA NC_011896.1 2059743 2060819 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(2059743..2060819) Mycobacterium leprae Br4923 7326799 YP_002503807.1 CDS MLBr_01708 NC_011896.1 2060816 2062048 R aminotransferase complement(2060816..2062048) Mycobacterium leprae Br4923 7326800 YP_002503808.1 CDS eftA NC_011896.1 2064002 2064958 R electron transfer flavoprotein alpha subunit complement(2064002..2064958) Mycobacterium leprae Br4923 7326803 YP_002503809.1 CDS eftB NC_011896.1 2065007 2065807 R electron transfer flavoprotein subunit beta complement(2065007..2065807) Mycobacterium leprae Br4923 7325222 YP_002503810.1 CDS MLBr_01713 NC_011896.1 2066035 2066877 D hypothetical protein 2066035..2066877 Mycobacterium leprae Br4923 7325223 YP_002503811.1 CDS MLBr_01714 NC_011896.1 2066874 2068442 D hypothetical protein 2066874..2068442 Mycobacterium leprae Br4923 7326804 YP_002503812.1 CDS MLBr_01715 NC_011896.1 2068468 2069784 D transferase 2068468..2069784 Mycobacterium leprae Br4923 7326805 YP_002503813.1 CDS MLBr_01717 NC_011896.1 2071280 2071573 R hypothetical protein complement(2071280..2071573) Mycobacterium leprae Br4923 7326807 YP_002503814.1 CDS MLBr_01719 NC_011896.1 2074851 2075588 R hypothetical protein complement(2074851..2075588) Mycobacterium leprae Br4923 7326809 YP_002503815.1 CDS MLBr_01720 NC_011896.1 2076028 2077122 D hypothetical protein 2076028..2077122 Mycobacterium leprae Br4923 7326810 YP_002503816.1 CDS MLBr_01723 NC_011896.1 2079702 2080685 R hypothetical protein complement(2079702..2080685) Mycobacterium leprae Br4923 7326813 YP_002503817.1 CDS MLBr_01724 NC_011896.1 2080718 2081476 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2080718..2081476) Mycobacterium leprae Br4923 7326814 YP_002503818.1 CDS MLBr_01726 NC_011896.1 2082348 2083265 R ABC transporter protein, ATP-binding component complement(2082348..2083265) Mycobacterium leprae Br4923 7326816 YP_002503819.1 CDS MLBr_01727 NC_011896.1 2083275 2084510 R phosphoserine phosphatase complement(2083275..2084510) Mycobacterium leprae Br4923 7326817 YP_002503820.1 CDS MLBr_01728 NC_011896.1 2084550 2086274 R cytochrome C oxidase, polypeptide I complement(2084550..2086274) Mycobacterium leprae Br4923 7326818 YP_002503821.1 CDS fecB NC_011896.1 2086489 2087583 D FeIII-dicitrate transporter lipoprotein 2086489..2087583 Mycobacterium leprae Br4923 7326819 YP_002503822.1 CDS adhA NC_011896.1 2087843 2088931 D alcohol dehydrogenase 2087843..2088931 Mycobacterium leprae Br4923 7325295 YP_002503823.1 CDS nrdF NC_011896.1 2090540 2091517 R B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta complement(2090540..2091517) Mycobacterium leprae Br4923 7327189 YP_002503824.1 CDS MLBr_01733 NC_011896.1 2093377 2094204 R TetR family transcriptional regulator complement(2093377..2094204) Mycobacterium leprae Br4923 7326820 YP_002503825.1 CDS nrdE NC_011896.1 2094251 2096332 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(2094251..2096332) Mycobacterium leprae Br4923 7326821 YP_002503826.1 CDS nrdI NC_011896.1 2096417 2096833 R in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein complement(2096417..2096833) Mycobacterium leprae Br4923 7324963 YP_002503827.1 CDS nrdH NC_011896.1 2096862 2097104 R glutaredoxin electron transport component of NrdEF complement(2096862..2097104) Mycobacterium leprae Br4923 7324966 YP_002503828.1 CDS MLBr_01740 NC_011896.1 2099908 2100846 R short chain dehydrogenase complement(2099908..2100846) Mycobacterium leprae Br4923 7326172 YP_002503829.1 CDS MLBr_01750 NC_011896.1 2115048 2116919 R hypothetical protein complement(2115048..2116919) Mycobacterium leprae Br4923 7326829 YP_002503830.1 CDS MLBr_01751 NC_011896.1 2116937 2119102 R hypothetical protein complement(2116937..2119102) Mycobacterium leprae Br4923 7326830 YP_002503831.1 CDS MLBr_01752 NC_011896.1 2121246 2122154 R hypothetical protein complement(2121246..2122154) Mycobacterium leprae Br4923 7326831 YP_002503832.1 CDS MLBr_01753 NC_011896.1 2123695 2127015 R transcriptional regulator complement(2123695..2127015) Mycobacterium leprae Br4923 7326832 YP_002503833.1 CDS sdaA NC_011896.1 2129584 2130960 R L-serine dehydratase complement(2129584..2130960) Mycobacterium leprae Br4923 7326834 YP_002503834.1 CDS MLBr_01756 NC_011896.1 2131218 2131541 D multidrug resistance protein 2131218..2131541 Mycobacterium leprae Br4923 7325968 YP_002503835.1 CDS MLBr_01761 NC_011896.1 2135954 2136298 R hypothetical protein complement(2135954..2136298) Mycobacterium leprae Br4923 7326838 YP_002503836.1 CDS MLBr_01763 NC_011896.1 2138690 2138905 D hypothetical protein 2138690..2138905 Mycobacterium leprae Br4923 7326840 YP_002503837.1 CDS uspA NC_011896.1 2143203 2144189 D sugar transport integral membrane protein 2143203..2144189 Mycobacterium leprae Br4923 7326845 YP_002503838.1 CDS uspE NC_011896.1 2144176 2145000 D sugar transport integral membrane protein 2144176..2145000 Mycobacterium leprae Br4923 7327302 YP_002503839.1 CDS uspC NC_011896.1 2145092 2146432 D sugar transport periplasmic binding protein 2145092..2146432 Mycobacterium leprae Br4923 7327304 YP_002503840.1 CDS MLBr_01781 NC_011896.1 2157600 2158112 R hypothetical protein complement(2157600..2158112) Mycobacterium leprae Br4923 7325871 YP_002503841.1 CDS MLBr_01782 NC_011896.1 2158251 2159072 R hypothetical protein complement(2158251..2159072) Mycobacterium leprae Br4923 7325872 YP_002503842.1 CDS MLBr_01783 NC_011896.1 2159072 2160040 R transcriptional regulator complement(2159072..2160040) Mycobacterium leprae Br4923 7325873 YP_002503843.1 CDS adhE2 NC_011896.1 2160202 2161287 D alcohol dehydrogenase 2160202..2161287 Mycobacterium leprae Br4923 7325874 YP_002503844.1 CDS MLBr_01788 NC_011896.1 2163282 2163746 R hypothetical protein complement(2163282..2163746) Mycobacterium leprae Br4923 7325877 YP_002503845.1 CDS MLBr_01791 NC_011896.1 2165547 2165990 R hypothetical protein complement(2165547..2165990) Mycobacterium leprae Br4923 7325880 YP_002503846.1 CDS MLBr_01793 NC_011896.1 2168940 2169245 D hypothetical protein 2168940..2169245 Mycobacterium leprae Br4923 7327325 YP_002503847.1 CDS MLBr_01794 NC_011896.1 2171439 2172647 D aminotransferase 2171439..2172647 Mycobacterium leprae Br4923 7325882 YP_002503848.1 CDS hsp18 NC_011896.1 2174224 2174670 D hypothetical protein 2174224..2174670 Mycobacterium leprae Br4923 7325883 YP_002503849.1 CDS MLBr_01796 NC_011896.1 2175229 2175642 D hypothetical protein 2175229..2175642 Mycobacterium leprae Br4923 7324697 YP_002503850.1 CDS MLBr_01798 NC_011896.1 2176846 2177829 R functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase complement(2176846..2177829) Mycobacterium leprae Br4923 7325395 YP_002503851.1 CDS mutB NC_011896.1 2177830 2180106 R MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase complement(2177830..2180106) Mycobacterium leprae Br4923 7325885 YP_002503852.1 CDS mutA NC_011896.1 2180112 2182022 R methylmalonyl-CoA mutase subunit beta complement(2180112..2182022) Mycobacterium leprae Br4923 7324943 YP_002503853.1 CDS MLBr_01802 NC_011896.1 2183122 2184246 R hypothetical protein complement(2183122..2184246) Mycobacterium leprae Br4923 7325886 YP_002503854.1 CDS MLBr_01803 NC_011896.1 2184283 2184714 R hypothetical protein complement(2184283..2184714) Mycobacterium leprae Br4923 7325887 YP_002503855.1 CDS MLBr_01804 NC_011896.1 2184772 2185668 D hypothetical protein 2184772..2185668 Mycobacterium leprae Br4923 7325888 YP_002503856.1 CDS hemH NC_011896.1 2185705 2186715 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(2185705..2186715) Mycobacterium leprae Br4923 7325889 YP_002503857.1 CDS inhA NC_011896.1 2186722 2187531 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(2186722..2187531) Mycobacterium leprae Br4923 7324677 YP_002503858.1 CDS fabG1 NC_011896.1 2187561 2188322 R 3-oxoacyl-ACP reductase complement(2187561..2188322) Mycobacterium leprae Br4923 7324720 YP_002503859.1 CDS MLBr_01808 NC_011896.1 2188395 2189402 R hypothetical protein complement(2188395..2189402) Mycobacterium leprae Br4923 7325233 YP_002503860.1 CDS MLBr_01809 NC_011896.1 2189446 2190408 R hypothetical protein complement(2189446..2190408) Mycobacterium leprae Br4923 7325890 YP_002503861.1 CDS moxR NC_011896.1 2190405 2191538 R MoxR complement(2190405..2191538) Mycobacterium leprae Br4923 7325891 YP_002503862.1 CDS MLBr_01811 NC_011896.1 2191773 2192498 R hypothetical protein complement(2191773..2192498) Mycobacterium leprae Br4923 7324923 YP_002503863.1 CDS MLBr_01812 NC_011896.1 2192525 2193964 R hypothetical protein complement(2192525..2193964) Mycobacterium leprae Br4923 7325892 YP_002503864.1 CDS MLBr_01813 NC_011896.1 2194204 2194776 R hypothetical protein complement(2194204..2194776) Mycobacterium leprae Br4923 7325893 YP_002503865.1 CDS acn NC_011896.1 2195059 2197893 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 2195059..2197893 Mycobacterium leprae Br4923 7325894 YP_002503866.1 CDS MLBr_01816 NC_011896.1 2198882 2200519 R ABC transporter ATP-binding protein complement(2198882..2200519) Mycobacterium leprae Br4923 7325895 YP_002503867.1 CDS trxB NC_011896.1 2201448 2201840 R thioredoxin complement(2201448..2201840) Mycobacterium leprae Br4923 7326191 YP_002503868.1 CDS MLBr_01821 NC_011896.1 2204653 2205006 R hypothetical protein complement(2204653..2205006) Mycobacterium leprae Br4923 7325897 YP_002503869.1 CDS PPE NC_011896.1 2212373 2214091 R PPE family protein complement(2212373..2214091) Mycobacterium leprae Br4923 7326123 YP_002503870.1 CDS MLBr_01829 NC_011896.1 2214738 2215115 D hypothetical protein 2214738..2215115 Mycobacterium leprae Br4923 7325903 YP_002503871.1 CDS mapA NC_011896.1 2219327 2220127 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(2219327..2220127) Mycobacterium leprae Br4923 7325905 YP_002503872.1 CDS adk NC_011896.1 2220139 2220684 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(2220139..2220684) Mycobacterium leprae Br4923 7325436 YP_002503873.1 CDS secY NC_011896.1 2220681 2221997 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(2220681..2221997) Mycobacterium leprae Br4923 7327192 YP_002503874.1 CDS MLBr_01835 NC_011896.1 2223141 2223824 R hypothetical protein complement(2223141..2223824) Mycobacterium leprae Br4923 7325906 YP_002503875.1 CDS sppA NC_011896.1 2226861 2228669 R protease IV, signal peptide peptidase complement(2226861..2228669) Mycobacterium leprae Br4923 7325318 YP_002503876.1 CDS rplO NC_011896.1 2228905 2229345 R late assembly protein; 50S ribosomal protein L15 complement(2228905..2229345) Mycobacterium leprae Br4923 7326000 YP_002503877.1 CDS rpmD NC_011896.1 2229346 2229561 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(2229346..2229561) Mycobacterium leprae Br4923 7326653 YP_002503878.1 CDS rpsE NC_011896.1 2229564 2230217 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(2229564..2230217) Mycobacterium leprae Br4923 7326667 YP_002503879.1 CDS rplR NC_011896.1 2230246 2230611 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(2230246..2230611) Mycobacterium leprae Br4923 7326681 YP_002503880.1 CDS rplF NC_011896.1 2230617 2231156 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(2230617..2231156) Mycobacterium leprae Br4923 7326656 YP_002503881.1 CDS rpsH NC_011896.1 2231182 2231580 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(2231182..2231580) Mycobacterium leprae Br4923 7326646 YP_002503882.1 CDS rpsN NC_011896.1 2231663 2231848 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 complement(2231663..2231848) Mycobacterium leprae Br4923 7325948 YP_002503883.1 CDS rplE NC_011896.1 2231854 2232417 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(2231854..2232417) Mycobacterium leprae Br4923 7325954 YP_002503884.1 CDS rplX NC_011896.1 2232418 2232735 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(2232418..2232735) Mycobacterium leprae Br4923 7326645 YP_002503885.1 CDS rplN NC_011896.1 2232736 2233077 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(2232736..2233077) Mycobacterium leprae Br4923 7326662 YP_002503886.1 CDS rpsQ NC_011896.1 2238274 2238657 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(2238274..2238657) Mycobacterium leprae Br4923 7327253 YP_002503887.1 CDS rpmC NC_011896.1 2238654 2238899 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(2238654..2238899) Mycobacterium leprae Br4923 7325957 YP_002503888.1 CDS rplP NC_011896.1 2238896 2239312 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(2238896..2239312) Mycobacterium leprae Br4923 7326666 YP_002503889.1 CDS rpsC NC_011896.1 2239316 2240161 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(2239316..2240161) Mycobacterium leprae Br4923 7326654 YP_002503890.1 CDS rplV NC_011896.1 2240161 2240688 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(2240161..2240688) Mycobacterium leprae Br4923 7326679 YP_002503891.1 CDS rpsS NC_011896.1 2240685 2240966 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(2240685..2240966) Mycobacterium leprae Br4923 7326660 YP_002503892.1 CDS rplB NC_011896.1 2240990 2241832 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(2240990..2241832) Mycobacterium leprae Br4923 7325959 YP_002503893.1 CDS rplW NC_011896.1 2241862 2242164 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(2241862..2242164) Mycobacterium leprae Br4923 7326642 YP_002503894.1 CDS rplD NC_011896.1 2242164 2242856 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(2242164..2242856) Mycobacterium leprae Br4923 7326661 YP_002503895.1 CDS rplC NC_011896.1 2242856 2243512 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(2242856..2243512) Mycobacterium leprae Br4923 7326644 YP_002503896.1 CDS rpsJ NC_011896.1 2243525 2243830 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(2243525..2243830) Mycobacterium leprae Br4923 7326643 YP_002503897.1 CDS tuf NC_011896.1 2255715 2256905 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(2255715..2256905) Mycobacterium leprae Br4923 7325921 YP_002503898.1 CDS fusA NC_011896.1 2257014 2259119 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(2257014..2259119) Mycobacterium leprae Br4923 7327293 YP_002503899.1 CDS rpsG NC_011896.1 2259213 2259683 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(2259213..2259683) Mycobacterium leprae Br4923 7325322 YP_002503900.1 CDS rpsL NC_011896.1 2259683 2260057 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(2259683..2260057) Mycobacterium leprae Br4923 7326683 YP_002503901.1 CDS MLBr_01889 NC_011896.1 2268112 2268870 R Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV complement(2268112..2268870) Mycobacterium leprae Br4923 7325283 YP_002503902.1 CDS rpoC NC_011896.1 2269195 2273145 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(2269195..2273145) Mycobacterium leprae Br4923 7325927 YP_002503903.1 CDS rpoB NC_011896.1 2273194 2276730 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(2273194..2276730) Mycobacterium leprae Br4923 7326675 YP_002503904.1 CDS MLBr_01892 NC_011896.1 2277185 2278201 R ABC transporter ATP-binding protein complement(2277185..2278201) Mycobacterium leprae Br4923 7326674 YP_002503905.1 CDS rplL NC_011896.1 2280360 2280752 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(2280360..2280752) Mycobacterium leprae Br4923 7325930 YP_002503906.1 CDS rplJ NC_011896.1 2280788 2281321 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(2280788..2281321) Mycobacterium leprae Br4923 7326650 YP_002503907.1 CDS MLBr_01898 NC_011896.1 2282213 2283559 D hypothetical protein 2282213..2283559 Mycobacterium leprae Br4923 7325931 YP_002503908.1 CDS lipG NC_011896.1 2283559 2284473 D hydrolase 2283559..2284473 Mycobacterium leprae Br4923 7325932 YP_002503909.1 CDS mmaA1 NC_011896.1 2284531 2285391 D methyl mycolic acid synthase 1 2284531..2285391 Mycobacterium leprae Br4923 7325391 YP_002503910.1 CDS mmaA4 NC_011896.1 2287556 2288452 D methyl mycolic acid synthase 4 2287556..2288452 Mycobacterium leprae Br4923 7325934 YP_002503911.1 CDS rplA NC_011896.1 2290234 2290941 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(2290234..2290941) Mycobacterium leprae Br4923 7324904 YP_002503912.1 CDS rplK NC_011896.1 2291073 2291501 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(2291073..2291501) Mycobacterium leprae Br4923 7326641 YP_002503913.1 CDS nusG NC_011896.1 2291529 2292215 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(2291529..2292215) Mycobacterium leprae Br4923 7326649 YP_002503914.1 CDS secE NC_011896.1 2292293 2292733 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(2292293..2292733) Mycobacterium leprae Br4923 7327336 YP_002503915.1 CDS MLBr_01908 NC_011896.1 2293069 2293569 R functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC complement(2293069..2293569) Mycobacterium leprae Br4923 7327286 YP_002503916.1 CDS MLBr_01909 NC_011896.1 2293573 2294001 R functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB complement(2293573..2294001) Mycobacterium leprae Br4923 7325935 YP_002503917.1 CDS MLBr_01910 NC_011896.1 2293988 2294467 R functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA complement(2293988..2294467) Mycobacterium leprae Br4923 7325936 YP_002503918.1 CDS rpmG NC_011896.1 2294514 2294681 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(2294514..2294681) Mycobacterium leprae Br4923 7325937 YP_002503919.1 CDS MLBr_01911A NC_011896.1 2295081 2295296 R hypothetical protein complement(2295081..2295296) Mycobacterium leprae Br4923 7326022 YP_002503920.1 CDS MLBr_01912 NC_011896.1 2295449 2296165 D glyoxylase 2295449..2296165 Mycobacterium leprae Br4923 7325938 YP_002503921.1 CDS MLBr_01915 NC_011896.1 2298396 2298740 D hypothetical protein 2298396..2298740 Mycobacterium leprae Br4923 7325420 YP_002503922.1 CDS MLBr_01918 NC_011896.1 2301760 2302551 R hypothetical protein complement(2301760..2302551) Mycobacterium leprae Br4923 7325942 YP_002503923.1 CDS MLBr_01919 NC_011896.1 2302690 2303331 R carbonic anhydrase complement(2302690..2303331) Mycobacterium leprae Br4923 7325943 YP_002503924.1 CDS mutY NC_011896.1 2303330 2304223 D DNA glycosylase 2303330..2304223 Mycobacterium leprae Br4923 7325944 YP_002503925.1 CDS MLBr_01921 NC_011896.1 2304232 2305002 R hypothetical protein complement(2304232..2305002) Mycobacterium leprae Br4923 7324946 YP_002503926.1 CDS MLBr_01922 NC_011896.1 2305128 2305445 D hypothetical protein 2305128..2305445 Mycobacterium leprae Br4923 7325945 YP_002503927.1 CDS lpqF NC_011896.1 2305420 2306784 D hypothetical protein 2305420..2306784 Mycobacterium leprae Br4923 7325946 YP_002503928.1 CDS sodC NC_011896.1 2310696 2311418 R superoxide dismutase (Cu-Zn) complement(2310696..2311418) Mycobacterium leprae Br4923 7325947 YP_002503929.1 CDS MLBr_01926 NC_011896.1 2311483 >2311986 R tuberculin related peptide complement(2311483..>2311986) Mycobacterium leprae Br4923 7325998 YP_002503930.1 CDS MLBr_01927 NC_011896.1 2312017 2312325 R hypothetical protein complement(2312017..2312325) Mycobacterium leprae Br4923 7325541 YP_002503931.1 CDS MLBr_01928 NC_011896.1 2312356 2312493 R hypothetical protein complement(2312356..2312493) Mycobacterium leprae Br4923 7325542 YP_002503932.1 CDS def NC_011896.1 2312540 2313133 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 2312540..2313133 Mycobacterium leprae Br4923 7325543 YP_002503933.1 CDS MLBr_01932 NC_011896.1 2314746 2315159 D hypothetical protein 2314746..2315159 Mycobacterium leprae Br4923 7327323 YP_002503934.1 CDS MLBr_01936 NC_011896.1 2322124 2323194 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(2322124..2323194) Mycobacterium leprae Br4923 7324994 YP_002503935.1 CDS MLBr_01937 NC_011896.1 2323245 2324477 D integral membrane protein 2323245..2324477 Mycobacterium leprae Br4923 7325547 YP_002503936.1 CDS ispH NC_011896.1 2324488 2325495 R catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase complement(2324488..2325495) Mycobacterium leprae Br4923 7325548 YP_002503937.1 CDS MLBr_01939 NC_011896.1 2325664 2326281 D hypothetical protein 2325664..2326281 Mycobacterium leprae Br4923 7325434 YP_002503938.1 CDS xseA NC_011896.1 2326278 2327564 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2326278..2327564 Mycobacterium leprae Br4923 7325549 YP_002503939.1 CDS xseB NC_011896.1 2327554 2327817 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 2327554..2327817 Mycobacterium leprae Br4923 7327321 YP_002503940.1 CDS MLBr_01942 NC_011896.1 2327868 2328998 D cholesterol dehydrogenase 2327868..2328998 Mycobacterium leprae Br4923 7327322 YP_002503941.1 CDS MLBr_01945 NC_011896.1 2331701 2332474 R hypothetical protein complement(2331701..2332474) Mycobacterium leprae Br4923 7325552 YP_002503942.1 CDS glpX NC_011896.1 2332554 2333540 D type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 2332554..2333540 Mycobacterium leprae Br4923 7325553 YP_002503943.1 CDS fumC NC_011896.1 2333549 2334973 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 2333549..2334973 Mycobacterium leprae Br4923 7325554 YP_002503944.1 CDS MLBr_01949 NC_011896.1 2336202 2336561 R hypothetical protein complement(2336202..2336561) Mycobacterium leprae Br4923 7325555 YP_002503945.1 CDS MLBr_01950 NC_011896.1 2336614 2337489 R carbohydrate degrading enzyme complement(2336614..2337489) Mycobacterium leprae Br4923 7325556 YP_002503946.1 CDS phoH2 NC_011896.1 2337544 2338845 R PhoH-like protein complement(2337544..2338845) Mycobacterium leprae Br4923 7325557 YP_002503947.1 CDS desA2 NC_011896.1 2339195 2340022 R acyl-[ACP] desaturase complement(2339195..2340022) Mycobacterium leprae Br4923 7327393 YP_002503948.1 CDS glyA NC_011896.1 2340079 2341359 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2340079..2341359) Mycobacterium leprae Br4923 7326168 YP_002503949.1 CDS coaA NC_011896.1 2341488 2342426 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 2341488..2342426 Mycobacterium leprae Br4923 7325371 YP_002503950.1 CDS truA NC_011896.1 2343254 2344003 R pseudouridylate synthase complement(2343254..2344003) Mycobacterium leprae Br4923 7326114 YP_002503951.1 CDS rplQ NC_011896.1 2344095 2344607 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(2344095..2344607) Mycobacterium leprae Br4923 7327287 YP_002503952.1 CDS rpoA NC_011896.1 2344631 2345674 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(2344631..2345674) Mycobacterium leprae Br4923 7326655 YP_002503953.1 CDS rpsD NC_011896.1 2345759 2346364 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(2345759..2346364) Mycobacterium leprae Br4923 7326673 YP_002503954.1 CDS rpsK NC_011896.1 2346398 2346814 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(2346398..2346814) Mycobacterium leprae Br4923 7326680 YP_002503955.1 CDS rpsM NC_011896.1 2346818 2347192 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(2346818..2347192) Mycobacterium leprae Br4923 7325951 YP_002503956.1 CDS rpmJ NC_011896.1 2347369 2347482 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(2347369..2347482) Mycobacterium leprae Br4923 7325953 YP_002503957.1 CDS infA NC_011896.1 2347522 2347743 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(2347522..2347743) Mycobacterium leprae Br4923 7326672 YP_002503958.1 CDS rmlB NC_011896.1 2348258 2349259 D dTDP-glucose 4,6-dehydratase 2348258..2349259 Mycobacterium leprae Br4923 7325558 YP_002503959.1 CDS rmlC NC_011896.1 2349261 2349869 D dTDP-4-dehydrorhamnose 3,5-epimerase 2349261..2349869 Mycobacterium leprae Br4923 7326628 YP_002503960.1 CDS lpqH NC_011896.1 2349914 2350399 D lipoprotein 2349914..2350399 Mycobacterium leprae Br4923 7326630 YP_002503961.1 CDS MLBr_01972 NC_011896.1 2356236 2356466 R hypothetical protein complement(2356236..2356466) Mycobacterium leprae Br4923 7325563 YP_002503962.1 CDS MLBr_01974 NC_011896.1 2358377 2360095 D permease 2358377..2360095 Mycobacterium leprae Br4923 7325565 YP_002503963.1 CDS MLBr_01976 NC_011896.1 2361144 2361491 R hypothetical protein complement(2361144..2361491) Mycobacterium leprae Br4923 7325567 YP_002503964.1 CDS MLBr_01979 NC_011896.1 2363859 2364266 R hypothetical protein complement(2363859..2364266) Mycobacterium leprae Br4923 7325230 YP_002503965.1 CDS MLBr_01982 NC_011896.1 2366522 2366830 D integral membrane protein 2366522..2366830 Mycobacterium leprae Br4923 7325571 YP_002503966.1 CDS MLBr_01983 NC_011896.1 2367343 2367810 D hypothetical protein 2367343..2367810 Mycobacterium leprae Br4923 7325572 YP_002503967.1 CDS aceA NC_011896.1 2369727 2372123 R isocitrate lyase complement(2369727..2372123) Mycobacterium leprae Br4923 7325574 YP_002503968.1 CDS ctpA NC_011896.1 2373352 2375652 D cation-transporting ATPase 2373352..2375652 Mycobacterium leprae Br4923 7325575 YP_002503969.1 CDS MLBr_01988 NC_011896.1 2375630 2376343 R integral membrane protein complement(2375630..2376343) Mycobacterium leprae Br4923 7326136 YP_002503970.1 CDS MLBr_01989 NC_011896.1 2376660 2377010 R hypothetical protein complement(2376660..2377010) Mycobacterium leprae Br4923 7325576 YP_002503971.1 CDS MLBr_01990 NC_011896.1 2377090 2377332 R integral membrane protein complement(2377090..2377332) Mycobacterium leprae Br4923 7325577 YP_002503972.1 CDS PPE NC_011896.1 2378419 2379825 D PPE family protein 2378419..2379825 Mycobacterium leprae Br4923 7325578 YP_002503973.1 CDS MLBr_01992 NC_011896.1 2379974 2380843 D oxidoreductase 2379974..2380843 Mycobacterium leprae Br4923 7324995 YP_002503974.1 CDS MLBr_01993 NC_011896.1 2380840 2381391 D hypothetical protein 2380840..2381391 Mycobacterium leprae Br4923 7325579 YP_002503975.1 CDS fadD10 NC_011896.1 2381421 2383019 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2381421..2383019 Mycobacterium leprae Br4923 7325580 YP_002503976.1 CDS MLBr_01995 NC_011896.1 2383012 2383248 D hypothetical protein 2383012..2383248 Mycobacterium leprae Br4923 7325244 YP_002503977.1 CDS nrp NC_011896.1 2383245 2387450 D peptide synthase 2383245..2387450 Mycobacterium leprae Br4923 7325581 YP_002503978.1 CDS MLBr_01997 NC_011896.1 2387457 2388089 R integral membrane protein complement(2387457..2388089) Mycobacterium leprae Br4923 7324968 YP_002503979.1 CDS MLBr_01998 NC_011896.1 2388202 2390181 D hypothetical protein 2388202..2390181 Mycobacterium leprae Br4923 7325582 YP_002503980.1 CDS ctpB NC_011896.1 2391242 2393494 R cation-transporting ATPase complement(2391242..2393494) Mycobacterium leprae Br4923 7325584 YP_002503981.1 CDS MLBr_02010 NC_011896.1 2402898 2403359 D lipoprotein 2402898..2403359 Mycobacterium leprae Br4923 7324724 YP_002503982.1 CDS aao NC_011896.1 2403414 2404376 D D-amino acid oxidase 2403414..2404376 Mycobacterium leprae Br4923 7325591 YP_002503983.1 CDS MLBr_02012 NC_011896.1 2404394 2404813 R hypothetical protein complement(2404394..2404813) Mycobacterium leprae Br4923 7327173 YP_002503984.1 CDS MLBr_02013 NC_011896.1 2405281 2405661 R hypothetical protein complement(2405281..2405661) Mycobacterium leprae Br4923 7325592 YP_002503985.1 CDS cinA NC_011896.1 2407225 2408523 R competence damage-inducible protein A complement(2407225..2408523) Mycobacterium leprae Br4923 7324951 YP_002503986.1 CDS MLBr_02020 NC_011896.1 2411240 2412154 D hypothetical protein 2411240..2412154 Mycobacterium leprae Br4923 7325595 YP_002503987.1 CDS MLBr_02022 NC_011896.1 2413569 2414093 R hypothetical protein complement(2413569..2414093) Mycobacterium leprae Br4923 7325597 YP_002503988.1 CDS MLBr_02023 NC_011896.1 2414189 2414593 R hypothetical protein complement(2414189..2414593) Mycobacterium leprae Br4923 7325598 YP_002503989.1 CDS fbpB NC_011896.1 2418545 2419528 D antigen 85A, mycolyltransferase 2418545..2419528 Mycobacterium leprae Br4923 7325603 YP_002503990.1 CDS MLBr_02030 NC_011896.1 2420572 2421045 D hypothetical protein 2420572..2421045 Mycobacterium leprae Br4923 7325604 YP_002503991.1 CDS MLBr_02031 NC_011896.1 2421076 2421531 D hypothetical protein 2421076..2421531 Mycobacterium leprae Br4923 7325605 YP_002503992.1 CDS MLBr_02035 NC_011896.1 2425091 2425354 R hypothetical protein complement(2425091..2425354) Mycobacterium leprae Br4923 7325608 YP_002503993.1 CDS bfrA NC_011896.1 2429248 2429727 R bacterioferritin complement(2429248..2429727) Mycobacterium leprae Br4923 7325351 YP_002503994.1 CDS oxyR NC_011896.1 2431909 2432844 R LysR family transcriptional regulator complement(2431909..2432844) Mycobacterium leprae Br4923 7325612 YP_002503995.1 CDS ahpC NC_011896.1 2432954 2433541 D alkyl hydroperoxide reductase 2432954..2433541 Mycobacterium leprae Br4923 7327343 YP_002503996.1 CDS MLBr_02044 NC_011896.1 2434293 2434514 R hypothetical protein complement(2434293..2434514) Mycobacterium leprae Br4923 7327196 YP_002503997.1 CDS MLBr_02045 NC_011896.1 2434923 2435180 D hypothetical protein 2434923..2435180 Mycobacterium leprae Br4923 7325613 YP_002503998.1 CDS lldD2 NC_011896.1 2435484 2436728 D L-lactate dehydrogenase 2435484..2436728 Mycobacterium leprae Br4923 7325614 YP_002503999.1 CDS MLBr_02048 NC_011896.1 2437730 2437987 D hypothetical protein 2437730..2437987 Mycobacterium leprae Br4923 7325615 YP_002504000.1 CDS MLBr_02053 NC_011896.1 2441022 2442029 R alcohol dehydrogenase complement(2441022..2442029) Mycobacterium leprae Br4923 7325620 YP_002504001.1 CDS MLBr_02054 NC_011896.1 2442107 2442406 R hypothetical protein complement(2442107..2442406) Mycobacterium leprae Br4923 7325621 YP_002504002.1 CDS modD NC_011896.1 2442566 2443429 R cell surface protein (associated with virulence) complement(2442566..2443429) Mycobacterium leprae Br4923 7325131 YP_002504003.1 CDS MLBr_02059 NC_011896.1 2446481 2447155 D short chain dehydrogenase 2446481..2447155 Mycobacterium leprae Br4923 7324916 YP_002504004.1 CDS MLBr_02061 NC_011896.1 2448347 2449747 D dehydrogenase 2448347..2449747 Mycobacterium leprae Br4923 7325133 YP_002504005.1 CDS MLBr_02063 NC_011896.1 2450581 2451009 D regulator 2450581..2451009 Mycobacterium leprae Br4923 7325135 YP_002504006.1 CDS MLBr_02064 NC_011896.1 2451014 2451964 D hypothetical protein 2451014..2451964 Mycobacterium leprae Br4923 7325136 YP_002504007.1 CDS gnd NC_011896.1 2452104 2453555 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2452104..2453555 Mycobacterium leprae Br4923 7325137 YP_002504008.1 CDS guaB1 NC_011896.1 2453625 2455061 D catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 2453625..2455061 Mycobacterium leprae Br4923 7324651 YP_002504009.1 CDS glcB NC_011896.1 2457921 2460116 D catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 2457921..2460116 Mycobacterium leprae Br4923 7325139 YP_002504010.1 CDS MLBr_02070 NC_011896.1 2460242 2462443 D hypothetical protein 2460242..2462443 Mycobacterium leprae Br4923 7325342 YP_002504011.1 CDS gcvB NC_011896.1 2463344 2466202 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(2463344..2466202) Mycobacterium leprae Br4923 7325141 YP_002504012.1 CDS MLBr_02073 NC_011896.1 2466370 2467065 R hypothetical protein complement(2466370..2467065) Mycobacterium leprae Br4923 7325336 YP_002504013.1 CDS MLBr_02074 NC_011896.1 2467298 2467792 R hypothetical protein complement(2467298..2467792) Mycobacterium leprae Br4923 7325142 YP_002504014.1 CDS MLBr_02075 NC_011896.1 2467909 2468664 R hypothetical protein complement(2467909..2468664) Mycobacterium leprae Br4923 7325143 YP_002504015.1 CDS MLBr_02076 NC_011896.1 2468661 2469149 R hypothetical protein complement(2468661..2469149) Mycobacterium leprae Br4923 7325144 YP_002504016.1 CDS gcvH NC_011896.1 2469393 2469791 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(2469393..2469791) Mycobacterium leprae Br4923 7325145 YP_002504017.1 CDS pgsA2 NC_011896.1 2472012 2472632 R CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2472012..2472632) Mycobacterium leprae Br4923 7325148 YP_002504018.1 CDS secA2 NC_011896.1 2472694 2475030 R SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(2472694..2475030) Mycobacterium leprae Br4923 7327387 YP_002504019.1 CDS ilvG NC_011896.1 2475138 2476784 R hypothetical protein complement(2475138..2476784) Mycobacterium leprae Br4923 7325974 YP_002504020.1 CDS MLBr_02084 NC_011896.1 2476878 2478794 D multidrug resistance pump 2476878..2478794 Mycobacterium leprae Br4923 7324713 YP_002504021.1 CDS MLBr_02088 NC_011896.1 2481469 2482773 R cytochrome p450 complement(2481469..2482773) Mycobacterium leprae Br4923 7325152 YP_002504022.1 CDS MLBr_02091 NC_011896.1 2487634 2487819 D hypothetical protein 2487634..2487819 Mycobacterium leprae Br4923 7325155 YP_002504023.1 CDS pstA1 NC_011896.1 2489056 2489970 R membrane-bound component of phosphate transport complement(2489056..2489970) Mycobacterium leprae Br4923 7325157 YP_002504024.1 CDS pstC2 NC_011896.1 2489988 2490947 R membrane-bound component of phosphate transport complement(2489988..2490947) Mycobacterium leprae Br4923 7325020 YP_002504025.1 CDS phoS2 NC_011896.1 2490990 2492099 R PstS component of phosphate uptake complement(2490990..2492099) Mycobacterium leprae Br4923 7325025 YP_002504026.1 CDS mntH NC_011896.1 2494427 2495707 D manganese transport protein MntH 2494427..2495707 Mycobacterium leprae Br4923 7325159 YP_002504027.1 CDS MLBr_02111 NC_011896.1 2512464 2512898 R hypothetical protein complement(2512464..2512898) Mycobacterium leprae Br4923 7325169 YP_002504028.1 CDS MLBr_02113 NC_011896.1 2513795 2514340 R hypothetical protein complement(2513795..2514340) Mycobacterium leprae Br4923 7325171 YP_002504029.1 CDS MLBr_02114 NC_011896.1 2514337 2514507 R hypothetical protein complement(2514337..2514507) Mycobacterium leprae Br4923 7325172 YP_002504030.1 CDS echA6 NC_011896.1 2518695 2519438 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2518695..2519438) Mycobacterium leprae Br4923 7325175 YP_002504031.1 CDS MLBr_02121 NC_011896.1 2521465 2521875 R hypothetical protein complement(2521465..2521875) Mycobacterium leprae Br4923 7325176 YP_002504032.1 CDS MLBr_02123 NC_011896.1 2524075 2524776 D two-component response regulator 2524075..2524776 Mycobacterium leprae Br4923 7325178 YP_002504033.1 CDS MLBr_02124 NC_011896.1 2524794 2526134 D sensor histidine kinase 2524794..2526134 Mycobacterium leprae Br4923 7325179 YP_002504034.1 CDS MLBr_02129 NC_011896.1 2530612 2530773 R PE-family protein (pseudogene); hypothetical protein complement(2530612..2530773) Mycobacterium leprae Br4923 7324996 YP_002504035.1 CDS gltA NC_011896.1 2531539 2532834 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(2531539..2532834) Mycobacterium leprae Br4923 7325183 YP_002504036.1 CDS pdxH NC_011896.1 2533083 2533703 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(2533083..2533703) Mycobacterium leprae Br4923 7325365 YP_002504037.1 CDS fprB NC_011896.1 2535738 2537405 R ferredoxin, ferredoxin-NADP reductase complement(2535738..2537405) Mycobacterium leprae Br4923 7325184 YP_002504038.1 CDS MLBr_02135 NC_011896.1 2537421 2538446 R transmembrane protein complement(2537421..2538446) Mycobacterium leprae Br4923 7325310 YP_002504039.1 CDS serC NC_011896.1 2538660 2539790 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 2538660..2539790 Mycobacterium leprae Br4923 7325185 YP_002504040.1 CDS MLBr_02137 NC_011896.1 2539908 2540663 D hypothetical protein 2539908..2540663 Mycobacterium leprae Br4923 7325980 YP_002504041.1 CDS MLBr_02140 NC_011896.1 2541910 2542341 R MarR-family protein complement(2541910..2542341) Mycobacterium leprae Br4923 7325188 YP_002504042.1 CDS MLBr_02141 NC_011896.1 2542545 2542820 D hypothetical protein 2542545..2542820 Mycobacterium leprae Br4923 7325189 YP_002504043.1 CDS MLBr_02142 NC_011896.1 2542932 2543741 R hypothetical protein complement(2542932..2543741) Mycobacterium leprae Br4923 7325190 YP_002504044.1 CDS MLBr_02143 NC_011896.1 2543851 2545590 D hypothetical protein 2543851..2545590 Mycobacterium leprae Br4923 7325191 YP_002504045.1 CDS MLBr_02144 NC_011896.1 2545598 2546086 D hypothetical protein 2545598..2546086 Mycobacterium leprae Br4923 7325192 YP_002504046.1 CDS cspB NC_011896.1 2551936 2552346 R cold shock protein complement(2551936..2552346) Mycobacterium leprae Br4923 7325263 YP_002504047.1 CDS MLBr_02151 NC_011896.1 2554670 2555194 D hypothetical protein 2554670..2555194 Mycobacterium leprae Br4923 7324914 YP_002504048.1 CDS MLBr_02155 NC_011896.1 2556641 2556865 R hypothetical protein complement(2556641..2556865) Mycobacterium leprae Br4923 7324913 YP_002504049.1 CDS MLBr_02156 NC_011896.1 2556963 2559224 D DNA-binding protein 2556963..2559224 Mycobacterium leprae Br4923 7325196 YP_002504050.1 CDS MLBr_02157 NC_011896.1 2559261 2560910 D DNA helicase 2559261..2560910 Mycobacterium leprae Br4923 7325197 YP_002504051.1 CDS MLBr_02158 NC_011896.1 2561022 2561414 R hypothetical protein complement(2561022..2561414) Mycobacterium leprae Br4923 7325198 YP_002504052.1 CDS fadB NC_011896.1 2569083 2571227 R fatty oxidation complex alpha subunit complement(2569083..2571227) Mycobacterium leprae Br4923 7325201 YP_002504053.1 CDS fadA NC_011896.1 2571232 2572443 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(2571232..2572443) Mycobacterium leprae Br4923 7325240 YP_002504054.1 CDS pdc NC_011896.1 2575887 2577596 D pyruvate (or indolepyruvate) decarboxylase 2575887..2577596 Mycobacterium leprae Br4923 7325204 YP_002504055.1 CDS MLBr_02170 NC_011896.1 2579131 2579355 R hypothetical protein complement(2579131..2579355) Mycobacterium leprae Br4923 7325253 YP_002504056.1 CDS MLBr_02172 NC_011896.1 2583169 2583525 D hypothetical protein 2583169..2583525 Mycobacterium leprae Br4923 7325207 YP_002504057.1 CDS cdd NC_011896.1 2586072 2586476 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2586072..2586476 Mycobacterium leprae Br4923 7325209 YP_002504058.1 CDS MLBr_02176 NC_011896.1 2588118 2588375 D hypothetical protein 2588118..2588375 Mycobacterium leprae Br4923 7325210 YP_002504059.1 CDS MLBr_02177 NC_011896.1 2588528 2589481 R uridine phosphorylase complement(2588528..2589481) Mycobacterium leprae Br4923 7325211 YP_002504060.1 CDS MLBr_02178 NC_011896.1 2589722 2589973 R hypothetical protein complement(2589722..2589973) Mycobacterium leprae Br4923 7325212 YP_002504061.1 CDS desA1 NC_011896.1 2599141 2600157 D acyl-[ACP] desaturase 2599141..2600157 Mycobacterium leprae Br4923 7324819 YP_002504062.1 CDS MLBr_02186 NC_011896.1 2600201 2601355 D NifR3/Smm1 family transcriptional regulator 2600201..2601355 Mycobacterium leprae Br4923 7326167 YP_002504063.1 CDS phoY1 NC_011896.1 2603503 2604171 D phosphate transport system regulator 2603503..2604171 Mycobacterium leprae Br4923 7324821 YP_002504064.1 CDS phoT NC_011896.1 2604198 2604974 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(2604198..2604974) Mycobacterium leprae Br4923 7327400 YP_002504065.1 CDS phoS3 NC_011896.1 2606756 2608045 R phosphate-binding protein 3 complement(2606756..2608045) Mycobacterium leprae Br4923 7325026 YP_002504066.1 CDS MLBr_02193 NC_011896.1 2608038 2608973 R acetyltransferase complement(2608038..2608973) Mycobacterium leprae Br4923 7327398 YP_002504067.1 CDS MLBr_02195 NC_011896.1 2609890 2610741 D hypothetical protein 2609890..2610741 Mycobacterium leprae Br4923 7324823 YP_002504068.1 CDS thiX NC_011896.1 2610834 2611256 D thiredoxin 2610834..2611256 Mycobacterium leprae Br4923 7324824 YP_002504069.1 CDS MLBr_02197 NC_011896.1 2611469 2611954 D hypothetical protein 2611469..2611954 Mycobacterium leprae Br4923 7326018 YP_002504070.1 CDS cysA3 NC_011896.1 2611986 2612819 D thiosulfate sulfurtransferase 2611986..2612819 Mycobacterium leprae Br4923 7324825 YP_002504071.1 CDS MLBr_02199 NC_011896.1 2612821 2613123 D hypothetical protein 2612821..2613123 Mycobacterium leprae Br4923 7326147 YP_002504072.1 CDS MLBr_02200 NC_011896.1 2613382 2614068 D hypothetical protein 2613382..2614068 Mycobacterium leprae Br4923 7324826 YP_002504073.1 CDS MLBr_02201 NC_011896.1 2615373 2615612 R hypothetical protein complement(2615373..2615612) Mycobacterium leprae Br4923 7324827 YP_002504074.1 CDS MLBr_02203 NC_011896.1 2617795 2618895 D hypothetical protein 2617795..2618895 Mycobacterium leprae Br4923 7327347 YP_002504075.1 CDS MLBr_02204 NC_011896.1 2619064 2619252 D hypothetical protein 2619064..2619252 Mycobacterium leprae Br4923 7324829 YP_002504076.1 CDS purM NC_011896.1 2619346 2620440 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(2619346..2620440) Mycobacterium leprae Br4923 7324830 YP_002504077.1 CDS purF NC_011896.1 2620540 2622210 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2620540..2622210) Mycobacterium leprae Br4923 7325041 YP_002504078.1 CDS MLBr_02207 NC_011896.1 2622222 2622617 R hypothetical protein complement(2622222..2622617) Mycobacterium leprae Br4923 7325037 YP_002504079.1 CDS cpsY NC_011896.1 2624249 2625877 D UDP-glucose-4-epimerase 2624249..2625877 Mycobacterium leprae Br4923 7325439 YP_002504080.1 CDS MLBr_02210 NC_011896.1 2625792 2626745 R hypothetical protein complement(2625792..2626745) Mycobacterium leprae Br4923 7326128 YP_002504081.1 CDS purL NC_011896.1 2626878 2629142 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II complement(2626878..2629142) Mycobacterium leprae Br4923 7324832 YP_002504082.1 CDS pepC NC_011896.1 2629994 2631325 R catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 2 complement(2629994..2631325) Mycobacterium leprae Br4923 7324833 YP_002504083.1 CDS purQ NC_011896.1 2635930 2636604 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I complement(2635930..2636604) Mycobacterium leprae Br4923 7324837 YP_002504084.1 CDS MLBr_02219A NC_011896.1 2636601 2636840 R With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS complement(2636601..2636840) Mycobacterium leprae Br4923 7325043 YP_002504085.1 CDS ptrB NC_011896.1 2642785 2644959 R protease II complement(2642785..2644959) Mycobacterium leprae Br4923 7324844 YP_002504086.1 CDS purC NC_011896.1 2644956 2645849 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2644956..2645849) Mycobacterium leprae Br4923 7325031 YP_002504087.1 CDS MLBr_02228 NC_011896.1 2645915 2646535 D hypothetical protein 2645915..2646535 Mycobacterium leprae Br4923 7325034 YP_002504088.1 CDS purB NC_011896.1 2647448 2648866 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(2647448..2648866) Mycobacterium leprae Br4923 7324846 YP_002504089.1 CDS purD NC_011896.1 2653262 2654530 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(2653262..2654530) Mycobacterium leprae Br4923 7325339 YP_002504090.1 CDS MLBr_02237 NC_011896.1 2656371 2656775 D hypothetical protein 2656371..2656775 Mycobacterium leprae Br4923 7324850 YP_002504091.1 CDS MLBr_02242 NC_011896.1 2660969 2661700 R hypothetical protein complement(2660969..2661700) Mycobacterium leprae Br4923 7327380 YP_002504092.1 CDS MLBr_02244 NC_011896.1 2667148 2667489 R hypothetical protein complement(2667148..2667489) Mycobacterium leprae Br4923 7324854 YP_002504093.1 CDS cpsA NC_011896.1 2670247 2671797 D hypothetical protein 2670247..2671797 Mycobacterium leprae Br4923 7324857 YP_002504094.1 CDS MLBr_02249 NC_011896.1 2672645 2672962 R hypothetical protein complement(2672645..2672962) Mycobacterium leprae Br4923 7324858 YP_002504095.1 CDS MLBr_02252 NC_011896.1 2675692 2675928 R hypothetical protein complement(2675692..2675928) Mycobacterium leprae Br4923 7325704 YP_002504096.1 CDS MLBr_02253 NC_011896.1 2676244 2676459 R antigen 84 complement(2676244..2676459) Mycobacterium leprae Br4923 7324861 YP_002504097.1 CDS otsA NC_011896.1 2677188 2678684 D trehalose-phosphate synthase 2677188..2678684 Mycobacterium leprae Br4923 7324862 YP_002504098.1 CDS menE NC_011896.1 2681302 2682408 R O-succinylbenzoic acid--CoA ligase complement(2681302..2682408) Mycobacterium leprae Br4923 7324864 YP_002504099.1 CDS MLBr_02258 NC_011896.1 2682453 2682755 R hypothetical protein complement(2682453..2682755) Mycobacterium leprae Br4923 7325449 YP_002504100.1 CDS MLBr_02259 NC_011896.1 2682785 2683075 R hypothetical protein complement(2682785..2683075) Mycobacterium leprae Br4923 7324865 YP_002504101.1 CDS pitA NC_011896.1 2683072 2684316 R low-affinity inorganic phosphate transporter complement(2683072..2684316) Mycobacterium leprae Br4923 7324866 YP_002504102.1 CDS MLBr_02261 NC_011896.1 2684414 2684830 R hypothetical protein complement(2684414..2684830) Mycobacterium leprae Br4923 7327401 YP_002504103.1 CDS menB NC_011896.1 2686484 2687386 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2686484..2687386) Mycobacterium leprae Br4923 7324868 YP_002504104.1 CDS MLBr_02264 NC_011896.1 2687383 2687994 R hypothetical protein complement(2687383..2687994) Mycobacterium leprae Br4923 7325447 YP_002504105.1 CDS MLBr_02265 NC_011896.1 2687987 2688208 R hypothetical protein complement(2687987..2688208) Mycobacterium leprae Br4923 7324869 YP_002504106.1 CDS MLBr_02268 NC_011896.1 2691722 2692726 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2691722..2692726 Mycobacterium leprae Br4923 7324871 YP_002504107.1 CDS MLBr_02269 NC_011896.1 2692689 2693486 D hydrolase 2692689..2693486 Mycobacterium leprae Br4923 7324872 YP_002504108.1 CDS menD NC_011896.1 2693730 2695400 D SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2693730..2695400 Mycobacterium leprae Br4923 7324873 YP_002504109.1 CDS MLBr_02271 NC_011896.1 2695428 2695955 D hypothetical protein 2695428..2695955 Mycobacterium leprae Br4923 7325448 YP_002504110.1 CDS ubiE NC_011896.1 2697208 2697924 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 2697208..2697924 Mycobacterium leprae Br4923 7324875 YP_002504111.1 CDS MLBr_02274 NC_011896.1 2697942 2698280 R hypothetical protein complement(2697942..2698280) Mycobacterium leprae Br4923 7324876 YP_002504112.1 CDS MLBr_02276 NC_011896.1 2698832 2700058 R FAD-linked oxidoreductase complement(2698832..2700058) Mycobacterium leprae Br4923 7324878 YP_002504113.1 CDS MLBr_02277 NC_011896.1 2700089 2701081 D polyprenyl diphosphate synthase component 2700089..2701081 Mycobacterium leprae Br4923 7324879 YP_002504114.1 CDS htpX NC_011896.1 2701192 2702055 D metalloprotease; heat shock protein HtpX 2701192..2702055 Mycobacterium leprae Br4923 7324880 YP_002504115.1 CDS MLBr_02279 NC_011896.1 2702583 2704073 R transmembrane transport protein complement(2702583..2704073) Mycobacterium leprae Br4923 7324700 YP_002504116.1 CDS MLBr_02283 NC_011896.1 2707657 2707971 D hypothetical protein 2707657..2707971 Mycobacterium leprae Br4923 7327295 YP_002504117.1 CDS MLBr_02284 NC_011896.1 2708363 2708722 D hypothetical protein 2708363..2708722 Mycobacterium leprae Br4923 7324885 YP_002504118.1 CDS MLBr_02288 NC_011896.1 2712361 2712585 R hypothetical protein complement(2712361..2712585) Mycobacterium leprae Br4923 7324889 YP_002504119.1 CDS MLBr_02289 NC_011896.1 2713333 2714103 R hypothetical protein complement(2713333..2714103) Mycobacterium leprae Br4923 7324890 YP_002504120.1 CDS MLBr_02295 NC_011896.1 2720481 2721185 R hypothetical protein complement(2720481..2721185) Mycobacterium leprae Br4923 7327187 YP_002504121.1 CDS MLBr_02296 NC_011896.1 2721389 2721934 D hypothetical protein 2721389..2721934 Mycobacterium leprae Br4923 7324893 YP_002504122.1 CDS MLBr_02297 NC_011896.1 2721935 2722909 D hydrolase 2721935..2722909 Mycobacterium leprae Br4923 7324894 YP_002504123.1 CDS MLBr_02298 NC_011896.1 2722902 2724107 R membrane-associated serine protease complement(2722902..2724107) Mycobacterium leprae Br4923 7327416 YP_002504124.1 CDS MLBr_02299 NC_011896.1 2724104 2724904 R hypothetical protein complement(2724104..2724904) Mycobacterium leprae Br4923 7326030 YP_002504125.1 CDS MLBr_02300 NC_011896.1 2724950 2725597 R hypothetical protein complement(2724950..2725597) Mycobacterium leprae Br4923 7326031 YP_002504126.1 CDS nth NC_011896.1 2725648 2726409 R endonuclease III complement(2725648..2726409) Mycobacterium leprae Br4923 7326032 YP_002504127.1 CDS MLBr_02302 NC_011896.1 2726835 2727509 D Crp/Fnr-family transcriptional regulator 2726835..2727509 Mycobacterium leprae Br4923 7327332 YP_002504128.1 CDS MLBr_02303 NC_011896.1 2727587 2728375 R hydrolase complement(2727587..2728375) Mycobacterium leprae Br4923 7326033 YP_002504129.1 CDS MLBr_02304 NC_011896.1 2728381 2728905 R hypothetical protein complement(2728381..2728905) Mycobacterium leprae Br4923 7326034 YP_002504130.1 CDS MLBr_02305 NC_011896.1 2729116 2730141 D anion transporter protein 2729116..2730141 Mycobacterium leprae Br4923 7326035 YP_002504131.1 CDS MLBr_02306 NC_011896.1 2730138 2731283 D anion transporter protein 2730138..2731283 Mycobacterium leprae Br4923 7326036 YP_002504132.1 CDS MLBr_02307 NC_011896.1 2731388 2731633 R hypothetical protein complement(2731388..2731633) Mycobacterium leprae Br4923 7326037 YP_002504133.1 CDS pon1 NC_011896.1 2732112 2734523 D penicillin binding protein (class A) 2732112..2734523 Mycobacterium leprae Br4923 7326038 YP_002504134.1 CDS MLBr_02309 NC_011896.1 2734712 2735704 D hypothetical protein 2734712..2735704 Mycobacterium leprae Br4923 7324981 YP_002504135.1 CDS MLBr_02312 NC_011896.1 2739846 2740436 D hypothetical protein 2739846..2740436 Mycobacterium leprae Br4923 7326041 YP_002504136.1 CDS MLBr_02313 NC_011896.1 2740870 2741472 D hypothetical protein 2740870..2741472 Mycobacterium leprae Br4923 7326042 YP_002504137.1 CDS glpK NC_011896.1 2741738 2743264 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2741738..2743264) Mycobacterium leprae Br4923 7326043 YP_002504138.1 CDS MLBr_02320 NC_011896.1 2747077 2747724 R hypothetical protein complement(2747077..2747724) Mycobacterium leprae Br4923 7324662 YP_002504139.1 CDS MLBr_02321 NC_011896.1 2750393 2751403 R hypothetical protein complement(2750393..2751403) Mycobacterium leprae Br4923 7326048 YP_002504140.1 CDS asd NC_011896.1 2751549 2752604 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(2751549..2752604) Mycobacterium leprae Br4923 7326049 YP_002504141.1 CDS ask NC_011896.1 2752604 2753869 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase complement(2752604..2753869) Mycobacterium leprae Br4923 7327239 YP_002504142.1 CDS leuA NC_011896.1 2754565 2756388 D 2-isopropylmalate synthase 2754565..2756388 Mycobacterium leprae Br4923 7327240 YP_002504143.1 CDS MLBr_02326 NC_011896.1 2757666 2758901 D ligase 2757666..2758901 Mycobacterium leprae Br4923 7326183 YP_002504144.1 CDS MLBr_02327 NC_011896.1 2758909 2759601 D hypothetical protein 2758909..2759601 Mycobacterium leprae Br4923 7326050 YP_002504145.1 CDS recR NC_011896.1 2760555 2761166 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(2760555..2761166) Mycobacterium leprae Br4923 7326052 YP_002504146.1 CDS MLBr_02330 NC_011896.1 2761178 2761528 R hypothetical protein complement(2761178..2761528) Mycobacterium leprae Br4923 7326613 YP_002504147.1 CDS MLBr_02331 NC_011896.1 2761628 2762398 D hypothetical protein 2761628..2762398 Mycobacterium leprae Br4923 7326053 YP_002504148.1 CDS MLBr_02332 NC_011896.1 2762414 2762851 R hypothetical protein complement(2762414..2762851) Mycobacterium leprae Br4923 7326054 YP_002504149.1 CDS MLBr_02333 NC_011896.1 2762940 2764319 D hypothetical protein 2762940..2764319 Mycobacterium leprae Br4923 7326055 YP_002504150.1 CDS MLBr_02334 NC_011896.1 2764373 2765635 D hypothetical protein 2764373..2765635 Mycobacterium leprae Br4923 7326056 YP_002504151.1 CDS dnaZX NC_011896.1 2765632 2767467 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(2765632..2767467) Mycobacterium leprae Br4923 7326057 YP_002504152.1 CDS MLBr_02336 NC_011896.1 2767577 2768968 R hypothetical protein complement(2767577..2768968) Mycobacterium leprae Br4923 7326184 YP_002504153.1 CDS MLBr_02337 NC_011896.1 2769367 2770119 D hypothetical protein 2769367..2770119 Mycobacterium leprae Br4923 7325984 YP_002504154.1 CDS MLBr_02341 NC_011896.1 2779402 2781600 R regulatory protein complement(2779402..2781600) Mycobacterium leprae Br4923 7326061 YP_002504155.1 CDS MLBr_02346 NC_011896.1 2786994 2787899 R hypothetical protein complement(2786994..2787899) Mycobacterium leprae Br4923 7326065 YP_002504156.1 CDS MLBr_02347 NC_011896.1 2788198 2789208 D hypothetical protein 2788198..2789208 Mycobacterium leprae Br4923 7326066 YP_002504157.1 CDS MLBr_02348 NC_011896.1 2789399 2790664 D glycosyl transferase family protein 2789399..2790664 Mycobacterium leprae Br4923 7326067 YP_002504158.1 CDS MLBr_02349 NC_011896.1 2790810 2792081 R required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase complement(2790810..2792081) Mycobacterium leprae Br4923 7326068 YP_002504159.1 CDS MLBr_02350 NC_011896.1 2792130 2792960 R antibiotic resistance membrane protein complement(2792130..2792960) Mycobacterium leprae Br4923 7326069 YP_002504160.1 CDS MLBr_02351 NC_011896.1 2792957 2793823 R antibiotic resistance membrane protein complement(2792957..2793823) Mycobacterium leprae Br4923 7326070 YP_002504161.1 CDS MLBr_02352 NC_011896.1 2793820 2794815 R antibiotic resistance efflux protein complement(2793820..2794815) Mycobacterium leprae Br4923 7326071 YP_002504162.1 CDS MLBr_02353 NC_011896.1 2794826 2799295 R polyketide synthase complement(2794826..2799295) Mycobacterium leprae Br4923 7326072 YP_002504163.1 CDS MLBr_02354 NC_011896.1 2799302 2804770 R polyketide synthase complement(2799302..2804770) Mycobacterium leprae Br4923 7326073 YP_002504164.1 CDS MLBr_02355 NC_011896.1 2804767 2811372 R polyketide synthase complement(2804767..2811372) Mycobacterium leprae Br4923 7326074 YP_002504165.1 CDS MLBr_02356 NC_011896.1 2811369 2815991 R polyketide synthase complement(2811369..2815991) Mycobacterium leprae Br4923 7326075 YP_002504166.1 CDS MLBr_02357 NC_011896.1 2815992 2821607 R polyketide synthase complement(2815992..2821607) Mycobacterium leprae Br4923 7326076 YP_002504167.1 CDS fadD26 NC_011896.1 2821604 2823355 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(2821604..2823355) Mycobacterium leprae Br4923 7326077 YP_002504168.1 CDS MLBr_02359 NC_011896.1 2824001 2824786 R thioesterase complement(2824001..2824786) Mycobacterium leprae Br4923 7325249 YP_002504169.1 CDS MLBr_02366 NC_011896.1 2834515 2834856 R hypothetical protein complement(2834515..2834856) Mycobacterium leprae Br4923 7325278 YP_002504170.1 CDS MLBr_02377 NC_011896.1 2846260 2846724 D hypothetical protein 2846260..2846724 Mycobacterium leprae Br4923 7326089 YP_002504171.1 CDS MLBr_02378 NC_011896.1 2846721 2849600 D hypothetical protein 2846721..2849600 Mycobacterium leprae Br4923 7326090 YP_002504172.1 CDS MLBr_02379 NC_011896.1 2849774 2850103 R hypothetical protein complement(2849774..2850103) Mycobacterium leprae Br4923 7326091 YP_002504173.1 CDS MLBr_02380 NC_011896.1 2850377 2850838 R hypothetical protein complement(2850377..2850838) Mycobacterium leprae Br4923 7326092 YP_002504174.1 CDS lpd NC_011896.1 2856775 2858178 D E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 2856775..2858178 Mycobacterium leprae Br4923 7326098 YP_002504175.1 CDS MLBr_02388 NC_011896.1 2858196 2858501 D hypothetical protein 2858196..2858501 Mycobacterium leprae Br4923 7325404 YP_002504176.1 CDS MLBr_02390 NC_011896.1 2861195 2861500 R hypothetical protein complement(2861195..2861500) Mycobacterium leprae Br4923 7326100 YP_002504177.1 CDS MLBr_02391 NC_011896.1 2861497 2862369 R hypothetical protein complement(2861497..2862369) Mycobacterium leprae Br4923 7326101 YP_002504178.1 CDS MLBr_02392 NC_011896.1 2862474 2862908 D hypothetical protein 2862474..2862908 Mycobacterium leprae Br4923 7326102 YP_002504179.1 CDS greA NC_011896.1 2863132 2863626 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 2863132..2863626 Mycobacterium leprae Br4923 7326103 YP_002504180.1 CDS metB NC_011896.1 2863689 2864855 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(2863689..2864855) Mycobacterium leprae Br4923 7324657 YP_002504181.1 CDS Ag36 NC_011896.1 2864935 2865684 R hypothetical protein complement(2864935..2865684) Mycobacterium leprae Br4923 7325453 YP_002504182.1 CDS cysM2 NC_011896.1 2865834 2867228 R cystathionine beta-synthase complement(2865834..2867228) Mycobacterium leprae Br4923 7327193 YP_002504183.1 CDS MLBr_02400 NC_011896.1 2870547 2871404 R transmembrane protein complement(2870547..2871404) Mycobacterium leprae Br4923 7325238 YP_002504184.1 CDS MLBr_02401 NC_011896.1 2871664 2872701 D catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 2871664..2872701 Mycobacterium leprae Br4923 7326105 YP_002504185.1 CDS MLBr_02402 NC_011896.1 2872726 2873499 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2872726..2873499 Mycobacterium leprae Br4923 7326106 YP_002504186.1 CDS MLBr_02406 NC_011896.1 2877293 2878177 D catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 2877293..2878177 Mycobacterium leprae Br4923 7324976 YP_002504187.1 CDS MLBr_02407 NC_011896.1 2878245 2878580 R hypothetical protein complement(2878245..2878580) Mycobacterium leprae Br4923 7326109 YP_002504188.1 CDS MLBr_02409 NC_011896.1 2879936 2880919 R cytochrome C biogenesis protein complement(2879936..2880919) Mycobacterium leprae Br4923 7327415 YP_002504189.1 CDS MLBr_02410 NC_011896.1 2880916 2882544 R hypothetical protein complement(2880916..2882544) Mycobacterium leprae Br4923 7324732 YP_002504190.1 CDS MLBr_02411 NC_011896.1 2882541 2883329 R cytochrome C-type biogenesis protein complement(2882541..2883329) Mycobacterium leprae Br4923 7324733 YP_002504191.1 CDS MLBr_02412 NC_011896.1 2883326 2883994 R hypothetical protein complement(2883326..2883994) Mycobacterium leprae Br4923 7324734 YP_002504192.1 CDS MLBr_02413 NC_011896.1 2883991 2884599 R phosphoglycerate mutase complement(2883991..2884599) Mycobacterium leprae Br4923 7324735 YP_002504193.1 CDS hemL NC_011896.1 2884599 2885939 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(2884599..2885939) Mycobacterium leprae Br4923 7324736 YP_002504194.1 CDS hemB NC_011896.1 2893697 2894686 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(2893697..2894686) Mycobacterium leprae Br4923 7324739 YP_002504195.1 CDS hemD NC_011896.1 2894733 2896424 R uroporphyrin-III C-methyltransferase complement(2894733..2896424) Mycobacterium leprae Br4923 7324671 YP_002504196.1 CDS hemC NC_011896.1 2896431 2897387 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(2896431..2897387) Mycobacterium leprae Br4923 7324673 YP_002504197.1 CDS hemA NC_011896.1 2897392 2898795 R catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase complement(2897392..2898795) Mycobacterium leprae Br4923 7324672 YP_002504198.1 CDS MLBr_02424 NC_011896.1 2899897 2900799 D hypothetical protein 2899897..2900799 Mycobacterium leprae Br4923 7324740 YP_002504199.1 CDS MLBr_02425 NC_011896.1 2900903 2901403 D hypothetical protein 2900903..2901403 Mycobacterium leprae Br4923 7324741 YP_002504200.1 CDS cmaA2 NC_011896.1 2901414 2902340 D cyclopropane mycolic acid synthase 2901414..2902340 Mycobacterium leprae Br4923 7324742 YP_002504201.1 CDS MLBr_02427 NC_011896.1 2902369 2903481 R hypothetical protein complement(2902369..2903481) Mycobacterium leprae Br4923 7326112 YP_002504202.1 CDS MLBr_02428 NC_011896.1 2903478 2904572 R glucose epimerase/dehydratase complement(2903478..2904572) Mycobacterium leprae Br4923 7324743 YP_002504203.1 CDS MLBr_02428A NC_011896.1 2904643 2904744 R hypothetical protein complement(2904643..2904744) Mycobacterium leprae Br4923 7324744 YP_002504204.1 CDS MLBr_02429 NC_011896.1 2904987 2905247 R DNA-binding protein complement(2904987..2905247) Mycobacterium leprae Br4923 7324745 YP_002504205.1 CDS proC NC_011896.1 2905388 2906272 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(2905388..2906272) Mycobacterium leprae Br4923 7324746 YP_002504206.1 CDS MLBr_02432 NC_011896.1 2907033 2907875 R hypothetical protein complement(2907033..2907875) Mycobacterium leprae Br4923 7324747 YP_002504207.1 CDS MLBr_02433 NC_011896.1 2907906 2908973 R hypothetical protein complement(2907906..2908973) Mycobacterium leprae Br4923 7324748 YP_002504208.1 CDS MLBr_02434 NC_011896.1 2908970 2909989 R hypothetical protein complement(2908970..2909989) Mycobacterium leprae Br4923 7324749 YP_002504209.1 CDS MLBr_02435 NC_011896.1 2910093 2910926 D hypothetical protein 2910093..2910926 Mycobacterium leprae Br4923 7324750 YP_002504210.1 CDS MLBr_02439 NC_011896.1 2914387 2914983 R two-component system response regulator complement(2914387..2914983) Mycobacterium leprae Br4923 7324754 YP_002504211.1 CDS MLBr_02440 NC_011896.1 2915026 2916351 R two-component system sensor histidine kinase complement(2915026..2916351) Mycobacterium leprae Br4923 7324755 YP_002504212.1 CDS gpmA NC_011896.1 2916514 2917257 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(2916514..2917257) Mycobacterium leprae Br4923 7324756 YP_002504213.1 CDS MLBr_02442 NC_011896.1 2917270 2917824 R hypothetical protein complement(2917270..2917824) Mycobacterium leprae Br4923 7324655 YP_002504214.1 CDS MLBr_02443 NC_011896.1 2917898 2919184 R glycosyl transferase family protein complement(2917898..2919184) Mycobacterium leprae Br4923 7324757 YP_002504215.1 CDS MLBr_02446 NC_011896.1 2921281 2922606 R lipoprotein complement(2921281..2922606) Mycobacterium leprae Br4923 7324760 YP_002504216.1 CDS murB NC_011896.1 2922687 2923790 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(2922687..2923790) Mycobacterium leprae Br4923 7324761 YP_002504217.1 CDS MLBr_02449 NC_011896.1 2924539 2925354 D hydrolase 2924539..2925354 Mycobacterium leprae Br4923 7324762 YP_002504218.1 CDS MLBr_02450 NC_011896.1 2925660 2926397 D hypothetical protein 2925660..2926397 Mycobacterium leprae Br4923 7324763 YP_002504219.1 CDS deoC NC_011896.1 2926454 2927134 R catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase complement(2926454..2927134) Mycobacterium leprae Br4923 7324764 YP_002504220.1 CDS MLBr_02452 NC_011896.1 2927134 2927505 R hypothetical protein complement(2927134..2927505) Mycobacterium leprae Br4923 7326165 YP_002504221.1 CDS MLBr_02453 NC_011896.1 2927608 2927895 R hypothetical protein complement(2927608..2927895) Mycobacterium leprae Br4923 7324765 YP_002504222.1 CDS MLBr_02454 NC_011896.1 2928015 2928581 R hemagglutinin complement(2928015..2928581) Mycobacterium leprae Br4923 7324766 YP_002504223.1 CDS MLBr_02457 NC_011896.1 2930076 2930777 D TetR family transcriptional regulator 2930076..2930777 Mycobacterium leprae Br4923 7324769 YP_002504224.1 CDS umaA2 NC_011896.1 2931960 2932847 D Mycolic acid synthase 2931960..2932847 Mycobacterium leprae Br4923 7324771 YP_002504225.1 CDS fadB2 NC_011896.1 2933984 2934847 R converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase complement(2933984..2934847) Mycobacterium leprae Br4923 7327298 YP_002504226.1 CDS MLBr_02463 NC_011896.1 2936649 2937443 R hypothetical protein complement(2936649..2937443) Mycobacterium leprae Br4923 7324704 YP_002504227.1 CDS MLBr_02465 NC_011896.1 2939075 2939641 D hypothetical protein 2939075..2939641 Mycobacterium leprae Br4923 7324773 YP_002504228.1 CDS MLBr_02467 NC_011896.1 2940802 2941590 D UDP pyrophosphate synthetase 2940802..2941590 Mycobacterium leprae Br4923 7324775 YP_002504229.1 CDS MLBr_02468 NC_011896.1 2941925 2942305 R hypothetical protein complement(2941925..2942305) Mycobacterium leprae Br4923 7324776 YP_002504230.1 CDS MLBr_02472 NC_011896.1 2947033 2948016 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(2947033..2948016) Mycobacterium leprae Br4923 7324778 YP_002504231.1 CDS MLBr_02473 NC_011896.1 2948147 2948626 D hypothetical protein 2948147..2948626 Mycobacterium leprae Br4923 7324779 YP_002504232.1 CDS MLBr_02474 NC_011896.1 2948641 2949156 D cytidine/deoxycytidylate deaminase 2948641..2949156 Mycobacterium leprae Br4923 7324780 YP_002504233.1 CDS MLBr_02476 NC_011896.1 2950514 2950681 R hypothetical protein complement(2950514..2950681) Mycobacterium leprae Br4923 7324782 YP_002504234.1 CDS MLBr_02478 NC_011896.1 2952624 2953013 R hypothetical protein complement(2952624..2953013) Mycobacterium leprae Br4923 7324784 YP_002504235.1 CDS MLBr_02485 NC_011896.1 2959327 2959875 R RNA methyltransferase complement(2959327..2959875) Mycobacterium leprae Br4923 7324791 YP_002504236.1 CDS pyrE NC_011896.1 2960867 2961406 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(2960867..2961406) Mycobacterium leprae Br4923 7324793 YP_002504237.1 CDS MLBr_02489 NC_011896.1 2962142 2963002 R hypothetical protein complement(2962142..2963002) Mycobacterium leprae Br4923 7324795 YP_002504238.1 CDS clpB NC_011896.1 2963087 2965633 R heat shock protein complement(2963087..2965633) Mycobacterium leprae Br4923 7324796 YP_002504239.1 CDS MLBr_02491 NC_011896.1 2966564 2967565 D hypothetical protein 2966564..2967565 Mycobacterium leprae Br4923 7327273 YP_002504240.1 CDS hspR NC_011896.1 2969165 2969563 R heat shock regulator complement(2969165..2969563) Mycobacterium leprae Br4923 7324798 YP_002504241.1 CDS dnaJ NC_011896.1 2969567 2970733 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ complement(2969567..2970733) Mycobacterium leprae Br4923 7324698 YP_002504242.1 CDS grpE NC_011896.1 2970747 2971436 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2970747..2971436) Mycobacterium leprae Br4923 7326179 YP_002504243.1 CDS dnaK NC_011896.1 2971433 2973295 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(2971433..2973295) Mycobacterium leprae Br4923 7324661 YP_002504244.1 CDS MLBr_02497 NC_011896.1 2973984 2974457 D hypothetical protein 2973984..2974457 Mycobacterium leprae Br4923 7326181 YP_002504245.1 CDS MLBr_02498 NC_011896.1 2974487 2975146 D enoyl-CoA hydratase 2974487..2975146 Mycobacterium leprae Br4923 7324799 YP_002504246.1 CDS MLBr_02501 NC_011896.1 2980048 2982690 D iron-sulfur-binding reductase 2980048..2982690 Mycobacterium leprae Br4923 7324802 YP_002504247.1 CDS MLBr_02502 NC_011896.1 2982699 2984012 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2982699..2984012 Mycobacterium leprae Br4923 7324803 YP_002504248.1 CDS rfbA NC_011896.1 2984167 2985033 R glucose-1-phosphate thymidylyltransferase complement(2984167..2985033) Mycobacterium leprae Br4923 7324804 YP_002504249.1 CDS dcd NC_011896.1 2987816 2988388 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2987816..2988388) Mycobacterium leprae Br4923 7327296 YP_002504250.1 CDS MLBr_02518 NC_011896.1 2999683 3000075 R hypothetical protein complement(2999683..3000075) Mycobacterium leprae Br4923 7325461 YP_002504251.1 CDS MLBr_02522 NC_011896.1 3004457 3005113 R hypothetical protein complement(3004457..3005113) Mycobacterium leprae Br4923 7325465 YP_002504252.1 CDS MLBr_02527 NC_011896.1 3009123 3010142 R hypothetical protein complement(3009123..3010142) Mycobacterium leprae Br4923 7325469 YP_002504253.1 CDS MLBr_02528 NC_011896.1 3010139 3011566 R protease complement(3010139..3011566) Mycobacterium leprae Br4923 7325470 YP_002504254.1 CDS MLBr_02529 NC_011896.1 3011577 3013034 R hypothetical protein complement(3011577..3013034) Mycobacterium leprae Br4923 7325471 YP_002504255.1 CDS MLBr_02530 NC_011896.1 3013176 3014045 R DNA-binding protein complement(3013176..3014045) Mycobacterium leprae Br4923 7325472 YP_002504256.1 CDS MLBr_02531 NC_011896.1 3014056 3014346 R cell surface protein complement(3014056..3014346) Mycobacterium leprae Br4923 7325473 YP_002504257.1 CDS MLBr_02532 NC_011896.1 3014385 3014681 R PE-family protein complement(3014385..3014681) Mycobacterium leprae Br4923 7325474 YP_002504258.1 CDS MLBr_02534 NC_011896.1 3015970 3016278 R PE-family protein complement(3015970..3016278) Mycobacterium leprae Br4923 7327370 YP_002504259.1 CDS MLBr_02535 NC_011896.1 3016313 3020302 R hypothetical protein complement(3016313..3020302) Mycobacterium leprae Br4923 7325476 YP_002504260.1 CDS MLBr_02536 NC_011896.1 3020299 3021957 R hypothetical protein complement(3020299..3021957) Mycobacterium leprae Br4923 7325477 YP_002504261.1 CDS MLBr_02537 NC_011896.1 3021950 3023872 R hypothetical protein complement(3021950..3023872) Mycobacterium leprae Br4923 7325478 YP_002504262.1 CDS fadD2 NC_011896.1 3033527 3035173 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3033527..3035173) Mycobacterium leprae Br4923 7325281 YP_002504263.1 CDS MLBr_02549 NC_011896.1 3037405 3038073 D hypothetical protein 3037405..3038073 Mycobacterium leprae Br4923 7325296 YP_002504264.1 CDS MLBr_02550 NC_011896.1 3038095 3039012 D hypothetical protein 3038095..3039012 Mycobacterium leprae Br4923 7325486 YP_002504265.1 CDS aac NC_011896.1 3039059 3039607 D aminoglycoside 2'-N-acetyltransferase 3039059..3039607 Mycobacterium leprae Br4923 7325487 YP_002504266.1 CDS MLBr_02557 NC_011896.1 3049162 3049458 D hypothetical protein 3049162..3049458 Mycobacterium leprae Br4923 7324696 YP_002504267.1 CDS MLBr_02561 NC_011896.1 3053090 3053578 R oxidoreductase complement(3053090..3053578) Mycobacterium leprae Br4923 7325492 YP_002504268.1 CDS MLBr_02562 NC_011896.1 3054455 3054745 D hypothetical protein 3054455..3054745 Mycobacterium leprae Br4923 7325493 YP_002504269.1 CDS fadE5 NC_011896.1 3055097 3056932 D acyl-CoA dehydrogenase 3055097..3056932 Mycobacterium leprae Br4923 7325494 YP_002504270.1 CDS fadA2 NC_011896.1 3057354 3058727 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(3057354..3058727) Mycobacterium leprae Br4923 7325280 YP_002504271.1 CDS fabG NC_011896.1 3058832 3060196 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3058832..3060196 Mycobacterium leprae Br4923 7325237 YP_002504272.1 CDS MLBr_02566 NC_011896.1 3061237 3062139 D hypothetical protein 3061237..3062139 Mycobacterium leprae Br4923 7325234 YP_002504273.1 CDS MLBr_02567 NC_011896.1 3062248 3062727 D hypothetical protein 3062248..3062727 Mycobacterium leprae Br4923 7325495 YP_002504274.1 CDS MLBr_02568 NC_011896.1 3063130 3063756 R TetR family transcriptional regulator complement(3063130..3063756) Mycobacterium leprae Br4923 7325496 YP_002504275.1 CDS MLBr_02569 NC_011896.1 3063826 3064989 R glycosyl hydrolase complement(3063826..3064989) Mycobacterium leprae Br4923 7325497 YP_002504276.1 CDS MLBr_02569A NC_011896.1 3065136 3065309 D hypothetical protein 3065136..3065309 Mycobacterium leprae Br4923 7325498 YP_002504277.1 CDS MLBr_02570 NC_011896.1 3065425 3069642 D integral membrane protein 3065425..3069642 Mycobacterium leprae Br4923 7325499 YP_002504278.1 CDS gabD1 NC_011896.1 3072552 3073925 D NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 3072552..3073925 Mycobacterium leprae Br4923 7325501 YP_002504279.1 CDS MLBr_02580 NC_011896.1 3080043 3081197 R acyltransferase complement(3080043..3081197) Mycobacterium leprae Br4923 7325505 YP_002504280.1 CDS MLBr_02581 NC_011896.1 3081406 3082689 D integral membrane protein 3081406..3082689 Mycobacterium leprae Br4923 7325506 YP_002504281.1 CDS MLBr_02582 NC_011896.1 3082791 3084593 D hypothetical protein 3082791..3084593 Mycobacterium leprae Br4923 7325507 YP_002504282.1 CDS MLBr_02583 NC_011896.1 3084956 3086140 R glycosyl transferase family protein complement(3084956..3086140) Mycobacterium leprae Br4923 7325508 YP_002504283.1 CDS MLBr_02584 NC_011896.1 3086193 3087002 D hypothetical protein 3086193..3087002 Mycobacterium leprae Br4923 7325509 YP_002504284.1 CDS yrbE1A NC_011896.1 3090634 3091437 D hypothetical protein 3090634..3091437 Mycobacterium leprae Br4923 7325258 YP_002504285.1 CDS yrbE1B NC_011896.1 3091441 3092310 D hypothetical protein 3091441..3092310 Mycobacterium leprae Br4923 7327326 YP_002504286.1 CDS mce1A NC_011896.1 3092314 3093639 D cell invasion protein 3092314..3093639 Mycobacterium leprae Br4923 7327327 YP_002504287.1 CDS mce1B NC_011896.1 3093636 3094676 D hypothetical protein 3093636..3094676 Mycobacterium leprae Br4923 7325440 YP_002504288.1 CDS mce1C NC_011896.1 3094673 3096232 D hypothetical protein 3094673..3096232 Mycobacterium leprae Br4923 7325441 YP_002504289.1 CDS mce1D NC_011896.1 3096229 3097824 D hypothetical protein 3096229..3097824 Mycobacterium leprae Br4923 7325442 YP_002504290.1 CDS lprK NC_011896.1 3097821 3098999 D lipoprotein 3097821..3098999 Mycobacterium leprae Br4923 7325443 YP_002504291.1 CDS mce1F NC_011896.1 3098993 3100543 D hypothetical protein 3098993..3100543 Mycobacterium leprae Br4923 7325424 YP_002504292.1 CDS MLBr_02595 NC_011896.1 3100677 3101225 D hypothetical protein 3100677..3101225 Mycobacterium leprae Br4923 7325444 YP_002504293.1 CDS MLBr_02596 NC_011896.1 3101222 3102199 D hypothetical protein 3101222..3102199 Mycobacterium leprae Br4923 7325512 YP_002504294.1 CDS MLBr_02597 NC_011896.1 3102196 3102750 D hypothetical protein 3102196..3102750 Mycobacterium leprae Br4923 7325513 YP_002504295.1 CDS MLBr_02598 NC_011896.1 3102840 3103394 D hypothetical protein 3102840..3103394 Mycobacterium leprae Br4923 7325514 YP_002504296.1 CDS MLBr_02600 NC_011896.1 3104529 3105926 R hypothetical protein complement(3104529..3105926) Mycobacterium leprae Br4923 7325425 YP_002504297.1 CDS MLBr_02603 NC_011896.1 3107415 3108254 D hypothetical protein 3107415..3108254 Mycobacterium leprae Br4923 7325989 YP_002504298.1 CDS MLBr_02604 NC_011896.1 3108315 3109064 D hypothetical protein 3108315..3109064 Mycobacterium leprae Br4923 7325518 YP_002504299.1 CDS MLBr_02605 NC_011896.1 3109061 3109567 D hypothetical protein 3109061..3109567 Mycobacterium leprae Br4923 7325519 YP_002504300.1 CDS ilvD NC_011896.1 3112893 3114587 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(3112893..3114587) Mycobacterium leprae Br4923 7325521 YP_002504301.1 CDS MLBr_02609 NC_011896.1 3114651 3115058 D hypothetical protein 3114651..3115058 Mycobacterium leprae Br4923 7324711 YP_002504302.1 CDS MLBr_02613 NC_011896.1 3118634 3120637 R zinc metalloprotease complement(3118634..3120637) Mycobacterium leprae Br4923 7325525 YP_002504303.1 CDS MLBr_02614 NC_011896.1 3120697 3121371 D hypothetical protein 3120697..3121371 Mycobacterium leprae Br4923 7325526 YP_002504304.1 CDS MLBr_02615 NC_011896.1 3121368 3122057 D hypothetical protein 3121368..3122057 Mycobacterium leprae Br4923 7325527 YP_002504305.1 CDS MLBr_02616 NC_011896.1 3122136 3122648 R hypothetical protein complement(3122136..3122648) Mycobacterium leprae Br4923 7325528 YP_002504306.1 CDS MLBr_02617 NC_011896.1 3122645 3125686 R hypothetical protein complement(3122645..3125686) Mycobacterium leprae Br4923 7325529 YP_002504307.1 CDS MLBr_02618 NC_011896.1 3126303 3127361 R integral membrane protein complement(3126303..3127361) Mycobacterium leprae Br4923 7325530 YP_002504308.1 CDS MLBr_02620 NC_011896.1 3128702 3131569 R hypothetical protein complement(3128702..3131569) Mycobacterium leprae Br4923 7325532 YP_002504309.1 CDS MLBr_02621 NC_011896.1 3131649 3132236 R hypothetical protein complement(3131649..3132236) Mycobacterium leprae Br4923 7325533 YP_002504310.1 CDS trmB NC_011896.1 3132445 3133137 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3132445..3133137) Mycobacterium leprae Br4923 7325534 YP_002504311.1 CDS pckA NC_011896.1 3135143 3136972 D catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 3135143..3136972 Mycobacterium leprae Br4923 7325536 YP_002504312.1 CDS MLBr_02627 NC_011896.1 3140130 3141149 D hypothetical protein 3140130..3141149 Mycobacterium leprae Br4923 7325275 YP_002504313.1 CDS MLBr_02629 NC_011896.1 3144441 3144911 R hypothetical protein complement(3144441..3144911) Mycobacterium leprae Br4923 7325259 YP_002504314.1 CDS MLBr_02630 NC_011896.1 3145095 3145466 R hypothetical protein complement(3145095..3145466) Mycobacterium leprae Br4923 7325538 YP_002504315.1 CDS MLBr_02631 NC_011896.1 3147564 3148913 R oxidoreductase complement(3147564..3148913) Mycobacterium leprae Br4923 7325539 YP_002504316.1 CDS pntB NC_011896.1 3151333 3152751 R pyridine transhydrogenase subunit beta complement(3151333..3152751) Mycobacterium leprae Br4923 7327114 YP_002504317.1 CDS pntAB NC_011896.1 3152748 3153086 R pyridine transhydrogenase subunit alpha2 complement(3152748..3153086) Mycobacterium leprae Br4923 7324979 YP_002504318.1 CDS pntAA NC_011896.1 3153079 3154182 R pyridine transhydrogenase subunit alpha1 complement(3153079..3154182) Mycobacterium leprae Br4923 7324978 YP_002504319.1 CDS MLBr_02639 NC_011896.1 3157231 3158736 R aldehyde dehydrogenase complement(3157231..3158736) Mycobacterium leprae Br4923 7327115 YP_002504320.1 CDS MLBr_02640 NC_011896.1 3158924 3159856 R hypothetical protein complement(3158924..3159856) Mycobacterium leprae Br4923 7327116 YP_002504321.1 CDS MLBr_02647 NC_011896.1 3166734 3167267 D this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 3166734..3167267 Mycobacterium leprae Br4923 7327123 YP_002504322.1 CDS MLBr_02649 NC_011896.1 3169193 3170008 R hypothetical protein complement(3169193..3170008) Mycobacterium leprae Br4923 7327125 YP_002504323.1 CDS MLBr_02651 NC_011896.1 3173158 3173475 D hypothetical protein 3173158..3173475 Mycobacterium leprae Br4923 7327127 YP_002504324.1 CDS MLBr_02654 NC_011896.1 3176596 3177093 D hypothetical protein 3176596..3177093 Mycobacterium leprae Br4923 7327130 YP_002504325.1 CDS fbpC2 NC_011896.1 3177682 3178683 D antigen 85A, mycolyltransferase 3177682..3178683 Mycobacterium leprae Br4923 7327131 YP_002504326.1 CDS MLBr_02659 NC_011896.1 3181943 3183007 R serine protease complement(3181943..3183007) Mycobacterium leprae Br4923 7327134 YP_002504327.1 CDS MLBr_02661 NC_011896.1 3185729 3187375 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3185729..3187375) Mycobacterium leprae Br4923 7325323 YP_002504328.1 CDS oxyS NC_011896.1 3189244 3190176 R LysR family transcriptional regulator complement(3189244..3190176) Mycobacterium leprae Br4923 7327342 YP_002504329.1 CDS MLBr_02664 NC_011896.1 3190644 3191399 D hypothetical protein 3190644..3191399 Mycobacterium leprae Br4923 7327344 YP_002504330.1 CDS MLBr_02666 NC_011896.1 3193575 3193829 R hypothetical protein complement(3193575..3193829) Mycobacterium leprae Br4923 7327138 YP_002504331.1 CDS MLBr_02667 NC_011896.1 3194418 3196274 R membrane transport protein complement(3194418..3196274) Mycobacterium leprae Br4923 7327139 YP_002504332.1 CDS MLBr_02669 NC_011896.1 3197296 3197616 D hypothetical protein 3197296..3197616 Mycobacterium leprae Br4923 7327141 YP_002504333.1 CDS MLBr_02670 NC_011896.1 3197830 3199830 R hypothetical protein complement(3197830..3199830) Mycobacterium leprae Br4923 7327142 YP_002504334.1 CDS MLBr_02671 NC_011896.1 3204579 3209408 D cation transport ATPase 3204579..3209408 Mycobacterium leprae Br4923 7327143 YP_002504335.1 CDS icd2 NC_011896.1 3210516 3212756 R NADP; isocitrate dehydrogenase complement(3210516..3212756) Mycobacterium leprae Br4923 7327144 YP_002504336.1 CDS MLBr_02677 NC_011896.1 3221564 3222274 D TetR family transcriptional regulator 3221564..3222274 Mycobacterium leprae Br4923 7327147 YP_002504337.1 CDS MLBr_02678 NC_011896.1 3222271 3225273 D hypothetical protein 3222271..3225273 Mycobacterium leprae Br4923 7327148 YP_002504338.1 CDS MLBr_02679 NC_011896.1 3225270 3227951 D hypothetical protein 3225270..3227951 Mycobacterium leprae Br4923 7327149 YP_002504339.1 CDS dnaB NC_011896.1 3230183 3231997 R replicative DNA helicase complement(3230183..3231997) Mycobacterium leprae Br4923 7327150 YP_002504340.1 CDS rplI NC_011896.1 3232547 3233005 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(3232547..3233005) Mycobacterium leprae Br4923 7327151 YP_002504341.1 CDS rpsR NC_011896.1 3233053 3233307 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(3233053..3233307) Mycobacterium leprae Br4923 7326647 YP_002504342.1 CDS ssb NC_011896.1 3233333 3233839 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(3233333..3233839) Mycobacterium leprae Br4923 7325958 YP_002504343.1 CDS rpsF NC_011896.1 3233999 3234289 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(3233999..3234289) Mycobacterium leprae Br4923 7326001 YP_002504344.1 CDS MLBr_02687 NC_011896.1 3234837 3236531 R hypothetical protein complement(3234837..3236531) Mycobacterium leprae Br4923 7327152 YP_002504345.1 CDS ponA NC_011896.1 3236528 3238654 R penicillin-bonding protein complement(3236528..3238654) Mycobacterium leprae Br4923 7327153 YP_002504346.1 CDS MLBr_02689 NC_011896.1 3239052 3239468 R hypothetical protein complement(3239052..3239468) Mycobacterium leprae Br4923 7324982 YP_002504347.1 CDS MLBr_02691 NC_011896.1 3240667 3241209 D hypothetical protein 3240667..3241209 Mycobacterium leprae Br4923 7327155 YP_002504348.1 CDS MLBr_02692 NC_011896.1 3241290 3242399 D hypothetical protein 3241290..3242399 Mycobacterium leprae Br4923 7327156 YP_002504349.1 CDS MLBr_02696 NC_011896.1 3246650 3247381 D MarR-family regulatory protein 3246650..3247381 Mycobacterium leprae Br4923 7327160 YP_002504350.1 CDS pcnA NC_011896.1 3248136 3249596 R polynucleotide polymerase; pcnA complement(3248136..3249596) Mycobacterium leprae Br4923 7327161 YP_002504351.1 CDS MLBr_02698 NC_011896.1 3249783 3250538 D hypothetical protein 3249783..3250538 Mycobacterium leprae Br4923 7327358 YP_002504352.1 CDS MLBr_02699 NC_011896.1 3250535 3252928 D hypothetical protein 3250535..3252928 Mycobacterium leprae Br4923 7327162 YP_002504353.1 CDS MLBr_02700 NC_011896.1 3252925 3256545 D hypothetical protein 3252925..3256545 Mycobacterium leprae Br4923 7327163 YP_002504354.1 CDS trx NC_011896.1 3258118 3259494 D thioredoxin; bifunctional thioredoxin reductase/thioredoxin 3258118..3259494 Mycobacterium leprae Br4923 7327165 YP_002504355.1 CDS MLBr_02704 NC_011896.1 3259627 3260847 D hydrolase 3259627..3260847 Mycobacterium leprae Br4923 7327289 YP_002504356.1 CDS MLBr_02705 NC_011896.1 3260844 3261623 R hypothetical protein complement(3260844..3261623) Mycobacterium leprae Br4923 7327166 YP_002504357.1 CDS parB NC_011896.1 3261976 3262983 R cell division protein complement(3261976..3262983) Mycobacterium leprae Br4923 7327167 YP_002504358.1 CDS parA NC_011896.1 3262980 3264035 R cell division protein complement(3262980..3264035) Mycobacterium leprae Br4923 7327353 YP_002504359.1 CDS gidB NC_011896.1 3264032 3264778 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(3264032..3264778) Mycobacterium leprae Br4923 7327352 YP_002504360.1 CDS MLBr_02709 NC_011896.1 3264850 3265431 R hypothetical protein complement(3264850..3265431) Mycobacterium leprae Br4923 7327168 YP_002504361.1 CDS MLBr_02710 NC_011896.1 3265513 3266655 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC complement(3265513..3266655) Mycobacterium leprae Br4923 7327169 YP_002504362.1 CDS rnpA NC_011896.1 3266994 3267356 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(3266994..3267356) Mycobacterium leprae Br4923 7327171 YP_002504363.1 CDS rpmH NC_011896.1 3267378 3267521 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(3267378..3267521) Mycobacterium leprae Br4923 7326634 MLBr_t01 tRNA ileT NC_011896.1 12194 12270 D tRNA-Ile 12194..12270 Mycobacterium leprae Br4923 7327010 MLBr_t02 tRNA alaT NC_011896.1 12404 12479 D tRNA-Ala 12404..12479 Mycobacterium leprae Br4923 7324707 MLBr_t03 tRNA leuT NC_011896.1 28886 28968 D tRNA-Leu 28886..28968 Mycobacterium leprae Br4923 7327019 MLBr_t04 tRNA serU NC_011896.1 160339 160428 D tRNA-Ser 160339..160428 Mycobacterium leprae Br4923 7325844 MLBr_t05 tRNA serT NC_011896.1 165062 165154 D tRNA-Ser 165062..165154 Mycobacterium leprae Br4923 7324681 MLBr_t06 tRNA argU NC_011896.1 165174 165246 D tRNA-Arg 165174..165246 Mycobacterium leprae Br4923 7325982 MLBr_t07 tRNA alaV NC_011896.1 251320 251392 D tRNA-Ala 251320..251392 Mycobacterium leprae Br4923 7326293 MLBr_t08 tRNA thrU NC_011896.1 271916 271991 D tRNA-Thr 271916..271991 Mycobacterium leprae Br4923 7326305 MLBr_t09 tRNA glnT NC_011896.1 326148 326219 R tRNA-Gln complement(326148..326219) Mycobacterium leprae Br4923 7325348 MLBr_t10 tRNA leuX NC_011896.1 344356 344429 D tRNA-Leu 344356..344429 Mycobacterium leprae Br4923 7327365 MLBr_t11 tRNA lysU NC_011896.1 524684 524759 R tRNA-Lys complement(524684..524759) Mycobacterium leprae Br4923 7325633 MLBr_t12 tRNA hisT NC_011896.1 526177 526252 R tRNA-His complement(526177..526252) Mycobacterium leprae Br4923 7325411 MLBr_t13 tRNA metU NC_011896.1 780293 780369 D tRNA-Met 780293..780369 Mycobacterium leprae Br4923 7326988 MLBr_t14 tRNA asnT NC_011896.1 990887 990959 D tRNA-Asn 990887..990959 Mycobacterium leprae Br4923 7325061 MLBr_t15 tRNA argV NC_011896.1 1316340 1316415 R tRNA-Arg complement(1316340..1316415) Mycobacterium leprae Br4923 7326592 MLBr_t16 tRNA leuW NC_011896.1 1374116 1374198 D tRNA-Leu 1374116..1374198 Mycobacterium leprae Br4923 7327051 MLBr_t17 tRNA argW NC_011896.1 1481472 1481545 R tRNA-Arg complement(1481472..1481545) Mycobacterium leprae Br4923 7327093 MLBr_t18 tRNA leuV NC_011896.1 1531720 1531796 R tRNA-Leu complement(1531720..1531796) Mycobacterium leprae Br4923 7326441 MLBr_t19 tRNA leuU NC_011896.1 1535974 1536059 R tRNA-Leu complement(1535974..1536059) Mycobacterium leprae Br4923 7326443 MLBr_t20 tRNA valU NC_011896.1 1602309 1602383 R tRNA-Val complement(1602309..1602383) Mycobacterium leprae Br4923 7326487 MLBr_t21 tRNA cysU NC_011896.1 1602398 1602471 R tRNA-Cys complement(1602398..1602471) Mycobacterium leprae Br4923 7327312 MLBr_t22 tRNA glyT NC_011896.1 1602497 1602572 R tRNA-Gly complement(1602497..1602572) Mycobacterium leprae Br4923 7326156 MLBr_t23 tRNA valT NC_011896.1 1602751 1602825 D tRNA-Val 1602751..1602825 Mycobacterium leprae Br4923 7325373 MLBr_t24 tRNA proT NC_011896.1 1638299 1638375 D tRNA-Pro 1638299..1638375 Mycobacterium leprae Br4923 7326514 MLBr_t25 tRNA proU NC_011896.1 1784942 1785018 R tRNA-Pro complement(1784942..1785018) Mycobacterium leprae Br4923 7326904 MLBr_t26 tRNA glyV NC_011896.1 1785154 1785224 D tRNA-Gly 1785154..1785224 Mycobacterium leprae Br4923 7325013 MLBr_t27 tRNA valV NC_011896.1 1987167 1987241 R tRNA-Val complement(1987167..1987241) Mycobacterium leprae Br4923 7326770 MLBr_t28 tRNA gluU NC_011896.1 2033033 2033108 R tRNA-Glu complement(2033033..2033108) Mycobacterium leprae Br4923 7326791 MLBr_t29 tRNA glnU NC_011896.1 2033196 2033270 R tRNA-Gln complement(2033196..2033270) Mycobacterium leprae Br4923 7325370 MLBr_t30 tRNA alaU NC_011896.1 2133771 2133846 R tRNA-Ala complement(2133771..2133846) Mycobacterium leprae Br4923 7326837 MLBr_t31 tRNA metV NC_011896.1 2135421 2135494 R tRNA-Met complement(2135421..2135494) Mycobacterium leprae Br4923 7327385 MLBr_t32 tRNA trpT NC_011896.1 2292826 2292898 R tRNA-Trp complement(2292826..2292898) Mycobacterium leprae Br4923 7325976 MLBr_t33 tRNA metT NC_011896.1 2294725 2294801 R tRNA-Met complement(2294725..2294801) Mycobacterium leprae Br4923 7326670 MLBr_t34 tRNA thrT NC_011896.1 2294855 2294927 R tRNA-Thr complement(2294855..2294927) Mycobacterium leprae Br4923 7324813 MLBr_t35 tRNA argT NC_011896.1 2506526 2506598 D tRNA-Arg 2506526..2506598 Mycobacterium leprae Br4923 7325165 MLBr_t36 tRNA pheU NC_011896.1 2594509 2594585 R tRNA-Phe complement(2594509..2594585) Mycobacterium leprae Br4923 7324814 MLBr_t37 tRNA aspT NC_011896.1 2594614 2594690 R tRNA-Asp complement(2594614..2594690) Mycobacterium leprae Br4923 7327391 MLBr_t38 tRNA gluT NC_011896.1 2594721 2594793 R tRNA-Glu complement(2594721..2594793) Mycobacterium leprae Br4923 7327244 MLBr_t39 tRNA lysT NC_011896.1 2594917 2594989 D tRNA-Lys 2594917..2594989 Mycobacterium leprae Br4923 7325369 MLBr_t40 tRNA thrV NC_011896.1 2659617 2659691 D tRNA-Thr 2659617..2659691 Mycobacterium leprae Br4923 7324852 MLBr_t41 tRNA tyrT NC_011896.1 2707310 2707393 D tRNA-Tyr 2707310..2707393 Mycobacterium leprae Br4923 7324884 MLBr_t42 tRNA proY NC_011896.1 2736722 2736795 D tRNA-Pro 2736722..2736795 Mycobacterium leprae Br4923 7326040 MLBr_t43 tRNA serV NC_011896.1 2769178 2769263 D tRNA-Ser 2769178..2769263 Mycobacterium leprae Br4923 7326058 MLBr_t44 tRNA serX NC_011896.1 2949173 2949263 D tRNA-Ser 2949173..2949263 Mycobacterium leprae Br4923 7324781 MLBr_t45 tRNA glyU NC_011896.1 2989223 2989296 D tRNA-Gly 2989223..2989296 Mycobacterium leprae Br4923 7324808 MLBr_r1 rRNA MLBr_r1 NC_011896.1 1341184 1342740 D 16S ribosomal RNA 1341184..1342740 Mycobacterium leprae Br4923 9679867 MLBr_r2 rRNA MLBr_r2 NC_011896.1 1343021 1346135 D 23S ribosomal RNA join(1343021..1344573,1344632..1346135) Mycobacterium leprae Br4923 9679868 MLBr_r3 rRNA MLBr_r3 NC_011896.1 1346227 1346342 D 5S ribosomal RNA 1346227..1346342 Mycobacterium leprae Br4923 9679869