-- dump date 20140619_152949 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_301129.1 15826866 908143 1..1566 1 NC_002677.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 1566 dnaA 908143 dnaA Mycobacterium leprae TN chromosome replication initiator DnaA NP_301129.1 1 D 272631 CDS NP_301130.1 15826867 908144 2081..3280 1 NC_002677.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3280 dnaN 908144 dnaN Mycobacterium leprae TN DNA polymerase III subunit beta NP_301130.1 2081 D 272631 CDS NP_301131.1 15826868 910262 3281..4438 1 NC_002677.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4438 recF 910262 recF Mycobacterium leprae TN recombination protein F NP_301131.1 3281 D 272631 CDS NP_301132.1 15826869 910215 4435..5004 1 NC_002677.1 hypothetical protein 5004 910215 ML0004 Mycobacterium leprae TN hypothetical protein NP_301132.1 4435 D 272631 CDS NP_301133.1 15826870 908148 5229..7265 1 NC_002677.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 7265 gyrB 908148 gyrB Mycobacterium leprae TN DNA gyrase subunit B NP_301133.1 5229 D 272631 CDS NP_301134.1 15826871 908154 7318..11067 1 NC_002677.1 DNA gyrase subunit A 11067 gyrA 908154 gyrA Mycobacterium leprae TN DNA gyrase subunit A NP_301134.1 7318 D 272631 CDS NP_301135.1 15826872 908160 11195..12106 1 NC_002677.1 hypothetical protein 12106 908160 ML0007 Mycobacterium leprae TN hypothetical protein NP_301135.1 11195 D 272631 CDS NP_301136.1 15826873 908162 complement(12856..13230) 1 NC_002677.1 hypothetical protein 13230 908162 ML0008 Mycobacterium leprae TN hypothetical protein NP_301136.1 12856 R 272631 CDS NP_301137.1 15826874 908165 13775..13966 1 NC_002677.1 hypothetical protein 13966 908165 ML0009 Mycobacterium leprae TN hypothetical protein NP_301137.1 13775 D 272631 CDS NP_301138.1 15826875 908167 15993..16541 1 NC_002677.1 peptidyl-prolyl cis-trans isomerase 16541 ppiA 908167 ppiA Mycobacterium leprae TN peptidyl-prolyl cis-trans isomerase NP_301138.1 15993 D 272631 CDS NP_301139.1 15826876 908168 complement(16566..16979) 1 NC_002677.1 hypothetical protein 16979 908168 ML0012 Mycobacterium leprae TN hypothetical protein NP_301139.1 16566 R 272631 CDS NP_301140.1 15826877 909726 complement(17134..17415) 1 NC_002677.1 integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein 17415 909726 ML0013 Mycobacterium leprae TN septation inhibitor protein NP_301140.1 17134 R 272631 CDS NP_301141.1 15826878 910411 18325..19023 1 NC_002677.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 19023 pabA 910411 pabA Mycobacterium leprae TN para-aminobenzoate synthase component II NP_301141.1 18325 D 272631 CDS NP_301142.1 15826879 908655 complement(19001..20869) 1 NC_002677.1 serine/threonine protein kinase 20869 pknB 908655 pknB Mycobacterium leprae TN serine/threonine protein kinase NP_301142.1 19001 R 272631 CDS NP_301143.1 15826880 908171 complement(20879..22192) 1 NC_002677.1 serine/threonine protein kinase 22192 pknA 908171 pknA Mycobacterium leprae TN serine/threonine protein kinase NP_301143.1 20879 R 272631 CDS NP_301144.1 15826881 908172 complement(22189..23667) 1 NC_002677.1 penicillin-binding protein 23667 pbpA 908172 pbpA Mycobacterium leprae TN penicillin-binding protein NP_301144.1 22189 R 272631 CDS NP_301145.1 15826882 910311 complement(23664..25061) 1 NC_002677.1 cell-division protein 25061 rodA 910311 rodA Mycobacterium leprae TN cell-division protein NP_301145.1 23664 R 272631 CDS NP_301146.1 15826883 908178 complement(25058..26587) 1 NC_002677.1 hypothetical protein 26587 908178 ML0020 Mycobacterium leprae TN hypothetical protein NP_301146.1 25058 R 272631 CDS NP_301147.1 15826884 908179 complement(26584..27051) 1 NC_002677.1 hypothetical protein 27051 908179 ML0021 Mycobacterium leprae TN hypothetical protein NP_301147.1 26584 R 272631 CDS NP_301148.1 15826885 908180 complement(27173..28639) 1 NC_002677.1 hypothetical protein 28639 908180 ML0022 Mycobacterium leprae TN hypothetical protein NP_301148.1 27173 R 272631 CDS NP_301149.1 15826886 908183 complement(28954..29265) 1 NC_002677.1 hypothetical protein 29265 908183 ML0023 Mycobacterium leprae TN hypothetical protein NP_301149.1 28954 R 272631 CDS NP_301150.1 15826887 909248 29775..30026 1 NC_002677.1 hypothetical protein 30026 909248 ML0024 Mycobacterium leprae TN hypothetical protein NP_301150.1 29775 D 272631 CDS NP_301151.1 15826888 909233 complement(30293..30583) 1 NC_002677.1 hypothetical protein 30583 909233 ML0025 Mycobacterium leprae TN hypothetical protein NP_301151.1 30293 R 272631 CDS NP_301152.1 15826889 908188 33100..33705 1 NC_002677.1 hypothetical protein 33705 908188 ML0028 Mycobacterium leprae TN hypothetical protein NP_301152.1 33100 D 272631 CDS NP_301153.1 15826890 908189 complement(34033..34638) 1 NC_002677.1 hypothetical protein 34638 908189 ML0029 Mycobacterium leprae TN hypothetical protein NP_301153.1 34033 R 272631 CDS NP_301154.1 15826891 908190 complement(34750..35091) 1 NC_002677.1 hypothetical protein 35091 908190 ML0030 Mycobacterium leprae TN hypothetical protein NP_301154.1 34750 R 272631 CDS NP_301155.1 15826892 908191 complement(35287..36123) 1 NC_002677.1 Similar to M. tuberculosis MTC28, Rv0040c, proline rich 28 KDa antigen precursoR, SW:PR28_MYCTU (P71697) (311 aa); Fasta score E(): 0, 65.1% identity in 258 aa overlap. Previously sequenced as TR:O33075 (EMBL:Y14967) (278 aa); Fasta score E(): 0, 100.0% identity in 278 aa overlap. Contains a probable N-terminal signal sequence.; C-terminal half is similar to a region of ML0246; hypothetical protein 36123 908191 ML0031 Mycobacterium leprae TN hypothetical protein NP_301155.1 35287 R 272631 CDS NP_301156.1 15826893 908194 36321..39239 1 NC_002677.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 39239 leuS 908194 leuS Mycobacterium leprae TN leucyl-tRNA synthetase NP_301156.1 36321 D 272631 CDS NP_301157.1 15826894 908205 50656..51996 1 NC_002677.1 protease 51996 908205 ML0041 Mycobacterium leprae TN protease NP_301157.1 50656 D 272631 CDS NP_301158.1 15826895 908206 51993..53396 1 NC_002677.1 hypothetical protein 53396 908206 ML0042 Mycobacterium leprae TN hypothetical protein NP_301158.1 51993 D 272631 CDS NP_301159.1 15826896 908209 54698..55039 1 NC_002677.1 Similar to M. tuberculosis Rv3880c, hypothetical protein, TR:O69744 (EMBL:AL123456) (115 aa); Fasta score E(): 2.6e-21, 56.4% identity in 110 aa overlap. Previously sequenced as TR:O33080 (EMBL:Y14967) (113 aa); Fasta score E(): 0, 100.0% identity in 113 aa overlap.; hypothetical protein 55039 908209 ML0044 Mycobacterium leprae TN hypothetical protein NP_301159.1 54698 D 272631 CDS NP_301160.1 15826897 908667 complement(58020..59558) 1 NC_002677.1 hypothetical protein 59558 908667 ML0047 Mycobacterium leprae TN hypothetical protein NP_301160.1 58020 R 272631 CDS NP_301161.1 15826898 908679 complement(59555..61315) 1 NC_002677.1 hypothetical protein 61315 908679 ML0048 Mycobacterium leprae TN hypothetical protein NP_301161.1 59555 R 272631 CDS NP_301162.1 15826899 908212 complement(61406..61693) 1 NC_002677.1 hypothetical protein 61693 908212 ML0049 Mycobacterium leprae TN hypothetical protein NP_301162.1 61406 R 272631 CDS NP_301163.1 15826900 910497 complement(61720..62022) 1 NC_002677.1 hypothetical protein 62022 910497 ML0050 Mycobacterium leprae TN hypothetical protein NP_301163.1 61720 R 272631 CDS NP_301164.1 15826901 910495 complement(62201..63109) 1 NC_002677.1 PPE family protein 63109 910495 ML0051 Mycobacterium leprae TN PPE family protein NP_301164.1 62201 R 272631 CDS NP_301165.1 15826902 910515 complement(63319..65112) 1 NC_002677.1 hypothetical protein 65112 910515 ML0052 Mycobacterium leprae TN hypothetical protein NP_301165.1 63319 R 272631 CDS NP_301166.1 15826903 910139 complement(65186..67420) 1 NC_002677.1 hypothetical protein 67420 910139 ML0053 Mycobacterium leprae TN hypothetical protein NP_301166.1 65186 R 272631 CDS NP_301167.1 15826904 908215 complement(67417..68862) 1 NC_002677.1 hypothetical protein 68862 908215 ML0054 Mycobacterium leprae TN hypothetical protein NP_301167.1 67417 R 272631 CDS NP_301168.1 15826905 909371 complement(68866..70587) 1 NC_002677.1 hypothetical protein 70587 909371 ML0055 Mycobacterium leprae TN hypothetical protein NP_301168.1 68866 R 272631 CDS NP_301169.1 15826906 909016 complement(70584..71093) 1 NC_002677.1 hypothetical protein 71093 909016 ML0056 Mycobacterium leprae TN hypothetical protein NP_301169.1 70584 R 272631 CDS NP_301170.1 15826907 908217 77709..82292 1 NC_002677.1 ferredoxin-dependent glutamate synthase 82292 gltB 908217 gltB Mycobacterium leprae TN ferredoxin-dependent glutamate synthase NP_301170.1 77709 D 272631 CDS NP_301171.1 15826908 908220 82285..83751 1 NC_002677.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 83751 gltD 908220 gltD Mycobacterium leprae TN glutamate synthase subunit beta NP_301171.1 82285 D 272631 CDS NP_301172.1 15826909 908225 complement(85968..86612) 1 NC_002677.1 transcriptional regulator 86612 908225 ML0064 Mycobacterium leprae TN transcriptional regulator NP_301172.1 85968 R 272631 CDS NP_301173.1 15826910 908226 86681..88165 1 NC_002677.1 monooxygenase 88165 908226 ML0065 Mycobacterium leprae TN monooxygenase NP_301173.1 86681 D 272631 CDS NP_301174.1 15826911 908231 complement(88246..88719) 1 NC_002677.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 88719 menG 908231 menG Mycobacterium leprae TN ribonuclease activity regulator protein RraA NP_301174.1 88246 R 272631 CDS NP_301175.1 15826912 908182 complement(88741..89106) 1 NC_002677.1 histone-like protein 89106 hns 908182 hns Mycobacterium leprae TN histone-like protein NP_301175.1 88741 R 272631 CDS NP_301176.1 15826913 908647 complement(89620..90336) 1 NC_002677.1 hypothetical protein 90336 908647 ML0068 Mycobacterium leprae TN hypothetical protein NP_301176.1 89620 R 272631 CDS NP_301177.1 15826914 910469 complement(90521..90919) 1 NC_002677.1 hypothetical protein 90919 910469 ML0069 Mycobacterium leprae TN hypothetical protein NP_301177.1 90521 R 272631 CDS NP_301178.1 15826915 910479 complement(91296..91559) 1 NC_002677.1 hypothetical protein 91559 910479 ML0070 Mycobacterium leprae TN hypothetical protein NP_301178.1 91296 R 272631 CDS NP_301179.1 15826916 910383 complement(91913..92446) 1 NC_002677.1 hypothetical protein 92446 910383 ML0071 Mycobacterium leprae TN hypothetical protein NP_301179.1 91913 R 272631 CDS NP_301180.1 15826917 910514 complement(92647..93270) 1 NC_002677.1 superoxide dismutase 93270 sodA 910514 sodA Mycobacterium leprae TN superoxide dismutase NP_301180.1 92647 R 272631 CDS NP_301181.1 15826918 910182 94092..95126 1 NC_002677.1 hypothetical protein 95126 910182 ML0073 Mycobacterium leprae TN hypothetical protein NP_301181.1 94092 D 272631 CDS NP_301182.1 15826919 910167 95132..95947 1 NC_002677.1 glycerophosphoryl diester phosphodiesterase 95947 glpQ 910167 glpQ Mycobacterium leprae TN glycerophosphoryl diester phosphodiesterase NP_301182.1 95132 D 272631 CDS NP_301183.1 15826920 910395 98425..99393 1 NC_002677.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 99393 pheA 910395 pheA Mycobacterium leprae TN prephenate dehydratase NP_301183.1 98425 D 272631 CDS NP_301184.1 15826921 908234 99390..100085 1 NC_002677.1 phosphoglycerate mutase 100085 908234 ML0079 Mycobacterium leprae TN phosphoglycerate mutase NP_301184.1 99390 D 272631 CDS NP_301185.1 15826922 908237 complement(100648..102000) 1 NC_002677.1 hypothetical protein 102000 908237 ML0081 Mycobacterium leprae TN hypothetical protein NP_301185.1 100648 R 272631 CDS NP_301186.1 15826923 908238 102122..103375 1 NC_002677.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 103375 serS 908238 serS Mycobacterium leprae TN seryl-tRNA synthetase NP_301186.1 102122 D 272631 CDS NP_301187.1 15826924 910442 109049..109822 1 NC_002677.1 acyltransferase 109822 910442 ML0087 Mycobacterium leprae TN acyltransferase NP_301187.1 109049 D 272631 CDS NP_301188.1 15826925 908245 110329..111174 1 NC_002677.1 hypothetical protein 111174 908245 ML0089 Mycobacterium leprae TN hypothetical protein NP_301188.1 110329 D 272631 CDS NP_301189.1 15826926 908705 complement(113153..113863) 1 NC_002677.1 hypothetical protein 113863 908705 ML0091 Mycobacterium leprae TN hypothetical protein NP_301189.1 113153 R 272631 CDS NP_301190.1 15826927 908271 114130..115371 1 NC_002677.1 UDP-galactopyranose mutase 115371 glf 908271 glf Mycobacterium leprae TN UDP-galactopyranose mutase NP_301190.1 114130 D 272631 CDS NP_301191.1 15826928 908272 115371..117302 1 NC_002677.1 hypothetical protein 117302 908272 ML0093 Mycobacterium leprae TN hypothetical protein NP_301191.1 115371 D 272631 CDS NP_301192.1 15826929 908276 117295..117873 1 NC_002677.1 hypothetical protein 117873 908276 ML0094 Mycobacterium leprae TN hypothetical protein NP_301192.1 117295 D 272631 CDS NP_301193.1 15826930 908286 117870..118778 1 NC_002677.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 118778 908286 ML0095 Mycobacterium leprae TN phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase NP_301193.1 117870 D 272631 CDS NP_301194.1 15826931 909286 118819..120768 1 NC_002677.1 hypothetical protein 120768 909286 ML0096 Mycobacterium leprae TN hypothetical protein NP_301194.1 118819 D 272631 CDS NP_301195.1 15826932 908289 121157..122149 1 NC_002677.1 antigen 85A, mycolytransferase 122149 fbpA 908289 fbpA Mycobacterium leprae TN antigen 85A, mycolytransferase NP_301195.1 121157 D 272631 CDS NP_301196.1 15826933 908293 122310..123215 1 NC_002677.1 antigen 85C, mycolyltransferase 123215 fbpC 908293 fbpC Mycobacterium leprae TN antigen 85C, mycolyltransferase NP_301196.1 122310 D 272631 CDS NP_301197.1 15826934 908300 123370..124380 1 NC_002677.1 hypothetical protein 124380 908300 ML0099 Mycobacterium leprae TN hypothetical protein NP_301197.1 123370 D 272631 CDS NP_301198.1 15826935 908301 124599..126506 1 NC_002677.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 126506 fadD32 908301 fadD32 Mycobacterium leprae TN long-chain-fatty-acid--CoA ligase NP_301198.1 124599 D 272631 CDS NP_301199.1 15826936 908306 126518..131872 1 NC_002677.1 polyketide synthase 131872 pks13 908306 pks13 Mycobacterium leprae TN polyketide synthase NP_301199.1 126518 D 272631 CDS NP_301200.1 15826937 908326 131869..133422 1 NC_002677.1 acyl CoA carboxylase [beta] subunit 133422 accD4 908326 accD4 Mycobacterium leprae TN acyl CoA carboxylase [beta] subunit NP_301200.1 131869 D 272631 CDS NP_301201.1 15826938 908335 complement(136573..139824) 1 NC_002677.1 arabinosyltransferase 139824 embB 908335 embB Mycobacterium leprae TN arabinosyltransferase NP_301201.1 136573 R 272631 CDS NP_301202.1 15826939 908337 complement(139821..143156) 1 NC_002677.1 arabinosyltransferase 143156 embA 908337 embA Mycobacterium leprae TN arabinosyltransferase NP_301202.1 139821 R 272631 CDS NP_301203.1 15826940 908339 complement(144115..147327) 1 NC_002677.1 arabinosyltransferase 147327 embC 908339 embC Mycobacterium leprae TN arabinosyltransferase NP_301203.1 144115 R 272631 CDS NP_301204.1 15826941 908341 complement(147460..149358) 1 NC_002677.1 hypothetical protein 149358 908341 ML0107 Mycobacterium leprae TN hypothetical protein NP_301204.1 147460 R 272631 CDS NP_301205.1 15826942 908346 complement(149361..150125) 1 NC_002677.1 short chain dehydrogenase 150125 908346 ML0108 Mycobacterium leprae TN short chain dehydrogenase NP_301205.1 149361 R 272631 CDS NP_301206.1 15826943 908350 complement(150128..151510) 1 NC_002677.1 FAD-linked oxidoreductase 151510 908350 ML0109 Mycobacterium leprae TN FAD-linked oxidoreductase NP_301206.1 150128 R 272631 CDS NP_301207.1 15826944 908352 complement(151578..151949) 1 NC_002677.1 hypothetical protein 151949 908352 ML0110 Mycobacterium leprae TN hypothetical protein NP_301207.1 151578 R 272631 CDS NP_301208.1 15826945 908357 complement(152783..153613) 1 NC_002677.1 ABC transporter 153613 908357 ML0112 Mycobacterium leprae TN ABC transporter NP_301208.1 152783 R 272631 CDS NP_301209.1 15826946 908361 complement(153663..154514) 1 NC_002677.1 glycosyl transferase family protein 154514 rfbE 908361 rfbE Mycobacterium leprae TN glycosyl transferase family protein NP_301209.1 153663 R 272631 CDS NP_301210.1 15826947 908364 complement(154576..155394) 1 NC_002677.1 ABC transporter ATP-binding protein 155394 908364 ML0114 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301210.1 154576 R 272631 CDS NP_301211.1 15826948 908366 complement(155413..155937) 1 NC_002677.1 hypothetical protein 155937 908366 ML0115 Mycobacterium leprae TN hypothetical protein NP_301211.1 155413 R 272631 CDS NP_301212.1 15826949 908368 complement(155965..157929) 1 NC_002677.1 hypothetical protein 157929 908368 ML0116 Mycobacterium leprae TN hypothetical protein NP_301212.1 155965 R 272631 CDS NP_301213.1 15826950 908375 158056..159252 1 NC_002677.1 hypothetical protein 159252 908375 ML0117 Mycobacterium leprae TN hypothetical protein NP_301213.1 158056 D 272631 CDS NP_301214.1 15826951 908376 complement(159249..160259) 1 NC_002677.1 oxidireductase 160259 908376 ML0118 Mycobacterium leprae TN oxidireductase NP_301214.1 159249 R 272631 CDS NP_301215.1 15826952 908384 complement(160495..161730) 1 NC_002677.1 hydrolase 161730 lipE 908384 lipE Mycobacterium leprae TN hydrolase NP_301215.1 160495 R 272631 CDS NP_301216.1 15826953 908388 complement(161741..162577) 1 NC_002677.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 162577 echA1 908388 echA1 Mycobacterium leprae TN enoyl-CoA hydratase NP_301216.1 161741 R 272631 CDS NP_301217.1 15826954 908392 complement(163770..164039) 1 NC_002677.1 hypothetical protein 164039 908392 ML0121 Mycobacterium leprae TN hypothetical protein NP_301217.1 163770 R 272631 CDS NP_301218.1 15826955 908405 complement(166949..167389) 1 NC_002677.1 hypothetical protein 167389 908405 ML0124 Mycobacterium leprae TN hypothetical protein NP_301218.1 166949 R 272631 CDS NP_301219.1 15826956 908406 167598..168914 1 NC_002677.1 glycosyl transferase family protein 168914 908406 ML0125 Mycobacterium leprae TN glycosyl transferase family protein NP_301219.1 167598 D 272631 CDS NP_301220.1 15826957 908419 169585..170406 1 NC_002677.1 hypothetical protein 170406 908419 ML0126 Mycobacterium leprae TN hypothetical protein NP_301220.1 169585 D 272631 CDS NP_301221.1 15826958 908423 170662..171351 1 NC_002677.1 hypothetical protein 171351 908423 ML0127 Mycobacterium leprae TN hypothetical protein NP_301221.1 170662 D 272631 CDS NP_301222.1 15826959 908425 171616..172923 1 NC_002677.1 glycosyl transferase family protein 172923 908425 ML0128 Mycobacterium leprae TN glycosyl transferase family protein NP_301222.1 171616 D 272631 CDS NP_301223.1 15826960 908431 complement(173170..174426) 1 NC_002677.1 hypothetical protein 174426 908431 ML0129 Mycobacterium leprae TN hypothetical protein NP_301223.1 173170 R 272631 CDS NP_301224.1 15826961 908432 complement(174466..175278) 1 NC_002677.1 hypothetical protein 175278 908432 ML0130 Mycobacterium leprae TN hypothetical protein NP_301224.1 174466 R 272631 CDS NP_301225.1 15826962 908434 175441..176589 1 NC_002677.1 oxidoreductase 176589 908434 ML0131 Mycobacterium leprae TN oxidoreductase NP_301225.1 175441 D 272631 CDS NP_301226.2 161723272 908436 177464..179212 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 179212 fadD29 908436 fadD29 Mycobacterium leprae TN acyl-CoA synthetase NP_301226.2 177464 D 272631 CDS NP_301227.1 15826964 908439 179256..179888 1 NC_002677.1 hypothetical protein 179888 908439 ML0133 Mycobacterium leprae TN hypothetical protein NP_301227.1 179256 D 272631 CDS NP_301228.1 15826965 908446 180027..182150 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 182150 fadD22 908446 fadD22 Mycobacterium leprae TN acyl-CoA synthetase NP_301228.1 180027 D 272631 CDS NP_301229.1 15826966 908453 182173..188484 1 NC_002677.1 polyketide synthase 188484 908453 ML0135 Mycobacterium leprae TN polyketide synthase NP_301229.1 182173 D 272631 CDS NP_301230.1 15826967 908464 188551..189252 1 NC_002677.1 lipoprotein 189252 lppX 908464 lppX Mycobacterium leprae TN lipoprotein NP_301230.1 188551 D 272631 CDS NP_301231.1 15826968 908466 complement(189253..191961) 1 NC_002677.1 hypothetical protein 191961 mmpL7 908466 mmpL7 Mycobacterium leprae TN hypothetical protein NP_301231.1 189253 R 272631 CDS NP_301232.1 15826969 908470 complement(192013..193752) 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 193752 fadD28 908470 fadD28 Mycobacterium leprae TN acyl-CoA synthetase NP_301232.1 192013 R 272631 CDS NP_301233.1 15826970 908474 194221..200571 1 NC_002677.1 mycocerosic synthase 200571 mas 908474 mas Mycobacterium leprae TN mycocerosic synthase NP_301233.1 194221 D 272631 CDS NP_301234.1 15826971 908482 complement(202307..202561) 1 NC_002677.1 hypothetical protein 202561 908482 ML0141 Mycobacterium leprae TN hypothetical protein NP_301234.1 202307 R 272631 CDS NP_301235.1 15826972 908486 204363..204611 1 NC_002677.1 hypothetical protein 204611 908486 ML0142 Mycobacterium leprae TN hypothetical protein NP_301235.1 204363 D 272631 CDS NP_301236.1 15826973 908501 complement(211150..212814) 1 NC_002677.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 212814 pgi 908501 pgi Mycobacterium leprae TN glucose-6-phosphate isomerase NP_301236.1 211150 R 272631 CDS NP_301237.1 15826974 908503 complement(213175..213492) 1 NC_002677.1 hypothetical protein 213492 908503 ML0151 Mycobacterium leprae TN hypothetical protein NP_301237.1 213175 R 272631 CDS NP_301238.1 15826975 908504 214001..214189 1 NC_002677.1 hypothetical protein 214189 908504 ML0152 Mycobacterium leprae TN hypothetical protein NP_301238.1 214001 D 272631 CDS NP_301239.1 15826976 908505 214272..216608 1 NC_002677.1 ATP-dependent DNA helicase 216608 uvrD 908505 uvrD Mycobacterium leprae TN ATP-dependent DNA helicase NP_301239.1 214272 D 272631 CDS NP_301240.1 15826977 908508 complement(217160..218161) 1 NC_002677.1 hypothetical protein 218161 908508 ML0154 Mycobacterium leprae TN hypothetical protein NP_301240.1 217160 R 272631 CDS NP_301241.1 15826978 908509 218458..219639 1 NC_002677.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 219639 sucC 908509 sucC Mycobacterium leprae TN succinyl-CoA synthetase subunit beta NP_301241.1 218458 D 272631 CDS NP_301242.1 15826979 908514 219659..220561 1 NC_002677.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 220561 sucD 908514 sucD Mycobacterium leprae TN succinyl-CoA synthetase subunit alpha NP_301242.1 219659 D 272631 CDS NP_301243.1 15826980 908522 221657..222601 1 NC_002677.1 hypothetical protein 222601 908522 ML0158 Mycobacterium leprae TN hypothetical protein NP_301243.1 221657 D 272631 CDS NP_301244.1 15826981 908525 222650..223942 1 NC_002677.1 hypothetical protein 223942 908525 ML0159 Mycobacterium leprae TN hypothetical protein NP_301244.1 222650 D 272631 CDS NP_301245.1 15826982 908527 223972..224619 1 NC_002677.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 224619 purN 908527 purN Mycobacterium leprae TN phosphoribosylglycinamide formyltransferase NP_301245.1 223972 D 272631 CDS NP_301246.1 15826983 908529 224616..226199 1 NC_002677.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 226199 purH 908529 purH Mycobacterium leprae TN bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_301246.1 224616 D 272631 CDS NP_301247.1 15826984 908533 complement(227008..227286) 1 NC_002677.1 hypothetical protein 227286 908533 ML0162 Mycobacterium leprae TN hypothetical protein NP_301247.1 227008 R 272631 CDS NP_301248.1 15826985 908537 234932..235534 1 NC_002677.1 hypothetical protein 235534 908537 ML0169 Mycobacterium leprae TN hypothetical protein NP_301248.1 234932 D 272631 CDS NP_301249.1 15826986 908550 240237..240410 1 NC_002677.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 240410 rpmF 908550 rpmF Mycobacterium leprae TN 50S ribosomal protein L32 NP_301249.1 240237 D 272631 CDS NP_301250.1 15826987 908551 240531..241217 1 NC_002677.1 two-component response regulator 241217 908551 ML0174 Mycobacterium leprae TN two-component response regulator NP_301250.1 240531 D 272631 CDS NP_301251.1 15826988 908554 241217..242776 1 NC_002677.1 two-component system sensor kinase 242776 908554 ML0175 Mycobacterium leprae TN two-component system sensor kinase NP_301251.1 241217 D 272631 CDS NP_301252.1 15826989 908555 243054..244202 1 NC_002677.1 serine protease 244202 908555 ML0176 Mycobacterium leprae TN serine protease NP_301252.1 243054 D 272631 CDS NP_301253.1 15826990 908557 244225..244770 1 NC_002677.1 molybdenum cofactor biosynthesis protein 244770 moaB 908557 moaB Mycobacterium leprae TN molybdenum cofactor biosynthesis protein NP_301253.1 244225 D 272631 CDS NP_301254.1 15826991 908560 complement(244787..245251) 1 NC_002677.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 245251 mscL 908560 mscL Mycobacterium leprae TN large-conductance mechanosensitive channel NP_301254.1 244787 R 272631 CDS NP_301255.1 15826992 908562 complement(246049..246348) 1 NC_002677.1 hypothetical protein 246348 908562 ML0180 Mycobacterium leprae TN hypothetical protein NP_301255.1 246049 R 272631 CDS NP_301256.1 15826993 908563 complement(246423..247016) 1 NC_002677.1 hypothetical protein 247016 908563 ML0181 Mycobacterium leprae TN hypothetical protein NP_301256.1 246423 R 272631 CDS NP_301257.1 15826994 908564 247094..248014 1 NC_002677.1 UTP-glucose-1-phosphate uridylyltransferase 248014 galU 908564 galU Mycobacterium leprae TN UTP-glucose-1-phosphate uridylyltransferase NP_301257.1 247094 D 272631 CDS NP_301258.1 15826995 908566 248102..249376 1 NC_002677.1 molybdopterin biosynthesis protein 249376 moeA 908566 moeA Mycobacterium leprae TN molybdopterin biosynthesis protein NP_301258.1 248102 D 272631 CDS NP_301259.1 15826996 908570 249407..250051 1 NC_002677.1 acetyltransferase 250051 rimJ 908570 rimJ Mycobacterium leprae TN acetyltransferase NP_301259.1 249407 D 272631 CDS NP_301260.1 15826997 908571 250221..251249 1 NC_002677.1 hypothetical protein 251249 908571 ML0185 Mycobacterium leprae TN hypothetical protein NP_301260.1 250221 D 272631 CDS NP_301261.1 15826998 908577 252658..253719 1 NC_002677.1 hypothetical protein 253719 908577 ML0187 Mycobacterium leprae TN hypothetical protein NP_301261.1 252658 D 272631 CDS NP_301262.1 15826999 908579 254028..254291 1 NC_002677.1 hypothetical protein 254291 908579 ML0188 Mycobacterium leprae TN hypothetical protein NP_301262.1 254028 D 272631 CDS NP_301263.1 15827000 908584 complement(255125..255742) 1 NC_002677.1 hypothetical protein 255742 908584 ML0190 Mycobacterium leprae TN hypothetical protein NP_301263.1 255125 R 272631 CDS NP_301264.1 15827001 908586 complement(257035..258567) 1 NC_002677.1 hypothetical protein 258567 908586 ML0192 Mycobacterium leprae TN hypothetical protein NP_301264.1 257035 R 272631 CDS NP_301265.1 15827002 908587 258646..259491 1 NC_002677.1 hypothetical protein 259491 908587 ML0193 Mycobacterium leprae TN hypothetical protein NP_301265.1 258646 D 272631 CDS NP_301266.1 15827003 908596 264898..265101 1 NC_002677.1 cold shock protein 265101 cspA 908596 cspA Mycobacterium leprae TN cold shock protein NP_301266.1 264898 D 272631 CDS NP_301267.1 15827004 908598 265213..265815 1 NC_002677.1 Similar to M. tuberculosis Rv3647c, hypothetical protein, TR:O06361 (EMBL:AL123456) (192 aa); Fasta score E(): 0, 80.4% identity in 199 aa overlap. Previously sequenced as TR:O69549 (EMBL:AL023093) (200 aa); Fasta score E(): 0, 99.5% identity in 200 aa overlap.; hypothetical protein 265815 908598 ML0199 Mycobacterium leprae TN hypothetical protein NP_301267.1 265213 D 272631 CDS NP_301268.1 15827005 908599 266033..268876 1 NC_002677.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 268876 topA 908599 topA Mycobacterium leprae TN DNA topoisomerase I NP_301268.1 266033 D 272631 CDS NP_301269.1 15827006 908603 complement(268857..270449) 1 NC_002677.1 hypothetical protein 270449 908603 ML0201 Mycobacterium leprae TN hypothetical protein NP_301269.1 268857 R 272631 CDS NP_301270.1 15827007 908611 270605..271822 1 NC_002677.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 271822 908611 ML0202 Mycobacterium leprae TN DNA polymerase III subunit delta' NP_301270.1 270605 D 272631 CDS NP_301271.1 15827008 908612 complement(273290..274999) 1 NC_002677.1 hypothetical protein 274999 908612 ML0203 Mycobacterium leprae TN hypothetical protein NP_301271.1 273290 R 272631 CDS NP_301272.1 15827009 908608 275049..276008 1 NC_002677.1 sugar-nucleotide dehydratase 276008 rmlB2 908608 rmlB2 Mycobacterium leprae TN sugar-nucleotide dehydratase NP_301272.1 275049 D 272631 CDS NP_301273.1 15827010 909886 complement(276707..277777) 1 NC_002677.1 hypothetical protein 277777 909886 ML0205 Mycobacterium leprae TN hypothetical protein NP_301273.1 276707 R 272631 CDS NP_301274.1 15827011 908618 279051..279770 1 NC_002677.1 glycosyltransferase 279770 908618 ML0207 Mycobacterium leprae TN glycosyltransferase NP_301274.1 279051 D 272631 CDS NP_301275.1 15827012 908621 279784..280125 1 NC_002677.1 hypothetical protein 280125 908621 ML0208 Mycobacterium leprae TN hypothetical protein NP_301275.1 279784 D 272631 CDS NP_301276.1 15827013 908623 complement(281543..282031) 1 NC_002677.1 catalyzes the hydrolysis of pyrophosphate; inorganic pyrophosphatase 282031 ppa 908623 ppa Mycobacterium leprae TN inorganic pyrophosphatase NP_301276.1 281543 R 272631 CDS NP_301277.1 15827014 909586 282157..283542 1 NC_002677.1 carboxypeptidase 283542 909586 ML0211 Mycobacterium leprae TN carboxypeptidase NP_301277.1 282157 D 272631 CDS NP_301278.1 15827015 909579 284580..285551 1 NC_002677.1 hypothetical protein 285551 mesJ 909579 mesJ Mycobacterium leprae TN hypothetical protein NP_301278.1 284580 D 272631 CDS NP_301279.1 15827016 909576 285584..286225 1 NC_002677.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 286225 hpt 909576 hpt Mycobacterium leprae TN hypoxanthine-guanine phosphoribosyltransferase NP_301279.1 285584 D 272631 CDS NP_301280.1 15827017 908629 288678..288923 1 NC_002677.1 hypothetical protein 288923 908629 ML0217 Mycobacterium leprae TN hypothetical protein NP_301280.1 288678 D 272631 CDS NP_301281.1 15827018 908630 complement(289829..290215) 1 NC_002677.1 hypothetical protein 290215 908630 ML0218 Mycobacterium leprae TN hypothetical protein NP_301281.1 289829 R 272631 CDS NP_301282.1 15827019 908637 293693..296065 1 NC_002677.1 integral membrane peptidase 296065 ftsH 908637 ftsH Mycobacterium leprae TN integral membrane peptidase NP_301282.1 293693 D 272631 CDS NP_301283.1 15827020 909895 296082..296699 1 NC_002677.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 296699 folE 909895 folE Mycobacterium leprae TN GTP cyclohydrolase I NP_301283.1 296082 D 272631 CDS NP_301284.1 15827021 908646 296696..297550 1 NC_002677.1 dihydropteroate synthase 297550 folP 908646 folP Mycobacterium leprae TN dihydropteroate synthase NP_301284.1 296696 D 272631 CDS NP_301285.1 15827022 908411 297543..297941 1 NC_002677.1 dihydroneopterin aldolase 297941 folB 908411 folB Mycobacterium leprae TN dihydroneopterin aldolase NP_301285.1 297543 D 272631 CDS NP_301286.1 15827023 908689 297941..298516 1 NC_002677.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 298516 folK 908689 folK Mycobacterium leprae TN 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_301286.1 297941 D 272631 CDS NP_301287.1 15827024 908697 298516..298992 1 NC_002677.1 hypothetical protein 298992 908697 ML0227 Mycobacterium leprae TN hypothetical protein NP_301287.1 298516 D 272631 CDS NP_301288.1 15827025 908664 299138..300436 1 NC_002677.1 hypothetical protein 300436 908664 ML0228 Mycobacterium leprae TN hypothetical protein NP_301288.1 299138 D 272631 CDS NP_301289.1 15827026 908662 300537..301466 1 NC_002677.1 hypothetical protein 301466 908662 ML0229 Mycobacterium leprae TN hypothetical protein NP_301289.1 300537 D 272631 CDS NP_301290.1 15827027 908653 301463..302404 1 NC_002677.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 302404 panC 908653 panC Mycobacterium leprae TN pantoate--beta-alanine ligase NP_301290.1 301463 D 272631 CDS NP_301291.1 15827028 908678 302404..302832 1 NC_002677.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 302832 panD 908678 panD Mycobacterium leprae TN aspartate alpha-decarboxylase NP_301291.1 302404 D 272631 CDS NP_301292.1 15827029 908665 302835..303659 1 NC_002677.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 303659 908665 ML0232 Mycobacterium leprae TN pantothenate kinase NP_301292.1 302835 D 272631 CDS NP_301293.1 15827030 908650 303740..305263 1 NC_002677.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 305263 lysS 908650 lysS Mycobacterium leprae TN lysyl-tRNA synthetase NP_301293.1 303740 D 272631 CDS NP_301294.1 15827031 909223 305368..305706 1 NC_002677.1 lsr2 protein (15 kDa antigen) 305706 lsr2 909223 lsr2 Mycobacterium leprae TN lsr2 protein (15 kDa antigen) NP_301294.1 305368 D 272631 CDS NP_301295.1 15827032 908260 306003..308549 1 NC_002677.1 ATP-dependent Clp protease 308549 clpC 908260 clpC Mycobacterium leprae TN ATP-dependent Clp protease NP_301295.1 306003 D 272631 CDS NP_301296.1 15827033 908703 complement(309643..310899) 1 NC_002677.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I 310899 pabB 908703 pabB Mycobacterium leprae TN aminodeoxychorismate synthase component I NP_301296.1 309643 R 272631 CDS NP_301297.1 15827034 908704 complement(312208..313821) 1 NC_002677.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 313821 metG 908704 metG Mycobacterium leprae TN methionyl-tRNA synthetase NP_301297.1 312208 R 272631 CDS NP_301298.1 15827035 908709 313910..314698 1 NC_002677.1 hypothetical protein 314698 908709 ML0239 Mycobacterium leprae TN hypothetical protein NP_301298.1 313910 D 272631 CDS NP_301299.1 15827036 908712 314948..316075 1 NC_002677.1 hypothetical protein 316075 908712 ML0240 Mycobacterium leprae TN hypothetical protein NP_301299.1 314948 D 272631 CDS NP_301300.1 15827037 908714 316048..316968 1 NC_002677.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 316968 ksgA 908714 ksgA Mycobacterium leprae TN dimethyladenosine transferase NP_301300.1 316048 D 272631 CDS NP_301301.1 15827038 908715 317042..317977 1 NC_002677.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 317977 908715 ML0242 Mycobacterium leprae TN 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_301301.1 317042 D 272631 CDS NP_301302.1 15827039 908719 318220..319854 1 NC_002677.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 319854 908719 ML0243 Mycobacterium leprae TN long-chain-fatty-acid--CoA ligase NP_301302.1 318220 D 272631 CDS NP_301303.1 15827040 908725 complement(319965..320564) 1 NC_002677.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 320564 pth 908725 pth Mycobacterium leprae TN peptidyl-tRNA hydrolase NP_301303.1 319965 R 272631 CDS NP_301304.1 15827041 908726 complement(320577..321224) 1 NC_002677.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 321224 rplY 908726 rplY Mycobacterium leprae TN 50S ribosomal protein L25 NP_301304.1 320577 R 272631 CDS NP_301305.1 15827042 908727 complement(322399..323055) 1 NC_002677.1 lipoprotein 323055 lpqT 908727 lpqT Mycobacterium leprae TN lipoprotein NP_301305.1 322399 R 272631 CDS NP_301306.1 15827043 908728 complement(323092..323406) 1 NC_002677.1 arsenate reductase 323406 arsC 908728 arsC Mycobacterium leprae TN arsenate reductase NP_301306.1 323092 R 272631 CDS NP_301307.1 15827044 908729 complement(323462..324445) 1 NC_002677.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 324445 prsA 908729 prsA Mycobacterium leprae TN ribose-phosphate pyrophosphokinase NP_301307.1 323462 R 272631 CDS NP_301308.1 15827045 908736 complement(324556..326034) 1 NC_002677.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 326034 glmU 908736 glmU Mycobacterium leprae TN bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_301308.1 324556 R 272631 CDS NP_301309.1 15827046 908750 328067..331741 1 NC_002677.1 transcription-repair coupling factor 331741 mfd 908750 mfd Mycobacterium leprae TN transcription-repair coupling factor NP_301309.1 328067 D 272631 CDS NP_301310.1 15827047 908757 333751..335094 1 NC_002677.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 335094 eno 908757 eno Mycobacterium leprae TN phosphopyruvate hydratase NP_301310.1 333751 D 272631 CDS NP_301311.1 15827048 908762 335129..335812 1 NC_002677.1 hypothetical protein 335812 908762 ML0256 Mycobacterium leprae TN hypothetical protein NP_301311.1 335129 D 272631 CDS NP_301312.1 15827049 908763 335805..336308 1 NC_002677.1 hypothetical protein 336308 908763 ML0257 Mycobacterium leprae TN hypothetical protein NP_301312.1 335805 D 272631 CDS NP_301313.1 15827050 909924 336305..337258 1 NC_002677.1 hypothetical protein 337258 909924 ML0258 Mycobacterium leprae TN hypothetical protein NP_301313.1 336305 D 272631 CDS NP_301314.1 15827051 908772 345708..345920 1 NC_002677.1 hypothetical protein 345920 908772 ML0265 Mycobacterium leprae TN hypothetical protein NP_301314.1 345708 D 272631 CDS NP_301315.1 15827052 908785 complement(353007..354017) 1 NC_002677.1 F420-dependent glucose-6-phosphate dehydrogenase 354017 908785 ML0269 Mycobacterium leprae TN F420-dependent glucose-6-phosphate dehydrogenase NP_301315.1 353007 R 272631 CDS NP_301316.1 15827053 908790 354105..354860 1 NC_002677.1 hypothetical protein 354860 908790 ML0270 Mycobacterium leprae TN hypothetical protein NP_301316.1 354105 D 272631 CDS NP_301317.1 15827054 908793 complement(354849..355220) 1 NC_002677.1 hypothetical protein 355220 908793 ML0271 Mycobacterium leprae TN hypothetical protein NP_301317.1 354849 R 272631 CDS NP_301318.1 15827055 908802 complement(357557..358777) 1 NC_002677.1 O-succinylhomoserine sulfhydrylase 358777 metZ 908802 metZ Mycobacterium leprae TN O-succinylhomoserine sulfhydrylase NP_301318.1 357557 R 272631 CDS NP_301319.1 15827056 908803 complement(358834..359277) 1 NC_002677.1 hypothetical protein 359277 908803 ML0276 Mycobacterium leprae TN hypothetical protein NP_301319.1 358834 R 272631 CDS NP_301320.1 15827057 908814 complement(361297..361953) 1 NC_002677.1 hypothetical protein 361953 908814 ML0279 Mycobacterium leprae TN hypothetical protein NP_301320.1 361297 R 272631 CDS NP_301321.1 15827058 908815 complement(361950..363248) 1 NC_002677.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 363248 purA 908815 purA Mycobacterium leprae TN adenylosuccinate synthetase NP_301321.1 361950 R 272631 CDS NP_301322.1 15827059 908819 363432..364121 1 NC_002677.1 hypothetical protein 364121 908819 ML0281 Mycobacterium leprae TN hypothetical protein NP_301322.1 363432 D 272631 CDS NP_301323.1 15827060 909352 364916..365722 1 NC_002677.1 cation-efflux transporter component 365722 909352 ML0283 Mycobacterium leprae TN cation-efflux transporter component NP_301323.1 364916 D 272631 CDS NP_301324.1 15827061 908258 complement(365860..366273) 1 NC_002677.1 hypothetical protein 366273 908258 ML0284 Mycobacterium leprae TN hypothetical protein NP_301324.1 365860 R 272631 CDS NP_301325.1 15827062 908823 366385..367263 1 NC_002677.1 hypothetical protein 367263 908823 ML0285 Mycobacterium leprae TN hypothetical protein NP_301325.1 366385 D 272631 CDS NP_301326.1 15827063 908824 complement(367279..368316) 1 NC_002677.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 368316 fba 908824 fba Mycobacterium leprae TN fructose-bisphosphate aldolase NP_301326.1 367279 R 272631 CDS NP_301327.1 15827064 908826 368449..369117 1 NC_002677.1 hypothetical protein 369117 908826 ML0287 Mycobacterium leprae TN hypothetical protein NP_301327.1 368449 D 272631 CDS NP_301328.1 15827065 908832 complement(372034..372426) 1 NC_002677.1 hypothetical protein 372426 908832 ML0291 Mycobacterium leprae TN hypothetical protein NP_301328.1 372034 R 272631 CDS NP_301329.1 15827066 908838 complement(373605..373844) 1 NC_002677.1 hypothetical protein 373844 908838 ML0292 Mycobacterium leprae TN hypothetical protein NP_301329.1 373605 R 272631 CDS NP_301330.1 15827067 908839 complement(375453..375662) 1 NC_002677.1 hypothetical protein 375662 908839 ML0293 Mycobacterium leprae TN hypothetical protein NP_301330.1 375453 R 272631 CDS NP_301331.1 15827068 908846 377487..379130 1 NC_002677.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 379130 thiC 908846 thiC Mycobacterium leprae TN thiamine biosynthesis protein ThiC NP_301331.1 377487 D 272631 CDS NP_301332.1 15827069 908848 379127..379966 1 NC_002677.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 379966 thiD 908848 thiD Mycobacterium leprae TN phosphomethylpyrimidine kinase NP_301332.1 379127 D 272631 CDS NP_301333.1 15827070 908850 complement(380645..381430) 1 NC_002677.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 381430 thiG 908850 thiG Mycobacterium leprae TN thiazole synthase NP_301333.1 380645 R 272631 CDS NP_301334.1 15827071 908851 complement(381423..381647) 1 NC_002677.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 381647 908851 ML0298 Mycobacterium leprae TN sulfur carrier protein ThiS NP_301334.1 381423 R 272631 CDS NP_301335.1 15827072 908853 complement(381655..382677) 1 NC_002677.1 oxidoreductase 382677 908853 ML0299 Mycobacterium leprae TN oxidoreductase NP_301335.1 381655 R 272631 CDS NP_301336.1 15827073 908861 382835..383542 1 NC_002677.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 383542 thiE 908861 thiE Mycobacterium leprae TN thiamine-phosphate pyrophosphorylase NP_301336.1 382835 D 272631 CDS NP_301337.1 15827074 908869 385649..386629 1 NC_002677.1 glutamine-binding protein 386629 glnH 908869 glnH Mycobacterium leprae TN glutamine-binding protein NP_301337.1 385649 D 272631 CDS NP_301338.1 15827075 908881 386629..388932 1 NC_002677.1 serine-threonine protein kinase 388932 pknG 908881 pknG Mycobacterium leprae TN serine-threonine protein kinase NP_301338.1 386629 D 272631 CDS NP_301339.1 15827076 908883 394457..395161 1 NC_002677.1 hypothetical protein 395161 908883 ML0308 Mycobacterium leprae TN hypothetical protein NP_301339.1 394457 D 272631 CDS NP_301340.1 15827077 909217 complement(397046..397948) 1 NC_002677.1 CDP-diacylglycerol-serine o-phosphatidyltransferase 397948 pssA 909217 pssA Mycobacterium leprae TN CDP-diacylglycerol-serine o-phosphatidyltransferase NP_301340.1 397046 R 272631 CDS NP_301341.1 15827078 908894 complement(397945..398676) 1 NC_002677.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 398676 908894 ML0311 Mycobacterium leprae TN phosphatidylserine decarboxylase NP_301341.1 397945 R 272631 CDS NP_301342.1 15827079 908895 complement(400771..401778) 1 NC_002677.1 esterase 401778 908895 ML0314 Mycobacterium leprae TN esterase NP_301342.1 400771 R 272631 CDS NP_301343.1 15827080 908901 complement(403698..404612) 1 NC_002677.1 short chain dehydrogenase 404612 908901 ML0315 Mycobacterium leprae TN short chain dehydrogenase NP_301343.1 403698 R 272631 CDS NP_301344.1 15827081 908902 404707..405309 1 NC_002677.1 TetR/AcrR family transcriptional regulator 405309 908902 ML0316 Mycobacterium leprae TN TetR/AcrR family transcriptional regulator NP_301344.1 404707 D 272631 CDS NP_301345.1 15827082 908906 405518..407143 1 NC_002677.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 407143 groEL 908906 groEL Mycobacterium leprae TN molecular chaperone GroEL NP_301345.1 405518 D 272631 CDS NP_301346.1 15827083 909986 complement(409442..409993) 1 NC_002677.1 lipoprotein 409993 lpqE 909986 lpqE Mycobacterium leprae TN lipoprotein NP_301346.1 409442 R 272631 CDS NP_301347.1 15827084 908908 410354..410851 1 NC_002677.1 transcription factor 410851 908908 ML0320 Mycobacterium leprae TN transcription factor NP_301347.1 410354 D 272631 CDS NP_301348.1 15827085 908913 410870..411595 1 NC_002677.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 411595 ispD 908913 ispD Mycobacterium leprae TN 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_301348.1 410870 D 272631 CDS NP_301349.1 15827086 908920 411592..412068 1 NC_002677.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 412068 ispF 908920 ispF Mycobacterium leprae TN 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_301349.1 411592 D 272631 CDS NP_301350.1 15827087 908923 412123..413544 1 NC_002677.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 413544 cysS 908923 cysS Mycobacterium leprae TN cysteinyl-tRNA synthetase NP_301350.1 412123 D 272631 CDS NP_301351.1 15827088 908924 413627..414463 1 NC_002677.1 methyltransferase 414463 908924 ML0324 Mycobacterium leprae TN methyltransferase NP_301351.1 413627 D 272631 CDS NP_301352.1 15827089 908919 414865..415128 1 NC_002677.1 hypothetical protein 415128 908919 ML0325 Mycobacterium leprae TN hypothetical protein NP_301352.1 414865 D 272631 CDS NP_301353.1 15827090 908943 complement(423178..423936) 1 NC_002677.1 LamB/YcsF family protein 423936 908943 ML0333 Mycobacterium leprae TN LamB/YcsF family protein NP_301353.1 423178 R 272631 CDS NP_301354.1 15827091 908949 complement(424867..425727) 1 NC_002677.1 ABC-transporter transmembrane protein 425727 908949 ML0335 Mycobacterium leprae TN ABC-transporter transmembrane protein NP_301354.1 424867 R 272631 CDS NP_301355.1 15827092 908873 complement(425727..426554) 1 NC_002677.1 ABC-transporter ATP-binding protein 426554 908873 ML0336 Mycobacterium leprae TN ABC-transporter ATP-binding protein NP_301355.1 425727 R 272631 CDS NP_301356.1 15827093 908929 complement(426563..427471) 1 NC_002677.1 periplasmic solute-binding proteins 427471 908929 ML0337 Mycobacterium leprae TN periplasmic solute-binding proteins NP_301356.1 426563 R 272631 CDS NP_301357.1 15827094 908969 438262..439314 1 NC_002677.1 coenzyme F420-dependent oxidoreductase 439314 908969 ML0348 Mycobacterium leprae TN coenzyme F420-dependent oxidoreductase NP_301357.1 438262 D 272631 CDS NP_301358.1 15827095 908997 447414..448961 1 NC_002677.1 thiamine-pyrophosphate requiring enzyme; hypothetical protein 448961 ilvX 908997 ilvX Mycobacterium leprae TN hypothetical protein NP_301358.1 447414 D 272631 CDS NP_301359.1 15827096 909015 456418..456732 1 NC_002677.1 hypothetical protein 456732 909015 ML0363 Mycobacterium leprae TN hypothetical protein NP_301359.1 456418 D 272631 CDS NP_301360.1 15827097 909021 456984..457427 1 NC_002677.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 457427 rplM 909021 rplM Mycobacterium leprae TN 50S ribosomal protein L13 NP_301360.1 456984 D 272631 CDS NP_301361.1 15827098 909023 457424..457885 1 NC_002677.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 457885 rpsI 909023 rpsI Mycobacterium leprae TN 30S ribosomal protein S9 NP_301361.1 457424 D 272631 CDS NP_301362.1 15827099 909025 457992..459383 1 NC_002677.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 459383 glmM 909025 glmM Mycobacterium leprae TN phosphoglucosamine mutase NP_301362.1 457992 D 272631 CDS NP_301363.1 15827100 909042 complement(461185..461541) 1 NC_002677.1 hypothetical protein 461541 909042 ML0369 Mycobacterium leprae TN hypothetical protein NP_301363.1 461185 R 272631 CDS NP_301364.1 15827101 909043 complement(461945..462814) 1 NC_002677.1 hypothetical protein 462814 909043 ML0370 Mycobacterium leprae TN hypothetical protein NP_301364.1 461945 R 272631 CDS NP_301365.1 15827102 909050 462979..464856 1 NC_002677.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 464856 glmS 909050 glmS Mycobacterium leprae TN glucosamine--fructose-6-phosphate aminotransferase NP_301365.1 462979 D 272631 CDS NP_301366.1 15827103 909029 465202..466623 1 NC_002677.1 hypothetical protein 466623 909029 ML0373 Mycobacterium leprae TN hypothetical protein NP_301366.1 465202 D 272631 CDS NP_301367.1 15827104 909060 468132..469298 1 NC_002677.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 469298 alr 909060 alr Mycobacterium leprae TN alanine racemase NP_301367.1 468132 D 272631 CDS NP_301368.1 15827105 909058 469288..470289 1 NC_002677.1 hypothetical protein 470289 909058 ML0376 Mycobacterium leprae TN hypothetical protein NP_301368.1 469288 D 272631 CDS NP_301369.1 15827106 909051 470282..470767 1 NC_002677.1 Similar to M. tuberculosis Rv3422c, conserved hypothetical protein, SW:YY22_MYCTU (Q50706) (168 aa); Fasta score E(): 0, 77.4% identity in 146 aa overlap. Similar to many other bacterial hypothetical proteins. Previously sequenced as SW:YY22_MYCLE (Q49864) (161 aa); Fasta score E(): 0, 100.0% identity in 161 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).; hypothetical protein 470767 909051 ML0377 Mycobacterium leprae TN hypothetical protein NP_301369.1 470282 D 272631 CDS NP_301370.1 15827107 909063 470764..471843 1 NC_002677.1 acetyltransferase 471843 909063 ML0378 Mycobacterium leprae TN acetyltransferase NP_301370.1 470764 D 272631 CDS NP_301371.1 15827108 909071 471840..472895 1 NC_002677.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 472895 gcp 909071 gcp Mycobacterium leprae TN DNA-binding/iron metalloprotein/AP endonuclease NP_301371.1 471840 D 272631 CDS NP_301372.1 15827109 909076 473177..473479 1 NC_002677.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 473479 groES 909076 groES Mycobacterium leprae TN co-chaperonin GroES NP_301372.1 473177 D 272631 CDS NP_301373.1 15827110 909064 473558..475171 1 NC_002677.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL 475171 groEL 909064 groEL Mycobacterium leprae TN molecular chaperone GroEL NP_301373.1 473558 D 272631 CDS NP_301374.1 15827111 909062 complement(475771..476079) 1 NC_002677.1 transcriptional regulator 476079 whiB3 909062 whiB3 Mycobacterium leprae TN transcriptional regulator NP_301374.1 475771 R 272631 CDS NP_301375.1 15827112 909081 476440..477285 1 NC_002677.1 hypothetical protein 477285 909081 ML0383 Mycobacterium leprae TN hypothetical protein NP_301375.1 476440 D 272631 CDS NP_301376.1 15827113 909089 complement(480093..480506) 1 NC_002677.1 hypothetical protein 480506 909089 ML0386 Mycobacterium leprae TN hypothetical protein NP_301376.1 480093 R 272631 CDS NP_301377.1 15827114 909092 480661..482250 1 NC_002677.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 482250 guaB2 909092 guaB2 Mycobacterium leprae TN inosine 5'-monophosphate dehydrogenase NP_301377.1 480661 D 272631 CDS NP_301378.1 15827115 909090 482274..483386 1 NC_002677.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 483386 guaB3 909090 guaB3 Mycobacterium leprae TN inosine 5-monophosphate dehydrogenase NP_301378.1 482274 D 272631 CDS NP_301379.1 15827116 909085 483451..485160 1 NC_002677.1 cholesterol oxidase 485160 choD 909085 choD Mycobacterium leprae TN cholesterol oxidase NP_301379.1 483451 D 272631 CDS NP_301380.1 15827117 909082 complement(486263..488641) 1 NC_002677.1 sugar phosphorylase 488641 909082 ML0392 Mycobacterium leprae TN sugar phosphorylase NP_301380.1 486263 R 272631 CDS NP_301381.1 15827118 909103 complement(488655..489440) 1 NC_002677.1 hydrolase 489440 909103 ML0393 Mycobacterium leprae TN hydrolase NP_301381.1 488655 R 272631 CDS NP_301382.1 15827119 909105 complement(489915..490427) 1 NC_002677.1 hypothetical protein 490427 909105 ML0394 Mycobacterium leprae TN hypothetical protein NP_301382.1 489915 R 272631 CDS NP_301383.1 15827120 909317 491043..492632 1 NC_002677.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 492632 guaA 909317 guaA Mycobacterium leprae TN GMP synthase NP_301383.1 491043 D 272631 CDS NP_301384.1 15827121 909120 complement(492714..493823) 1 NC_002677.1 hypothetical protein 493823 909120 ML0396 Mycobacterium leprae TN hypothetical protein NP_301384.1 492714 R 272631 CDS NP_301385.1 15827122 909124 complement(493939..495747) 1 NC_002677.1 transporter protein 495747 909124 ML0397 Mycobacterium leprae TN transporter protein NP_301385.1 493939 R 272631 CDS NP_301386.1 15827123 909148 complement(496060..497097) 1 NC_002677.1 D-ribose-binding protein 497097 909148 ML0398 Mycobacterium leprae TN D-ribose-binding protein NP_301386.1 496060 R 272631 CDS NP_301387.1 15827124 909138 503217..504401 1 NC_002677.1 hypothetical protein 504401 909138 ML0405 Mycobacterium leprae TN hypothetical protein NP_301387.1 503217 D 272631 CDS NP_301388.1 15827125 909142 504459..504779 1 NC_002677.1 hypothetical protein 504779 909142 ML0406 Mycobacterium leprae TN hypothetical protein NP_301388.1 504459 D 272631 CDS NP_301389.1 15827126 909144 504793..505443 1 NC_002677.1 hypothetical protein 505443 909144 ML0407 Mycobacterium leprae TN hypothetical protein NP_301389.1 504793 D 272631 CDS NP_301390.1 15827127 909139 508327..508629 1 NC_002677.1 PE-family protein 508629 909139 ML0410 Mycobacterium leprae TN PE-family protein NP_301390.1 508327 D 272631 CDS NP_301391.1 15827128 909149 508755..509981 1 NC_002677.1 serine-rich protein 509981 909149 ML0411 Mycobacterium leprae TN serine-rich protein NP_301391.1 508755 D 272631 CDS NP_301392.1 15827129 909153 complement(511984..513273) 1 NC_002677.1 trehalose-6-phosphate phosphatase 513273 otsB2 909153 otsB2 Mycobacterium leprae TN trehalose-6-phosphate phosphatase NP_301392.1 511984 R 272631 CDS NP_301393.1 15827130 909158 517644..518276 1 NC_002677.1 oxidoreductase 518276 909158 ML0418 Mycobacterium leprae TN oxidoreductase NP_301393.1 517644 D 272631 CDS NP_301394.1 15827131 909160 complement(518414..518890) 1 NC_002677.1 tRNA/rRNA methyltransferase 518890 909160 ML0419 Mycobacterium leprae TN tRNA/rRNA methyltransferase NP_301394.1 518414 R 272631 CDS NP_301395.1 15827132 909166 complement(523803..524288) 1 NC_002677.1 antioxidant protein 524288 bcp 909166 bcp Mycobacterium leprae TN antioxidant protein NP_301395.1 523803 R 272631 CDS NP_301396.1 15827133 909167 524416..524643 1 NC_002677.1 hypothetical protein 524643 909167 ML0425 Mycobacterium leprae TN hypothetical protein NP_301396.1 524416 D 272631 CDS NP_301397.1 15827134 909169 524929..526143 1 NC_002677.1 hypothetical protein 526143 lppS 909169 lppS Mycobacterium leprae TN hypothetical protein NP_301397.1 524929 D 272631 CDS NP_301398.1 15827135 909171 complement(526294..526941) 1 NC_002677.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 526941 909171 ML0427 Mycobacterium leprae TN oligoribonuclease NP_301398.1 526294 R 272631 CDS NP_301399.1 15827136 909173 complement(528621..529427) 1 NC_002677.1 oxidoreductase 529427 909173 ML0429 Mycobacterium leprae TN oxidoreductase NP_301399.1 528621 R 272631 CDS NP_301400.1 15827137 909156 529520..530884 1 NC_002677.1 hypothetical protein 530884 909156 ML0430 Mycobacterium leprae TN hypothetical protein NP_301400.1 529520 D 272631 CDS NP_301401.1 15827138 909174 complement(530916..531695) 1 NC_002677.1 hypothetical protein 531695 909174 ML0431 Mycobacterium leprae TN hypothetical protein NP_301401.1 530916 R 272631 CDS NP_301402.1 15827139 909194 547312..547788 1 NC_002677.1 hypothetical protein 547788 909194 ML0447 Mycobacterium leprae TN hypothetical protein NP_301402.1 547312 D 272631 CDS NP_301403.1 15827140 909195 547992..548264 1 NC_002677.1 hypothetical protein 548264 909195 ML0448 Mycobacterium leprae TN hypothetical protein NP_301403.1 547992 D 272631 CDS NP_301404.1 15827141 909197 complement(550193..551116) 1 NC_002677.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 551116 909197 ML0450 Mycobacterium leprae TN pyridoxal biosynthesis lyase PdxS NP_301404.1 550193 R 272631 CDS NP_301405.1 15827142 909198 complement(551191..552240) 1 NC_002677.1 hypothetical protein 552240 909198 ML0451 Mycobacterium leprae TN hypothetical protein NP_301405.1 551191 R 272631 CDS NP_301406.1 15827143 909199 complement(552240..553364) 1 NC_002677.1 glycosyltransferase 553364 909199 ML0452 Mycobacterium leprae TN glycosyltransferase NP_301406.1 552240 R 272631 CDS NP_301407.1 15827144 909200 complement(553374..554336) 1 NC_002677.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 554336 909200 ML0453 Mycobacterium leprae TN lipid A biosynthesis lauroyl acyltransferase NP_301407.1 553374 R 272631 CDS NP_301408.1 15827145 909202 complement(554333..555052) 1 NC_002677.1 phosphatidyltransferase 555052 pgsA 909202 pgsA Mycobacterium leprae TN phosphatidyltransferase NP_301408.1 554333 R 272631 CDS NP_301409.1 15827146 909203 complement(555049..555669) 1 NC_002677.1 hypothetical protein 555669 909203 ML0455 Mycobacterium leprae TN hypothetical protein NP_301409.1 555049 R 272631 CDS NP_301410.1 15827147 909205 complement(555662..557770) 1 NC_002677.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 557770 thrS 909205 thrS Mycobacterium leprae TN threonyl-tRNA synthetase NP_301410.1 555662 R 272631 CDS NP_301411.1 15827148 909365 complement(558363..559268) 1 NC_002677.1 oxidoreductase 559268 909365 ML0458 Mycobacterium leprae TN oxidoreductase NP_301411.1 558363 R 272631 CDS NP_301412.1 15827149 909188 561808..562095 1 NC_002677.1 hypothetical protein 562095 909188 ML0464 Mycobacterium leprae TN hypothetical protein NP_301412.1 561808 D 272631 CDS NP_301413.1 15827150 909212 563632..564537 1 NC_002677.1 hypothetical protein 564537 909212 ML0466 Mycobacterium leprae TN hypothetical protein NP_301413.1 563632 D 272631 CDS NP_301414.1 15827151 909213 564583..565227 1 NC_002677.1 hypothetical protein 565227 dedA 909213 dedA Mycobacterium leprae TN hypothetical protein NP_301414.1 564583 D 272631 CDS NP_301415.1 15827152 909214 complement(566057..566839) 1 NC_002677.1 hypothetical protein 566839 909214 ML0468 Mycobacterium leprae TN hypothetical protein NP_301415.1 566057 R 272631 CDS NP_301416.1 15827153 909216 complement(571603..571893) 1 NC_002677.1 hypothetical protein 571893 909216 ML0470 Mycobacterium leprae TN hypothetical protein NP_301416.1 571603 R 272631 CDS NP_301417.1 15827154 909219 574032..574274 1 NC_002677.1 hypothetical protein 574274 909219 ML0472 Mycobacterium leprae TN hypothetical protein NP_301417.1 574032 D 272631 CDS NP_301418.1 15827155 909220 574538..574810 1 NC_002677.1 hypothetical protein 574810 909220 ML0473 Mycobacterium leprae TN hypothetical protein NP_301418.1 574538 D 272631 CDS NP_301419.2 229270460 909221 575544..576140 1 NC_002677.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 576140 909221 ML0474 Mycobacterium leprae TN glutamine amidotransferase subunit PdxT NP_301419.2 575544 D 272631 CDS NP_301420.1 15827157 909222 576361..577116 1 NC_002677.1 hypothetical protein 577116 909222 ML0475 Mycobacterium leprae TN hypothetical protein NP_301420.1 576361 D 272631 CDS NP_301421.1 15827158 909230 581224..581790 1 NC_002677.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 581790 ruvC 909230 ruvC Mycobacterium leprae TN Holliday junction resolvase NP_301421.1 581224 D 272631 CDS NP_301422.1 15827159 909231 581787..582398 1 NC_002677.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 582398 ruvA 909231 ruvA Mycobacterium leprae TN Holliday junction DNA helicase RuvA NP_301422.1 581787 D 272631 CDS NP_301423.1 15827160 909232 582395..583444 1 NC_002677.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 583444 ruvB 909232 ruvB Mycobacterium leprae TN Holliday junction DNA helicase RuvB NP_301423.1 582395 D 272631 CDS NP_301424.1 15827161 909234 complement(584381..587947) 1 NC_002677.1 acyl-CoA synthetase 587947 fadD9 909234 fadD9 Mycobacterium leprae TN acyl-CoA synthetase NP_301424.1 584381 R 272631 CDS NP_301425.1 15827162 909237 complement(588043..589383) 1 NC_002677.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 589383 gabT 909237 gabT Mycobacterium leprae TN 4-aminobutyrate aminotransferase NP_301425.1 588043 R 272631 CDS NP_301426.1 15827163 909239 589652..589996 1 NC_002677.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 589996 yajC 909239 yajC Mycobacterium leprae TN preprotein translocase subunit YajC NP_301426.1 589652 D 272631 CDS NP_301427.2 161723271 909240 590114..591829 1 NC_002677.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 591829 secD 909240 secD Mycobacterium leprae TN preprotein translocase subunit SecD NP_301427.2 590114 D 272631 CDS NP_301428.1 15827165 909241 591834..593249 1 NC_002677.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 593249 secF 909241 secF Mycobacterium leprae TN preprotein translocase subunit SecF NP_301428.1 591834 D 272631 CDS NP_301429.1 15827166 909242 593294..594961 1 NC_002677.1 lipoprotein 594961 909242 ML0489 Mycobacterium leprae TN lipoprotein NP_301429.1 593294 D 272631 CDS NP_301430.1 15827167 909244 595607..597970 1 NC_002677.1 GTP pyrophosphokinase 597970 relA 909244 relA Mycobacterium leprae TN GTP pyrophosphokinase NP_301430.1 595607 D 272631 CDS NP_301431.1 15827168 909245 complement(598029..598916) 1 NC_002677.1 peptidyl-prolyl cis-trans isomerase 598916 ppiB 909245 ppiB Mycobacterium leprae TN peptidyl-prolyl cis-trans isomerase NP_301431.1 598029 R 272631 CDS NP_301432.1 15827169 909236 599080..599736 1 NC_002677.1 hydrolase 599736 909236 ML0493 Mycobacterium leprae TN hydrolase NP_301432.1 599080 D 272631 CDS NP_301433.1 15827170 909246 599740..601023 1 NC_002677.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 601023 hisS 909246 hisS Mycobacterium leprae TN histidyl-tRNA synthetase NP_301433.1 599740 D 272631 CDS NP_301434.1 15827171 909256 606839..608608 1 NC_002677.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 608608 aspS 909256 aspS Mycobacterium leprae TN aspartyl-tRNA synthetase NP_301434.1 606839 D 272631 CDS NP_301435.1 15827172 909264 617501..618442 1 NC_002677.1 hypothetical protein 618442 909264 ML0508 Mycobacterium leprae TN hypothetical protein NP_301435.1 617501 D 272631 CDS NP_301436.1 15827173 909266 619666..621087 1 NC_002677.1 recombination factor protein RarA 621087 909266 ML0510 Mycobacterium leprae TN recombination factor protein RarA NP_301436.1 619666 D 272631 CDS NP_301437.1 15827174 909268 622159..624885 1 NC_002677.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 624885 alaS 909268 alaS Mycobacterium leprae TN alanyl-tRNA synthetase NP_301437.1 622159 D 272631 CDS NP_301438.1 15827175 909269 624886..625440 1 NC_002677.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 625440 909269 ML0513 Mycobacterium leprae TN Holliday junction resolvase-like protein NP_301438.1 624886 D 272631 CDS NP_301439.1 15827176 909271 625433..626698 1 NC_002677.1 hypothetical protein 626698 909271 ML0514 Mycobacterium leprae TN hypothetical protein NP_301439.1 625433 D 272631 CDS NP_301440.1 15827177 909272 626676..627512 1 NC_002677.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 627512 aroE 909272 aroE Mycobacterium leprae TN shikimate 5-dehydrogenase NP_301440.1 626676 D 272631 CDS NP_301441.1 15827178 909273 627741..628964 1 NC_002677.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 628964 aroF 909273 aroF Mycobacterium leprae TN chorismate synthase NP_301441.1 627741 D 272631 CDS NP_301442.1 15827179 909274 628972..629571 1 NC_002677.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 629571 aroK 909274 aroK Mycobacterium leprae TN shikimate kinase NP_301442.1 628972 D 272631 CDS NP_301443.1 15827180 909275 629568..630653 1 NC_002677.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 630653 aroB 909275 aroB Mycobacterium leprae TN 3-dehydroquinate synthase NP_301443.1 629568 D 272631 CDS NP_301444.1 15827181 909276 630653..631090 1 NC_002677.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 631090 aroD 909276 aroD Mycobacterium leprae TN 3-dehydroquinate dehydratase NP_301444.1 630653 D 272631 CDS NP_301445.1 15827182 909277 complement(631179..631787) 1 NC_002677.1 hypothetical protein 631787 909277 ML0520 Mycobacterium leprae TN hypothetical protein NP_301445.1 631179 R 272631 CDS NP_301446.1 15827183 909278 631821..632951 1 NC_002677.1 peptidase 632951 pepQ 909278 pepQ Mycobacterium leprae TN peptidase NP_301446.1 631821 D 272631 CDS NP_301447.1 15827184 909281 632967..633530 1 NC_002677.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 633530 efp 909281 efp Mycobacterium leprae TN elongation factor P NP_301447.1 632967 D 272631 CDS NP_301448.1 15827185 909283 633533..634105 1 NC_002677.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 634105 nusB 909283 nusB Mycobacterium leprae TN transcription antitermination protein NusB NP_301448.1 633533 D 272631 CDS NP_301449.1 15827186 909285 634643..637495 1 NC_002677.1 amino acid decarboxylase 637495 adi 909285 adi Mycobacterium leprae TN amino acid decarboxylase NP_301449.1 634643 D 272631 CDS NP_301450.1 15827187 909288 637492..637668 1 NC_002677.1 hypothetical protein 637668 909288 ML0525 Mycobacterium leprae TN hypothetical protein NP_301450.1 637492 D 272631 CDS NP_301451.1 15827188 909290 complement(639678..639932) 1 NC_002677.1 hypothetical protein 639932 909290 ML0527 Mycobacterium leprae TN hypothetical protein NP_301451.1 639678 R 272631 CDS NP_301452.1 15827189 908253 645581..646546 1 NC_002677.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 646546 pyrB 908253 pyrB Mycobacterium leprae TN aspartate carbamoyltransferase NP_301452.1 645581 D 272631 CDS NP_301453.1 15827190 909295 646543..647835 1 NC_002677.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 647835 pyrC 909295 pyrC Mycobacterium leprae TN dihydroorotase NP_301453.1 646543 D 272631 CDS NP_301454.1 15827191 909297 648422..649549 1 NC_002677.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 649549 carA 909297 carA Mycobacterium leprae TN carbamoyl phosphate synthase small subunit NP_301454.1 648422 D 272631 CDS NP_301455.2 161723270 909300 649632..652997 1 NC_002677.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 652997 carB 909300 carB Mycobacterium leprae TN carbamoyl phosphate synthase large subunit NP_301455.2 649632 D 272631 CDS NP_301456.1 15827193 909117 652994..653842 1 NC_002677.1 OMP decarboxylase; OMPDCase; OMPdecase; type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 653842 pyrF 909117 pyrF Mycobacterium leprae TN orotidine 5'-phosphate decarboxylase NP_301456.1 652994 D 272631 CDS NP_301457.1 15827194 909302 654129..654437 1 NC_002677.1 PE-family protein 654437 PE 909302 PE Mycobacterium leprae TN PE-family protein NP_301457.1 654129 D 272631 CDS NP_301458.1 15827195 909303 654434..656050 1 NC_002677.1 PPE family protein 656050 PPE 909303 PPE Mycobacterium leprae TN PPE family protein NP_301458.1 654434 D 272631 CDS NP_301459.1 15827196 909305 656895..657212 1 NC_002677.1 integration host factor 657212 mihF 909305 mihF Mycobacterium leprae TN integration host factor NP_301459.1 656895 D 272631 CDS NP_301460.1 15827197 909307 657266..657898 1 NC_002677.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 657898 gmk 909307 gmk Mycobacterium leprae TN guanylate kinase NP_301460.1 657266 D 272631 CDS NP_301461.1 15827198 909310 657980..658312 1 NC_002677.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 658312 909310 ML0542 Mycobacterium leprae TN DNA-directed RNA polymerase subunit omega NP_301461.1 657980 D 272631 CDS NP_301462.1 15827199 909311 658333..659592 1 NC_002677.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 659592 dfp 909311 dfp Mycobacterium leprae TN bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_301462.1 658333 D 272631 CDS NP_301463.1 15827200 909312 659721..660932 1 NC_002677.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 660932 metK 909312 metK Mycobacterium leprae TN S-adenosylmethionine synthetase NP_301463.1 659721 D 272631 CDS NP_301464.1 15827201 909319 664260..666215 1 NC_002677.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 666215 priA 909319 priA Mycobacterium leprae TN primosome assembly protein PriA NP_301464.1 664260 D 272631 CDS NP_301465.1 15827202 909322 667331..667816 1 NC_002677.1 MarR family transcriptional regulator 667816 909322 ML0550 Mycobacterium leprae TN MarR family transcriptional regulator NP_301465.1 667331 D 272631 CDS NP_301466.1 15827203 909323 complement(667998..668822) 1 NC_002677.1 methyltransferase 668822 909323 ML0551 Mycobacterium leprae TN methyltransferase NP_301466.1 667998 R 272631 CDS NP_301467.1 15827204 909326 669003..669959 1 NC_002677.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 669959 fmt 909326 fmt Mycobacterium leprae TN methionyl-tRNA formyltransferase NP_301467.1 669003 D 272631 CDS NP_301468.1 15827205 909330 671416..672090 1 NC_002677.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 672090 rpe 909330 rpe Mycobacterium leprae TN ribulose-phosphate 3-epimerase NP_301468.1 671416 D 272631 CDS NP_301469.1 15827206 909332 672087..673106 1 NC_002677.1 bifunctional riboflavin-specific deaminase/reductase 673106 ribG 909332 ribG Mycobacterium leprae TN bifunctional riboflavin-specific deaminase/reductase NP_301469.1 672087 D 272631 CDS NP_301470.1 15827207 909333 complement(673150..674679) 1 NC_002677.1 integral membrane drug transport protein 674679 909333 ML0556 Mycobacterium leprae TN integral membrane drug transport protein NP_301470.1 673150 R 272631 CDS NP_301471.1 15827208 909335 complement(674679..675395) 1 NC_002677.1 lipoprotein 675395 lprG 909335 lprG Mycobacterium leprae TN lipoprotein NP_301471.1 674679 R 272631 CDS NP_301472.1 15827209 909336 675552..676175 1 NC_002677.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 676175 ribC 909336 ribC Mycobacterium leprae TN riboflavin synthase subunit alpha NP_301472.1 675552 D 272631 CDS NP_301473.1 15827210 909338 676302..677609 1 NC_002677.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 677609 ribA 909338 ribA Mycobacterium leprae TN bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein NP_301473.1 676302 D 272631 CDS NP_301474.1 15827211 909339 677606..678088 1 NC_002677.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 678088 ribH 909339 ribH Mycobacterium leprae TN 6,7-dimethyl-8-ribityllumazine synthase NP_301474.1 677606 D 272631 CDS NP_301475.1 15827212 909342 678085..678555 1 NC_002677.1 hypothetical protein 678555 909342 ML0561 Mycobacterium leprae TN hypothetical protein NP_301475.1 678085 D 272631 CDS NP_301476.1 15827213 909343 678870..680813 1 NC_002677.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 680813 uvrC 909343 uvrC Mycobacterium leprae TN excinuclease ABC subunit C NP_301476.1 678870 D 272631 CDS NP_301477.1 15827214 909345 680810..681706 1 NC_002677.1 hypothetical protein 681706 909345 ML0563 Mycobacterium leprae TN hypothetical protein NP_301477.1 680810 D 272631 CDS NP_301478.1 15827215 909346 681703..682782 1 NC_002677.1 hypothetical protein 682782 909346 ML0564 Mycobacterium leprae TN hypothetical protein NP_301478.1 681703 D 272631 CDS NP_301479.1 15827216 909347 682779..683756 1 NC_002677.1 transcriptional regulator 683756 909347 ML0565 Mycobacterium leprae TN transcriptional regulator NP_301479.1 682779 D 272631 CDS NP_301480.1 15827217 909350 686813..687406 1 NC_002677.1 hypothetical protein 687406 909350 ML0568 Mycobacterium leprae TN hypothetical protein NP_301480.1 686813 D 272631 CDS NP_301481.1 15827218 908975 complement(693611..694426) 1 NC_002677.1 hypothetical protein 694426 908975 ML0569 Mycobacterium leprae TN hypothetical protein NP_301481.1 693611 R 272631 CDS NP_301482.1 15827219 909341 694889..695908 1 NC_002677.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 695908 gap 909341 gap Mycobacterium leprae TN glyceraldehyde-3-phosphate dehydrogenase NP_301482.1 694889 D 272631 CDS NP_301483.1 15827220 909304 695911..697161 1 NC_002677.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 697161 pgk 909304 pgk Mycobacterium leprae TN phosphoglycerate kinase NP_301483.1 695911 D 272631 CDS NP_301484.1 15827221 909354 697158..697943 1 NC_002677.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 697943 tpiA 909354 tpiA Mycobacterium leprae TN triosephosphate isomerase NP_301484.1 697158 D 272631 CDS NP_301485.1 15827222 909355 697927..698202 1 NC_002677.1 hypothetical protein 698202 909355 ML0573 Mycobacterium leprae TN hypothetical protein NP_301485.1 697927 D 272631 CDS NP_301486.1 15827223 909356 698199..698516 1 NC_002677.1 hypothetical protein 698516 909356 ML0574 Mycobacterium leprae TN hypothetical protein NP_301486.1 698199 D 272631 CDS NP_301487.1 15827224 909357 698674..698892 1 NC_002677.1 hypothetical protein 698892 909357 ML0575 Mycobacterium leprae TN hypothetical protein NP_301487.1 698674 D 272631 CDS NP_301488.1 15827225 909358 699708..699938 1 NC_002677.1 hypothetical protein 699938 909358 ML0576 Mycobacterium leprae TN hypothetical protein NP_301488.1 699708 D 272631 CDS NP_301489.1 15827226 909359 699950..700183 1 NC_002677.1 preprotein translocase subunit SecG 700183 secG 909359 secG Mycobacterium leprae TN preprotein translocase subunit SecG NP_301489.1 699950 D 272631 CDS NP_301490.1 15827227 909360 700214..703018 1 NC_002677.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 703018 ppc 909360 ppc Mycobacterium leprae TN phosphoenolpyruvate carboxylase NP_301490.1 700214 D 272631 CDS NP_301491.1 15827228 910133 complement(703242..703985) 1 NC_002677.1 catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone; 6-phosphogluconolactonase 703985 pgl 910133 pgl Mycobacterium leprae TN 6-phosphogluconolactonase NP_301491.1 703242 R 272631 CDS NP_301492.1 15827229 910130 complement(704001..704798) 1 NC_002677.1 hypothetical protein 704798 910130 ML0580 Mycobacterium leprae TN hypothetical protein NP_301492.1 704001 R 272631 CDS NP_301493.1 15827230 910135 complement(706461..707588) 1 NC_002677.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 707588 tal 910135 tal Mycobacterium leprae TN transaldolase NP_301493.1 706461 R 272631 CDS NP_301494.1 15827231 910090 complement(707605..709704) 1 NC_002677.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 709704 tkt 910090 tkt Mycobacterium leprae TN transketolase NP_301494.1 707605 R 272631 CDS NP_301495.1 15827232 908800 709904..710869 1 NC_002677.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 710869 ctaB 908800 ctaB Mycobacterium leprae TN protoheme IX farnesyltransferase NP_301495.1 709904 D 272631 CDS NP_301496.1 15827233 908788 complement(712668..713603) 1 NC_002677.1 hypothetical protein 713603 908788 ML0587 Mycobacterium leprae TN hypothetical protein NP_301496.1 712668 R 272631 CDS NP_301497.1 15827234 909363 713858..714100 1 NC_002677.1 hypothetical protein 714100 909363 ML0588 Mycobacterium leprae TN hypothetical protein NP_301497.1 713858 D 272631 CDS NP_301498.1 15827235 909364 complement(714234..715031) 1 NC_002677.1 hypothetical protein 715031 909364 ML0589 Mycobacterium leprae TN hypothetical protein NP_301498.1 714234 R 272631 CDS NP_301499.1 15827236 909361 complement(715031..715978) 1 NC_002677.1 ABC transporter ATP-binding protein 715978 909361 ML0590 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301499.1 715031 R 272631 CDS NP_301500.1 15827237 909367 complement(715975..717756) 1 NC_002677.1 hypothetical protein 717756 909367 ML0591 Mycobacterium leprae TN hypothetical protein NP_301500.1 715975 R 272631 CDS NP_301501.1 15827238 909368 717872..718636 1 NC_002677.1 DNA-binding protein 718636 909368 ML0592 Mycobacterium leprae TN DNA-binding protein NP_301501.1 717872 D 272631 CDS NP_301502.1 15827239 909370 718688..721297 1 NC_002677.1 hypothetical protein 721297 909370 ML0593 Mycobacterium leprae TN hypothetical protein NP_301502.1 718688 D 272631 CDS NP_301503.1 15827240 909372 721294..722472 1 NC_002677.1 hypothetical protein 722472 909372 ML0594 Mycobacterium leprae TN hypothetical protein NP_301503.1 721294 D 272631 CDS NP_301504.1 15827241 909374 722469..723251 1 NC_002677.1 ABC transporter ATP-binding protein 723251 909374 ML0595 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301504.1 722469 D 272631 CDS NP_301505.1 15827242 909377 723254..724510 1 NC_002677.1 aminotransferase 724510 909377 ML0596 Mycobacterium leprae TN aminotransferase NP_301505.1 723254 D 272631 CDS NP_301506.1 15827243 909378 724507..725004 1 NC_002677.1 hypothetical protein 725004 909378 ML0597 Mycobacterium leprae TN hypothetical protein NP_301506.1 724507 D 272631 CDS NP_301507.1 15827244 909379 724979..725326 1 NC_002677.1 hypothetical protein 725326 909379 ML0598 Mycobacterium leprae TN hypothetical protein NP_301507.1 724979 D 272631 CDS NP_301508.1 15827245 909387 735002..736117 1 NC_002677.1 hypothetical protein 736117 909387 ML0603 Mycobacterium leprae TN hypothetical protein NP_301508.1 735002 D 272631 CDS NP_301509.1 15827246 909389 complement(736154..736414) 1 NC_002677.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 736414 rpsT 909389 rpsT Mycobacterium leprae TN 30S ribosomal protein S20 NP_301509.1 736154 R 272631 CDS NP_301510.1 15827247 909390 736549..738234 1 NC_002677.1 hypothetical protein 738234 909390 ML0605 Mycobacterium leprae TN hypothetical protein NP_301510.1 736549 D 272631 CDS NP_301511.1 15827248 909392 738234..739211 1 NC_002677.1 hypothetical protein 739211 909392 ML0606 Mycobacterium leprae TN hypothetical protein NP_301511.1 738234 D 272631 CDS NP_301512.1 15827249 909393 739211..740050 1 NC_002677.1 hypothetical protein 740050 909393 ML0607 Mycobacterium leprae TN hypothetical protein NP_301512.1 739211 D 272631 CDS NP_301513.1 15827250 910558 742716..744656 1 NC_002677.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 744656 lepA 910558 lepA Mycobacterium leprae TN GTP-binding protein LepA NP_301513.1 742716 D 272631 CDS NP_301514.1 15827251 909397 747777..748064 1 NC_002677.1 hypothetical protein 748064 909397 ML0614 Mycobacterium leprae TN hypothetical protein NP_301514.1 747777 D 272631 CDS NP_301515.1 15827252 909396 748382..749428 1 NC_002677.1 sulfate-binding protein 749428 subI 909396 subI Mycobacterium leprae TN sulfate-binding protein NP_301515.1 748382 D 272631 CDS NP_301516.1 15827253 910360 753532..754035 1 NC_002677.1 hypothetical protein 754035 mtb12 910360 mtb12 Mycobacterium leprae TN hypothetical protein NP_301516.1 753532 D 272631 CDS NP_301517.1 15827254 909400 756770..757801 1 NC_002677.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 757801 hrcA 909400 hrcA Mycobacterium leprae TN heat-inducible transcription repressor NP_301517.1 756770 D 272631 CDS NP_301518.1 15827255 909409 757873..759009 1 NC_002677.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 759009 dnaJ2 909409 dnaJ2 Mycobacterium leprae TN molecular chaperone DnaJ NP_301518.1 757873 D 272631 CDS NP_301519.1 15827256 909410 759041..759814 1 NC_002677.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 759814 909410 ML0626 Mycobacterium leprae TN 16S ribosomal RNA methyltransferase RsmE NP_301519.1 759041 D 272631 CDS NP_301520.1 15827257 909408 760114..761163 1 NC_002677.1 phoH-family protein 761163 phoH 909408 phoH Mycobacterium leprae TN phoH-family protein NP_301520.1 760114 D 272631 CDS NP_301521.1 15827258 909407 761194..761730 1 NC_002677.1 metalloprotease 761730 909407 ML0628 Mycobacterium leprae TN metalloprotease NP_301521.1 761194 D 272631 CDS NP_301522.1 15827259 909413 763032..763358 1 NC_002677.1 hypothetical protein 763358 909413 ML0630 Mycobacterium leprae TN hypothetical protein NP_301522.1 763032 D 272631 CDS NP_301523.1 15827260 910407 763476..764384 1 NC_002677.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 764384 era 910407 era Mycobacterium leprae TN GTP-binding protein Era NP_301523.1 763476 D 272631 CDS NP_301524.1 15827261 909415 765911..766717 1 NC_002677.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 766717 recO 909415 recO Mycobacterium leprae TN DNA repair protein RecO NP_301524.1 765911 D 272631 CDS NP_301525.1 15827262 909416 766710..767600 1 NC_002677.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 767600 909416 ML0634 Mycobacterium leprae TN undecaprenyl pyrophosphate synthase NP_301525.1 766710 D 272631 CDS NP_301526.1 15827263 909420 769118..771271 1 NC_002677.1 ATP-dependent DNA helicase 771271 uvrD2 909420 uvrD2 Mycobacterium leprae TN ATP-dependent DNA helicase NP_301526.1 769118 D 272631 CDS NP_301527.1 15827264 909421 771426..771728 1 NC_002677.1 hypothetical protein 771728 909421 ML0638 Mycobacterium leprae TN hypothetical protein NP_301527.1 771426 D 272631 CDS NP_301528.1 15827265 909422 771722..771991 1 NC_002677.1 transcriptional regulator 771991 whiB7 909422 whiB7 Mycobacterium leprae TN transcriptional regulator NP_301528.1 771722 D 272631 CDS NP_301529.1 15827266 909423 complement(772068..773489) 1 NC_002677.1 hypothetical protein 773489 909423 ML0640 Mycobacterium leprae TN hypothetical protein NP_301529.1 772068 R 272631 CDS NP_301530.1 15827267 909425 complement(774506..775945) 1 NC_002677.1 hypothetical protein 775945 909425 ML0642 Mycobacterium leprae TN hypothetical protein NP_301530.1 774506 R 272631 CDS NP_301531.1 15827268 909426 776008..777030 1 NC_002677.1 hypothetical protein 777030 909426 ML0643 Mycobacterium leprae TN hypothetical protein NP_301531.1 776008 D 272631 CDS NP_301532.1 15827269 909429 777176..780127 1 NC_002677.1 hypothetical protein 780127 909429 ML0644 Mycobacterium leprae TN hypothetical protein NP_301532.1 777176 D 272631 CDS NP_301533.1 15827270 909452 complement(793592..793873) 1 NC_002677.1 hypothetical protein 793873 909452 ML0656 Mycobacterium leprae TN hypothetical protein NP_301533.1 793592 R 272631 CDS NP_301534.1 15827271 909706 complement(795537..795863) 1 NC_002677.1 hypothetical protein 795863 909706 ML0659 Mycobacterium leprae TN hypothetical protein NP_301534.1 795537 R 272631 CDS NP_301535.1 15827272 909456 complement(796047..797249) 1 NC_002677.1 acyl-CoA dehydrogenase 797249 fadE23 909456 fadE23 Mycobacterium leprae TN acyl-CoA dehydrogenase NP_301535.1 796047 R 272631 CDS NP_301536.1 15827273 910512 complement(797292..798689) 1 NC_002677.1 acyl-CoA dehydrogenase 798689 fadE24 910512 fadE24 Mycobacterium leprae TN acyl-CoA dehydrogenase NP_301536.1 797292 R 272631 CDS NP_301537.1 15827274 909457 complement(798766..799533) 1 NC_002677.1 monophosphatase 799533 909457 ML0662 Mycobacterium leprae TN monophosphatase NP_301537.1 798766 R 272631 CDS NP_301538.1 15827275 910295 799661..799975 1 NC_002677.1 hypothetical protein 799975 910295 ML0663 Mycobacterium leprae TN hypothetical protein NP_301538.1 799661 D 272631 CDS NP_301539.1 15827276 910570 800116..800379 1 NC_002677.1 hypothetical protein 800379 910570 ML0664 Mycobacterium leprae TN hypothetical protein NP_301539.1 800116 D 272631 CDS NP_301540.1 15827277 910559 complement(801976..803346) 1 NC_002677.1 NADPH-ferredoxin reductase 803346 fprA 910559 fprA Mycobacterium leprae TN NADPH-ferredoxin reductase NP_301540.1 801976 R 272631 CDS NP_301541.1 15827278 909702 803526..804650 1 NC_002677.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 804650 prfB 909702 prfB Mycobacterium leprae TN peptide chain release factor 2 NP_301541.1 803526 D 272631 CDS NP_301542.1 15827279 909691 805920..806609 1 NC_002677.1 cell division ATP-binding protein 806609 ftsE 909691 ftsE Mycobacterium leprae TN cell division ATP-binding protein NP_301542.1 805920 D 272631 CDS NP_301543.1 15827280 909655 806610..807503 1 NC_002677.1 hypothetical protein 807503 ftsX 909655 ftsX Mycobacterium leprae TN hypothetical protein NP_301543.1 806610 D 272631 CDS NP_301544.1 15827281 910083 807506..807988 1 NC_002677.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 807988 smpB 910083 smpB Mycobacterium leprae TN SsrA-binding protein NP_301544.1 807506 D 272631 CDS NP_301545.1 15827282 909678 810692..811540 1 NC_002677.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 811540 folD 909678 folD Mycobacterium leprae TN bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_301545.1 810692 D 272631 CDS NP_301546.1 15827283 909684 811543..811818 1 NC_002677.1 hypothetical protein 811818 909684 ML0675 Mycobacterium leprae TN hypothetical protein NP_301546.1 811543 D 272631 CDS NP_301547.1 15827284 909672 complement(811815..812291) 1 NC_002677.1 hypothetical protein 812291 909672 ML0676 Mycobacterium leprae TN hypothetical protein NP_301547.1 811815 R 272631 CDS NP_301548.1 15827285 909687 complement(813432..813959) 1 NC_002677.1 hypothetical protein 813959 909687 ML0678 Mycobacterium leprae TN hypothetical protein NP_301548.1 813432 R 272631 CDS NP_301549.1 15827286 909686 814145..814372 1 NC_002677.1 hypothetical protein 814372 909686 ML0679 Mycobacterium leprae TN hypothetical protein NP_301549.1 814145 D 272631 CDS NP_301550.1 15827287 909449 complement(817109..818257) 1 NC_002677.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 818257 metX 909449 metX Mycobacterium leprae TN homoserine O-acetyltransferase NP_301550.1 817109 R 272631 CDS NP_301551.1 15827288 909572 complement(821179..822090) 1 NC_002677.1 hydrolase 822090 909572 ML0685 Mycobacterium leprae TN hydrolase NP_301551.1 821179 R 272631 CDS NP_301552.1 15827289 909578 822126..823157 1 NC_002677.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 823157 trpS 909578 trpS Mycobacterium leprae TN tryptophanyl-tRNA synthetase NP_301552.1 822126 D 272631 CDS NP_301553.1 15827290 909584 823169..824110 1 NC_002677.1 hypothetical protein 824110 909584 ML0687 Mycobacterium leprae TN hypothetical protein NP_301553.1 823169 D 272631 CDS NP_301554.1 15827291 909585 complement(827877..829112) 1 NC_002677.1 D-alanyl-D-alanine carboxypeptidase 829112 909585 ML0691 Mycobacterium leprae TN D-alanyl-D-alanine carboxypeptidase NP_301554.1 827877 R 272631 CDS NP_301555.1 15827292 909587 complement(833872..834666) 1 NC_002677.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 834666 sdhB 909587 sdhB Mycobacterium leprae TN succinate dehydrogenase iron-sulfur subunit NP_301555.1 833872 R 272631 CDS NP_301556.1 15827293 909594 complement(834666..836420) 1 NC_002677.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 836420 sdhA 909594 sdhA Mycobacterium leprae TN succinate dehydrogenase flavoprotein subunit NP_301556.1 834666 R 272631 CDS NP_301557.1 15827294 909593 complement(836441..836932) 1 NC_002677.1 succinate dehydrogenase hydrophobic membrane anchor protei 836932 sdhD 909593 sdhD Mycobacterium leprae TN succinate dehydrogenase hydrophobic membrane anchor protei NP_301557.1 836441 R 272631 CDS NP_301558.1 15827295 909592 complement(836929..837390) 1 NC_002677.1 succinate dehydrogenase cytochrome B-556 subunit 837390 sdhC 909592 sdhC Mycobacterium leprae TN succinate dehydrogenase cytochrome B-556 subunit NP_301558.1 836929 R 272631 CDS NP_301559.1 15827296 910518 837679..838767 1 NC_002677.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 838767 add 910518 add Mycobacterium leprae TN adenosine deaminase NP_301559.1 837679 D 272631 CDS NP_301560.1 15827297 909630 complement(840882..842153) 1 NC_002677.1 hypothetical protein 842153 909630 ML0703 Mycobacterium leprae TN hypothetical protein NP_301560.1 840882 R 272631 CDS NP_301561.1 15827298 909595 complement(843847..845463) 1 NC_002677.1 phospho-sugar mutase 845463 pmmB 909595 pmmB Mycobacterium leprae TN phospho-sugar mutase NP_301561.1 843847 R 272631 CDS NP_301562.1 15827299 910380 complement(845460..846266) 1 NC_002677.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 846266 deoD 910380 deoD Mycobacterium leprae TN purine nucleoside phosphorylase NP_301562.1 845460 R 272631 CDS NP_301563.1 15827300 909650 complement(849828..850307) 1 NC_002677.1 hypothetical protein 850307 909650 ML0711 Mycobacterium leprae TN hypothetical protein NP_301563.1 849828 R 272631 CDS NP_301564.1 15827301 909648 851948..853705 1 NC_002677.1 glycerol-3-phosphate dehydrogenase 853705 glpD 909648 glpD Mycobacterium leprae TN glycerol-3-phosphate dehydrogenase NP_301564.1 851948 D 272631 CDS NP_301565.1 15827302 909652 854776..855690 1 NC_002677.1 hydrolase 855690 lpqC 909652 lpqC Mycobacterium leprae TN hydrolase NP_301565.1 854776 D 272631 CDS NP_301566.1 15827303 909660 complement(859917..860588) 1 NC_002677.1 TetR family transcriptional regulator 860588 909660 ML0717 Mycobacterium leprae TN TetR family transcriptional regulator NP_301566.1 859917 R 272631 CDS NP_301567.1 15827304 909662 complement(867696..869492) 1 NC_002677.1 acetyl/propionyl CoA carboxylase subunit alpha 869492 bccA 909662 bccA Mycobacterium leprae TN acetyl/propionyl CoA carboxylase subunit alpha NP_301567.1 867696 R 272631 CDS NP_301568.1 15827305 909669 complement(870028..870918) 1 NC_002677.1 thiosulfate sulfurtransferase 870918 sseA 909669 sseA Mycobacterium leprae TN thiosulfate sulfurtransferase NP_301568.1 870028 R 272631 CDS NP_301569.1 15827306 909673 complement(871119..871760) 1 NC_002677.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 871760 maf 909673 maf Mycobacterium leprae TN Maf-like protein NP_301569.1 871119 R 272631 CDS NP_301570.1 15827307 909675 complement(871757..872011) 1 NC_002677.1 Similar to Mycobacterium tuberculosis hypothetical 19.0 kda protein RV3281 OR MTCY71.21 TR:P96886 (EMBL:Z92771) fasta scores: E(): 2.4e-22, 69.0% id in 87 aa. Previously sequenced as TR:Q49671 (EMBL:U00012). Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain.; hypothetical protein 872011 909675 ML0730 Mycobacterium leprae TN hypothetical protein NP_301570.1 871757 R 272631 CDS NP_301571.1 15827308 909674 complement(872008..873657) 1 NC_002677.1 acetyl/propionyl CoA carboxylase subunit beta 873657 accD5 909674 accD5 Mycobacterium leprae TN acetyl/propionyl CoA carboxylase subunit beta NP_301571.1 872008 R 272631 CDS NP_301572.1 15827309 909679 873720..874544 1 NC_002677.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 874544 birA 909679 birA Mycobacterium leprae TN biotin--protein ligase NP_301572.1 873720 D 272631 CDS NP_301573.1 15827310 909677 874677..875195 1 NC_002677.1 hypothetical protein 875195 909677 ML0733 Mycobacterium leprae TN hypothetical protein NP_301573.1 874677 D 272631 CDS NP_301574.1 15827311 909676 complement(875150..875836) 1 NC_002677.1 hypothetical protein 875836 909676 ML0734 Mycobacterium leprae TN hypothetical protein NP_301574.1 875150 R 272631 CDS NP_301575.1 15827312 909683 875924..877243 1 NC_002677.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 877243 purK 909683 purK Mycobacterium leprae TN phosphoribosylaminoimidazole carboxylase ATPase subunit NP_301575.1 875924 D 272631 CDS NP_301576.1 15827313 909681 877243..877758 1 NC_002677.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 877758 purE 909681 purE Mycobacterium leprae TN phosphoribosylaminoimidazole carboxylase catalytic subunit NP_301576.1 877243 D 272631 CDS NP_301577.1 15827314 909685 877853..879022 1 NC_002677.1 acyl-CoA dehydrogenase 879022 fadE25 909685 fadE25 Mycobacterium leprae TN acyl-CoA dehydrogenase NP_301577.1 877853 D 272631 CDS NP_301578.1 15827315 909697 complement(888793..890970) 1 NC_002677.1 cation transport ATPase 890970 ctpC 909697 ctpC Mycobacterium leprae TN cation transport ATPase NP_301578.1 888793 R 272631 CDS NP_301579.1 15827316 909701 complement(890981..891259) 1 NC_002677.1 hypothetical protein 891259 909701 ML0748 Mycobacterium leprae TN hypothetical protein NP_301579.1 890981 R 272631 CDS NP_301580.1 15827317 909705 complement(892063..893532) 1 NC_002677.1 hypothetical protein 893532 909705 ML0750 Mycobacterium leprae TN hypothetical protein NP_301580.1 892063 R 272631 CDS NP_301581.1 15827318 909704 893621..894556 1 NC_002677.1 dTDP-rhamnose modification protein 894556 rmlD 909704 rmlD Mycobacterium leprae TN dTDP-rhamnose modification protein NP_301581.1 893621 D 272631 CDS NP_301582.1 15827319 909703 894549..895475 1 NC_002677.1 dTDP-rhamnosyl transferase 895475 wbbL 909703 wbbL Mycobacterium leprae TN dTDP-rhamnosyl transferase NP_301582.1 894549 D 272631 CDS NP_301583.1 15827320 909707 895477..896553 1 NC_002677.1 sugar-phosphate nucleotidyl transferase 896553 rmlA2 909707 rmlA2 Mycobacterium leprae TN sugar-phosphate nucleotidyl transferase NP_301583.1 895477 D 272631 CDS NP_301584.1 15827321 909709 complement(897493..897753) 1 NC_002677.1 hypothetical protein 897753 909709 ML0755 Mycobacterium leprae TN hypothetical protein NP_301584.1 897493 R 272631 CDS NP_301585.1 15827322 909708 complement(897971..899638) 1 NC_002677.1 DNA methylase 899638 909708 ML0756 Mycobacterium leprae TN DNA methylase NP_301585.1 897971 R 272631 CDS NP_301586.1 15827323 909715 complement(899660..900352) 1 NC_002677.1 hypothetical protein 900352 909715 ML0757 Mycobacterium leprae TN hypothetical protein NP_301586.1 899660 R 272631 CDS NP_301587.1 15827324 909714 complement(900393..901766) 1 NC_002677.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 901766 909714 ML0758 Mycobacterium leprae TN F420-0--gamma-glutamyl ligase NP_301587.1 900393 R 272631 CDS NP_301588.1 15827325 909719 complement(901763..902902) 1 NC_002677.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 902902 909719 ML0759 Mycobacterium leprae TN LPPG:FO 2-phospho-L-lactate transferase NP_301588.1 901763 R 272631 CDS NP_301589.1 15827326 909718 903227..903496 1 NC_002677.1 transcriptional regulator 903496 whiB2 909718 whiB2 Mycobacterium leprae TN transcriptional regulator NP_301589.1 903227 D 272631 CDS NP_301590.1 15827327 909716 complement(903525..904028) 1 NC_002677.1 hypothetical protein 904028 909716 ML0761 Mycobacterium leprae TN hypothetical protein NP_301590.1 903525 R 272631 CDS NP_301591.1 15827328 909717 904068..904565 1 NC_002677.1 hypothetical protein 904565 909717 ML0762 Mycobacterium leprae TN hypothetical protein NP_301591.1 904068 D 272631 CDS NP_301592.1 15827329 909722 904675..906081 1 NC_002677.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 906081 manB 909722 manB Mycobacterium leprae TN phosphomannomutase NP_301592.1 904675 D 272631 CDS NP_301593.1 15827330 909721 906078..907175 1 NC_002677.1 hypothetical protein 907175 909721 ML0764 Mycobacterium leprae TN hypothetical protein NP_301593.1 906078 D 272631 CDS NP_301594.1 15827331 909724 907183..908415 1 NC_002677.1 mannose-6-phosphate isomerase 908415 manA 909724 manA Mycobacterium leprae TN mannose-6-phosphate isomerase NP_301594.1 907183 D 272631 CDS NP_301595.1 15827332 910325 913623..915101 1 NC_002677.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 915101 sahH 910325 sahH Mycobacterium leprae TN S-adenosyl-L-homocysteine hydrolase NP_301595.1 913623 D 272631 CDS NP_301596.1 15827333 909725 915144..915776 1 NC_002677.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 915776 tmk 909725 tmk Mycobacterium leprae TN thymidylate kinase NP_301596.1 915144 D 272631 CDS NP_301597.1 15827334 909727 915869..916555 1 NC_002677.1 two-component response regulator 916555 mtrA 909727 mtrA Mycobacterium leprae TN two-component response regulator NP_301597.1 915869 D 272631 CDS NP_301598.1 15827335 909729 916683..918371 1 NC_002677.1 two-component system sensor kinase 918371 mtrB 909729 mtrB Mycobacterium leprae TN two-component system sensor kinase NP_301598.1 916683 D 272631 CDS NP_301599.1 15827336 909733 918368..920137 1 NC_002677.1 lipoprotein LpqB 920137 lpqB 909733 lpqB Mycobacterium leprae TN lipoprotein LpqB NP_301599.1 918368 D 272631 CDS NP_301600.1 15827337 909732 920258..920515 1 NC_002677.1 Similar to the N-terminal half of Mycobacterium tuberculosis hypothetical 22.5 kDa protein RV3242C OR MTCY20B11.17C TR:O05887 (EMBL:Z95121) fasta scores: E(): 6.8e-18, 78.1% id in 64 aa.; hypothetical protein 920515 909732 ML0776 Mycobacterium leprae TN hypothetical protein NP_301600.1 920258 D 272631 CDS NP_301601.1 15827338 909737 920655..920849 1 NC_002677.1 hypothetical protein 920849 909737 ML0777 Mycobacterium leprae TN hypothetical protein NP_301601.1 920655 D 272631 CDS NP_301602.1 15827339 909736 920953..921642 1 NC_002677.1 hypothetical protein 921642 909736 ML0778 Mycobacterium leprae TN hypothetical protein NP_301602.1 920953 D 272631 CDS NP_301603.1 15827340 909735 921722..924544 1 NC_002677.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 924544 secA 909735 secA Mycobacterium leprae TN preprotein translocase subunit SecA NP_301603.1 921722 D 272631 CDS NP_301604.1 15827341 909739 925681..926163 1 NC_002677.1 hypothetical protein 926163 909739 ML0781 Mycobacterium leprae TN hypothetical protein NP_301604.1 925681 D 272631 CDS NP_301605.1 15827342 909743 926168..927325 1 NC_002677.1 transmembrane transport protein 927325 909743 ML0782 Mycobacterium leprae TN transmembrane transport protein NP_301605.1 926168 D 272631 CDS NP_301606.1 15827343 909747 complement(934528..935511) 1 NC_002677.1 hypothetical protein 935511 909747 ML0791 Mycobacterium leprae TN hypothetical protein NP_301606.1 934528 R 272631 CDS NP_301607.1 15827344 909741 complement(935508..936800) 1 NC_002677.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 936800 aroA 909741 aroA Mycobacterium leprae TN 3-phosphoshikimate 1-carboxyvinyltransferase NP_301607.1 935508 R 272631 CDS NP_301608.1 15827345 909750 936847..937605 1 NC_002677.1 bacteriophage protein 937605 909750 ML0793 Mycobacterium leprae TN bacteriophage protein NP_301608.1 936847 D 272631 CDS NP_301609.1 15827346 909753 942266..942442 1 NC_002677.1 hypothetical protein 942442 909753 ML0796 Mycobacterium leprae TN hypothetical protein NP_301609.1 942266 D 272631 CDS NP_301610.1 15827347 909755 complement(946524..948302) 1 NC_002677.1 hypothetical protein 948302 909755 ML0798 Mycobacterium leprae TN hypothetical protein NP_301610.1 946524 R 272631 CDS NP_301611.1 15827348 909757 complement(949041..949448) 1 NC_002677.1 hypothetical protein 949448 909757 ML0799 Mycobacterium leprae TN hypothetical protein NP_301611.1 949041 R 272631 CDS NP_301612.1 15827349 909760 951814..952053 1 NC_002677.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 952053 909760 ML0802 Mycobacterium leprae TN acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_301612.1 951814 D 272631 CDS NP_301613.1 15827350 909761 952103..953605 1 NC_002677.1 two-component system sensor kinase 953605 909761 ML0803 Mycobacterium leprae TN two-component system sensor kinase NP_301613.1 952103 D 272631 CDS NP_301614.1 15827351 909762 complement(953665..953919) 1 NC_002677.1 transcriptional regulator 953919 whiB1 909762 whiB1 Mycobacterium leprae TN transcriptional regulator NP_301614.1 953665 R 272631 CDS NP_301615.1 15827352 909764 955206..955727 1 NC_002677.1 hypothetical protein 955727 909764 ML0806 Mycobacterium leprae TN hypothetical protein NP_301615.1 955206 D 272631 CDS NP_301616.2 161723269 909766 complement(956155..957315) 1 NC_002677.1 synthesizes isochorismate acid from chorismate; isochorismate synthase 957315 entC 909766 entC Mycobacterium leprae TN isochorismate synthase NP_301616.2 956155 R 272631 CDS NP_301617.1 15827354 909768 complement(958882..960105) 1 NC_002677.1 hypothetical protein 960105 909768 ML0810 Mycobacterium leprae TN hypothetical protein NP_301617.1 958882 R 272631 CDS NP_301618.1 15827355 910320 complement(960117..961751) 1 NC_002677.1 ATP-dependent RNA helicase 961751 rhlE 910320 rhlE Mycobacterium leprae TN ATP-dependent RNA helicase NP_301618.1 960117 R 272631 CDS NP_301619.1 15827356 909771 complement(962707..963294) 1 NC_002677.1 hypothetical protein 963294 909771 ML0813 Mycobacterium leprae TN hypothetical protein NP_301619.1 962707 R 272631 CDS NP_301620.1 15827357 909772 963593..963841 1 NC_002677.1 hypothetical protein 963841 909772 ML0814 Mycobacterium leprae TN hypothetical protein NP_301620.1 963593 D 272631 CDS NP_301621.1 15827358 909773 complement(963828..964514) 1 NC_002677.1 TetR family transcriptional regulator 964514 909773 ML0815 Mycobacterium leprae TN TetR family transcriptional regulator NP_301621.1 963828 R 272631 CDS NP_301622.1 15827359 909774 964701..965726 1 NC_002677.1 hypothetical protein 965726 909774 ML0816 Mycobacterium leprae TN hypothetical protein NP_301622.1 964701 D 272631 CDS NP_301623.1 15827360 909775 965930..967117 1 NC_002677.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 967117 moeZ 909775 moeZ Mycobacterium leprae TN molybdopterin biosynthesis-like protein MoeZ NP_301623.1 965930 D 272631 CDS NP_301624.1 15827361 909776 967172..968065 1 NC_002677.1 hypothetical protein 968065 909776 ML0818 Mycobacterium leprae TN hypothetical protein NP_301624.1 967172 D 272631 CDS NP_301625.1 15827362 909782 complement(977783..978178) 1 NC_002677.1 ferric uptake regulatory protein 978178 furB 909782 furB Mycobacterium leprae TN ferric uptake regulatory protein NP_301625.1 977783 R 272631 CDS NP_301626.1 15827363 909783 complement(978252..978674) 1 NC_002677.1 ArsR family transcriptional regulator 978674 909783 ML0825 Mycobacterium leprae TN ArsR family transcriptional regulator NP_301626.1 978252 R 272631 CDS NP_301627.1 15827364 909851 978841..980232 1 NC_002677.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 980232 glyS 909851 glyS Mycobacterium leprae TN glycyl-tRNA synthetase NP_301627.1 978841 D 272631 CDS NP_301628.1 15827365 909794 986474..987763 1 NC_002677.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 987763 dgt 909794 dgt Mycobacterium leprae TN deoxyguanosinetriphosphate triphosphohydrolase-like protein NP_301628.1 986474 D 272631 CDS NP_301629.1 15827366 909792 988458..990386 1 NC_002677.1 synthesizes RNA primers at the replication forks; DNA primase 990386 dnaG 909792 dnaG Mycobacterium leprae TN DNA primase NP_301629.1 988458 D 272631 CDS NP_301630.1 15827367 909789 complement(990401..990703) 1 NC_002677.1 hypothetical protein 990703 909789 ML0834 Mycobacterium leprae TN hypothetical protein NP_301630.1 990401 R 272631 CDS NP_301631.1 15827368 909800 993882..994265 1 NC_002677.1 hypothetical protein 994265 909800 ML0837 Mycobacterium leprae TN hypothetical protein NP_301631.1 993882 D 272631 CDS NP_301632.1 15827369 909803 complement(995670..996353) 1 NC_002677.1 serine acetyltransferase 996353 cysE 909803 cysE Mycobacterium leprae TN serine acetyltransferase NP_301632.1 995670 R 272631 CDS NP_301633.1 15827370 909810 complement(996356..997288) 1 NC_002677.1 cysteine synthase 997288 cysK 909810 cysK Mycobacterium leprae TN cysteine synthase NP_301633.1 996356 R 272631 CDS NP_301634.1 15827371 909770 complement(997285..998589) 1 NC_002677.1 hypothetical protein 998589 909770 ML0840 Mycobacterium leprae TN hypothetical protein NP_301634.1 997285 R 272631 CDS NP_301635.1 15827372 909812 998972..999895 1 NC_002677.1 major membrane protein I 999895 909812 ML0841 Mycobacterium leprae TN major membrane protein I NP_301635.1 998972 D 272631 CDS NP_301636.1 15827373 909813 1000551..1001786 1 NC_002677.1 hypothetical protein 1001786 909813 ML0842 Mycobacterium leprae TN hypothetical protein NP_301636.1 1000551 D 272631 CDS NP_301637.1 15827374 909819 1002559..1004112 1 NC_002677.1 nitrite extrusion protein 1004112 narK 909819 narK Mycobacterium leprae TN nitrite extrusion protein NP_301637.1 1002559 D 272631 CDS NP_301638.1 15827375 909821 complement(1004100..1004681) 1 NC_002677.1 hypothetical protein 1004681 909821 ML0845 Mycobacterium leprae TN hypothetical protein NP_301638.1 1004100 R 272631 CDS NP_301639.1 15827376 909826 1005906..1008080 1 NC_002677.1 ABC transporter 1008080 909826 ML0848 Mycobacterium leprae TN ABC transporter NP_301639.1 1005906 D 272631 CDS NP_301640.1 15827377 909832 1008077..1008928 1 NC_002677.1 hypothetical protein 1008928 909832 ML0849 Mycobacterium leprae TN hypothetical protein NP_301640.1 1008077 D 272631 CDS NP_301641.1 15827378 909839 1012135..1013130 1 NC_002677.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1013130 ribF 909839 ribF Mycobacterium leprae TN bifunctional riboflavin kinase/FMN adenylyltransferase NP_301641.1 1012135 D 272631 CDS NP_301642.1 15827379 909842 1013248..1013517 1 NC_002677.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1013517 rpsO 909842 rpsO Mycobacterium leprae TN 30S ribosomal protein S15 NP_301642.1 1013248 D 272631 CDS NP_301643.1 15827380 909849 1013839..1016160 1 NC_002677.1 polynucleotide phosphorylase 1016160 gpsI 909849 gpsI Mycobacterium leprae TN polynucleotide phosphorylase NP_301643.1 1013839 D 272631 CDS NP_301644.1 15827381 909854 1016249..1017523 1 NC_002677.1 zinc protease 1017523 pepR 909854 pepR Mycobacterium leprae TN zinc protease NP_301644.1 1016249 D 272631 CDS NP_301645.1 15827382 909853 complement(1019690..1020442) 1 NC_002677.1 hypothetical protein 1020442 909853 ML0857 Mycobacterium leprae TN hypothetical protein NP_301645.1 1019690 R 272631 CDS NP_301646.1 15827383 909865 complement(1020469..1021413) 1 NC_002677.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1021413 lipA 909865 lipA Mycobacterium leprae TN lipoyl synthase NP_301646.1 1020469 R 272631 CDS NP_301647.1 15827384 909866 complement(1021410..1022117) 1 NC_002677.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1022117 lipB 909866 lipB Mycobacterium leprae TN lipoate-protein ligase B NP_301647.1 1021410 R 272631 CDS NP_301648.1 15827385 909856 complement(1022182..1023105) 1 NC_002677.1 hypothetical protein 1023105 909856 ML0860 Mycobacterium leprae TN hypothetical protein NP_301648.1 1022182 R 272631 CDS NP_301649.1 15827386 909857 complement(1023121..1024713) 1 NC_002677.1 E2 component; part of pyruvate dehydrogenase; forms a complex with AceA and LpdC; dihydrolipoamide acetyltransferase 1024713 dlaT 909857 dlaT Mycobacterium leprae TN dihydrolipoamide acetyltransferase NP_301649.1 1023121 R 272631 CDS NP_301650.1 15827387 909858 1024953..1026743 1 NC_002677.1 short chain dehydrogenase 1026743 ephD 909858 ephD Mycobacterium leprae TN short chain dehydrogenase NP_301650.1 1024953 D 272631 CDS NP_301651.1 15827388 909861 1026901..1027215 1 NC_002677.1 hypothetical protein 1027215 909861 ML0863 Mycobacterium leprae TN hypothetical protein NP_301651.1 1026901 D 272631 CDS NP_301652.1 15827389 909860 complement(1027286..1028860) 1 NC_002677.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 1028860 pepA 909860 pepA Mycobacterium leprae TN leucyl aminopeptidase NP_301652.1 1027286 R 272631 CDS NP_301653.1 15827390 908708 1029021..1030124 1 NC_002677.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 1030124 gcvT 908708 gcvT Mycobacterium leprae TN glycine cleavage system aminomethyltransferase T NP_301653.1 1029021 D 272631 CDS NP_301654.1 15827391 909864 1030181..1031287 1 NC_002677.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 1031287 ilvE 909864 ilvE Mycobacterium leprae TN branched-chain amino acid aminotransferase NP_301654.1 1030181 D 272631 CDS NP_301655.1 15827392 909862 complement(1032056..1033111) 1 NC_002677.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1033111 cobT 909862 cobT Mycobacterium leprae TN nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NP_301655.1 1032056 R 272631 CDS NP_301656.1 15827393 909869 complement(1033201..1033575) 1 NC_002677.1 hypothetical protein 1033575 909869 ML0869 Mycobacterium leprae TN hypothetical protein NP_301656.1 1033201 R 272631 CDS NP_301657.1 15827394 909873 1035224..1035580 1 NC_002677.1 hypothetical protein 1035580 909873 ML0871 Mycobacterium leprae TN hypothetical protein NP_301657.1 1035224 D 272631 CDS NP_301658.1 15827395 909872 complement(1035615..1036130) 1 NC_002677.1 hypothetical protein 1036130 909872 ML0872 Mycobacterium leprae TN hypothetical protein NP_301658.1 1035615 R 272631 CDS NP_301659.1 15827396 909871 1036449..1037423 1 NC_002677.1 carbohydrate kinase 1037423 909871 ML0873 Mycobacterium leprae TN carbohydrate kinase NP_301659.1 1036449 D 272631 CDS NP_301660.1 15827397 909875 complement(1037606..1039639) 1 NC_002677.1 asparagine synthetase 1039639 asnB 909875 asnB Mycobacterium leprae TN asparagine synthetase NP_301660.1 1037606 R 272631 CDS NP_301661.1 15827398 909877 1039782..1040843 1 NC_002677.1 cytochrome C oxidase chain II 1040843 ctaC 909877 ctaC Mycobacterium leprae TN cytochrome C oxidase chain II NP_301661.1 1039782 D 272631 CDS NP_301662.1 15827399 909880 1040896..1041315 1 NC_002677.1 hypothetical protein 1041315 909880 ML0876 Mycobacterium leprae TN hypothetical protein NP_301662.1 1040896 D 272631 CDS NP_301663.1 15827400 909879 1041502..1042383 1 NC_002677.1 hypothetical protein 1042383 mmpS3 909879 mmpS3 Mycobacterium leprae TN hypothetical protein NP_301663.1 1041502 D 272631 CDS NP_301664.1 15827401 909876 1042383..1043021 1 NC_002677.1 hypothetical protein 1043021 909876 ML0878 Mycobacterium leprae TN hypothetical protein NP_301664.1 1042383 D 272631 CDS NP_301665.1 15827402 909878 complement(1043155..1044810) 1 NC_002677.1 cytochrome B 1044810 qcrB 909878 qcrB Mycobacterium leprae TN cytochrome B NP_301665.1 1043155 R 272631 CDS NP_301666.1 15827403 909874 complement(1044807..1045991) 1 NC_002677.1 Rieske iron-sulfur reductase component 1045991 qcrA 909874 qcrA Mycobacterium leprae TN Rieske iron-sulfur reductase component NP_301666.1 1044807 R 272631 CDS NP_301667.1 15827404 909882 complement(1045988..1046857) 1 NC_002677.1 cytochrome C reductase cytochrome C component 1046857 qcrC 909882 qcrC Mycobacterium leprae TN cytochrome C reductase cytochrome C component NP_301667.1 1045988 R 272631 CDS NP_301668.1 15827405 909884 complement(1046919..1047527) 1 NC_002677.1 cytochrome C oxidase subunit III 1047527 ctaE 909884 ctaE Mycobacterium leprae TN cytochrome C oxidase subunit III NP_301668.1 1046919 R 272631 CDS NP_301669.1 15827406 909885 1047664..1048764 1 NC_002677.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1048764 trpD 909885 trpD Mycobacterium leprae TN anthranilate phosphoribosyltransferase NP_301669.1 1047664 D 272631 CDS NP_301670.1 15827407 909881 1050963..1052087 1 NC_002677.1 hypothetical protein 1052087 909881 ML0885 Mycobacterium leprae TN hypothetical protein NP_301670.1 1050963 D 272631 CDS NP_301671.1 15827408 909887 1052132..1053286 1 NC_002677.1 glycosyl transferase family protein 1053286 909887 ML0886 Mycobacterium leprae TN glycosyl transferase family protein NP_301671.1 1052132 D 272631 CDS NP_301672.1 15827409 909888 complement(1053283..1055085) 1 NC_002677.1 The C-terminus of the predicted product of; long-chain-fatty-acid-CoA ligase 1055085 909888 ML0887 Mycobacterium leprae TN long-chain-fatty-acid-CoA ligase NP_301672.1 1053283 R 272631 CDS NP_301673.1 15827410 909889 1055260..1055667 1 NC_002677.1 hypothetical protein 1055667 909889 ML0888 Mycobacterium leprae TN hypothetical protein NP_301673.1 1055260 D 272631 CDS NP_301674.1 15827411 909890 1055786..1056220 1 NC_002677.1 hypothetical protein 1056220 909890 ML0889 Mycobacterium leprae TN hypothetical protein NP_301674.1 1055786 D 272631 CDS NP_301675.1 15827412 909892 1056241..1057488 1 NC_002677.1 membrane transporter ATPase 1057488 909892 ML0890 Mycobacterium leprae TN membrane transporter ATPase NP_301675.1 1056241 D 272631 CDS NP_301676.1 15827413 909893 1057485..1057877 1 NC_002677.1 hypothetical protein 1057877 909893 ML0891 Mycobacterium leprae TN hypothetical protein NP_301676.1 1057485 D 272631 CDS NP_301677.1 15827414 909891 1057963..1058697 1 NC_002677.1 acyltransferase 1058697 909891 ML0892 Mycobacterium leprae TN acyltransferase NP_301677.1 1057963 D 272631 CDS NP_301678.1 15827415 908616 complement(1058705..1059991) 1 NC_002677.1 hypothetical protein 1059991 908616 ML0893 Mycobacterium leprae TN hypothetical protein NP_301678.1 1058705 R 272631 CDS NP_301679.1 15827416 909896 1061008..1061523 1 NC_002677.1 hypothetical protein 1061523 909896 ML0895 Mycobacterium leprae TN hypothetical protein NP_301679.1 1061008 D 272631 CDS NP_301680.1 15827417 909897 1061587..1062975 1 NC_002677.1 DAHP synthetase; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase 1062975 aroG 909897 aroG Mycobacterium leprae TN 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase NP_301680.1 1061587 D 272631 CDS NP_301681.1 15827418 909898 complement(1062988..1064190) 1 NC_002677.1 serine-threonine protein kinase 1064190 909898 ML0897 Mycobacterium leprae TN serine-threonine protein kinase NP_301681.1 1062988 R 272631 CDS NP_301682.1 15827419 909899 1064343..1064747 1 NC_002677.1 DNA-binding protein 1064747 909899 ML0898 Mycobacterium leprae TN DNA-binding protein NP_301682.1 1064343 D 272631 CDS NP_301683.1 15827420 909900 complement(1064744..1066261) 1 NC_002677.1 integral-membrane protein 1066261 909900 ML0899 Mycobacterium leprae TN integral-membrane protein NP_301683.1 1064744 R 272631 CDS NP_301684.1 15827421 909903 1067600..1068514 1 NC_002677.1 hypothetical protein 1068514 909903 ML0901 Mycobacterium leprae TN hypothetical protein NP_301684.1 1067600 D 272631 CDS NP_301685.1 15827422 909904 complement(1068511..1069230) 1 NC_002677.1 lipoprotein 1069230 909904 ML0902 Mycobacterium leprae TN lipoprotein NP_301685.1 1068511 R 272631 CDS NP_301686.1 15827423 909906 complement(1069302..1069934) 1 NC_002677.1 hypothetical protein 1069934 909906 ML0903 Mycobacterium leprae TN hypothetical protein NP_301686.1 1069302 R 272631 CDS NP_301687.1 15827424 908710 1070251..1070655 1 NC_002677.1 hypothetical protein 1070655 908710 ML0904 Mycobacterium leprae TN hypothetical protein NP_301687.1 1070251 D 272631 CDS NP_301688.1 15827425 908666 1071028..1071459 1 NC_002677.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 1071459 908666 ML0905 Mycobacterium leprae TN cell division protein MraZ NP_301688.1 1071028 D 272631 CDS NP_301689.1 15827426 909902 1071587..1072705 1 NC_002677.1 S-adenosyl-methyltransferase MraW 1072705 mraW 909902 mraW Mycobacterium leprae TN S-adenosyl-methyltransferase MraW NP_301689.1 1071587 D 272631 CDS NP_301690.1 15827427 909908 1072702..1073835 1 NC_002677.1 hypothetical protein 1073835 909908 ML0907 Mycobacterium leprae TN hypothetical protein NP_301690.1 1072702 D 272631 CDS NP_301691.1 15827428 909909 1073832..1075859 1 NC_002677.1 penicillin-binding protein 2 1075859 pbpB 909909 pbpB Mycobacterium leprae TN penicillin-binding protein 2 NP_301691.1 1073832 D 272631 CDS NP_301692.1 15827429 909910 1076001..1077593 1 NC_002677.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1077593 murE 909910 murE Mycobacterium leprae TN UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_301692.1 1076001 D 272631 CDS NP_301693.1 15827430 909915 1077590..1079143 1 NC_002677.1 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanyl ligase (D-alanine:D-alanine-adding enzyme) 1079143 murF 909915 murF Mycobacterium leprae TN UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanyl ligase (D-alanine:D-alanine-adding enzyme) NP_301693.1 1077590 D 272631 CDS NP_301694.1 15827431 909907 1079140..1080219 1 NC_002677.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1080219 mraY 909907 mraY Mycobacterium leprae TN phospho-N-acetylmuramoyl-pentapeptide- transferase NP_301694.1 1079140 D 272631 CDS NP_301695.1 15827432 909911 1080221..1081693 1 NC_002677.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1081693 murD 909911 murD Mycobacterium leprae TN UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_301695.1 1080221 D 272631 CDS NP_301696.1 15827433 909914 1081700..1083304 1 NC_002677.1 cell division protein FtsW 1083304 ftsW 909914 ftsW Mycobacterium leprae TN cell division protein FtsW NP_301696.1 1081700 D 272631 CDS NP_301697.1 15827434 909917 1083301..1084524 1 NC_002677.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1084524 murG 909917 murG Mycobacterium leprae TN undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_301697.1 1083301 D 272631 CDS NP_301698.1 15827435 909916 1084521..1086008 1 NC_002677.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1086008 murC 909916 murC Mycobacterium leprae TN UDP-N-acetylmuramate--L-alanine ligase NP_301698.1 1084521 D 272631 CDS NP_301699.1 15827436 909913 1086005..1087030 1 NC_002677.1 cell division protein FtsQ 1087030 909913 ML0916 Mycobacterium leprae TN cell division protein FtsQ NP_301699.1 1086005 D 272631 CDS NP_301700.1 15827437 909912 1087296..1088435 1 NC_002677.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1088435 ftsZ 909912 ftsZ Mycobacterium leprae TN cell division protein FtsZ NP_301700.1 1087296 D 272631 CDS NP_301701.1 15827438 909920 1088458..1089207 1 NC_002677.1 hypothetical protein 1089207 909920 ML0918 Mycobacterium leprae TN hypothetical protein NP_301701.1 1088458 D 272631 CDS NP_301702.1 15827439 909919 1089204..1089986 1 NC_002677.1 DNA-binding protein 1089986 909919 ML0919 Mycobacterium leprae TN DNA-binding protein NP_301702.1 1089204 D 272631 CDS NP_301703.1 15827440 909918 1090054..1090686 1 NC_002677.1 hypothetical protein 1090686 909918 ML0920 Mycobacterium leprae TN hypothetical protein NP_301703.1 1090054 D 272631 CDS NP_301704.1 15827441 909921 1090811..1091101 1 NC_002677.1 hypothetical protein 1091101 909921 ML0921 Mycobacterium leprae TN hypothetical protein NP_301704.1 1090811 D 272631 CDS NP_301705.1 15827442 909922 1091348..1092148 1 NC_002677.1 hypothetical protein 1092148 ag84 909922 ag84 Mycobacterium leprae TN hypothetical protein NP_301705.1 1091348 D 272631 CDS NP_301706.1 15827443 909923 1092221..1092613 1 NC_002677.1 hypothetical protein 1092613 909923 ML0923 Mycobacterium leprae TN hypothetical protein NP_301706.1 1092221 D 272631 CDS NP_301707.1 15827444 909848 1094376..1095812 1 NC_002677.1 glutamine synthase class I 1095812 glnA 909848 glnA Mycobacterium leprae TN glutamine synthase class I NP_301707.1 1094376 D 272631 CDS NP_301708.1 15827445 909929 complement(1096064..1096432) 1 NC_002677.1 hypothetical protein 1096432 909929 ML0926 Mycobacterium leprae TN hypothetical protein NP_301708.1 1096064 R 272631 CDS NP_301709.1 15827446 909930 complement(1096524..1096832) 1 NC_002677.1 hypothetical protein 1096832 909930 ML0927 Mycobacterium leprae TN hypothetical protein NP_301709.1 1096524 R 272631 CDS NP_301710.1 15827447 909932 1098053..1098337 1 NC_002677.1 hypothetical protein 1098337 909932 ML0928 Mycobacterium leprae TN hypothetical protein NP_301710.1 1098053 D 272631 CDS NP_301711.1 15827448 909943 1109892..1110188 1 NC_002677.1 hypothetical protein 1110188 909943 ML0938 Mycobacterium leprae TN hypothetical protein NP_301711.1 1109892 D 272631 CDS NP_301712.1 15827449 909944 1110185..1110427 1 NC_002677.1 hypothetical protein 1110427 909944 ML0939 Mycobacterium leprae TN hypothetical protein NP_301712.1 1110185 D 272631 CDS NP_301713.1 15827450 909955 1116230..1116553 1 NC_002677.1 hypothetical protein 1116553 909955 ML0946 Mycobacterium leprae TN hypothetical protein NP_301713.1 1116230 D 272631 CDS NP_301714.1 15827451 909956 complement(1117520..1117777) 1 NC_002677.1 hypothetical protein 1117777 909956 ML0947 Mycobacterium leprae TN hypothetical protein NP_301714.1 1117520 R 272631 CDS NP_301715.1 15827452 909958 complement(1118730..1119143) 1 NC_002677.1 hypothetical protein 1119143 909958 ML0949 Mycobacterium leprae TN hypothetical protein NP_301715.1 1118730 R 272631 CDS NP_301716.1 15827453 909959 complement(1119155..1119355) 1 NC_002677.1 hypothetical protein 1119355 909959 ML0950 Mycobacterium leprae TN hypothetical protein NP_301716.1 1119155 R 272631 CDS NP_301717.1 15827454 909962 1121893..1122132 1 NC_002677.1 hypothetical protein 1122132 909962 ML0953 Mycobacterium leprae TN hypothetical protein NP_301717.1 1121893 D 272631 CDS NP_301718.1 15827455 909964 complement(1123017..1124822) 1 NC_002677.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 1124822 ppdK 909964 ppdK Mycobacterium leprae TN pyruvate phosphate dikinase NP_301718.1 1123017 R 272631 CDS NP_301719.1 15827456 909966 1124867..1125376 1 NC_002677.1 hypothetical protein 1125376 909966 ML0956 Mycobacterium leprae TN hypothetical protein NP_301719.1 1124867 D 272631 CDS NP_301720.1 15827457 909968 complement(1125854..1126228) 1 NC_002677.1 hypothetical protein 1126228 909968 ML0957 Mycobacterium leprae TN hypothetical protein NP_301720.1 1125854 R 272631 CDS NP_301721.1 15827458 909969 1126239..1126670 1 NC_002677.1 hypothetical protein 1126670 909969 ML0958 Mycobacterium leprae TN hypothetical protein NP_301721.1 1126239 D 272631 CDS NP_301722.1 15827459 909970 1126912..1127265 1 NC_002677.1 hypothetical protein 1127265 909970 ML0959 Mycobacterium leprae TN hypothetical protein NP_301722.1 1126912 D 272631 CDS NP_301723.1 15827460 909974 complement(1127777..1130059) 1 NC_002677.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1130059 metE 909974 metE Mycobacterium leprae TN 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase NP_301723.1 1127777 R 272631 CDS NP_301724.1 15827461 909977 1131298..1131762 1 NC_002677.1 hypothetical protein 1131762 909977 ML0963 Mycobacterium leprae TN hypothetical protein NP_301724.1 1131298 D 272631 CDS NP_301725.1 15827462 909978 1131800..1132057 1 NC_002677.1 hypothetical protein 1132057 909978 ML0964 Mycobacterium leprae TN hypothetical protein NP_301725.1 1131800 D 272631 CDS NP_301726.1 15827463 909997 1144496..1147156 1 NC_002677.1 cell division protein 1147156 ftsK 909997 ftsK Mycobacterium leprae TN cell division protein NP_301726.1 1144496 D 272631 CDS NP_301727.1 15827464 909998 complement(1147166..1147708) 1 NC_002677.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 1147708 909998 ML0978 Mycobacterium leprae TN N-acetylglutamate synthase NP_301727.1 1147166 R 272631 CDS NP_301728.1 15827465 909999 1147775..1148356 1 NC_002677.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1148356 909999 ML0979 Mycobacterium leprae TN CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NP_301728.1 1147775 D 272631 CDS NP_301729.1 15827466 910006 complement(1151024..1151518) 1 NC_002677.1 hypothetical protein 1151518 910006 ML0984 Mycobacterium leprae TN hypothetical protein NP_301729.1 1151024 R 272631 CDS NP_301730.1 15827467 910007 1151510..1152688 1 NC_002677.1 glycosyltransferase 1152688 910007 ML0985 Mycobacterium leprae TN glycosyltransferase NP_301730.1 1151510 D 272631 CDS NP_301731.1 15827468 910008 1152702..1152905 1 NC_002677.1 hypothetical protein 1152905 910008 ML0986 Mycobacterium leprae TN hypothetical protein NP_301731.1 1152702 D 272631 CDS NP_301732.1 15827469 910009 1153056..1155191 1 NC_002677.1 RecA protein 1155191 recA 910009 recA Mycobacterium leprae TN RecA protein NP_301732.1 1153056 D 272631 CDS NP_301733.1 15827470 910283 1155157..1155672 1 NC_002677.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1155672 recX 910283 recX Mycobacterium leprae TN recombination regulator RecX NP_301733.1 1155157 D 272631 CDS NP_301734.1 15827471 910281 1155731..1157284 1 NC_002677.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1157284 910281 ML0989 Mycobacterium leprae TN (dimethylallyl)adenosine tRNA methylthiotransferase NP_301734.1 1155731 D 272631 CDS NP_301735.1 15827472 910010 1157281..1157910 1 NC_002677.1 hypothetical protein 1157910 910010 ML0990 Mycobacterium leprae TN hypothetical protein NP_301735.1 1157281 D 272631 CDS NP_301736.1 15827473 910015 1162620..1163318 1 NC_002677.1 hypothetical protein 1163318 910015 ML0994 Mycobacterium leprae TN hypothetical protein NP_301736.1 1162620 D 272631 CDS NP_301737.1 15827474 910017 1163315..1164250 1 NC_002677.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 1164250 miaA 910017 miaA Mycobacterium leprae TN tRNA delta(2)-isopentenylpyrophosphate transferase NP_301737.1 1163315 D 272631 CDS NP_301738.1 15827475 910020 1164317..1165207 1 NC_002677.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1165207 dapF 910020 dapF Mycobacterium leprae TN diaminopimelate epimerase NP_301738.1 1164317 D 272631 CDS NP_301739.1 15827476 910021 1165270..1166736 1 NC_002677.1 ATP/GTP-binding protein 1166736 910021 ML0997 Mycobacterium leprae TN ATP/GTP-binding protein NP_301739.1 1165270 D 272631 CDS NP_301740.1 15827477 910031 complement(1172599..1172874) 1 NC_002677.1 hypothetical protein 1172874 910031 ML1001 Mycobacterium leprae TN hypothetical protein NP_301740.1 1172599 R 272631 CDS NP_301741.1 15827478 910047 1172919..1174982 1 NC_002677.1 hypothetical protein 1174982 910047 ML1002 Mycobacterium leprae TN hypothetical protein NP_301741.1 1172919 D 272631 CDS NP_301742.1 15827479 910052 complement(1175021..1175728) 1 NC_002677.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 1175728 lexA 910052 lexA Mycobacterium leprae TN LexA repressor NP_301742.1 1175021 R 272631 CDS NP_301743.1 15827480 910065 1176008..1176502 1 NC_002677.1 hypothetical protein 1176502 910065 ML1004 Mycobacterium leprae TN hypothetical protein NP_301743.1 1176008 D 272631 CDS NP_301744.1 15827481 910064 1176664..1177128 1 NC_002677.1 transcriptional regulator NrdR 1177128 nrdR 910064 nrdR Mycobacterium leprae TN transcriptional regulator NrdR NP_301744.1 1176664 D 272631 CDS NP_301745.1 15827482 909391 1177170..1177655 1 NC_002677.1 hypothetical protein 1177655 909391 ML1006 Mycobacterium leprae TN hypothetical protein NP_301745.1 1177170 D 272631 CDS NP_301746.1 15827483 910071 complement(1179519..1180499) 1 NC_002677.1 hypothetical protein 1180499 910071 ML1009 Mycobacterium leprae TN hypothetical protein NP_301746.1 1179519 R 272631 CDS NP_301747.1 15827484 910070 complement(1180776..1181018) 1 NC_002677.1 hypothetical protein 1181018 910070 ML1010 Mycobacterium leprae TN hypothetical protein NP_301747.1 1180776 R 272631 CDS NP_301748.1 15827485 910068 complement(1181058..1181480) 1 NC_002677.1 hypothetical protein 1181480 910068 ML1011 Mycobacterium leprae TN hypothetical protein NP_301748.1 1181058 R 272631 CDS NP_301749.1 15827486 910073 complement(1183481..1184173) 1 NC_002677.1 iron dependent repressor 1184173 910073 ML1013 Mycobacterium leprae TN iron dependent repressor NP_301749.1 1183481 R 272631 CDS NP_301750.1 15827487 910072 complement(1184330..1185289) 1 NC_002677.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 1185289 910072 ML1014 Mycobacterium leprae TN RNA polymerase sigma factor SigB NP_301750.1 1184330 R 272631 CDS NP_301751.1 15827488 910076 complement(1185456..1185875) 1 NC_002677.1 hypothetical protein 1185875 910076 ML1015 Mycobacterium leprae TN hypothetical protein NP_301751.1 1185456 R 272631 CDS NP_301752.1 15827489 910075 1185903..1186226 1 NC_002677.1 hypothetical protein 1186226 910075 ML1016 Mycobacterium leprae TN hypothetical protein NP_301752.1 1185903 D 272631 CDS NP_301753.1 15827490 910074 complement(1186213..1187205) 1 NC_002677.1 hypothetical protein 1187205 910074 ML1017 Mycobacterium leprae TN hypothetical protein NP_301753.1 1186213 R 272631 CDS NP_301754.1 15827491 910079 complement(1187210..1187425) 1 NC_002677.1 hypothetical protein 1187425 910079 ML1018 Mycobacterium leprae TN hypothetical protein NP_301754.1 1187210 R 272631 CDS NP_301755.1 15827492 910077 complement(1189185..1190909) 1 NC_002677.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 1190909 rpoT 910077 rpoT Mycobacterium leprae TN RNA polymerase sigma factor NP_301755.1 1189185 R 272631 CDS NP_301756.1 15827493 910085 complement(1190920..1191894) 1 NC_002677.1 polyphosphate glucokinase 1191894 ppgK 910085 ppgK Mycobacterium leprae TN polyphosphate glucokinase NP_301756.1 1190920 R 272631 CDS NP_301757.1 15827494 910084 1191843..1192718 1 NC_002677.1 inositol monophosphatase 1192718 suhB 910084 suhB Mycobacterium leprae TN inositol monophosphatase NP_301757.1 1191843 D 272631 CDS NP_301758.1 15827495 910089 complement(1192722..1193372) 1 NC_002677.1 hypothetical protein 1193372 910089 ML1025 Mycobacterium leprae TN hypothetical protein NP_301758.1 1192722 R 272631 CDS NP_301759.1 15827496 910088 1193568..1193870 1 NC_002677.1 hypothetical protein 1193870 910088 ML1026 Mycobacterium leprae TN hypothetical protein NP_301759.1 1193568 D 272631 CDS NP_301760.1 15827497 910087 complement(1193875..1194348) 1 NC_002677.1 hypothetical protein 1194348 910087 ML1027 Mycobacterium leprae TN hypothetical protein NP_301760.1 1193875 R 272631 CDS NP_301761.1 15827498 910096 1194374..1194838 1 NC_002677.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 1194838 dut 910096 dut Mycobacterium leprae TN deoxyuridine 5'-triphosphate nucleotidohydrolase NP_301761.1 1194374 D 272631 CDS NP_301762.1 15827499 910106 1194835..1195656 1 NC_002677.1 hypothetical protein 1195656 910106 ML1029 Mycobacterium leprae TN hypothetical protein NP_301762.1 1194835 D 272631 CDS NP_301763.1 15827500 910112 complement(1195701..1196399) 1 NC_002677.1 hypothetical protein 1196399 910112 ML1030 Mycobacterium leprae TN hypothetical protein NP_301763.1 1195701 R 272631 CDS NP_301764.1 15827501 910118 complement(1199237..1200526) 1 NC_002677.1 membrane transporter 1200526 910118 ML1036 Mycobacterium leprae TN membrane transporter NP_301764.1 1199237 R 272631 CDS NP_301765.1 15827502 910119 complement(1200579..1201133) 1 NC_002677.1 hypothetical protein 1201133 910119 ML1037 Mycobacterium leprae TN hypothetical protein NP_301765.1 1200579 R 272631 CDS NP_301766.1 15827503 910120 1201215..1203146 1 NC_002677.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1203146 dxs 910120 dxs Mycobacterium leprae TN 1-deoxy-D-xylulose-5-phosphate synthase NP_301766.1 1201215 D 272631 CDS NP_301767.1 15827504 910122 complement(1205247..1206536) 1 NC_002677.1 hypothetical protein 1206536 910122 ML1040 Mycobacterium leprae TN hypothetical protein NP_301767.1 1205247 R 272631 CDS NP_301768.1 15827505 910123 complement(1206538..1207128) 1 NC_002677.1 hypothetical protein 1207128 910123 ML1041 Mycobacterium leprae TN hypothetical protein NP_301768.1 1206538 R 272631 CDS NP_301769.1 15827506 910092 1208217..1209290 1 NC_002677.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1209290 hemE 910092 hemE Mycobacterium leprae TN uroporphyrinogen decarboxylase NP_301769.1 1208217 D 272631 CDS NP_301770.1 15827507 910131 1209287..1210642 1 NC_002677.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 1210642 hemY 910131 hemY Mycobacterium leprae TN protoporphyrinogen oxidase NP_301770.1 1209287 D 272631 CDS NP_301771.1 15827508 910132 1210648..1211343 1 NC_002677.1 hypothetical protein 1211343 910132 ML1045 Mycobacterium leprae TN hypothetical protein NP_301771.1 1210648 D 272631 CDS NP_301772.1 15827509 910136 1217109..1218539 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1218539 xclC 910136 xclC Mycobacterium leprae TN acyl-CoA synthetase NP_301772.1 1217109 D 272631 CDS NP_301773.1 15827510 909334 complement(1218562..1219827) 1 NC_002677.1 hypothetical protein 1219827 909334 ML1052 Mycobacterium leprae TN hypothetical protein NP_301773.1 1218562 R 272631 CDS NP_301774.1 15827511 910142 1220374..1220673 1 NC_002677.1 hypothetical protein 1220673 910142 ML1053 Mycobacterium leprae TN hypothetical protein NP_301774.1 1220374 D 272631 CDS NP_301775.1 15827512 910144 1221433..1221735 1 NC_002677.1 hypothetical protein 1221735 910144 ML1055 Mycobacterium leprae TN hypothetical protein NP_301775.1 1221433 D 272631 CDS NP_301776.1 15827513 910145 1221787..1222074 1 NC_002677.1 hypothetical protein 1222074 910145 ML1056 Mycobacterium leprae TN hypothetical protein NP_301776.1 1221787 D 272631 CDS NP_301777.1 15827514 910146 1222249..1222602 1 NC_002677.1 hypothetical protein 1222602 910146 ML1057 Mycobacterium leprae TN hypothetical protein NP_301777.1 1222249 D 272631 CDS NP_301778.1 15827515 910147 complement(1222693..1223646) 1 NC_002677.1 transferase 1223646 910147 ML1058 Mycobacterium leprae TN transferase NP_301778.1 1222693 R 272631 CDS NP_301779.1 15827516 910148 1223700..1224764 1 NC_002677.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1224764 dapE 910148 dapE Mycobacterium leprae TN succinyl-diaminopimelate desuccinylase NP_301779.1 1223700 D 272631 CDS NP_301780.1 15827517 910140 1226442..1227005 1 NC_002677.1 hypothetical protein 1227005 910140 ML1061 Mycobacterium leprae TN hypothetical protein NP_301780.1 1226442 D 272631 CDS NP_301781.1 15827518 910150 1228776..1229651 1 NC_002677.1 dihydropteroate synthase 1229651 folP2 910150 folP2 Mycobacterium leprae TN dihydropteroate synthase NP_301781.1 1228776 D 272631 CDS NP_301782.1 15827519 910152 1229648..1230628 1 NC_002677.1 glucosyl-3-phosphoglycerate synthase 1230628 910152 ML1064 Mycobacterium leprae TN glucosyl-3-phosphoglycerate synthase NP_301782.1 1229648 D 272631 CDS NP_301783.1 15827520 910151 1230644..1230988 1 NC_002677.1 hypothetical protein 1230988 910151 ML1065 Mycobacterium leprae TN hypothetical protein NP_301783.1 1230644 D 272631 CDS NP_301784.1 15827521 910461 1230985..1231563 1 NC_002677.1 DNA-3-methyladenine glycosidase I 1231563 tagA 910461 tagA Mycobacterium leprae TN DNA-3-methyladenine glycosidase I NP_301784.1 1230985 D 272631 CDS NP_301785.1 15827522 910153 1231777..1232004 1 NC_002677.1 hypothetical protein 1232004 910153 ML1067 Mycobacterium leprae TN hypothetical protein NP_301785.1 1231777 D 272631 CDS NP_301786.1 15827523 910156 1233349..1234563 1 NC_002677.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1234563 glgC 910156 glgC Mycobacterium leprae TN glucose-1-phosphate adenylyltransferase NP_301786.1 1233349 D 272631 CDS NP_301787.1 15827524 910386 1234637..1235290 1 NC_002677.1 TetR family transcriptional regulator 1235290 910386 ML1070 Mycobacterium leprae TN TetR family transcriptional regulator NP_301787.1 1234637 D 272631 CDS NP_301788.1 15827525 910161 complement(1238386..1239060) 1 NC_002677.1 O-methyltransferase 1239060 910161 ML1075 Mycobacterium leprae TN O-methyltransferase NP_301788.1 1238386 R 272631 CDS NP_301789.1 15827526 910163 1239340..1240131 1 NC_002677.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1240131 sigE 910163 sigE Mycobacterium leprae TN RNA polymerase sigma factor SigE NP_301789.1 1239340 D 272631 CDS NP_301790.1 15827527 910162 1240278..1240697 1 NC_002677.1 hypothetical protein 1240697 910162 ML1077 Mycobacterium leprae TN hypothetical protein NP_301790.1 1240278 D 272631 CDS NP_301791.1 15827528 910155 1240772..1242373 1 NC_002677.1 serine protease 1242373 htrA 910155 htrA Mycobacterium leprae TN serine protease NP_301791.1 1240772 D 272631 CDS NP_301792.1 15827529 910165 1242373..1242735 1 NC_002677.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1242735 910165 ML1079 Mycobacterium leprae TN sec-independent translocase NP_301792.1 1242373 D 272631 CDS NP_301793.1 15827530 910166 complement(1243755..1244906) 1 NC_002677.1 MRP family ATP-binding protein 1244906 mrp 910166 mrp Mycobacterium leprae TN MRP family ATP-binding protein NP_301793.1 1243755 R 272631 CDS NP_301794.1 15827531 910164 1248325..1249731 1 NC_002677.1 solute-binding transport lipoprotein 1249731 910164 ML1086 Mycobacterium leprae TN solute-binding transport lipoprotein NP_301794.1 1248325 D 272631 CDS NP_301795.1 15827532 910174 1249760..1250674 1 NC_002677.1 ABC transporter inner membrane protein 1250674 910174 ML1087 Mycobacterium leprae TN ABC transporter inner membrane protein NP_301795.1 1249760 D 272631 CDS NP_301796.1 15827533 910175 1250664..1251527 1 NC_002677.1 ABC transporter inner membrane protein 1251527 910175 ML1088 Mycobacterium leprae TN ABC transporter inner membrane protein NP_301796.1 1250664 D 272631 CDS NP_301797.1 15827534 910177 1251532..1252710 1 NC_002677.1 ABC transporter ATP-binding protein 1252710 910177 ML1089 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301797.1 1251532 D 272631 CDS NP_301798.1 15827535 910179 complement(1253339..1254448) 1 NC_002677.1 membrane transporter 1254448 910179 ML1090 Mycobacterium leprae TN membrane transporter NP_301798.1 1253339 R 272631 CDS NP_301799.1 15827536 910180 1254671..1255660 1 NC_002677.1 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1255660 mdh 910180 mdh Mycobacterium leprae TN malate dehydrogenase NP_301799.1 1254671 D 272631 CDS NP_301800.1 15827537 910184 1257729..1258586 1 NC_002677.1 lipoprotein 1258586 910184 ML1093 Mycobacterium leprae TN lipoprotein NP_301800.1 1257729 D 272631 CDS NP_301801.1 15827538 910181 complement(1259132..1259965) 1 NC_002677.1 short chain alcohol dehydrogenase 1259965 910181 ML1094 Mycobacterium leprae TN short chain alcohol dehydrogenase NP_301801.1 1259132 R 272631 CDS NP_301802.2 161723268 910185 complement(1260028..1263744) 1 NC_002677.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 1263744 kgd 910185 kgd Mycobacterium leprae TN alpha-ketoglutarate decarboxylase NP_301802.2 1260028 R 272631 CDS NP_301803.1 15827540 910187 complement(1263932..1264606) 1 NC_002677.1 hypothetical protein 1264606 910187 ML1096 Mycobacterium leprae TN hypothetical protein NP_301803.1 1263932 R 272631 CDS NP_301804.1 15827541 910189 complement(1266648..1270106) 1 NC_002677.1 hypothetical protein 1270106 910189 ML1098 Mycobacterium leprae TN hypothetical protein NP_301804.1 1266648 R 272631 CDS NP_301805.1 15827542 910190 complement(1270157..1270765) 1 NC_002677.1 lipoprotein 1270765 910190 ML1099 Mycobacterium leprae TN lipoprotein NP_301805.1 1270157 R 272631 CDS NP_301806.1 15827543 910191 1272632..1273771 1 NC_002677.1 acyltransferase 1273771 910191 ML1101 Mycobacterium leprae TN acyltransferase NP_301806.1 1272632 D 272631 CDS NP_301807.1 15827544 910193 complement(1276458..1277819) 1 NC_002677.1 oxidoreductase subunit 1277819 910193 ML1103 Mycobacterium leprae TN oxidoreductase subunit NP_301807.1 1276458 R 272631 CDS NP_301808.1 15827545 910195 1279262..1279951 1 NC_002677.1 hypothetical protein 1279951 910195 ML1105 Mycobacterium leprae TN hypothetical protein NP_301808.1 1279262 D 272631 CDS NP_301809.1 15827546 910196 1280426..1280767 1 NC_002677.1 hypothetical protein 1280767 910196 ML1106 Mycobacterium leprae TN hypothetical protein NP_301809.1 1280426 D 272631 CDS NP_301810.1 15827547 910203 complement(1287737..1289626) 1 NC_002677.1 ABC transporter ATP-binding protein 1289626 910203 ML1113 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301810.1 1287737 R 272631 CDS NP_301811.1 15827548 910204 complement(1289623..1291377) 1 NC_002677.1 ABC transporter ATP-binding protein 1291377 910204 ML1114 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301811.1 1289623 R 272631 CDS NP_301812.1 15827549 910205 1291563..1292129 1 NC_002677.1 lipoprotein 1292129 910205 ML1115 Mycobacterium leprae TN lipoprotein NP_301812.1 1291563 D 272631 CDS NP_301813.1 15827550 910207 1292138..1292701 1 NC_002677.1 lipoprotein 1292701 910207 ML1116 Mycobacterium leprae TN lipoprotein NP_301813.1 1292138 D 272631 CDS NP_301814.1 15827551 910209 complement(1292709..1293194) 1 NC_002677.1 hypothetical protein 1293194 910209 ML1117 Mycobacterium leprae TN hypothetical protein NP_301814.1 1292709 R 272631 CDS NP_301815.1 15827552 910211 1294763..1295914 1 NC_002677.1 hypothetical protein 1295914 910211 ML1119 Mycobacterium leprae TN hypothetical protein NP_301815.1 1294763 D 272631 CDS NP_301816.1 15827553 910212 1295911..1298532 1 NC_002677.1 hypothetical protein 1298532 910212 ML1120 Mycobacterium leprae TN hypothetical protein NP_301816.1 1295911 D 272631 CDS NP_301817.1 15827554 910213 complement(1299720..1301393) 1 NC_002677.1 ABC transporter substrate-binding protein 1301393 910213 ML1121 Mycobacterium leprae TN ABC transporter substrate-binding protein NP_301817.1 1299720 R 272631 CDS NP_301818.1 15827555 910208 complement(1301390..1303219) 1 NC_002677.1 ABC transporter ATP-binding protein 1303219 910208 ML1122 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301818.1 1301390 R 272631 CDS NP_301819.1 15827556 910214 complement(1303216..1304115) 1 NC_002677.1 binding-protein dependent transport protein 1304115 910214 ML1123 Mycobacterium leprae TN binding-protein dependent transport protein NP_301819.1 1303216 R 272631 CDS NP_301820.1 15827557 910216 complement(1304112..1305089) 1 NC_002677.1 binding-protein dependent transport protein 1305089 910216 ML1124 Mycobacterium leprae TN binding-protein dependent transport protein NP_301820.1 1304112 R 272631 CDS NP_301821.1 15827558 910221 1316571..1318223 1 NC_002677.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1318223 argS 910221 argS Mycobacterium leprae TN arginyl-tRNA synthetase NP_301821.1 1316571 D 272631 CDS NP_301822.1 15827559 910222 1318220..1319638 1 NC_002677.1 diaminopimelate decarboxylase 1319638 lysA 910222 lysA Mycobacterium leprae TN diaminopimelate decarboxylase NP_301822.1 1318220 D 272631 CDS NP_301823.1 15827560 910223 1319642..1320967 1 NC_002677.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1320967 hom 910223 hom Mycobacterium leprae TN homoserine dehydrogenase NP_301823.1 1319642 D 272631 CDS NP_301824.1 15827561 910224 1320964..1322046 1 NC_002677.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1322046 thrC 910224 thrC Mycobacterium leprae TN threonine synthase NP_301824.1 1320964 D 272631 CDS NP_301825.1 15827562 910225 1322114..1323061 1 NC_002677.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1323061 thrB 910225 thrB Mycobacterium leprae TN homoserine kinase NP_301825.1 1322114 D 272631 CDS NP_301826.1 15827563 910226 1323331..1325163 1 NC_002677.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1325163 rho 910226 rho Mycobacterium leprae TN transcription termination factor Rho NP_301826.1 1323331 D 272631 CDS NP_301827.1 15827564 910227 1325474..1325728 1 NC_002677.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1325728 rpmE 910227 rpmE Mycobacterium leprae TN 50S ribosomal protein L31 NP_301827.1 1325474 D 272631 CDS NP_301828.1 15827565 910228 1325819..1326904 1 NC_002677.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1326904 prfA 910228 prfA Mycobacterium leprae TN peptide chain release factor 1 NP_301828.1 1325819 D 272631 CDS NP_301829.1 15827566 910229 1326901..1327767 1 NC_002677.1 protoporphyrinogen oxidase 1327767 910229 ML1135 Mycobacterium leprae TN protoporphyrinogen oxidase NP_301829.1 1326901 D 272631 CDS NP_301830.1 15827567 910230 1327807..1328469 1 NC_002677.1 hypothetical protein 1328469 910230 ML1136 Mycobacterium leprae TN hypothetical protein NP_301830.1 1327807 D 272631 CDS NP_301831.1 15827568 910220 1328500..1329699 1 NC_002677.1 glycosyltransferase 1329699 910220 ML1137 Mycobacterium leprae TN glycosyltransferase NP_301831.1 1328500 D 272631 CDS NP_301832.1 15827569 910231 1329962..1330423 1 NC_002677.1 hypothetical protein 1330423 910231 ML1138 Mycobacterium leprae TN hypothetical protein NP_301832.1 1329962 D 272631 CDS NP_301833.1 15827570 910232 1330420..1331175 1 NC_002677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1331175 atpB 910232 atpB Mycobacterium leprae TN ATP synthase F0F1 subunit A NP_301833.1 1330420 D 272631 CDS NP_301834.1 15827571 910234 1331271..1331516 1 NC_002677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1331516 atpE 910234 atpE Mycobacterium leprae TN ATP synthase F0F1 subunit C NP_301834.1 1331271 D 272631 CDS NP_301835.1 15827572 910233 1331538..1332050 1 NC_002677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1332050 atpF 910233 atpF Mycobacterium leprae TN ATP synthase F0F1 subunit B NP_301835.1 1331538 D 272631 CDS NP_301836.1 15827573 910235 1332056..1333396 1 NC_002677.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1333396 atpH 910235 atpH Mycobacterium leprae TN ATP synthase F0F1 subunit delta NP_301836.1 1332056 D 272631 CDS NP_301837.1 15827574 910237 1333458..1335134 1 NC_002677.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1335134 atpA 910237 atpA Mycobacterium leprae TN ATP synthase F0F1 subunit alpha NP_301837.1 1333458 D 272631 CDS NP_301838.1 15827575 910238 1335152..1336048 1 NC_002677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1336048 atpG 910238 atpG Mycobacterium leprae TN ATP synthase F0F1 subunit gamma NP_301838.1 1335152 D 272631 CDS NP_301839.1 15827576 910239 1336075..1337532 1 NC_002677.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1337532 atpD 910239 atpD Mycobacterium leprae TN ATP synthase F0F1 subunit beta NP_301839.1 1336075 D 272631 CDS NP_301840.1 15827577 910240 1337565..1337930 1 NC_002677.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1337930 atpC 910240 atpC Mycobacterium leprae TN ATP synthase F0F1 subunit epsilon NP_301840.1 1337565 D 272631 CDS NP_301841.1 15827578 910241 1337937..1338380 1 NC_002677.1 hypothetical protein 1338380 910241 ML1147 Mycobacterium leprae TN hypothetical protein NP_301841.1 1337937 D 272631 CDS NP_301842.1 15827579 910242 complement(1338519..1338674) 1 NC_002677.1 hypothetical protein 1338674 910242 ML1148 Mycobacterium leprae TN hypothetical protein NP_301842.1 1338519 R 272631 CDS NP_301843.1 15827580 910243 complement(1338887..1339462) 1 NC_002677.1 hypothetical protein 1339462 910243 ML1149 Mycobacterium leprae TN hypothetical protein NP_301843.1 1338887 R 272631 CDS NP_301844.1 15827581 910244 1339580..1340836 1 NC_002677.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1340836 murA 910244 murA Mycobacterium leprae TN UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_301844.1 1339580 D 272631 CDS NP_301845.1 15827582 910248 complement(1346360..1346857) 1 NC_002677.1 methylated-DNA--protein-cysteine methyltransferase 1346857 ogt 910248 ogt Mycobacterium leprae TN methylated-DNA--protein-cysteine methyltransferase NP_301845.1 1346360 R 272631 CDS NP_301846.1 15827583 910253 1351359..1352021 1 NC_002677.1 hypothetical protein 1352021 910253 ML1155 Mycobacterium leprae TN hypothetical protein NP_301846.1 1351359 D 272631 CDS NP_301847.1 15827584 910255 complement(1352353..1352820) 1 NC_002677.1 hypothetical protein 1352820 910255 ML1157 Mycobacterium leprae TN hypothetical protein NP_301847.1 1352353 R 272631 CDS NP_301848.1 15827585 910257 1352912..1354093 1 NC_002677.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1354093 fadA4 910257 fadA4 Mycobacterium leprae TN acetyl-CoA acetyltransferase NP_301848.1 1352912 D 272631 CDS NP_301849.1 15827586 910259 1354280..1355185 1 NC_002677.1 hypothetical protein 1355185 910259 ML1159 Mycobacterium leprae TN hypothetical protein NP_301849.1 1354280 D 272631 CDS NP_301850.1 15827587 910263 1364612..1364938 1 NC_002677.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1364938 clpS 910263 clpS Mycobacterium leprae TN ATP-dependent Clp protease adaptor protein ClpS NP_301850.1 1364612 D 272631 CDS NP_301851.1 15827588 910264 1364964..1365551 1 NC_002677.1 hypothetical protein 1365551 910264 ML1166 Mycobacterium leprae TN hypothetical protein NP_301851.1 1364964 D 272631 CDS NP_301852.1 15827589 910265 1365551..1366639 1 NC_002677.1 hydrolase 1366639 910265 ML1167 Mycobacterium leprae TN hydrolase NP_301852.1 1365551 D 272631 CDS NP_301853.1 15827590 910269 1368492..1369208 1 NC_002677.1 hypothetical protein 1369208 910269 ML1171 Mycobacterium leprae TN hypothetical protein NP_301853.1 1368492 D 272631 CDS NP_301854.1 15827591 910270 1369205..1370023 1 NC_002677.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1370023 murI 910270 murI Mycobacterium leprae TN glutamate racemase NP_301854.1 1369205 D 272631 CDS NP_301855.1 15827592 910271 1370096..1370878 1 NC_002677.1 hypothetical protein 1370878 910271 ML1173 Mycobacterium leprae TN hypothetical protein NP_301855.1 1370096 D 272631 CDS NP_301856.1 15827593 910272 1370968..1371747 1 NC_002677.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1371747 rph 910272 rph Mycobacterium leprae TN ribonuclease PH NP_301856.1 1370968 D 272631 CDS NP_301857.1 15827594 910273 1371782..1372444 1 NC_002677.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1372444 910273 ML1175 Mycobacterium leprae TN deoxyribonucleotide triphosphate pyrophosphatase NP_301857.1 1371782 D 272631 CDS NP_301858.1 15827595 910274 complement(1372485..1372844) 1 NC_002677.1 hypothetical protein 1372844 910274 ML1176 Mycobacterium leprae TN hypothetical protein NP_301858.1 1372485 R 272631 CDS NP_301859.1 15827596 910275 complement(1372841..1373221) 1 NC_002677.1 lipoprotein 1373221 910275 ML1177 Mycobacterium leprae TN lipoprotein NP_301859.1 1372841 R 272631 CDS NP_301860.1 15827597 910279 complement(1380300..1380587) 1 NC_002677.1 hypothetical protein 1380587 910279 ML1180 Mycobacterium leprae TN hypothetical protein NP_301860.1 1380300 R 272631 CDS NP_301861.1 15827598 910280 complement(1380639..1380941) 1 NC_002677.1 hypothetical protein 1380941 910280 ML1181 Mycobacterium leprae TN hypothetical protein NP_301861.1 1380639 R 272631 CDS NP_301862.1 15827599 910282 complement(1381004..1382269) 1 NC_002677.1 PPE family protein 1382269 910282 ML1182 Mycobacterium leprae TN PPE family protein NP_301862.1 1381004 R 272631 CDS NP_301863.1 15827600 910285 complement(1382326..1382625) 1 NC_002677.1 hypothetical protein 1382625 910285 ML1183 Mycobacterium leprae TN hypothetical protein NP_301863.1 1382326 R 272631 CDS NP_301864.1 15827601 910291 complement(1386776..1387078) 1 NC_002677.1 hypothetical protein 1387078 910291 ML1186 Mycobacterium leprae TN hypothetical protein NP_301864.1 1386776 R 272631 CDS NP_301865.1 15827602 910289 complement(1390595..1390855) 1 NC_002677.1 hypothetical protein 1390855 910289 ML1188 Mycobacterium leprae TN hypothetical protein NP_301865.1 1390595 R 272631 CDS NP_301866.1 15827603 910287 complement(1392493..1392876) 1 NC_002677.1 hypothetical protein 1392876 910287 ML1189 Mycobacterium leprae TN hypothetical protein NP_301866.1 1392493 R 272631 CDS NP_301867.1 15827604 910286 1395291..1396010 1 NC_002677.1 hypothetical protein 1396010 910286 ML1190 Mycobacterium leprae TN hypothetical protein NP_301867.1 1395291 D 272631 CDS NP_301868.1 15827605 910284 1396622..1405852 1 NC_002677.1 fatty acid synthase 1405852 fas 910284 fas Mycobacterium leprae TN fatty acid synthase NP_301868.1 1396622 D 272631 CDS NP_301869.1 15827606 910293 1405881..1406273 1 NC_002677.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1406273 acpS 910293 acpS Mycobacterium leprae TN 4'-phosphopantetheinyl transferase NP_301869.1 1405881 D 272631 CDS NP_301870.1 15827607 910294 1406363..1407691 1 NC_002677.1 hypothetical protein 1407691 910294 ML1193 Mycobacterium leprae TN hypothetical protein NP_301870.1 1406363 D 272631 CDS NP_301871.1 15827608 910297 1410785..1413964 1 NC_002677.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1413964 ileS 910297 ileS Mycobacterium leprae TN isoleucyl-tRNA synthetase NP_301871.1 1410785 D 272631 CDS NP_301872.1 15827609 910300 complement(1416022..1416954) 1 NC_002677.1 L-asparaginase/L-glutaminase 1416954 ansA 910300 ansA Mycobacterium leprae TN L-asparaginase/L-glutaminase NP_301872.1 1416022 R 272631 CDS NP_301873.1 15827610 910324 1417029..1417634 1 NC_002677.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1417634 lspA 910324 lspA Mycobacterium leprae TN lipoprotein signal peptidase NP_301873.1 1417029 D 272631 CDS NP_301874.1 15827611 910304 1417753..1418679 1 NC_002677.1 pseudouridine synthase 1418679 910304 ML1200 Mycobacterium leprae TN pseudouridine synthase NP_301874.1 1417753 D 272631 CDS NP_301875.1 15827612 910310 1423014..1426547 1 NC_002677.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1426547 dnaE 910310 dnaE Mycobacterium leprae TN DNA polymerase III subunit alpha NP_301875.1 1423014 D 272631 CDS NP_301876.1 15827613 910312 1428251..1429534 1 NC_002677.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1429534 ilvA 910312 ilvA Mycobacterium leprae TN threonine dehydratase NP_301876.1 1428251 D 272631 CDS NP_301877.1 15827614 910313 1431094..1431279 1 NC_002677.1 hypothetical protein 1431279 910313 ML1210 Mycobacterium leprae TN hypothetical protein NP_301877.1 1431094 D 272631 CDS NP_301878.1 15827615 910316 complement(1434679..1436880) 1 NC_002677.1 hypothetical protein 1436880 910316 ML1213 Mycobacterium leprae TN hypothetical protein NP_301878.1 1434679 R 272631 CDS NP_301879.1 15827616 910318 complement(1437010..1437648) 1 NC_002677.1 p60-family protein 1437648 910318 ML1214 Mycobacterium leprae TN p60-family protein NP_301879.1 1437010 R 272631 CDS NP_301880.1 15827617 910321 1438597..1439907 1 NC_002677.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1439907 bioA 910321 bioA Mycobacterium leprae TN adenosylmethionine-8-amino-7-oxononanoate aminotransferase NP_301880.1 1438597 D 272631 CDS NP_301881.1 15827618 910326 1439914..1441071 1 NC_002677.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1441071 bioF 910326 bioF Mycobacterium leprae TN 8-amino-7-oxononanoate synthase NP_301881.1 1439914 D 272631 CDS NP_301882.1 15827619 910322 1441068..1441748 1 NC_002677.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1441748 bioD 910322 bioD Mycobacterium leprae TN dithiobiotin synthetase NP_301882.1 1441068 D 272631 CDS NP_301883.1 15827620 910327 1442502..1443539 1 NC_002677.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1443539 bioB 910327 bioB Mycobacterium leprae TN biotin synthase NP_301883.1 1442502 D 272631 CDS NP_301884.1 15827621 910329 1443565..1443807 1 NC_002677.1 hypothetical protein 1443807 910329 ML1221 Mycobacterium leprae TN hypothetical protein NP_301884.1 1443565 D 272631 CDS NP_301885.1 15827622 910550 1443804..1444400 1 NC_002677.1 hypothetical protein 1444400 910550 ML1222 Mycobacterium leprae TN hypothetical protein NP_301885.1 1443804 D 272631 CDS NP_301886.1 15827623 910331 complement(1445947..1446666) 1 NC_002677.1 hypothetical protein 1446666 910331 ML1224 Mycobacterium leprae TN hypothetical protein NP_301886.1 1445947 R 272631 CDS NP_301887.1 15827624 910333 1446713..1447771 1 NC_002677.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1447771 nadA 910333 nadA Mycobacterium leprae TN quinolinate synthetase NP_301887.1 1446713 D 272631 CDS NP_301888.1 15827625 910334 1447768..1449351 1 NC_002677.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1449351 nadB 910334 nadB Mycobacterium leprae TN L-aspartate oxidase NP_301888.1 1447768 D 272631 CDS NP_301889.1 15827626 910332 1449348..1450208 1 NC_002677.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1450208 nadC 910332 nadC Mycobacterium leprae TN nicotinate-nucleotide pyrophosphorylase NP_301889.1 1449348 D 272631 CDS NP_301890.1 15827627 910330 1454299..1460655 1 NC_002677.1 mycocerosic acid synthase (polyketide synthase) 1460655 pks3 910330 pks3 Mycobacterium leprae TN mycocerosic acid synthase (polyketide synthase) NP_301890.1 1454299 D 272631 CDS NP_301891.1 15827628 910337 1460736..1462151 1 NC_002677.1 hypothetical protein 1462151 papA3 910337 papA3 Mycobacterium leprae TN hypothetical protein NP_301891.1 1460736 D 272631 CDS NP_301892.1 15827629 910336 1462233..1465184 1 NC_002677.1 large membrane protein 1465184 mmpL10 910336 mmpL10 Mycobacterium leprae TN large membrane protein NP_301892.1 1462233 D 272631 CDS NP_301893.1 15827630 910335 complement(1465612..1466688) 1 NC_002677.1 hypothetical protein 1466688 910335 ML1232 Mycobacterium leprae TN hypothetical protein NP_301893.1 1465612 R 272631 CDS NP_301894.1 15827631 910338 complement(1466853..1467545) 1 NC_002677.1 hypothetical protein 1467545 910338 ML1233 Mycobacterium leprae TN hypothetical protein NP_301894.1 1466853 R 272631 CDS NP_301895.1 15827632 910341 complement(1467575..1469314) 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1469314 910341 ML1234 Mycobacterium leprae TN acyl-CoA synthetase NP_301895.1 1467575 R 272631 CDS NP_301896.1 15827633 910343 1476551..1477435 1 NC_002677.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1477435 910343 ML1241 Mycobacterium leprae TN enoyl-CoA hydratase NP_301896.1 1476551 D 272631 CDS NP_301897.1 15827634 910350 1482133..1482594 1 NC_002677.1 hypothetical protein 1482594 910350 ML1243 Mycobacterium leprae TN hypothetical protein NP_301897.1 1482133 D 272631 CDS NP_301898.1 15827635 910347 1482817..1484292 1 NC_002677.1 hypothetical protein 1484292 910347 ML1244 Mycobacterium leprae TN hypothetical protein NP_301898.1 1482817 D 272631 CDS NP_301899.1 15827636 910344 1484289..1486028 1 NC_002677.1 transferase 1486028 910344 ML1245 Mycobacterium leprae TN transferase NP_301899.1 1484289 D 272631 CDS NP_301900.1 15827637 910352 1486025..1488352 1 NC_002677.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1488352 plsB 910352 plsB Mycobacterium leprae TN glycerol-3-phosphate acyltransferase NP_301900.1 1486025 D 272631 CDS NP_301901.1 15827638 910353 1489170..1490840 1 NC_002677.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1490840 910353 ML1248 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_301901.1 1489170 D 272631 CDS NP_301902.1 15827639 910359 1490899..1495767 1 NC_002677.1 hypothetical protein 1495767 910359 ML1249 Mycobacterium leprae TN hypothetical protein NP_301902.1 1490899 D 272631 CDS NP_301903.1 15827640 910362 complement(1498151..1498537) 1 NC_002677.1 hemoglobin-like, oxygen carrier 1498537 glbO 910362 glbO Mycobacterium leprae TN hemoglobin-like, oxygen carrier NP_301903.1 1498151 R 272631 CDS NP_301904.1 15827641 910364 1498706..1499353 1 NC_002677.1 hypothetical protein 1499353 910364 ML1254 Mycobacterium leprae TN hypothetical protein NP_301904.1 1498706 D 272631 CDS NP_301905.1 15827642 910367 1499768..1500259 1 NC_002677.1 hypothetical protein 1500259 910367 ML1255 Mycobacterium leprae TN hypothetical protein NP_301905.1 1499768 D 272631 CDS NP_301906.1 15827643 910363 1502297..1503646 1 NC_002677.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1503646 hisD 910363 hisD Mycobacterium leprae TN histidinol dehydrogenase NP_301906.1 1502297 D 272631 CDS NP_301907.1 15827644 910368 1503643..1504776 1 NC_002677.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1504776 hisC 910368 hisC Mycobacterium leprae TN histidinol-phosphate aminotransferase NP_301907.1 1503643 D 272631 CDS NP_301908.1 15827645 910348 1504773..1505405 1 NC_002677.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1505405 hisB 910348 hisB Mycobacterium leprae TN imidazoleglycerol-phosphate dehydratase NP_301908.1 1504773 D 272631 CDS NP_301909.1 15827646 910371 1505402..1506022 1 NC_002677.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1506022 hisH 910371 hisH Mycobacterium leprae TN imidazole glycerol phosphate synthase subunit HisH NP_301909.1 1505402 D 272631 CDS NP_301910.1 15827647 910372 1506032..1506769 1 NC_002677.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1506769 hisA 910372 hisA Mycobacterium leprae TN phosphoribosyl isomerase A NP_301910.1 1506032 D 272631 CDS NP_301911.1 15827648 910374 1507577..1508362 1 NC_002677.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1508362 hisF 910374 hisF Mycobacterium leprae TN imidazole glycerol phosphate synthase subunit HisF NP_301911.1 1507577 D 272631 CDS NP_301912.1 15827649 910370 1508359..1508706 1 NC_002677.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1508706 hisI 910370 hisI Mycobacterium leprae TN phosphoribosyl-AMP cyclohydrolase NP_301912.1 1508359 D 272631 CDS NP_301913.1 15827650 910375 1510440..1511534 1 NC_002677.1 antiporter 1511534 910375 ML1267 Mycobacterium leprae TN antiporter NP_301913.1 1510440 D 272631 CDS NP_301914.1 15827651 910378 1512139..1513728 1 NC_002677.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1513728 trpE 910378 trpE Mycobacterium leprae TN anthranilate synthase component I NP_301914.1 1512139 D 272631 CDS NP_301915.1 15827652 910376 1513725..1514522 1 NC_002677.1 hypothetical protein 1514522 910376 ML1270 Mycobacterium leprae TN hypothetical protein NP_301915.1 1513725 D 272631 CDS NP_301916.1 15827653 910382 1514500..1515318 1 NC_002677.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1515318 trpC 910382 trpC Mycobacterium leprae TN indole-3-glycerol phosphate synthase NP_301916.1 1514500 D 272631 CDS NP_301917.1 15827654 910381 1515382..1516635 1 NC_002677.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1516635 trpB 910381 trpB Mycobacterium leprae TN tryptophan synthase subunit beta NP_301917.1 1515382 D 272631 CDS NP_301918.1 15827655 910384 1516632..1517444 1 NC_002677.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1517444 trpA 910384 trpA Mycobacterium leprae TN tryptophan synthase subunit alpha NP_301918.1 1516632 D 272631 CDS NP_301919.1 15827656 910385 1517441..1518433 1 NC_002677.1 transfers the N-acyl diglyceride moeity to the prostepctive N-terminalcysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1518433 910385 ML1274 Mycobacterium leprae TN prolipoprotein diacylglyceryl transferase NP_301919.1 1517441 D 272631 CDS NP_301920.1 15827657 910387 1518430..1518666 1 NC_002677.1 hypothetical protein 1518666 910387 ML1275 Mycobacterium leprae TN hypothetical protein NP_301920.1 1518430 D 272631 CDS NP_301921.1 15827658 910388 1519218..1519658 1 NC_002677.1 hypothetical protein 1519658 910388 ML1276 Mycobacterium leprae TN hypothetical protein NP_301921.1 1519218 D 272631 CDS NP_301922.1 15827659 910389 1519741..1521159 1 NC_002677.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1521159 pykA 910389 pykA Mycobacterium leprae TN pyruvate kinase NP_301922.1 1519741 D 272631 CDS NP_301923.1 15827660 910390 1521266..1522159 1 NC_002677.1 acyl CoA thioesterase II 1522159 tesB 910390 tesB Mycobacterium leprae TN acyl CoA thioesterase II NP_301923.1 1521266 D 272631 CDS NP_301924.1 15827661 910402 1531867..1532484 1 NC_002677.1 two-component response regulatory protein 1532484 910402 ML1286 Mycobacterium leprae TN two-component response regulatory protein NP_301924.1 1531867 D 272631 CDS NP_301925.1 15827662 910406 1536149..1537552 1 NC_002677.1 hypothetical protein 1537552 910406 ML1288 Mycobacterium leprae TN hypothetical protein NP_301925.1 1536149 D 272631 CDS NP_301926.1 15827663 910409 1537584..1538114 1 NC_002677.1 hypothetical protein 1538114 910409 ML1289 Mycobacterium leprae TN hypothetical protein NP_301926.1 1537584 D 272631 CDS NP_301927.1 15827664 910404 complement(1540612..1540854) 1 NC_002677.1 hypothetical protein 1540854 910404 ML1292 Mycobacterium leprae TN hypothetical protein NP_301927.1 1540612 R 272631 CDS NP_301928.1 15827665 910412 complement(1543264..1544337) 1 NC_002677.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1544337 pyrD 910412 pyrD Mycobacterium leprae TN dihydroorotate dehydrogenase 2 NP_301928.1 1543264 R 272631 CDS NP_301929.1 15827666 910416 complement(1544355..1544609) 1 NC_002677.1 hypothetical protein 1544609 910416 ML1294 Mycobacterium leprae TN hypothetical protein NP_301929.1 1544355 R 272631 CDS NP_301930.1 15827667 910417 1545740..1546075 1 NC_002677.1 hypothetical protein 1546075 910417 ML1296 Mycobacterium leprae TN hypothetical protein NP_301930.1 1545740 D 272631 CDS NP_301931.1 15827668 910413 1546116..1546964 1 NC_002677.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 1546964 uppP 910413 uppP Mycobacterium leprae TN UDP pyrophosphate phosphatase NP_301931.1 1546116 D 272631 CDS NP_301932.1 15827669 910410 1546961..1547713 1 NC_002677.1 hypothetical protein 1547713 910410 ML1298 Mycobacterium leprae TN hypothetical protein NP_301932.1 1546961 D 272631 CDS NP_301933.1 15827670 910415 1547791..1548381 1 NC_002677.1 hypothetical protein 1548381 910415 ML1299 Mycobacterium leprae TN hypothetical protein NP_301933.1 1547791 D 272631 CDS NP_301934.1 15827671 910414 1548392..1549180 1 NC_002677.1 hypothetical protein 1549180 910414 ML1300 Mycobacterium leprae TN hypothetical protein NP_301934.1 1548392 D 272631 CDS NP_301935.1 15827672 910420 1549219..1550034 1 NC_002677.1 inositol monophosphatase 1550034 910420 ML1301 Mycobacterium leprae TN inositol monophosphatase NP_301935.1 1549219 D 272631 CDS NP_301936.1 15827673 910422 1550230..1551384 1 NC_002677.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1551384 cysS 910422 cysS Mycobacterium leprae TN cysteinyl-tRNA synthetase NP_301936.1 1550230 D 272631 CDS NP_301937.1 15827674 910423 complement(1552519..1554015) 1 NC_002677.1 L-asparagine permease 1554015 ansP1 910423 ansP1 Mycobacterium leprae TN L-asparagine permease NP_301937.1 1552519 R 272631 CDS NP_301938.1 15827675 910427 complement(1554165..1555682) 1 NC_002677.1 L-asparagine permease 1555682 ansP2 910427 ansP2 Mycobacterium leprae TN L-asparagine permease NP_301938.1 1554165 R 272631 CDS NP_301939.1 15827676 908155 complement(1555819..1556643) 1 NC_002677.1 hypothetical protein 1556643 908155 ML1306 Mycobacterium leprae TN hypothetical protein NP_301939.1 1555819 R 272631 CDS NP_301940.1 15827677 910429 1556851..1560471 1 NC_002677.1 5-methyltetrahydrofolate--homocysteine methyltransferase 1560471 metH 910429 metH Mycobacterium leprae TN 5-methyltetrahydrofolate--homocysteine methyltransferase NP_301940.1 1556851 D 272631 CDS NP_301941.1 15827678 910425 1561966..1562247 1 NC_002677.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 1562247 hisE 910425 hisE Mycobacterium leprae TN phosphoribosyl-ATP pyrophosphatase NP_301941.1 1561966 D 272631 CDS NP_301942.1 15827679 910435 1562244..1563113 1 NC_002677.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1563113 hisG 910435 hisG Mycobacterium leprae TN ATP phosphoribosyltransferase NP_301942.1 1562244 D 272631 CDS NP_301943.1 15827680 910432 complement(1565153..1566037) 1 NC_002677.1 hypothetical protein 1566037 910432 ML1312 Mycobacterium leprae TN hypothetical protein NP_301943.1 1565153 R 272631 CDS NP_301944.1 15827681 910431 1566111..1566956 1 NC_002677.1 hypothetical protein 1566956 910431 ML1313 Mycobacterium leprae TN hypothetical protein NP_301944.1 1566111 D 272631 CDS NP_301945.1 15827682 910436 complement(1567070..1567363) 1 NC_002677.1 hypothetical protein 1567363 910436 ML1314 Mycobacterium leprae TN hypothetical protein NP_301945.1 1567070 R 272631 CDS NP_301946.1 15827683 910437 complement(1567372..1567956) 1 NC_002677.1 lipoprotein 1567956 910437 ML1315 Mycobacterium leprae TN lipoprotein NP_301946.1 1567372 R 272631 CDS NP_301947.1 15827684 910441 1568244..1570073 1 NC_002677.1 ATPase AAA 1570073 910441 ML1316 Mycobacterium leprae TN ATPase AAA NP_301947.1 1568244 D 272631 CDS NP_301948.1 15827685 910444 1573917..1575461 1 NC_002677.1 hypothetical protein 1575461 910444 ML1320 Mycobacterium leprae TN hypothetical protein NP_301948.1 1573917 D 272631 CDS NP_301949.1 15827686 910443 1575493..1575684 1 NC_002677.1 hypothetical protein 1575684 910443 ML1321 Mycobacterium leprae TN hypothetical protein NP_301949.1 1575493 D 272631 CDS NP_301950.1 15827687 910447 1575681..1576556 1 NC_002677.1 proteasome [beta]-type subunit 2 1576556 prcB 910447 prcB Mycobacterium leprae TN proteasome [beta]-type subunit 2 NP_301950.1 1575681 D 272631 CDS NP_301951.1 15827688 910449 1576553..1577350 1 NC_002677.1 proteasome [alpha]-type subunit 1 1577350 prcA 910449 prcA Mycobacterium leprae TN proteasome [alpha]-type subunit 1 NP_301951.1 1576553 D 272631 CDS NP_301952.1 15827689 910446 1579801..1581159 1 NC_002677.1 DNA-binding protein 1581159 910446 ML1328 Mycobacterium leprae TN DNA-binding protein NP_301952.1 1579801 D 272631 CDS NP_301953.1 15827690 910438 1581166..1582161 1 NC_002677.1 hypothetical protein 1582161 910438 ML1329 Mycobacterium leprae TN hypothetical protein NP_301953.1 1581166 D 272631 CDS NP_301954.1 15827691 908553 1582158..1583132 1 NC_002677.1 DNA-binding protein 1583132 908553 ML1330 Mycobacterium leprae TN DNA-binding protein NP_301954.1 1582158 D 272631 CDS NP_301955.2 161723267 910454 1583205..1583471 1 NC_002677.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 1583471 tatA 910454 tatA Mycobacterium leprae TN twin-arginine translocation protein TatA NP_301955.2 1583205 D 272631 CDS NP_301956.1 15827693 910452 1583610..1584470 1 NC_002677.1 membrane transport protein 1584470 910452 ML1332 Mycobacterium leprae TN membrane transport protein NP_301956.1 1583610 D 272631 CDS NP_301957.1 15827694 910456 1584495..1587257 1 NC_002677.1 Ski2 subfamily helicase 1587257 helY 910456 helY Mycobacterium leprae TN Ski2 subfamily helicase NP_301957.1 1584495 D 272631 CDS NP_301958.1 15827695 910457 1587322..1588140 1 NC_002677.1 hypothetical protein 1588140 910457 ML1334 Mycobacterium leprae TN hypothetical protein NP_301958.1 1587322 D 272631 CDS NP_301959.1 15827696 910464 complement(1595449..1596771) 1 NC_002677.1 hypothetical protein 1596771 910464 ML1338 Mycobacterium leprae TN hypothetical protein NP_301959.1 1595449 R 272631 CDS NP_301960.1 15827697 910462 complement(1596791..1598368) 1 NC_002677.1 protease 1598368 910462 ML1339 Mycobacterium leprae TN protease NP_301960.1 1596791 R 272631 CDS NP_301961.1 15827698 910460 complement(1598382..1599188) 1 NC_002677.1 hypothetical protein 1599188 910460 ML1340 Mycobacterium leprae TN hypothetical protein NP_301961.1 1598382 R 272631 CDS NP_301962.1 15827699 910474 complement(1602982..1603242) 1 NC_002677.1 hypothetical protein 1603242 910474 ML1344 Mycobacterium leprae TN hypothetical protein NP_301962.1 1602982 R 272631 CDS NP_301963.1 15827700 910470 1606113..1609121 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1609121 910470 ML1346 Mycobacterium leprae TN acyl-CoA synthetase NP_301963.1 1606113 D 272631 CDS NP_301964.1 15827701 910476 1609114..1609347 1 NC_002677.1 hypothetical protein 1609347 910476 ML1347 Mycobacterium leprae TN hypothetical protein NP_301964.1 1609114 D 272631 CDS NP_301965.1 15827702 910482 1611520..1612164 1 NC_002677.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1612164 910482 ML1351 Mycobacterium leprae TN 3-methyladenine DNA glycosylase NP_301965.1 1611520 D 272631 CDS NP_301966.1 15827703 910480 1612175..1613455 1 NC_002677.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1613455 tyrS 910480 tyrS Mycobacterium leprae TN tyrosyl-tRNA synthetase NP_301966.1 1612175 D 272631 CDS NP_301967.1 15827704 910488 1617916..1618101 1 NC_002677.1 hypothetical protein 1618101 910488 ML1357 Mycobacterium leprae TN hypothetical protein NP_301967.1 1617916 D 272631 CDS NP_301968.1 15827705 910487 1618109..1618918 1 NC_002677.1 cytotoxin/hemolysin 1618918 tlyA 910487 tlyA Mycobacterium leprae TN cytotoxin/hemolysin NP_301968.1 1618109 D 272631 CDS NP_301969.1 15827706 910485 1618915..1619850 1 NC_002677.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1619850 ppnK 910485 ppnK Mycobacterium leprae TN inorganic polyphosphate/ATP-NAD kinase NP_301969.1 1618915 D 272631 CDS NP_301970.1 15827707 910489 1619874..1621637 1 NC_002677.1 recombination and DNA repair 1621637 recN 910489 recN Mycobacterium leprae TN recombination and DNA repair NP_301970.1 1619874 D 272631 CDS NP_301971.1 15827708 910490 1621823..1623004 1 NC_002677.1 hypothetical protein 1623004 910490 ML1361 Mycobacterium leprae TN hypothetical protein NP_301971.1 1621823 D 272631 CDS NP_301972.1 15827709 910492 1623026..1623979 1 NC_002677.1 hypothetical protein 1623979 910492 ML1362 Mycobacterium leprae TN hypothetical protein NP_301972.1 1623026 D 272631 CDS NP_301973.1 15827710 910493 1624152..1625924 1 NC_002677.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1625924 pyrG 910493 pyrG Mycobacterium leprae TN CTP synthetase NP_301973.1 1624152 D 272631 CDS NP_301974.1 15827711 910455 1626538..1627488 1 NC_002677.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1627488 xerD 910455 xerD Mycobacterium leprae TN site-specific tyrosine recombinase XerD NP_301974.1 1626538 D 272631 CDS NP_301975.1 15827712 910494 1628029..1628892 1 NC_002677.1 regulatory protein 1628892 910494 ML1367 Mycobacterium leprae TN regulatory protein NP_301975.1 1628029 D 272631 CDS NP_301976.1 15827713 910496 1628889..1629695 1 NC_002677.1 hypothetical protein 1629695 910496 ML1368 Mycobacterium leprae TN hypothetical protein NP_301976.1 1628889 D 272631 CDS NP_301977.1 15827714 910491 1629743..1630438 1 NC_002677.1 hypothetical protein 1630438 910491 ML1369 Mycobacterium leprae TN hypothetical protein NP_301977.1 1629743 D 272631 CDS NP_301978.1 15827715 910499 1630435..1631208 1 NC_002677.1 pseudouridine synthase 1631208 910499 ML1370 Mycobacterium leprae TN pseudouridine synthase NP_301978.1 1630435 D 272631 CDS NP_301979.1 15827716 910501 1631205..1631876 1 NC_002677.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1631876 cmk 910501 cmk Mycobacterium leprae TN cytidylate kinase NP_301979.1 1631205 D 272631 CDS NP_301980.1 15827717 910500 1631870..1633258 1 NC_002677.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1633258 engA 910500 engA Mycobacterium leprae TN GTP-binding protein EngA NP_301980.1 1631870 D 272631 CDS NP_301981.1 15827718 910509 1645070..1645633 1 NC_002677.1 hypothetical protein 1645633 910509 ML1380 Mycobacterium leprae TN hypothetical protein NP_301981.1 1645070 D 272631 CDS NP_301982.1 15827719 910507 complement(1648220..1650955) 1 NC_002677.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1650955 polA 910507 polA Mycobacterium leprae TN DNA polymerase I NP_301982.1 1648220 R 272631 CDS NP_301983.1 15827720 910498 1652728..1654173 1 NC_002677.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1654173 rpsA 910498 rpsA Mycobacterium leprae TN 30S ribosomal protein S1 NP_301983.1 1652728 D 272631 CDS NP_301984.1 15827721 910513 1654200..1655432 1 NC_002677.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1655432 coaE 910513 coaE Mycobacterium leprae TN dephospho-CoA kinase/protein folding accessory domain-containing protein NP_301984.1 1654200 D 272631 CDS NP_301985.1 15827722 910551 1656225..1656563 1 NC_002677.1 hypothetical protein 1656563 910551 ML1384 Mycobacterium leprae TN hypothetical protein NP_301985.1 1656225 D 272631 CDS NP_301986.1 15827723 910520 1661665..1663761 1 NC_002677.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1663761 uvrB 910520 uvrB Mycobacterium leprae TN excinuclease ABC subunit B NP_301986.1 1661665 D 272631 CDS NP_301987.1 15827724 910522 complement(1665174..1666757) 1 NC_002677.1 hypothetical protein 1666757 910522 ML1389 Mycobacterium leprae TN hypothetical protein NP_301987.1 1665174 R 272631 CDS NP_301988.1 15827725 910523 1667049..1667492 1 NC_002677.1 hypothetical protein 1667492 910523 ML1390 Mycobacterium leprae TN hypothetical protein NP_301988.1 1667049 D 272631 CDS NP_301989.1 15827726 910524 complement(1667501..1668199) 1 NC_002677.1 hypothetical protein 1668199 910524 ML1391 Mycobacterium leprae TN hypothetical protein NP_301989.1 1667501 R 272631 CDS NP_301990.1 15827727 910525 1668337..1671246 1 NC_002677.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1671246 uvrA 910525 uvrA Mycobacterium leprae TN excinuclease ABC subunit A NP_301990.1 1668337 D 272631 CDS NP_301991.1 15827728 910531 complement(1671923..1675042) 1 NC_002677.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1675042 lysS 910531 lysS Mycobacterium leprae TN lysyl-tRNA synthetase NP_301991.1 1671923 R 272631 CDS NP_301992.1 15827729 910530 1675807..1676364 1 NC_002677.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1676364 infC 910530 infC Mycobacterium leprae TN translation initiation factor IF-3 NP_301992.1 1675807 D 272631 CDS NP_301993.1 15827730 910528 1676415..1676609 1 NC_002677.1 50S ribosomal protein L35 1676609 rpmI 910528 rpmI Mycobacterium leprae TN 50S ribosomal protein L35 NP_301993.1 1676415 D 272631 CDS NP_301994.1 15827731 910533 1676663..1677052 1 NC_002677.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1677052 rplT 910533 rplT Mycobacterium leprae TN 50S ribosomal protein L20 NP_301994.1 1676663 D 272631 CDS NP_301995.1 15827732 910536 1677107..1677886 1 NC_002677.1 rRNA methyltransferase 1677886 tsnR 910536 tsnR Mycobacterium leprae TN rRNA methyltransferase NP_301995.1 1677107 D 272631 CDS NP_301996.1 15827733 910534 1679214..1680188 1 NC_002677.1 hypothetical protein 1680188 910534 ML1399 Mycobacterium leprae TN hypothetical protein NP_301996.1 1679214 D 272631 CDS NP_301997.1 15827734 910539 1681037..1682089 1 NC_002677.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1682089 pheS 910539 pheS Mycobacterium leprae TN phenylalanyl-tRNA synthetase subunit alpha NP_301997.1 1681037 D 272631 CDS NP_301998.1 15827735 910543 1682086..1684596 1 NC_002677.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1684596 pheT 910543 pheT Mycobacterium leprae TN phenylalanyl-tRNA synthetase subunit beta NP_301998.1 1682086 D 272631 CDS NP_301999.1 15827736 910545 1687672..1688715 1 NC_002677.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1688715 argC 910545 argC Mycobacterium leprae TN N-acetyl-gamma-glutamyl-phosphate reductase NP_301999.1 1687672 D 272631 CDS NP_302000.1 15827737 910546 1688712..1689935 1 NC_002677.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1689935 argJ 910546 argJ Mycobacterium leprae TN bifunctional ornithine acetyltransferase/N-acetylglutamate synthase NP_302000.1 1688712 D 272631 CDS NP_302001.1 15827738 910547 1689932..1690837 1 NC_002677.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1690837 argB 910547 argB Mycobacterium leprae TN acetylglutamate kinase NP_302001.1 1689932 D 272631 CDS NP_302002.1 15827739 910549 1690889..1692103 1 NC_002677.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1692103 argD 910549 argD Mycobacterium leprae TN acetylornithine aminotransferase NP_302002.1 1690889 D 272631 CDS NP_302003.1 15827740 910548 1692135..1693097 1 NC_002677.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1693097 argF 910548 argF Mycobacterium leprae TN ornithine carbamoyltransferase NP_302003.1 1692135 D 272631 CDS NP_302004.1 15827741 910553 1693100..1693603 1 NC_002677.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1693603 argR 910553 argR Mycobacterium leprae TN arginine repressor ArgR NP_302004.1 1693100 D 272631 CDS NP_302005.1 15827742 910554 1693613..1694812 1 NC_002677.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1694812 argG 910554 argG Mycobacterium leprae TN argininosuccinate synthase NP_302005.1 1693613 D 272631 CDS NP_302006.1 15827743 910552 1694884..1696296 1 NC_002677.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1696296 argH 910552 argH Mycobacterium leprae TN argininosuccinate lyase NP_302006.1 1694884 D 272631 CDS NP_302007.1 15827744 910519 1699648..1700454 1 NC_002677.1 CDP-diacylglycerol pyrophosphatase 1700454 910519 ML1417 Mycobacterium leprae TN CDP-diacylglycerol pyrophosphatase NP_302007.1 1699648 D 272631 CDS NP_302008.1 15827745 910556 complement(1700696..1701244) 1 NC_002677.1 hypothetical protein 1701244 910556 ML1418 Mycobacterium leprae TN hypothetical protein NP_302008.1 1700696 R 272631 CDS NP_302009.1 15827746 910557 complement(1704354..1706045) 1 NC_002677.1 regulatory protein 1706045 910557 ML1419 Mycobacterium leprae TN regulatory protein NP_302009.1 1704354 R 272631 CDS NP_302010.1 15827747 910561 1706391..1706744 1 NC_002677.1 hypothetical protein 1706744 910561 ML1420 Mycobacterium leprae TN hypothetical protein NP_302010.1 1706391 D 272631 CDS NP_302011.1 15827748 910560 complement(1710507..1711496) 1 NC_002677.1 hypothetical protein 1711496 910560 ML1423 Mycobacterium leprae TN hypothetical protein NP_302011.1 1710507 R 272631 CDS NP_302012.1 15827749 910567 complement(1711566..1712636) 1 NC_002677.1 binding-protein-dependent transport protein 1712636 910567 ML1424 Mycobacterium leprae TN binding-protein-dependent transport protein NP_302012.1 1711566 R 272631 CDS NP_302013.1 15827750 910568 complement(1712639..1713490) 1 NC_002677.1 ABC transporter inner membrane protein 1713490 910568 ML1425 Mycobacterium leprae TN ABC transporter inner membrane protein NP_302013.1 1712639 R 272631 CDS NP_302014.1 15827751 909645 complement(1713477..1714436) 1 NC_002677.1 ABC transporter inner membrane protein 1714436 909645 ML1426 Mycobacterium leprae TN ABC transporter inner membrane protein NP_302014.1 1713477 R 272631 CDS NP_302015.1 15827752 910571 complement(1714433..1715770) 1 NC_002677.1 lipoprotein ABC transporter 1715770 910571 ML1427 Mycobacterium leprae TN lipoprotein ABC transporter NP_302015.1 1714433 R 272631 CDS NP_302016.1 15827753 908141 1716924..1717250 1 NC_002677.1 hypothetical protein 1717250 908141 ML1430 Mycobacterium leprae TN hypothetical protein NP_302016.1 1716924 D 272631 CDS NP_302017.1 15827754 909467 1733347..1733682 1 NC_002677.1 hypothetical protein 1733682 909467 ML1439 Mycobacterium leprae TN hypothetical protein NP_302017.1 1733347 D 272631 CDS NP_302018.1 15827755 909468 complement(1733639..1734472) 1 NC_002677.1 glycosyl transferase family protein 1734472 909468 ML1440 Mycobacterium leprae TN glycosyl transferase family protein NP_302018.1 1733639 R 272631 CDS NP_302019.1 15827756 909469 complement(1734469..1736403) 1 NC_002677.1 apolipoprotein N-acyltransferase 1736403 909469 ML1441 Mycobacterium leprae TN apolipoprotein N-acyltransferase NP_302019.1 1734469 R 272631 CDS NP_302020.1 15827757 909472 1738595..1739293 1 NC_002677.1 dienelactone hydrolase 1739293 909472 ML1444 Mycobacterium leprae TN dienelactone hydrolase NP_302020.1 1738595 D 272631 CDS NP_302021.1 15827758 909473 complement(1739651..1739875) 1 NC_002677.1 hypothetical protein 1739875 909473 ML1445 Mycobacterium leprae TN hypothetical protein NP_302021.1 1739651 R 272631 CDS NP_302022.1 15827759 909474 complement(1740098..1740484) 1 NC_002677.1 hypothetical protein 1740484 909474 ML1446 Mycobacterium leprae TN hypothetical protein NP_302022.1 1740098 R 272631 CDS NP_302023.1 15827760 909476 1740904..1741458 1 NC_002677.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 1741458 909476 ML1448 Mycobacterium leprae TN RNA polymerase sigma factor SigC NP_302023.1 1740904 D 272631 CDS NP_302024.1 15827761 909480 complement(1746887..1747561) 1 NC_002677.1 phosphoglycerate mutase 1747561 909480 ML1452 Mycobacterium leprae TN phosphoglycerate mutase NP_302024.1 1746887 R 272631 CDS NP_302025.1 15827762 909481 complement(1747561..1747950) 1 NC_002677.1 hypothetical protein 1747950 909481 ML1453 Mycobacterium leprae TN hypothetical protein NP_302025.1 1747561 R 272631 CDS NP_302026.1 15827763 909482 complement(1747947..1748591) 1 NC_002677.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1748591 nadD 909482 nadD Mycobacterium leprae TN nicotinic acid mononucleotide adenylyltransferase NP_302026.1 1747947 R 272631 CDS NP_302027.1 15827764 909486 complement(1751751..1752980) 1 NC_002677.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1752980 proA 909486 proA Mycobacterium leprae TN gamma-glutamyl phosphate reductase NP_302027.1 1751751 R 272631 CDS NP_302028.1 15827765 909491 complement(1759305..1761347) 1 NC_002677.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1761347 nadE 909491 nadE Mycobacterium leprae TN NAD synthetase NP_302028.1 1759305 R 272631 CDS NP_302029.1 15827766 909492 complement(1761564..1762667) 1 NC_002677.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1762667 proB 909492 proB Mycobacterium leprae TN gamma-glutamyl kinase NP_302029.1 1761564 R 272631 CDS NP_302030.1 15827767 909493 complement(1762671..1764110) 1 NC_002677.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1764110 obgE 909493 obgE Mycobacterium leprae TN GTPase ObgE NP_302030.1 1762671 R 272631 CDS NP_302031.1 15827768 909494 complement(1764225..1764491) 1 NC_002677.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1764491 rpmA 909494 rpmA Mycobacterium leprae TN 50S ribosomal protein L27 NP_302031.1 1764225 R 272631 CDS NP_302032.1 15827769 909495 complement(1764503..1764814) 1 NC_002677.1 50S ribosomal protein L21 1764814 rplU 909495 rplU Mycobacterium leprae TN 50S ribosomal protein L21 NP_302032.1 1764503 R 272631 CDS NP_302033.1 15827770 909496 complement(1765041..1767815) 1 NC_002677.1 ribonuclease 1767815 909496 ML1468 Mycobacterium leprae TN ribonuclease NP_302033.1 1765041 R 272631 CDS NP_302034.1 15827771 909497 complement(1768158..1768568) 1 NC_002677.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1768568 ndk 909497 ndk Mycobacterium leprae TN nucleoside diphosphate kinase NP_302034.1 1768158 R 272631 CDS NP_302035.1 15827772 909498 complement(1768618..1768989) 1 NC_002677.1 hypothetical protein 1768989 909498 ML1470 Mycobacterium leprae TN hypothetical protein NP_302035.1 1768618 R 272631 CDS NP_302036.1 15827773 909499 complement(1768986..1770443) 1 NC_002677.1 folylpolyglutamate synthase 1770443 folC 909499 folC Mycobacterium leprae TN folylpolyglutamate synthase NP_302036.1 1768986 R 272631 CDS NP_302037.1 15827774 909500 complement(1770440..1773100) 1 NC_002677.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1773100 valS 909500 valS Mycobacterium leprae TN valyl-tRNA synthetase NP_302037.1 1770440 R 272631 CDS NP_302038.1 15827775 909505 complement(1779773..1781053) 1 NC_002677.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1781053 clpX 909505 clpX Mycobacterium leprae TN ATP-dependent protease ATP-binding subunit ClpX NP_302038.1 1779773 R 272631 CDS NP_302039.1 15827776 909506 1781326..1782207 1 NC_002677.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 1782207 mmuM 909506 mmuM Mycobacterium leprae TN homocysteine methyltransferase NP_302039.1 1781326 D 272631 CDS NP_302040.1 15827777 909507 complement(1782204..1782848) 1 NC_002677.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1782848 clpP2 909507 clpP2 Mycobacterium leprae TN ATP-dependent Clp protease proteolytic subunit NP_302040.1 1782204 R 272631 CDS NP_302041.1 15827778 909508 complement(1782845..1783519) 1 NC_002677.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1783519 clpP 909508 clpP Mycobacterium leprae TN ATP-dependent Clp protease proteolytic subunit NP_302041.1 1782845 R 272631 CDS NP_302042.1 15827779 909509 complement(1783571..1784980) 1 NC_002677.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1784980 tig 909509 tig Mycobacterium leprae TN trigger factor NP_302042.1 1783571 R 272631 CDS NP_302043.1 15827780 909514 complement(1787386..1787874) 1 NC_002677.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 1787874 909514 ML1484 Mycobacterium leprae TN ribose-5-phosphate isomerase B NP_302043.1 1787386 R 272631 CDS NP_302044.1 15827781 909515 complement(1787915..1788538) 1 NC_002677.1 hypothetical protein 1788538 909515 ML1485 Mycobacterium leprae TN hypothetical protein NP_302044.1 1787915 R 272631 CDS NP_302045.1 15827782 909516 1788670..1791258 1 NC_002677.1 aminopeptidase 1791258 909516 ML1486 Mycobacterium leprae TN aminopeptidase NP_302045.1 1788670 D 272631 CDS NP_302046.1 15827783 909520 complement(1792958..1794061) 1 NC_002677.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 1794061 909520 ML1488 Mycobacterium leprae TN N-succinyldiaminopimelate aminotransferase NP_302046.1 1792958 R 272631 CDS NP_302047.1 15827784 909521 complement(1794099..1794425) 1 NC_002677.1 ferredoxin 1794425 fdxA 909521 fdxA Mycobacterium leprae TN ferredoxin NP_302047.1 1794099 R 272631 CDS NP_302048.1 15827785 909524 complement(1797612..1800203) 1 NC_002677.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 1800203 fbiC 909524 fbiC Mycobacterium leprae TN FO synthase NP_302048.1 1797612 R 272631 CDS NP_302049.1 15827786 909526 complement(1801370..1801723) 1 NC_002677.1 hypothetical protein 1801723 909526 ML1494 Mycobacterium leprae TN hypothetical protein NP_302049.1 1801370 R 272631 CDS NP_302050.1 15827787 909527 complement(1801888..1802814) 1 NC_002677.1 hypothetical protein 1802814 909527 ML1495 Mycobacterium leprae TN hypothetical protein NP_302050.1 1801888 R 272631 CDS NP_302051.1 15827788 909529 complement(1803621..1805474) 1 NC_002677.1 hypothetical protein 1805474 909529 ML1497 Mycobacterium leprae TN hypothetical protein NP_302051.1 1803621 R 272631 CDS NP_302052.1 15827789 909530 complement(1805541..1807427) 1 NC_002677.1 GTP-binding, protein elongation factor 1807427 909530 ML1498 Mycobacterium leprae TN GTP-binding, protein elongation factor NP_302052.1 1805541 R 272631 CDS NP_302053.1 15827790 909536 1815091..1815375 1 NC_002677.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1815375 phhB 909536 phhB Mycobacterium leprae TN pterin-4-alpha-carbinolamine dehydratase NP_302053.1 1815091 D 272631 CDS NP_302054.1 15827791 909537 complement(1815362..1816654) 1 NC_002677.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 1816654 pimE 909537 pimE Mycobacterium leprae TN mannosyltransferase NP_302054.1 1815362 R 272631 CDS NP_302055.1 15827792 909538 1816758..1817306 1 NC_002677.1 hypothetical protein 1817306 909538 ML1505 Mycobacterium leprae TN hypothetical protein NP_302055.1 1816758 D 272631 CDS NP_302056.1 15827793 909539 1817334..1818380 1 NC_002677.1 hypothetical protein 1818380 909539 ML1506 Mycobacterium leprae TN hypothetical protein NP_302056.1 1817334 D 272631 CDS NP_302057.1 15827794 909541 complement(1819557..1820048) 1 NC_002677.1 hypothetical protein 1820048 909541 ML1508 Mycobacterium leprae TN hypothetical protein NP_302057.1 1819557 R 272631 CDS NP_302058.1 15827795 909544 1821243..1821956 1 NC_002677.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1821956 909544 ML1511 Mycobacterium leprae TN NAD-dependent deacetylase NP_302058.1 1821243 D 272631 CDS NP_302059.1 15827796 909545 complement(1822931..1824607) 1 NC_002677.1 hypothetical protein 1824607 909545 ML1512 Mycobacterium leprae TN hypothetical protein NP_302059.1 1822931 R 272631 CDS NP_302060.1 15827797 909546 complement(1824627..1825529) 1 NC_002677.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1825529 dapA 909546 dapA Mycobacterium leprae TN dihydrodipicolinate synthase NP_302060.1 1824627 R 272631 CDS NP_302061.1 15827798 909547 complement(1825645..1826409) 1 NC_002677.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 1826409 thyX 909547 thyX Mycobacterium leprae TN FAD-dependent thymidylate synthase NP_302061.1 1825645 R 272631 CDS NP_302062.1 15827799 909550 complement(1831393..1831674) 1 NC_002677.1 hypothetical protein 1831674 909550 ML1517 Mycobacterium leprae TN hypothetical protein NP_302062.1 1831393 R 272631 CDS NP_302063.1 15827800 909551 complement(1832476..1832973) 1 NC_002677.1 dihydrofolate reductase 1832973 folA 909551 folA Mycobacterium leprae TN dihydrofolate reductase NP_302063.1 1832476 R 272631 CDS NP_302064.1 15827801 909552 complement(1833026..1833826) 1 NC_002677.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1833826 thyA 909552 thyA Mycobacterium leprae TN thymidylate synthase NP_302064.1 1833026 R 272631 CDS NP_302065.1 15827802 909556 complement(1837820..1838110) 1 NC_002677.1 hypothetical protein 1838110 909556 ML1523 Mycobacterium leprae TN hypothetical protein NP_302065.1 1837820 R 272631 CDS NP_302066.1 15827803 909558 complement(1840011..1840466) 1 NC_002677.1 hypothetical protein 1840466 909558 ML1525 Mycobacterium leprae TN hypothetical protein NP_302066.1 1840011 R 272631 CDS NP_302067.1 15827804 909559 complement(1840474..1840956) 1 NC_002677.1 hypothetical protein 1840956 909559 ML1526 Mycobacterium leprae TN hypothetical protein NP_302067.1 1840474 R 272631 CDS NP_302068.1 15827805 909565 1846966..1848081 1 NC_002677.1 L-alanine dehydrogenase 1848081 ald 909565 ald Mycobacterium leprae TN L-alanine dehydrogenase NP_302068.1 1846966 D 272631 CDS NP_302069.1 15827806 909569 complement(1851730..1853562) 1 NC_002677.1 hypothetical protein 1853562 909569 ML1536 Mycobacterium leprae TN hypothetical protein NP_302069.1 1851730 R 272631 CDS NP_302070.1 15827807 909570 complement(1853559..1854764) 1 NC_002677.1 hypothetical protein 1854764 909570 ML1537 Mycobacterium leprae TN hypothetical protein NP_302070.1 1853559 R 272631 CDS NP_302071.1 15827808 909571 complement(1854785..1856488) 1 NC_002677.1 protease 1856488 909571 ML1538 Mycobacterium leprae TN protease NP_302071.1 1854785 R 272631 CDS NP_302072.1 15827809 909577 complement(1856520..1858031) 1 NC_002677.1 hypothetical protein 1858031 909577 ML1539 Mycobacterium leprae TN hypothetical protein NP_302072.1 1856520 R 272631 CDS NP_302073.1 15827810 909597 complement(1858295..1859197) 1 NC_002677.1 hypothetical protein 1859197 909597 ML1540 Mycobacterium leprae TN hypothetical protein NP_302073.1 1858295 R 272631 CDS NP_302074.1 15827811 909600 complement(1862215..1866252) 1 NC_002677.1 SpoIIIE-family membrane protein 1866252 909600 ML1543 Mycobacterium leprae TN SpoIIIE-family membrane protein NP_302074.1 1862215 R 272631 CDS NP_302075.1 15827812 909601 complement(1866369..1867889) 1 NC_002677.1 hypothetical protein 1867889 909601 ML1544 Mycobacterium leprae TN hypothetical protein NP_302075.1 1866369 R 272631 CDS NP_302076.1 15827813 909603 complement(1870999..1871961) 1 NC_002677.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1871961 truB 909603 truB Mycobacterium leprae TN tRNA pseudouridine synthase B NP_302076.1 1870999 R 272631 CDS NP_302077.1 15827814 909604 complement(1871958..1872641) 1 NC_002677.1 hypothetical protein 1872641 909604 ML1547 Mycobacterium leprae TN hypothetical protein NP_302077.1 1871958 R 272631 CDS NP_302078.1 15827815 909605 complement(1872638..1873603) 1 NC_002677.1 hypothetical protein 1873603 909605 ML1548 Mycobacterium leprae TN hypothetical protein NP_302078.1 1872638 R 272631 CDS NP_302079.1 15827816 909610 1877242..1878684 1 NC_002677.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1878684 proS 909610 proS Mycobacterium leprae TN prolyl-tRNA synthetase NP_302079.1 1877242 D 272631 CDS NP_302080.1 15827817 909612 complement(1879669..1880163) 1 NC_002677.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1880163 rbfA 909612 rbfA Mycobacterium leprae TN ribosome-binding factor A NP_302080.1 1879669 R 272631 CDS NP_302081.1 15827818 909613 complement(1880177..1882951) 1 NC_002677.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1882951 infB 909613 infB Mycobacterium leprae TN translation initiation factor IF-2 NP_302081.1 1880177 R 272631 CDS NP_302082.1 15827819 909614 complement(1883016..1883336) 1 NC_002677.1 hypothetical protein 1883336 909614 ML1557 Mycobacterium leprae TN hypothetical protein NP_302082.1 1883016 R 272631 CDS NP_302083.1 15827820 909615 complement(1883536..1884579) 1 NC_002677.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1884579 nusA 909615 nusA Mycobacterium leprae TN transcription elongation factor NusA NP_302083.1 1883536 R 272631 CDS NP_302084.1 15827821 909619 1885239..1885775 1 NC_002677.1 hypothetical protein 1885775 909619 ML1560 Mycobacterium leprae TN hypothetical protein NP_302084.1 1885239 D 272631 CDS NP_302085.1 15827822 909618 1885772..1886269 1 NC_002677.1 hypothetical protein 1886269 909618 ML1561 Mycobacterium leprae TN hypothetical protein NP_302085.1 1885772 D 272631 CDS NP_302086.1 15827823 910126 complement(1886294..1887898) 1 NC_002677.1 transmembrane efflux protein 1887898 910126 ML1562 Mycobacterium leprae TN transmembrane efflux protein NP_302086.1 1886294 R 272631 CDS NP_302087.1 15827824 909636 1898124..1898522 1 NC_002677.1 hypothetical protein 1898522 909636 ML1572 Mycobacterium leprae TN hypothetical protein NP_302087.1 1898124 D 272631 CDS NP_302088.1 15827825 909634 complement(1898983..1899732) 1 NC_002677.1 amidotransferase 1899732 909634 ML1573 Mycobacterium leprae TN amidotransferase NP_302088.1 1898983 R 272631 CDS NP_302089.1 15827826 909631 complement(1900169..1900462) 1 NC_002677.1 hypothetical protein 1900462 909631 ML1575 Mycobacterium leprae TN hypothetical protein NP_302089.1 1900169 R 272631 CDS NP_302090.1 15827827 909624 complement(1900886..1901743) 1 NC_002677.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase 1901743 mapB 909624 mapB Mycobacterium leprae TN methionine aminopeptidase NP_302090.1 1900886 R 272631 CDS NP_302091.1 15827828 909637 complement(1901935..1903761) 1 NC_002677.1 penicillin binding protein 1903761 909637 ML1577 Mycobacterium leprae TN penicillin binding protein NP_302091.1 1901935 R 272631 CDS NP_302092.1 15827829 909640 complement(1905761..1906939) 1 NC_002677.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1906939 ispG 909640 ispG Mycobacterium leprae TN 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_302092.1 1905761 R 272631 CDS NP_302093.1 15827830 909642 complement(1906992..1908206) 1 NC_002677.1 hypothetical protein 1908206 909642 ML1582 Mycobacterium leprae TN hypothetical protein NP_302093.1 1906992 R 272631 CDS NP_302094.1 15827831 909644 complement(1908215..1909435) 1 NC_002677.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1909435 909644 ML1583 Mycobacterium leprae TN 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_302094.1 1908215 R 272631 CDS NP_302095.1 15827832 909643 1909590..1909844 1 NC_002677.1 hypothetical protein 1909844 909643 ML1584 Mycobacterium leprae TN hypothetical protein NP_302095.1 1909590 D 272631 CDS NP_302096.1 15827833 909784 complement(1913897..1914835) 1 NC_002677.1 The C-terminus of this protein is; phosphatidate cytidylyltransferase 1914835 909784 ML1589 Mycobacterium leprae TN phosphatidate cytidylyltransferase NP_302096.1 1913897 R 272631 CDS NP_302097.1 15827834 909787 complement(1914867..1915424) 1 NC_002677.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 1915424 frr 909787 frr Mycobacterium leprae TN ribosome recycling factor NP_302097.1 1914867 R 272631 CDS NP_302098.1 15827835 909788 complement(1915483..1916322) 1 NC_002677.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 1916322 pyrH 909788 pyrH Mycobacterium leprae TN uridylate kinase NP_302098.1 1915483 R 272631 CDS NP_302099.1 15827836 908490 complement(1920913..1922319) 1 NC_002677.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1922319 908490 ML1596 Mycobacterium leprae TN amidase NP_302099.1 1920913 R 272631 CDS NP_302100.1 15827837 909802 complement(1922355..1923185) 1 NC_002677.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1923185 tsf 909802 tsf Mycobacterium leprae TN elongation factor Ts NP_302100.1 1922355 R 272631 CDS NP_302101.1 15827838 909804 complement(1923187..1924020) 1 NC_002677.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1924020 rpsB 909804 rpsB Mycobacterium leprae TN 30S ribosomal protein S2 NP_302101.1 1923187 R 272631 CDS NP_302102.1 15827839 909806 complement(1924844..1925737) 1 NC_002677.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 1925737 xerC 909806 xerC Mycobacterium leprae TN site-specific tyrosine recombinase XerC NP_302102.1 1924844 R 272631 CDS NP_302103.1 15827840 908176 complement(1926754..1927119) 1 NC_002677.1 hypothetical protein 1927119 908176 ML1601 Mycobacterium leprae TN hypothetical protein NP_302103.1 1926754 R 272631 CDS NP_302104.1 15827841 910909 complement(1927803..1928123) 1 NC_002677.1 hypothetical protein 1928123 910909 ML1602 Mycobacterium leprae TN hypothetical protein NP_302104.1 1927803 R 272631 CDS NP_302105.1 15827842 908146 complement(1928376..1928636) 1 NC_002677.1 hypothetical protein 1928636 908146 ML1603 Mycobacterium leprae TN hypothetical protein NP_302105.1 1928376 R 272631 CDS NP_302106.1 15827843 909830 complement(1928846..1929235) 1 NC_002677.1 hypothetical protein 1929235 909830 ML1604 Mycobacterium leprae TN hypothetical protein NP_302106.1 1928846 R 272631 CDS NP_302107.1 15827844 909807 1931206..1931406 1 NC_002677.1 hypothetical protein 1931406 909807 ML1605 Mycobacterium leprae TN hypothetical protein NP_302107.1 1931206 D 272631 CDS NP_302108.1 15827845 909331 complement(1932700..1932990) 1 NC_002677.1 hypothetical protein 1932990 909331 ML1607 Mycobacterium leprae TN hypothetical protein NP_302108.1 1932700 R 272631 CDS NP_302109.1 15827846 909809 complement(1935020..1935325) 1 NC_002677.1 hypothetical protein 1935325 909809 ML1610 Mycobacterium leprae TN hypothetical protein NP_302109.1 1935020 R 272631 CDS NP_302110.1 15827847 909811 complement(1935438..1936160) 1 NC_002677.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1936160 rnhB 909811 rnhB Mycobacterium leprae TN ribonuclease HII NP_302110.1 1935438 R 272631 CDS NP_302111.1 15827848 909308 complement(1936163..1937032) 1 NC_002677.1 ignal peptidase I 1937032 909308 ML1612 Mycobacterium leprae TN ignal peptidase I NP_302111.1 1936163 R 272631 CDS NP_302112.1 15827849 909816 complement(1937112..1937453) 1 NC_002677.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1937453 rplS 909816 rplS Mycobacterium leprae TN 50S ribosomal protein L19 NP_302112.1 1937112 R 272631 CDS NP_302113.1 15827850 909818 complement(1938739..1939455) 1 NC_002677.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1939455 trmD 909818 trmD Mycobacterium leprae TN tRNA (guanine-N(1)-)-methyltransferase NP_302113.1 1938739 R 272631 CDS NP_302114.1 15827851 909820 complement(1939452..1939991) 1 NC_002677.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1939991 rimM 909820 rimM Mycobacterium leprae TN 16S rRNA-processing protein RimM NP_302114.1 1939452 R 272631 CDS NP_302115.1 15827852 909822 complement(1939996..1940238) 1 NC_002677.1 hypothetical protein 1940238 909822 ML1617 Mycobacterium leprae TN hypothetical protein NP_302115.1 1939996 R 272631 CDS NP_302116.1 15827853 909823 complement(1940263..1940745) 1 NC_002677.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1940745 rpsP 909823 rpsP Mycobacterium leprae TN 30S ribosomal protein S16 NP_302116.1 1940263 R 272631 CDS NP_302117.1 15827854 909829 complement(1943801..1945366) 1 NC_002677.1 signal recognition particle protein 1945366 ffh 909829 ffh Mycobacterium leprae TN signal recognition particle protein NP_302117.1 1943801 R 272631 CDS NP_302118.1 15827855 909831 1945505..1947475 1 NC_002677.1 molecular chaperone; heat shock protein 90 1947475 htpG 909831 htpG Mycobacterium leprae TN heat shock protein 90 NP_302118.1 1945505 D 272631 CDS NP_302119.1 15827856 910814 1947637..1949427 1 NC_002677.1 hypothetical protein 1949427 910814 ML1624 Mycobacterium leprae TN hypothetical protein NP_302119.1 1947637 D 272631 CDS NP_302120.1 15827857 910809 complement(1953448..1954740) 1 NC_002677.1 SRP family GTP-binding protein 1954740 910809 ML1628 Mycobacterium leprae TN SRP family GTP-binding protein NP_302120.1 1953448 R 272631 CDS NP_302121.1 15827858 909835 complement(1954854..1958465) 1 NC_002677.1 cell division protein 1958465 smc 909835 smc Mycobacterium leprae TN cell division protein NP_302121.1 1954854 R 272631 CDS NP_302122.1 15827859 909837 complement(1959885..1962899) 1 NC_002677.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 1962899 glnE 909837 glnE Mycobacterium leprae TN bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_302122.1 1959885 R 272631 CDS NP_302123.1 15827860 909840 complement(1962930..1964276) 1 NC_002677.1 glutamine synthase class II 1964276 glnA2 909840 glnA2 Mycobacterium leprae TN glutamine synthase class II NP_302123.1 1962930 R 272631 CDS NP_302124.1 15827861 909841 complement(1964373..1965908) 1 NC_002677.1 hydrolase 1965908 909841 ML1632 Mycobacterium leprae TN hydrolase NP_302124.1 1964373 R 272631 CDS NP_302125.1 15827862 909843 complement(1965983..1967590) 1 NC_002677.1 hydrolase 1967590 909843 ML1633 Mycobacterium leprae TN hydrolase NP_302125.1 1965983 R 272631 CDS NP_302126.1 15827863 909845 1969128..1969988 1 NC_002677.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1969988 panB 909845 panB Mycobacterium leprae TN 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_302126.1 1969128 D 272631 CDS NP_302127.1 15827864 909850 complement(1974010..1975125) 1 NC_002677.1 bifunctional RNase H/acid phosphatase 1975125 909850 ML1637 Mycobacterium leprae TN bifunctional RNase H/acid phosphatase NP_302127.1 1974010 R 272631 CDS NP_302128.1 15827865 909867 complement(1975122..1975820) 1 NC_002677.1 hypothetical protein 1975820 909867 ML1638 Mycobacterium leprae TN hypothetical protein NP_302128.1 1975122 R 272631 CDS NP_302129.1 15827866 909868 complement(1975866..1977023) 1 NC_002677.1 hypothetical protein 1977023 909868 ML1639 Mycobacterium leprae TN hypothetical protein NP_302129.1 1975866 R 272631 CDS NP_302130.1 15827867 909938 1978961..1979773 1 NC_002677.1 hypothetical protein 1979773 909938 ML1644 Mycobacterium leprae TN hypothetical protein NP_302130.1 1978961 D 272631 CDS NP_302131.1 15827868 909967 complement(1987829..1988251) 1 NC_002677.1 hypothetical protein 1988251 909967 ML1649 Mycobacterium leprae TN hypothetical protein NP_302131.1 1987829 R 272631 CDS NP_302132.1 15827869 909973 1989164..1991974 1 NC_002677.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1991974 aceE 909973 aceE Mycobacterium leprae TN pyruvate dehydrogenase subunit E1 NP_302132.1 1989164 D 272631 CDS NP_302133.1 15827870 909979 1992060..1993304 1 NC_002677.1 hypothetical protein 1993304 909979 ML1652 Mycobacterium leprae TN hypothetical protein NP_302133.1 1992060 D 272631 CDS NP_302134.1 15827871 909982 1993515..1994429 1 NC_002677.1 ACP S-malonyltransferase 1994429 fabD 909982 fabD Mycobacterium leprae TN ACP S-malonyltransferase NP_302134.1 1993515 D 272631 CDS NP_302135.1 15827872 909992 1994529..1994876 1 NC_002677.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1994876 acpP 909992 acpP Mycobacterium leprae TN acyl carrier protein NP_302135.1 1994529 D 272631 CDS NP_302136.1 15827873 909994 1994873..1996123 1 NC_002677.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1996123 kasA 909994 kasA Mycobacterium leprae TN 3-oxoacyl-ACP synthase NP_302136.1 1994873 D 272631 CDS NP_302137.1 15827874 910002 1996136..1997413 1 NC_002677.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1997413 kasB 910002 kasB Mycobacterium leprae TN 3-oxoacyl-ACP synthase NP_302137.1 1996136 D 272631 CDS NP_302138.1 15827875 910005 1997444..1998865 1 NC_002677.1 acetyl/propionyl CoA carboxylase subunit beta 1998865 910005 ML1657 Mycobacterium leprae TN acetyl/propionyl CoA carboxylase subunit beta NP_302138.1 1997444 D 272631 CDS NP_302139.1 15827876 910013 complement(1999991..2000839) 1 NC_002677.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 2000839 fpg 910013 fpg Mycobacterium leprae TN formamidopyrimidine-DNA glycosylase NP_302139.1 1999991 R 272631 CDS NP_302140.1 15827877 910019 complement(2000894..2001610) 1 NC_002677.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2001610 rnc 910019 rnc Mycobacterium leprae TN ribonuclease III NP_302140.1 2000894 R 272631 CDS NP_302141.1 15827878 910024 complement(2001607..2002260) 1 NC_002677.1 hypothetical protein 2002260 910024 ML1660 Mycobacterium leprae TN hypothetical protein NP_302141.1 2001607 R 272631 CDS NP_302142.1 15827879 910026 complement(2002294..2003037) 1 NC_002677.1 hypothetical protein 2003037 910026 ML1661 Mycobacterium leprae TN hypothetical protein NP_302142.1 2002294 R 272631 CDS NP_302143.1 15827880 910028 complement(2005132..2005605) 1 NC_002677.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 2005605 coaD 910028 coaD Mycobacterium leprae TN phosphopantetheine adenylyltransferase NP_302143.1 2005132 R 272631 CDS NP_302144.1 15827881 910029 complement(2005637..2006110) 1 NC_002677.1 hypothetical protein 2006110 910029 ML1664 Mycobacterium leprae TN hypothetical protein NP_302144.1 2005637 R 272631 CDS NP_302145.1 15827882 910032 complement(2009601..2010245) 1 NC_002677.1 hypothetical protein 2010245 910032 ML1666 Mycobacterium leprae TN hypothetical protein NP_302145.1 2009601 R 272631 CDS NP_302146.1 15827883 910033 complement(2010254..2011048) 1 NC_002677.1 hypothetical protein 2011048 910033 ML1667 Mycobacterium leprae TN hypothetical protein NP_302146.1 2010254 R 272631 CDS NP_302147.1 15827884 910035 2013056..2013904 1 NC_002677.1 aldo/keto reductase 2013904 910035 ML1669 Mycobacterium leprae TN aldo/keto reductase NP_302147.1 2013056 D 272631 CDS NP_302148.1 15827885 910037 complement(2014723..2016954) 1 NC_002677.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 2016954 recG 910037 recG Mycobacterium leprae TN ATP-dependent DNA helicase RecG NP_302148.1 2014723 R 272631 CDS NP_302149.1 15827886 910041 complement(2019277..2019960) 1 NC_002677.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2019960 ung 910041 ung Mycobacterium leprae TN uracil-DNA glycosylase NP_302149.1 2019277 R 272631 CDS NP_302150.1 15827887 910042 complement(2020074..2021051) 1 NC_002677.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 2021051 thiL 910042 thiL Mycobacterium leprae TN thiamine monophosphate kinase NP_302150.1 2020074 R 272631 CDS NP_302151.1 15827888 910043 2021235..2021810 1 NC_002677.1 hypothetical protein 2021810 910043 ML1677 Mycobacterium leprae TN hypothetical protein NP_302151.1 2021235 D 272631 CDS NP_302152.1 15827889 910044 complement(2021819..2022973) 1 NC_002677.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 2022973 ddl 910044 ddl Mycobacterium leprae TN D-alanyl-alanine synthetase A NP_302152.1 2021819 R 272631 CDS NP_302153.1 15827890 910045 complement(2023085..2024140) 1 NC_002677.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2024140 gpsA 910045 gpsA Mycobacterium leprae TN NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_302153.1 2023085 R 272631 CDS NP_302154.1 15827891 910046 2024681..2025331 1 NC_002677.1 hypothetical protein 2025331 910046 ML1680 Mycobacterium leprae TN hypothetical protein NP_302154.1 2024681 D 272631 CDS NP_302155.1 15827892 910048 2025415..2027634 1 NC_002677.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2027634 910048 ML1681 Mycobacterium leprae TN polyphosphate kinase NP_302155.1 2025415 D 272631 CDS NP_302156.1 15827893 910049 2027713..2028648 1 NC_002677.1 hypothetical protein 2028648 910049 ML1682 Mycobacterium leprae TN hypothetical protein NP_302156.1 2027713 D 272631 CDS NP_302157.1 15827894 910050 complement(2028717..2029319) 1 NC_002677.1 histone-like protein 2029319 910050 ML1683 Mycobacterium leprae TN histone-like protein NP_302157.1 2028717 R 272631 CDS NP_302158.1 15827895 910051 complement(2029533..2030129) 1 NC_002677.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 2030129 leuD 910051 leuD Mycobacterium leprae TN isopropylmalate isomerase small subunit NP_302158.1 2029533 R 272631 CDS NP_302159.1 15827896 910053 complement(2030172..2031629) 1 NC_002677.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 2031629 leuC 910053 leuC Mycobacterium leprae TN isopropylmalate isomerase large subunit NP_302159.1 2030172 R 272631 CDS NP_302160.1 15827897 910058 complement(2033584..2035092) 1 NC_002677.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2035092 gltX 910058 gltX Mycobacterium leprae TN glutamyl-tRNA synthetase NP_302160.1 2033584 R 272631 CDS NP_302161.1 15827898 910059 complement(2035089..2035817) 1 NC_002677.1 hydrolase 2035817 910059 ML1689 Mycobacterium leprae TN hydrolase NP_302161.1 2035089 R 272631 CDS NP_302162.1 15827899 910061 complement(2037155..2038165) 1 NC_002677.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 2038165 leuB 910061 leuB Mycobacterium leprae TN 3-isopropylmalate dehydrogenase NP_302162.1 2037155 R 272631 CDS NP_302163.1 15827900 910062 complement(2038215..2039801) 1 NC_002677.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2039801 serA 910062 serA Mycobacterium leprae TN D-3-phosphoglycerate dehydrogenase NP_302163.1 2038215 R 272631 CDS NP_302164.1 15827901 910812 complement(2042720..2043721) 1 NC_002677.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2043721 ilvC 910812 ilvC Mycobacterium leprae TN ketol-acid reductoisomerase NP_302164.1 2042720 R 272631 CDS NP_302165.1 15827902 910799 complement(2043774..2044283) 1 NC_002677.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 2044283 ilvH 910799 ilvH Mycobacterium leprae TN acetolactate synthase 3 regulatory subunit NP_302165.1 2043774 R 272631 CDS NP_302166.1 15827903 910798 complement(2044335..2046212) 1 NC_002677.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 2046212 ilvB 910798 ilvB Mycobacterium leprae TN acetolactate synthase 1 catalytic subunit NP_302166.1 2044335 R 272631 CDS NP_302167.1 15827904 910796 complement(2046984..2047817) 1 NC_002677.1 hypothetical protein 2047817 910796 ML1698 Mycobacterium leprae TN hypothetical protein NP_302167.1 2046984 R 272631 CDS NP_302168.1 15827905 910795 2048060..2049178 1 NC_002677.1 lipoprotein 2049178 910795 ML1699 Mycobacterium leprae TN lipoprotein NP_302168.1 2048060 D 272631 CDS NP_302169.1 15827906 910794 complement(2050120..2051649) 1 NC_002677.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 2051649 gatB 910794 gatB Mycobacterium leprae TN aspartyl/glutamyl-tRNA amidotransferase subunit B NP_302169.1 2050120 R 272631 CDS NP_302170.1 15827907 910793 complement(2051998..2053029) 1 NC_002677.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 2053029 pfkA 910793 pfkA Mycobacterium leprae TN 6-phosphofructokinase NP_302170.1 2051998 R 272631 CDS NP_302171.1 15827908 910792 complement(2053117..2054610) 1 NC_002677.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 2054610 gatA 910792 gatA Mycobacterium leprae TN aspartyl/glutamyl-tRNA amidotransferase subunit A NP_302171.1 2053117 R 272631 CDS NP_302172.1 15827909 910791 complement(2054607..2054906) 1 NC_002677.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 2054906 gatC 910791 gatC Mycobacterium leprae TN aspartyl/glutamyl-tRNA amidotransferase subunit C NP_302172.1 2054607 R 272631 CDS NP_302173.1 15827910 910790 2055043..2055741 1 NC_002677.1 hypothetical protein 2055741 910790 ML1704 Mycobacterium leprae TN hypothetical protein NP_302173.1 2055043 D 272631 CDS NP_302174.1 15827911 910789 complement(2055744..2057828) 1 NC_002677.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2057828 ligA 910789 ligA Mycobacterium leprae TN NAD-dependent DNA ligase LigA NP_302174.1 2055744 R 272631 CDS NP_302175.1 15827912 910788 complement(2057887..2058900) 1 NC_002677.1 hypothetical protein 2058900 910788 ML1706 Mycobacterium leprae TN hypothetical protein NP_302175.1 2057887 R 272631 CDS NP_302176.1 15827913 910787 complement(2059816..2060892) 1 NC_002677.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2060892 mnmA 910787 mnmA Mycobacterium leprae TN tRNA-specific 2-thiouridylase MnmA NP_302176.1 2059816 R 272631 CDS NP_302177.1 15827914 910786 complement(2060889..2062121) 1 NC_002677.1 aminotransferase 2062121 910786 ML1708 Mycobacterium leprae TN aminotransferase NP_302177.1 2060889 R 272631 CDS NP_302178.1 15827915 910783 complement(2064075..2065031) 1 NC_002677.1 electron transfer flavoprotein [alpha] subunit 2065031 eftA 910783 eftA Mycobacterium leprae TN electron transfer flavoprotein [alpha] subunit NP_302178.1 2064075 R 272631 CDS NP_302179.1 15827916 910782 complement(2065080..2065880) 1 NC_002677.1 electron transfer flavoprotein [beta] subunit 2065880 eftB 910782 eftB Mycobacterium leprae TN electron transfer flavoprotein [beta] subunit NP_302179.1 2065080 R 272631 CDS NP_302180.1 15827917 910781 2066108..2066950 1 NC_002677.1 hypothetical protein 2066950 910781 ML1713 Mycobacterium leprae TN hypothetical protein NP_302180.1 2066108 D 272631 CDS NP_302181.1 15827918 910780 2066947..2068515 1 NC_002677.1 hypothetical protein 2068515 910780 ML1714 Mycobacterium leprae TN hypothetical protein NP_302181.1 2066947 D 272631 CDS NP_302182.1 15827919 910779 2068541..2069857 1 NC_002677.1 transferase 2069857 910779 ML1715 Mycobacterium leprae TN transferase NP_302182.1 2068541 D 272631 CDS NP_302183.1 15827920 910777 complement(2071353..2071646) 1 NC_002677.1 hypothetical protein 2071646 910777 ML1717 Mycobacterium leprae TN hypothetical protein NP_302183.1 2071353 R 272631 CDS NP_302184.1 15827921 910775 complement(2074924..2075661) 1 NC_002677.1 The C-terminus of this protein is; hypothetical protein 2075661 910775 ML1719 Mycobacterium leprae TN hypothetical protein NP_302184.1 2074924 R 272631 CDS NP_302185.1 15827922 910774 2076101..2077195 1 NC_002677.1 hypothetical protein 2077195 910774 ML1720 Mycobacterium leprae TN hypothetical protein NP_302185.1 2076101 D 272631 CDS NP_302186.1 15827923 910770 complement(2079775..2080758) 1 NC_002677.1 hypothetical protein 2080758 910770 ML1723 Mycobacterium leprae TN hypothetical protein NP_302186.1 2079775 R 272631 CDS NP_302187.1 15827924 910769 complement(2080791..2081549) 1 NC_002677.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2081549 910769 ML1724 Mycobacterium leprae TN enoyl-CoA hydratase NP_302187.1 2080791 R 272631 CDS NP_302188.1 15827925 910767 complement(2082421..2083338) 1 NC_002677.1 ABC transporter protein, ATP-binding component 2083338 910767 ML1726 Mycobacterium leprae TN ABC transporter protein, ATP-binding component NP_302188.1 2082421 R 272631 CDS NP_302189.1 15827926 910766 complement(2083348..2084583) 1 NC_002677.1 phosphoserine phosphatase 2084583 910766 ML1727 Mycobacterium leprae TN phosphoserine phosphatase NP_302189.1 2083348 R 272631 CDS NP_302190.1 15827927 910765 complement(2084623..2086347) 1 NC_002677.1 cytochrome C oxidase, polypeptide I 2086347 910765 ML1728 Mycobacterium leprae TN cytochrome C oxidase, polypeptide I NP_302190.1 2084623 R 272631 CDS NP_302191.1 15827928 910764 2086562..2087656 1 NC_002677.1 FeIII-dicitrate transporter lipoprotein 2087656 fecB 910764 fecB Mycobacterium leprae TN FeIII-dicitrate transporter lipoprotein NP_302191.1 2086562 D 272631 CDS NP_302192.1 15827929 910763 2087916..2089004 1 NC_002677.1 alcohol dehydrogenase 2089004 adhA 910763 adhA Mycobacterium leprae TN alcohol dehydrogenase NP_302192.1 2087916 D 272631 CDS NP_302193.1 15827930 910762 complement(2090613..2091590) 1 NC_002677.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2091590 nrdF 910762 nrdF Mycobacterium leprae TN ribonucleotide-diphosphate reductase subunit beta NP_302193.1 2090613 R 272631 CDS NP_302194.1 15827931 910760 complement(2093450..2094277) 1 NC_002677.1 TetR family transcriptional regulator 2094277 910760 ML1733 Mycobacterium leprae TN TetR family transcriptional regulator NP_302194.1 2093450 R 272631 CDS NP_302195.1 15827932 910759 complement(2094324..2096405) 1 NC_002677.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2096405 nrdE 910759 nrdE Mycobacterium leprae TN ribonucleotide-diphosphate reductase subunit alpha NP_302195.1 2094324 R 272631 CDS NP_302196.1 15827933 910758 complement(2096490..2096906) 1 NC_002677.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2096906 nrdI 910758 nrdI Mycobacterium leprae TN ribonucleotide reductase stimulatory protein NP_302196.1 2096490 R 272631 CDS NP_302197.1 15827934 910757 complement(2096935..2097177) 1 NC_002677.1 glutaredoxin electron transport component of NrdEF 2097177 nrdH 910757 nrdH Mycobacterium leprae TN glutaredoxin electron transport component of NrdEF NP_302197.1 2096935 R 272631 CDS NP_302198.1 15827935 910753 complement(2099981..2100919) 1 NC_002677.1 short chain dehydrogenase 2100919 910753 ML1740 Mycobacterium leprae TN short chain dehydrogenase NP_302198.1 2099981 R 272631 CDS NP_302199.1 15827936 910743 complement(2115121..2116992) 1 NC_002677.1 The C-terminus of this protein is; hypothetical protein 2116992 910743 ML1750 Mycobacterium leprae TN hypothetical protein NP_302199.1 2115121 R 272631 CDS NP_302200.1 15827937 910742 complement(2117010..2119175) 1 NC_002677.1 hypothetical protein 2119175 910742 ML1751 Mycobacterium leprae TN hypothetical protein NP_302200.1 2117010 R 272631 CDS NP_302201.1 15827938 910741 complement(2121319..2122227) 1 NC_002677.1 hypothetical protein 2122227 910741 ML1752 Mycobacterium leprae TN hypothetical protein NP_302201.1 2121319 R 272631 CDS NP_302202.1 15827939 910740 complement(2123768..2127088) 1 NC_002677.1 transcriptional regulator 2127088 910740 ML1753 Mycobacterium leprae TN transcriptional regulator NP_302202.1 2123768 R 272631 CDS NP_302203.1 15827940 910738 complement(2129657..2131033) 1 NC_002677.1 L-serine dehydratase 2131033 sdaA 910738 sdaA Mycobacterium leprae TN L-serine dehydratase NP_302203.1 2129657 R 272631 CDS NP_302204.1 15827941 910737 2131291..2131614 1 NC_002677.1 multidrug resistance protein 2131614 910737 ML1756 Mycobacterium leprae TN multidrug resistance protein NP_302204.1 2131291 D 272631 CDS NP_302205.1 15827942 910730 complement(2136027..2136371) 1 NC_002677.1 hypothetical protein 2136371 910730 ML1761 Mycobacterium leprae TN hypothetical protein NP_302205.1 2136027 R 272631 CDS NP_302206.1 15827943 910728 2138763..2138978 1 NC_002677.1 hypothetical protein 2138978 910728 ML1763 Mycobacterium leprae TN hypothetical protein NP_302206.1 2138763 D 272631 CDS NP_302207.1 15827944 910723 2143276..2144262 1 NC_002677.1 sugar transport integral membrane protein 2144262 uspA 910723 uspA Mycobacterium leprae TN sugar transport integral membrane protein NP_302207.1 2143276 D 272631 CDS NP_302208.1 15827945 910722 2144249..2145073 1 NC_002677.1 sugar transport integral membrane protein 2145073 uspE 910722 uspE Mycobacterium leprae TN sugar transport integral membrane protein NP_302208.1 2144249 D 272631 CDS NP_302209.1 15827946 910721 2145165..2146505 1 NC_002677.1 sugar transport periplasmic binding protein 2146505 uspC 910721 uspC Mycobacterium leprae TN sugar transport periplasmic binding protein NP_302209.1 2145165 D 272631 CDS NP_302210.1 15827947 910710 complement(2157673..2158185) 1 NC_002677.1 hypothetical protein 2158185 910710 ML1781 Mycobacterium leprae TN hypothetical protein NP_302210.1 2157673 R 272631 CDS NP_302211.1 15827948 910709 complement(2158324..2159145) 1 NC_002677.1 hypothetical protein 2159145 910709 ML1782 Mycobacterium leprae TN hypothetical protein NP_302211.1 2158324 R 272631 CDS NP_302212.1 15827949 910708 complement(2159145..2160113) 1 NC_002677.1 transcriptional regulator 2160113 910708 ML1783 Mycobacterium leprae TN transcriptional regulator NP_302212.1 2159145 R 272631 CDS NP_302213.1 15827950 910707 2160275..2161360 1 NC_002677.1 alcohol dehydrogenase 2161360 adhE2 910707 adhE2 Mycobacterium leprae TN alcohol dehydrogenase NP_302213.1 2160275 D 272631 CDS NP_302214.1 15827951 910703 complement(2163355..2163819) 1 NC_002677.1 hypothetical protein 2163819 910703 ML1788 Mycobacterium leprae TN hypothetical protein NP_302214.1 2163355 R 272631 CDS NP_302215.1 15827952 910700 complement(2165620..2166063) 1 NC_002677.1 hypothetical protein 2166063 910700 ML1791 Mycobacterium leprae TN hypothetical protein NP_302215.1 2165620 R 272631 CDS NP_302216.1 15827953 910698 2169013..2169318 1 NC_002677.1 hypothetical protein 2169318 910698 ML1793 Mycobacterium leprae TN hypothetical protein NP_302216.1 2169013 D 272631 CDS NP_302217.1 15827954 910697 2171512..2172720 1 NC_002677.1 aminotransferase 2172720 910697 ML1794 Mycobacterium leprae TN aminotransferase NP_302217.1 2171512 D 272631 CDS NP_302218.1 15827955 910696 2174297..2174743 1 NC_002677.1 hypothetical protein 2174743 hsp18 910696 hsp18 Mycobacterium leprae TN hypothetical protein NP_302218.1 2174297 D 272631 CDS NP_302219.1 15827956 910695 2175302..2175715 1 NC_002677.1 hypothetical protein 2175715 910695 ML1796 Mycobacterium leprae TN hypothetical protein NP_302219.1 2175302 D 272631 CDS NP_302220.1 15827957 910693 complement(2176919..2177902) 1 NC_002677.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2177902 910693 ML1798 Mycobacterium leprae TN arginine/ornithine transport system ATPase NP_302220.1 2176919 R 272631 CDS NP_302221.1 15827958 910692 complement(2177903..2180179) 1 NC_002677.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2180179 mutB 910692 mutB Mycobacterium leprae TN methylmalonyl-CoA mutase NP_302221.1 2177903 R 272631 CDS NP_302222.1 15827959 910691 complement(2180185..2182095) 1 NC_002677.1 methylmalonyl-CoA mutase, [beta] subunit 2182095 mutA 910691 mutA Mycobacterium leprae TN methylmalonyl-CoA mutase, [beta] subunit NP_302222.1 2180185 R 272631 CDS NP_302223.1 15827960 910689 complement(2183195..2184319) 1 NC_002677.1 hypothetical protein 2184319 910689 ML1802 Mycobacterium leprae TN hypothetical protein NP_302223.1 2183195 R 272631 CDS NP_302224.1 15827961 910688 complement(2184356..2184787) 1 NC_002677.1 hypothetical protein 2184787 910688 ML1803 Mycobacterium leprae TN hypothetical protein NP_302224.1 2184356 R 272631 CDS NP_302225.1 15827962 910687 2184845..2185741 1 NC_002677.1 hypothetical protein 2185741 910687 ML1804 Mycobacterium leprae TN hypothetical protein NP_302225.1 2184845 D 272631 CDS NP_302226.1 15827963 910686 complement(2185778..2186788) 1 NC_002677.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 2186788 hemH 910686 hemH Mycobacterium leprae TN ferrochelatase NP_302226.1 2185778 R 272631 CDS NP_302227.1 15827964 910685 complement(2186795..2187604) 1 NC_002677.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 2187604 inhA 910685 inhA Mycobacterium leprae TN enoyl-ACP reductase NP_302227.1 2186795 R 272631 CDS NP_302228.1 15827965 910684 complement(2187634..2188395) 1 NC_002677.1 3-oxoacyl-ACP reductase 2188395 fabG1 910684 fabG1 Mycobacterium leprae TN 3-oxoacyl-ACP reductase NP_302228.1 2187634 R 272631 CDS NP_302229.1 15827966 910683 complement(2188468..2189475) 1 NC_002677.1 hypothetical protein 2189475 910683 ML1808 Mycobacterium leprae TN hypothetical protein NP_302229.1 2188468 R 272631 CDS NP_302230.1 15827967 910682 complement(2189519..2190481) 1 NC_002677.1 hypothetical protein 2190481 910682 ML1809 Mycobacterium leprae TN hypothetical protein NP_302230.1 2189519 R 272631 CDS NP_302231.1 15827968 910681 complement(2190478..2191611) 1 NC_002677.1 MoxR-like protein 2191611 moxR 910681 moxR Mycobacterium leprae TN MoxR-like protein NP_302231.1 2190478 R 272631 CDS NP_302232.1 15827969 910680 complement(2191846..2192571) 1 NC_002677.1 hypothetical protein 2192571 910680 ML1811 Mycobacterium leprae TN hypothetical protein NP_302232.1 2191846 R 272631 CDS NP_302233.1 15827970 910679 complement(2192598..2194037) 1 NC_002677.1 hypothetical protein 2194037 910679 ML1812 Mycobacterium leprae TN hypothetical protein NP_302233.1 2192598 R 272631 CDS NP_302234.1 15827971 910678 complement(2194277..2194849) 1 NC_002677.1 hypothetical protein 2194849 910678 ML1813 Mycobacterium leprae TN hypothetical protein NP_302234.1 2194277 R 272631 CDS NP_302235.1 15827972 910677 2195132..2197966 1 NC_002677.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 2197966 acn 910677 acn Mycobacterium leprae TN aconitate hydratase NP_302235.1 2195132 D 272631 CDS NP_302236.1 15827973 910675 complement(2198955..2200592) 1 NC_002677.1 ABC transporter ATP-binding protein 2200592 910675 ML1816 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_302236.1 2198955 R 272631 CDS NP_302237.1 15827974 910673 complement(2201521..2201913) 1 NC_002677.1 thioredoxin 2201913 trxB 910673 trxB Mycobacterium leprae TN thioredoxin NP_302237.1 2201521 R 272631 CDS NP_302238.1 15827975 910670 complement(2204726..2205079) 1 NC_002677.1 hypothetical protein 2205079 910670 ML1821 Mycobacterium leprae TN hypothetical protein NP_302238.1 2204726 R 272631 CDS NP_302239.1 15827976 910663 complement(2212448..2214166) 1 NC_002677.1 PPE family protein 2214166 PPE 910663 PPE Mycobacterium leprae TN PPE family protein NP_302239.1 2212448 R 272631 CDS NP_302240.1 15827977 910661 2214813..2215190 1 NC_002677.1 hypothetical protein 2215190 910661 ML1829 Mycobacterium leprae TN hypothetical protein NP_302240.1 2214813 D 272631 CDS NP_302241.1 15827978 910659 complement(2219402..2220202) 1 NC_002677.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 2220202 mapA 910659 mapA Mycobacterium leprae TN methionine aminopeptidase NP_302241.1 2219402 R 272631 CDS NP_302242.1 15827979 910658 complement(2220214..2220759) 1 NC_002677.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 2220759 adk 910658 adk Mycobacterium leprae TN adenylate kinase NP_302242.1 2220214 R 272631 CDS NP_302243.1 15827980 910657 complement(2220756..2222072) 1 NC_002677.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 2222072 secY 910657 secY Mycobacterium leprae TN preprotein translocase subunit SecY NP_302243.1 2220756 R 272631 CDS NP_302244.1 15827981 910655 complement(2223216..2223899) 1 NC_002677.1 hypothetical protein 2223899 910655 ML1835 Mycobacterium leprae TN hypothetical protein NP_302244.1 2223216 R 272631 CDS NP_302245.1 15827982 910651 complement(2226936..2228744) 1 NC_002677.1 endopeptidase IV 2228744 sppA 910651 sppA Mycobacterium leprae TN endopeptidase IV NP_302245.1 2226936 R 272631 CDS NP_302246.1 15827983 910650 complement(2228980..2229420) 1 NC_002677.1 late assembly protein; 50S ribosomal protein L15 2229420 rplO 910650 rplO Mycobacterium leprae TN 50S ribosomal protein L15 NP_302246.1 2228980 R 272631 CDS NP_302247.1 15827984 910649 complement(2229421..2229636) 1 NC_002677.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 2229636 rpmD 910649 rpmD Mycobacterium leprae TN 50S ribosomal protein L30 NP_302247.1 2229421 R 272631 CDS NP_302248.1 15827985 910648 complement(2229639..2230292) 1 NC_002677.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 2230292 rpsE 910648 rpsE Mycobacterium leprae TN 30S ribosomal protein S5 NP_302248.1 2229639 R 272631 CDS NP_302249.1 15827986 910647 complement(2230321..2230686) 1 NC_002677.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 2230686 rplR 910647 rplR Mycobacterium leprae TN 50S ribosomal protein L18 NP_302249.1 2230321 R 272631 CDS NP_302250.1 15827987 910646 complement(2230692..2231231) 1 NC_002677.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 2231231 rplF 910646 rplF Mycobacterium leprae TN 50S ribosomal protein L6 NP_302250.1 2230692 R 272631 CDS NP_302251.1 15827988 910645 complement(2231257..2231655) 1 NC_002677.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 2231655 rpsH 910645 rpsH Mycobacterium leprae TN 30S ribosomal protein S8 NP_302251.1 2231257 R 272631 CDS NP_302252.1 15827989 910644 complement(2231738..2231923) 1 NC_002677.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 2231923 rpsN 910644 rpsN Mycobacterium leprae TN 30S ribosomal protein S14 NP_302252.1 2231738 R 272631 CDS NP_302253.1 15827990 910643 complement(2231929..2232492) 1 NC_002677.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 2232492 rplE 910643 rplE Mycobacterium leprae TN 50S ribosomal protein L5 NP_302253.1 2231929 R 272631 CDS NP_302254.1 15827991 910642 complement(2232493..2232810) 1 NC_002677.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 2232810 rplX 910642 rplX Mycobacterium leprae TN 50S ribosomal protein L24 NP_302254.1 2232493 R 272631 CDS NP_302255.1 15827992 910641 complement(2232811..2233152) 1 NC_002677.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 2233152 rplN 910641 rplN Mycobacterium leprae TN 50S ribosomal protein L14 NP_302255.1 2232811 R 272631 CDS NP_302256.1 15827993 910636 complement(2238349..2238732) 1 NC_002677.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 2238732 rpsQ 910636 rpsQ Mycobacterium leprae TN 30S ribosomal protein S17 NP_302256.1 2238349 R 272631 CDS NP_302257.1 15827994 910635 complement(2238729..2238974) 1 NC_002677.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 2238974 rpmC 910635 rpmC Mycobacterium leprae TN 50S ribosomal protein L29 NP_302257.1 2238729 R 272631 CDS NP_302258.1 15827995 910634 complement(2238971..2239387) 1 NC_002677.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 2239387 rplP 910634 rplP Mycobacterium leprae TN 50S ribosomal protein L16 NP_302258.1 2238971 R 272631 CDS NP_302259.1 15827996 910633 complement(2239391..2240236) 1 NC_002677.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 2240236 rpsC 910633 rpsC Mycobacterium leprae TN 30S ribosomal protein S3 NP_302259.1 2239391 R 272631 CDS NP_302260.1 15827997 910632 complement(2240236..2240763) 1 NC_002677.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 2240763 rplV 910632 rplV Mycobacterium leprae TN 50S ribosomal protein L22 NP_302260.1 2240236 R 272631 CDS NP_302261.1 15827998 910631 complement(2240760..2241041) 1 NC_002677.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 2241041 rpsS 910631 rpsS Mycobacterium leprae TN 30S ribosomal protein S19 NP_302261.1 2240760 R 272631 CDS NP_302262.1 15827999 910630 complement(2241065..2241907) 1 NC_002677.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 2241907 rplB 910630 rplB Mycobacterium leprae TN 50S ribosomal protein L2 NP_302262.1 2241065 R 272631 CDS NP_302263.1 15828000 910629 complement(2241937..2242239) 1 NC_002677.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 2242239 rplW 910629 rplW Mycobacterium leprae TN 50S ribosomal protein L23 NP_302263.1 2241937 R 272631 CDS NP_302264.1 15828001 910628 complement(2242239..2242931) 1 NC_002677.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 2242931 rplD 910628 rplD Mycobacterium leprae TN 50S ribosomal protein L4 NP_302264.1 2242239 R 272631 CDS NP_302265.1 15828002 910627 complement(2242931..2243587) 1 NC_002677.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 2243587 rplC 910627 rplC Mycobacterium leprae TN 50S ribosomal protein L3 NP_302265.1 2242931 R 272631 CDS NP_302266.1 15828003 910626 complement(2243600..2243905) 1 NC_002677.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 2243905 rpsJ 910626 rpsJ Mycobacterium leprae TN 30S ribosomal protein S10 NP_302266.1 2243600 R 272631 CDS NP_302267.1 15828004 910613 complement(2255790..2256980) 1 NC_002677.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 2256980 tuf 910613 tuf Mycobacterium leprae TN elongation factor Tu NP_302267.1 2255790 R 272631 CDS NP_302268.1 15828005 910612 complement(2257089..2259194) 1 NC_002677.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 2259194 fusA 910612 fusA Mycobacterium leprae TN elongation factor G NP_302268.1 2257089 R 272631 CDS NP_302269.1 15828006 910611 complement(2259288..2259758) 1 NC_002677.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 2259758 rpsG 910611 rpsG Mycobacterium leprae TN 30S ribosomal protein S7 NP_302269.1 2259288 R 272631 CDS NP_302270.1 15828007 910610 complement(2259758..2260132) 1 NC_002677.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 2260132 rpsL 910610 rpsL Mycobacterium leprae TN 30S ribosomal protein S12 NP_302270.1 2259758 R 272631 CDS NP_302271.1 15828008 910601 complement(2268187..2268945) 1 NC_002677.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2268945 910601 ML1889 Mycobacterium leprae TN endonuclease IV NP_302271.1 2268187 R 272631 CDS NP_302272.1 15828009 910600 complement(2269270..2273220) 1 NC_002677.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 2273220 rpoC 910600 rpoC Mycobacterium leprae TN DNA-directed RNA polymerase subunit beta' NP_302272.1 2269270 R 272631 CDS NP_302273.1 15828010 910599 complement(2273269..2276805) 1 NC_002677.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 2276805 rpoB 910599 rpoB Mycobacterium leprae TN DNA-directed RNA polymerase subunit beta NP_302273.1 2273269 R 272631 CDS NP_302274.1 15828011 910598 complement(2277260..2278276) 1 NC_002677.1 ABC transporter ATP-binding protein 2278276 910598 ML1892 Mycobacterium leprae TN ABC transporter ATP-binding protein NP_302274.1 2277260 R 272631 CDS NP_302275.1 15828012 910595 complement(2280435..2280827) 1 NC_002677.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 2280827 rplL 910595 rplL Mycobacterium leprae TN 50S ribosomal protein L7/L12 NP_302275.1 2280435 R 272631 CDS NP_302276.1 15828013 910594 complement(2280863..2281396) 1 NC_002677.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 2281396 rplJ 910594 rplJ Mycobacterium leprae TN 50S ribosomal protein L10 NP_302276.1 2280863 R 272631 CDS NP_302277.1 15828014 910592 2282288..2283634 1 NC_002677.1 hypothetical protein 2283634 910592 ML1898 Mycobacterium leprae TN hypothetical protein NP_302277.1 2282288 D 272631 CDS NP_302278.1 15828015 910591 2283634..2284548 1 NC_002677.1 hydrolase 2284548 lipG 910591 lipG Mycobacterium leprae TN hydrolase NP_302278.1 2283634 D 272631 CDS NP_302279.1 15828016 910590 2284606..2285466 1 NC_002677.1 methyl mycolic acid synthase 1 2285466 mmaA1 910590 mmaA1 Mycobacterium leprae TN methyl mycolic acid synthase 1 NP_302279.1 2284606 D 272631 CDS NP_302280.1 15828017 910587 2287631..2288527 1 NC_002677.1 methyl mycolic acid synthase 4 2288527 mmaA4 910587 mmaA4 Mycobacterium leprae TN methyl mycolic acid synthase 4 NP_302280.1 2287631 D 272631 CDS NP_302281.1 15828018 910586 complement(2290309..2291016) 1 NC_002677.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 2291016 rplA 910586 rplA Mycobacterium leprae TN 50S ribosomal protein L1 NP_302281.1 2290309 R 272631 CDS NP_302282.1 15828019 910585 complement(2291148..2291576) 1 NC_002677.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 2291576 rplK 910585 rplK Mycobacterium leprae TN 50S ribosomal protein L11 NP_302282.1 2291148 R 272631 CDS NP_302283.1 15828020 910584 complement(2291604..2292290) 1 NC_002677.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 2292290 nusG 910584 nusG Mycobacterium leprae TN transcription antitermination protein NusG NP_302283.1 2291604 R 272631 CDS NP_302284.1 15828021 910583 complement(2292368..2292808) 1 NC_002677.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 2292808 secE 910583 secE Mycobacterium leprae TN preprotein translocase subunit SecE NP_302284.1 2292368 R 272631 CDS NP_302285.1 15828022 910581 complement(2293144..2293644) 1 NC_002677.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 2293644 910581 ML1908 Mycobacterium leprae TN (3R)-hydroxyacyl-ACP dehydratase subunit HadC NP_302285.1 2293144 R 272631 CDS NP_302286.1 15828023 910580 complement(2293648..2294076) 1 NC_002677.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 2294076 910580 ML1909 Mycobacterium leprae TN (3R)-hydroxyacyl-ACP dehydratase subunit HadB NP_302286.1 2293648 R 272631 CDS NP_302287.1 15828024 910579 complement(2294063..2294542) 1 NC_002677.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 2294542 910579 ML1910 Mycobacterium leprae TN (3R)-hydroxyacyl-ACP dehydratase subunit HadA NP_302287.1 2294063 R 272631 CDS NP_302288.1 15828025 910578 complement(2294589..2294756) 1 NC_002677.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 2294756 rpmG 910578 rpmG Mycobacterium leprae TN 50S ribosomal protein L33 NP_302288.1 2294589 R 272631 CDS NP_302289.1 15828026 910575 complement(2295156..2295371) 1 NC_002677.1 hypothetical protein 2295371 910575 ML1911A Mycobacterium leprae TN hypothetical protein NP_302289.1 2295156 R 272631 CDS NP_302290.1 15828027 910574 2295524..2296240 1 NC_002677.1 glyoxylase 2296240 910574 ML1912 Mycobacterium leprae TN glyoxylase NP_302290.1 2295524 D 272631 CDS NP_302291.1 15828028 910345 2298471..2298815 1 NC_002677.1 hypothetical protein 2298815 910345 ML1915 Mycobacterium leprae TN hypothetical protein NP_302291.1 2298471 D 272631 CDS NP_302292.1 15828029 910252 complement(2301835..2302626) 1 NC_002677.1 hypothetical protein 2302626 910252 ML1918 Mycobacterium leprae TN hypothetical protein NP_302292.1 2301835 R 272631 CDS NP_302293.1 15828030 910236 complement(2302765..2303406) 1 NC_002677.1 carbonic anhydrase 2303406 910236 ML1919 Mycobacterium leprae TN carbonic anhydrase NP_302293.1 2302765 R 272631 CDS NP_302294.1 15828031 910168 2303405..2304298 1 NC_002677.1 DNA glycosylase 2304298 mutY 910168 mutY Mycobacterium leprae TN DNA glycosylase NP_302294.1 2303405 D 272631 CDS NP_302295.1 15828032 910125 complement(2304307..2305077) 1 NC_002677.1 hypothetical protein 2305077 910125 ML1921 Mycobacterium leprae TN hypothetical protein NP_302295.1 2304307 R 272631 CDS NP_302296.1 15828033 910111 2305203..2305520 1 NC_002677.1 hypothetical protein 2305520 910111 ML1922 Mycobacterium leprae TN hypothetical protein NP_302296.1 2305203 D 272631 CDS NP_302297.1 15828034 910110 2305495..2306859 1 NC_002677.1 hypothetical protein 2306859 lpqF 910110 lpqF Mycobacterium leprae TN hypothetical protein NP_302297.1 2305495 D 272631 CDS NP_302298.1 15828035 910108 complement(2310771..2311493) 1 NC_002677.1 superoxide dismutase (Cu-Zn) 2311493 sodC 910108 sodC Mycobacterium leprae TN superoxide dismutase (Cu-Zn) NP_302298.1 2310771 R 272631 CDS NP_302299.1 15828036 910107 complement(2311558..2312061) 1 NC_002677.1 tuberculin related peptide 2312061 910107 ML1926 Mycobacterium leprae TN tuberculin related peptide NP_302299.1 2311558 R 272631 CDS NP_302300.1 15828037 910105 complement(2312092..2312400) 1 NC_002677.1 hypothetical protein 2312400 910105 ML1927 Mycobacterium leprae TN hypothetical protein NP_302300.1 2312092 R 272631 CDS NP_302301.1 15828038 910104 complement(2312431..2312568) 1 NC_002677.1 hypothetical protein 2312568 910104 ML1928 Mycobacterium leprae TN hypothetical protein NP_302301.1 2312431 R 272631 CDS NP_302302.1 15828039 910103 2312615..2313208 1 NC_002677.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 2313208 def 910103 def Mycobacterium leprae TN peptide deformylase NP_302302.1 2312615 D 272631 CDS NP_302303.1 15828040 910100 2314821..2315234 1 NC_002677.1 hypothetical protein 2315234 910100 ML1932 Mycobacterium leprae TN hypothetical protein NP_302303.1 2314821 D 272631 CDS NP_302304.1 15828041 910095 complement(2322199..2323269) 1 NC_002677.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 2323269 910095 ML1936 Mycobacterium leprae TN GTP-dependent nucleic acid-binding protein EngD NP_302304.1 2322199 R 272631 CDS NP_302305.1 15828042 910094 2323320..2324552 1 NC_002677.1 hypothetical protein 2324552 910094 ML1937 Mycobacterium leprae TN hypothetical protein NP_302305.1 2323320 D 272631 CDS NP_302306.1 15828043 910093 complement(2324563..2325570) 1 NC_002677.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2325570 ispH 910093 ispH Mycobacterium leprae TN 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_302306.1 2324563 R 272631 CDS NP_302307.1 15828044 910091 2325739..2326356 1 NC_002677.1 hypothetical protein 2326356 910091 ML1939 Mycobacterium leprae TN hypothetical protein NP_302307.1 2325739 D 272631 CDS NP_302308.1 15828045 910082 2326353..2327639 1 NC_002677.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2327639 xseA 910082 xseA Mycobacterium leprae TN exodeoxyribonuclease VII large subunit NP_302308.1 2326353 D 272631 CDS NP_302309.1 15828046 910018 2327629..2327892 1 NC_002677.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 2327892 xseB 910018 xseB Mycobacterium leprae TN exodeoxyribonuclease VII small subunit NP_302309.1 2327629 D 272631 CDS NP_302310.1 15828047 910016 2327943..2329073 1 NC_002677.1 cholesterol dehydrogenase 2329073 910016 ML1942 Mycobacterium leprae TN cholesterol dehydrogenase NP_302310.1 2327943 D 272631 CDS NP_302311.1 15828048 909852 complement(2331776..2332549) 1 NC_002677.1 hypothetical protein 2332549 909852 ML1945 Mycobacterium leprae TN hypothetical protein NP_302311.1 2331776 R 272631 CDS NP_302312.1 15828049 909793 2332629..2333615 1 NC_002677.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 2333615 glpX 909793 glpX Mycobacterium leprae TN fructose 1,6-bisphosphatase II NP_302312.1 2332629 D 272631 CDS NP_302313.2 161723266 909446 2333642..2335048 1 NC_002677.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 2335048 fumC 909446 fumC Mycobacterium leprae TN fumarate hydratase NP_302313.2 2333642 D 272631 CDS NP_302314.1 15828051 909442 complement(2336277..2336636) 1 NC_002677.1 hypothetical protein 2336636 909442 ML1949 Mycobacterium leprae TN hypothetical protein NP_302314.1 2336277 R 272631 CDS NP_302315.1 15828052 909441 complement(2336689..2337564) 1 NC_002677.1 carbohydrate degrading enzyme 2337564 909441 ML1950 Mycobacterium leprae TN carbohydrate degrading enzyme NP_302315.1 2336689 R 272631 CDS NP_302316.1 15828053 909438 complement(2337619..2338920) 1 NC_002677.1 PhoH-like protein 2338920 phoH2 909438 phoH2 Mycobacterium leprae TN PhoH-like protein NP_302316.1 2337619 R 272631 CDS NP_302317.1 15828054 909437 complement(2339270..2340097) 1 NC_002677.1 acyl-[ACP] desaturase 2340097 desA2 909437 desA2 Mycobacterium leprae TN acyl-[ACP] desaturase NP_302317.1 2339270 R 272631 CDS NP_302318.1 15828055 909436 complement(2340154..2341434) 1 NC_002677.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2341434 glyA 909436 glyA Mycobacterium leprae TN serine hydroxymethyltransferase NP_302318.1 2340154 R 272631 CDS NP_302319.1 15828056 909435 2341563..2342501 1 NC_002677.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 2342501 coaA 909435 coaA Mycobacterium leprae TN pantothenate kinase NP_302319.1 2341563 D 272631 CDS NP_302320.2 161723265 909431 complement(2343329..2344291) 1 NC_002677.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2344291 truA 909431 truA Mycobacterium leprae TN tRNA pseudouridine synthase A NP_302320.2 2343329 R 272631 CDS NP_302321.1 15828058 909428 complement(2344170..2344682) 1 NC_002677.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 2344682 rplQ 909428 rplQ Mycobacterium leprae TN 50S ribosomal protein L17 NP_302321.1 2344170 R 272631 CDS NP_302322.1 15828059 909427 complement(2344706..2345749) 1 NC_002677.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 2345749 rpoA 909427 rpoA Mycobacterium leprae TN DNA-directed RNA polymerase subunit alpha NP_302322.1 2344706 R 272631 CDS NP_302323.1 15828060 909424 complement(2345834..2346439) 1 NC_002677.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 2346439 rpsD 909424 rpsD Mycobacterium leprae TN 30S ribosomal protein S4 NP_302323.1 2345834 R 272631 CDS NP_302324.1 15828061 909287 complement(2346473..2346889) 1 NC_002677.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 2346889 rpsK 909287 rpsK Mycobacterium leprae TN 30S ribosomal protein S11 NP_302324.1 2346473 R 272631 CDS NP_302325.1 15828062 909225 complement(2346893..2347267) 1 NC_002677.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 2347267 rpsM 909225 rpsM Mycobacterium leprae TN 30S ribosomal protein S13 NP_302325.1 2346893 R 272631 CDS NP_302326.1 15828063 909164 complement(2347444..2347557) 1 NC_002677.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 2347557 rpmJ 909164 rpmJ Mycobacterium leprae TN 50S ribosomal protein L36 NP_302326.1 2347444 R 272631 CDS NP_302327.1 15828064 909145 complement(2347597..2347818) 1 NC_002677.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2347818 infA 909145 infA Mycobacterium leprae TN translation initiation factor IF-1 NP_302327.1 2347597 R 272631 CDS NP_302328.1 15828065 909140 2348333..2349334 1 NC_002677.1 dTDP-glucose 4,6-dehydratase 2349334 rmlB 909140 rmlB Mycobacterium leprae TN dTDP-glucose 4,6-dehydratase NP_302328.1 2348333 D 272631 CDS NP_302329.1 15828066 909135 2349336..2349944 1 NC_002677.1 dTDP-4-dehydrorhamnose 3,5-epimerase 2349944 rmlC 909135 rmlC Mycobacterium leprae TN dTDP-4-dehydrorhamnose 3,5-epimerase NP_302329.1 2349336 D 272631 CDS NP_302330.1 15828067 909134 2349989..2350474 1 NC_002677.1 lipoprotein 2350474 lpqH 909134 lpqH Mycobacterium leprae TN lipoprotein NP_302330.1 2349989 D 272631 CDS NP_302331.1 15828068 909122 complement(2356311..2356541) 1 NC_002677.1 hypothetical protein 2356541 909122 ML1972 Mycobacterium leprae TN hypothetical protein NP_302331.1 2356311 R 272631 CDS NP_302332.1 15828069 909118 2358452..2360170 1 NC_002677.1 permease 2360170 909118 ML1974 Mycobacterium leprae TN permease NP_302332.1 2358452 D 272631 CDS NP_302333.1 15828070 909115 complement(2361219..2361566) 1 NC_002677.1 hypothetical protein 2361566 909115 ML1976 Mycobacterium leprae TN hypothetical protein NP_302333.1 2361219 R 272631 CDS NP_302334.1 15828071 909111 complement(2363934..2364341) 1 NC_002677.1 hypothetical protein 2364341 909111 ML1979 Mycobacterium leprae TN hypothetical protein NP_302334.1 2363934 R 272631 CDS NP_302335.1 15828072 909108 2366597..2366905 1 NC_002677.1 hypothetical protein 2366905 909108 ML1982 Mycobacterium leprae TN hypothetical protein NP_302335.1 2366597 D 272631 CDS NP_302336.1 15828073 909107 2367418..2367885 1 NC_002677.1 hypothetical protein 2367885 909107 ML1983 Mycobacterium leprae TN hypothetical protein NP_302336.1 2367418 D 272631 CDS NP_302337.1 15828074 909102 complement(2369802..2372198) 1 NC_002677.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 2372198 aceA 909102 aceA Mycobacterium leprae TN isocitrate lyase NP_302337.1 2369802 R 272631 CDS NP_302338.1 15828075 909100 2373427..2375727 1 NC_002677.1 cation-transporting ATPase 2375727 ctpA 909100 ctpA Mycobacterium leprae TN cation-transporting ATPase NP_302338.1 2373427 D 272631 CDS NP_302339.1 15828076 909099 complement(2375705..2376418) 1 NC_002677.1 hypothetical protein 2376418 909099 ML1988 Mycobacterium leprae TN hypothetical protein NP_302339.1 2375705 R 272631 CDS NP_302340.1 15828077 909098 complement(2376735..2377085) 1 NC_002677.1 hypothetical protein 2377085 909098 ML1989 Mycobacterium leprae TN hypothetical protein NP_302340.1 2376735 R 272631 CDS NP_302341.1 15828078 909097 complement(2377165..2377407) 1 NC_002677.1 hypothetical protein 2377407 909097 ML1990 Mycobacterium leprae TN hypothetical protein NP_302341.1 2377165 R 272631 CDS NP_302342.1 15828079 909096 2378494..2379900 1 NC_002677.1 PPE family protein 2379900 PPE 909096 PPE Mycobacterium leprae TN PPE family protein NP_302342.1 2378494 D 272631 CDS NP_302343.1 15828080 909095 2380049..2380918 1 NC_002677.1 oxidoreductase 2380918 909095 ML1992 Mycobacterium leprae TN oxidoreductase NP_302343.1 2380049 D 272631 CDS NP_302344.1 15828081 909094 2380915..2381466 1 NC_002677.1 hypothetical protein 2381466 909094 ML1993 Mycobacterium leprae TN hypothetical protein NP_302344.1 2380915 D 272631 CDS NP_302345.1 15828082 909091 2381496..2383094 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2383094 fadD10 909091 fadD10 Mycobacterium leprae TN acyl-CoA synthetase NP_302345.1 2381496 D 272631 CDS NP_302346.1 15828083 909087 2383087..2383323 1 NC_002677.1 hypothetical protein 2383323 909087 ML1995 Mycobacterium leprae TN hypothetical protein NP_302346.1 2383087 D 272631 CDS NP_302347.1 15828084 909086 2383320..2387525 1 NC_002677.1 peptide synthase 2387525 nrp 909086 nrp Mycobacterium leprae TN peptide synthase NP_302347.1 2383320 D 272631 CDS NP_302348.1 15828085 909083 complement(2387532..2388164) 1 NC_002677.1 hypothetical protein 2388164 909083 ML1997 Mycobacterium leprae TN hypothetical protein NP_302348.1 2387532 R 272631 CDS NP_302349.1 15828086 909080 2388277..2390256 1 NC_002677.1 hypothetical protein 2390256 909080 ML1998 Mycobacterium leprae TN hypothetical protein NP_302349.1 2388277 D 272631 CDS NP_302350.1 15828087 909077 complement(2391317..2393569) 1 NC_002677.1 cation-transporting ATPase 2393569 ctpB 909077 ctpB Mycobacterium leprae TN cation-transporting ATPase NP_302350.1 2391317 R 272631 CDS NP_302351.1 15828088 909065 2402973..2403434 1 NC_002677.1 lipoprotein 2403434 909065 ML2010 Mycobacterium leprae TN lipoprotein NP_302351.1 2402973 D 272631 CDS NP_302352.1 15828089 909061 2403489..2404451 1 NC_002677.1 D-amino acid oxidase 2404451 aao 909061 aao Mycobacterium leprae TN D-amino acid oxidase NP_302352.1 2403489 D 272631 CDS NP_302353.1 15828090 909059 complement(2404469..2404888) 1 NC_002677.1 hypothetical protein 2404888 909059 ML2012 Mycobacterium leprae TN hypothetical protein NP_302353.1 2404469 R 272631 CDS NP_302354.1 15828091 909056 complement(2405356..2405736) 1 NC_002677.1 hypothetical protein 2405736 909056 ML2013 Mycobacterium leprae TN hypothetical protein NP_302354.1 2405356 R 272631 CDS NP_302355.1 15828092 909054 complement(2407300..2408598) 1 NC_002677.1 competence damage-inducible protein A 2408598 cinA 909054 cinA Mycobacterium leprae TN competence damage-inducible protein A NP_302355.1 2407300 R 272631 CDS NP_302356.1 15828093 909047 2411315..2412229 1 NC_002677.1 hypothetical protein 2412229 909047 ML2020 Mycobacterium leprae TN hypothetical protein NP_302356.1 2411315 D 272631 CDS NP_302357.1 15828094 909045 complement(2413644..2414168) 1 NC_002677.1 hypothetical protein 2414168 909045 ML2022 Mycobacterium leprae TN hypothetical protein NP_302357.1 2413644 R 272631 CDS NP_302358.1 15828095 909044 complement(2414264..2414668) 1 NC_002677.1 hypothetical protein 2414668 909044 ML2023 Mycobacterium leprae TN hypothetical protein NP_302358.1 2414264 R 272631 CDS NP_302359.1 15828096 909036 2418620..2419603 1 NC_002677.1 antigen 85A, mycolyltransferase 2419603 fbpB 909036 fbpB Mycobacterium leprae TN antigen 85A, mycolyltransferase NP_302359.1 2418620 D 272631 CDS NP_302360.1 15828097 909030 2420647..2421120 1 NC_002677.1 hypothetical protein 2421120 909030 ML2030 Mycobacterium leprae TN hypothetical protein NP_302360.1 2420647 D 272631 CDS NP_302361.1 15828098 909028 2421151..2421606 1 NC_002677.1 hypothetical protein 2421606 909028 ML2031 Mycobacterium leprae TN hypothetical protein NP_302361.1 2421151 D 272631 CDS NP_302362.1 15828099 909020 complement(2425166..2425429) 1 NC_002677.1 hypothetical protein 2425429 909020 ML2035 Mycobacterium leprae TN hypothetical protein NP_302362.1 2425166 R 272631 CDS NP_302363.1 15828100 909017 complement(2429323..2429802) 1 NC_002677.1 bacterioferritin 2429802 bfrA 909017 bfrA Mycobacterium leprae TN bacterioferritin NP_302363.1 2429323 R 272631 CDS NP_302364.1 15828101 909008 complement(2431984..2432919) 1 NC_002677.1 LysR family transcriptional regulator 2432919 oxyR 909008 oxyR Mycobacterium leprae TN LysR family transcriptional regulator NP_302364.1 2431984 R 272631 CDS NP_302365.1 15828102 909002 2433029..2433616 1 NC_002677.1 alkyl hydroperoxide reductase 2433616 ahpC 909002 ahpC Mycobacterium leprae TN alkyl hydroperoxide reductase NP_302365.1 2433029 D 272631 CDS NP_302366.1 15828103 909000 complement(2434368..2434589) 1 NC_002677.1 hypothetical protein 2434589 909000 ML2044 Mycobacterium leprae TN hypothetical protein NP_302366.1 2434368 R 272631 CDS NP_302367.1 15828104 908999 2434998..2435255 1 NC_002677.1 hypothetical protein 2435255 908999 ML2045 Mycobacterium leprae TN hypothetical protein NP_302367.1 2434998 D 272631 CDS NP_302368.1 15828105 908996 2435559..2436803 1 NC_002677.1 L-lactate dehydrogenase 2436803 lldD2 908996 lldD2 Mycobacterium leprae TN L-lactate dehydrogenase NP_302368.1 2435559 D 272631 CDS NP_302369.1 15828106 908993 2437805..2438062 1 NC_002677.1 hypothetical protein 2438062 908993 ML2048 Mycobacterium leprae TN hypothetical protein NP_302369.1 2437805 D 272631 CDS NP_302370.1 15828107 908988 complement(2441097..2442104) 1 NC_002677.1 alcohol dehydrogenase 2442104 908988 ML2053 Mycobacterium leprae TN alcohol dehydrogenase NP_302370.1 2441097 R 272631 CDS NP_302371.1 15828108 908986 complement(2442182..2442481) 1 NC_002677.1 hypothetical protein 2442481 908986 ML2054 Mycobacterium leprae TN hypothetical protein NP_302371.1 2442182 R 272631 CDS NP_302372.1 15828109 908985 complement(2442641..2443504) 1 NC_002677.1 cell surface protein (associated with virulence) 2443504 modD 908985 modD Mycobacterium leprae TN cell surface protein (associated with virulence) NP_302372.1 2442641 R 272631 CDS NP_302373.1 15828110 908980 2446556..2447230 1 NC_002677.1 short chain dehydrogenase 2447230 908980 ML2059 Mycobacterium leprae TN short chain dehydrogenase NP_302373.1 2446556 D 272631 CDS NP_302374.1 15828111 908976 2448422..2449822 1 NC_002677.1 dehydrogenase 2449822 908976 ML2061 Mycobacterium leprae TN dehydrogenase NP_302374.1 2448422 D 272631 CDS NP_302375.1 15828112 908973 2450656..2451084 1 NC_002677.1 regulator 2451084 908973 ML2063 Mycobacterium leprae TN regulator NP_302375.1 2450656 D 272631 CDS NP_302376.1 15828113 908972 2451089..2452039 1 NC_002677.1 hypothetical protein 2452039 908972 ML2064 Mycobacterium leprae TN hypothetical protein NP_302376.1 2451089 D 272631 CDS NP_302377.1 15828114 908971 2452179..2453630 1 NC_002677.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2453630 gnd 908971 gnd Mycobacterium leprae TN 6-phosphogluconate dehydrogenase NP_302377.1 2452179 D 272631 CDS NP_302378.1 15828115 908961 2453700..2455136 1 NC_002677.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 2455136 guaB1 908961 guaB1 Mycobacterium leprae TN inosine 5-monophosphate dehydrogenase NP_302378.1 2453700 D 272631 CDS NP_302379.1 15828116 908958 2457996..2460191 1 NC_002677.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 2460191 glcB 908958 glcB Mycobacterium leprae TN malate synthase G NP_302379.1 2457996 D 272631 CDS NP_302380.1 15828117 910800 2460317..2462518 1 NC_002677.1 hypothetical protein 2462518 910800 ML2070 Mycobacterium leprae TN hypothetical protein NP_302380.1 2460317 D 272631 CDS NP_302381.1 15828118 908561 complement(2463419..2466277) 1 NC_002677.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2466277 gcvB 908561 gcvB Mycobacterium leprae TN glycine dehydrogenase NP_302381.1 2463419 R 272631 CDS NP_302382.1 15828119 908955 complement(2466445..2467140) 1 NC_002677.1 hypothetical protein 2467140 908955 ML2073 Mycobacterium leprae TN hypothetical protein NP_302382.1 2466445 R 272631 CDS NP_302383.1 15828120 908396 complement(2467373..2467867) 1 NC_002677.1 hypothetical protein 2467867 908396 ML2074 Mycobacterium leprae TN hypothetical protein NP_302383.1 2467373 R 272631 CDS NP_302384.1 15828121 908954 complement(2467984..2468739) 1 NC_002677.1 hypothetical protein 2468739 908954 ML2075 Mycobacterium leprae TN hypothetical protein NP_302384.1 2467984 R 272631 CDS NP_302385.1 15828122 908186 complement(2468736..2469224) 1 NC_002677.1 hypothetical protein 2469224 908186 ML2076 Mycobacterium leprae TN hypothetical protein NP_302385.1 2468736 R 272631 CDS NP_302386.1 15828123 909238 complement(2469468..2469866) 1 NC_002677.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2469866 gcvH 909238 gcvH Mycobacterium leprae TN glycine cleavage system protein H NP_302386.1 2469468 R 272631 CDS NP_302387.1 15828124 908950 complement(2472087..2472707) 1 NC_002677.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2472707 pgsA2 908950 pgsA2 Mycobacterium leprae TN CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NP_302387.1 2472087 R 272631 CDS NP_302388.1 15828125 908485 complement(2472769..2475105) 1 NC_002677.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 2475105 secA2 908485 secA2 Mycobacterium leprae TN preprotein translocase subunit SecA NP_302388.1 2472769 R 272631 CDS NP_302389.1 15828126 908947 complement(2475213..2476859) 1 NC_002677.1 hypothetical protein 2476859 ilvG 908947 ilvG Mycobacterium leprae TN hypothetical protein NP_302389.1 2475213 R 272631 CDS NP_302390.1 15828127 908477 2476953..2478869 1 NC_002677.1 multidrug resistance pump 2478869 908477 ML2084 Mycobacterium leprae TN multidrug resistance pump NP_302390.1 2476953 D 272631 CDS NP_302391.1 15828128 908944 complement(2481544..2482848) 1 NC_002677.1 cytochrome p450 2482848 908944 ML2088 Mycobacterium leprae TN cytochrome p450 NP_302391.1 2481544 R 272631 CDS NP_302392.1 15828129 908939 2487709..2487894 1 NC_002677.1 hypothetical protein 2487894 908939 ML2091 Mycobacterium leprae TN hypothetical protein NP_302392.1 2487709 D 272631 CDS NP_302393.1 15828130 908938 complement(2489131..2490045) 1 NC_002677.1 membrane-bound component of phosphate transport 2490045 pstA1 908938 pstA1 Mycobacterium leprae TN membrane-bound component of phosphate transport NP_302393.1 2489131 R 272631 CDS NP_302394.1 15828131 908937 complement(2490063..2491022) 1 NC_002677.1 membrane-bound component of phosphate transport 2491022 pstC2 908937 pstC2 Mycobacterium leprae TN membrane-bound component of phosphate transport NP_302394.1 2490063 R 272631 CDS NP_302395.1 15828132 908711 complement(2491065..2492174) 1 NC_002677.1 PstS component of phosphate uptake 2492174 phoS2 908711 phoS2 Mycobacterium leprae TN PstS component of phosphate uptake NP_302395.1 2491065 R 272631 CDS NP_302396.1 15828133 908932 2494502..2495782 1 NC_002677.1 manganese transport protein MntH 2495782 mntH 908932 mntH Mycobacterium leprae TN manganese transport protein MntH NP_302396.1 2494502 D 272631 CDS NP_302397.1 15828134 908213 complement(2512539..2512973) 1 NC_002677.1 hypothetical protein 2512973 908213 ML2111 Mycobacterium leprae TN hypothetical protein NP_302397.1 2512539 R 272631 CDS NP_302398.1 15828135 908791 complement(2513870..2514415) 1 NC_002677.1 hypothetical protein 2514415 908791 ML2113 Mycobacterium leprae TN hypothetical protein NP_302398.1 2513870 R 272631 CDS NP_302399.1 15828136 908915 complement(2514412..2514582) 1 NC_002677.1 hypothetical protein 2514582 908915 ML2114 Mycobacterium leprae TN hypothetical protein NP_302399.1 2514412 R 272631 CDS NP_302400.1 15828137 908912 complement(2518770..2519513) 1 NC_002677.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2519513 echA6 908912 echA6 Mycobacterium leprae TN enoyl-CoA hydratase NP_302400.1 2518770 R 272631 CDS NP_302401.1 15828138 908910 complement(2521540..2521950) 1 NC_002677.1 hypothetical protein 2521950 908910 ML2121 Mycobacterium leprae TN hypothetical protein NP_302401.1 2521540 R 272631 CDS NP_302402.1 15828139 908909 2524150..2524851 1 NC_002677.1 two-component response regulator 2524851 908909 ML2123 Mycobacterium leprae TN two-component response regulator NP_302402.1 2524150 D 272631 CDS NP_302403.1 15828140 910405 2524869..2526209 1 NC_002677.1 sensor histidine kinase 2526209 910405 ML2124 Mycobacterium leprae TN sensor histidine kinase NP_302403.1 2524869 D 272631 CDS NP_302404.1 15828141 908904 complement(2530687..2530848) 1 NC_002677.1 PE-family protein 2530848 908904 ML2129 Mycobacterium leprae TN PE-family protein NP_302404.1 2530687 R 272631 CDS NP_302405.1 15828142 909309 complement(2531614..2532909) 1 NC_002677.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 2532909 gltA 909309 gltA Mycobacterium leprae TN type II citrate synthase NP_302405.1 2531614 R 272631 CDS NP_302406.2 161723264 908903 complement(2533158..2533784) 1 NC_002677.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2533784 pdxH 908903 pdxH Mycobacterium leprae TN pyridoxamine 5'-phosphate oxidase NP_302406.2 2533158 R 272631 CDS NP_302407.1 15828144 909093 complement(2535813..2537480) 1 NC_002677.1 ferredoxin, ferredoxin-NADP reductase 2537480 fprB 909093 fprB Mycobacterium leprae TN ferredoxin, ferredoxin-NADP reductase NP_302407.1 2535813 R 272631 CDS NP_302408.1 15828145 908285 complement(2537496..2538521) 1 NC_002677.1 transmembrane protein 2538521 908285 ML2135 Mycobacterium leprae TN transmembrane protein NP_302408.1 2537496 R 272631 CDS NP_302409.1 15828146 908898 2538735..2539865 1 NC_002677.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 2539865 serC 908898 serC Mycobacterium leprae TN phosphoserine aminotransferase NP_302409.1 2538735 D 272631 CDS NP_302410.1 15828147 908321 2539983..2540738 1 NC_002677.1 hypothetical protein 2540738 908321 ML2137 Mycobacterium leprae TN hypothetical protein NP_302410.1 2539983 D 272631 CDS NP_302411.1 15828148 908892 complement(2541985..2542416) 1 NC_002677.1 MarR family transcriptional regulator 2542416 908892 ML2140 Mycobacterium leprae TN MarR family transcriptional regulator NP_302411.1 2541985 R 272631 CDS NP_302412.1 15828149 908891 2542620..2542895 1 NC_002677.1 hypothetical protein 2542895 908891 ML2141 Mycobacterium leprae TN hypothetical protein NP_302412.1 2542620 D 272631 CDS NP_302413.1 15828150 909161 complement(2543007..2543816) 1 NC_002677.1 hypothetical protein 2543816 909161 ML2142 Mycobacterium leprae TN hypothetical protein NP_302413.1 2543007 R 272631 CDS NP_302414.1 15828151 908890 2543926..2545665 1 NC_002677.1 hypothetical protein 2545665 908890 ML2143 Mycobacterium leprae TN hypothetical protein NP_302414.1 2543926 D 272631 CDS NP_302415.1 15828152 909301 2545673..2546161 1 NC_002677.1 hypothetical protein 2546161 909301 ML2144 Mycobacterium leprae TN hypothetical protein NP_302415.1 2545673 D 272631 CDS NP_302416.1 15828153 908888 complement(2552011..2552421) 1 NC_002677.1 cold shock protein 2552421 cspB 908888 cspB Mycobacterium leprae TN cold shock protein NP_302416.1 2552011 R 272631 CDS NP_302417.1 15828154 909175 2554745..2555269 1 NC_002677.1 hypothetical protein 2555269 909175 ML2151 Mycobacterium leprae TN hypothetical protein NP_302417.1 2554745 D 272631 CDS NP_302418.1 15828155 908308 complement(2556716..2556940) 1 NC_002677.1 hypothetical protein 2556940 908308 ML2155 Mycobacterium leprae TN hypothetical protein NP_302418.1 2556716 R 272631 CDS NP_302419.1 15828156 908878 2557038..2559299 1 NC_002677.1 DNA-binding protein 2559299 908878 ML2156 Mycobacterium leprae TN DNA-binding protein NP_302419.1 2557038 D 272631 CDS NP_302420.1 15828157 908199 2559336..2560985 1 NC_002677.1 DNA helicase 2560985 908199 ML2157 Mycobacterium leprae TN DNA helicase NP_302420.1 2559336 D 272631 CDS NP_302421.1 15828158 908343 complement(2561097..2561489) 1 NC_002677.1 hypothetical protein 2561489 908343 ML2158 Mycobacterium leprae TN hypothetical protein NP_302421.1 2561097 R 272631 CDS NP_302422.1 15828159 908456 complement(2569161..2571305) 1 NC_002677.1 fatty oxidation complex alpha subunit 2571305 fadB 908456 fadB Mycobacterium leprae TN fatty oxidation complex alpha subunit NP_302422.1 2569161 R 272631 CDS NP_302423.1 15828160 908875 complement(2571310..2572521) 1 NC_002677.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 2572521 fadA 908875 fadA Mycobacterium leprae TN acetyl-CoA acetyltransferase NP_302423.1 2571310 R 272631 CDS NP_302424.1 15828161 908871 2575965..2577674 1 NC_002677.1 pyruvate (or indolepyruvate) decarboxylase 2577674 pdc 908871 pdc Mycobacterium leprae TN pyruvate (or indolepyruvate) decarboxylase NP_302424.1 2575965 D 272631 CDS NP_302425.1 15828162 908867 complement(2579209..2579433) 1 NC_002677.1 hypothetical protein 2579433 908867 ML2170 Mycobacterium leprae TN hypothetical protein NP_302425.1 2579209 R 272631 CDS NP_302426.1 15828163 908866 2583247..2583603 1 NC_002677.1 hypothetical protein 2583603 908866 ML2172 Mycobacterium leprae TN hypothetical protein NP_302426.1 2583247 D 272631 CDS NP_302427.1 15828164 908480 2586141..2586545 1 NC_002677.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2586545 cdd 908480 cdd Mycobacterium leprae TN cytidine deaminase NP_302427.1 2586141 D 272631 CDS NP_302428.1 15828165 909284 2588187..2588444 1 NC_002677.1 hypothetical protein 2588444 909284 ML2176 Mycobacterium leprae TN hypothetical protein NP_302428.1 2588187 D 272631 CDS NP_302429.1 15828166 908859 complement(2588597..2589550) 1 NC_002677.1 uridine phosphorylase 2589550 908859 ML2177 Mycobacterium leprae TN uridine phosphorylase NP_302429.1 2588597 R 272631 CDS NP_302430.1 15828167 908858 complement(2589791..2590042) 1 NC_002677.1 hypothetical protein 2590042 908858 ML2178 Mycobacterium leprae TN hypothetical protein NP_302430.1 2589791 R 272631 CDS NP_302431.1 15828168 908845 2599216..2600232 1 NC_002677.1 acyl-[ACP] desaturase 2600232 desA1 908845 desA1 Mycobacterium leprae TN acyl-[ACP] desaturase NP_302431.1 2599216 D 272631 CDS NP_302432.1 15828169 909337 2600276..2601430 1 NC_002677.1 NifR3/Smm1 family transcriptional regulator 2601430 909337 ML2186 Mycobacterium leprae TN NifR3/Smm1 family transcriptional regulator NP_302432.1 2600276 D 272631 CDS NP_302433.1 15828170 909204 2603578..2604246 1 NC_002677.1 phosphate transport system regulator 2604246 phoY1 909204 phoY1 Mycobacterium leprae TN phosphate transport system regulator NP_302433.1 2603578 D 272631 CDS NP_302434.1 15828171 908843 complement(2604273..2605049) 1 NC_002677.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 2605049 phoT 908843 phoT Mycobacterium leprae TN phosphate transporter ATP-binding protein NP_302434.1 2604273 R 272631 CDS NP_302435.1 15828172 908840 complement(2606831..2608120) 1 NC_002677.1 phosphate-binding protein 3 2608120 phoS3 908840 phoS3 Mycobacterium leprae TN phosphate-binding protein 3 NP_302435.1 2606831 R 272631 CDS NP_302436.1 15828173 908928 complement(2608113..2609048) 1 NC_002677.1 acetyltransferase 2609048 908928 ML2193 Mycobacterium leprae TN acetyltransferase NP_302436.1 2608113 R 272631 CDS NP_302437.1 15828174 908837 2609965..2610816 1 NC_002677.1 hypothetical protein 2610816 908837 ML2195 Mycobacterium leprae TN hypothetical protein NP_302437.1 2609965 D 272631 CDS NP_302438.1 15828175 908935 2610909..2611331 1 NC_002677.1 thiredoxin 2611331 thiX 908935 thiX Mycobacterium leprae TN thiredoxin NP_302438.1 2610909 D 272631 CDS NP_302439.1 15828176 908885 2611544..2612029 1 NC_002677.1 hypothetical protein 2612029 908885 ML2197 Mycobacterium leprae TN hypothetical protein NP_302439.1 2611544 D 272631 CDS NP_302440.1 15828177 908836 2612061..2612894 1 NC_002677.1 thiosulfate sulfurtransferase 2612894 cysA3 908836 cysA3 Mycobacterium leprae TN thiosulfate sulfurtransferase NP_302440.1 2612061 D 272631 CDS NP_302441.1 15828178 908835 2612896..2613198 1 NC_002677.1 hypothetical protein 2613198 908835 ML2199 Mycobacterium leprae TN hypothetical protein NP_302441.1 2612896 D 272631 CDS NP_302442.1 15828179 908461 2613457..2614143 1 NC_002677.1 hypothetical protein 2614143 908461 ML2200 Mycobacterium leprae TN hypothetical protein NP_302442.1 2613457 D 272631 CDS NP_302443.1 15828180 908834 complement(2615448..2615687) 1 NC_002677.1 hypothetical protein 2615687 908834 ML2201 Mycobacterium leprae TN hypothetical protein NP_302443.1 2615448 R 272631 CDS NP_302444.1 15828181 908833 2617849..2618970 1 NC_002677.1 hypothetical protein 2618970 908833 ML2203 Mycobacterium leprae TN hypothetical protein NP_302444.1 2617849 D 272631 CDS NP_302445.1 15828182 908447 2619139..2619327 1 NC_002677.1 hypothetical protein 2619327 908447 ML2204 Mycobacterium leprae TN hypothetical protein NP_302445.1 2619139 D 272631 CDS NP_302446.1 15828183 908828 complement(2619421..2620515) 1 NC_002677.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2620515 purM 908828 purM Mycobacterium leprae TN phosphoribosylaminoimidazole synthetase NP_302446.1 2619421 R 272631 CDS NP_302447.1 15828184 908827 complement(2620615..2622285) 1 NC_002677.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2622285 purF 908827 purF Mycobacterium leprae TN amidophosphoribosyltransferase NP_302447.1 2620615 R 272631 CDS NP_302448.1 15828185 908510 complement(2622297..2622692) 1 NC_002677.1 hypothetical protein 2622692 908510 ML2207 Mycobacterium leprae TN hypothetical protein NP_302448.1 2622297 R 272631 CDS NP_302449.1 15828186 908309 2624324..2625952 1 NC_002677.1 UDP-glucose-4-epimerase 2625952 cpsY 908309 cpsY Mycobacterium leprae TN UDP-glucose-4-epimerase NP_302449.1 2624324 D 272631 CDS NP_302450.1 15828187 908821 complement(2625867..2626820) 1 NC_002677.1 hypothetical protein 2626820 908821 ML2210 Mycobacterium leprae TN hypothetical protein NP_302450.1 2625867 R 272631 CDS NP_302451.1 15828188 908524 complement(2626953..2629217) 1 NC_002677.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 2629217 purL 908524 purL Mycobacterium leprae TN phosphoribosylformylglycinamidine synthase II NP_302451.1 2626953 R 272631 CDS NP_302452.1 15828189 908471 complement(2630069..2631400) 1 NC_002677.1 catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 2631400 pepC 908471 pepC Mycobacterium leprae TN aminopeptidase NP_302452.1 2630069 R 272631 CDS NP_302453.1 15828190 908813 complement(2636005..2636679) 1 NC_002677.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 2636679 purQ 908813 purQ Mycobacterium leprae TN phosphoribosylformylglycinamidine synthase I NP_302453.1 2636005 R 272631 CDS NP_302454.1 15828191 908812 complement(2636676..2636915) 1 NC_002677.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 2636915 908812 ML2219A Mycobacterium leprae TN phosphoribosylformylglycinamidine synthase subunit PurS NP_302454.1 2636676 R 272631 CDS NP_302455.1 15828192 908152 complement(2642860..2645034) 1 NC_002677.1 oligopeptidase B 2645034 ptrB 908152 ptrB Mycobacterium leprae TN oligopeptidase B NP_302455.1 2642860 R 272631 CDS NP_302456.1 15828193 908227 complement(2645031..2645924) 1 NC_002677.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2645924 hemH 908227 hemH Mycobacterium leprae TN phosphoribosylaminoimidazole-succinocarboxamide synthase NP_302456.1 2645031 R 272631 CDS NP_302457.1 15828194 908200 2645990..2646610 1 NC_002677.1 hypothetical protein 2646610 908200 ML2228 Mycobacterium leprae TN hypothetical protein NP_302457.1 2645990 D 272631 CDS NP_302458.1 15828195 908158 complement(2647523..2648941) 1 NC_002677.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2648941 purB 908158 purB Mycobacterium leprae TN adenylosuccinate lyase NP_302458.1 2647523 R 272631 CDS NP_302459.1 15828196 908797 complement(2653337..2654605) 1 NC_002677.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 2654605 purD 908797 purD Mycobacterium leprae TN phosphoribosylamine--glycine ligase NP_302459.1 2653337 R 272631 CDS NP_302460.1 15828197 908360 2656446..2656850 1 NC_002677.1 hypothetical protein 2656850 908360 ML2237 Mycobacterium leprae TN hypothetical protein NP_302460.1 2656446 D 272631 CDS NP_302461.1 15828198 908784 complement(2661044..2661775) 1 NC_002677.1 hypothetical protein 2661775 908784 ML2242 Mycobacterium leprae TN hypothetical protein NP_302461.1 2661044 R 272631 CDS NP_302462.1 15828199 908783 complement(2667223..2667564) 1 NC_002677.1 hypothetical protein 2667564 908783 ML2244 Mycobacterium leprae TN hypothetical protein NP_302462.1 2667223 R 272631 CDS NP_302463.1 15828200 909381 2670322..2671872 1 NC_002677.1 hypothetical protein 2671872 cpsA 909381 cpsA Mycobacterium leprae TN hypothetical protein NP_302463.1 2670322 D 272631 CDS NP_302464.1 15828201 908463 complement(2672720..2673037) 1 NC_002677.1 hypothetical protein 2673037 908463 ML2249 Mycobacterium leprae TN hypothetical protein NP_302464.1 2672720 R 272631 CDS NP_302465.1 15828202 908777 complement(2675767..2676003) 1 NC_002677.1 hypothetical protein 2676003 908777 ML2252 Mycobacterium leprae TN hypothetical protein NP_302465.1 2675767 R 272631 CDS NP_302466.1 15828203 908863 complement(2676319..2676534) 1 NC_002677.1 antigen 84-like protein 2676534 908863 ML2253 Mycobacterium leprae TN antigen 84-like protein NP_302466.1 2676319 R 272631 CDS NP_302467.1 15828204 908776 2677263..2678759 1 NC_002677.1 trehalose-phosphate synthase 2678759 otsA 908776 otsA Mycobacterium leprae TN trehalose-phosphate synthase NP_302467.1 2677263 D 272631 CDS NP_302468.1 15828205 908454 complement(2681377..2682483) 1 NC_002677.1 O-succinylbenzoic acid--CoA ligase 2682483 menE 908454 menE Mycobacterium leprae TN O-succinylbenzoic acid--CoA ligase NP_302468.1 2681377 R 272631 CDS NP_302469.1 15828206 908768 complement(2682528..2682830) 1 NC_002677.1 hypothetical protein 2682830 908768 ML2258 Mycobacterium leprae TN hypothetical protein NP_302469.1 2682528 R 272631 CDS NP_302470.1 15828207 908211 complement(2682860..2683150) 1 NC_002677.1 hypothetical protein 2683150 908211 ML2259 Mycobacterium leprae TN hypothetical protein NP_302470.1 2682860 R 272631 CDS NP_302471.1 15828208 908765 complement(2683147..2684391) 1 NC_002677.1 low-affinity inorganic phosphate transporter 2684391 pitA 908765 pitA Mycobacterium leprae TN low-affinity inorganic phosphate transporter NP_302471.1 2683147 R 272631 CDS NP_302472.1 15828209 908761 complement(2684489..2684905) 1 NC_002677.1 hypothetical protein 2684905 908761 ML2261 Mycobacterium leprae TN hypothetical protein NP_302472.1 2684489 R 272631 CDS NP_302473.1 15828210 908760 complement(2686559..2687461) 1 NC_002677.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2687461 menB 908760 menB Mycobacterium leprae TN naphthoate synthase NP_302473.1 2686559 R 272631 CDS NP_302474.1 15828211 908759 complement(2687458..2688069) 1 NC_002677.1 hypothetical protein 2688069 908759 ML2264 Mycobacterium leprae TN hypothetical protein NP_302474.1 2687458 R 272631 CDS NP_302475.1 15828212 908150 complement(2688062..2688283) 1 NC_002677.1 hypothetical protein 2688283 908150 ML2265 Mycobacterium leprae TN hypothetical protein NP_302475.1 2688062 R 272631 CDS NP_302476.1 15828213 908756 2691797..2692801 1 NC_002677.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2692801 908756 ML2268 Mycobacterium leprae TN O-succinylbenzoate synthase NP_302476.1 2691797 D 272631 CDS NP_302477.1 15828214 908755 2692764..2693561 1 NC_002677.1 hydrolase 2693561 908755 ML2269 Mycobacterium leprae TN hydrolase NP_302477.1 2692764 D 272631 CDS NP_302478.1 15828215 908753 2693805..2695475 1 NC_002677.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2695475 menD 908753 menD Mycobacterium leprae TN 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase NP_302478.1 2693805 D 272631 CDS NP_302479.1 15828216 908751 2695503..2696030 1 NC_002677.1 hypothetical protein 2696030 908751 ML2271 Mycobacterium leprae TN hypothetical protein NP_302479.1 2695503 D 272631 CDS NP_302480.2 161723263 908749 2697307..2697999 1 NC_002677.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 2697999 ubiE 908749 ubiE Mycobacterium leprae TN ubiquinone/menaquinone biosynthesis methyltransferase NP_302480.2 2697307 D 272631 CDS NP_302481.1 15828218 908748 complement(2698017..2698355) 1 NC_002677.1 hypothetical protein 2698355 908748 ML2274 Mycobacterium leprae TN hypothetical protein NP_302481.1 2698017 R 272631 CDS NP_302482.1 15828219 908747 complement(2698907..2700133) 1 NC_002677.1 FAD-linked oxidoreductase 2700133 908747 ML2276 Mycobacterium leprae TN FAD-linked oxidoreductase NP_302482.1 2698907 R 272631 CDS NP_302483.1 15828220 908745 2700164..2701156 1 NC_002677.1 polyprenyl diphosphate synthase component 2701156 908745 ML2277 Mycobacterium leprae TN polyprenyl diphosphate synthase component NP_302483.1 2700164 D 272631 CDS NP_302484.1 15828221 908742 2701267..2702130 1 NC_002677.1 metalloprotease; heat shock protein HtpX 2702130 htpX 908742 htpX Mycobacterium leprae TN heat shock protein HtpX NP_302484.1 2701267 D 272631 CDS NP_302485.1 15828222 908420 complement(2702658..2704148) 1 NC_002677.1 transmembrane transport protein 2704148 908420 ML2279 Mycobacterium leprae TN transmembrane transport protein NP_302485.1 2702658 R 272631 CDS NP_302486.1 15828223 908739 2707732..2708046 1 NC_002677.1 hypothetical protein 2708046 908739 ML2283 Mycobacterium leprae TN hypothetical protein NP_302486.1 2707732 D 272631 CDS NP_302487.1 15828224 909250 2708438..2708797 1 NC_002677.1 hypothetical protein 2708797 909250 ML2284 Mycobacterium leprae TN hypothetical protein NP_302487.1 2708438 D 272631 CDS NP_302488.1 15828225 908232 complement(2712436..2712660) 1 NC_002677.1 hypothetical protein 2712660 908232 ML2288 Mycobacterium leprae TN hypothetical protein NP_302488.1 2712436 R 272631 CDS NP_302489.1 15828226 908735 complement(2713408..2714178) 1 NC_002677.1 hypothetical protein 2714178 908735 ML2289 Mycobacterium leprae TN hypothetical protein NP_302489.1 2713408 R 272631 CDS NP_302490.1 15828227 908732 complement(2720556..2721260) 1 NC_002677.1 hypothetical protein 2721260 908732 ML2295 Mycobacterium leprae TN hypothetical protein NP_302490.1 2720556 R 272631 CDS NP_302491.1 15828228 908730 2721464..2722009 1 NC_002677.1 hypothetical protein 2722009 908730 ML2296 Mycobacterium leprae TN hypothetical protein NP_302491.1 2721464 D 272631 CDS NP_302492.1 15828229 908207 2722010..2722984 1 NC_002677.1 hydrolase 2722984 908207 ML2297 Mycobacterium leprae TN hydrolase NP_302492.1 2722010 D 272631 CDS NP_302493.1 15828230 908147 complement(2722977..2724182) 1 NC_002677.1 membrane-associated serine protease 2724182 908147 ML2298 Mycobacterium leprae TN membrane-associated serine protease NP_302493.1 2722977 R 272631 CDS NP_302494.1 15828231 908214 complement(2724179..2724979) 1 NC_002677.1 hypothetical protein 2724979 908214 ML2299 Mycobacterium leprae TN hypothetical protein NP_302494.1 2724179 R 272631 CDS NP_302495.1 15828232 909282 complement(2725025..2725672) 1 NC_002677.1 hypothetical protein 2725672 909282 ML2300 Mycobacterium leprae TN hypothetical protein NP_302495.1 2725025 R 272631 CDS NP_302496.1 15828233 908145 complement(2725723..2726484) 1 NC_002677.1 endonuclease III 2726484 nth 908145 nth Mycobacterium leprae TN endonuclease III NP_302496.1 2725723 R 272631 CDS NP_302497.1 15828234 908399 2726910..2727584 1 NC_002677.1 Crp/Fnr family transcriptional regulator 2727584 908399 ML2302 Mycobacterium leprae TN Crp/Fnr family transcriptional regulator NP_302497.1 2726910 D 272631 CDS NP_302498.1 15828235 908724 complement(2727662..2728450) 1 NC_002677.1 hydrolase 2728450 908724 ML2303 Mycobacterium leprae TN hydrolase NP_302498.1 2727662 R 272631 CDS NP_302499.1 15828236 908723 complement(2728456..2728980) 1 NC_002677.1 hypothetical protein 2728980 908723 ML2304 Mycobacterium leprae TN hypothetical protein NP_302499.1 2728456 R 272631 CDS NP_302500.1 15828237 908495 2729191..2730216 1 NC_002677.1 anion transporter protein 2730216 908495 ML2305 Mycobacterium leprae TN anion transporter protein NP_302500.1 2729191 D 272631 CDS NP_302501.1 15828238 908722 2730213..2731358 1 NC_002677.1 anion transporter protein 2731358 908722 ML2306 Mycobacterium leprae TN anion transporter protein NP_302501.1 2730213 D 272631 CDS NP_302502.1 15828239 908721 complement(2731463..2731708) 1 NC_002677.1 hypothetical protein 2731708 908721 ML2307 Mycobacterium leprae TN hypothetical protein NP_302502.1 2731463 R 272631 CDS NP_302503.1 15828240 908216 2732187..2734598 1 NC_002677.1 penicillin binding protein (class A) 2734598 pon1 908216 pon1 Mycobacterium leprae TN penicillin binding protein (class A) NP_302503.1 2732187 D 272631 CDS NP_302504.1 15828241 908720 2734787..2735779 1 NC_002677.1 hypothetical protein 2735779 908720 ML2309 Mycobacterium leprae TN hypothetical protein NP_302504.1 2734787 D 272631 CDS NP_302505.1 15828242 908202 2739921..2740511 1 NC_002677.1 hypothetical protein 2740511 908202 ML2312 Mycobacterium leprae TN hypothetical protein NP_302505.1 2739921 D 272631 CDS NP_302506.1 15828243 908716 2740945..2741547 1 NC_002677.1 hypothetical protein 2741547 908716 ML2313 Mycobacterium leprae TN hypothetical protein NP_302506.1 2740945 D 272631 CDS NP_302507.1 15828244 908659 complement(2741813..2743339) 1 NC_002677.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 2743339 glpK 908659 glpK Mycobacterium leprae TN glycerol kinase NP_302507.1 2741813 R 272631 CDS NP_302508.1 15828245 908648 complement(2747152..2747799) 1 NC_002677.1 hypothetical protein 2747799 908648 ML2320 Mycobacterium leprae TN hypothetical protein NP_302508.1 2747152 R 272631 CDS NP_302509.1 15828246 908700 complement(2750468..2751478) 1 NC_002677.1 hypothetical protein 2751478 908700 ML2321 Mycobacterium leprae TN hypothetical protein NP_302509.1 2750468 R 272631 CDS NP_302510.1 15828247 908669 complement(2751624..2752679) 1 NC_002677.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 2752679 asd 908669 asd Mycobacterium leprae TN aspartate-semialdehyde dehydrogenase NP_302510.1 2751624 R 272631 CDS NP_302511.1 15828248 908699 complement(2752679..2753944) 1 NC_002677.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 2753944 ask 908699 ask Mycobacterium leprae TN aspartate kinase NP_302511.1 2752679 R 272631 CDS NP_302512.2 161723262 908681 2754769..2756463 1 NC_002677.1 2-isopropylmalate synthase 2756463 leuA 908681 leuA Mycobacterium leprae TN 2-isopropylmalate synthase NP_302512.2 2754769 D 272631 CDS NP_302513.1 15828250 908692 2757741..2758976 1 NC_002677.1 ligase 2758976 908692 ML2326 Mycobacterium leprae TN ligase NP_302513.1 2757741 D 272631 CDS NP_302514.1 15828251 908691 2758984..2759676 1 NC_002677.1 hypothetical protein 2759676 908691 ML2327 Mycobacterium leprae TN hypothetical protein NP_302514.1 2758984 D 272631 CDS NP_302515.1 15828252 908695 complement(2760630..2761241) 1 NC_002677.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 2761241 recR 908695 recR Mycobacterium leprae TN recombination protein RecR NP_302515.1 2760630 R 272631 CDS NP_302516.1 15828253 908677 complement(2761253..2761603) 1 NC_002677.1 hypothetical protein 2761603 908677 ML2330 Mycobacterium leprae TN hypothetical protein NP_302516.1 2761253 R 272631 CDS NP_302517.1 15828254 908688 2761703..2762473 1 NC_002677.1 hypothetical protein 2762473 908688 ML2331 Mycobacterium leprae TN hypothetical protein NP_302517.1 2761703 D 272631 CDS NP_302518.1 15828255 908687 complement(2762489..2762926) 1 NC_002677.1 hypothetical protein 2762926 908687 ML2332 Mycobacterium leprae TN hypothetical protein NP_302518.1 2762489 R 272631 CDS NP_302519.1 15828256 908651 2763015..2764394 1 NC_002677.1 hypothetical protein 2764394 908651 ML2333 Mycobacterium leprae TN hypothetical protein NP_302519.1 2763015 D 272631 CDS NP_302520.1 15828257 908686 2764448..2765710 1 NC_002677.1 hypothetical protein 2765710 908686 ML2334 Mycobacterium leprae TN hypothetical protein NP_302520.1 2764448 D 272631 CDS NP_302521.1 15828258 908684 complement(2765707..2767542) 1 NC_002677.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 2767542 dnaZX 908684 dnaZX Mycobacterium leprae TN DNA polymerase III subunits gamma and tau NP_302521.1 2765707 R 272631 CDS NP_302522.1 15828259 908683 complement(2767652..2769043) 1 NC_002677.1 hypothetical protein 2769043 908683 ML2336 Mycobacterium leprae TN hypothetical protein NP_302522.1 2767652 R 272631 CDS NP_302523.1 15828260 908685 2769442..2770194 1 NC_002677.1 hypothetical protein 2770194 908685 ML2337 Mycobacterium leprae TN hypothetical protein NP_302523.1 2769442 D 272631 CDS NP_302524.1 15828261 908369 complement(2779477..2781675) 1 NC_002677.1 regulatory protein 2781675 908369 ML2341 Mycobacterium leprae TN regulatory protein NP_302524.1 2779477 R 272631 CDS NP_302525.1 15828262 908676 complement(2787096..2788001) 1 NC_002677.1 hypothetical protein 2788001 908676 ML2346 Mycobacterium leprae TN hypothetical protein NP_302525.1 2787096 R 272631 CDS NP_302526.1 15828263 908672 2788300..2789310 1 NC_002677.1 hypothetical protein 2789310 908672 ML2347 Mycobacterium leprae TN hypothetical protein NP_302526.1 2788300 D 272631 CDS NP_302527.1 15828264 908657 2789501..2790766 1 NC_002677.1 glycosyl transferase family protein 2790766 908657 ML2348 Mycobacterium leprae TN glycosyl transferase family protein NP_302527.1 2789501 D 272631 CDS NP_302528.1 15828265 908671 complement(2790912..2792183) 1 NC_002677.1 required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase 2792183 908671 ML2349 Mycobacterium leprae TN acyltransferase NP_302528.1 2790912 R 272631 CDS NP_302529.1 15828266 908701 complement(2792232..2793062) 1 NC_002677.1 antibiotic resistance membrane protein 2793062 908701 ML2350 Mycobacterium leprae TN antibiotic resistance membrane protein NP_302529.1 2792232 R 272631 CDS NP_302530.1 15828267 908670 complement(2793059..2793925) 1 NC_002677.1 antibiotic resistance membrane protein 2793925 908670 ML2351 Mycobacterium leprae TN antibiotic resistance membrane protein NP_302530.1 2793059 R 272631 CDS NP_302531.1 15828268 908391 complement(2793922..2794917) 1 NC_002677.1 antibiotic resistance efflux protein 2794917 908391 ML2352 Mycobacterium leprae TN antibiotic resistance efflux protein NP_302531.1 2793922 R 272631 CDS NP_302532.1 15828269 908668 complement(2794928..2799397) 1 NC_002677.1 polyketide synthase 2799397 908668 ML2353 Mycobacterium leprae TN polyketide synthase NP_302532.1 2794928 R 272631 CDS NP_302533.1 15828270 909375 complement(2799404..2804872) 1 NC_002677.1 polyketide synthase 2804872 909375 ML2354 Mycobacterium leprae TN polyketide synthase NP_302533.1 2799404 R 272631 CDS NP_302534.1 15828271 908660 complement(2804869..2811474) 1 NC_002677.1 polyketide synthase 2811474 908660 ML2355 Mycobacterium leprae TN polyketide synthase NP_302534.1 2804869 R 272631 CDS NP_302535.1 15828272 908658 complement(2811471..2816093) 1 NC_002677.1 polyketide synthase 2816093 908658 ML2356 Mycobacterium leprae TN polyketide synthase NP_302535.1 2811471 R 272631 CDS NP_302536.1 15828273 908254 complement(2816094..2821709) 1 NC_002677.1 polyketide synthase 2821709 908254 ML2357 Mycobacterium leprae TN polyketide synthase NP_302536.1 2816094 R 272631 CDS NP_302537.1 15828274 908645 complement(2821706..2823457) 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2823457 fadD26 908645 fadD26 Mycobacterium leprae TN acyl-CoA synthetase NP_302537.1 2821706 R 272631 CDS NP_302538.1 15828275 908644 complement(2824103..2824888) 1 NC_002677.1 thioesterase 2824888 908644 ML2359 Mycobacterium leprae TN thioesterase NP_302538.1 2824103 R 272631 CDS NP_302539.1 15828276 909324 complement(2834617..2834958) 1 NC_002677.1 hypothetical protein 2834958 909324 ML2366 Mycobacterium leprae TN hypothetical protein NP_302539.1 2834617 R 272631 CDS NP_302540.1 15828277 908627 2846366..2846830 1 NC_002677.1 small membrane protein 2846830 908627 ML2377 Mycobacterium leprae TN small membrane protein NP_302540.1 2846366 D 272631 CDS NP_302541.1 15828278 908370 2846827..2849706 1 NC_002677.1 large membrane protein 2849706 908370 ML2378 Mycobacterium leprae TN large membrane protein NP_302541.1 2846827 D 272631 CDS NP_302542.1 15828279 908448 complement(2849880..2850209) 1 NC_002677.1 hypothetical protein 2850209 908448 ML2379 Mycobacterium leprae TN hypothetical protein NP_302542.1 2849880 R 272631 CDS NP_302543.1 15828280 908626 complement(2850483..2850944) 1 NC_002677.1 hypothetical protein 2850944 908626 ML2380 Mycobacterium leprae TN hypothetical protein NP_302543.1 2850483 R 272631 CDS NP_302544.1 15828281 908174 2856881..2858284 1 NC_002677.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 2858284 lpd 908174 lpd Mycobacterium leprae TN dihydrolipoamide dehydrogenase NP_302544.1 2856881 D 272631 CDS NP_302545.1 15828282 908619 2858302..2858607 1 NC_002677.1 hypothetical protein 2858607 908619 ML2388 Mycobacterium leprae TN hypothetical protein NP_302545.1 2858302 D 272631 CDS NP_302546.1 15828283 909635 complement(2861300..2861605) 1 NC_002677.1 hypothetical protein 2861605 909635 ML2390 Mycobacterium leprae TN hypothetical protein NP_302546.1 2861300 R 272631 CDS NP_302547.1 15828284 908614 complement(2861602..2862474) 1 NC_002677.1 hypothetical protein 2862474 908614 ML2391 Mycobacterium leprae TN hypothetical protein NP_302547.1 2861602 R 272631 CDS NP_302548.1 15828285 908693 2862579..2863013 1 NC_002677.1 hypothetical protein 2863013 908693 ML2392 Mycobacterium leprae TN hypothetical protein NP_302548.1 2862579 D 272631 CDS NP_302549.1 15828286 908542 2863237..2863731 1 NC_002677.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 2863731 greA 908542 greA Mycobacterium leprae TN transcription elongation factor GreA NP_302549.1 2863237 D 272631 CDS NP_302550.1 15828287 908547 complement(2863794..2864960) 1 NC_002677.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 2864960 metB 908547 metB Mycobacterium leprae TN cystathionine gamma-synthase NP_302550.1 2863794 R 272631 CDS NP_302551.1 15828288 908610 complement(2865040..2865789) 1 NC_002677.1 hypothetical protein 2865789 Ag36 908610 Ag36 Mycobacterium leprae TN hypothetical protein NP_302551.1 2865040 R 272631 CDS NP_302552.1 15828289 908609 complement(2865939..2867333) 1 NC_002677.1 cystathionine [beta]-synthase 2867333 cysM2 908609 cysM2 Mycobacterium leprae TN cystathionine [beta]-synthase NP_302552.1 2865939 R 272631 CDS NP_302553.1 15828290 908606 complement(2870652..2871509) 1 NC_002677.1 transmembrane protein 2871509 908606 ML2400 Mycobacterium leprae TN transmembrane protein NP_302553.1 2870652 R 272631 CDS NP_302554.1 15828291 908605 2871769..2872806 1 NC_002677.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 2872806 908605 ML2401 Mycobacterium leprae TN 3-hydroxyisobutyryl-CoA hydrolase NP_302554.1 2871769 D 272631 CDS NP_302555.1 15828292 908604 2872831..2873604 1 NC_002677.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2873604 908604 ML2402 Mycobacterium leprae TN enoyl-CoA hydratase NP_302555.1 2872831 D 272631 CDS NP_302556.1 15828293 908601 2877398..2878282 1 NC_002677.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 2878282 908601 ML2406 Mycobacterium leprae TN 1,4-dihydroxy-2-naphthoate octaprenyltransferase NP_302556.1 2877398 D 272631 CDS NP_302557.1 15828294 908224 complement(2878350..2878685) 1 NC_002677.1 hypothetical protein 2878685 908224 ML2407 Mycobacterium leprae TN hypothetical protein NP_302557.1 2878350 R 272631 CDS NP_302558.1 15828295 908580 complement(2880041..2881024) 1 NC_002677.1 cytochrome C biogenesis protein 2881024 908580 ML2409 Mycobacterium leprae TN cytochrome C biogenesis protein NP_302558.1 2880041 R 272631 CDS NP_302559.1 15828296 908437 complement(2881021..2882649) 1 NC_002677.1 hypothetical protein 2882649 908437 ML2410 Mycobacterium leprae TN hypothetical protein NP_302559.1 2881021 R 272631 CDS NP_302560.1 15828297 908597 complement(2882646..2883434) 1 NC_002677.1 cytochrome C-type biogenesis protein 2883434 908597 ML2411 Mycobacterium leprae TN cytochrome C-type biogenesis protein NP_302560.1 2882646 R 272631 CDS NP_302561.1 15828298 908433 complement(2883431..2884099) 1 NC_002677.1 hypothetical protein 2884099 908433 ML2412 Mycobacterium leprae TN hypothetical protein NP_302561.1 2883431 R 272631 CDS NP_302562.1 15828299 908591 complement(2884096..2884704) 1 NC_002677.1 phosphoglycerate mutase 2884704 908591 ML2413 Mycobacterium leprae TN phosphoglycerate mutase NP_302562.1 2884096 R 272631 CDS NP_302563.1 15828300 908589 complement(2884704..2886044) 1 NC_002677.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 2886044 hemL 908589 hemL Mycobacterium leprae TN glutamate-1-semialdehyde aminotransferase NP_302563.1 2884704 R 272631 CDS NP_302564.1 15828301 908581 complement(2893799..2894788) 1 NC_002677.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 2894788 hemB 908581 hemB Mycobacterium leprae TN delta-aminolevulinic acid dehydratase NP_302564.1 2893799 R 272631 CDS NP_302565.1 15828302 908323 complement(2894835..2896526) 1 NC_002677.1 uroporphyrin-III C-methyltransferase 2896526 hemD 908323 hemD Mycobacterium leprae TN uroporphyrin-III C-methyltransferase NP_302565.1 2894835 R 272631 CDS NP_302566.1 15828303 908457 complement(2896533..2897489) 1 NC_002677.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 2897489 hemC 908457 hemC Mycobacterium leprae TN porphobilinogen deaminase NP_302566.1 2896533 R 272631 CDS NP_302567.1 15828304 909785 complement(2897494..2898897) 1 NC_002677.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 2898897 hemA 909785 hemA Mycobacterium leprae TN glutamyl-tRNA reductase NP_302567.1 2897494 R 272631 CDS NP_302568.1 15828305 908575 2899999..2900901 1 NC_002677.1 hypothetical protein 2900901 908575 ML2424 Mycobacterium leprae TN hypothetical protein NP_302568.1 2899999 D 272631 CDS NP_302569.1 15828306 909327 2901005..2901505 1 NC_002677.1 hypothetical protein 2901505 909327 ML2425 Mycobacterium leprae TN hypothetical protein NP_302569.1 2901005 D 272631 CDS NP_302570.1 15828307 908573 2901516..2902442 1 NC_002677.1 cyclopropane mycolic acid synthase 2902442 cmaA2 908573 cmaA2 Mycobacterium leprae TN cyclopropane mycolic acid synthase NP_302570.1 2901516 D 272631 CDS NP_302571.1 15828308 908458 complement(2902471..2903583) 1 NC_002677.1 hypothetical protein 2903583 908458 ML2427 Mycobacterium leprae TN hypothetical protein NP_302571.1 2902471 R 272631 CDS NP_302572.1 15828309 908362 complement(2903580..2904674) 1 NC_002677.1 glucose epimerase/dehydratase 2904674 908362 ML2428 Mycobacterium leprae TN glucose epimerase/dehydratase NP_302572.1 2903580 R 272631 CDS NP_302573.1 15828310 908568 complement(2904745..2904846) 1 NC_002677.1 hypothetical protein 2904846 908568 ML2428A Mycobacterium leprae TN hypothetical protein NP_302573.1 2904745 R 272631 CDS NP_302574.1 15828311 908567 complement(2905089..2905349) 1 NC_002677.1 DNA-binding protein 2905349 908567 ML2429 Mycobacterium leprae TN DNA-binding protein NP_302574.1 2905089 R 272631 CDS NP_302575.1 15828312 908565 complement(2905490..2906374) 1 NC_002677.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 2906374 proC 908565 proC Mycobacterium leprae TN pyrroline-5-carboxylate reductase NP_302575.1 2905490 R 272631 CDS NP_302576.1 15828313 908559 complement(2907135..2907977) 1 NC_002677.1 hypothetical protein 2907977 908559 ML2432 Mycobacterium leprae TN hypothetical protein NP_302576.1 2907135 R 272631 CDS NP_302577.1 15828314 909235 complement(2908008..2909075) 1 NC_002677.1 hypothetical protein 2909075 909235 ML2433 Mycobacterium leprae TN hypothetical protein NP_302577.1 2908008 R 272631 CDS NP_302578.1 15828315 908558 complement(2909072..2910091) 1 NC_002677.1 hypothetical protein 2910091 908558 ML2434 Mycobacterium leprae TN hypothetical protein NP_302578.1 2909072 R 272631 CDS NP_302579.1 15828316 908552 2910195..2911028 1 NC_002677.1 hypothetical protein 2911028 908552 ML2435 Mycobacterium leprae TN hypothetical protein NP_302579.1 2910195 D 272631 CDS NP_302580.1 15828317 908548 complement(2914489..2915085) 1 NC_002677.1 two-component system response regulator 2915085 908548 ML2439 Mycobacterium leprae TN two-component system response regulator NP_302580.1 2914489 R 272631 CDS NP_302581.1 15828318 908546 complement(2915128..2916453) 1 NC_002677.1 two-component system sensor histidine kinase 2916453 908546 ML2440 Mycobacterium leprae TN two-component system sensor histidine kinase NP_302581.1 2915128 R 272631 CDS NP_302582.1 15828319 908545 complement(2916616..2917359) 1 NC_002677.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 2917359 gpmA 908545 gpmA Mycobacterium leprae TN phosphoglyceromutase NP_302582.1 2916616 R 272631 CDS NP_302583.1 15828320 908544 complement(2917372..2917926) 1 NC_002677.1 hypothetical protein 2917926 908544 ML2442 Mycobacterium leprae TN hypothetical protein NP_302583.1 2917372 R 272631 CDS NP_302584.1 15828321 908203 complement(2918000..2919286) 1 NC_002677.1 glycosyl transferase family protein 2919286 908203 ML2443 Mycobacterium leprae TN glycosyl transferase family protein NP_302584.1 2918000 R 272631 CDS NP_302585.1 15828322 908347 complement(2921383..2922708) 1 NC_002677.1 lipoprotein 2922708 908347 ML2446 Mycobacterium leprae TN lipoprotein NP_302585.1 2921383 R 272631 CDS NP_302586.1 15828323 908302 complement(2922789..2923892) 1 NC_002677.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 2923892 murB 908302 murB Mycobacterium leprae TN UDP-N-acetylenolpyruvoylglucosamine reductase NP_302586.1 2922789 R 272631 CDS NP_302587.1 15828324 908531 2924641..2925456 1 NC_002677.1 hydrolase 2925456 908531 ML2449 Mycobacterium leprae TN hydrolase NP_302587.1 2924641 D 272631 CDS NP_302588.1 15828325 908371 2925762..2926499 1 NC_002677.1 hypothetical protein 2926499 908371 ML2450 Mycobacterium leprae TN hypothetical protein NP_302588.1 2925762 D 272631 CDS NP_302589.1 15828326 908530 complement(2926556..2927236) 1 NC_002677.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 2927236 deoC 908530 deoC Mycobacterium leprae TN deoxyribose-phosphate aldolase NP_302589.1 2926556 R 272631 CDS NP_302590.1 15828327 908528 complement(2927236..2927607) 1 NC_002677.1 hypothetical protein 2927607 908528 ML2452 Mycobacterium leprae TN hypothetical protein NP_302590.1 2927236 R 272631 CDS NP_302591.1 15828328 909786 complement(2927710..2927997) 1 NC_002677.1 hypothetical protein 2927997 909786 ML2453 Mycobacterium leprae TN hypothetical protein NP_302591.1 2927710 R 272631 CDS NP_302592.1 15828329 908523 complement(2928117..2928683) 1 NC_002677.1 hemagglutinin 2928683 908523 ML2454 Mycobacterium leprae TN hemagglutinin NP_302592.1 2928117 R 272631 CDS NP_302593.1 15828330 908519 2930178..2930879 1 NC_002677.1 TetR family transcriptional regulator 2930879 908519 ML2457 Mycobacterium leprae TN TetR family transcriptional regulator NP_302593.1 2930178 D 272631 CDS NP_302594.1 15828331 908512 2932062..2932949 1 NC_002677.1 mycolic acid synthase 2932949 umaA2 908512 umaA2 Mycobacterium leprae TN mycolic acid synthase NP_302594.1 2932062 D 272631 CDS NP_302595.1 15828332 908515 complement(2934086..2934949) 1 NC_002677.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 2934949 fadB2 908515 fadB2 Mycobacterium leprae TN 3-hydroxybutyryl-CoA dehydrogenase NP_302595.1 2934086 R 272631 CDS NP_302596.1 15828333 908229 complement(2936751..2937545) 1 NC_002677.1 hypothetical protein 2937545 908229 ML2463 Mycobacterium leprae TN hypothetical protein NP_302596.1 2936751 R 272631 CDS NP_302597.1 15828334 908595 2939177..2939743 1 NC_002677.1 hypothetical protein 2939743 908595 ML2465 Mycobacterium leprae TN hypothetical protein NP_302597.1 2939177 D 272631 CDS NP_302598.1 15828335 908506 2940904..2941692 1 NC_002677.1 undecaprenyl pyrophosphate synthetase 2941692 908506 ML2467 Mycobacterium leprae TN undecaprenyl pyrophosphate synthetase NP_302598.1 2940904 D 272631 CDS NP_302599.1 15828336 908164 complement(2942027..2942407) 1 NC_002677.1 hypothetical protein 2942407 908164 ML2468 Mycobacterium leprae TN hypothetical protein NP_302599.1 2942027 R 272631 CDS NP_302600.1 15828337 908169 complement(2947158..2948141) 1 NC_002677.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 2948141 908169 ML2472 Mycobacterium leprae TN prephenate dehydrogenase NP_302600.1 2947158 R 272631 CDS NP_302601.1 15828338 908518 2948272..2948751 1 NC_002677.1 hypothetical protein 2948751 908518 ML2473 Mycobacterium leprae TN hypothetical protein NP_302601.1 2948272 D 272631 CDS NP_302602.1 15828339 908496 2948766..2949281 1 NC_002677.1 cytidine/deoxycytidylate deaminase 2949281 908496 ML2474 Mycobacterium leprae TN cytidine/deoxycytidylate deaminase NP_302602.1 2948766 D 272631 CDS NP_302603.1 15828340 908488 complement(2950639..2950806) 1 NC_002677.1 hypothetical protein 2950806 908488 ML2476 Mycobacterium leprae TN hypothetical protein NP_302603.1 2950639 R 272631 CDS NP_302604.1 15828341 908487 complement(2952757..2953146) 1 NC_002677.1 hypothetical protein 2953146 908487 ML2478 Mycobacterium leprae TN hypothetical protein NP_302604.1 2952757 R 272631 CDS NP_302605.1 15828342 908219 complement(2959460..2960008) 1 NC_002677.1 RNA methyltransferase 2960008 908219 ML2485 Mycobacterium leprae TN RNA methyltransferase NP_302605.1 2959460 R 272631 CDS NP_302606.1 15828343 908475 complement(2961000..2961539) 1 NC_002677.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 2961539 pyrE 908475 pyrE Mycobacterium leprae TN orotate phosphoribosyltransferase NP_302606.1 2961000 R 272631 CDS NP_302607.1 15828344 908170 complement(2962275..2963135) 1 NC_002677.1 hypothetical protein 2963135 908170 ML2489 Mycobacterium leprae TN hypothetical protein NP_302607.1 2962275 R 272631 CDS NP_302608.1 15828345 908472 complement(2963220..2965766) 1 NC_002677.1 heat shock protein 2965766 clpB 908472 clpB Mycobacterium leprae TN heat shock protein NP_302608.1 2963220 R 272631 CDS NP_302609.1 15828346 908469 2966697..2967698 1 NC_002677.1 hypothetical protein 2967698 908469 ML2491 Mycobacterium leprae TN hypothetical protein NP_302609.1 2966697 D 272631 CDS NP_302610.1 15828347 908468 complement(2969298..2969696) 1 NC_002677.1 heat shock regulator 2969696 hspR 908468 hspR Mycobacterium leprae TN heat shock regulator NP_302610.1 2969298 R 272631 CDS NP_302611.1 15828348 908467 complement(2969700..2970866) 1 NC_002677.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 2970866 dnaJ 908467 dnaJ Mycobacterium leprae TN molecular chaperone DnaJ NP_302611.1 2969700 R 272631 CDS NP_302612.1 15828349 908465 complement(2970880..2971569) 1 NC_002677.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2971569 grpE 908465 grpE Mycobacterium leprae TN heat shock protein GrpE NP_302612.1 2970880 R 272631 CDS NP_302613.1 15828350 908588 complement(2971566..2973428) 1 NC_002677.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 2973428 dnaK 908588 dnaK Mycobacterium leprae TN molecular chaperone DnaK NP_302613.1 2971566 R 272631 CDS NP_302614.1 15828351 908462 2974117..2974590 1 NC_002677.1 hypothetical protein 2974590 908462 ML2497 Mycobacterium leprae TN hypothetical protein NP_302614.1 2974117 D 272631 CDS NP_302615.1 15828352 908304 2974620..2975279 1 NC_002677.1 enoyl-CoA hydratase 2975279 908304 ML2498 Mycobacterium leprae TN enoyl-CoA hydratase NP_302615.1 2974620 D 272631 CDS NP_302616.1 15828353 908459 2980181..2982823 1 NC_002677.1 iron-sulfur-binding reductase 2982823 908459 ML2501 Mycobacterium leprae TN iron-sulfur-binding reductase NP_302616.1 2980181 D 272631 CDS NP_302617.1 15828354 908455 2982832..2984145 1 NC_002677.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2984145 908455 ML2502 Mycobacterium leprae TN aminotransferase NP_302617.1 2982832 D 272631 CDS NP_302618.1 15828355 908452 complement(2984300..2985166) 1 NC_002677.1 glucose-1-phosphate thymidylyltransferase 2985166 rfbA 908452 rfbA Mycobacterium leprae TN glucose-1-phosphate thymidylyltransferase NP_302618.1 2984300 R 272631 CDS NP_302619.1 15828356 910802 complement(2987949..2988521) 1 NC_002677.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2988521 dcd 910802 dcd Mycobacterium leprae TN deoxycytidine triphosphate deaminase NP_302619.1 2987949 R 272631 CDS NP_302620.1 15828357 908440 complement(2999816..3000208) 1 NC_002677.1 hypothetical protein 3000208 908440 ML2518 Mycobacterium leprae TN hypothetical protein NP_302620.1 2999816 R 272631 CDS NP_302621.1 15828358 910807 complement(3004590..3005246) 1 NC_002677.1 hypothetical protein 3005246 910807 ML2522 Mycobacterium leprae TN hypothetical protein NP_302621.1 3004590 R 272631 CDS NP_302622.1 15828359 908427 complement(3009256..3010275) 1 NC_002677.1 hypothetical protein 3010275 908427 ML2527 Mycobacterium leprae TN hypothetical protein NP_302622.1 3009256 R 272631 CDS NP_302623.1 15828360 910803 complement(3010272..3011699) 1 NC_002677.1 protease 3011699 910803 ML2528 Mycobacterium leprae TN protease NP_302623.1 3010272 R 272631 CDS NP_302624.1 15828361 910804 complement(3011710..3013167) 1 NC_002677.1 hypothetical protein 3013167 910804 ML2529 Mycobacterium leprae TN hypothetical protein NP_302624.1 3011710 R 272631 CDS NP_302625.1 15828362 908426 complement(3013309..3014178) 1 NC_002677.1 DNA-binding protein 3014178 908426 ML2530 Mycobacterium leprae TN DNA-binding protein NP_302625.1 3013309 R 272631 CDS NP_302626.1 15828363 908479 complement(3014189..3014479) 1 NC_002677.1 cell surface protein 3014479 908479 ML2531 Mycobacterium leprae TN cell surface protein NP_302626.1 3014189 R 272631 CDS NP_302627.1 15828364 908424 complement(3014518..3014814) 1 NC_002677.1 PE-family protein 3014814 908424 ML2532 Mycobacterium leprae TN PE-family protein NP_302627.1 3014518 R 272631 CDS NP_302628.1 15828365 910907 complement(3016103..3016411) 1 NC_002677.1 PE-family protein 3016411 910907 ML2534 Mycobacterium leprae TN PE-family protein NP_302628.1 3016103 R 272631 CDS NP_302629.1 15828366 908421 complement(3016446..3020435) 1 NC_002677.1 hypothetical protein 3020435 908421 ML2535 Mycobacterium leprae TN hypothetical protein NP_302629.1 3016446 R 272631 CDS NP_302630.1 15828367 910905 complement(3020432..3022090) 1 NC_002677.1 hypothetical protein 3022090 910905 ML2536 Mycobacterium leprae TN hypothetical protein NP_302630.1 3020432 R 272631 CDS NP_302631.1 15828368 908418 complement(3022083..3024005) 1 NC_002677.1 hypothetical protein 3024005 908418 ML2537 Mycobacterium leprae TN hypothetical protein NP_302631.1 3022083 R 272631 CDS NP_302632.1 15828369 910899 complement(3033660..3035306) 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3035306 fadD2 910899 fadD2 Mycobacterium leprae TN acyl-CoA synthetase NP_302632.1 3033660 R 272631 CDS NP_302633.1 15828370 908412 3037538..3038206 1 NC_002677.1 hypothetical protein 3038206 908412 ML2549 Mycobacterium leprae TN hypothetical protein NP_302633.1 3037538 D 272631 CDS NP_302634.1 15828371 910897 3038228..3039145 1 NC_002677.1 hypothetical protein 3039145 910897 ML2550 Mycobacterium leprae TN hypothetical protein NP_302634.1 3038228 D 272631 CDS NP_302635.1 15828372 908410 3039192..3039740 1 NC_002677.1 aminoglycoside 2'-N-acetyltransferase 3039740 aac 908410 aac Mycobacterium leprae TN aminoglycoside 2'-N-acetyltransferase NP_302635.1 3039192 D 272631 CDS NP_302636.1 15828373 910893 3049294..3049590 1 NC_002677.1 hypothetical protein 3049590 910893 ML2557 Mycobacterium leprae TN hypothetical protein NP_302636.1 3049294 D 272631 CDS NP_302637.1 15828374 910892 complement(3053222..3053710) 1 NC_002677.1 oxidoreductase 3053710 910892 ML2561 Mycobacterium leprae TN oxidoreductase NP_302637.1 3053222 R 272631 CDS NP_302638.1 15828375 908401 3054587..3054877 1 NC_002677.1 hypothetical protein 3054877 908401 ML2562 Mycobacterium leprae TN hypothetical protein NP_302638.1 3054587 D 272631 CDS NP_302639.1 15828376 908400 3055229..3057064 1 NC_002677.1 acyl-CoA dehydrogenase 3057064 fadE5 908400 fadE5 Mycobacterium leprae TN acyl-CoA dehydrogenase NP_302639.1 3055229 D 272631 CDS NP_302640.1 15828377 910891 complement(3057486..3058859) 1 NC_002677.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3058859 fadA2 910891 fadA2 Mycobacterium leprae TN acetyl-CoA acetyltransferase NP_302640.1 3057486 R 272631 CDS NP_302641.1 15828378 908398 3058964..3060328 1 NC_002677.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3060328 fabG 908398 fabG Mycobacterium leprae TN 3-ketoacyl-ACP reductase NP_302641.1 3058964 D 272631 CDS NP_302642.1 15828379 908394 3061369..3062271 1 NC_002677.1 hypothetical protein 3062271 908394 ML2566 Mycobacterium leprae TN hypothetical protein NP_302642.1 3061369 D 272631 CDS NP_302643.1 15828380 910889 3062380..3062859 1 NC_002677.1 hypothetical protein 3062859 910889 ML2567 Mycobacterium leprae TN hypothetical protein NP_302643.1 3062380 D 272631 CDS NP_302644.1 15828381 908390 complement(3063262..3063888) 1 NC_002677.1 TetR family transcriptional regulator 3063888 908390 ML2568 Mycobacterium leprae TN TetR family transcriptional regulator NP_302644.1 3063262 R 272631 CDS NP_302645.1 15828382 908389 complement(3063958..3065121) 1 NC_002677.1 glycosyl hydrolase 3065121 908389 ML2569 Mycobacterium leprae TN glycosyl hydrolase NP_302645.1 3063958 R 272631 CDS NP_302646.1 15828383 910887 3065268..3065441 1 NC_002677.1 hypothetical protein 3065441 910887 ML2569A Mycobacterium leprae TN hypothetical protein NP_302646.1 3065268 D 272631 CDS NP_302647.1 15828384 908387 3065557..3069774 1 NC_002677.1 hypothetical protein 3069774 908387 ML2570 Mycobacterium leprae TN hypothetical protein NP_302647.1 3065557 D 272631 CDS NP_302648.1 15828385 910883 3072684..3074057 1 NC_002677.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 3074057 gabD1 910883 gabD1 Mycobacterium leprae TN succinate-semialdehyde dehydrogenase NP_302648.1 3072684 D 272631 CDS NP_302649.1 15828386 910886 complement(3080175..3081329) 1 NC_002677.1 acyltransferase 3081329 910886 ML2580 Mycobacterium leprae TN acyltransferase NP_302649.1 3080175 R 272631 CDS NP_302650.1 15828387 910878 3081538..3082821 1 NC_002677.1 hypothetical protein 3082821 910878 ML2581 Mycobacterium leprae TN hypothetical protein NP_302650.1 3081538 D 272631 CDS NP_302651.1 15828388 908377 3082923..3084725 1 NC_002677.1 hypothetical protein 3084725 908377 ML2582 Mycobacterium leprae TN hypothetical protein NP_302651.1 3082923 D 272631 CDS NP_302652.1 15828389 910885 complement(3085088..3086272) 1 NC_002677.1 glycosyl transferase family protein 3086272 910885 ML2583 Mycobacterium leprae TN glycosyl transferase family protein NP_302652.1 3085088 R 272631 CDS NP_302653.1 15828390 910879 3086325..3087134 1 NC_002677.1 hypothetical protein 3087134 910879 ML2584 Mycobacterium leprae TN hypothetical protein NP_302653.1 3086325 D 272631 CDS NP_302654.1 15828391 910875 3090766..3091569 1 NC_002677.1 hypothetical protein 3091569 yrbE1A 910875 yrbE1A Mycobacterium leprae TN hypothetical protein NP_302654.1 3090766 D 272631 CDS NP_302655.1 15828392 908358 3091573..3092442 1 NC_002677.1 hypothetical protein 3092442 yrbE1B 908358 yrbE1B Mycobacterium leprae TN hypothetical protein NP_302655.1 3091573 D 272631 CDS NP_302656.1 15828393 910890 3092446..3093771 1 NC_002677.1 cell invasion protein 3093771 mce1A 910890 mce1A Mycobacterium leprae TN cell invasion protein NP_302656.1 3092446 D 272631 CDS NP_302657.1 15828394 908355 3093768..3094808 1 NC_002677.1 hypothetical protein 3094808 mce1B 908355 mce1B Mycobacterium leprae TN hypothetical protein NP_302657.1 3093768 D 272631 CDS NP_302658.1 15828395 910873 3094805..3096364 1 NC_002677.1 hypothetical protein 3096364 mce1C 910873 mce1C Mycobacterium leprae TN hypothetical protein NP_302658.1 3094805 D 272631 CDS NP_302659.1 15828396 908354 3096361..3097956 1 NC_002677.1 hypothetical protein 3097956 mce1D 908354 mce1D Mycobacterium leprae TN hypothetical protein NP_302659.1 3096361 D 272631 CDS NP_302660.1 15828397 908351 3097953..3099131 1 NC_002677.1 lipoprotein 3099131 lprK 908351 lprK Mycobacterium leprae TN lipoprotein NP_302660.1 3097953 D 272631 CDS NP_302661.1 15828398 908342 3099125..3100675 1 NC_002677.1 hypothetical protein 3100675 mce1F 908342 mce1F Mycobacterium leprae TN hypothetical protein NP_302661.1 3099125 D 272631 CDS NP_302662.1 15828399 910876 3100808..3101356 1 NC_002677.1 hypothetical protein 3101356 910876 ML2595 Mycobacterium leprae TN hypothetical protein NP_302662.1 3100808 D 272631 CDS NP_302663.1 15828400 908340 3101353..3102330 1 NC_002677.1 hypothetical protein 3102330 908340 ML2596 Mycobacterium leprae TN hypothetical protein NP_302663.1 3101353 D 272631 CDS NP_302664.1 15828401 910872 3102327..3102881 1 NC_002677.1 hypothetical protein 3102881 910872 ML2597 Mycobacterium leprae TN hypothetical protein NP_302664.1 3102327 D 272631 CDS NP_302665.1 15828402 910874 3102971..3103525 1 NC_002677.1 hypothetical protein 3103525 910874 ML2598 Mycobacterium leprae TN hypothetical protein NP_302665.1 3102971 D 272631 CDS NP_302666.1 15828403 910869 complement(3104660..3106057) 1 NC_002677.1 hypothetical protein 3106057 910869 ML2600 Mycobacterium leprae TN hypothetical protein NP_302666.1 3104660 R 272631 CDS NP_302667.1 15828404 910871 3107546..3108385 1 NC_002677.1 hypothetical protein 3108385 910871 ML2603 Mycobacterium leprae TN hypothetical protein NP_302667.1 3107546 D 272631 CDS NP_302668.1 15828405 908331 3108446..3109195 1 NC_002677.1 hypothetical protein 3109195 908331 ML2604 Mycobacterium leprae TN hypothetical protein NP_302668.1 3108446 D 272631 CDS NP_302669.1 15828406 910867 3109192..3109698 1 NC_002677.1 hypothetical protein 3109698 910867 ML2605 Mycobacterium leprae TN hypothetical protein NP_302669.1 3109192 D 272631 CDS NP_302670.1 15828407 910866 complement(3113024..3114718) 1 NC_002677.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 3114718 ilvD 910866 ilvD Mycobacterium leprae TN dihydroxy-acid dehydratase NP_302670.1 3113024 R 272631 CDS NP_302671.1 15828408 908329 3114782..3115189 1 NC_002677.1 hypothetical protein 3115189 908329 ML2609 Mycobacterium leprae TN hypothetical protein NP_302671.1 3114782 D 272631 CDS NP_302672.1 15828409 908327 complement(3118765..3120768) 1 NC_002677.1 zinc metalloprotease 3120768 908327 ML2613 Mycobacterium leprae TN zinc metalloprotease NP_302672.1 3118765 R 272631 CDS NP_302673.1 15828410 910861 3120828..3121502 1 NC_002677.1 hypothetical protein 3121502 910861 ML2614 Mycobacterium leprae TN hypothetical protein NP_302673.1 3120828 D 272631 CDS NP_302674.1 15828411 908325 3121499..3122188 1 NC_002677.1 hypothetical protein 3122188 908325 ML2615 Mycobacterium leprae TN hypothetical protein NP_302674.1 3121499 D 272631 CDS NP_302675.1 15828412 910859 complement(3122267..3122779) 1 NC_002677.1 hypothetical protein 3122779 910859 ML2616 Mycobacterium leprae TN hypothetical protein NP_302675.1 3122267 R 272631 CDS NP_302676.1 15828413 910858 complement(3122776..3125817) 1 NC_002677.1 hypothetical protein 3125817 910858 ML2617 Mycobacterium leprae TN hypothetical protein NP_302676.1 3122776 R 272631 CDS NP_302677.1 15828414 910860 complement(3126434..3127492) 1 NC_002677.1 hypothetical protein 3127492 910860 ML2618 Mycobacterium leprae TN hypothetical protein NP_302677.1 3126434 R 272631 CDS NP_302678.1 15828415 910862 complement(3128833..3131700) 1 NC_002677.1 hypothetical protein 3131700 910862 ML2620 Mycobacterium leprae TN hypothetical protein NP_302678.1 3128833 R 272631 CDS NP_302679.1 15828416 910863 complement(3131780..3132367) 1 NC_002677.1 Some; hypothetical protein 3132367 910863 ML2621 Mycobacterium leprae TN hypothetical protein NP_302679.1 3131780 R 272631 CDS NP_302680.1 15828417 910881 complement(3132576..3133268) 1 NC_002677.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3133268 trmB 910881 trmB Mycobacterium leprae TN tRNA (guanine-N(7)-)-methyltransferase NP_302680.1 3132576 R 272631 CDS NP_302681.1 15828418 910856 3135274..3137103 1 NC_002677.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 3137103 pckA 910856 pckA Mycobacterium leprae TN phosphoenolpyruvate carboxykinase NP_302681.1 3135274 D 272631 CDS NP_302682.1 15828419 908319 3140261..3141280 1 NC_002677.1 hypothetical protein 3141280 908319 ML2627 Mycobacterium leprae TN hypothetical protein NP_302682.1 3140261 D 272631 CDS NP_302683.1 15828420 910855 complement(3144572..3145042) 1 NC_002677.1 hypothetical protein 3145042 910855 ML2629 Mycobacterium leprae TN hypothetical protein NP_302683.1 3144572 R 272631 CDS NP_302684.1 15828421 910851 complement(3145226..3145597) 1 NC_002677.1 hypothetical protein 3145597 910851 ML2630 Mycobacterium leprae TN hypothetical protein NP_302684.1 3145226 R 272631 CDS NP_302685.1 15828422 908317 complement(3147695..3149044) 1 NC_002677.1 oxidoreductase 3149044 908317 ML2631 Mycobacterium leprae TN oxidoreductase NP_302685.1 3147695 R 272631 CDS NP_302686.1 15828423 908314 complement(3151464..3152882) 1 NC_002677.1 [beta]; pyridine transhydrogenase subunit 3152882 pntB 908314 pntB Mycobacterium leprae TN pyridine transhydrogenase subunit NP_302686.1 3151464 R 272631 CDS NP_302687.1 15828424 910853 complement(3152879..3153217) 1 NC_002677.1 pyridine transhydrogenase subunit [alpha]2 3153217 pntAB 910853 pntAB Mycobacterium leprae TN pyridine transhydrogenase subunit [alpha]2 NP_302687.1 3152879 R 272631 CDS NP_302688.1 15828425 908312 complement(3153210..3154313) 1 NC_002677.1 pyridine transhydrogenase subunit [alpha]1 3154313 pntAA 908312 pntAA Mycobacterium leprae TN pyridine transhydrogenase subunit [alpha]1 NP_302688.1 3153210 R 272631 CDS NP_302689.1 15828426 908307 complement(3157362..3158867) 1 NC_002677.1 aldehyde dehydrogenase 3158867 908307 ML2639 Mycobacterium leprae TN aldehyde dehydrogenase NP_302689.1 3157362 R 272631 CDS NP_302690.1 15828427 910852 complement(3159055..3159987) 1 NC_002677.1 hypothetical protein 3159987 910852 ML2640 Mycobacterium leprae TN hypothetical protein NP_302690.1 3159055 R 272631 CDS NP_302691.1 15828428 908295 3166865..3167398 1 NC_002677.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 3167398 908295 ML2647 Mycobacterium leprae TN methionine sulfoxide reductase A NP_302691.1 3166865 D 272631 CDS NP_302692.1 15828429 910845 complement(3169324..3170139) 1 NC_002677.1 hypothetical protein 3170139 910845 ML2649 Mycobacterium leprae TN hypothetical protein NP_302692.1 3169324 R 272631 CDS NP_302693.1 15828430 908292 3173289..3173606 1 NC_002677.1 hypothetical protein 3173606 908292 ML2651 Mycobacterium leprae TN hypothetical protein NP_302693.1 3173289 D 272631 CDS NP_302694.1 15828431 910844 3176727..3177224 1 NC_002677.1 hypothetical protein 3177224 910844 ML2654 Mycobacterium leprae TN hypothetical protein NP_302694.1 3176727 D 272631 CDS NP_302695.1 15828432 910842 3177813..3178814 1 NC_002677.1 antigen 85A, mycolyltransferase 3178814 fbpC2 910842 fbpC2 Mycobacterium leprae TN antigen 85A, mycolyltransferase NP_302695.1 3177813 D 272631 CDS NP_302696.1 15828433 908288 complement(3182074..3183138) 1 NC_002677.1 serine protease 3183138 908288 ML2659 Mycobacterium leprae TN serine protease NP_302696.1 3182074 R 272631 CDS NP_302697.1 15828434 908287 complement(3185860..3187506) 1 NC_002677.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3187506 908287 ML2661 Mycobacterium leprae TN acyl-CoA synthetase NP_302697.1 3185860 R 272631 CDS NP_302698.1 15828435 908284 complement(3189375..3190307) 1 NC_002677.1 LysR family transcriptional regulator 3190307 oxyS 908284 oxyS Mycobacterium leprae TN LysR family transcriptional regulator NP_302698.1 3189375 R 272631 CDS NP_302699.1 15828436 908283 3190775..3191530 1 NC_002677.1 hypothetical protein 3191530 908283 ML2664 Mycobacterium leprae TN hypothetical protein NP_302699.1 3190775 D 272631 CDS NP_302700.1 15828437 908282 complement(3193706..3193960) 1 NC_002677.1 hypothetical protein 3193960 908282 ML2666 Mycobacterium leprae TN hypothetical protein NP_302700.1 3193706 R 272631 CDS NP_302701.1 15828438 910834 complement(3194549..3196405) 1 NC_002677.1 membrane transporter 3196405 910834 ML2667 Mycobacterium leprae TN membrane transporter NP_302701.1 3194549 R 272631 CDS NP_302702.1 15828439 910833 3197427..3197747 1 NC_002677.1 hypothetical protein 3197747 910833 ML2669 Mycobacterium leprae TN hypothetical protein NP_302702.1 3197427 D 272631 CDS NP_302703.1 15828440 908280 complement(3197961..3199961) 1 NC_002677.1 hypothetical protein 3199961 908280 ML2670 Mycobacterium leprae TN hypothetical protein NP_302703.1 3197961 R 272631 CDS NP_302704.1 15828441 910835 3204710..3209539 1 NC_002677.1 cation transport ATPase 3209539 910835 ML2671 Mycobacterium leprae TN cation transport ATPase NP_302704.1 3204710 D 272631 CDS NP_302705.1 15828442 910837 complement(3210647..3212887) 1 NC_002677.1 [NADP]; isocitrate dehydrogenase 3212887 icd2 910837 icd2 Mycobacterium leprae TN isocitrate dehydrogenase NP_302705.1 3210647 R 272631 CDS NP_302706.1 15828443 910830 3221695..3222405 1 NC_002677.1 TetR family transcriptional regulator 3222405 910830 ML2677 Mycobacterium leprae TN TetR family transcriptional regulator NP_302706.1 3221695 D 272631 CDS NP_302707.1 15828444 910831 3222402..3225404 1 NC_002677.1 hypothetical protein 3225404 910831 ML2678 Mycobacterium leprae TN hypothetical protein NP_302707.1 3222402 D 272631 CDS NP_302708.1 15828445 908273 3225401..3228082 1 NC_002677.1 hypothetical protein 3228082 908273 ML2679 Mycobacterium leprae TN hypothetical protein NP_302708.1 3225401 D 272631 CDS NP_302709.1 15828446 910801 complement(3230314..3232128) 1 NC_002677.1 replicative DNA helicase 3232128 dnaB 910801 dnaB Mycobacterium leprae TN replicative DNA helicase NP_302709.1 3230314 R 272631 CDS NP_302710.1 15828447 908270 complement(3232678..3233136) 1 NC_002677.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 3233136 rplI 908270 rplI Mycobacterium leprae TN 50S ribosomal protein L9 NP_302710.1 3232678 R 272631 CDS NP_302711.1 15828448 910829 complement(3233184..3233438) 1 NC_002677.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 3233438 rpsR 910829 rpsR Mycobacterium leprae TN 30S ribosomal protein S18 NP_302711.1 3233184 R 272631 CDS NP_302712.1 15828449 908269 complement(3233464..3233970) 1 NC_002677.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 3233970 ssb 908269 ssb Mycobacterium leprae TN single-stranded DNA-binding protein NP_302712.1 3233464 R 272631 CDS NP_302713.1 15828450 910827 complement(3234130..3234420) 1 NC_002677.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 3234420 rpsF 910827 rpsF Mycobacterium leprae TN 30S ribosomal protein S6 NP_302713.1 3234130 R 272631 CDS NP_302714.1 15828451 910826 complement(3234968..3236662) 1 NC_002677.1 hypothetical protein 3236662 910826 ML2687 Mycobacterium leprae TN hypothetical protein NP_302714.1 3234968 R 272631 CDS NP_302715.1 15828452 908266 complement(3236659..3238785) 1 NC_002677.1 penicillin-bonding protein 3238785 ponA 908266 ponA Mycobacterium leprae TN penicillin-bonding protein NP_302715.1 3236659 R 272631 CDS NP_302716.1 15828453 910824 complement(3239183..3239599) 1 NC_002677.1 hypothetical protein 3239599 910824 ML2689 Mycobacterium leprae TN hypothetical protein NP_302716.1 3239183 R 272631 CDS NP_302717.1 15828454 910823 3240798..3241340 1 NC_002677.1 hypothetical protein 3241340 910823 ML2691 Mycobacterium leprae TN hypothetical protein NP_302717.1 3240798 D 272631 CDS NP_302718.1 15828455 908264 3241421..3242530 1 NC_002677.1 hypothetical protein 3242530 908264 ML2692 Mycobacterium leprae TN hypothetical protein NP_302718.1 3241421 D 272631 CDS NP_302719.1 15828456 910822 3246782..3247513 1 NC_002677.1 MarR family transcriptional regulator 3247513 910822 ML2696 Mycobacterium leprae TN MarR family transcriptional regulator NP_302719.1 3246782 D 272631 CDS NP_302720.1 15828457 908259 complement(3248268..3249728) 1 NC_002677.1 hypothetical protein 3249728 pcnA 908259 pcnA Mycobacterium leprae TN hypothetical protein NP_302720.1 3248268 R 272631 CDS NP_302721.1 15828458 908257 3249915..3250670 1 NC_002677.1 hypothetical protein 3250670 908257 ML2698 Mycobacterium leprae TN hypothetical protein NP_302721.1 3249915 D 272631 CDS NP_302722.1 15828459 910820 3250667..3253060 1 NC_002677.1 hypothetical protein 3253060 910820 ML2699 Mycobacterium leprae TN hypothetical protein NP_302722.1 3250667 D 272631 CDS NP_302723.1 15828460 908256 3253057..3256677 1 NC_002677.1 hypothetical protein 3256677 908256 ML2700 Mycobacterium leprae TN hypothetical protein NP_302723.1 3253057 D 272631 CDS NP_302724.1 15828461 910819 3258250..3259626 1 NC_002677.1 thioredoxin; bifunctional thioredoxin reductase/thioredoxin 3259626 trxB 910819 trxB Mycobacterium leprae TN bifunctional thioredoxin reductase/thioredoxin NP_302724.1 3258250 D 272631 CDS NP_302725.1 15828462 908251 3259759..3260979 1 NC_002677.1 hydrolase 3260979 908251 ML2704 Mycobacterium leprae TN hydrolase NP_302725.1 3259759 D 272631 CDS NP_302726.1 15828463 908250 complement(3260976..3261755) 1 NC_002677.1 hypothetical protein 3261755 908250 ML2705 Mycobacterium leprae TN hypothetical protein NP_302726.1 3260976 R 272631 CDS NP_302727.1 15828464 910817 complement(3262108..3263115) 1 NC_002677.1 cell division protein 3263115 parB 910817 parB Mycobacterium leprae TN cell division protein NP_302727.1 3262108 R 272631 CDS NP_302728.1 15828465 910816 complement(3263112..3264167) 1 NC_002677.1 cell division protein 3264167 parA 910816 parA Mycobacterium leprae TN cell division protein NP_302728.1 3263112 R 272631 CDS NP_302729.1 15828466 910815 complement(3264164..3264910) 1 NC_002677.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 3264910 gidB 910815 gidB Mycobacterium leprae TN 16S rRNA methyltransferase GidB NP_302729.1 3264164 R 272631 CDS NP_302730.1 15828467 908249 complement(3264982..3265563) 1 NC_002677.1 hypothetical protein 3265563 908249 ML2709 Mycobacterium leprae TN hypothetical protein NP_302730.1 3264982 R 272631 CDS NP_302731.1 15828468 908248 complement(3265645..3266787) 1 NC_002677.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3266787 908248 ML2710 Mycobacterium leprae TN inner membrane protein translocase component YidC NP_302731.1 3265645 R 272631 CDS NP_302732.1 15828469 908246 complement(3267126..3267488) 1 NC_002677.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3267488 rnpA 908246 rnpA Mycobacterium leprae TN ribonuclease P NP_302732.1 3267126 R 272631 CDS NP_302733.1 15828470 910818 complement(3267510..3267653) 1 NC_002677.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3267653 rpmH 910818 rpmH Mycobacterium leprae TN 50S ribosomal protein L34 NP_302733.1 3267510 R 272631 CDS